keyword
https://read.qxmd.com/read/38474321/the-chd-protein-kismet-restricts-the-synaptic-localization-of-cell-adhesion-molecules-at-the-drosophila-neuromuscular-junction
#1
JOURNAL ARTICLE
Ireland R Smith, Emily L Hendricks, Nina K Latcheva, Daniel R Marenda, Faith L W Liebl
The appropriate expression and localization of cell surface cell adhesion molecules must be tightly regulated for optimal synaptic growth and function. How neuronal plasma membrane proteins, including cell adhesion molecules, cycle between early endosomes and the plasma membrane is poorly understood. Here we show that the Drosophila homolog of the chromatin remodeling enzymes CHD7 and CHD8, Kismet, represses the synaptic levels of several cell adhesion molecules. Neuroligins 1 and 3 and the integrins αPS2 and βPS are increased at kismet mutant synapses but Kismet only directly regulates transcription of neuroligin 2 ...
March 6, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38367785/exploring-the-therapeutic-potential-of-rab11-a-comprehensive-study-on-its-effectiveness-in-alleviating-rotenone-induced-molecular-pathogenesis-of-parkinson-s-disease-in-sh-sy5y-cells-and-its-synergistic-application-with-l-dopa-in-drosophila-models
#2
JOURNAL ARTICLE
Pooja Rai, Sada Nand Pandey, Jagat Kumar Roy
Dysfunctional mitophagy contributes to Parkinson's disease (PD) by affecting dopamine-producing neurons. Mutations in parkin and pink1 genes, linked to familial PD, impede the removal of damaged mitochondria. Previous studies suggested Rab11's involvement in mitophagy alongside Parkin and Pink1. Additionally, mitochondria-endoplasmic reticulum contact sites (MERCS) regulate cellular functions, including mitochondrial quality control and calcium regulation. Our study explored whether activating mitophagy triggers the unfolded protein response and ER stress pathway in SH-SY5Y human cells...
February 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38367779/osiris17-is-essential-for-stable-integrin-localization-and-function-during-insect-wing-epithelia-remodeling
#3
JOURNAL ARTICLE
Wei Dong, Chen-Yang Song, Meng-Qi Liu, Ying-Hao Gao, Zhang-Wu Zhao, Xu-Bo Zhang, Bernard Moussian, Jian-Zhen Zhang
The dynamic adhesion between cells and their extracellular matrix is essential for the development and function of organs. During insect wing development, two epithelial sheets contact each other at their basal sites through the interaction of βPS integrins with the extracellular matrix. We report that Osiris17 contributes to the maintenance of βPS integrins localization and function in developing wing of Drosophila and locust. In flies with reduced Osiris17 expression the epithelia sheets fail to maintain the integrity of basal cytoplasmic junctional bridges and basal adhesion...
February 15, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38331351/microcephaly-with-a-disproportionate-hippocampal-reduction-stem-cell-loss-and-neuronal-lipid-droplet-symptoms-in-trappc9-ko-mice
#4
JOURNAL ARTICLE
Sultan Aljuraysi, Mark Platt, Michela Pulix, Harish Poptani, Antonius Plagge
Mutations of the human TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9 (TRAPPC9) cause a neurodevelopmental disorder characterised by microcephaly and intellectual disability. Trappc9 constitutes a subunit specific to the intracellular membrane-associated TrappII complex. The TrappII complex interacts with Rab11 and Rab18, the latter being specifically associated with lipid droplets (LDs). Here we used non-invasive imaging to characterise Trappc9 knock-out (KO) mice as a model of the human hereditary disorder...
March 2024: Neurobiology of Disease
https://read.qxmd.com/read/38330198/altered-platelet-megakaryocyte-endocytosis-and-trafficking-of-albumin-and-fibrinogen-in-runx1-haplodeficiency
#5
JOURNAL ARTICLE
Fabiola Del Carpio-Cano, Guangfen Mao, Lawrence E Goldfinger, Jeremy G T Wurtzel, Liying Guan, Mohammad Afaque Alam, Kiwon Lee, Mortimer Poncz, A Koneti Rao
Platelet α-granules have numerous proteins, some synthesized by megakaryocytes (MK) and others not synthesized but incorporated by endocytosis, an incompletely understood process in platelets/MK. Germline RUNX1 haplodeficiency, referred to as familial platelet defect with predisposition to myeloid malignancies (FPDMM), is associated with thrombocytopenia, platelet dysfunction and granule deficiencies. In previous studies, we found that platelet albumin, fibrinogen and IgG were decreased in a FPDMM patient...
February 8, 2024: Blood Advances
https://read.qxmd.com/read/38325655/rab11-promotes-single-mauthner-cell-axon-regeneration-in-vivo-through-axon-guidance-molecule-ntng2b
#6
JOURNAL ARTICLE
Huaitong Yao, Yueru Shen, Zheng Song, Along Han, Xinghan Chen, Yawen Zhang, Bing Hu
Effective axon regeneration within the central nervous system (CNS) is pivotal for achieving functional recovery following spinal cord injury (SCI). Numerous extrinsic and intrinsic factors exert influences on the axon regeneration. While prior studies have demonstrated crucial involvement of specific members the Rab protein family in axon regeneration in the peripheral nervous system (PNS), the precise function of Rab11 in CNS axon regeneration in vivo remains elusive. Thus, our study aimed to elucidate the impact of Rab11 on the axon regeneration of Mauthner cells (M-cells) in zebrafish larvae...
February 5, 2024: Experimental Neurology
https://read.qxmd.com/read/38315726/endolysosomal-trafficking-controls-yolk-granule-biogenesis-in-vitellogenic-drosophila-oocytes
#7
JOURNAL ARTICLE
Yue Yu, Dongsheng Chen, Stephen M Farmer, Shiyu Xu, Beatriz Rios, Amanda Solbach, Xin Ye, Lili Ye, Sheng Zhang
Endocytosis and endolysosomal trafficking are essential for almost all aspects of physiological functions of eukaryotic cells. As our understanding on these membrane trafficking events are mostly from studies in yeast and cultured mammalian cells, one challenge is to systematically evaluate the findings from these cell-based studies in multicellular organisms under physiological settings. One potentially valuable in vivo system to address this challenge is the vitellogenic oocyte in Drosophila, which undergoes extensive endocytosis by Yolkless (Yl), a low-density lipoprotein receptor (LDLR), to uptake extracellular lipoproteins into oocytes and package them into a specialized lysosome, the yolk granule, for storage and usage during later development...
February 5, 2024: PLoS Genetics
https://read.qxmd.com/read/38294869/rab11-regulates-autophagy-at-dendritic-spines-in-an-mtor-and-nmda-dependent-manner
#8
JOURNAL ARTICLE
Aleksandra Janusz-Kaminska, Agnieszka Brzozowska, Aleksandra Tempes, Malgorzata Urbanska, Magdalena Blazejczyk, Jacek Miłek, Bozena Kuzniewska, Juan Zeng, Jan Wesławski, Katarzyna Kisielewska, Gary J Bassell, Jacek Jaworski
Synaptic plasticity is a process that shapes neuronal connections during neurodevelopment and learning and memory. Autophagy is a mechanism that allows the cell to degrade its unnecessary or dysfunctional components. Autophagosomes appear at dendritic spines in response to plasticity-inducing stimuli. Autophagy defects contribute to altered dendritic spine development, autistic-like behavior in mice, and neurological disease. While several studies have explored the involvement of autophagy in synaptic plasticity, the initial steps of the emergence of autophagosomes at the postsynapse remain unknown...
January 31, 2024: Molecular Biology of the Cell
https://read.qxmd.com/read/38291290/myosin-va-dependent-transport-of-nmda-receptors-in-hippocampal-neurons
#9
JOURNAL ARTICLE
Ru Gong, Linwei Qin, Linlin Chen, Ning Wang, Yifei Bao, Wei Lu
N-methyl-D-aspartate receptor (NMDAR) trafficking is a key process in the regulation of synaptic efficacy and brain function. However, the molecular mechanism underlying the surface transport of NMDARs is largely unknown. Here we identified myosin Va (MyoVa) as the specific motor protein that traffics NMDARs in hippocampal neurons. We found that MyoVa associates with NMDARs through its cargo binding domain. This association was increased during NMDAR surface transport. Knockdown of MyoVa suppressed NMDAR transport...
January 30, 2024: Neuroscience Bulletin
https://read.qxmd.com/read/38271673/targeting-src-sh3-domain-mediated-glycolysis-of-hepatic-stellate-cells-suppresses-transcriptome-myofibroblastic-activation-and-colorectal-liver-metastasis
#10
JOURNAL ARTICLE
Yuanguo Wang, Xianghu Wang, Bing Bai, Aurpita Shaha, Xipu He, Yingzi He, Zhenqing Ye, Vijay H Shah, Ningling Kang
BACKGROUND AND AIMS: TGFβ1 induces hepatic stellate cell (HSC) activation into metastasis-promoting cancer-associated fibroblasts (CAFs), but how the process is fueled remains incompletely understood. We studied metabolic reprograming induced by TGFβ1 in HSCs. APPROACHES AND RESULTS: Activation of cultured primary human HSCs was assessed by expression of myofibroblast markers. Glucose transporter 1 (Glut1) of murine HSC was disrupted by Cre /LoxP recombination...
January 24, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38211652/ikzf4-nono-rab11fip3-axis-promotes-immune-evasion-in-gastric-cancer-via-facilitating-pd-l1-endosome-recycling
#11
JOURNAL ARTICLE
Nuoqing Weng, Chuzhou Zhou, Yuhang Zhou, Yanping Zhong, Zhe Jia, Xionghui Rao, Huaiyu Qiu, Guangyan Zeng, Xinghan Jin, Jianbao Zhang, Zhehong Zhuang, Zhihao Liang, Yuan Deng, Qinghai Li, Shasha Yang, Huixing Luo, Huiyun Wang, Xiaobin Wu
As an immune checkpoint protein expressed by diverse cancer cells, programmed death ligand 1 (PD-L1) facilitates immune evasion by interacting with programmed cell death-1 (PD-1) on T cells. Despite the clinical benefits observed in various cancer types, strategies targeting PD-1/PD-L1 have demonstrated limited efficacy in gastric cancer (GC). Furthermore, the regulation of PD-L1, especially at post-translational modification levels, remains largely unknown. Therefore, it is crucial to elucidate the mechanisms governing PD-L1 expression to enhance anti-tumor immunity...
January 9, 2024: Cancer Letters
https://read.qxmd.com/read/38205348/biochemical-structure-and-function-of-trapp-complexes-in-the-cardiac-system
#12
JOURNAL ARTICLE
Peter Papaioannou, Michael J Wallace, Nipun Malhotra, Peter J Mohler, Mona El Refaey
Trafficking protein particle (TRAPP) is well reported to play a role in the trafficking of protein products within the Golgi and endoplasmic reticulum. Dysfunction in TRAPP has been associated with disorders in the nervous and cardiovascular systems, but the majority of literature focuses on TRAPP function in the nervous system solely. Here, we highlight the known pathways of TRAPP and hypothesize potential impacts of TRAPP dysfunction on the cardiovascular system, particularly the role of TRAPP as a guanine-nucleotide exchange factor for Rab1 and Rab11...
December 2023: JACC. Basic to Translational Science
https://read.qxmd.com/read/38191484/variants-in-the-wdr44-wd40-repeat-domain-cause-a-spectrum-of-ciliopathy-by-impairing-ciliogenesis-initiation
#13
JOURNAL ARTICLE
Andrea Accogli, Saurabh Shakya, Taewoo Yang, Christine Insinna, Soo Yeon Kim, David Bell, Kirill R Butov, Mariasavina Severino, Marcello Niceta, Marcello Scala, Hyun Sik Lee, Taekyeong Yoo, Jimmy Stauffer, Huijie Zhao, Chiara Fiorillo, Marina Pedemonte, Maria C Diana, Simona Baldassari, Viktoria Zakharova, Anna Shcherbina, Yulia Rodina, Christina Fagerberg, Laura Sønderberg Roos, Jolanta Wierzba, Artur Dobosz, Amanda Gerard, Lorraine Potocki, Jill A Rosenfeld, Seema R Lalani, Tiana M Scott, Daryl Scott, Mahshid S Azamian, Raymond Louie, Hannah W Moore, Neena L Champaigne, Grace Hollingsworth, Annalaura Torella, Vincenzo Nigro, Rafal Ploski, Vincenzo Salpietro, Federico Zara, Simone Pizzi, Giovanni Chillemi, Marzia Ognibene, Erin Cooney, Jenny Do, Anders Linnemann, Martin J Larsen, Suzanne Specht, Kylie J Walters, Hee-Jung Choi, Murim Choi, Marco Tartaglia, Phillippe Youkharibache, Jong-Hee Chae, Valeria Capra, Sung-Gyoo Park, Christopher J Westlake
WDR44 prevents ciliogenesis initiation by regulating RAB11-dependent vesicle trafficking. Here, we describe male patients with missense and nonsense variants within the WD40 repeats (WDR) of WDR44, an X-linked gene product, who display ciliopathy-related developmental phenotypes that we can model in zebrafish. The patient phenotypic spectrum includes developmental delay/intellectual disability, hypotonia, distinct craniofacial features and variable presence of brain, renal, cardiac and musculoskeletal abnormalities...
January 8, 2024: Nature Communications
https://read.qxmd.com/read/38187289/dasatinib-suppresses-collective-cell-migration-through-the-coordination-of-focal-adhesion-and-e-cadherin-in-colon-cancer-cells
#14
JOURNAL ARTICLE
Yi-Wen Lu, Xiang-Ling Hou, Hui-Min Koo, Wei-Ting Chao
Collective cell migration is an important process in cancer metastasis. Unlike single-cell migration, collective cell migration requires E -cadherin expression in the cell cohort. However, the mechanisms underlying cellular contact and focal adhesions remain unclear. In this study, Src was hypothesized to coordinate focal adhesion and Rab11-mediated E -cadherin distribution during collective cell migration. This study primarily used confocal microscopy to visualize the 3D structure of cell-cell contacts with associated molecules...
January 15, 2024: Heliyon
https://read.qxmd.com/read/38151077/basal-interaction-of-the-orphan-receptor-gpr101-with-arrestins-leads-to-constitutive-internalization
#15
JOURNAL ARTICLE
Dayana Abboud, Clauda Abboud, Asuka Inoue, Jean-Claude Twizere, Julien Hanson
GPR101 is an orphan G protein-coupled receptor that promotes growth hormone secretion in the pituitary. The microduplication of the GPR101 gene has been linked with the X-linked acrogigantism, or X-LAG, syndrome. This disease is characterized by excessive growth hormone secretion and abnormal rapid growth beginning early in life. Mechanistically, GPR101 induces growth hormone secretion through constitutive activation of multiple heterotrimeric G proteins. However, the full scope of GPR101 signaling remains largely elusive...
December 25, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/38102893/mechanisms-of-aquaporin-4-vesicular-trafficking-in-mammalian-cells
#16
JOURNAL ARTICLE
Andrea Markou, Philip Kitchen, Ahmed Aldabbagh, Mariaelena Repici, Mootaz M Salman, Roslyn M Bill, Zita Balklava
The aquaporin-4 (AQP4) water channel is abundantly expressed in the glial cells of the central nervous system and facilitates brain swelling following diverse insults, such as traumatic injury or stroke. Lack of specific and therapeutic AQP4 inhibitors highlights the need to explore alternative routes to control the water permeability of glial cell membranes. The cell surface abundance of AQP4 in mammalian cells fluctuates rapidly in response to changes in oxygen levels and tonicity, suggesting a role for vesicular trafficking in its translocation to and from the cell surface...
December 16, 2023: Journal of Neurochemistry
https://read.qxmd.com/read/38095212/mammalian-phagophores-with-finger-like-shapes-emerge-from-recycling-endosomes
#17
JOURNAL ARTICLE
Claudia Puri, David C Rubinsztein
Autophagosomes are double-membraned vesicles that engulf cytoplasmic contents, which are ultimately degraded after autophagosome-lysosome fusion. The prevailing view, largely inferred from EM-based studies, was that mammalian autophagosomes evolved from disc-shaped precursors that invaginated and then were closed at the single opening. Many site(s) of origin of these precursors have been proposed. Using superresolution structured illumination microscopy and electron microscopy, we find that mammalian autophagosomes derive from finger-like outgrowths from the recycling endosome...
December 14, 2023: Autophagy
https://read.qxmd.com/read/38086519/the-exocyst-subunit-sec15-is-critical-for-proper-synaptic-development-and-function-at-the-drosophila-nmj
#18
JOURNAL ARTICLE
Chris J Kang, Luis E Guzmán-Clavel, Katherine Lei, Martin Koo, Steven To, John P Roche
The exocyst protein complex is important for targeted vesicle fusion in a variety of cell types, however, its function in neurons is still not entirely known. We found that presynaptic knockdown (KD) of the exocyst component sec15 by transgenic RNAi expression caused a number of unexpected morphological and physiological defects in the synapse. These include the development of active zones (AZ) devoid of essential presynaptic proteins, an increase in the branching of the presynaptic arbor, the appearance of satellite boutons, and a decrease in the amplitude of stimulated postsynaptic currents as well as a decrease in the frequency of spontaneous synaptic vesicle release...
December 11, 2023: Molecular and Cellular Neurosciences
https://read.qxmd.com/read/38072191/rab11-suppresses-head-and-neck-carcinoma-by-regulating-egfr-and-epcam-exosome-secretion
#19
JOURNAL ARTICLE
Kunihiro Yoshida, Kaung Htike, Takanori Eguchi, Hotaka Kawai, Htoo Shwe Eain, Manh Tien Tran, Chiharu Sogawa, Koki Umemori, Tatsuo Ogawa, Hideka Kanemoto, Kisho Ono, Hitoshi Nagatsuka, Akira Sasaki, Soichiro Ibaragi, Kuniaki Okamoto
OBJECTIVES: Rab11(Rab11a and Rab11b) localizes primarily along recycling endosomes in cells and is involved in various intracellular trafficking processes, including membrane receptor recycling and secretion of exosomes or small extracellular vesicles (EVs). Although Rab11 is closely associated with the progression and metastasis of various cancer types, little is known about Rab11' role in head and neck squamous cell carcinoma (HNSCC). In this study, we investigated the roles of Rab11a and Rab11b in HNSCC...
December 8, 2023: Journal of Oral Biosciences
https://read.qxmd.com/read/38019180/coordination-of-rab-8-and-rab-11-during-unconventional-protein-secretion
#20
JOURNAL ARTICLE
Xinxin Li, Bowen Liu, Yue Wen, Jiabin Wang, Yusong R Guo, Anbing Shi, Long Lin
Multiple physiology-pertinent transmembrane proteins reach the cell surface via the Golgi-bypassing unconventional protein secretion (UcPS) pathway. By employing C. elegans-polarized intestine epithelia, we recently have revealed that the small GTPase RAB-8/Rab8 serves as an important player in the process. Nonetheless, its function and the relevant UcPS itinerary remain poorly understood. Here, we show that deregulated RAB-8 activity resulted in impaired apical UcPS, which increased sensitivity to infection and environmental stress...
February 5, 2024: Journal of Cell Biology
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