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https://www.readbyqxmd.com/read/29772958/arf6-and-rab11-as-intrinsic-regulators-of-axon-regeneration
#1
Bart Nieuwenhuis, Richard Eva
Adult central nervous system (CNS) axons do not regenerate after injury because of extrinsic inhibitory factors, and a low intrinsic capacity for axon growth. Developing CNS neurons have a better regenerative ability, but lose this with maturity. This mini-review summarises recent findings which suggest one reason for regenerative failure is the selective distribution of growth machinery away from axons as CNS neurons mature. These studies demonstrate roles for the small GTPases ARF6 and Rab11 as intrinsic regulators of polarised transport and axon regeneration...
May 17, 2018: Small GTPases
https://www.readbyqxmd.com/read/29769350/rab5-rab7-and-rab11-are-required-for-caveolae-dependent-endocytosis-of-classic-swine-fever-virus-in-porcine-alveolar-macrophages
#2
Yun-Na Zhang, Ya-Yun Liu, Fu-Chuan Xiao, Chun-Chun Liu, Xiao-Dong Liang, Jing Chen, Jing Zhou, Abdul Sattar Baloch, Lin Kan, Bin Zhou, Hua-Ji Qiu
The members of Flaviviridae utilize several endocytic pathways to enter a variety of host cells. Our previous work showed that classical swine fever virus (CSFV) enters porcine kidney (PK-15) cells through a clathrin-dependent pathway that requires Rab5 and Rab7. The entry mechanism for CSFV into other cell lines remains unclear, for instance, porcine alveolar macrophages (3D4/21 cells). More importantly, the trafficking of CSFV within endosomes controlled by Rab GTPases is unknown in 3D4/21 cells. In this study, entry and post-internalization of CSFV were analyzed using chemical inhibitors, RNA interference, and dominant negative (DN) mutants...
May 16, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29759989/novel-regulation-of-integrin-trafficking-by-rab11-fip5-in-aggressive-prostate-cancer
#3
Lipsa Das, Jaime M C Gard, Rytis Prekeris, Raymond B Nagle, Colm Morrissey, Beatrice S Knudsen, Cindy K Miranti, Anne E Cress
The laminin-binding integrins, α3β1 and α6β1, are needed for tumor metastasis and their surface expression is regulated by endocytic recycling. β1 integrins share the Rab11 recycling machinery but the trafficking of α3β1 and α6β1 are distinct by an unknown mechanism. Using a mouse PDX tumor model containing human metastatic prostate cancer, Rab11 family interacting protein 5 (Rab11-FIP5) was identified as a lead candidate for α6β1 trafficking. Rab11-FIP5 and its membrane binding domain were required for α6β1 recycling, without affecting the other laminin-binding integrin (i...
May 14, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29717108/the-aff-1-exoplasmic-fusogen-is-required-for-endocytic-scission-and-seamless-tube-elongation
#4
Fabien Soulavie, David H Hall, Meera V Sundaram
Many membranes must merge during cellular trafficking, but fusion and fission events initiating at exoplasmic (non-cytosolic) membrane surfaces are not well understood. Here we show that the C. elegans cell-cell fusogen anchor-cell fusion failure 1 (AFF-1) is required for membrane trafficking events during development of a seamless unicellular tube. EGF-Ras-ERK signaling upregulates AFF-1 expression in the excretory duct tube to promote tube auto-fusion and subsequent lumen elongation. AFF-1 is required for scission of basal endocytic compartments and for apically directed exocytosis to extend the apical membrane...
May 1, 2018: Nature Communications
https://www.readbyqxmd.com/read/29615992/epstein-barr-virus-acquires-its-final-envelope-on-intracellular-compartments-with-golgi-markers
#5
Asuka Nanbo, Takeshi Noda, Yusuke Ohba
Herpesvirus subfamilies typically acquire their final envelope in various cytoplasmic compartments such as the trans -Golgi network (TGN), and endosomes prior to their secretion into the extracellular space. However, the sites for the final envelopment of Epstein-Barr virus (EBV), a ubiquitous human gamma herpesvirus, are poorly understood. Here, we characterized the sites for the final envelopment of EBV in Burkitt's lymphoma cell lines induced into the lytic cycle by crosslinking cell surface IgG. Electron microscopy revealed the various stages of maturation and egress of progeny virions including mature EBV in irregular cytoplasmic vesicles...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29608571/endocytic-recycling-via-the-tgn-underlies-the-polarized-hyphal-mode-of-life
#6
Miguel Hernández-González, Ignacio Bravo-Plaza, Mario Pinar, Vivian de Los Ríos, Herbert N Arst, Miguel A Peñalva
Intracellular traffic in Aspergillus nidulans hyphae must cope with the challenges that the high rates of apical extension (1μm/min) and the long intracellular distances (>100 μm) impose. Understanding the ways in which the hyphal tip cell coordinates traffic to meet these challenges is of basic importance, but is also of considerable applied interest, as fungal invasiveness of animals and plants depends critically upon maintaining these high rates of growth. Rapid apical extension requires localization of cell-wall-modifying enzymes to hyphal tips...
April 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29582527/rab11-mediates-selective-recycling-and-endocytic-trafficking-in-trypanosoma-brucei
#7
Khan Umaer, Peter J Bush, James D Bangs
Trypanosoma brucei possesses a streamlined secretory system that guarantees efficient delivery to the cell surface of the critical GPI-anchored virulence factors, variable surface glycoprotein (VSG) and transferrin receptor (TfR). Both are thought to be constitutively endocytosed and returned to the flagellar pocket via TbRab11+ recycling endosomes. We use conditional knockdown with established reporters to investigate the role of TbRab11 in specific endomembrane trafficking pathways in bloodstream trypanosomes...
March 26, 2018: Traffic
https://www.readbyqxmd.com/read/29549340/transcytosis-of-trka-leads-to-diversification-of-dendritic-signaling-endosomes
#8
Kelly Barford, Austin Keeler, Lloyd McMahon, Kathryn McDaniel, Chan Choo Yap, Christopher D Deppmann, Bettina Winckler
The development of the peripheral nervous system relies on long-distance signaling from target organs back to the soma. In sympathetic neurons, this long-distance signaling is mediated by target derived Nerve Growth Factor (NGF) interacting with its axonal receptor, TrkA. This ligand receptor complex internalizes into what is commonly referred to as the signaling endosome which is transported retrogradely to the soma and dendrites to mediate survival signaling and synapse formation, respectively. The molecular identity of signaling endosomes in dendrites has not yet been determined...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29549047/the-breast-cancer-antigen-5t4-interacts-with-rab11-and-is-a-target-and-regulator-of-rab11-mediated-trafficking
#9
Janelle L Harris, Keyur Dave, Jeffrey Gorman, Kum Kum Khanna
BACKGROUND AND AIMS: 5T4 is a transmembrane glycoprotein with limited expression in normal adult tissues and expression in some solid tumours. It is unclear whether 5T4 is preferentially expressed by stem or differentiated cell types. Modes of 5T4 regulation are unknown despite its ongoing development as a cancer immunotherapy target. Our aims were to clarify the differentiation status of 5T4 expressing cells in breast cancer and to understand the mechanism underlying 5T4 membrane presentation...
June 2018: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29545069/ascorbic-acid-increases-svct2-localization-at-the-plasma-membrane-by-accelerating-its-trafficking-from-early-secretory-compartments-and-through-the-endocytic-recycling-pathway
#10
A Covarrubias-Pinto, A I Acuña, G Boncompain, E Papic, P V Burgos, F Perez, M A Castro
Ascorbic acid (Asc) is an antioxidant molecule essential for physiological functions. The concentration of extracellular Asc increases during synaptic transmission and renal reabsorption. These phenomena induce an increase of the Sodium-dependent-Vitamin-C-transporter 2 (SVCT2) at plasma membrane (PM) localization, as we previously demonstrated in neuronal and non-neuronal cells. Hence, the aim of this study was to evaluate intracellular SVCT2 trafficking kinetics in response to Asc. We observed two peaks of SVCT2 localization and function at the PM (at 5-10 min, "acute response", and 30-60 min, "post-acute response") when cells were incubated with Asc...
May 20, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29540997/overexpression-of-rab11-fip2-in-colorectal-cancer-cells-promotes-tumor-migration-and-angiogenesis-through-increasing-secretion-of-pai-1
#11
Wenjie Dong, Xinai Wu
Background: Rab11 family-interacting protein 2 (Rab11-FIP2) can interact with MYO5B and plays an important role in regulating plasma membrane recycling. However, little is known about the clinical significance of DUSP2 in colorectal cancer (CRC). Methods: In this study, we investigated Rab11-FIP2 expression by immunohistochemistry in 125 patients with colorectal cancer. Conditioned media containing all secreted factors was harvested. Chemokine secretion and expression were analyzed by Chemi-array...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29523681/half-life-extended-recombinant-coagulation-factor-ix-albumin-fusion-protein-is-recycled-via-the-fcrn-mediated-pathway
#12
Jenny Chia, Jade Louber, Isabelle Glauser, Shirley Taylor, Greg T Bass, Steve K Dower, Paul A Gleeson, Anne M Verhagen
The neonatal Fc receptor (FcRn) has a pivotal role in albumin and IgG homeostasis. Internalized IgG captured by FcRn under acidic endosomal conditions is recycled to the cell surface where exocytosis and a shift to neutral pH promote extracellular IgG release. Although a similar mechanism is proposed for FcRn-mediated albumin intracellular trafficking and recycling, this pathway is less well defined but is relevant to the development of therapeutics exploiting FcRn to extend the half-life of short-lived plasma proteins...
April 27, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29514977/the-hus-box-is-required-for-allosteric-regulation-of-the-sec7-arf-gef
#13
Steve L Halaby, J Christopher Fromme
The Golgi complex is the central membrane and protein-sorting station in eukaryotic cells. Activation of Arf (ADP-ribosylation factor) GTPases is essential for vesicle formation via recruitment of cargo adaptors and coat proteins necessary for Golgi trafficking. Arf activation is spatially and temporally regulated by distinct guanine nucleotide exchange factors (GEFs) at different Golgi compartments. The yeast Arf-GEF Sec7 is a conserved and essential activator of Arf1 at the trans -Golgi network. Sec7 contains a highly conserved regulatory region, the homology upstream of Sec7 (HUS) box, with an unknown mechanistic role...
May 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29514919/the-rab11-binding-protein-relch-kiaa1468-controls-intracellular-cholesterol-distribution
#14
Tomoaki Sobajima, Shin-Ichiro Yoshimura, Tomomi Maeda, Haruhiko Miyata, Eiji Miyoshi, Akihiro Harada
Cholesterol, which is endocytosed to the late endosome (LE)/lysosome, is delivered to other organelles through vesicular and nonvesicular transport mechanisms. In this study, we discuss a novel mechanism of cholesterol transport from recycling endosomes (REs) to the trans-Golgi network (TGN) through RELCH/KIAA1468, which is newly identified in this study as a Rab11-GTP- and OSBP-binding protein. After treating cells with 25-hydroxycholesterol to induce OSBP relocation from the cytoplasm to the TGN, REs accumulated around the TGN area, but this accumulation was diminished in RELCH- or OSBP-depleted cells...
May 7, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29514909/hiv-1-nef-antagonizes-serinc5-restriction-by-downregulation-of-serinc5-via-the-endosome-lysosome-system
#15
Jing Shi, Ran Xiong, Tao Zhou, Peiyi Su, Xihe Zhang, Xusheng Qiu, Hongmei Li, Sunan Li, Changqing Yu, Bin Wang, Chan Ding, Thomas E Smithgall, Yong-Hui Zheng
The primate lentiviral accessory protein Nef downregulates CD4 and major histocompatibility complex class I (MHC-I) from the cell surface via independent endosomal trafficking pathways to promote viral pathogenesis. In addition, Nef antagonizes a novel restriction factor, SERINC5 (Ser5), to increase viral infectivity. To explore the molecular mechanism of Ser5 antagonism by Nef, we determined how Nef affects Ser5 expression and intracellular trafficking in comparison to CD4 and MHC-I. We confirm that Nef excludes Ser5 from human immunodeficiency virus type 1 (HIV-1) virions by downregulating its cell surface expression via similar functional motifs required for CD4 downregulation...
June 1, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29514088/cep128-localizes-to-the-subdistal-appendages-of-the-mother-centriole-and-regulates-tgf-%C3%AE-bmp-signaling-at-the-primary-cilium
#16
Maren Mönnich, Louise Borgeskov, Loretta Breslin, Lis Jakobsen, Michaela Rogowski, Canan Doganli, Jacob M Schrøder, Johanne B Mogensen, Louise Blinkenkjær, Lea M Harder, Emma Lundberg, Stefan Geimer, Søren T Christensen, Jens S Andersen, Lars A Larsen, Lotte B Pedersen
The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material. During formation of primary cilia, the mother centriole transforms into a basal body that templates the ciliary axoneme. Ciliogenesis depends on mother centriole-specific distal appendages, whereas the role of subdistal appendages in ciliary function is unclear. Here, we identify CEP128 as a centriole subdistal appendage protein required for regulating ciliary signaling...
March 6, 2018: Cell Reports
https://www.readbyqxmd.com/read/29476049/vps3-and-vps8-control-integrin-trafficking-from-early-to-recycling-endosomes-and-regulate-integrin-dependent-functions
#17
C T H Jonker, R Galmes, T Veenendaal, C Ten Brink, R E N van der Welle, N Liv, J de Rooij, A A Peden, P van der Sluijs, C Margadant, J Klumperman
Recycling endosomes maintain plasma membrane homeostasis and are important for cell polarity, migration, and cytokinesis. Yet, the molecular machineries that drive endocytic recycling remain largely unclear. The CORVET complex is a multi-subunit tether required for fusion between early endosomes. Here we show that the CORVET-specific subunits Vps3 and Vps8 also regulate vesicular transport from early to recycling endosomes. Vps3 and Vps8 localise to Rab4-positive recycling vesicles and co-localise with the CHEVI complex on Rab11-positive recycling endosomes...
February 23, 2018: Nature Communications
https://www.readbyqxmd.com/read/29425893/the-mechanisms-behind-decreased-internalization-of-angiotensin-ii-type-1-receptor
#18
REVIEW
Jingwei Bian, Suli Zhang, Ming Yi, Mingming Yue, Huirong Liu
The internalization of angiotensin II type 1 receptor (AT1 R) plays an important role in maintaining cardiovascular homeostasis. Decreased receptor internalization is closely related to cardiovascular diseases induced by the abnormal activation of AT1 R, such as hypertension. However, the mechanism behind reduced AT1 R internalization is not fully understood. This review focuses on four parts of the receptor internalization process (the combination of agonists and receptors, receptor phosphorylation, endocytosis, and recycling) and summarizes the possible mechanisms by which AT1 R internalization is reduced based on these four parts of the process...
April 2018: Vascular Pharmacology
https://www.readbyqxmd.com/read/29358562/hypoxia-stimulates-invasion-and-migration-of-human-cervical-cancer-cell-lines-hela-siha-through-the-rab11-trafficking-of-integrin-%C3%AE-v%C3%AE-3-fak-pi3k-pathway-mediated-rac1-activation
#19
Hao Xu, Yuan Yuan, Wenqian Wu, Min Zhou, Qian Jiang, Linjun Niu, Jiayin Ji, Nianli Liu, Longzhen Zhang, Xia Wang
Hypoxia plays a key role in tumour cell survival, invasion, and metastasis. An increasing number of studies have attempted to characterize the tumour response to hypoxia and to identify predictive markers of disease. Here we show that hypoxia increases tumour cell invasion and migration by the modulation of Rab11, an important molecule for vesicular trafficking. In our study, we found that Rab11, together with the activation of Rac1, could stimulate invasion and migration of cervical cancer cell lines HeLa/SiHa in hypoxia...
September 2017: Journal of Biosciences
https://www.readbyqxmd.com/read/29341352/misregulation-of-membrane-trafficking-processes-in-human-nonalcoholic-steatohepatitis
#20
Anika L Dzierlenga, Nathan J Cherrington
Nonalcoholic steatohepatitis (NASH) remodels the expression and function of genes and proteins that are critical for drug disposition. This study sought to determine whether disruption of membrane protein trafficking pathways in human NASH contributes to altered localization of multidrug resistance-associated protein 2 (MRP2). A comprehensive immunoblot analysis assessed the phosphorylation, membrane translocation, and expression of transporter membrane insertion regulators, including several protein kinases (PK), radixin, MARCKS, and Rab11...
January 17, 2018: Journal of Biochemical and Molecular Toxicology
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