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Candidemia

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https://www.readbyqxmd.com/read/27884707/polyclonal-anti-candida-antibody-improves-phagocytosis-and-overall-outcome-in-zebrafish-model-of-disseminated-candidiasis
#1
Audrey C Bergeron, Sarah E Barker, Kimberly M Brothers, Brinda C Prasad, Robert T Wheeler
Fungal infections are a major cause of animal and plant morbidity and mortality worldwide. Effective biological therapeutics could complement current antifungal drugs, but understanding of their in vivo mechanisms has been hampered by technical barriers to intravital imaging of host-pathogen interactions. Here we characterize the fungal infection of zebrafish as a model to understand the mechanism-of-action for biological antifungal therapeutics through intravital imaging of these transparent animals. We find that non-specific human IgG enhances phagocytosis by zebrafish phagocytes in vivo...
November 21, 2016: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/27884125/epidemiology-of-and-risk-factors-for-neonatal-candidemia-at-a-tertiary-care-hospital-in-western-china
#2
Jichang Chen, Yongjiang Jiang, Ba Wei, Yanling Ding, Shaolin Xu, Peixu Qin, Jinjian Fu
BACKGROUND: The prevalence and clinical characteristics of neonatal candidemia are poorly understood in western China. The aim of our study was to evaluate the epidemiological features of neonatal candidemia in the Liuzhou Maternity and Child Healthcare Hospital. METHODS: A retrospective case-control study was conducted between January 2012 and November 2015. Electronic databases were reviewed and data on Candida species were isolated from blood cultures and candidemia incidence, risk factors, and mortality were extracted...
November 24, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27872072/pharmacokinetics-of-anidulafungin-in-critically-ill-patients-in-the-intensive-care-unit-with-suspected-or-proven-invasive-fungal-infections
#3
R J M Brüggemann, V Middel-Baars, D W de Lange, A Colbers, A R J Girbes, P Pickkers, E L Swart
Echinocandins, such as anidulafungin are first line treatment for candidemia or invasive candidiasis in critically ill patients. There is conflicting data on the pharmacokinetic properties of anidulafungin in ICU patients. Adult ICU patients (from 3 hospitals) receiving anidulafungin for suspected or proven fungal infections were included. Patient were considered evaluable when a pharmacokinetic curve on day 3 could be completed. 23 out of 36 patients (7 female, 16 male) were evaluable. Median (range) age and bodyweight were 66 (28-88) yr and 76 (50-115) kg...
November 21, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27862414/epidemiology-and-cost-implications-of-candidemia-a-6-year-analysis-from-a-developing-country
#4
Aysegul Ulu Kilic, Emine Alp, Fatma Cevahir, Zeynep Ture, Nuran Yozgat
Surveillance of candidemia is essential to monitor trends in species distribution and change in the incidence and antifungal resistance. In this study, we aimed to investigate prevalence, resistance rates, antifungal utilization and costs. A 6-year retrospective analysis of the data belonging to patients with candidemia hospitalized between 2010 and 2016 was performed. The annual usage of fluconazole and caspofungin and the usage of these antifungals in different units were described in defined daily doses (DDD) per 1000 patient days...
November 9, 2016: Mycoses
https://www.readbyqxmd.com/read/27859978/breakthrough-fungemia-due-to-candida-fermentati-with-fks1p-mutation-under-micafungin-treatment-in-a-cord-blood-transplant-recipient
#5
Takaaki Konuma, Shunsuke Takahashi, Tomohiko Kiyuna, Yuta Miharu, Masato Suzuki, Hiroko Shibata, Seiko Kato, Satoshi Takahashi, Arinobu Tojo
The prophylactic use of antifungal drugs in allogeneic hematopoietic cell transplant recipients has revealed that the rate of non-albicans candidemia has increased. We herein report the case of a patient with adult T-cell leukemia who developed candidemia due to Candida fermentati during micafungin treatment after cord blood transplantation. The isolate was identified on day 47 by sequencing of the internal transcribed spacer region of the ribosomal RNA gene. The sequencing of the hot spot region of fks1p of isolate revealed naturally occurring amino acid substitutions, which conferred reduced echinocandin susceptibility...
November 15, 2016: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/27850329/690-discontinuation-of-micafungin-therapy-utilizing-a-validated-clinical-predication-rule-for-candidemia
#6
Gabrielle Gibson, Mollie Gowan, Paul Juang, Scott Micek, Marin Kollef
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850307/668-impact-of-candida-colonization-to-predict-candidemia-in-intensive-care-unit-patients
#7
Daniel Kett, Roland Schein, Cynthia Cely, Luis Rosario, Sameer Bajaj, Rajan Garg, Andrew Quartin
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27837513/t2-magnetic-resonance-for-fungal-diagnosis
#8
Fainareti N Zervou, Ioannis M Zacharioudakis, Jaclynn Kurpewski, Eleftherios Mylonakis
Rapid diagnostic methods for fungal infections are long awaited and are expected to improve outcomes through early initiation of targeted antifungal therapy. T2Candida panel is a novel qualitative diagnostic platform that was recently approved by the US Food and Drug Administration (FDA) for diagnosis of candidemia with a mean time to species identification of less than 5 h. T2Candida panel is performed on the fully automated T2Dx instrument in whole blood K2EDTA specimens and is able to detect 5 Candida spp...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27837497/the-changing-epidemiology-of-invasive-fungal-infections
#9
David A Enoch, Huina Yang, Sani H Aliyu, Christianne Micallef
Invasive fungal infections (IFI) are an emerging problem worldwide with invasive candidiasis and candidemia responsible for the majority of cases. This is predominantly driven by the widespread adoption of aggressive immunosuppressive therapy among certain patient populations (e.g., chemotherapy, transplants) and the increasing use of invasive devices such as central venous catheters (CVCs). The use of new immune modifying drugs has also opened up an entirely new spectrum of patients at risk of IFIs. While the epidemiology of candida infections has changed in the last decade, with a gradual shift from C...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27832392/epidemiology-and-mortality-of-candidemia-both-related-and-unrelated-to-the-central-venous-catheter-a-retrospective-cohort-study
#10
S Arias, O Denis, I Montesinos, S Cherifi, V Y Miendje Deyi, F Zech
Our objective was to compare mortality, epidemiology, and morbidity in hospitalized patients with candidemia which was both related and unrelated to the central venous catheter (CVC). This was a monocentric, retrospective cohort study of candidemia. The sample consisted of 103 patients with laboratory-confirmed nosocomial candidemia hospitalized between 2006 and 2013 in a tertiary care public hospital. We included 65 (63.1 %) patients (24 in the CVC-positive group, 41 in the CVC-negative group). Demographic data and risk factors were recorded using a structured case report form...
November 10, 2016: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/27812015/understanding-the-antifungal-mechanism-of-ag-zno-core-shell-nanocomposites-against-candida-krusei
#11
Bhaskar Das, Md Imran Khan, R Jayabalan, Susanta K Behera, Soon-Il Yun, Suraj K Tripathy, Amrita Mishra
In the present paper, facile synthesis of Ag@ZnO core-shell nanocomposites is reported where zinc oxide is coated on biogenic silver nanoparticles synthesized using Andrographis paniculata and Aloe vera leaf extract. Structural features of as synthesized nanocomposites are characterized by UV-visible spectroscopy, XRD, and FTIR. Morphology of the above core-shell nanocomposites is investigated by electron microscopy. As synthesized nanocomposite material has shown antimicrobial activity against Candida krusei, which is an opportunistic pathogen known to cause candidemia...
November 4, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27802412/cytographic-changes-on-bc-6800-haematological-analyzer-related-to-the-presence-of-candida-albicans-in-peripheral-blood-a-new-tool-to-suspect-candidemia
#12
Antonio La Gioia, Alessandra Devito, Fabiana Fiorini, Maria Bombara, Patrizia Isola, Barbara Spinale, Lucia Francioni, Domenico Salamone, Paola Marelli, Sabrina Buoro, Marcello Fiorini
BACKGROUND: We studied the quantitative and cytographic changes that the presence of Candida albicans (C. albicans) in peripheral blood (PB) samples causes on the Mindray BC-6800 Haematological Analyzer. METHODS: A simulated in vitro candidemia was obtained by adding a different amount of C. albicans to discarded remnants of PB samples. Quantitative data and cytographic features were evaluated immediately as well as after 120 and 240 min of the yeast addition...
October 31, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27799221/frequency-of-the-paradoxical-effect-measured-using-eucast-with-micafungin-anidulafungin-and-caspofungin-against-candida-spp-isolates-causing-candidemia
#13
Laura Judith Marcos-Zambrano, Pilar Escribano, Carlos Sánchez-Carrillo, Emilio Bouza, Jesús Guinea
We report data on the frequency of the paradoxical effect of echinocandins against Candida spp. (n= 602 incident isolates) using the EUCAST EDef 7.2 procedure. The paradoxical effect for one or more echinocandins was observed in 16% of the isolates. However, differences between species were found, and the paradoxical effect was more common in Candida tropicalis (P<0.001). Caspofungin was the drug in which the paradoxical effect was most common, followed by anidulafungin and micafungin (P<0.001).
October 31, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27798663/epidemiology-of-blood-stream-infection-due-to-candida-species-in-a-tertiary-care-hospital-in-japan-over-12-years-importance-of-peripheral-line-associated-candidemia
#14
Masahiro Ishikane, Kayoko Hayakawa, Satoshi Kutsuna, Nozomi Takeshita, Norio Ohmagari
BACKGROUND: Candidemia is an important cause of mortality in healthcare settings. Peripheral lines are a source of candidemia, yet few studies have reported on the clinico-epidemiological features of candidemia due to peripheral-line associated blood stream infection (PLABSI). METHODS: We conducted a single-centre retrospective cohort study of all patients with candidemia between 2002 and 2013. PLABSI was defined as the presence of at least one of the following: the presence of phlebitis or the resolution of clinical symptoms after peripheral-line withdrawal, with careful exclusion of an alternative explanation for bacteraemia...
2016: PloS One
https://www.readbyqxmd.com/read/27795344/rapid-detection-and-identification-of-candidemia-by-direct-blood-culturing-on-solid-medium-using-lysis-centrifugation-method-combined-with-maldi-tof-ms
#15
Evgeny A Idelevich, Barbara Grünastel, Karsten Becker
Candida sepsis is a life-threatening condition with increasing prevalence. In this study, direct blood culturing on solid medium using lysis-centrifugation procedure allowed successful Candida species identification by matrix-assisted laser desorption ionization time-of-flight mass spectrometry on average 3.8 hours (Sabouraud agar) or 7.4 hours (chocolate agar) prior to the positivity signal for control samples in BACTEC Mycosis-IC/F or BACTEC Plus Aerobic/F bottles, respectively. Direct culturing on solid medium accelerates candidemia diagnostics compared to automated broth-based systems...
October 19, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27753765/risk-adjustment-for-congenital-heart-surgery-score-as-a-risk-factor-for-candidemia-in-children-undergoing-congenital-heart-defect-surgery
#16
Fabio de Araujo Motta, Libera Maria Dalla-Costa, Marisol Dominguez Muro, Andrea Lenzi, Gledson Luiz Picharski, Marion Burger
BACKGROUND: Candida species are the primary cause of invasive fungal infection in hospitalized children. There are few data on risk factors for postoperative candidemia in pediatric patients with congenital heart defects. This study aimed to identify risk factors for candidemia in patients with congenital heart defects who underwent cardiac surgery. METHODS: This was a case-control study conducted in patients admitted to a pediatric cardiology intensive care unit from January 2006 to December 2013...
November 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27753001/cand-lo-2014-15-study-changing-epidemiology-of-candidemia-in-lombardy-italy
#17
Anna Prigitano, Caterina Cavanna, Marco Passera, Cristina Ossi, Eugenio Sala, Gianluigi Lombardi, Anna Grancini, Concetta De Luca, Simone Bramati, Marina Gelmi, Milvana Tejada, Romualdo Grande, Claudio Farina, Fabiola Lallitto, Anna Maria Tortorano
PURPOSE: The aim of this study was to monitor recent changes in the epidemiology of candidemia and in the antifungal susceptibility profiles of Candida isolates in one Italian region (Lombardy) in 2014-2015 in comparison with two other studies performed in the same area in 1997-1999 and in 2009. METHODS: A laboratory-based surveillance was conducted in 11 microbiology laboratories. Identification of Candida isolates from 868 episodes and antifungal susceptibility testing (YeastOne) was performed locally...
October 17, 2016: Infection
https://www.readbyqxmd.com/read/27750452/epidemiology-of-candidemia-and-antifungal-susceptibility-in-invasive-candida-species-in-the-asia-pacific-region
#18
He Wang, Ying-Chun Xu, Po-Ren Hsueh
In the Asia-Pacific region, Candida albicans is the predominant Candida species causing invasive candidiasis/candidemia in Australia, Japan, Korea, Hong Kong, Malaysia, Singapore and Thailand whereas C. tropicalis is the most frequently encountered Candida species in Pakistan and India. Invasive isolates of C. albicans, C. parapsilosis complex and C. tropicalis remain highly susceptible to fluconazole (>90% susceptible). Fluconazole resistance (6.8-15%), isolates with the non-wild-type phenotype for itraconazole susceptibility (3...
October 2016: Future Microbiology
https://www.readbyqxmd.com/read/27736956/a-dedicated-fungal-culture-medium-is-useful-in-the-diagnosis-of-fungemia-a-retrospective-cross-sectional-study
#19
Shuwei Zheng, Tong Yong Ng, Huihua Li, Ai Ling Tan, Thuan Tong Tan, Ban Hock Tan
BACKGROUND: Mortality for candidemia ranges from 15% to 35%. Current guidelines recommend inoculating blood into three aerobic and three anaerobic blood culture bottles when candidemia is suspected, without mention of a fungal blood culture bottle. OBJECTIVE: To determine the value of the BACTEC Myco/F Lytic blood culture media in the diagnosis of fungemia. METHODS: A two-year retrospective cross-sectional study was performed for patients who had fungemia with submitted BACTEC Plus Aerobic/F (Aer), BACTEC Plus Anaerobic/F (Anaer) or Myco/F Lytic (Myco) blood culture bottles...
2016: PloS One
https://www.readbyqxmd.com/read/27733324/clinical-significance-of-isolated-biliary-candidiasis-in-patients-with-unresectable-cholangiocarcinoma
#20
In-Ho Kim, Jae-Ki Choi, Dong-Gun Lee, In Seok Lee, Tae Ho Hong, Young Kyoung You, Ho Jong Chun, Myung Ah Lee
BACKGROUND: The frequency of isolated biliary candidiasis is increasing in cancer patients. The clinical significance of isolated biliary candidiasis remains unclear. We analyzed the risk factors of biliary candidiasis and outcomes of the patients with unresectable cholangiocarcinoma after percutaneous transhepatic biliary drainage (PTBD). METHODS: Among 430 patients who underwent PTBD between January 2012 and March 2015, 121 patients had unresectable cholangiocarcinoma...
October 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
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