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https://www.readbyqxmd.com/read/28919715/in-vitro-inhibitory-activities-of-magnolol-against-candida-spp
#1
Peiru Zhou, Jingya Fu, Hong Hua, Xiaosong Liu
Candida spp. cause various infections involving the skin, mucosa, deep tissues, and even life-threatening candidemia. They are regarded as an important pathogen of nosocomial bloodstream infection, with a high mortality rate. As a result of prolonged exposure to azoles, the therapeutic failure associated with azoles resistance has become a serious challenge in clinical situations. Therefore, novel, alternative antifungals are required urgently. In the present study, the CLSI M-27A broth microdilution method and the 2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) reduction assay were used to evaluate the antifungal effects of magnolol against various standard Candida strains in planktonic mode and biofilm formation, respectively...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28903607/candida-endocarditis-systematic-literature-review-from-1997-to-2014-and-analysis-of-29-cases-from-the-italian-study-of-endocarditis
#2
Simone Giuliano, Maurizio Guastalegname, Alessandro Russo, Marco Falcone, Veronica Ravasio, Marco Rizzi, Matteo Bassetti, Pierluigi Viale, Maria Bruna Pasticci, Emanuele Durante-Mangoni, Mario Venditti
Candida Endocarditis (CE) is a deadly disease. It is of paramount importance to assess risk factors for acquisition of both Candida native (NVE) and prosthetic (PVE) valve endocarditis and relate clinical features and treatment strategies with the outcome of the disease. Areas covered: We searched the literature using the Pubmed database. Cases of CE from the Italian Study on Endocarditis (SEI) were also included. Overall, 140 cases of CE were analyzed. Patients with a history of abdominal surgery and antibiotic exposure had higher probability of developing NVE than PVE...
September 14, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28886952/clinical-manifestations-of-candidemia-caused-by-uncommon-candida-species-and-antifungal-susceptibility-of-the-isolates-in-a-regional-hospital-in-taiwan-2007-2014
#3
Wei-Lun Liu, Chih-Cheng Lai, Ming-Chi Li, Chi-Jung Wu, Wen-Chien Ko, Yi-Li Hung, Hung-Jen Tang, Po-Ren Hsueh
OBJECTIVE: This retrospective study investigated clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan. METHODS: The uncommon Candida species was initially defined as Candida species other than C. albicans, C. tropicalis, C. glabrata complex, C. parapsilosis complex and C. krusei. All uncommon Candida isolates were identified and confirmed by molecular methods. In vitro susceptibility testing of the uncommon Candida species to nine antifungal agents was conducted using the broth microdilution method with the Sensititre YeastOne (SYO) system (Trek Diagnostic Systems, Ltd...
August 26, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28884129/candidemia-in-the-neonatal-intensive-care-unit-a-retrospective-observational-survey-and-analysis-of-literature-data
#4
Giuseppina Caggiano, Grazia Lovero, Osvalda De Giglio, Giovanna Barbuti, Osvaldo Montagna, Nicola Laforgia, Maria Teresa Montagna
We evaluated the epidemiology of Candida bloodstream infections in the neonatal intensive care unit (NICU) of an Italian university hospital during a 9-year period as a means of quantifying the burden of infection and identifying emerging trends. Clinical data were searched for in the microbiological laboratory database. For comparative purposes, we performed a review of NICU candidemia. Forty-one candidemia cases were reviewed (overall incidence, 3.0 per 100 admissions). Candida parapsilosis sensu stricto (58...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28882010/invasive-candidiasis-in-the-neutropenic-patient
#5
REVIEW
J Fortún, F Gioia
There are major differences in the epidemiology and prognosis of invasive candidiasis and candidemia in the neutropenic patient; however, a recent study performed in Spanish hospitals (Candipop) confirmed that mortality at 1 month is 30%, which is similar to that observed in the general population. Although Candida albicans is the most frequently isolated species, C. tropicalis, C. glabrata, and C. krusei are more prevalent than in non-neutropenic patients. The benefit of neutrophil transfusion is unclear, and catheter withdrawal must be tailored and based on confirmation of the diagnosis...
September 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28877374/role-of-oral-nystatin-prophylaxis-in-cardiac-surgery-with-prolongedextracorporeal-circulation
#6
Alessandro Russo, Giovanni Carriero, Alessio Farcomeni, Giancarlo Ceccarelli, Luigi Tritapepe, Mario Venditti
Duration >120 minutes of extracorporeal circulation (ECC) during cardiopulmonary bypass procedure was associated to an increased risk of candidemia in the intensive care unit (ICU). To evaluate oral nystatin prophylaxis in cardiac surgery considering its exclusive effect on Candida, in the absence of systemic effects and selection of resistant strains to polyene. We conducted an observational study in the postcardiac surgery ICU of Policlinico "Umberto I" of Rome. From January 2014, all patients with a prolonged ECC >120 minutes were systematically treated with oral nystatin (Prophylaxis group)...
September 6, 2017: Mycoses
https://www.readbyqxmd.com/read/28872714/microbial-epidemiology-of-candidemia-in-neonatal-and-pediatric-intensive-care-units-at-children-s-medical-center-tehran
#7
Arezu Charsizadeh, Hossein Mirhendi, Bahram Nikmanesh, Hamid Eshaghi, Koichi Makimura
Invasive candidiasis is a major cause of morbidity and mortality in children. However, limited data is available on the epidemiology of this infection in pediatric settings in Iran. The aim of the present study was to determine the prevalence, microbial epidemiology, risk factors, and clinical outcomes associated with candidemia in intensive care units at Children's Medical Center, Tehran, Iran. All blood and other normally sterile specimen cultures positive for Candida species, were included. Isolates were identified by morphological and molecular methods...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28847765/acute-disseminated-candidiasis-with-skin-lesions-a-systematic-review
#8
REVIEW
Mariana Guarana, Marcio Nucci
BACKGROUND: Neutropenic patients developing acute disseminated candidiasis may present with skin lesions. AIMS: To evaluate the epidemiology of acute disseminated candidiasis with skin lesions in neutropenic patients, taking into consideration changes caused by different prophylactic strategies. SOURCES: A systematic review of English articles using PubMed (1963-2016) was performed. We asked the following questions: (1) What Candida species are more frequently involved in this syndrome? (2) Has antifungal prophylaxis changed the species causing skin lesions? (3) What are the typical patterns of skin lesions? (4) What is the frequency of skin lesions in neutropenic patients with candidemia or acute disseminated candidiasis? (5) Has antifungal prophylaxis decreased the incidence of acute disseminated candidiasis with skin lesions? CONTENT: Among 183 studies, 33 were selected, reporting 100 cases of acute disseminated candidiasis with skin lesions in neutropenic patients...
August 25, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28843335/the-identification-of-meyerozyma-guilliermondii-from-blood-cultures-and-surveillance-samples-in-a-university-hospital-in-northeast-turkey-a-ten-year-survey
#9
N Cebeci Güler, I Tosun, F Aydin
Meyerozyma (Pichia) guilliermondii exists in human skin and mucosal surface microflora. It can cause severe fungal infections like candidemia, which is an opportunistic pathogen. One hundred and forty-one M. guilliermondii isolates, consisting of 122 blood culture isolates, belonging to 126 patients; 13 total parenteral nutrition solution isolates; and two rectal swab isolates were identified according to carbohydrate assimilation reactions in a university hospital in Turkey between January 2006 and December 2015...
August 23, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28836465/epidemiology-and-antifungal-susceptibilities-of-yeast-isolates-causing-invasive-infections-across-urban-beijing-china
#10
Li-Na Guo, Meng Xiao, Bin Cao, Fen Qu, Yu-Liang Zhan, Yun-Jian Hu, Xin-Ru Wang, Guo-Wei Liang, Hai-Tong Gu, Jun Qi, Hui Yuan, Rong Min, Fei-Yan Wang, Lin-Juan Liu, Hai-Bin Wang, Wei Jiang, Xue-Guang Duan, Wen-Jian Xu, Yan-Hua Yu, Jian-Rong Su, Jian-Zhong Zhang, Jin-Qing Nong, Shu-Mei Liu, Jun Li, Jun-Ting Liu, Zhi-Gang Yue, Duo Yang, Jie Guo, Rui Zhao, Ya-Nan Zhang, Xi-Ming Yang, Xiao-Qing Liu, Po-Ren Hsueh, Ying-Chun Xu
AIM: To investigate the species distribution and antifungal susceptibility profiles of yeast isolates causing invasive infections across Beijing. MATERIALS & METHODS: A total of 1201 yeast isolates recovered from blood and other sterile body fluids were correctly identified by matrix-assisted laser desorption/ionization TOF MS supplemented by DNA sequencing. Antifungal susceptibility testing was performed according to the Clinical and Laboratory Standards Institute broth microdilution method...
August 24, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28834694/ruxolitinib-for-secondary-hemophagocytic-lymphohistiocytosis-first-case-report
#11
Jonathan H Sin, Mark L Zangardi
Hemophagocytic lymphohistiocytosis (HLH) is an immune-mediated disorder resulting in hyper-activation of inflammatory cytokines. If left untreated, the uncontrolled inflammatory response can lead to significant tissue injury and potentially life-threatening multi-organ dysfunction. Conventional immunosuppressive agents are available for the management of HLH, including dexamethasone, cyclosporine, and etoposide; however, patients may not respond to these therapies. Clinicians may turn toward alternative pharmacologic agents that likely have less clinical evidence...
August 16, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28826987/in-vitro-potency-and-fungicidal-activity-of-cd101-a-novel-echinocandin-against-recent-clinical-isolates-of-candida-spp
#12
Danielle Hall, Robert Bonifas, Lauretta Stapert, Mary Thwaites, Dean L Shinabarger, Chris M Pillar
Candida infections vary in severity and manifestation. Common infections include invasive bloodstream infections among hospitalized/immunocompromised patients and vulvovaginal candidiasis among women. Echinocandins and azoles are commonly utilized to treat Candida infections, although echinocandin use has been restricted to indications amenable to once-daily IV administration. CD101, a novel echinocandin with a long plasma half-life and enhanced stability, is in development for once-weekly IV administration for the treatment of candidemia and invasive candidiasis...
July 21, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28807392/candidemia-and-colonization-by-candida-auris-a-diagnostic-challenge
#13
Lourdes Viñuela-Sandoval, Iker Falces-Romero, Julio García-Rodríguez, José María Eiros-Bouza
No abstract text is available yet for this article.
August 11, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28797491/candidemia-in-the-intensive-care-unit
#14
REVIEW
Oleg Epelbaum, Rachel Chasan
Candidemia presents several challenges to the intensive care unit (ICU) community. Recognition and treatment of this infection is frequently delayed, with dramatic clinical deterioration and death often preceding the detection of Candida in blood cultures. Identification of individual patients at the highest risk for developing candidemia remains an imperfect science; the role of antifungal therapy before culture diagnosis is yet to be fully defined in the ICU. The absence of well-established molecular techniques for early detection of candidemia hinders efforts to reduce the heavy clinical and economic impact of this infection...
September 2017: Clinics in Chest Medicine
https://www.readbyqxmd.com/read/28768479/evaluation-of-candidemia-in-epidemiology-and-risk-factors-among-cancer-patients-in-a-cancer-center-of-china-an-8-year-case-control-study
#15
Ding Li, Rui Xia, Qing Zhang, Changsen Bai, Zheng Li, Peng Zhang
BACKGROUND: Candidemia is the worldwide life-threaten disease, especially in cancer patients. This study was aimed to identify and evaluate the risk factors of candidemia in cancer patients, which will prompt the improvement on current therapeutic strategies and prognosis. METHODS: A retrospective, case-control study was conducted from inpatients of Tianjin Medical University Cancer Institute and Hospital, during 2006 to 2013. Analyses were performed between cancer patients with candidemia as study case, and patients with bacterial bloodstream infections as control...
August 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28750040/oral-administration-of-live-or-heat-killed-candida-albicans-worsened-cecal-ligation-and-puncture-sepsis-in-a-murine-model-possibly-due-to-an-increased-serum-1%C3%A2-3-%C3%AE-d-glucan
#16
Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Malcolm Finkelman, Navaporn Worasilchai, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul
Candida albicans is the most common fungus in the human intestinal microbiota but not in mice. To make a murine sepsis model more closely resemble human sepsis and to explore the role of intestinal C. albicans, in the absence of candidemia, in bacterial sepsis, live- or heat-killed C. albicans was orally administered to mice at 3h prior to cecal ligation and puncture (CLP). A higher mortality rate of CLP was demonstrated with Candida-administration (live- or heat-killed) prior to CLP. Fecal Candida presented only in experiments with live-Candida administration...
2017: PloS One
https://www.readbyqxmd.com/read/28744769/association-between-candiduria-and-candidemia-a-clinical-and-molecular-analysis-of-cases
#17
Maria Drogari-Apiranthitou, Ioannis Anyfantis, Irene Galani, Labrini Kanioura, Georgios L Daikos, Georgios Petrikkos
The risk of developing candidemia after candiduria is reportedly very low, but it has not been adequately investigated. The aim of this study was to examine the molecular relatedness between Candida strains isolated from adult patients with candidemia and concomitant candiduria in association with the clinical characteristics of the cases. All episodes of candidemia occurring in a tertiary care academic hospital during a 5-year period were recorded prospectively. Patients with episodes of candiduria occurring two weeks preceding to or one week following a positive for Candida blood culture were included in the study...
July 25, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28734712/-candidemia-in-pediatrics-species-distribution-and-antifungal-susceptibility
#18
Luciana B Guzzetti, Cecilia M Vescina, M Florencia Gil, Blanca M Gatti
Serious infections caused by Candida yeasts are frequent in the hospital population. Due to differences in species distribution and antifungal susceptibility testing depending on the geographic area and the type of patient, it is important to study the epidemiology of each institution. For this purpose, we conducted a retrospective, descriptive study on the occurrence of candidemia in the Children's Hospital "Superiora Sor María Ludovica" of the city of La Plata. In a 6-year period (2010-2015), 177 candidemia episodes were recorded...
July 19, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28729301/changes-in-the-incidence-and-mortality-of-candidemia-in-patients-with-hematological-malignancies-in-the-last-ten-years-seifem-2015-b-report
#19
Livio Pagano, Giulia Dragonetti, Chiara Cattaneo, Francesco Marchesi, Barbara Veggia, Alessandro Busca, Anna Candoni, Lucia Prezioso, Marianna Criscuolo, Simone Cesaro, Mario Delia, Rosa Fanci, Marta Stanzani, Antonella Ferrari, Bruno Martino, Lorella Melillo, Gianpaolo Nadali, Edoardo Simonetti, Stelvio Ballanti, Marco Picardi, Carlo Castagnola, Nunzia Decembrino, Marco Gazzola, Nicola Stefano Fracchiolla, Valentina Mancini, Annamaria Nosari, Maria Ilaria Del Principe, Franco Aversa, Mario Tumbarello
No abstract text is available yet for this article.
July 20, 2017: Haematologica
https://www.readbyqxmd.com/read/28703342/evaluation-of-direct-antifungal-susceptibility-testing-methods-of-candida-spp-from-positive-blood-culture-bottles
#20
Yasemin Oz, Egemen Gokbolat
BACKGROUND: Blood culture is the gold standard diagnostic method in candidemia in spite of long result time and low sensitivity rate. Early diagnosis is crucial for management of candidemia because a delay in treatment is related with increased mortality. We aimed to evaluate the direct applicability of antifungal susceptibility testing methods from positive blood culture bottles to save at least 24 hours. METHODS: Blood culture bottles were inoculated with 62 Candida isolates...
July 13, 2017: Journal of Clinical Laboratory Analysis
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