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Candidemia

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https://www.readbyqxmd.com/read/28729301/changes-in-the-incidence-and-mortality-of-candidemia-in-patients-with-hematological-malignancies-in-the-last-ten-years-seifem-2015-b-report
#1
Livio Pagano, Giulia Dragonetti, Chiara Cattaneo, Francesco Marchesi, Barbara Veggia, Alessandro Busca, Anna Candoni, Lucia Prezioso, Marianna Criscuolo, Simone Cesaro, Mario Delia, Rosa Fanci, Marta Stanzani, Antonella Ferrari, Bruno Martino, Lorella Melillo, Gianpaolo Nadali, Edoardo Simonetti, Stelvio Ballanti, Marco Picardi, Carlo Castagnola, Nunzia Decembrino, Marco Gazzola, Nicola Stefano Fracchiolla, Valentina Mancini, Annamaria Nosari, Maria Ilaria Del Principe, Franco Aversa, Mario Tumbarello
No abstract text is available yet for this article.
July 20, 2017: Haematologica
https://www.readbyqxmd.com/read/28703342/evaluation-of-direct-antifungal-susceptibility-testing-methods-of-candida-spp-from-positive-blood-culture-bottles
#2
Yasemin Oz, Egemen Gokbolat
BACKGROUND: Blood culture is the gold standard diagnostic method in candidemia in spite of long result time and low sensitivity rate. Early diagnosis is crucial for management of candidemia because a delay in treatment is related with increased mortality. We aimed to evaluate the direct applicability of antifungal susceptibility testing methods from positive blood culture bottles to save at least 24 hours. METHODS: Blood culture bottles were inoculated with 62 Candida isolates...
July 13, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28699797/candidemia-and-invasive-candidiasis-among-hospitalized-neonates-and-pediatric-patients
#3
Rachel Harrington, Sylvia L Kindermann, Qingjiang Hou, Robert J Taylor, Nkechi Azie, David L Horn
OBJECTIVE: To investigate the epidemiology, treatment, length of stay (LOS) and costs for neonatal and pediatric inpatients with invasive candidiasis (IC). METHODS: The Cerner Health Facts Database was used to assess inpatients (2005-2014) identified by positive blood or cerebrospinal fluid (CSF) Candida cultures. Log-transformed LOS and cost were examined in candidemia-only patients (n= 191) using multivariable linear regression. RESULTS: 202 patients had a positive culture (blood: n = 192; CSF: n = 10; both: n = 2)...
July 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28693479/pharmacoeconomic-analysis-of-antifungal-therapy-for-primary-treatment-of-invasive-candidiasis-caused-by-candida-albicans-and-non-albicans-candida-species
#4
Huang-Tz Ou, Tsung-Ying Lee, Yee-Chun Chen, Claudie Charbonneau
BACKGROUND: Cost-effectiveness studies of echinocandins for the treatment of invasive candidiasis, including candidemia, are rare in Asia. No study has determined whether echinocandins are cost-effective for both Candida albicans and non-albicans Candida species. There have been no economic evaluations that compare non-echinocandins with the three available echinocandins. This study was aimed to assess the cost-effectiveness of individual echinocandins, namely caspofungin, micafungin, and anidulafungin, versus non-echinocandins for C...
July 10, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28681025/candidemia-in-patients-with-prolonged-fever-in-kashan-iran
#5
R Razzaghi, M Momen-Heravi, M Erami, M Nazeri
BACKGROUND AND PURPOSE: Candida species are considered a common cause of fungal blood stream infections, which are associated with considerable mortality and morbidity rates, especially in the admitted and immunocompromised patients. Despite the increase in new and available antifungal agents, the emergence of resistant strains is growing. Regarding this, the aim of the present study was to assess the fungal epide-miology of candidemia and the antifungal susceptibility patterns against five current antifungal agents among the patients with prolonged fever, who were admitted to Beheshti Educational Hospital, Kashan, Iran...
September 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28680771/candida-pararugosa-first-reported-bloodstream-infection-in-an-adult
#6
Guy El Helou, Elizabeth Palavecino
Candida pararugosa is a yeast that has been previously isolated in various human specimens. The first reported isolation was from human feces in 1998, with subsequent reports of positive cultures from the oral cavity where it was thought to represent colonization rather than true infection. Though it has been isolated from other human sites, its clinical significance and manifestations are poorly characterized. We report the case of a 39-year-old woman on parenteral hyperalimentation who developed post abdominal surgery sepsis and surgical wound necrotizing fasciitis...
May 29, 2017: Curēus
https://www.readbyqxmd.com/read/28674314/candida-tropicalis-biofilm-formation-and-efficacy-of-liposomal-amphotericin-b-using-time-lapse-images
#7
Akira Kawai, Yuka Yamagishi, Hiroshige Mikamo
Candida species bloodstream infection such as candidemia remains a significant with high morbidity and mortality. Bloodstream infections caused by Candida species is often associated with the ability of Candida to form biofilms by using medical devices, such as central venous catheters. Non-albicans Candida species are increasing gradually in recent clinical practices. One of the Candida species, C. tropicalis, is likely to form biofilms and is also an independent risk factor with high morbidity and mortality in hospitalized patients...
July 1, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28669831/epidemiology-of-antifungal-resistance-in-human-pathogenic-yeasts-current-viewpoint-and-practical-recommendations-for-management
#8
Dimitrios Farmakiotis, Dimitrios P Kontoyiannis
In this review, we describe the epidemiology and clinical significance of resistance in Candida spp. and other non-Cryptococcus yeasts. The rise in echinocandin resistance, azole resistance and cross-resistance to ≥2 antifungal classes (multi-drug resistance: MDR) has been a worrisome trend, mainly in US large tertiary and oncology centers, particularly as it relates to C. glabrata. C. kefyr is also a concern, as it can be resistant to echinocandins and polyenes, especially in patients with hematologic malignancies...
June 29, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28651026/binding-of-human-plasminogen-and-high-molecular-mass-kininogen-by-cell-surface-exposed-proteins-of-candida-parapsilosis
#9
Justyna Karkowska-Kuleta, Dorota Zajac, Grazyna Bras, Oliwia Bochenska, Maria Rapala-Kozik, Andrzej Kozik
Pathogenic microbes can recruit to their cell surface human proteins that are components of important proteolytic cascades involved in coagulation, fibrinolysis and innate immune response. Once located at the bacterial or fungal surface, such deployed proteins might be utilized by pathogens to facilitate invasion and dissemination within the host organism by interfering with functionality of these systems or by exploiting specific activity of the bound enzymes. Aim of the study presented here was to characterize this phenomenon in Candida parapsilosis (Ashford) Langeron et Talice - an important causative agent of systemic fungal infections (candidiases and candidemias) in humans...
June 24, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28597394/invasive-candidiasis-in-brescia-italy-analysis-of-species-distribution-and-antifungal-susceptibilities-during-seven-years
#10
M A De Francesco, G Piccinelli, M Gelmi, F Gargiulo, G Ravizzola, G Pinsi, L Peroni, C Bonfanti, A Caruso
The aims of this study were to evaluate the epidemiology of nosocomial candidemia in a large teaching hospital in Brescia, Italy, and the in vitro antifungal susceptibility of isolates. We analyzed 196 isolates causing fungemia in patients admitted in our hospital, between January 2009 and December 2015. Strains were identified by VITEK 2 and MALDI-TOF MS. MICs were determined by Sensititre Yeast OneTM. The resistance was defined by using the revised CLSI breakpoints/epidemiological cutoff values to assign susceptibility or wild type to systemic antifungal agents...
June 8, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28587831/clinical-characteristics-and-risk-factors-for-mortality-in-adult-patients-with-persistent-candidemia
#11
Seung Ji Kang, Seong Eun Kim, Uh Jin Kim, Hee-Chang Jang, Kyung-Hwa Park, Jong Hee Shin, Sook In Jung
BACKGROUND: We investigated the clinical characteristics and risk factors for mortality in adults with persistent candidemia. METHODS: All patients ≥18 years old with candidemia in two Korean tertiary hospitals from 2007 to 2014 were investigated. Persistent candidemia was defined as isolation of the same Candida species ≥5 days after initiation of antifungal therapy. Non-persistent candidemia was defined as candidemia persisting for ≤3 days after initiation of antifungal therapy...
June 3, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28578431/antibodies-against-a-%C3%AE-glucan-protein-complex-of-candida-albicans-and-its-potential-as-indicator-of-protective-immunity-in-candidemic-patients
#12
Antonella Torosantucci, Mario Tumbarello, Carla Bromuro, Paola Chiani, Brunella Posteraro, Maurizio Sanguinetti, Roberto Cauda, Antonio Cassone
Sera from candidemic and non-candidemic subjects were examined for antibodies against the cell wall β1,3- and β1,6-glucans, as well as the β-glucan-associated protein MP65 of Candida species. Although antibodies against each of the above components were detected in all subjects, candidemic patients had lower antibody titers against β1,3-glucan, but higher antibody titers against β1,6-glucan and MP65, than non-candidemic subjects. The elevated levels of anti-β1,6-glucan and -MP65 antibodies found in candidemic patients were independent on the patient risk category, APACHE II score, presence of co-morbidities, β1,3-glucanemia level, Candida isolate, and antifungal treatment...
June 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28573191/invasive-candida-infections-in-liver-transplant-recipients-clinical-features-and-risk-factors-for-mortality
#13
Matteo Bassetti, Maddalena Peghin, Alessia Carnelutti, Elda Righi, Maria Merelli, Filippo Ansaldi, Cecilia Trucchi, Cristiano Alicino, Assunta Sartor, Joost Wauters, Katrien Lagrou, Carlo Tascini, Francesco Menichetti, Alessio Mesini, Francesco G De Rosa, Leonel Lagunes, Jordi Rello, Arnaldo L Colombo, Antonio Vena, Patricia Munoz, Mario Tumbarello, Gabriele Sganga, Ignacio Martin-Loeches, Claudio Viscoli
BACKGROUND: Invasive fungal infections remain a leading cause of morbidity and mortality among liver transplant recipients (LTRs). In this patient population, invasive Candida infections (ICIs) account for the large majority of cases. To date, only small studies and case-series analysing clinical presentation and risk factors for mortality in LTRs with ICIs are available. METHODS: We performed a retrospective multicenter multinational study in 10 centers in Europe and Brazil...
May 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28559266/an-immunomodulatory-peptide-that-confers-protection-in-an-experimental-candidemia-murine-model
#14
Camila G Freitas, Stella M F Lima, Mirna S Freire, Ana Paula C Cantuária, Nelson G O Júnior, Tatiane S Santos, Jéssica S Folha, Suzana M Ribeiro, Simoni C Dias, Taia M B Rezende, Patrícia Albuquerque, André M Nicola, César de la Fuente-Núñez, Robert E W Hancock, Octávio L Franco, Maria Sueli S Felipe
Fungal Candida species are commensals present in the mammalian skin and mucous membranes. Candida spp. are capable of breaching the epithelial barrier of immuno-compromised patients with neutrophil and cell-mediated immune dysfunctions, and it can also disseminate to multiple organs through the bloodstream. Here we examined the action of innate defence regulator (IDR)-1018, a 12-aminoacid residue peptide derived from bovine bactenecin (Bac2A), showed weak antifungal and anti-biofilm activity against C. albicans laboratory (ATCC 10231) and a clinical isolate (CI) strains (MICs of 32 μg...
May 30, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28540018/endogenous-endophthalmitis-after-severe-burn-a-case-report
#15
Seyedeh Maryam Hosseini, Ali Ahmadabadi, Seyed Hassan Tavousi, Majid Khadem Rezaiyan
PURPOSE: This report describes a rare ocular complication in a burned patient. CASE REPORT: A 12-year-old girl was admitted to our burn center because of full thickness burn of 46% of her total body surface area. On the 23(rd) day of her stay, she complained of pain and decreased visual acuity in the right eye. Examination of this eye revealed panuveitis, dense vitritis, and a large chorioretinal abscess in the macular area; her best corrected visual acuity (BCVA) in this eye was hand motion...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28527136/factors-influencing-non-albicans-candidemia-a-case-case-control-study
#16
Diamantis P Kofteridis, Antonis Valachis, Dimitra Dimopoulou, Angeliki M Andrianaki, Athanasia Christidou, Sofia Maraki, Nikolaos A Spernovasilis, George Samonis
The study identified factors predisposing to non-albicans candidemia with special interest to prior antimicrobial treatment. A retrospective, case-case-control study was performed at the University Hospital of Heraklion, Greece, from November 2007 through September 2011 including adult patients. The study had three groups. The first included 58 patients with non-albicans candidemia, the second 48 with C. albicans candidemia, while the third (control) 104 without candidemia. Each of the two candidemia groups was compared with the control using multivariate logistic regression model...
August 2017: Mycopathologia
https://www.readbyqxmd.com/read/28498297/gastrointestinal-colonization-of-candida-albicans-increases-serum-1%C3%A2-3-%C3%AE-d-glucan-without-candidemia-and-worsens-cecal-ligation-and-puncture-sepsis-in-murine-model
#17
Wimonrat Panpetch, Naraporn Somboonna, Dewi Embong Bulan, Jiraphorn Issara-Amphorn, Navaporn Worasilchai, Malcolm Finkelman, Ariya Chindamporn, Tanapat Palaga, Somying Tumwasorn, Asada Leelahavanichkul
The role of intestinal Candida albicans in bacterial sepsis, in the absence of candidemia, was investigated in murine models. Live C. albicans or normal saline solution (NSS) was administered orally once, followed by 5 days of daily oral antibiotic-mixtures (ATB). Cecal ligation and puncture (CLP) was then performed to induce sepsis.Fecal Candida was detected by culture only in models with Candida administration. Oral Candida administration with/without ATB enhanced gut-pathogenic bacteria as determined by microbiome analysis...
May 11, 2017: Shock
https://www.readbyqxmd.com/read/28493896/candidemia-in-the-elderly-what-does-it-change
#18
Francesco Barchiesi, Elena Orsetti, Sara Mazzanti, Francesca Trave, Aldo Salvi, Cinzia Nitti, Esther Manso
BACKGROUND: Candidemia is a life-threatening fungal infection and it can affect patients of all ages. Characterization of candidemia in the elderly is lacking. METHODS: We performed a retrospective study of adults (≥ 18 years) with candidemia diagnosed in our center in 2010-2015. Demographics, comorbidities, clinical and microbiologic characteristics, antifungal treatment and outcome were compared between older (≤65 years) and younger (>65 years) patients...
2017: PloS One
https://www.readbyqxmd.com/read/28469041/hepatosplenic-candidiasis-without-prior-documented-candidemia-an-underrecognized-diagnosis
#19
Joffrey van Prehn, C Willemien Menke-van der Houven van Oordt, Madelon L de Rooij, Ellen Meijer, Marije K Bomers, Karin van Dijk
INTRODUCTION: Patients with a history of chemotherapy or stem cell transplantation (SCT) and prolonged neutropenia are at risk for hepatic and/or splenic seeding of Candida. In our experience, hepatosplenic candidiasis (HSC) without documented candidemia often remains unrecognized. CASE PRESENTATIONS: We describe three cases of HSC without documented candidemia and the challenges in establishing the diagnosis and adequately treating this condition. The first patient had a history of SCT for treatment of breast cancer and was scheduled for hemihepatectomy for suspected liver metastasis...
May 3, 2017: Oncologist
https://www.readbyqxmd.com/read/28444360/role-of-early-onset-neutropenia-in-development-of-candidemia-in-premature-infants
#20
Nermin Ramy, Mohamed Hashim, Heba Abou Hussein, Happy Sawires, Maha Gaafar, Ayat El Maghraby
Background: The aim of the study was to assess the effect of early-onset neutropenia (EON) on the development of candidemia in premature infants and evaluate other risk factors. Materials and Methods: This prospective study was carried out in a neonatal intensive care unit of Cairo University Hospital. Fifty neutropenic premature infants were matched to 50 non-neutropenics. Subjects were then regrouped into candidemics and non-candidemics to study other risk factors such as central venous catheters, mechanical ventilation, parenteral nutrition, drugs as corticosteroids and others...
April 24, 2017: Journal of Tropical Pediatrics
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