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Kaitlin Benedict, Monika Roy, Sarah Kabbani, Evan J Anderson, Monica M Farley, Sasha Harb, Lee H Harrison, Lindsay Bonner, Vijitha Lahanda Wadu, Kaytlyn Marceaux, Rosemary Hollick, Zintar G Beldavs, Alexia Y Zhang, William Schaffner, Caroline R Graber, Gordana Derado, Tom M Chiller, Shawn R Lockhart, Snigdha Vallabhaneni
Introduction: Candida is a leading cause of healthcare-associated bloodstream infections in the United States. Infants and children have unique risk factors for candidemia, and the Candida species distribution in this group is different that among adults; however, candidemia epidemiology in this population has not been described recently. Methods: We conducted active population-based candidemia surveillance in 4 US metropolitan areas between 2009 and 2015. We calculated incidences among neonates (0-30 days old), infants (0-364 days old), and noninfant children (1-19 years old), documented their clinical features and antifungal drug resistance...
March 7, 2018: Journal of the Pediatric Infectious Diseases Society
Hiroshi Kakeya, Koichi Yamada, Yukihiro Kaneko, Katsunori Yanagihara, Kazuhiro Tateda, Shigefumi Maesaki, Yoshio Takesue, Kazunori Tomono, Jun-Ichi Kadota, Mitsuo Kaku, Yoshitsugu Miyazaki, Katsuhiko Kamei, Kazutoshi Shibuya, Yoshitiho Niki, Minoru Yoshida, Yoshihiro Sei
The Epidemiological Investigation Committee for Human Mycoses in Japan performed a retrospective epidemiological survey of candidemia and causative Candida species. Data from 2003 to 2014 were collected from 10 Japanese university hospitals. A total of 328,318 blood cultures were included. The prevalence of fungi in all cultures and in positive cultures were 0.58±0.09% and 4.46±0.66%, respectively. Among the results that were positive for Candida species (N=1,921), Candida albicans was the most common species (39...
2018: Medical Mycology Journal
Francisco Márquez, Isabel Iturrieta, Mario Calvo, Milton Urrutia, Patricio Godoy-Martínez
BACKGROUND: Candidemia disease in Chile is not very known, despite being a very common and serious disease. AIM: To analyze incidence and susceptibility profile of species from the genus Candida in Hospital Base Valdivia. MATERIAL AND METHODS: All candidemia cases presented between March 2009 and August 2011 in our institution were identified. Species distribution and susceptibility were studied through the disk diffusion method. RESULTS: Twenty-seven candidemia episodes were studied...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Iris Nora Tiraboschi, Natalia Cintia Pozzi, Luciana Farías, Susana García, Norma Beatriz Fernández
BACKGROUND: The epidemiology of candidemia vary by region. AIM: To determine the epidemiology of candidemia in a hospital for 16 years. MATERIAL AND METHODS: Episodes of candidemia occurred in the Hospital de Clinicas of Buenos Aires were reviewed, from 01/01/98 to 31/12/13. RESULTS: 374 episodes of candidemia were identified. The incidence was 2.21/1,000 discharges and increased from 1.96 (1998-2005) to 2.25 (2006-2013) (p = 0...
October 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Malgorzata Anna Dawgul, Daria Grzywacz, Beata Liberek, Wojciech Kamysz, Henryk Myszka
BACKGROUND: Candida albicans belongs to the most common fungal pathogens in humans, but recently an increased proliferation of strains called non-albicans Candida has been report-ed. Species belonging to this group are often characterised by a reduced susceptibility to anti-fungal agents. OBJECTIVE: In view of the emergence of non-albicans Candida and their resistance to available antifungals, an attempt has been made to develop novel effective agents. Biological activities of the N,N-dialkyl diosgenyl glycosides, which were previously synthesized, were determined...
February 26, 2018: Medicinal Chemistry
Simone Cesaro, Gloria Tridello, Nicole Blijlevens, Per Ljungman, Charles Craddock, Mauricette Michallet, Alexander Martin, John A Snowden, Mohamad Mohty, Johan Maertens, Jacob Passweg, Eefke Petersen, Anne Nihtinen, Cecilia Isaksson, Noel Milpied, Pierre-Simon Rohlich, Eric Deconinck, Charles Crawley, Marie-Pierre Ledoux, Jennifer Hoek, Arnon Nagler, Jan Styczynski
Objectives: To assess the incidence of, and risk factors for, Candida infection in the first 100 days after allogeneic hematopoietic stem cell transplantation (HSCT) and the impact on long-term survival. Methods: outcome analysis of 28,542 acute leukemia patients who underwent HSCT from 2000 to 2012: 347 with candidemia by day +100, and 28,195 without candidemia or any other type of Candida infection. Results: The incidence of candidemia by day +100 was 1...
February 22, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
John E Bennett, John H Powers
No abstract text is available yet for this article.
March 2018: Critical Care Medicine
Lauro Damonti, Véronique Erard, Jorge Garbino, Jacques Schrenzel, Stefan Zimmerli, Konrad Mühlethaler, Alexander Imhof, Reinhard Zbinden, Jan Fehr, Katia Boggian, Thomas Bruderer, Ursula Flückiger, Reno Frei, Christina Orasch, Anna Conen, Nina Khanna, Thomas Bregenzer, Jacques Bille, Frédéric Lamoth, Oscar Marchetti, Pierre-Yves Bochud
In the original publication the members of the FUNGINOS network were provided in such a way that they could not be indexed as collaborators on PubMed.
February 20, 2018: Intensive Care Medicine
Cornelius J Clancy, M Hong Nguyen
Blood cultures are positive for Candida species in < 50% and < 20% of hematogenously disseminated and intra-abdominal candidiasis, respectively. Non-culture tests such as mannan, anti-mannan antibody, Candida albicans germ tube antibody (CAGTA), 1,3-β-d-glucan (BDG), the T2Candida nanodiagnostic panel, and polymerase chain reaction (PCR) are available for clinical use, but their roles in patient care are uncertain. Sensitivity/specificity of combined mannan/anti-mannan, BDG, T2Candida and PCR for candidemia are ~80%/80%, ~80%/80%, ~90%/98%, and ~90%/90%, respectively...
February 19, 2018: Journal of Fungi (Basel, Switzerland)
Zinnat Shahina, Amira M El-Ganiny, Jessica Minion, Malcolm Whiteway, Taranum Sultana, Tanya E S Dahms
Background: Cinnamon ( Cinnamomum zeylanicum) bark extract exhibits potent inhibitory activity against Candida albicans but the antifungal mechanisms of this essential oil remain largely unexplored. Results: We analyzed the impact of cinnamon bark oil on C. albicans RSY150, and clinical strains isolated from patients with candidemia and candidiasis. The viability of RSY150 was significantly compromised in a dose dependent manner when exposed to cinnamon bark oil, with extensive cell surface remodelling at sub inhibitory levels (62...
2018: Fungal Biology and Biotechnology
Adnan Alatoom, Mohammad Sartawi, Karen Lawlor, Laila AbdelWareth, Jens Thomsen, Ahmad Nusair, Imran Mirza
In this case, we report an elderly patient with multiple chronic conditions and prolonged intensive care units (ICU) stay who had recurrent Candida auris (C. auris) in blood despite antifungal therapy. C. auris was misidentified using conventional automated identification system as Candida haemulonii resulting in delayed diagnosis. The isolate showed increasing minimum inhibitory concentrations (MICs) to different antifungal drugs and persisted in the patient's blood before the patient deceased. This is the first case of C...
February 13, 2018: International Journal of Infectious Diseases: IJID
Cornelius J Clancy, M Hong Nguyen
Cultures are negative in ∼50% of invasive candidiasis. Data are emerging for the performance of non-culture tests like mannan/anti-mannan, Candida albicans germ tube antibody, 1,3-β-D-glucan, polymerase chain reaction, and the T2Candida panel in diagnosing both candidemia and deep-seated candidiasis. In most settings, positive predictive values of non-culture test are low, and negative predictive values are high. For tests to be useful, clinicians must understand the pre-test likelihood of invasive candidiasis and test performance for the most common disease manifestation in a given patient...
February 14, 2018: Journal of Clinical Microbiology
H Bradford Hawley
No abstract text is available yet for this article.
February 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Cornelius J Clancy, Peter G Pappas, Jose Vazquez, Marc A Judson, Dimitrios P Kontoyiannis, George R Thompson, Kevin W Garey, Annette Reboli, Richard N Greenberg, Senu Apewokin, G Marshall Lyon, Luis Ostrosky-Zeichner, Alan H B Wu, Ellis Tobin, M Hong Nguyen, Angela M Caliendo
Background: Blood cultures are approximately 50% sensitive for diagnosing invasive candidiasis. The T2Candida nanodiagnostic panel uses T2 magnetic resonance and a dedicated instrument to detect Candida directly within whole blood samples. Methods: Patients with Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, or Candida krusei candidemia were identified at 14 centers using diagnostic blood cultures (dBCs). Follow-up blood samples were collected concurrently for testing by T2Candida and companion cultures (cBCs)...
February 9, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
J Guitard, F Isnard, M-D Tabone, M Antignac, E Brissot, Y Senghor, A Petit, G Leverger, C Hennequin
OBJECTIVES: Definitive diagnosis of invasive candidiasis (IC) may be difficult to achieve in patients with haematological malignancy (PHM). We aimed to evaluate the performance of BDG for the diagnosis and the follow-up of IC in PHM. PATIENTS AND METHODS: We retrospectively reviewed the serological data of BDG assay in adult and paediatric PHM, who developed candidemia or chronic disseminated candidiasis (CDC) through a 4-year period. Sensitivity and kinetics of BDG were determined for both clinical forms...
February 9, 2018: Journal of Infection
Bruna Lavezzo, Damiano Patrono, Francesco Tandoi, Silvia Martini, Fabrizio Fop, Valentina Ballerini, Chiara Stratta, Stefano Skurzak, Francesco Lupo, Paolo Strignano, Pier Paolo Donadio, Mauro Salizzoni, Renato Romagnoli, Francesco Giuseppe De Rosa
Invasive fungal infection (IFI) is a severe complication of liver transplantation burdened by high mortality. Guidelines recommend targeted rather than universal antifungal prophylaxis based on tiers of risk METHODS: We aimed to evaluate IFI incidence, risk factors and outcome after implementation of a simplified two-tiered targeted prophylaxis regimen based on a single broad-spectrum antifungal drug (amphotericin B). Patients presenting one or more risk factors according to literature were administered prophylaxis...
February 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Giovanni L Breda, Felipe F Tuon, Jacques F Meis, Patricia F Herkert, Ferry Hagen, Letícia Z de Oliveira, Viviane de Carvalho Dias, Clóvis Arns da Cunha, Flávio Queiroz-Telles
Candidemia is the main invasive fungal disease among hospitalized patients. Several breakthrough candidemia (BrC) cases have been reported, but few studies evaluate the epidemiology, risk factors, molecular characterization, antifungal susceptibility profile and outcome of those patients, especially in developing countries and including patients using broad spectrum antifungals. We conducted a retrospective study from 2011 to 2016, including patients aged 12 years or older with candidemia. Epidemiological characteristics and risk factors for candidemia were evaluated and compared with patients with BrC using univariate and multivariate analysis...
October 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Patricia Muñoz, Caroline Agnelli, Jesús Guinea, Antonio Vena, Ana Alvarez-Uria, Laura Judith Marcos-Zambrano, Pilar Escribano, Maricela Valerio, Emilio Bouza
OBJECTIVES: The role of biofilm production in the outcome of candidemia remains under discussion. Current evidence relies on variable biofilm detection methods while evaluating distinct clinical endpoints. We aimed to determine the impact of biofilm production measured by metabolic activity (MA) and biomass (BM) on the prognosis of adults with candidemia. METHODS: Retrospective cohort including 280 adults with candidemia admitted from 2010 to 2016. BM was assessed using crystal violet binding stain and the XTT reduction assay was used to detect MA...
February 2, 2018: Clinical Microbiology and Infection
R Spiers, B Smyth, T Lamagni, P Rooney, E Dorgan, T Wyatt, L Geoghegan, L Patterson
In Northern Ireland there are concerns about candidaemia, with rates higher than those reported in England and Wales. Our aim was to explore the epidemiology of candidaemia during a 10 year period and the clinical management upon suspicion of cases during a one year enhanced investigation in Northern Ireland.Candidaemia reports to the Public Health Agency were validated during 2002-2011 and used to examine incidence and antifungal sensitivity trends (during 2007-2011). A clinical proforma was used to collate information for all patients with candidaemia in 2011...
January 29, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
Ratna Mohd Tap, Teck Choon Lim, Nur Amalina Kamarudin, Stephanie Jane Ginsapu, Mohd Fuat Abd Razak, Norazah Ahmad, Fairuz Amran
We report a fatal case of Candida auris that was involved in mixed candidemia with Candida tropicalis, isolated from the blood of a neutropenic patient. Identification of both isolates was confirmed by amplification and sequencing of internal transcribed spacer and D1/D2 domain of large subunit in rRNA gene. Antifungal susceptibility test by E-test method revealed that C. auris was resistant to amphotericin B, anidulafungin, caspofungin, fluconazole, itraconazole and voriconazole. On the other hand, C. tropicalis was sensitive to all antifungal tested...
January 30, 2018: Mycopathologia
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