Fernando Cartón-García, Bruno Brotons, Estefanía Anguita, Higinio Dopeso, Jordi Tarragona, Rocio Nieto, Elia García-Vidal, Irati Macaya, Zsuzsanna Zagyva, Mariona Dalmau, Manuel Sánchez-Martín, Sven C D van Ijzendoorn, Stefania Landolfi, Javier Hernandez-Losa, Simo Schwartz, Xavier Matias-Guiu, Santiago Ramón Y Cajal, Águeda Martínez-Barriocanal, Diego Arango
Colorectal cancer causes >900,000 deaths every year and a deeper understanding of the molecular mechanisms underlying this disease will contribute to improve its clinical management and survival. Myosin Vb (MYO5B) regulates intracellular vesicle trafficking, and inactivation of this myosin disrupts the polarization and differentiation of intestinal epithelial cells causing microvillous inclusion disease (MVID), a rare congenital disorder characterized by intractable life-threatening diarrhea. Here, we show that the loss Myosin Vb interfered with the differentiation/polarization of colorectal cancer cells...
November 1, 2022: Oncogene