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https://www.readbyqxmd.com/read/28109205/haloterrigena-mahii-sp-nov-an-extreme-halophilic-archaeon-from-the-solar-saltern
#1
Jiun-Yan Ding, Sheng-Chung Chen, Mei-Chin Lai, Tsai-Ling Liao
A pleomorphic, gas vesicle containing, halophilic archaeon, designated strain H13T, was isolated from the solar saltern of the Western Salt Co., Chula Vista, California, USA. Cells of strain H13T were non-motile, rod-shaped and 3-10 μm in length. The optimum growth conditions were 3.5-5.0 M NaCl, 45-55 oC, and pH range of 6.5-8.2. The major polar lipids were C20C20 and C20C25 derivatives of phosphatidylglycerol (PG), phosphatidylglycerol phosphate methyl ester (PGP-Me) and disulfated diglycosyl diether-1 (S2-DGD-1)...
January 21, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28109202/algoriphagus-resistens-sp-nov-isolated-from-marine-sediment
#2
Ji-Ru Han, Jin-Xin Zhao, Zong-Jie Wang, Guan-Jun Chen, Zong-Jun Du
Strain NH1T, a pink-pigmented, facultatively anaerobic, heterotrophic, catalase-positive and oxidase-negative, Gram-stain-negative marine bacterium, was isolated from marine sediment in the coast of Weihai, China. Cells of strain NH1T was rod-shaped, 0.8-2.0 µm in length and 0.5 µm in width. The strain able to grow at 13-37 °C, pH 5.5-8.5, in the presence of 0.0-8.0% (w/v) NaCl. Optimal growth was observed at 28 °C, with 3.0% (w/v) NaCl and pH 6.5-7.0. Nitrate was reduced. The G+C content of the DNA was 41...
January 19, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/28109146/-cloning-expression-and-activity-identification-of-human-innate-immune-protein-apolipoprotein-b-mrna-editing-enzyme-catalytic-subunit-3a-apobec3a
#3
Shan Cheng, Liyan Cao, Juan Du, Wenyong Wang, Yanhai Guo
Objective To construct the expression vector of apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A), express APOBEC3A in eukaryotic cells and identify its cytosine deaminase activity. Methods The APOBEC3A gene was obtained by PCR and inserted into the eukaryotic expression vector pcDNA3.0(+). The recombinant vector pcDNA3.0-APOBEC3A was then transfected into HEK293T and HepG2 cells after confirmed by DNA sequencing. The recombinant protein was purified by Ni-NTA HisBind affinity column. Western blot analysis was used to detect the expression of APOBEC3A protein...
February 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28108961/effects-of-negatively-and-positively-charged-ti-metal-surfaces-on-ceramic-coating-adhesion-and-cell-response
#4
Rodney Marcelo do Nascimento, Vanessa Rafaela de Carvalho, José Silvio Govone, Antônio Carlos Hernandes, Nilson Cristino da Cruz
This manuscript reports an evaluation of the effects of simple chemical-heat treatments on the deposition of different ceramic coatings, i.e., TiO2, CaTiO3 and CaP, on commercially pure titanium (cp-Ti) and Ti6Al4V and the influence of the coatings on cells interaction with the surfaces. The ceramic materials were prepared by the sol-gel method and the coating adhesion was analyzed by pull-off bending tests. The wettability of positively or negatively charged surfaces was characterized by contact angle measurements, which also enabled the calculation of the surface free energy through the polar-apolar liquids approach...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28108629/myeloid-stat3-promotes-lung-tumorigenesis-by-transforming-tumor-immunosurveillance-into-tumor-promoting-inflammation
#5
Jingjiao Zhou, Zhaoxia Qu, Fan Sun, Lei Han, Liwen Li, Shapei Yan, Laura P Stabile, Lin-Feng Chen, Jill M Siegfried, Gutian Xiao
One of the most fundamental and challenging questions in the cancer field is how immunity in cancer patients is transformed from tumor immunosurveillance to tumor-promoting inflammation. Here, we identify the transcription factor STAT3 as the culprit responsible for this pathogenic event in lung cancer development. We found that antitumor type 1 CD4(+) T helper (Th1) cells and CD8(+) T cells were directly counter-balanced in lung cancer development with tumor-promoting myeloid-derived suppressor cells (MDSCs) and suppressive macrophages, and that activation of STAT3 in MDSCs and macrophages promoted tumorigenesis through pulmonary recruitment and increased resistance of suppressive cells to CD8(+) T cells, enhancement of cytotoxicity towards CD4(+) and CD8(+) T cells, induction of regulatory T cell (Treg), inhibition of dendritic cells (DCs), and polarization of macrophages toward the M2 phenotype...
January 20, 2017: Cancer Immunology Research
https://www.readbyqxmd.com/read/28108476/dynamic-analysis-of-the-mesenchymal-epithelial-transition-of-blood-brain-barrier-forming-glia-in-drosophila
#6
Tina Schwabe, Xiaoling Li, Ulrike Gaul
During development, many epithelia are formed by a mesenchymal-epithelial transition (MET). Here, we examine the major stages and underlying mechanisms of MET during blood-brain barrier formation in Drosophila We show that contact with the basal lamina is essential for the growth of the barrier-forming subperineurial glia (SPG). Septate junctions (SJs), which provide insulation of the paracellular space, are not required for MET, but are necessary for the establishment of polarized SPG membrane compartments...
January 20, 2017: Biology Open
https://www.readbyqxmd.com/read/28108274/the-crosstalk-between-wnt-%C3%AE-catenin-signaling-pathway-with-dna-damage-response-and-oxidative-stress-implications-in-cancer-therapy
#7
REVIEW
Ansar Karimaian, Maryam Majidinia, Hossein Bannazadeh Baghi, Bahman Yousefi
DNA repair is essential for maintaining genomic integrity in cells. The dependence of cancer cell survival on proper DNA repair provides an opportunity to treat defective tumors by DNA damaging agents. Not only Wnt signaling has important functions in controlling gene expression, as well as cell polarity, adhesion and behavior, it also highly interacts with DNA damage response (DDR) in different levels. Furthermore, oxidative stress, which is responsible for majority of DNA lesions, affects Wnt signaling in different ways...
January 11, 2017: DNA Repair
https://www.readbyqxmd.com/read/28106295/macrophage-polarization-anti-cancer-strategies-to-target-tumor-associated-macrophage-in-breast-cancer
#8
Muhammad Tariq, Jieqiong Zhang, Guikai Liang, Ling Ding, Qiaojun He, Bo Yang
Tumor-associated macrophages (TAMs) are the most abundant inflammatory cells and orchestrate different stages of breast cancer development. TAMs participate in the tumor angiogenesis, matrix remodeling, invasion, immunosuppression, metastasis, and chemoresistance in breast cancer. Several clinical studies indicate the association between the high influx of TAMs in tumor with poor prognosis in hepatocellular, ovarian, cervical, and breast cancer. Previously developed hypotheses have proposed that TAMs participate in antitumor responses of the body, while recently many clinical and experimental studies have revealed that TAMs in tumor microenvironment predominantly resemble with M2-like polarized macrophages and produce a high amount of anti-inflammatory factors which are directly responsible for the development of tumor...
January 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28106146/asymmetric-waveforms-decrease-lethal-thresholds-in-high-frequency-irreversible-electroporation-therapies
#9
Michael B Sano, Richard E Fan, Lei Xing
Irreversible electroporation (IRE) is a promising non-thermal treatment for inoperable tumors which uses short (50-100 μs) high voltage monopolar pulses to disrupt the membranes of cells within a well-defined volume. Challenges with IRE include complex treatment planning and the induction of intense muscle contractions. High frequency IRE (H-FIRE) uses bursts of ultrashort (0.25-5 μs) alternating polarity pulses to produce more predictable ablations and alleviate muscle contractions associated with IRE...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28106090/broadband-and-broad-angle-polarization-independent-metasurface-for-radar-cross-section-reduction
#10
Hengyi Sun, Changqing Gu, Xinlei Chen, Zhuo Li, Liangliang Liu, Bingzheng Xu, Zicheng Zhou
In this work, a broadband and broad-angle polarization-independent random coding metasurface structure is proposed for radar cross section (RCS) reduction. An efficient genetic algorithm is utilized to obtain the optimal layout of the unit cells of the metasurface to get a uniform backscattering under normal incidence. Excellent agreement between the simulation and experimental results show that the proposed metasurface structure can significantly reduce the radar cross section more than 10 dB from 17 GHz to 42 GHz when the angle of incident waves varies from 10° to 50°...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105525/characterization-of-the-cell-polarity-gene-crumbs-during-the-early-development-and-maintenance-of-the-squid-vibrio-light-organ-symbiosis
#11
Suzanne M Peyer, Elizabeth A C Heath-Heckman, Margaret J McFall-Ngai
The protein Crumbs is a determinant of apical-basal cell polarity and plays a role in apoptosis of epithelial cells and their protection against photodamage. Using the squid-vibrio system, a model for development of symbiotic partnerships, we examined the modulation of the crumbs gene in host epithelial tissues during initiation and maintenance of the association. The extracellular luminous symbiont Vibrio fischeri colonizes the apical surfaces of polarized epithelia in deep crypts of the Euprymna scolopes light organ...
January 20, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28105505/frankia-discariae-sp-nov-an-infective-and-effective-microsymbiont-isolated-from-the-root-nodule-of-discaria-trinervis
#12
Imen Nouioui, Maria Del Carmen Montero-Calasanz, Faten Ghodhbane-Gtari, Manfred Rohde, Louis S Tisa, Hans-Peter Klenk, Maher Gtari
Strain BCU110501(T) was the first isolate reported to fulfill Koch's postulates by inducing effective nodules on its host plant of origin Discaria trinervis (Rhalmnaceae). Based on 16S rRNA gene sequence similarities, the strain was found to be most closely related to the type strain of Frankia elaeagni DSM 46783(T) (98.6%) followed by F. alni DSM 45986(T) (98.2%), F. casuarinae DSM 45818(T) (97.8%) and F. inefficacies DSM 45817(T) (97.8%). Digital DNA:DNA hybridizations (dDDH) between strain BCU110501(T)and the type strains of other Frankia species were clearly below the cutoff point of 70%...
January 19, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/28105394/piezo-phototronic-effect-enhanced-flexible-solar-cells-based-on-n-zno-p-sns-core-shell-nanowire-array
#13
Laipan Zhu, Longfei Wang, Fei Xue, Libo Chen, Jianqiang Fu, Xiaolong Feng, Tianfeng Li, Zhong Lin Wang
The piezo-phototronic effect is about the enhanced separation, transport, and recombination of the photogenerated carriers using the piezoelectric polarization charges present in piezoelectric-semiconductor materials. Here, it is presented that the piezo-phototronic effect can be effectively applied to improve the relative conversion efficiency of a flexible solar cell based on n-ZnO/p-SnS core-shell nanowire array for 37.3% under a moderate vertical pressure. The performance of the solar cell can be effectively enhanced by a gentle bending of the device, showing its potential for application in curly geometries...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28105255/pi3k-ship2-pten-pathway-in-cell-polarity-and-hepatitis-c-virus-pathogenesis
#14
REVIEW
Aline Awad, Ama Gassama-Diagne
Hepatitis C virus (HCV) infects hepatocytes, polarized cells in the liver. Chronic HCV infection often leads to steatosis, fibrosis, cirrhosis and hepatocellular carcinoma, and it has been identified as the leading cause of liver transplantation worldwide. The HCV replication cycle is dependent on lipid metabolism and particularly an accumulation of lipid droplets in host cells. Phosphoinositides (PIs) are minor phospholipids enriched in different membranes and their levels are tightly regulated by specific PI kinases and phosphatases...
January 8, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28105194/biomarkers-for-emt-and-met-in-breast-cancer-an-update
#15
Fei Liu, Li-Na Gu, Bao-En Shan, Cui-Zhi Geng, Mei-Xiang Sang
Metastasis and recurrence are the leading cause of mortality due to breast cancer, but the underlying mechanisms are still poorly understood. Understanding the breast cancer metastasis mechanism is important for early diagnosis and treatment of breast cancer. The seeding and growth of breast cancer cells at sites distinct from the primary tumor is a complex and multistage process. Recently, it has been reported that the epithelial-mesenchymal transition (EMT) and the mesenchymal-epithelial transition (MET) are the main mechanisms for breast cancer metastasis...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28104473/hyperlipidaemia-alone-and-in-combination-with-acidosis-can-increase-the-incidence-and-severity-of-statin-induced-myotoxicity
#16
Dhiaa A Taha, Atheer Zgair, Jong Bong Lee, Cornelia H de Moor, David A Barrett, Kimberley D Bruce, Mitchell Sungelo, Robert H Eckel, Pavel Gershkovich
The association of lipophilic statins with plasma lipoproteins in the presence of disturbed acid-base balance can modify the pharmacokinetics and tissue distribution of these drugs, resulting in alteration in their efficacy and toxicity profiles. The purpose of this study is to elucidate the role of hyperlipidaemia alone or in combination with acidosis/alkalosis in the development and potentiation of statin-induced myotoxicity. Statins association with plasma lipoproteins was examined under conditions of physiological and altered pH levels...
January 16, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28103528/topical-vaccination-with-super-stable-ready-to-use-nanovesicles
#17
Ayelen Tatiana Caimi, Federico Parra, Marcelo Alexander de Farias, Rodrigo Villares Portugal, Ana Paula Perez, Eder Lilia Romero, Maria Jose Morilla
Ultradeformable archaeosomes (UDA) are nanovesicles made of total polar archaeolipids (TPA) from the archaea Halorubrum tebenquichense, soybean phosphatidylcholine and sodium cholate (3:3:1w/w). Fresh dispersions of UDA including different type of antigens are acknowledged as efficient topical vaccination agents. UDA dispersions however, if manufactured for pharmaceutical use, have to maintain colloidal stability upon liposomicidal processes such as sterilization and lyophilization (SLRUDA), needed to extend shelf life during storage...
December 26, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103296/production-of-fatty-acids-and-protein-by-nannochloropsis-in-flat-plate-photobioreactors
#18
Chris J Hulatt, René H Wijffels, Sylvie Bolla, Viswanath Kiron
Nannochloropsis is an industrially-promising microalga that may be cultivated for alternative sources of nutrition due to its high productivity, protein content and lipid composition. We studied the growth and biochemical profile of Nannochloropsis 211/78 (CCAP) in optimized flat-plate photobioreactors. Eighteen cultivations were performed at two nutrient concentrations. The fatty acid, protein content and calorific values were analyzed after 8, 12 and 16 days. Neutral lipids were separated and the changes in fatty acids in triglycerides (TAGs) during nutrient depletion were recorded...
2017: PloS One
https://www.readbyqxmd.com/read/28102411/defect-driven-shapes-in-nematic-droplets-analogies-with-cell-division
#19
Marco Leoni, Oksana V Manyuhina, Mark J Bowick, M Cristina Marchetti
Building on the striking similarity between the structure of the spindle during mitosis in living cells and nematic textures in confined liquid crystals, we use a continuum model of two-dimensional nematic liquid crystal droplets to examine the physical aspects of cell division. The model investigates the interplay between bulk elasticity of the microtubule assembly, described as a nematic liquid crystal, and surface elasticity of the cell cortex, modeled as a bounding flexible membrane, in controlling cell shape and division...
January 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28102310/coordinated-cell-motility-is-regulated-by-a-combination-of-lkb1-farnesylation-and-kinase-activity
#20
S Wilkinson, Y Hou, J T Zoine, J Saltz, C Zhang, Z Chen, L A D Cooper, A I Marcus
Cell motility requires the precise coordination of cell polarization, lamellipodia formation, adhesion, and force generation. LKB1 is a multi-functional serine/threonine kinase that associates with actin at the cellular leading edge of motile cells and suppresses FAK. We sought to understand how LKB1 coordinates these multiple events by systematically dissecting LKB1 protein domain function in combination with live cell imaging and computational approaches. We show that LKB1-actin colocalization is dependent upon LKB1 farnesylation leading to RhoA-ROCK-mediated stress fiber formation, but membrane dynamics is reliant on LKB1 kinase activity...
January 19, 2017: Scientific Reports
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