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https://www.readbyqxmd.com/read/28926234/using-ultra-performance-liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry-based-chemometrics-for-the-identification-of-anti-angiogenic-biflavonoids-from-edible-garcinia-species
#1
Ping Li, Grace Gar-Lee Yue, Hin-Fai Kwok, Chun-Lin Long, Clara Bik-San Lau, Edward J Kennelly
Garcinia xanthochymus fruits are edible and also used in traditional medicine. Our previous work showed that the isolated natural products from G. xanthochymus fruits have displayed antioxidant activity and cytotoxicity in the colon cancer cells. In this study, we developed a strategy to correlate a zebrafish angiogenesis assay with ultra-performance liquid chromatography quadrupole time of flight mass spectrometry-based chemometric analysis to identify potential anti-angiogenic activity compounds from G. xanthochymus fruits...
September 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28924359/brazilian-orthopedists-opinions-and-perceptions-on-femoroacetabular-impingement
#2
Leandro Ejnisman, Moin Khan, Olufemi Rolland Ayeni, Mohit Bhandari, Helder de Souza Miyahara, Jose Ricardo Negreiros Vicente
OBJECTIVE: To assess the opinion of Brazilian orthopedists surgeons on the diagnosis and treatment of femoroacetabular impingement (FAI). METHODS: A questionnaire was sent to several orthopedic societies around the world, including the Sociedade Brasileira de Ortopedia e Traumatologia (SBOT). This questionnaire was sent electronically and included questions on many topics related to FAI. RESULTS: 253 Brazilian orthopedists responded the questionnaire...
November 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28922714/atmospheric-levels-and-cytotoxicity-of-polycyclic-aromatic-hydrocarbons-and-oxygenated-pahs-in-pm2-5-in-the-beijing-tianjin-hebei-region
#3
Xinyi Niu, Steven Sai Hang Ho, Kin Fai Ho, Yu Huang, Jian Sun, Qiyuan Wang, Yaqing Zhou, Zhuzi Zhao, Junji Cao
The chemical composition of PM2.5 and cellular effects from exposure to fine aerosol extracts were studied for samples collected in Beijing, Tianjin, Shijiazhuang, and Hengshui, China in winter 2015. Effects of priority polycyclic aromatic hydrocarbons (PAHs) and their oxygenated derivatives (OPAHs) in PM2.5 on cell cultures were a major focus of the study. Total quantified PAHs and OPAHs at Shijiazhuang and Hengshui were higher than at Beijing and Tianjin, and benz(a)anthracene, chrysene and 1,8-naphthalic anhydride were the most abundant species...
September 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28918676/cross-cultural-adaptation-and-psychometric-properties-of-the-chinese-tinnitus-functional-index
#4
Anna Chi Shan Kam, Eric Kwok Shun Leung, Patrick Yiu Bong Chan, Michael Chi Fai Tong
OBJECTIVES: To establish the reliability, validity and responsiveness of the Chinese version of the Tinnitus Functional Index (TFI-CH) in measuring tinnitus severity in Hong Kong Chinese population. DESIGN: This is a cross-sectional psychometric validation study. STUDY SAMPLE: Subjects were 124 adult Chinese who attended the audiology clinics in a hospital setting for tinnitus treatment. RESULTS: The TFI-CH showed good internal consistency reliability (α = 0...
September 18, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28915523/-biologic-reconstruction-of-full-sized-cartilage-defects-of-the-hip-a-guideline-from-the-dgou-group-clinical-tissue-regeneration-and-the-hip-committee-of-the-aga
#5
Stefan Fickert, Matthias Aurich, Dirk Albrecht, Peter Angele, Lorenz Büchler, Michael Dienst, Christoph Erggelet, Jürgen Fritz, Christoph Gebhart, Hans Gollwitzer, Moritz Kindler, Christoph Lampert, Henning Madry, Gregor Möckel, Phillip Niemeyer, Jörg Schröder, Christian Sobau, Gunter Spahn, Wolfgang Zinser, Stefan Landgraeber
Background Symptomatic pre-arthritic deformities such as femoroacetabular impingement (FAI) or hip dysplasia often lead to localised cartilage defects and subsequently to osteoarthritis. The present review of the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU) and the hip committee of the AGA (German speaking Society for Arthroscopy and Joint Surgery) provides an overview of current knowledge of the diagnosis and surgical treatment of cartilage defects, in order to infer appropriate therapy recommendations for the hip...
September 15, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28912337/adrenal-hyperandrogenism-does-not-deteriorate-insulin-resistance-and-lipid-profile-in-women-with-pcos
#6
Stavroula A Paschou, Eleni Palioura, Dimitrios Ioannidis, Panagiotis Anagnostis, Argyro Panagiotakou, Vasiliki Loi, Georgios Karageorgos, Dimitrios Goulis, Andromachi Vryonidou
OBJECTIVE: The aim of this study was to investigate the impact of adrenal hyperandrogenism on insulin resistance and lipid profile in women with PCOS. PATIENTS AND METHODS: We studied 372 women with PCOS according to the NIH criteria. 232 age and BMI-matched women served as controls in order to define adrenal hyperandrogenism (DHEA-S >95th percentile). Then, patients with PCOS were classified into two groups, with adrenal hyperandrogenism (PCOS-AH, n=108) and without adrenal hyperandrogenism (PCOS-NAH, n=264)...
September 14, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28911542/classification-and-regulatory-perspectives-of-dietary-fiber
#7
REVIEW
Fan-Jhen Dai, Chi-Fai Chau
This review discusses the history and evolution of the state of dietary fiber (DF) with account of refinements in extraction methods and legal definitions subsequent to the launch of DF hypothesis. For a long time, defining and regulating DFs relied heavily on their chemical compositions and analytical methods. Although chemical compositions and analytical methods still play an important role in the definition of DF, physiological activity has also been taken into consideration. The precise definition of DF is still evolving, particularly whether oligosaccharides degrees of polymerization (DP) 3-9 should be considered as DF or not...
January 2017: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28903398/new-perspectives-of-cobalt-tris-bipyridine-system-anti-cancer-effect-and-its-collateral-sensitivity-towards-multidrug-resistant-mdr-cancers
#8
Betty Yuen Kwan Law, Yuan Qing Qu, Simon Wing Fai Mok, Hauwei Liu, Wu Zeng, Yu Han, Flora Gordillo-Martinez, Wai-Kit Chan, Keith Man-Chung Wong, Vincent Kam Wai Wong
Platinating compounds including cisplatin, carboplatin, and oxaliplatin are common chemotherapeutic agents, however, patients developed resistance to these clinical agents after initial therapeutic treatments. Therefore, different approaches have been applied to identify novel therapeutic agents, molecular mechanisms, and targets for overcoming drug resistance. In this study, we have identified a panel of cobalt complexes that were able to specifically induce collateral sensitivity in taxol-resistant and p53-deficient cancer cells...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902161/biological-evaluation-of-flexible-polyurethane-poly-l-lactic-acid-composite-scaffold-as-a-potential-filler-for-bone-regeneration
#9
Yuk Fai Lui, Wing Yuk Ip
Degradable bone graft substitute for large-volume bone defects is a continuously developing field in orthopedics. With the advance in biomaterial in past decades, a wide range of new materials has been investigated for their potential in this application. When compared to common biopolymers within the field such as PLA or PCL, elastomers such as polyurethane offer some unique advantages in terms of flexibility. In cases of bone defect treatments, a flexible soft filler can help to establish an intimate contact with surrounding bones to provide a stable bone-material interface for cell proliferation and ingrowth of tissue...
September 13, 2017: Materials
https://www.readbyqxmd.com/read/28900574/a-four-phase-physical-therapy-regimen-for-returning-athletes-to-sport-following-hip-arthroscopy-for-femoroacetabular-impingement-with-routine-capsular-closure
#10
Benjamin D Kuhns, Alexander E Weber, Brian Batko, Shane J Nho, Catherine Stegemann
Hip preservation surgery has become more common over the past decade and is now a preferred treatment modality for an increasingly diverse array of pathology in the young, active patient with hip pain. In particular, hip arthroscopy has become an increasingly popular treatment choice for active patients diagnosed with femoroacetabular impingement (FAI). Appropriate postoperative rehabilitation is critical for overall patient success and optimal long-term outcome. As surgical techniques continue to evolve, rehabilitation protocols must adapt to accommodate changes in the surgical procedure and ultimately provide the safest and fastest recovery of function for the patient...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28892856/leachate-breakthrough-mechanism-and-key-pollutant-indicator-of-municipal-solid-waste-landfill-barrier-systems-centrifuge-and-numerical-modeling-approach
#11
Shi Shu, Wei Zhu, Shengwei Wang, Charles Wang Wai Ng, Yunmin Chen, Abraham Chung Fai Chiu
Groundwater pollution by leachate leakage is one of the most common environmental hazards associated with municipal solid waste (MSW) landfill sites. However, landfill leachate contains a large variety of pollutants with widely different concentrations and biotoxicity. Thus, selecting leachate pollutant indicators and levels for identifying breakthrough of barrier systems are key factors in assessing their breakthrough times. This study investigated the transport behavior of leachate pollutants through landfill barrier systems using centrifuge tests and numerical modeling...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28892214/parental-decisions-following-prenatal-diagnosis-of-sex-chromosome-aneuploidy-in-hong-kong
#12
Po Lam So, Kwun Yue Yvonne Cheng, Kwan Yiu Cheuk, Wan Kam Chiu, Shui Lam Mak, Sau Lan Mok, Tsz Kin Lo, Wai Kuen Yung, Fai Man Lo, Hon Yin Brian Chung, Sik Yau Anita Kan, Chin Peng Lee, Hoi Yin Mary Tang
AIM: According to the published work, pregnancy termination rates due to prenatal diagnosis of fetal sex chromosome aneuploidies (SCA) vary widely. Some potentially modifiable and non-modifiable factors have been reported to be associated with parental decision. This study aimed to evaluate the rate of pregnancy termination for fetal SCA and the factors influencing parents' decisions in Hong Kong. METHODS: This was a 21-year retrospective cohort study of parents' decisions following prenatal diagnosis of SCA...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28891140/other-helicobacters-gastric-and-gut-microbiota
#13
REVIEW
Christelle Péré-Védrenne, Bram Flahou, Mun Fai Loke, Armelle Ménard, Jamuna Vadivelu
The current article is a review of the most important and relevant literature published in 2016 and early 2017 on non-Helicobacter pylori Helicobacter infections in humans and animals, as well as interactions between H. pylori and the microbiota of the stomach and other organs. Some putative new Helicobacter species were identified in sea otters, wild boars, dogs, and mice. Many cases of Helicobacter fennelliae and Helicobacter cinaedi infection have been reported in humans, mostly in immunocompromised patients...
September 2017: Helicobacter
https://www.readbyqxmd.com/read/28886532/chemical-characterization-and-sources-of-personal-exposure-to-fine-particulate-matter-pm2-5-in-the-megacity-of-guangzhou-china
#14
Xiao-Cui Chen, Heiko J Jahn, Guenter Engling, Tony J Ward, Alexander Kraemer, Kin-Fai Ho, S H L Yim, Chuen-Yu Chan
Concurrent ambient and personal measurements of fine particulate matter (PM2.5) were conducted in eight districts of Guangzhou during the winter of 2011. Personal-to-ambient (P-C) relationships of PM2.5 chemical components were determined and sources of personal PM2.5 exposures were evaluated using principal component analysis and a mixed-effects model. Water-soluble inorganic ions (e.g., SO4(2-), NO3(-), NH4(+), C2O4(2-)) and anhydrosugars (e.g., levoglucosan, mannosan) exhibited median personal-to-ambient (P/C) ratios < 1 accompanied by strong P-C correlations, indicating that these constituents in personal PM2...
September 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28884877/self-administered-acupressure-for-insomnia-disorder-a-pilot-randomized-controlled-trial
#15
Wing-Fai Yeung, Fiona Yan-Yee Ho, Ka-Fai Chung, Zhang-Jin Zhang, Branda Yee-Man Yu, Lorna Kwai-Ping Suen, Lily Ying-Tung Chan, Hai-Yong Chen, Lai-Ming Ho, Li-Xing Lao
Self-administered acupressure has potential as a low-cost alternative treatment for insomnia. To evaluate the short-term effects of self-administered acupressure for alleviating insomnia, a pilot randomized controlled trial was conducted. Thirty-one subjects (mean age: 53.2 years; 77.4% female) with insomnia disorder were recruited from a community. The participants were randomized to receive two lessons on either self-administered acupressure or sleep hygiene education. The subjects in the self-administered acupressure group (n = 15) were taught to practise self-administered acupressure daily for 4 weeks...
September 8, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28879042/salivary-gland-ultrasound-abnormalities-in-primary-sj%C3%A3-gren-s-syndrome-consensual-us-sg-core-items-definition-and-reliability
#16
Sandrine Jousse-Joulin, Emmanuel Nowak, Divi Cornec, Jackie Brown, Andrew Carr, Marina Carotti, Benjamin Fisher, Joel Fradin, Alojzija Hocevar, Malin V Jonsson, Nicoletta Luciano, Vera Milic, John Rout, Elke Theander, Aaltje Stel, Hendrika Bootsma, Arjan Vissink, Chiara Baldini, Alan Baer, Wan Fai Ng, Simon Bowman, Zarrin Alavi, Alain Saraux, Valérie Devauchelle-Pensec
OBJECTIVES: Ultrasonography (US) is sensitive for detecting echostructural abnormalities of the major salivary glands (SGs) in primary Sjögren's syndrome (pSS). Our objectives were to define selected US-SG echostructural abnormalities in pSS, set up a preliminary atlas of these definitions and evaluate the consensual definitions reliability in both static and acquisition US-SG images. METHODS: International experts in SG US in pSS participated in consensus meetings to select and define echostructural abnormalities in pSS...
2017: RMD Open
https://www.readbyqxmd.com/read/28878137/cf-airway-smooth-muscle-transcriptome-reveals-a-role-for-pyk2
#17
Daniel P Cook, Ryan J Adam, Keyan Zarei, Benjamin Deonovic, Mallory R Stroik, Nicholas D Gansemer, David K Meyerholz, Kin Fai Au, David A Stoltz
Abnormal airway smooth muscle function can contribute to cystic fibrosis (CF) airway disease. We previously found that airway smooth muscle from newborn CF pigs had increased basal tone, an increased bronchodilator response, and abnormal calcium handling. Since CF pigs lack airway infection and inflammation at birth, these findings suggest intrinsic airway smooth muscle dysfunction in CF. In this study, we tested the hypothesis that CFTR loss in airway smooth muscle would produce a distinct set of changes in the airway smooth muscle transcriptome that we could use to develop novel therapeutic targets...
September 7, 2017: JCI Insight
https://www.readbyqxmd.com/read/28869708/optimization-of-spark-plasma-sintered-titania-for-potential-application-as-a-keratoprosthesis-skirt
#18
Zhong Li, Gary Hin-Fai Yam, Brianna C Thompson, Melina Setiawan, Gwendoline Tze Wei Goh, Donald Tan, Jodhbir S Mehta, Khiam Aik Khor
The manufacture of mechanically strong and biocompatible titania (TiO2 ) materials is of vital importance for their application as corneal implant skirts. This study was aimed at optimizing the selection of raw powder and sintering conditions for TiO2 ceramics. TiO2 compacts were synthesized from five raw powders, denoted as Altair, Inframat, Alfa, Materion and Amperit, respectively, by spark plasma sintering using different sintering parameters. The XRD and Raman results confirmed that the anatase TiO2 phase in the Inframat powder had converted completely to rutile TiO2 phase after sintering at 900°C and above...
September 4, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28868742/a-life-threatening-transfusion-reaction
#19
Wai Shan Wong, Kit Fai Wong, Janette Kwok, Wai Chiu Tsoi, Jennifer Ngar-Sze Leung
No abstract text is available yet for this article.
September 2017: Transfusion
https://www.readbyqxmd.com/read/28868322/viability-and-tissue-quality-of-cartilage-flaps-from-patients-with-femoroacetabular-hip-impingement-a-matched-control-comparison
#20
Francisco Rodriguez-Fontan, Karin A Payne, Jorge Chahla, Omer Mei-Dan, Abigail Richards, Soshi Uchida, Cecilia Pascual-Garrido
BACKGROUND: Chondrolabral damage is commonly observed in patients with cam-type femoroacetabular impingement (FAI). Chondral flap reattachment has recently been proposed as a possible preservation technique. PURPOSE/HYPOTHESIS: The purpose of this study was to determine the viability and tissue quality of chondral flaps from patients with FAI at the time of arthroscopy. It was hypothesized that chondral flaps from patients with cam lesions of the hip would exhibit less viability and greater tissue degeneration than would those of a matched control group...
August 2017: Orthopaedic Journal of Sports Medicine
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