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https://www.readbyqxmd.com/read/28806671/characterization-and-health-risk-assessment-of-pm2-5-bound-organics-inside-and-outside-of-chinese-smoking-lounges
#1
Lijuan Li, Steven Sai Hang Ho, Judith C Chow, John G Watson, Frank S C Lee, Long Cui, Yuan Gao, Wenting Dai, Kin Fai Ho, Yu Huang, Junji Cao
PM2.5 samples were collected at six indoor public places that contained dedicated smoking lounges. Samples were taken in the smoking lounges, at two indoor locations outside of the lounges, and in outdoor air near the venues. Organic carbon (OC), elemental carbon (EC), and non-polar organic compounds including polycyclic aromatic hydrocarbons (PAHs), n-alkanes (n-C16 to n-C40), iso/anteiso-alkanes (C29 to C33), hopanes and phthalate esters (PAEs) were quantified. Average PM2.5 levels of 170.2 ± 85.9 μg/m(3) in the lounges exceeded limits of 25 μg/m(3) set by World Health Organization (WHO); these levels were 5...
August 4, 2017: Chemosphere
https://www.readbyqxmd.com/read/28803685/quantification-of-pulmonary-regurgitation-by-vector-flow-mapping-in-congenital-heart-patients-after-repair-of-right-ventricular-outflow-obstruction-a-preliminary-study
#2
Ashley Hoi-Man To, Vivian Wing-Yi Li, Ming-Yen Ng, Yiu-Fai Cheung
BACKGROUND: Vector flow mapping (VFM) enables direct visualization of flow pattern and estimation of flow volume. The aim of this study was to determine its accuracy in the quantification of pulmonary regurgitation (PR) in congenital heart patients after repair of right ventricular (RV) outflow obstruction. METHODS: This study comprised two parts: (1) validation of VFM in the quantification of PR in patients with repaired tetralogy of Fallot by cardiac magnetic resonance and (2) clinical application of VFM to determine PR in patients after biventricular repair of pulmonary atresia and stenosis with intact ventricular septum...
August 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28803458/neglect-and-aphasia-in-the-acute-phase-as-predictors-of-functional-outcome-seven-years-after-ischemic-stroke
#3
Joel Gerafi, Hans Samuelsson, Jo I Viken, Charlotte Blomgren, Lisbeth Claesson, Sakari Kallio, Christina Jern, Christian Blomstrand, Katarina Jood
BACKGROUND: Visuospatial inattention (VSI) and language impairment (LI) are often present early after stroke and associations with an unfavorable short-term functional outcome have been reported. The purpose of this study was to investigate if a screening of VSI and of LI as indicators of cortical symptoms early after stroke could predict long-term functional outcomes. METHODS: A consecutive cohort of 375 ischemic stroke patients was assessed for the occurrence of VSI, in median, 7 days after admission (interquartile range 5 days) using Star Cancellation Test (SCT) and for LI (within the first 7 days) with the language item in the Scandinavian Stroke Scale (SSS)...
August 12, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28799961/nurses-perceptions-of-psychosocial-care-and-barriers-to-its-provision-a-qualitative-study
#4
Cassandra Siyun Chen, Sally Wai-Chi Chan, Moon Fai Chan, Suk Foon Yap, Wenru Wang, Yanika Kowitlawakul
BACKGROUND: Psychosocial care is the culturally sensitive provision of psychological, social, and spiritual care through therapeutic communication. Current evidence suggests that effective psychosocial care improves patients' health outcomes and quality of life. PURPOSE: The aim of this study was to explore nurses' perceptions and experiences in providing psychosocial care to patients and to identify the related barriers and challenges. METHODS: An exploratory qualitative design using semistructured, individual, face-to-face interviews was adopted...
August 10, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28795076/intraoperative-radiation-exposure-during-hip-arthroscopy
#5
John P Salvo, Jake Zarah, Zaira S Chaudhry, Kirsten L Poehling-Monaghan
BACKGROUND: The frequency of hip arthroscopy for the treatment of acute and chronic chondrolabral pathology and femoroacetabular impingement (FAI) has increased exponentially over the past decade. While surgeon and patient radiation exposure has been well documented in other areas of the orthopaedic literature, little is known about the procedure-specific and cumulative doses affecting the hip arthroscopist. PURPOSE: To determine the mean annual radiation exposure to the hip arthroscopist and the mean surgeon exposure per case...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28792880/analysis-of-plasma-epstein-barr-virus-dna-to-screen-for-nasopharyngeal-cancer
#6
K C Allen Chan, John K S Woo, Ann King, Benny C Y Zee, W K Jacky Lam, Stephen L Chan, Sam W I Chu, Constance Mak, Irene O L Tse, Samantha Y M Leung, Gloria Chan, Edwin P Hui, Brigette B Y Ma, Rossa W K Chiu, Sing-Fai Leung, Andrew C van Hasselt, Anthony T C Chan, Y M Dennis Lo
BACKGROUND: Circulating cell-free Epstein-Barr virus (EBV) DNA is a biomarker for nasopharyngeal carcinoma. We conducted a prospective study to investigate whether EBV DNA in plasma samples would be useful to screen for early nasopharyngeal carcinoma in asymptomatic persons. METHODS: We analyzed EBV DNA in plasma specimens to screen participants who did not have symptoms of nasopharyngeal carcinoma. Participants with initially positive results were retested approximately 4 weeks later, and those with persistently positive EBV DNA in plasma underwent nasal endoscopic examination and magnetic resonance imaging (MRI)...
August 10, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28791440/therapeutic-potentials-of-short-interfering-rnas
#7
REVIEW
Chit Tam, Jack Ho Wong, Randy Chi Fai Cheung, Tao Zuo, Tzi Bun Ng
Short interfering RNA (siRNA) is one of the members of the family of RNA interference (RNAi). Coupled with the RNA-induced silencing complex (RISC), siRNA is able to trigger the cleavage of target RNAs which serve as a defensive system against pathogens. Meanwhile, siRNA in gene silencing opens a new avenue for the treatment of various diseases. SiRNA can effectively inhibit viral infection and replication and suppress tumorigenesis and various inflammation-associated diseases and cardiovascular diseases by inactivation of viral genes and downregulation of oncogene expression...
August 8, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28790036/surgical-treatment-of-femoroacetabular-impingement-following-slipped-capital-femoral-epiphysis-a-systematic-review
#8
K O Oduwole, D de Sa, J Kay, F Findakli, A Duong, N Simunovic, Y Yi-Meng, O R Ayeni
OBJECTIVES: The purpose of this study was to evaluate the existing literature from 2005 to 2016 reporting on the efficacy of surgical management of patients with femoroacetabular impingement (FAI) secondary to slipped capital femoral epiphysis (SCFE). METHODS: The electronic databases MEDLINE, EMBASE, and PubMed were searched and screened in duplicate. Data such as patient demographics, surgical technique, surgical outcomes and complications were retrieved from eligible studies...
August 2017: Bone & Joint Research
https://www.readbyqxmd.com/read/28783084/enter-the-dragon-the-dynamic-and-multifunctional-evolution-of-anguimorpha-lizard-venoms
#9
Ivan Koludarov, Timothy Nw Jackson, Bianca Op den Brouw, James Dobson, Daniel Dashevsky, Kevin Arbuckle, Christofer J Clemente, Edward J Stockdale, Chip Cochran, Jordan Debono, Carson Stephens, Nadya Panagides, Bin Li, Mary-Louise Roy Manchadi, Aude Violette, Rudy Fourmy, Iwan Hendrikx, Amanda Nouwens, Judith Clements, Paolo Martelli, Hang Fai Kwok, Bryan G Fry
While snake venoms have been the subject of intense study, comparatively little work has been done on lizard venoms. In this study, we have examined the structural and functional diversification of anguimorph lizard venoms and associated toxins, and related these results to dentition and predatory ecology. Venom composition was shown to be highly variable across the 20 species of Heloderma, Lanthanotus, and Varanus included in our study. While kallikrein enzymes were ubiquitous, they were also a particularly multifunctional toxin type, with differential activities on enzyme substrates and also ability to degrade alpha or beta chains of fibrinogen that reflects structural variability...
August 6, 2017: Toxins
https://www.readbyqxmd.com/read/28781156/evaluation-of-deformed-image-based-dose-calculations-for-adaptive-radiotherapy-of-nasopharyngeal-carcinoma
#10
Miranda Poon, Catherine Holborn, Ka Fai Cheng, Winky Wing Ki Fung, George Chiu
The ultimate goal of adaptive radiotherapy (ART) is to deliver truly customized radiation treatments. Currently, the quality of cone-beam computed tomography (CBCT) images is still inferior to that of conventional CT images in contour delineations and dose calculations for replanning purposes. This retrospective study aims to evaluate the dosimetric accuracy of using deformed conventional CT images for dose calculations, in the hope of inferring the feasibility of ART using planning CT (PCT) images that deformed to up-to-date CBCT images for patients with nasopharyngeal carcinoma (NPC)...
August 3, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28778002/the-efficacy-of-combined-educational-and-site-management-actions-in-reducing-off-trail-hiking-in-an-urban-proximate-protected-area
#11
Karen S Hockett, Jeffrey L Marion, Yu-Fai Leung
Park and protected area managers are tasked with protecting natural environments, a particularly daunting challenge in heavily visited urban-proximate areas where flora and fauna are already stressed by external threats. In this study, an adaptive management approach was taken to reduce extensive off-trail hiking along a popular trail through an ecologically diverse and significant area in the Chesapeake and Ohio National Historical Park near Washington DC. Substantial amounts of off-trail hiking there had created an extensive 16...
August 1, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28776327/helicobacter-pylori-outer-inflammatory-protein-a-oipa-suppresses-apoptosis-of-ags-gastric-cells-in-vitro
#12
Anis Rageh Al-Maleki, Mun Fai Loke, Sook Yin Lui, Nur Siti Khadijah Ramli, Yalda Khosravi, Chow Goon Ng, Gopinath Venkatraman, Khean-Lee Goh, Bow Ho, Jamuna Vadivelu
Outer Inflammatory Protein A (OipA) is an important virulence factor associated with gastric cancer and ulcer development, however the results has not been well-established and turned out to be controversial. This study aims to elucidate the role of OipA in H. pylori infection using clinical strains harboring oipA "on" and "off" motifs. Proteomics analysis was performed on AGS cell pre and post-infection with H. pylori oipA "on" and "off" strains, using liquid chromatography / mass spectrometry. AGS apoptosis and cell cycle assays were performed...
August 3, 2017: Cellular Microbiology
https://www.readbyqxmd.com/read/28766911/from-fenestrindane-toward-saddle-shaped-nanographenes-bearing-a-tetracoordinate-carbon-atom
#13
Wai-Shing Wong, Chun-Fai Ng, Dietmar Kuck, Hak-Fun Chow
Two saddle-shaped polycyclic aromatic compounds 8a and 8b bearing an all-cis-[5.5.5.5]fenestrane core surrounded by an o,p,o,p,o,p,o,p-cyclooctaphenylene belt were synthesized and characterized by NMR spectroscopy and mass spectrometry. The key step featured four Scholl-type cycloheptatriene formation steps of the corresponding 1,4,9,12-tetraarylfenestrindane derivatives 7a and 7b bearing electron-rich substituents. The structural details of the D2d-symmetrical saddle 8a were determined by X-ray crystallography, and the photoelectronic and cyclovoltammetric properties of 8a and 8b were studied...
August 1, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28765577/cacna1c-polymorphisms-impact-cognitive-recovery-in-patients-with-bipolar-disorder-in-a-six-week-open-label-trial
#14
Kangguang Lin, Guiyun Xu, Lingling Shi, Weicong Lu, Lijie Guan, Huiyi Ouyang, Kun Chen, Yamei Dang, Libing Zhou, Kwok-Fai So
Cognitive impairments in bipolar patients deteriorate as the disorder progresses. Little is known about whether genetic risks impact cognitive recovery during the course from depression to remission. In this six-week open-label trial, we shed light on the impacts of six single nucleotide polymorphisms (SNPs) in the calcium voltage-gated channel subunit alpha1 C (CACNA1C) gene on cognitive recovery in 192 bipolar patients suffering a major depressive episode (MDE). The primary outcome measures were changes in a battery of neuropsychological tests following 6-week treatment...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28764641/prediction-of-new-onset-of-end-stage-renal-disease-in-chinese-patients-with-type-2-diabetes-mellitus-a-population-based-retrospective-cohort-study
#15
Eric Yuk Fai Wan, Daniel Yee Tak Fong, Colman Siu Cheung Fung, Esther Yee Tak Yu, Weng Yee Chin, Anca Ka Chun Chan, Cindy Lo Kuen Lam
BACKGROUND: Since diabetes mellitus (DM) is the leading cause of end stage renal disease (ESRD), this study aimed to develop a 5-year ESRD risk prediction model among Chinese patients with Type 2 DM (T2DM) in primary care. METHODS: A retrospective cohort study was conducted on 149,333 Chinese adult T2DM primary care patients without ESRD in 2010. Using the derivation cohort over a median of 5 years follow-up, the gender-specific models including the interaction effect between predictors and age were derived using Cox regression with a forward stepwise approach...
August 1, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28762536/a-novel-mr-based-method-for-detection-of-cartilage-delamination-in-femoroacetabular-impingement-patients
#16
Michael A Samaan, Valentina Pedoia, Alan L Zhang, Matthew C Gallo, Thomas M Link, Richard B Souza, Sharmila Majumdar
In this study, quantitative magnetic resonance based measurements were used to evaluate T1ρ and T2 mapping and heterogeneity in femoroacetabular impingement (FAI) patients with acetabular cartilage delamination and to determine the ability of these quantitative MR-based measurements in detecting delamination. Unilateral hip joint MR-scans of 36 FAI patients with arthroscopically-confirmed acetabular cartilage delamination and 36 age, gender and BMI matched controls were obtained. T1ρ and T2 mapping and heterogeneity of the hip joint articular cartilage were assessed in both groups using voxel-based relaxometry (VBR)...
August 1, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28761656/androstenedione-and-testosterone-levels-correlate-with-in-vitro-fertilization-rates-in-insulin-resistant-women
#17
Thozhukat Sathyapalan, Emily H Dickerson, Stephen M Maguiness, John Robinson, Youssra H Z Dakroury, Stephen L Atkin
BACKGROUND: The free androgen index (FAI) calculated using total testosterone measured by immunoassay does not correlate with oocyte fertilization rates; however, there is considerable cross-reactivity for testosterone with other androgens by immunoassay that is not found using isotope dilution liquid chromatography-tandem mass spectrometry (LC/MS/MS). AIMS: This study was done to determine relationship between total testosterone and androstenedione measured by LC/MS/MS and fertilization rates...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/28759182/intima-media-thickness-of-common-carotids-and-abdominal-aorta-in-children-and-adolescents-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency-in-relation-to-their-genotypes
#18
Dominika Janus, Malgorzata Wojcik, Katarzyna Tyrawa, Magdalena Janeczko, Mirosław Bik-Multanowski, Jerzy B Starzyk
BACKGROUND: Patients with congenital adrenal hyperplasia (CAH) are at risk of vascular and metabolic complications due to steroid therapy and increased adrenal androgens exposure. OBJECTIVE: of the study was to evaluate the relation between patient's genotype and (1) intima media thickness of abdominal aorta (AIMT) and common carotid arteries (CIMT) and (2) metabolic profile. MATERIAL AND METHODS: In 71 patients (27 boys) aged from 1.5 to 17...
July 2, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28749602/clinical-pattern-and-prevalence-of-upper-gastrointestinal-toxicity-in-ketamine-abusers
#19
Shirley Yuk Wah Liu, Stephen Ka Kei Ng, Yuk Him Tam, Samuel Chi Hang Yee, Franco Pui Tak Lai, Cindy Yuek Lam Hong, Philip Wai Yan Chiu, Enders Kwok Wai Ng, Chi Fai Ng
AIM: While evidence about ketamine-related urological and hepatobiliary injuries was emerging, evaluation about upper gastrointestinal toxicity from ketamine abuse was uncommon. This study aims to investigate the clinical pattern and prevalence of upper gastrointestinal symptoms in inhalational ketamine abusers. METHODS: This was a cross sectional study of 611 consecutive ketamine abusers who were seeking treatment for ketamine uropathy in a tertiary hospital setting between August 2008 and June 2016...
July 27, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28744938/integrative-body-mind-spirit-intervention-for-concurrent-sleep-and-mood-disturbances-sleep-specific-daytime-functioning-mediates-sleep-and-mood-improvements
#20
Xiao-Wen Ji, Siu-Man Ng, Cecilia L W Chan, Jessie S M Chan, Celia H Y Chan, Ka-Fai Chung
Sleep disturbances and depressive symptoms are associated closely with daytime dysfunctions, yet few studies have investigated their temporal relationship in a randomized controlled trial. We investigated the inter-relationships among sleep, depressive symptoms and daytime functioning following an integrative body-mind-spirit (I-BMS) intervention. One hundred and eighty-five participants (mean age 55.28 years, 75.1% female) with co-existing sleep and depressive symptoms were randomized to I-BMS or waiting-list...
July 26, 2017: Journal of Sleep Research
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