keyword
MENU ▼
Read by QxMD icon Read
search

Fai

keyword
https://www.readbyqxmd.com/read/29353015/proteomic-and-functional-variation-within-black-snake-venoms-elapidae-pseudechis
#1
Jonathan Goldenberg, Vittoria Cipriani, Timothy N W Jackson, Kevin Arbuckle, Jordan Debono, Daniel Dashevsky, Nadya Panagides, Maria P Ikonomopoulou, Ivan Koludarov, Bin Li, Renan Castro Santana, Amanda Nouwens, Alun Jones, Chris Hay, Nathan Dunstan, Luke Allen, Brian Bush, John J Miles, Lilin Ge, Hang Fai Kwok, Bryan G Fry
Pseudechis (black snakes) is an Australasian elapid snake genus that inhabits much of mainland Australia, with two representatives confined to Papua New Guinea. The present study is the first to analyse the venom of all 9 described Pseudechis species (plus one undescribed species) to investigate the evolution of venom composition and functional activity. Proteomic results demonstrated that the typical Pseudechis venom profile is dominated by phospholipase A2 toxins. Strong cytotoxicity was the dominant function for most species...
January 15, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29352659/microwave-ablation-provides-better-survival-than-liver-resection-for-hepatocellular-carcinoma-in-patients-with-borderline-liver-function-application-of-albi-score-to-patient-selection
#2
Charing C N Chong, Kit-Fai Lee, Cheuk-Man Chu, Anthony W H Chan, John Wong, Stephen L Chan, Hon-Ting Lok, Andrew K Y Fung, Anthony K W Fong, Yue S Cheung, Simon C H Yu, Philip Johnson, Paul B S Lai
BACKGROUND: Studies comparing microwave ablation (MWA) and liver resection are lacking. This study evaluates the survival of patients with hepatocellular carcinoma (HCC) treated with liver resection or MWA and the role of Albumin-Bilirubin (ALBI) score in patient selection for treatments. METHODS: This is a retrospective analysis of patients who received curative liver resection or MWA for HCC. Propensity score matching was used at a 1:1 ratio. The value of ALBI grade for patient selection was evaluated...
January 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29348484/activation-of-ca2-sensing-receptor-as-a-protective-pathway-to-reduce-cadmium-induced-cytotoxicity-in-renal-proximal-tubular-cells
#3
Jie Gu, Shuya Dai, Yanmin Liu, Haitao Liu, Yao Zhang, Xingqi Ji, Feng Yu, Yang Zhou, Liang Chen, William Ka Fai Tse, Chris Kong Chu Wong, Binghai Chen, Haifeng Shi
Cadmium (Cd), as an extremely toxic metal could accumulate in kidney and induce renal injury. Previous studies have proved that Cd impact on renal cell proliferation, autophagy and apoptosis, but the detoxification drugs and the functional mechanism are still in study. In this study, we used mouse renal tubular epithelial cells (mRTECs) to clarify Cd-induced toxicity and signaling pathways. Moreover, we proposed to elucidate the prevent effect of activation of Ca2+ sensing receptor (CaSR) by Calcimimetic (R-467) on Cd-induced cytotoxicity and underlying mechanisms...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29347740/evolving-power-grids-with-self-organized-intermittent-strain-releases-an-analogy-with-sandpile-models-and-earthquakes
#4
Ho Fai Po, Chi Ho Yeung, An Zeng, K Y Michael Wong
The stability of powergrid is crucial since its disruption affects systems ranging from street lightings to hospital life-support systems. While short-term dynamics of single-event cascading failures have been extensively studied, less is understood on the long-term evolution and self-organization of powergrids. In this paper, we introduce a simple model of evolving powergrid and establish its connection with the sandpile model and earthquakes, i.e., self-organized systems with intermittent strain releases...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29342058/mri-evaluation-of-repaired-versus-unrepaired-interportal-capsulotomy-in-simultaneous-bilateral-hip-arthroscopy-a-double-blind-randomized-controlled-trial
#5
Colin D Strickland, Matthew J Kraeutler, Matthew J Brick, Tigran Garabekyan, Jason T K Woon, Vivek Chadayammuri, Omer Mei-Dan
BACKGROUND: Techniques used in hip arthroscopy continue to evolve, and controversy surrounds the need for capsular repair following this surgical intervention. The purpose of this study was to evaluate the magnetic resonance imaging (MRI) appearance of the hip capsule in patients with femoroacetabular impingement (FAI) who underwent simultaneous bilateral hip arthroscopy through an interportal capsulotomy with each hip randomized to undergo capsular repair or not undergo such a repair...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29340880/gata-3-is-superior-to-gcdfp-15-and-mammaglobin-to-identify-primary-and-metastatic-breast-cancer
#6
Yun-Bi Ni, Julia Y S Tsang, Mu-Min Shao, Siu-Ki Chan, Sai-Yin Cheung, Joanna Tong, Ka-Fai To, Gary M Tse
PURPOSE: Despite numerous studies on the utility of GATA-3 as breast cancer marker, its comparison with other breast markers, its concordance between primary and metastatic tumors and its expression in primary cancers from sites with frequent breast metastases remains unclear. METHODS: To address these questions, totally 993 invasive breast cancers (IBC), 254 paired nodal metastases, 23 distant metastases, and 208 lung carcinomas were included. GATA-3 expression was analyzed by immunohistochemistry and compared to other breast markers [gross cystic disease fluid protein 15 (GCDFP-15) and mammaglobin (MGB)]...
January 16, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29338553/comprehensive-clinicopathologic-and-updated-immunohistochemical-characterization-of-primary-ovarian-mucinous-carcinoma
#7
Dina Bassiouny, Nadia Ismiil, Valerie Dubé, Guangming Han, Matthew Cesari, Fang-I Lu, Elzbieta Slodkowska, Carlos Parra-Herran, Hak Fai Chiu, Magda Naeim, Nim Li, Mahmoud Khalifa, Sharon Nofech-Mozes
The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11...
January 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29338126/physical-exercise-and-glaucoma-a-review-on-the-roles-of-physical-exercise-on-intraocular-pressure-control-ocular-blood-flow-regulation-neuroprotection-and-glaucoma-related-mental-health
#8
REVIEW
Ming Ming Zhu, Jimmy Shiu Ming Lai, Bonnie Nga Kwan Choy, Jennifer Wei Huen Shum, Amy Cheuk Yin Lo, Alex Lap Ki Ng, Jonathan Cheuk Hung Chan, Kwok Fai So
The benefits of physical exercise on health and well-being have been studied in a wide range of systemic and ocular diseases, including glaucoma, a progressive optic neuropathy characterized by accelerated apoptosis of retinal ganglion cells (RGCs). Elevated intraocular pressure (IOP) and insufficient ocular perfusion have been postulated to be the two main theories in glaucoma development and progression. The effects of exercise in these two aspects have been demonstrated by numerous researches. A review in 2009 focusing on these two theories concluded that exercise results in transient IOP reduction but an inconsistent elevation in ocular perfusion...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29336886/can-the-syndesmosis-procedure-prevent-metatarsus-primus-varus-and-hallux-valgus-deformity-recurrence-a-5-year-prospective-study
#9
Daniel Yiang Wu, Eddy Kwok Fai Lam
One of the main objectives of hallux valgus surgery is correction of the metatarsus primus varus deformity by osteotomy, arthrodesis, or soft tissue correction. The syndesmosis procedure uses intermetatarsal cerclage sutures to realign the first metatarsal and also induces a syndesmotic bonding between the first and second metatarsals to prevent metatarsus primus varus deformity recurrence. The purpose of the present study was to demonstrate radiologic evidence of the effectiveness of the syndesmosis concept and to identify the incidence and nature of deformity recurrence...
January 12, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29331931/resting-state-fmri-signals-in-offspring-of-parents-with-bipolar-disorder-at-the-high-risk-and-ultra-high-risk-stages-and-their-relations-with-cognitive-function
#10
Kangguang Lin, Robin Shao, Rui Lu, Kun Chen, Weicong Lu, Ting Li, Jiehua Kong, Kwok-Fai So, Guiyun Xu
BACKGROUND: Bipolar disorder (BD) has been associated with dysfunctional resting-state brain functioning. However, it is still not known whether the aberrant functioning occurs and predict cognitive functioning before illness onset. AIMS: We examined the resting-state regional and network dysfunctioning, and their correlates with neurocognitive performance, in the high-risk (HR) and ultra-high-risk (UHR) stages of bipolar disorder. METHODS: Using amplitude of low-frequency fluctuations (ALFF), region homogeneity (ReHo) and hypothesis-driven region-of-interest (ROI)-based connectivity, we examined resting-state fMRI data of 8- to 25-year-old healthy offspring (HR, n = 28) and offspring with subthreshold syndromes (UHR, n = 22) of a BD parent, and age-matched healthy controls without any personal or family psychopathology (HC, n = 46)...
January 8, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29322276/integrating-direct-observation-and-gps-tracking-to-monitor-animal-behavior-for-resource-management
#11
Chelsey Walden-Schreiner, Yu-Fai Leung, Tim Kuhn, Todd Newburger
Monitoring the behavior of pack animals in protected areas informs management about use patterns and the potential associated negative impacts. However, systematic assessments of behavior are uncommon due to methodological and logistical constraints. This study integrated behavior mapping with GPS tracking, and applied behavior change point analysis, as an approach to monitor the behaviors of pack animals during overnight periods. The integrated approach identified multiple grazing patterns (i.e., locally intense grazing, ambulatory grazing) not feasible through a single methodology alone...
January 10, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29310055/the-effect-of-additional-joint-mobilization-on-neuromuscular-performance-in-individuals-with-functional-ankle-instability
#12
Yi-Fen Shih, Hsiang-Ting Yu, Wen-Yin Chen, Kwong-Kum Liao, Hsiu-Chen Lin, Yea-Ru Yang
OBJECTIVES: To examine the effects of joint mobilization and exercise training on neuromuscular performance in individuals with functional ankle instability (FAI). DESIGN: A cross-sectional study. PARTICIPANTS: Forty five subjects with FAI were randomized into three groups: control (CG, n = 15, 27.9 ± 6.6yr), training (TG, n = 15, 26.9 ± 5.8yr) and mobilization with training group (MTG, n = 15, 26.5 ± 4.8yr). INTERVENTION: Four weeks of neuromuscular training for TG; neuromuscular training and joint mobilization for MTG...
December 20, 2017: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29308498/a-ferroelectric-relaxor-polymer-enhanced-p-type-wse2-transistor
#13
Chong Yin, Xudong Wang, Yan Chen, Dan Li, Tie Lin, Shuo Sun, Hong Shen, Piyi Du, Jinglan Sun, Xiangjian Meng, Junhao Chu, Hon Fai Wong, Chi Wah Leung, Zongrong Wang, Jianlu Wang
WSe2 has attracted extensive attention for p-FETs due to its air stability and high mobility. However, the Fermi level of WSe2 is close to the middle of the band gap, which will induce a high contact resistance with metals and thus limit the field effect mobility. In this case, a high work voltage is always required to achieve a large ON/OFF ratio. Herein, a stable WSe2 p-doping technique of coating using a ferroelectric relaxor polymer P(VDF-TrFE-CFE) is proposed. Unlike other doping methods, P(VDF-TrFE-CFE) not only can modify the Fermi level of WSe2 but can also act as a high-k gate dielectric in an FET...
January 8, 2018: Nanoscale
https://www.readbyqxmd.com/read/29306128/inhibitory-effect-of-self-generated-extracellular-dissolved-organic-carbon-on-carbon-dioxide-fixation-in-sulfur-oxidizing-bacteria-during-a-chemoautotrophic-cultivation-process-and-its-elimination
#14
Ya-Nan Wang, Yiu Fai Tsang, Lei Wang, Xiaohua Fu, Jiajun Hu, Huan Li, Yiquan Le
The features of extracellular dissolved organic carbon (EDOC) generation in two typical aerobic sulfur-oxidizing bacteria (Thiobacillus thioparus DSM 505 and Halothiobacillus neapolitanus DSM 15147) and its impact on CO2 fixation during chemoautotrophic cultivation process were investigated. The results showed that EDOC accumulated in both strains during CO2 fixation process. Large molecular weight (MW) EDOC derived from cell lysis and decay was dominant during the entire process in DSM 505, whereas small MW EDOC accounted for a large proportion during initial and middle stages of DSM 15147 as its cytoskeleton synthesis rate did not keep up with CO2 assimilation rate...
December 29, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29301556/combined-electroacupuncture-and-auricular-acupuncture-for-postoperative-pain-after-abdominal-surgery-for-gynecological-diseases-study-protocol-for-a-randomized-controlled-trial
#15
Wing Lok Lam, Wing Fai Yeung, Mei Kuen Wong, Chi Wai Cheung, Karen Kar Loen Chan, Hextan Yuen Sheung Ngan, Carlos King Ho Wong, Hai Yong Chen, Lixing Lao
BACKGROUND: Postoperative pain is a major complaint following abdominal surgery for gynecological diseases. Effective postoperative pain control after abdominal surgery is particularly important for patient recovery, mobility, and satisfaction. Acupuncture has been commonly used for pain management. However, its efficacy in postoperative pain control is inconclusive and health economic evaluation is limited. METHODS: A randomized, sham-controlled, patient- and- assessor-blind trial is designed to evaluate the efficacy and safety of acupuncture in managing postoperative pain following abdominal surgery of gynecological diseases...
January 4, 2018: Trials
https://www.readbyqxmd.com/read/29299653/arthroscopic-versus-open-treatment-of-cam-type-femoro-acetabular-impingement-retrospective-cohort-clinical-study
#16
Paulo A Rego, Vasco Mascarenhas, Filipe S Oliveira, Pedro C Pinto, Eduardo Sampaio, Jacinto Monteiro
PURPOSE: The purpose of this study was to determine if there were significant differences between patients submitted to hip arthroscopy (HA) and surgical hip dislocation (SHD) to treat femoro-acetabular impingement (FAI), which variables were significantly associated with hip function before surgery and those predictive of the applied functional outcome scale and its variation rate after surgery. METHODS: We selected 198 patients treated with HA or SHD with a mean follow-up of 59 months...
January 3, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29295891/a-peptidylic-inhibitor-for-neutralizing-expanded-cag-rna-induced-nucleolar-stress-in-polyglutamine-diseases
#17
Qian Zhang, Zhefan Stephen Chen, Ying An, Haizhen Liu, Yonghui Hou, Wen Li, Kwok-Fai Lau, Alex Koon, Jacky Ngo, Edwin Chan
Polyglutamine (polyQ) diseases are a set of progressive neurodegenerative disorders ascribed by the expression of both expanded CAG RNA and misfolded polyQ protein. We previously reported that the direct interaction between expanded CAG RNA and nucleolar protein nucleolin (NCL) leads to impediment of pre-ribosomal RNA (pre-rRNA) transcription, and eventually triggers nucleolar stress-induced apoptosis in polyQ diseases. Here, we report a 21-amino acid peptide, named beta-structured inhibitor for neurodegenerative disease (BIND), effectively suppresses expanded CAG RNA toxicity...
January 2, 2018: RNA
https://www.readbyqxmd.com/read/29295495/rethinking-the-combination-of-proton-exchanger-inhibitors-in-cancer-therapy
#18
REVIEW
Elisabetta Iessi, Mariantonia Logozzi, Davide Mizzoni, Rossella Di Raimo, Claudiu T Supuran, Stefano Fais
Microenvironmental acidity is becoming a key target for the new age of cancer treatment. In fact, while cancer is characterized by genetic heterogeneity, extracellular acidity is a common phenotype of almost all cancers. To survive and proliferate under acidic conditions, tumor cells up-regulate proton exchangers and transporters (mainly V-ATPase, Na⁺/H⁺ exchanger (NHE), monocarboxylate transporters (MCTs), and carbonic anhydrases (CAs)), that actively extrude excess protons, avoiding intracellular accumulation of toxic molecules, thus becoming a sort of survival option with many similarities compared with unicellular microorganisms...
December 23, 2017: Metabolites
https://www.readbyqxmd.com/read/29294788/the-impact-of-child-sexual-abuse-discovery-on-caregivers-and-families-a-qualitative-study
#19
Hiu-Fai Fong, Colleen E Bennett, Valerie Mondestin, Philip V Scribano, Cynthia Mollen, Joanne N Wood
In this qualitative study with nonoffending caregivers of suspected child sexual abuse victims, we aimed to explore the perceived impact of sexual abuse discovery on caregivers and their families, and caregivers' attitudes about mental health services for themselves. We conducted semistructured, in-person interviews with 22 nonoffending caregivers of suspected sexual abuse victims <13 years old seen at a child advocacy center in Philadelphia. Interviews were audio-recorded, transcribed, coded, and analyzed using modified grounded theory...
June 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294690/mediators-and-moderators-of-the-association-between-stalking-victimization-and-psychological-distress
#20
Connor R Fais, Catherine J Lutz-Zois, Jackson A Goodnight
The current study aims to understand mediators and moderators of the relationship between stalking victimization and depression. Based on the reformulated learned helplessness theory, which emphasizes the role of internal, global, and stable attributions for negative events in the development of depression, we predicted that the association between stalking victimization and depression would be mediated by attributions for the stalking and characterological self-blame. We predicted that the association between stalking victimization and helplessness attributions or characterological self-blame, in turn, would be moderated by gender, sex-role identity, and length of stalking...
March 1, 2017: Journal of Interpersonal Violence
keyword
keyword
1430
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"