Yizhong Peng, Xuanzuo Chen, Zilong Rao, Wei Wu, Huiyin Zuo, Kaibin Chen, Kanglu Li, Hui Lin, Sheng Liu, Yan Xiao, BaiChuan Wang, Daping Quan, Xiangcheng Qing, Ying Bai, Zengwu Shao
Chronic low back pain mainly attributed to intervertebral disc (IVD) degeneration. Endogenous damage-associated molecular patterns (DAMPs) in the injured IVD, particularly mitochondria-derived nucleic acid molecules (CpG DNA), play a primary role in the inflammatory responses in macrophages. M1-type macrophages form a chronic inflammatory microenvironment by releasing pro-inflammatory factors and nerve growth factor (NGF) that induce nerve growth into the inner annulus fibrosus, resulting in persistent hyperalgesia...
August 18, 2023: Acta Biomaterialia