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Balint group

Johannes Roth, Viviana Ravagnani, Marina Backhaus, Peter Balint, Alessandra Bruns, George A Bruyn, Paz Collado, Lorenia De la Cruz, Severine Guillaume-Czitrom, Troels Herlin, Cristina Hernandez, Annamaria Iagnocco, Sandrine Jousse-Joulin, Stefano Lanni, Vibke Lilleby, Clara Malattia, Silvia Magni-Manzoni, Consuelo Modesto, Ana Narrodi, Juan-Carlos Nieto, Sarah Ohrndorf, Linda Rossi, Anne-Marit Selvaag, Nanno Swen, Tracy Ting, Nikolay Tzaribachev, Patricia Vega-Fernandez, Jelena Vojinovic, Daniel Windschall, Maria-Antonietta D'Agostino, Esperanza Naredo
Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process...
October 16, 2016: Arthritis Care & Research
Mathieu Marmier, Giacomo Cecot, Anna V Vologzhanina, José L Bila, Ivica Zivkovic, Henrik M Ronnow, Balint Nafradi, Euro Solari, Philip Pattison, Rosario Scopelliti, Kay Severin
Dinuclear clathrochelate complexes with two, three, four, or five cyano groups in the ligand periphery were prepared following two distinct synthetic strategies: (a) zinc(ii)- or cobalt(ii)-templated polycondensation reactions of CN-functionalized arylboronic acids and phenoldioximes, or (b) postsynthetic cross-coupling reactions of polybrominated zinc(ii) clathrochelates with 4-cyanophenylboronic acid. The new clathrochelate complexes were used as metalloligands for the construction of heterometallic Zn(2+)/Ag(+) and Co(2+)/Ag(+) coordination polymers (CPs), which were characterized by single crystal X-ray diffraction and FT-IR...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Biljana Mihaljevic, Jelena Jelicic, Bosko Andjelic, Darko Antic, Olivera Markovic, Ivan Petkovic, Maja Perunicic Jovanovic, Goran Trajkovic, Jelena Bila, Vladislava Djurasinovic, Aleksandra Sretenovic, Vojin Vukovic, Mihailo Smiljanic, Milena Todorovic Balint
The Follicular Lymphoma International Prognostic Index (FLIPI) is widely used in the identification of risk groups among follicular lymphoma (FL) patients. The aim of the present study was to evaluate the prognostic value of FLIPI combined with the Charlson comorbidity index (CCI) and histological grade of lymphoma. 224 newly diagnosed FL patients (median age 56 years) treated with immunochemotherapy were retrospectively analysed. Low FLIPI had 21.0 % of patients, intermediate 28.1 % and high 46.9 %. 50...
October 6, 2016: International Journal of Hematology
Krisztina Voronova, Chrissa M Mozaffari Easter, Krisztián G Torma, Andras Bodi, Patrick Hemberger, Bálint Sztáray
The fragmentation processes of internal energy selected acetic acid anhydride cations, Ac2O(+), were investigated by imaging photoelectron photoion coincidence (iPEPICO) spectroscopy. The first dissociation channel leads to the formation of CH3C(O)OCO(+) (m/z = 87) by a CH3-loss. The 0 K appearance energy (E0) was determined to be 10.289 ± 0.010 eV, in excellent agreement with the G4-calculated 10.28 eV transition state (TS) energy. Based on the thermochemical onset of CH3C(O)OCO(+), a reverse barrier of 40 kJ mol(-1) was found...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
Ricardo H M Godoi, Sérgio J Gonçalves, Célia Sayama, Gabriela Polezer, José M Reis Neto, Bálint Alföldy, René Van Grieken, Carlos A Riedi, Carlos I Yamamoto, Ana F L Godoi, László Bencs
Serpentine and amphibole asbestos occur naturally in certain geologic settings worldwide, most commonly in association with ultramafic rocks, along associated faults. Ultramafic rocks have been used in Piên County, Southern Brazil for decades for the purpose of road paving in rural and urban areas, but without the awareness of their adverse environmental and health impact. The aim of this study was the chemical characterization of aerosols re-suspended in two rural roads of Piên, paved with ultramafic rocks and to estimate the pulmonary deposition of asbestos aerosols...
September 28, 2016: Environmental Science and Pollution Research International
Éva Borbély, Zsófia Hajna, Liza Nabi, Bálint Scheich, Valéria Tékus, Kristóf László, Tamás Ollmann, Viktória Kormos, Balázs Gaszner, Zoltán Karádi, László Lénárd, Christopher J Paige, John P Quinn, János Szolcsányi, Erika Pintér, Julie Keeble, Alexandra Berger, Zsuzsanna Helyes
The tachykinin NK1 receptor was suggested to be involved in psychiatric disorders, but its antagonists have failed to be effective as antidepressants in clinical trials. Hemokinin-1 (HK-1), the newest tachykinin, is present in several brain regions and activates the NK1 receptor similarly to substance P (SP), but acts also through other mechanisms. Therefore, we investigated the roles of the Tac4 gene-derived HK-1 in comparison with SP and neurokinin A (NKA) encoded by the Tac1 gene, as well as the NK1 receptor in anxiety and depression-like behaviors in mice...
September 9, 2016: Brain, Behavior, and Immunity
Jelena Bila, Aleksandra Sretenovic, Jelena Jelicic, Natasa Tosic, Irena Glumac, Marija Dencic Fekete, Darko Antic, Milena Todorovic Balint, Olivera Markovic, Zoran Milojevic, Milica Radojkovic, Goran Trajkovic, Mila Puric, Sonja Pavlovic, Biljana Mihaljevic
BACKGROUND: To personalize the treatment approach for patients with multiple myeloma (MM), molecular markers such as cereblon (CRBN) are currently the focus of investigation. The aim of the present study was to test the prognostic significance of CRBN expression in MM patients ineligible for autologous stem cell transplantation (ASCT). PATIENTS AND METHODS: The data from 92 previously untreated patients were analyzed. The distribution according to the International Staging System score was 26...
August 10, 2016: Clinical Lymphoma, Myeloma & Leukemia
B Gergely Szabo, B Kadar, K Szidonia Lenart, B Dezsenyi, P Kunovszki, K Fried, K Kamotsay, R Nikolova, G Prinz
There are only a limited number of antimicrobials for treating severe Clostridium difficile infection (sCDI). Tigecycline shows significant in vitro effect against C. difficile and is approved for management of complicated intra-abdominal infections. Our aim was to analyse the efficacy of tigecycline compared with standard therapy (oral vancomycin plus intravenous metronidazole) in adults treated for sCDI. A retrospective cohort study of such patients hospitalized at our department from January 2014 to December 2015 was performed...
September 4, 2016: Clinical Microbiology and Infection
Maria Antonietta D'Agostino, Lene Terslev, Richard Wakefield, Mikkel Østergaard, Peter Balint, Esperanza Naredo, Annamaria Iagnocco, Marina Backhaus, Walter Grassi, Paul Emery
The absence of specific guidance on how to use ultrasound (US) to diagnose and manage patients with inflammatory arthritis, especially with rheumatoid arthritis (RA) has hindered the optimal utilisation of US in clinical practice, potentially limiting its benefits for patient outcomes. In view of this, a group of musculoskeletal US experts formed a working group to consider how this unmet need could be satisfied and to produce guidance (additional to European League against Rheumatism (EULAR) imaging recommendations) to support clinicians in their daily clinical work...
November 2016: Annals of the Rheumatic Diseases
Elisabeth M Balint, Manuela Gander, Dan Pokorny, Alexandra Funk, Christiane Waller, Anna Buchheim
Hypertension is a major cardiovascular (CV) risk factor and is predicted by heightened CV reactivity to stress in healthy individuals. Patients with hypertension also show an altered stress response, while insecure attachment is linked to a heightened stress reactivity as well. This is the first study aiming to assess attachment representations in patients with primary hypertension and to investigate their CV responses when their attachment system is activated. We studied 50 patients (38 men, 12 women) with primary hypertension...
2016: Frontiers in Psychology
Anna Fábián, Renáta Bor, Anita Bálint, Klaudia Farkas, Ágnes Milassin, Mariann Rutka, László Tiszlavicz, Ferenc Nagy, Tamás Molnár, Zoltán Szepes
INTRODUCTION: Rectal ultrasonography is a basic method for staging rectal cancer. Tissue changes after neoadjuvant treatment alter the accuracy of the method. AIM: The aim of the authors was to assess the accuracy of rectal ultrasonography after preoperative chemo-radiotherapy compared to the initial staging accuracy. METHOD: Rectal ultrasounds performed between 2006 and 2014 were assessed retrospectively. Ultrasonographic and pathological T and N stages were compared both in case of initial staging (control group) and re-staging...
July 2016: Orvosi Hetilap
Bianka Edina Herman, Johanna Szabó, Ildikó Bacsa, János Wölfling, Gyula Schneider, Mónika Bálint, Csaba Hetényi, Erzsébet Mernyák, Mihály Szécsi
The inhibitory effects of 13-epimeric estrones, D-secooxime and D-secoalcohol estrone compounds on human placental 17β-hydroxysteroid dehydrogenase type 1 isozyme (17β-HSD1) were investigated. The transformation of estrone to 17β-estradiol was studied by an in vitro radiosubstrate incubation method. 13α-Estrone inhibited the enzyme activity effectively with an IC50 value of 1.2 μM, which indicates that enzyme affinity is similar to that of the natural estrone substrate. The 13β derivatives and the compounds bearing a 3-hydroxy group generally exerted stronger inhibition than the 13α and 3-ether counterparts...
July 18, 2016: Journal of Enzyme Inhibition and Medicinal Chemistry
Veronika Lóránd, Zsófia Bálint, Dalma Komjáti, Balázs Németh, Tünde Minier, Gábor Kumánovics, Nelli Farkas, László Czirják, Cecília Varjú
OBJECTIVES: To validate the Disease Activity Score 28 using ESR (DAS28-ESR) and CRP (DAS28-CRP), the Simplified Disease Activity Index and the Clinical Disease Activity Index used in RA for SSc patients. METHODS: Seventy-seven SSc patients, 40 RA patients, 20 patients with primary RP (PRP) and 28 healthy volunteers were assessed. Besides the disease activity composite indices, the European Scleroderma Study Group Activity Index (EScSG-AI), the HAQ-DI, the Cochin Hand Function Scale and the Short Form Health Survey (SF36) were evaluated...
October 2016: Rheumatology
Zsófia Kardos, Andrea Kóbor, Ádám Takács, Brigitta Tóth, Roland Boha, Bálint File, Márk Molnár
During daily encounters, it is inevitable that people take risks. Investigating the sequential processing of risk hazards involve expectation formation about outcome contingencies. The present study aimed to explore risk behavior and its neural correlates in sequences of decision making, particularly in old age, which represents a critical period regarding risk-taking propensity. The Balloon Analogue Risk Task was used in an electrophysiological setting with young and elderly age groups. During the task each additional pump on a virtual balloon increased the likelihood of a balloon burst but also increased the chance to collect more reward...
October 1, 2016: Behavioural Brain Research
Ádám Jóna, Zsófia Miltényi, Szilárd Póliska, Bálint László Bálint, Árpád Illés
BACKGROUND: Bleomycin hydrolase (BLMH), an enzyme that inactivates bleomycin, may be a potential candidate that could influence pulmonary function in ABVD (doxorubicin, bleomycin, vinblastin, dacarbasine)-treated Hodgkin lymphoma (HL) patients. PATIENTS AND METHODS: We hypothesized that the BLMH gene SNP A1450G (rs1050565) influences BLMH activity and late pulmonary toxicity. St. George Respiratory Questionnaire, lung scintigraphy and spirometry were used to determine lung function...
2016: PloS One
Gabriella Császárné Gombos, Viktória Bajsz, Emese Pék, Béla Schmidt, Eszter Sió, Bálint Molics, József Betlehem
BACKGROUND: Both gravitational loading and the forces generated by muscle contraction have direct effects on serum markers of bone metabolism. The object of this study was to examine the direct effects of a single session of resistance exercise or walking on biochemical markers of bone metabolism in participants with low bone mass. METHODS: A total of 150 otherwise healthy female subjects (mean age = 59.1 ± 7.1 years) diagnosed with osteoporosis or osteopenia were randomly allocated to either a resistance exercise group (RG; n = 50), walking group (WG; n = 50), or control group (CG; n = 50)...
2016: BMC Musculoskeletal Disorders
Zsófia Kardos, Brigitta Tóth, Roland Boha, Bálint File, Márk Molnár
Monitoring the consequences of actions is of crucial importance in order to optimize behavior to the challenges of the environment. Recently the age-related aspects of this fundamentally important cognitive processing have been brought into the focus of investigation since behavioral monitoring and related control mechanisms are widely known to be affected by aging. Processing of feedback stimuli is a core mechanism for rapid evaluation of the functionally significant aspects of outcome, guiding behavior towards avoidance or approach...
May 25, 2016: International Journal of Psychophysiology
Balint Farkas, Istvan Tiringer, Nelli Farkas, Balazs Kenyeres, Zoltan Nemeth
INTRODUCTION AND HYPOTHESIS: Until now, no valid Hungarian questionnaire has existed to evaluate the sexual quality of life of women with pelvic floor disorders. The aim of this study was to translate the Prolapse/Urinary Incontinence Sexual Questionnaire, IUGA-Revised (PISQ-IR), into Hungarian and to validate the translated PISQ-IR. METHODS: PISQ-IR was translated and validated using three steps, as guided by the IUGA international protocol: forward translation by two urogynecologists, a community review process consisting of one-on-one cognitive interviews with 20 patients, and backward translation by a native English speaker...
May 26, 2016: International Urogynecology Journal
Yuval Shorer, Stanley Rabin, Moshe Zlotnik, Nurit Cohen, Meir Nadav, Asher Shiber
Balint group (BG) is an experiential discussion group which deals with the various aspects of the therapist-patient relationship. BG was found to be effective for stress and burnout prevention among medical professionals. Burnout is expressed by emotional fatigue, de-personalization and sense of failure. Recent articles found connections between burnout and personal and systemic factors such as: workload, work conflicts, and work-life conflicts. Burnout can lead to medical mistakes, loss of empathy for the patient, coronary disease, and leaving work...
February 2016: Harefuah
Márton Kolossváry, Bálint Szilveszter, István Ferenc Édes, Sándor Nardai, Viktor Voros, István Hartyánszky, Béla Merkely, Szilard Voros, Pál Maurovich-Horvat
Numerous clinical studies using coronary computed tomography angiography (CTA) and conventional invasive coronary angiography (ICA) confirmed the strong relation between atherosclerotic disease burden and risk of adverse events. Few studies have compared coronary CTA and ICA regarding semiquantitative plaque burden measurements, reproducibility, and cardiovascular risk assessment. We enrolled 71 consecutive patients (mean age 62 ± 9 years, 37% women) from the Genetic Loci and the Burden of Atherosclerotic Lesions study (NCT01738828), who underwent 256-slice multidetector row coronary CTA and ICA at a single site...
June 15, 2016: American Journal of Cardiology
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