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https://www.readbyqxmd.com/read/29036655/mfib-a-repository-of-protein-complexes-with-mutual-folding-induced-by-binding
#1
Erzsébet Fichó, István Reményi, István Simon, Bálint Mészáros
Motivation: It is commonplace that intrinsically disordered proteins (IDPs) are involved in crucial interactions in the living cell. However, the study of protein complexes formed exclusively by IDPs is hindered by the lack of data and such analyses remain sporadic. Systematic studies benefited other types of protein-protein interactions paving a way from basic science to therapeutics; yet these efforts require reliable datasets that are currently lacking for synergistically folding complexes of IDPs...
August 3, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28981247/-the-general-practitioner-confronted-with-aggressive-patients
#2
M Schetgen
The general practitioner is regularly confronted with aggressive patients. He will have to spot the very first signs in order to manage as quickly as possible such a situation. The ideal is to remain calm, to listen actively and to try to understand the cause of the aggressiveness, knowing that it is not always directed against the doctor. Putting limits is also important to avoid situations that could degenerate. The generalist must also be able to share his difficult experiences with his colleagues, among others in the framework of a Balint group...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28974179/-designing-the-doctor-patient-relationship
#3
Guido Flatten, Heidi Möller, Jan Aden, Volker Tschuschke
Designing the doctor-patient relationship: How beneficial are Balint groups and for whom? OBJECTIVES: Participation in Balint groups is obligatory for some medical specialist trainings. Yet there is a substantial lack of empirical evidence for Balint group effects. METHODS: 1,460 medical specialists who participated in 352 different Balint groups were investigated using the Balint Group Questionnaire (BG-F) at the end of a Balint group session. Using mixed-model analyses, we examined the predictive value of the independent variables Experience in Balint Groups (in years), Clinical Experience in General (in years), Case Presentation vs...
September 2017: Zeitschrift Für Psychosomatische Medizin und Psychotherapie
https://www.readbyqxmd.com/read/28971392/psychodynamic-leadership-approach-and-leader-member-exchange-lmx-a-psychiatric-perspective-on-two-leadership-theories-and-implications-for-training-future-psychiatrist-leaders
#4
Christos Plakiotis
An increased emphasis in recent years on psychiatrists as healthcare leaders has not only drawn attention to the skills they can bring to this role but has also raised questions about how to best train and prepare them to assume leadership responsibilities. Such training should not be conducted in isolation from, and oblivious to, the wide-ranging expertise in human behaviour and relationships that psychiatrists can bring to the leadership arena. The aim of this theoretical paper is to draw attention to how psychiatrists can use their existing knowledge and skill set to inform their understanding of leadership theory and practice...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28956169/clinical-improvement-of-patients-with-osteoarthritis-using-thermal-mineral-water-at-szigetv%C3%A3-r-spa-results-of-a-randomised-double-blind-controlled-study
#5
Adrienn Hanzel, Krisztina Horvát, Bálint Molics, Károly Berényi, Balázs Németh, Katalin Szendi, Csaba Varga
Since 1966, Szigetvár in Hungary is well recognised as a thermal spa. Many patients suffering from rheumatic diseases are treated with its thermal mineral water. Our objective was to investigate the effects of a 3-week-long outpatient balneotherapy-based rehabilitation program on patients suffering from osteoarthritis of the hips and the knees. During the treatment period, patients received a 30-min underwater jet massage in a bath tub, five times a week. One patient group received jet massage in a bath tub containing mineral water; the other group received the same treatment in tap water...
September 27, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28934677/evaluation-of-participatory-planning-lessons-from-hungarian-natura-2000-management-planning-processes
#6
Eszter Kovács, Eszter Kelemen, Gabriella Kiss, Ágnes Kalóczkai, Veronika Fabók, Barbara Mihók, Boldizsár Megyesi, György Pataki, Barbara Bodorkós, Bálint Balázs, Györgyi Bela, Katalin Margóczi, Ágnes Roboz, Dániel Molnár
Stakeholder participation in nature conservation policies and especially in the management of protected areas has gained importance in the last decades. These changes are underlined by democratic principles and the perceived contribution of stakeholder involvement to the effectiveness of conservation management. Evaluating participatory processes is essential to learn about the past and thus increase the quality of future processes. The evaluation can be useful for the organisations responsible for planning and management, stakeholders and policy makers as well...
December 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28934308/devices-and-tasks-involved-in-the-objective-assessment-of-standing-dynamic-balancing-a-systematic-literature-review
#7
Bálint Petró, Alexandra Papachatzopoulou, Rita M Kiss
BACKGROUND: Static balancing assessment is often complemented with dynamic balancing tasks. Numerous dynamic balancing assessment methods have been developed in recent decades with their corresponding balancing devices and tasks. OBJECTIVE: The aim of this systematic literature review is to identify and categorize existing objective methods of standing dynamic balancing ability assessment with an emphasis on the balancing devices and tasks being used. DATA SOURCES: Three major scientific literature databases (Science Direct, Web of Science, PLoS ONE) and additional sources were used...
2017: PloS One
https://www.readbyqxmd.com/read/28885747/palladium-catalyzed-2-2-2-trifluoroethoxylation-of-aromatic-and-heteroaromatic-chlorides-utilizing-borate-salt-and-the-synthesis-of-a-trifluoro-analogue-of-sildenafil
#8
Bálint Pethő, Márton Zwillinger, János T Csenki, Anna E Káncz, Balázs Krámos, Judit Müller, György T Balogh, Zoltán Novák
A simple and convenient method was developed for the introduction of a 2,2,2-trifluoroethoxy group to various aromatic and heteroaromatic systems. The novel process utilizes aromatic chlorides as substrates, and tetrakis(2,2,2-trifluoroethoxy) borate salt as an inexpensive and readily available fluoroalkoxy source in a palladium-catalyzed cross-coupling reaction. The power of the developed methodology was demonstrated in the synthesis of a fluorous derivative of Sildenafil.
September 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28869417/efficacy-of-intensive-hand-physical-therapy-in-patients-with-systemic-sclerosis
#9
József Horváth, Zsófia Bálint, Erika Szép, Aletta Deiszinger, Tünde Minier, Nelli Farkas, Enikő Török, Éva Horváthné Papp, Dalma Komjáti, Zsuzsanna Mándó, László Czirják, Cecilia Varjú
OBJECTIVES: To evaluate the efficacy of a three-week period of complex and intensive hand physical therapy on hand function in patients with systemic sclerosis (SSc). METHODS: Thirty-one patients with SSc were treated. Hand stretching exercises, ergotherapy supplemented with thermal and mud baths, whirlpool therapy and soft tissue massage were daily used during a three-week period. The control SSc group (n=22) received similar management for their large joints leaving out their hands...
August 30, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28858493/enantiospecific-solvolytic-functionalization-of-bromochlorides
#10
Alexander J Burckle, Bálint Gál, Frederick J Seidl, Vasil H Vasilev, Noah Z Burns
Herein, we report that under mild solvolytic conditions, enantioenriched bromochlorides can be ionized, stereospecifically cyclized to an array of complex bromocyclic scaffolds, or intermolecularly trapped by exogenous nucleophiles. Mechanistic investigations support an ionic mechanism wherein the bromochloride serves as an enantioenriched bromonium surrogate. Several natural product-relevant motifs are accessed in enantioenriched form for the first time with high levels of stereocontrol, and this technology is applied to the scalable synthesis of a polycyclic brominated natural product...
September 18, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28847177/-evaluation-of-anatomic-and-prognostic-stages-of-breast-cancer-according-to-the-8th-edition-of-the-tnm-staging-system-retrospective-analysis-based-on-data-from-deceased-patients-once-diagnosed-with-breast-cancer
#11
Tamás Zombori, Luca Lehóczky, Bálint Cserni, Tibor Nyári, Gábor Cserni
INTRODUCTION: The 8th edition of the Tumor-Node-Metastasis (TNM) based staging of breast cancer introduces a prognostic stage influenced by biomarkers along the traditional T, N and M categories. AIM: To retrospectively assess stage influencing prognostic variables; and the anatomic and prognostic stages on the basis of the overall survival (OS) of a cohort of deceased patients once diagnosed with breast cancer. METHOD: We included patients with known causes of death certified at the Bács-Kiskun County Teaching Hospital and having a history of breast cancer diagnosed on a resection specimen at the same institution...
September 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28814430/the-2017-eular-standardised-procedures-for-ultrasound-imaging-in-rheumatology
#12
Ingrid Möller, Iustina Janta, Marina Backhaus, Sarah Ohrndorf, David A Bong, Carlo Martinoli, Emilio Filippucci, Luca Maria Sconfienza, Lene Terslev, Nemanja Damjanov, Hilde Berner Hammer, Iwona Sudol-Szopinska, Walter Grassi, Peter Balint, George A W Bruyn, Maria Antonietta D'Agostino, Diana Hollander, Heidi J Siddle, Gabriela Supp, Wolfgang A Schmidt, Annamaria Iagnocco, Juhani Koski, David Kane, Daniela Fodor, Alessandra Bruns, Peter Mandl, Gurjit S Kaeley, Mihaela Micu, Carmen Ho, Violeta Vlad, Mario Chávez-López, Georgios Filippou, Carmen Elena Cerón, Rodina Nestorova, Maritza Quintero, Richard Wakefield, Loreto Carmona, Esperanza Naredo
BACKGROUND: In 2001, the European League Against Rheumatism developed and disseminated the first guidelines for musculoskeletal (MS) ultrasound (US) in rheumatology. Fifteen years later, the dramatic expansion of new data on MSUS in the literature coupled with technological developments in US imaging has necessitated an update of these guidelines. OBJECTIVES: To update the existing MSUS guidelines in rheumatology as well as to extend their scope to other anatomic structures relevant for rheumatology...
August 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28777893/age-related-vascularization-and-ossification-of-joints-in-children-an-international-pilot-study-to-test-multi-observer-ultrasound-reliability
#13
Daniel Windschall, Paz Collado, Jelena Vojinovic, Silvia Magni-Manzoni, Peter Balint, George A W Bruyn, Cristina Hernandez-Diaz, Juan Carlos Nieto, Viviana Ravagnani, Nikolay Tzaribachev, Annamaria Iagnocco, Maria Antonietta D'Agostino, Esperanza Naredo
OBJECTIVE: To determine the intra- and inter-observer reliability of ultrasound (US)-detected age-related joint vascularization and ossification grading in healthy children. METHODS: Following standardized image acquisition and machine setting protocols, 10 international US experts examined four joints (wrist, second metacarpophalangeal joint, knee, and ankle) in 12 healthy children (divided into four age groups: 2-4, 5-8, 9-12, and 13-16 years). Grey-scale was used to detect the ossification grade, and power Doppler (PD) US was used to detect physiological vascularization...
August 4, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28716112/psychosocial-interventions-for-managing-occupational-stress-and-burnout-among-medical-doctors-a-systematic-review
#14
Bonnie A Clough, Sonja March, Raymond J Chan, Leanne M Casey, Rachel Phillips, Michael J Ireland
BACKGROUND: Occupational stress and burnout are highly prevalent among medical doctors and can have adverse effects on patient, doctor, and organisational outcomes. The purpose of the current study was to review and evaluate evidence on psychosocial interventions aimed at reducing occupational stress and burnout among medical doctors. METHOD: A systematic review was conducted for original research articles reporting on psychosocial interventions targeting occupational stress or burnout among medical doctors, published in the English language, and with data collected at a minimum of two time points...
July 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28708356/-what-remains-of-our-balints
#15
Régis Marion-Veyron, Konstantinos Tzartzas, Michael Saraga
In addition to providing psychiatric care to patients with somatic diseases, liaison psychiatry plays a role in the teaching of the relational aspects of medical practice. This series of three articles offers a critical reflection on this topic and examples of educational programs developed at Lausanne University Hospital. In the Department of Ambulatory Care and Community Medicine, an intervention inspired by Balint groups offers to residents in general internal medicine the possibility of working through their clinical experiences and their evolving professional identity...
February 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28540480/the-effect-of-four-phasic-versus-three-phasic-contrast-media-injection-protocols-on-extravasation-rate-in-coronary-ct-angiography-a-randomized-controlled-trial
#16
Júlia Karády, Alexisz Panajotu, Márton Kolossváry, Bálint Szilveszter, Ádám L Jermendy, Andrea Bartykowszki, Mihály Károlyi, Csilla Celeng, Béla Merkely, Pál Maurovich-Horvat
OBJECTIVES: Contrast media (CM) extravasation is a well-known complication of CT angiography (CTA). Our prospective randomized control study aimed to assess whether a four-phasic CM administration protocol reduces the risk of extravasation compared to the routinely used three-phasic protocol in coronary CTA. METHODS: Patients referred to coronary CTA due to suspected coronary artery disease were included in the study. All patients received 400 mg/ml iomeprol CM injected with dual-syringe automated injector...
May 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28434244/-helping-reintegration-of-patients-suffering-from-chronic-musculoskeletal-diseases-with-decreased-working-ability-in-the-national-institute-of-rheumatology-and-physiotherapy-budapest-hungary
#17
Julianna Rozália Sallai, Aniella Hunka, Gábor Héjj, Géza Bálint, Gyula Poór
INTRODUCTION: An important task of our institute is to support social reintegration: including occupational rehabilitation of patients suffering from chronic musculoskeletal diseases with decreased working ability. AIM: The aim of the authors was to provide informations of their daily practice, how they perform patient education, giving information for their patients about their disease, the rehabilitation possibilities, how they support the patients with decreased working ability to take part in their own rehabilitation...
April 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28432341/detection-of-red-blood-cell-surface-antigens-by-probe-triggered-cell-collision-and-flow-retardation-in-an-autonomous-microfluidic-system
#18
Éva Sautner, Krisztián Papp, Eszter Holczer, Eszter L Tóth, Rita Ungai-Salánki, Bálint Szabó, Péter Fürjes, József Prechl
Microfluidic devices exploit combined physical, chemical and biological phenomena that could be unique in the sub-millimeter dimensions. The current goal of development of Point-of-Care (POC) medical devices is to extract the biomedical information from the blood. We examined the characteristics of blood flow in autonomous microfluidic devices with the aim to realize sensitive detection of interactions between particulate elements of the blood and the appropriately modified surfaces of the system. As a model experiment we demonstrated the fast analysis of the AB0 blood group system...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28420689/-the-year-of-first-aid-effectiveness-of-a-3-day-first-aid-programme-for-7-14-year-old-primary-school-children
#19
Balint Banfai, Emese Pek, Attila Pandur, Henrietta Csonka, Jozsef Betlehem
AIM OF THE STUDY: Bystanders can play an important role in the event of sudden injury or illness. Our aim was to evaluate the effects of a 3-day first aid course for all primary school age groups (7-14 years old). METHODS: 582 school children were involved in the study. Training consisted of three sessions with transfer of theoretical knowledge and practical skills about first aid. The following most urgent situations were addressed in our study: adult basic life support (BLS), using an automated external defibrillator (AED), handling an unconscious patient, managing bleeding and calling the ambulance...
August 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28362851/clinical-role-optimal-timing-and-frequency-of-serum-infliximab-and-anti-infliximab-antibody-level-measurements-in-patients-with-inflammatory-bowel-disease
#20
Renáta Bor, Klaudia Farkas, Anna Fábián, Anita Bálint, Ágnes Milassin, Mariann Rutka, Mária Matuz, Ferenc Nagy, Zoltán Szepes, Tamás Molnár
BACKGROUND: Serum infliximab (IFX) and antibody-to-infliximab (ATI) levels are objective parameters, that may have a great role in the therapeutic decisions during maintenance biological therapy. RESEARCH DESIGN AND METHODS: 48 inflammatory bowel disease patients receiving maintenance IFX therapy were prospectively enrolled and divided into adequate (complete remission N = 20) and inadequate responder (partial response, loss of response, dose escalation; N = 28) groups...
2017: PloS One
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