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https://www.readbyqxmd.com/read/29459325/discontinuous-schedule-of-bevacizumab-in-colorectal-cancer-induces-accelerated-tumor-growth-and-phenotypic-changes
#1
Selma Becherirat, Fatemeh Valamanesh, Mojgan Karimi, Anne-Marie Faussat, Jean-Marie Launay, Cynthia Pimpie, Amu Therwath, Marc Pocard
Antiangiogenics administration in colorectal cancer patients seemed promising therapeutic approach. Inspite of early encouraging results, it however gave only modest clinical benefits. When AAG was administered with discontinuous schedule, the disease showed acceleration in certain cases. Though resistance to AAG has been extensively studied, it is not documented for discontinuous schedules. To simulate clinical situations, we subjected a patient-derived CRC subcutaneous xenograft in mice to three different protocols: 1) AAG (bevacizumab) treatment for 30 days (group A) (group B was the control), 2) bevacizumab treatment for 50 days (group C) and bevacizumab for 30 days and 20 without treatment (group D), and 3) bevacizumab treatment for 70 days (group E) and 70 days treatment with a drug-break period between day 30 and 50 (group F)...
February 16, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29443432/bioorthogonal-metabolic-cellular-dna-labelling-using-vinyl-thioether-modified-thymidine-and-o-quinolinone-quinone-methide
#2
Amu Gubu, Long Li, Ning Yan, Xiaoyun Zheng, Seonghyun Lee, Mengke Feng, Qiang Li, Xiaoguang Lei, Kyubong Jo, Xinjing Tang
Bioorthogonal metabolic DNA labelling with fluorochromes is a powerful strategy to visualize DNA molecules and their functions. Herein, we report the development of a new DNA metabolic labelling strategy enabled by the catalyst-free bioorthogonal ligation using vinyl thioether modified thymidine and o-quinolinone quinone methide. With the newly designed vinyl thioether-modified thymidine (VTdT), we added labelling tags on cellular DNA, which could further be linked to fluorochromes in cells. Therefore, we successfully visualized the DNA localization within cells as well as single DNA molecules without other staining reagents...
February 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29417001/locomotor-problems-among-rural-elderly-population-in-a-district-of-aligarh-north-india
#3
Mohd Maroof, Anees Ahmad, Najam Khalique, M Athar Ansari
Introduction: Locomotor functions decline with the age along with other physiological changes. This results in deterioration of the quality of life with decreased social and economic role in the society, as well as increased dependency, for the health care and other basic services. The demographic transition resulting in increased proportion of elderly may pose a burden to the health system. Objectives: To find the prevalence of locomotor problems among the elderly population, and related sociodemographic factors...
July 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29413997/burkholderia-sacchari-dsm-17165-a-source-of-compositionally-tunable-block-copolymeric-short-chain-poly-hydroxyalkanoates-from-xylose-and-levulinic-acid
#4
Richard D Ashby, Daniel K Y Solaiman, Alberto Nuñez, Gary D Strahan, David B Johnston
Burkholderia sacchari was used to produce poly-3-hydroxybutyrate-co-3-hydroxyvalerate block copolymers from xylose and levulinic acid. Levulinic acid was the preferred substrate resulting in 3-hydroxyvalerate (3HV) contents as high as 95 mol% at 24 h. The 3HB:3HV ratios were controlled by the initial levulinic acid media concentration and fermentation length. Higher levulinic acid concentrations and longer durations, resulted in polymers with two glass transition temperatures, each approximating those associated with poly-3HB and poly-3HV...
December 18, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29409561/validation-of-the-register-based-lifetime-antimicrobial-usage-measurement-for-finisher-batches-based-on-comparison-with-recorded-antimicrobial-usage-at-farm-level
#5
V D Andersen, P Munk, L V de Knegt, M S Jensen, F M Aarestrup, H Vigre
Assessing the relationship between antimicrobial usage (AMU) and antimicrobial resistance (AMR) requires the accurate and precise utilisation of register data. Therefore, validation of register-based data is essential for evaluating the quality and, subsequently, the internal validity of studies based on the data. In this study, different smoothing methods for Veterinary Medicine Statistic Program database (VetStat)-records were validated by comparing these with farm-records. Comparison between measurements included accuracy as; completeness and correctness, and precision as; a relative difference of the error, correlation with Fisher's z transformation and reliability coefficient...
February 7, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29408979/the-provision-of-seven-day-multidisciplinary-staffing-in-scottish-acute-medical-units-a-cross-sectional-study
#6
L E M Reid, N I Lone, Z J Morrison, C J Weir, M C Jones
Background: Acute medical units (AMUs) are a central component of the admission pathway for the majority of medical patients presenting to hospital in the United Kingdom (UK) and other international settings. Detail on multidisciplinary staffing provision on weekdays and weekends is lacking. Equity of staffing across seven days is a strategic priority for national health services in the UK. Aim: To evaluate weekday compared with weekend multidisciplinary staffing in a national set of AMUs...
February 2, 2018: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/29370148/the-enhanced-red-emission-and-improved-thermal-stability-of-caalsin%C3%A2-eu2-phosphors-by-using-nano-eub%C3%A2-as-raw-material
#7
Wen-Quan Liu, Dan Wu, Hugejile Chang, Ru-Xia Duan, Wen-Jie Wu, Guleng Amu, Ke-Fu Chao, Fu-Quan Bao, Ojiyed Tegus
Synthesizing phosphors with high performance is still a necessary work for phosphor-converted white light-emitting diodes (W-LEDs). In this paper, three series of CaAlSiN₃:Eu2+ (denoted as CASN:Eu2+) phosphors using Eu₂O₃, EuN and EuB₆ as raw materials respectively are fabricated by under the alloy precursor normal pressure nitridation synthesis condition. We demonstrate that CASN:Eu2+ using nano-EuB₆ as raw material shows higher emission intensity than others, which is ascribed to the increment of Eu2+ ionic content entering into the crystal lattice...
January 25, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29369618/microwave-spectra-structure-and-the-aromatic-character-of-1-chloroborepin
#8
Aaron M Pejlovas, Zunwu Zhou, Arthur James Ashe, Stephen George Kukolich
High resolution microwave spectra for the somewhat unstable compound, 1-chloroborepin were measured in the 5-10 GHz range using a pulsed beam Fourier transform microwave spectrometer. Transitions were assigned and measured for three isotopologues, which include the most abundant isotopologue, 11B35Cl, and the less abundant 10B35Cl and 11B37Cl isotopologues. The molecular parameters (in MHz) determined for the 11B35Cl isotopologue are A = 3490.905(35), B = 1159.38520(79), C = 870.59492(56), 1.5χaa (11B) = -0...
January 25, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29328339/reduced-sintering-of-mass-selected-au-clusters-on-sio2-by-alloying-with-ti-an-aberration-corrected-stem-and-computational-study
#9
Yubiao Niu, Philomena Schlexer, Bela Sebok, Ib Chorkendorff, Gianfranco Pacchioni, Richard E Palmer
Au nanoparticles represent the most remarkable example of a size effect in heterogeneous catalysis. However, a major issue hindering the use of Au nanoparticles in technological applications is their rapid sintering. We explore the potential of stabilizing Au nanoclusters on SiO2 by alloying them with a reactive metal, Ti. Mass-selected Au/Ti clusters (400 000 amu) and Au2057 clusters (405 229 amu) were produced with a magnetron sputtering, gas condensation cluster beam source in conjunction with a lateral time-of-flight mass filter, deposited onto a silica support and characterised by XPS and LEIS...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29310599/birthplace-choices-what-are-the-information-needs-of-women-when-choosing-where-to-give-birth-in-england-a-qualitative-study-using-online-and-face-to-face-focus-groups
#10
Lisa Hinton, Carol Dumelow, Rachel Rowe, Jennifer Hollowell
BACKGROUND: Current clinical guidelines and national policy in England support offering 'low risk' women a choice of birth setting. Options include: home, free-standing midwifery unit (FMU), alongside midwifery unit (AMU) or obstetric unit (OU). This study, which is part of a broader project designed to inform policy on 'choice' in relation to childbirth, aimed to provide evidence on UK women's experiences of choice and decision-making in the period since the publication of the Birthplace findings (2011) and new NICE guidelines (2014)...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29305779/evidence-of-glucuronidation%C3%A2-of-the-glycation-product-lw-1-tentative-structure-and-implications-for-the-long-term-complications-of-diabetes
#11
David R Sell, Ina Nemet, Zhili Liang, Vincent M Monnier
LW-1 is a collagen-linked blue fluorophore whose skin levels increase with age, diabetes and end-stage renal disease (ESRD), and correlate with the long-term progression of microvascular disease and indices of subclinical cardiovascular disease in type 1 diabetes. The chemical structure of LW-1 is still elusive, but earlier NMR analyses showed it has a lysine residue in an aromatic ring coupled to a sugar molecule reminiscent of advanced glycation end-products (AGEs). We hypothesized and demonstrate here that the unknown sugar is a N-linked glucuronic acid...
January 5, 2018: Glycoconjugate Journal
https://www.readbyqxmd.com/read/29273972/the-first-report-of-japanese-antimicrobial-use-measured-by-national-database-based-on-health-insurance-claims-data-2011-2013-comparison-with-sales-data-and-trend-analysis-stratified-by-antimicrobial-category-and-age-group
#12
Daisuke Yamasaki, Masaki Tanabe, Yuichi Muraki, Genta Kato, Norio Ohmagari, Tetsuya Yagi
PURPOSE: Our objective was to evaluate the utility of the national database (NDB) based on health insurance claims data for antimicrobial use (AMU) surveillance in medical institutions in Japan. METHODS: The population-weighted total AMU expressed as defined daily doses (DDDs) per 1000 inhabitants per day (DID) was measured by the NDB. The data were compared with our previous study measured by the sales data. Trend analysis of DID from 2011 to 2013 and subgroup analysis stratified by antimicrobial category and age group were performed...
December 22, 2017: Infection
https://www.readbyqxmd.com/read/29220443/retrogenedb-a-database-of-plant-and-animal-retrocopies
#13
Wojciech Rosikiewicz, Michal Kabza, Jan G Kosinski, Joanna Ciomborowska-Basheer, Magdalena R Kubiak, Izabela Makalowska
Database URL: http://yeti.amu.edu.pl/retrogenedb. Secondary database URL: http://rhesus.amu.edu.pl/retrogenedb.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29205846/use-and-clinical-efficacy-of-standard-and-health-information-technology-fall-risk-assessment-tools
#14
Ruth C Teh, Anne Wilson, Damith Ranasinghe, Renuka Visvanathan
OBJECTIVE: To evaluate the health information technology (HIT) compared to Fall Risk for Older Persons (FROP) tool in fall risk screening. METHODS: A HIT tool trial was conducted on the geriatric evaluation and management (GEM, n = 111) and acute medical units (AMU, n = 424). RESULTS: Health information technology and FROP scores were higher on GEM versus AMU, with no differences between people who fell and people who did not fall. Both score completion rates were similar, and their values correlated marginally (Spearman's correlation coefficient 0...
December 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29204195/magnitude-of-neurogenic-tumor-burden-in-pediatric-population-a-tertiary-care-center-study
#15
Shagufta Qadri, Mahboob Hasan, Kafil Akhtar
Objective: Progress in the diagnosis and treatment of childhood neoplasm in the past few decades is one of the most gratifying achievements in the field of oncology. This study was aimed to ascertain the burden (incidence and prevalence) and histopathologic features of neurogenic tumors occurring in the pediatric population. Materials and Methods: The study evaluated a total of 492 cases of pediatric tumors over a period of 8 years from 2007 to 2015, including patients of 0-12 years of age group; attending the out-patients and in-patients Department of Pediatrics and Pediatric Surgery at Jawaharlal Nehru Medical College, AMU, Aligarh, with the complaints of tumor or tumor associated sign and symptoms...
July 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/29165600/missed-opportunities-to-identify-occupational-asthma-in-acute-secondary-care
#16
P R Ellis, G I Walters
Background: Occupational asthma (OA) accounts for one in six cases of new-onset adult asthma. Despite this it remains under-recognized in the UK. Delayed and missed diagnoses of OA lead to poor health outcomes for workers at significant cost to the UK economy. The burden of occupational aetiology on hospital admissions with asthma is not known. Aims: To measure how frequently medical professionals consider occupational aetiology in patients presenting to secondary care with acute asthma symptoms...
November 18, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29130790/performance-evaluation-of-a-miniature-magnetic-sector-mass-spectrometer-onboard-a-satellite-in-space
#17
Meiru Guo, Detain Li, Yongjun Cheng, Yongjun Wang, Wenjun Sun, Xiaoqiang Pei, Meng Dong, Xuemin Sheng, Lan Zhao, Yanwu Li
With the rapid development of space technology in China, it is urgent to use mass spectrometer to detect the space environment. In this work, a space miniature magnetic sector mass spectrometer is evaluated, which consists of three subsystems: (1) physical unit, (2) electric control unit, (3) and high voltage power. It has 90° magnetic sector-field analyzer with double trajectory, in which a trajectory measurement range is from 1 to 12 amu, the other range is from 6 to 90 amu.The mass spectrometer has two work models, one is used to measure space neutral gas when the filament of mass spectrometer ion source turned on, the other is used to measure space charged ions when the filament turned off...
January 1, 2017: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/29115071/an-acute-medical-unit-in-a-korean-tertiary-care-hospital-reduces-the-length-of-stay-and-waiting-time-in-the-emergency-department
#18
Jung Hun Ohn, Nak Hyun Kim, Eun Sun Kim, Seon Ha Baek, Yejee Lim, Jaehyung Hur, Yun Jong Lee, Eu Suk Kim, Hak Chul Jang
A hospitalist-run acute medical unit (AMU) opened at a tertiary care hospital on August 2015 for the first time in Korea. Patients visiting the emergency department (ED) with acute medical problems are admitted to the AMU. They stay in that unit for less than 72 hours and are discharged or transferred to specialty wards if longer treatment is necessary. We reviewed 19,450 medical admissions through the ED from January 2014 to September 2016. The median length of stay (LOS) significantly decreased from 10.0 days (interquartile range [IQR], 5...
December 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29092461/orthogonal-time-of-flight-mass-spectrometry-of-an-ion-beam-with-a-broad-kinetic-energy-profile
#19
S W Miller, B D Prince, R J Bemish
A combined experimental and modeling effort is undertaken to assess a detection system composed of an orthogonal extraction time-of-flight (TOF) mass spectrometer coupled to a continuous ion source emitting an ion beam with kinetic energy of several hundred eV. The continuous ion source comprises an electrospray capillary system employing an undiluted ionic liquid emitting directly into vacuum. The resulting ion beam consists of ions with kinetic energy distributions of width greater than a hundred of eV and mass-to-charge (m/q) ratios ranging from 111 to 500 000 amu/q...
October 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/29083871/phase-transition-of-h2-in-subnanometer-pores-observed-at-75-k
#20
Raina J Olsen, Andrew K Gillespie, Cristian I Contescu, Jonathan W Taylor, Peter Pfeifer, James R Morris
Here we report a phase transition in H2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5-0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H2 is stabilized by the surface structure. Here we observe a transition at 75 K and 77-200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase...
November 7, 2017: ACS Nano
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