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https://www.readbyqxmd.com/read/28333646/recurrent-neural-networks-with-auxiliary-memory-units
#1
Jianyong Wang, Lei Zhang, Quan Guo, Zhang Yi
Memory is one of the most important mechanisms in recurrent neural networks (RNNs) learning. It plays a crucial role in practical applications, such as sequence learning. With a good memory mechanism, long term history can be fused with current information, and can thus improve RNNs learning. Developing a suitable memory mechanism is always desirable in the field of RNNs. This paper proposes a novel memory mechanism for RNNs. The main contributions of this paper are: 1) an auxiliary memory unit (AMU) is proposed, which results in a new special RNN model (AMU-RNN), separating the memory and output explicitly and 2) an efficient learning algorithm is developed by employing the technique of error flow truncation...
March 21, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28323856/risk-factors-for-esbl-producing-escherichia-coli-on-pig-farms-a-longitudinal-study-in-the-context-of-reduced-use-of-antimicrobials
#2
Wietske Dohmen, Alejandro Dorado-García, Marc J M Bonten, Jaap A Wagenaar, Dik Mevius, Dick J J Heederik
The presence of extended-spectrum beta-lactamase-producing Escherichia coli (ESBL-E. coli) in food animals is a public health concern. This study aimed to determine prevalence of ESBL-E. coli on pig farms and to assess the effect of reducing veterinary antimicrobial use (AMU) and farm management practices on ESBL-E. coli occurrence on pig farms. During 2011-2013, 36 Dutch conventional pig farms participated in a longitudinal study (4 sampling times in 18 months). Rectal swabs were taken from 60 pigs per farm and pooled per 6 pigs within the same age category...
2017: PloS One
https://www.readbyqxmd.com/read/28320352/a-comparison-of-intrapartum-interventions-and-adverse-outcomes-by-parity-in-planned-freestanding-midwifery-unit-and-alongside-midwifery-unit-births-secondary-analysis-of-low-risk-births-in-the-birthplace-in-england-cohort
#3
Jennifer Hollowell, Yangmei Li, Kathryn Bunch, Peter Brocklehurst
BACKGROUND: For low risk women, there is good evidence that planned birth in a midwifery unit is associated with a reduced risk of maternal interventions compared with planned birth in an obstetric unit. Findings from the Birthplace cohort study have been interpreted by some as suggesting a reduced risk of interventions in planned births in freestanding midwifery units (FMUs) compared with planned births in alongside midwifery units (AMUs). However, possible differences have not been robustly investigated using individual-level Birthplace data...
March 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28293768/the-utility-of-a-medical-admissions-pharmacist-in-a-hospital-in-australia
#4
Sally B Marotti, Rachael May Theng Cheh, Anne Ponniah, Helen Phuong
Background Medication-related hospital admissions in Australia have previously been estimated to account for approximately 3% of all hospital admissions, with hospital entry points being a point of vulnerability. The timely medication review and reconciliation by a pharmacist at the early stage of an admission for patients admitted to the Acute Medical Unit (AMU) would be beneficial. Setting The Emergency Department (ED) and AMU in a 300 bed tertiary teaching hospital, in South Australia. Objective To investigate the impact of a Medical Admissions (MA) pharmacist on the proportion of AMU patients who receive a complete and accurate medication history by a pharmacist prior to admission and within 4 h of presentation...
March 15, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/28276533/immunogenicity-is-preferentially-induced-in-sparse-dendritic-cell-cultures
#5
Aikaterini Nasi, Vishnu Priya Bollampalli, Meng Sun, Yang Chen, Sylvie Amu, Susanne Nylén, Liv Eidsmo, Antonio Gigliotti Rothfuchs, Bence Réthi
We have previously shown that human monocyte-derived dendritic cells (DCs) acquired different characteristics in dense or sparse cell cultures. Sparsity promoted the development of IL-12 producing migratory DCs, whereas dense cultures increased IL-10 production. Here we analysed whether the density-dependent endogenous breaks could modulate DC-based vaccines. Using murine bone marrow-derived DC models we show that sparse cultures were essential to achieve several key functions required for immunogenic DC vaccines, including mobility to draining lymph nodes, recruitment and massive proliferation of antigen-specific CD4+ T cells, in addition to their TH1 polarization...
March 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28103402/do-same-sex-mounts-function-as-dominance-assertion-in-male-golden-snub-nosed-monkeys-rhinopithecus-roxellana
#6
Pengzhen Huang, Xin He, Endi Zhang, Min Chen
It has been hypothesized that same-sex mounts can reflect the hierarchical relationship in a mounting dyad and it is widely deemed that mounting and being mounted are demonstrations of dominant and subordinate status, respectively. In this research, we aimed to test whether same-sex mounts function as dominance assertion in male golden snub-nosed monkeys (Rhinopithecus roxellana). We investigated this behavior in eight-individuals, captive all-male unit (AMU) in Shanghai wild animal park, China. Behavioral observations were conducted with a total of 1,855 mounts recorded from November, 2014 to June, 2015, during which the alpha male was replaced in the beginning of April...
January 19, 2017: American Journal of Primatology
https://www.readbyqxmd.com/read/28077570/ktcnlncdb-a-first-platform-to-investigate-lncrnas-expressed-in-human-keratoconus-and-non-keratoconus-corneas
#7
Michał W Szcześniak, Michal Kabza, Justyna A Karolak, Malgorzata Rydzanicz, Dorota M Nowak, Barbara Ginter-Matuszewska, Piotr Polakowski, Rafal Ploski, Jacek P Szaflik, Marzena Gajecka
Keratoconus (KTCN, OMIM 148300) is a degenerative eye disorder characterized by progressive stromal thinning that leads to a conical shape of the cornea, resulting in optical aberrations and even loss of visual function. The biochemical background of the disease is poorly understood, which motivated us to perform RNA-Seq experiment, aimed at better characterizing the KTCN transcriptome and identification of long non-coding RNAs (lncRNAs) that might be involved in KTCN etiology. The in silico functional studies based on predicted lncRNA:RNA base-pairings led us to recognition of a number of lncRNAs possibly regulating genes with known or plausible links to KTCN...
2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28057683/orcan-a-web-based-meta-server-for-real-time-detection-and-functional-annotation-of-orthologs
#8
Andrzej Zielezinski, Michal Dziubek, Jan Sliski, Wojciech M Karlowski
ORCAN (ORtholog sCANner) is a web-based meta-server for one-click evolutionary and functional annotation of protein sequences. The server combines information from the most popular orthology-prediction resources, including four tools and four online databases. Functional annotation utilizes five additional comparisons between the query and identified homologs, including: sequence similarity, protein domain architectures, functional motifs, Gene Ontology term assignments and a list of associated articles. Furthermore, the server uses a plurality-based rating system to evaluate the orthology relationships and to rank the reference proteins by their evolutionary and functional relevance to the query...
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27896160/neonatal-intestinal-obstruction-when-to-suspect-duplication-cyst-of-bowel-as-the-cause
#9
Rizwan Ahmad Khan, Shagufta Wahab, Imran Ghani
BACKGROUND: Duplication cyst is a rare cause of neonatal intestinal obstruction. Their most common location is the small intestine. The clinical presentation is extremely variable depending upon its size, location and type and the age of the patient and are mainly encountered during infancy or early childhood. The diagnosis is very difficult in neonates. This study was undertaken to study their presentation, diagnostic modality of choice and further management in neonatal age group. MATERIALS AND METHODS: This was a retrospective study performed at the Department of Paediatric Surgery, J ...
October 2016: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/27891354/emerging-trends-of-intentional-firearm-injuries-in-northern-india-a-study
#10
Iram Khan, Mohammad Shakeel, Jawed Ahmad Usmani, Syed Abrar Hasan
INTRODUCTION: Many developing countries are facing rise in firearm injury cases owing to communal and ethnic clashes, political violence, armed robberies and suicide causing huge economic loss to society. On the basis of intention, injuries can be categorized as intentional and unintentional or accidental injuries. Intentional injuries will include suicidal, homicidal and assault related injuries. AIM: This study was undertaken to document the trends and patterns associated with intentional firearm injuries in order to suggest ways to curb the emerging trends...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27876887/high-energy-particle-radiation-associated-oncogenic-transformation-in-normal-mice-insight-into-the-connection-between-activation-of-oncotargets-and-oncogene-addiction
#11
Natarajan Aravindan, Sheeja Aravindan, Krishnan Manickam, Mohan Natarajan
Concerns on high-energy particle radiation-induced tumorigenic transformation of normal tissue in astronauts, and in cancer patients undergoing radiotherapy, emphasizes the significance of elucidating the mechanisms involved in radiogenic transformation processes. Mostly used genetically modified or tumor-prone models are less reliable in determining human health risk in space or protracted post-treatment normal tissue toxicity. Here, in wild type C57BL/6 mice, we related the deregulation of distinctive set of tissue-specific oncotargets in major organs upon (56)Fe (600 MeV/amu; 0...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27865491/prevalence-and-risk-factors-for-extended-spectrum-%C3%AE-lactamase-or-ampc-producing-escherichia-coli-in-organic-dairy-herds-in-the-netherlands
#12
I M G A Santman-Berends, M A Gonggrijp, J J Hage, A E Heuvelink, A Velthuis, T J G M Lam, G van Schaik
Extended-spectrum β-lactamase and AmpC-producing Escherichia coli (ESBL/AmpC) are an emerging problem and are hypothesized to be associated with antimicrobial use (AMU), and more specifically with the use of third- and fourth-generation cephalosporins. Whether ESBL/AmpC also occur in organic dairy herds, which have restricted AMU, is not known. Additionally, it is unknown whether, in addition to restricted AMU, other factors in organic herd management are associated with ESBL/AmpC herd status. The aim of this study was to estimate the prevalence of ESBL/AmpC in organic dairy herds in the Netherlands...
January 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27853338/primary-enterolith-in-a-patient-with-intestinal-tuberculosis-a-case-report
#13
Mohd Habib Raza, RafiulImad Finan, Sadik Akhtar, Manzoor Ahmad
Primary enterolithiasis is a rare surgical ailment. The underlying cause is intestinal stasis. Numerous anatomical and micro environmental factors such as enteritis, incarcerated hernia, malignancy, diverticula, blind loops, and enteroenterostomy predispose to clinically significant concretions. Enterolithiasis in tuberculosis can be due to the presence of strictures, intestinal bands, or interbowel/parietal adhesions, leading to intestinal stasis. Secondary enterolithiasis is generally caused by gallstones or renal stones migrating to the gastrointestinal tract due to fistula formation...
2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27843036/acute-medical-units-the-way-to-go-a-literature-review
#14
L S van Galen, E M J Lammers, L J Schoonmade, N Alam, M H H Kramer, P W B Nanayakkara
BACKGROUND: Acute healthcare chains in the Netherlands are increasingly under pressure because of rising emergency department (ED) admissions, relative bed shortages and government policy changes. In order to improve acute patient flow and quality of care through hospitals, an acute medical unit (AMU) might be a solution, as demonstrated in the UK. However, limited information is available concerning AMUs in the Netherlands. Therefore, the aims of this study were to METHODS: A systematic literature search was performed searching 3 electronic databases: PubMed, Cochrane and EMBASE...
November 11, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27827853/antimicrobial-usage-and-antimicrobial-resistance-in-animal-production-in-southeast-asia-a-review
#15
REVIEW
Nguyen T Nhung, Nguyen V Cuong, Guy Thwaites, Juan Carrique-Mas
Southeast Asia is an area of great economic dynamism. In recent years, it has experienced a rapid rise in the levels of animal product production and consumption. The region is considered to be a hotspot for infectious diseases and antimicrobial resistance (AMR). We reviewed English-language peer-reviewed publications related to antimicrobial usage (AMU) and AMR in animal production, as well as antimicrobial residues in meat and fish from 2000 to 2016, in the region. There is a paucity of data from most countries and for most bacterial pathogens...
November 2, 2016: Antibiotics
https://www.readbyqxmd.com/read/27795294/impact-of-consultant-specialty-on-discharge-decisions-in-patients-admitted-as-medical-emergencies-to-hospitals-in-the-united-kingdom
#16
C P Subbe, Ivan Le Jeune, D Ward, S Pradhan, C Masterton-Smith
BACKGROUND: The Society for Acute Medicine's Benchmarking Audit (SAMBA) annually examines Clinical Quality Indicators (CQIs) of the care of patients admitted to UK hospitals as medical emergencies. AIM: The aim of this study is to review the impact of consultant specialty on discharge decisions in the SAMBA data-set. DESIGN AND METHODS: Prospective audit of patients admitted to acute medical units (AMUs) on 25 June 2015 to participating hospitals throughout the UK with subgroup analysis...
October 18, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27759744/variation-in-acute-medicine-units-measuring-it-understanding-it-and-reducing-it
#17
Daniel J Beckett, Elaine Thomson, Lindsay Em Reid, Robert C Lloyd
Although there are national recommendations on the function of Acute Medicine Units (AMUs), there is no single agreed best model of care. Additionally, robust data is not always available to determine whether system changes have resulted in improvement. We designed an Excel file to interface with the hospital patient management system to provide real-time data on a number of metrics including AMU length of stay (AMULOS), mortality and readmissions. This demonstrated that improving consultant continuity of care was associated with a reduction in AMULOS and reduced variation in AMULOS...
2016: Acute Medicine
https://www.readbyqxmd.com/read/27753475/multivariate-curve-resolution-alternating-least-squares-analysis-of-high-resolution-liquid-chromatography-mass-spectrometry-data
#18
Melanie M Sinanian, Daniel W Cook, Sarah C Rutan, Dayanjan S Wijesinghe
Methods such as liquid chromatography coupled with high-resolution mass spectrometry (LC-HRMS) are crucial for differentiating compounds with highly similar masses. This is a necessity when analyzing highly complex samples; however, the size of high-resolution LC-HRMS data sets can cause difficulties when applying advanced data analysis techniques. In this work, LC-HRMS analyses of known amphetamine samples and unknown bacterial lipid samples were carried out, and multivariate curve resolution-alternating least squares (MCR-ALS) was applied to the data to obtain mathematical separation of overlapped analyte signals...
November 15, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27740804/free-nano-object-ramsey-interferometry-for-large-quantum-superpositions
#19
C Wan, M Scala, G W Morley, Atm A Rahman, H Ulbricht, J Bateman, P F Barker, S Bose, M S Kim
We propose an interferometric scheme based on an untrapped nano-object subjected to gravity. The motion of the center of mass (c.m.) of the free object is coupled to its internal spin system magnetically, and a free flight scheme is developed based on coherent spin control. The wave packet of the test object, under a spin-dependent force, may then be delocalized to a macroscopic scale. A gravity induced dynamical phase (accrued solely on the spin state, and measured through a Ramsey scheme) is used to reveal the above spatially delocalized superposition of the spin-nano-object composite system that arises during our scheme...
September 30, 2016: Physical Review Letters
https://www.readbyqxmd.com/read/27709900/aerosol-chemistry-resolved-by-mass-spectrometry-insights-into-particle-growth-after-ambient-new-particle-formation
#20
Alexander L Vogel, Johannes Schneider, Christina Müller-Tautges, Thomas Klimach, Thorsten Hoffmann
Atmospheric oxidation of volatile organic compounds (VOCs) yields a large number of different organic molecules which comprise a wide range of volatility. Depending on their volatility, they can be involved in new particle formation and particle growth, thus affecting the number concentration of cloud condensation nuclei in the atmosphere. Here, we identified oxidation products of VOCs in the particle phase during a field study at a rural mountaintop station in central Germany. We used atmospheric pressure chemical ionization mass spectrometry ((-)APCI-MS) and aerosol mass spectrometry for time-resolved measurements of organic species and of the total organic aerosol (OA) mass in the size range of 0...
October 6, 2016: Environmental Science & Technology
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