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Wojciech Rosikiewicz, Michal Kabza, Jan G Kosinski, Joanna Ciomborowska-Basheer, Magdalena R Kubiak, Izabela Makalowska
Database URL: Secondary database URL:
January 1, 2017: Database: the Journal of Biological Databases and Curation
Ruth C Teh, Anne Wilson, Damith Ranasinghe, Renuka Visvanathan
OBJECTIVE: To evaluate the health information technology (HIT) compared to Fall Risk for Older Persons (FROP) tool in fall risk screening. METHODS: A HIT tool trial was conducted on the geriatric evaluation and management (GEM, n = 111) and acute medical units (AMU, n = 424). RESULTS: Health information technology and FROP scores were higher on GEM versus AMU, with no differences between people who fell and people who did not fall. Both score completion rates were similar, and their values correlated marginally (Spearman's correlation coefficient 0...
December 2017: Australasian Journal on Ageing
Shagufta Qadri, Mahboob Hasan, Kafil Akhtar
Objective: Progress in the diagnosis and treatment of childhood neoplasm in the past few decades is one of the most gratifying achievements in the field of oncology. This study was aimed to ascertain the burden (incidence and prevalence) and histopathologic features of neurogenic tumors occurring in the pediatric population. Materials and Methods: The study evaluated a total of 492 cases of pediatric tumors over a period of 8 years from 2007 to 2015, including patients of 0-12 years of age group; attending the out-patients and in-patients Department of Pediatrics and Pediatric Surgery at Jawaharlal Nehru Medical College, AMU, Aligarh, with the complaints of tumor or tumor associated sign and symptoms...
July 2017: Journal of Pediatric Neurosciences
P R Ellis, G I Walters
Background: Occupational asthma (OA) accounts for one in six cases of new-onset adult asthma. Despite this it remains under-recognized in the UK. Delayed and missed diagnoses of OA lead to poor health outcomes for workers at significant cost to the UK economy. The burden of occupational aetiology on hospital admissions with asthma is not known. Aims: To measure how frequently medical professionals consider occupational aetiology in patients presenting to secondary care with acute asthma symptoms...
November 18, 2017: Occupational Medicine
Meiru Guo, Detain Li, Yongjun Cheng, Yongjun Wang, Wenjun Sun, Xiaoqiang Pei, Meng Dong, Xuemin Sheng, Lan Zhao, Yanwu Li
With the rapid development of space technology in China, it is urgent to use mass spectrometer to detect the space environment. In this work, a space miniature magnetic sector mass spectrometer is evaluated, which consists of three subsystems: (1) physical unit, (2) electric control unit, (3) and high voltage power. It has 90° magnetic sector-field analyzer with double trajectory, in which a trajectory measurement range is from 1 to 12 amu, the other range is from 6 to 90 amu.The mass spectrometer has two work models, one is used to measure space neutral gas when the filament of mass spectrometer ion source turned on, the other is used to measure space charged ions when the filament turned off...
January 1, 2017: European Journal of Mass Spectrometry
Jung Hun Ohn, Nak Hyun Kim, Eun Sun Kim, Seon Ha Baek, Yejee Lim, Jaehyung Hur, Yun Jong Lee, Eu Suk Kim, Hak Chul Jang
A hospitalist-run acute medical unit (AMU) opened at a tertiary care hospital on August 2015 for the first time in Korea. Patients visiting the emergency department (ED) with acute medical problems are admitted to the AMU. They stay in that unit for less than 72 hours and are discharged or transferred to specialty wards if longer treatment is necessary. We reviewed 19,450 medical admissions through the ED from January 2014 to September 2016. The median length of stay (LOS) significantly decreased from 10.0 days (interquartile range [IQR], 5...
December 2017: Journal of Korean Medical Science
S W Miller, B D Prince, R J Bemish
A combined experimental and modeling effort is undertaken to assess a detection system composed of an orthogonal extraction time-of-flight (TOF) mass spectrometer coupled to a continuous ion source emitting an ion beam with kinetic energy of several hundred eV. The continuous ion source comprises an electrospray capillary system employing an undiluted ionic liquid emitting directly into vacuum. The resulting ion beam consists of ions with kinetic energy distributions of width greater than a hundred of eV and mass-to-charge (m/q) ratios ranging from 111 to 500 000 amu/q...
October 2017: Review of Scientific Instruments
Raina J Olsen, Andrew K Gillespie, Cristian I Contescu, Jonathan W Taylor, Peter Pfeifer, James R Morris
Here we report a phase transition in H2 adsorbed in a locally graphitic Saran carbon with subnanometer pores 0.5-0.65 nm in width, in which two layers of hydrogen can just barely squeeze, provided they pack tightly. The phase transition is observed at 75 K, temperatures far higher than other systems in which an adsorbent is known to increase phase transition temperatures: for instance, H2 melts at 14 K in the bulk, but at 20 K on graphite because the solid H2 is stabilized by the surface structure. Here we observe a transition at 75 K and 77-200 bar: from a low-temperature, low-density phase to a high-temperature, higher density phase...
November 7, 2017: ACS Nano
Achilleas Floudas, Christopher D Cluxton, Julia Fahel, Adnan R Khan, Sean P Saunders, Sylvie Amu, Antonio Alcami, Padraic G Fallon
The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune system. Herein, we characterise the S. mansoni adult male worm secretome and identify 111 proteins, including 7 vaccine candidates and several molecules with potential immunomodulatory activity. Amongst the molecules present in the secretome, a 17-19kDa protein analogous to human cyclophilin A was identified...
October 2017: PLoS Neglected Tropical Diseases
Wojciech Rosikiewicz, Yutaka Suzuki, Izabela Makalowska
Gene overlap plays various regulatory functions on transcriptional and post-transcriptional levels. Most current studies focus on protein-coding genes overlapping with non-protein-coding counterparts, the so called natural antisense transcripts. Considerably less is known about the role of gene overlap in the case of two protein-coding genes. Here, we provide OverGeneDB, a database of human and mouse 5' end protein-coding overlapping genes. The database contains 582 human and 113 mouse gene pairs that are transcribed using overlapping promoters in at least one analyzed library...
October 23, 2017: Nucleic Acids Research
Wei Gao, James B McAlpine, Mary P Choules, José G Napolitano, David C Lankin, Charlotte Simmler, Ngoc Anh Ho, Hanki Lee, Joo-Won Suh, Ian W Burton, Sanghyun Cho, Scott G Franzblau, Shao-Nong Chen, Guido F Pauli
This report describes an approach using (1)H NMR iterative full-spin analysis (HiFSA) to extract definitive structural information on unknown peptides from 1D (1)H NMR data. By comparing the experimental data and HiFSA fingerprint of a known analogue, it is possible to isolate the characteristic (1)H subspectrum of the different amino acids and, thus, elucidate the structure of the peptide. To illustrate this methodology, a comprehensive analysis of five new anti-Mycobacterium tuberculosis peptides (2-6), all analogues of ecumicin (1), was carried out...
October 27, 2017: Journal of Natural Products
L E M Reid, A J F Crookshanks, M C Jones, Z J Morrison, N I Lone, C J Weir
The majority of medical patients presenting to hospital in the UK are cared for in acute medical units (AMUs). Such units are also increasingly present internationally. Care delivery varies across units: this review aims to examine the evidence for how best to deliver AMU care.Six electronic databases and grey literature were searched. Inclusion criteria comprised interventions applied to undifferentiated patients in AMU settings. All studies were quality assessed. A narrative approach was undertaken.Nine studies, all conducted in the UK or Ireland, evaluated 1...
August 4, 2017: QJM: Monthly Journal of the Association of Physicians
Anna E Hurtley, Elizabeth A Stone, Anthony J Metrano, Scott J Miller
Diarylmethylamido bis(phenols) have been subjected to peptide-catalyzed, enantioselective bromination reactions. Desymmetrization of compounds in this class has been achieved such that enantioenriched products may be isolated with up to 97:3 er. Mechanistically, the observed enantioselectivity was shown to be primarily a function of differential functionalization of enantiotopic arenes, although additional studies unveiled a contribution from secondary kinetic resolution of the product (to afford the symmetrical dibromide) under the reaction conditions...
October 20, 2017: Journal of Organic Chemistry
R S Nannan Panday, T C Minderhoud, N Alam, P W B Nanayakkara
BACKGROUND: A wide array of early warning scores (EWS) have been developed and are used in different settings to detect which patients are at risk of deterioration. The aim of this review is to provide an overview of studies conducted on the value of EWS on predicting intensive care (ICU) admission and mortality in the emergency department (ED) and acute medical unit (AMU). METHODS: A literature search was conducted in the bibliographic databases PubMed and EMBASE, from inception to April 2017...
October 6, 2017: European Journal of Internal Medicine
Diego B Nobrega, Jeroen De Buck, S Ali Naqvi, Gang Liu, Sohail Naushad, Vineet Saini, Herman W Barkema
Assessment of antimicrobial use (AMU) is vital for interpreting the origin of changes in antimicrobial resistance (AMR). The objectives of the present study were to estimate the association between AMU determined using on-farm treatment records (TR) and inventory of empty drug containers (INV). Herds were selected to represent Canadian dairy farms. Producers were asked to record animal health events and treatments on a standard General Health Event form. For inventory data, 40-L receptacles were placed at various locations considered convenient to deposit all empty drug containers...
October 4, 2017: Journal of Dairy Science
Maarten F Heringa, Jay Gates Slowik, Maximilian Goldmann, Ruth Signorell, Patrick Hemberger, Andras Bodi
The valence threshold photoionization of oleic acid has been studied using synchrotron VUV radiation and imaging photoelectron photoion coincidence (iPEPICO) spectroscopy. An oleic acid aerosol beam was impacted on a copper thermodesorber, heated to 130 °C, to evaporate the particles quantitatively. Upon threshold photoionization, oleic acid produces the intact parent ion first, followed by dehydration at higher energies. Starting at ca. 10 eV, a large number of fragment ions slowly rise suggesting several fragmentation coordinates with quasi-degenerate activation energies...
October 7, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
J A Álvarez, C Ávila, P Otter, R Kilian, D Istenič, M Rolletschek, P Molle, N Khalil, I Ameršek, V K Mishra, C Jorgensen, A Garfi, P Carvalho, H Brix, C A Arias
SWINGS was a cooperation project between the European Union and India, aiming at implementing state of the art low-cost technologies for the treatment and reuse of domestic wastewater in rural areas of India. The largest wastewater treatment plant consists of a high-rate anaerobic system, followed by vertical and horizontal subsurface flow constructed wetlands with a treatment area of around 1,900 m(2) and a final step consisting of solar-driven anodic oxidation (AO) and ultraviolet (UV) disinfection units allowing direct reuse of the treated water...
September 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Pengkun Ma, Peng Zhang, Jinian Shu, Bo Yang, Haixu Zhang
To further explore the composition and distribution of secondary organic aerosol (SOA) components from the photo-oxidation of light aromatic precursors (toluene, m-xylene, and 1,3,5-trimethylbenzene (1,3,5-TMB)) and idling gasoline exhaust, a vacuum ultraviolet photoionization mass spectrometer (VUV-PIMS) was employed. Peaks of the molecular ions of the SOA components with minimum molecular fragmentation were clearly observed from the mass spectra of SOA, through the application of soft ionization methods in VUV-PIMS...
September 13, 2017: Environmental Pollution
Qamar Zia, Asim Azhar, Shadab Ahmad, Mohammad Afsar, Ziaul Hasan, Mohammad Owais, Mahfooz Alam, Shabab Akbar, Magdah Ganash, Ghulam Md Ashraf, Swaleha Zubair, Gjumrakch Aliev
BACKGROUND: For design of a subunit vaccine for tuberculosis, identification of antigenic T-cell epitope is of utmost importance. Several MHC prediction server are available that can accurately predict antigenic peptide of variable lengths. However, peptides predicted from one server not necessarily are predicted form another server, thus creating a confusing situation for scientists to choose a best epitope. METHOD: Keeping the above problem in mind, we developed a comprehensive database of peptides of Mycobacterial proteins...
September 14, 2017: Current Pharmaceutical Biotechnology
Xian Cao, Matthew A Tarr
Aldehyde and ketone photoproducts were observed in the aqueous phase under oil exposed to simulated sunlight by using 2,4-dinitrophenylhydrazine (DNPH) derivatization and electrospray ionization-tandem mass spectrometry (ESI-MS/MS). Oil samples were spread over seawater in a jacketed beaker held at 27.0 °C and exposed to simulated sunlight. The aqueous phase was collected after irradiation and derivatized with DNPH, which selectively reacts with aldehydes and ketones. The derivatized hydrazones (aldehyde- and ketone-DNPH derivatives) were washed and enriched with a solid-phase extraction cartridge prior to analysis by ESI-MS/MS in negative ion mode...
October 17, 2017: Environmental Science & Technology
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