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embryo IVF oocyte implantation

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https://www.readbyqxmd.com/read/27915039/uterine-immune-profiling-for-increasing-live-birth-rate-a-one-to-one-matched-cohort-study
#1
Nathalie Lédée, Laura Prat-Ellenberg, Lucie Chevrier, Richard Balet, Cynthia Simon, Clarisse Lenoble, Elie El Irani, Dominique Bouret, Guy Cassuto, Dominique Vitoux, Katia Vezmar, Armand Bensussan, Gérard Chaouat, Marie Petitbarat
BACKGROUND: Embryo implantation remains the main limiting factor in IVF/ICSI program. Endometrial immune remodeling events begin before implantation and are a vital process for pregnancy, preparing future maternal immune tolerance and regulating the placentation process. METHODS: Between 2012 and 2014, 193 patients (analyzed group) enrolled in our IVF program benefitted of an endometrial immune profiling to determine if their uterus was immunologically ready to accept an embryo and, if not, the specific immune mechanisms involved...
November 24, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27865446/the-use-of-utrogestan-during-controlled-ovarian-hyperstimulation-in-normally-ovulating-women-undergoing-in%C3%A2-vitro-fertilization-or-intracytoplasmic-sperm-injection-treatments-in-combination-with-a-freeze-all-strategy-a-randomized-controlled-dose-finding-study
#2
Xiuxian Zhu, Hongjuan Ye, Yonglun Fu
OBJECTIVE: To compare the clinical characteristics in a Utrogestan and hMG protocol with the use of different doses of Utrogestan in normally ovulating women undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatments. DESIGN: Prospective controlled study. SETTING: Tertiary-care academic medical center. PATIENT(S): A total of 150 infertile patients undergoing IVF/ICSI treatments. INTERVENTION(S): Utrogestan and hMG were administered simultaneously beginning on cycle day 3...
November 16, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27831635/short-gonadotropin-releasing-hormone-agonist-versus-flexible-antagonist-versus-clomiphene-citrate-regimens-in-poor-responders-undergoing-in-vitro-fertilization-a-randomized-controlled-trial
#3
M Schimberni, F Ciardo, M Schimberni, A Giallonardo, V De Pratti, M Sbracia
OBJECTIVE: Poor responders represent a frustrating condition for couples undergoing IVF and clinicians, and their treatment remains disputed. To assess the efficacy and the most suitable protocol, we conducted a randomized controlled trial comparing three different protocols of ovarian stimulation in poor responder women: clomiphene citrate (CC) plus a high dose of gonadotropins and GnRH antagonist, flexible GnRH antagonist protocol and a short GnRH agonist protocol. PATIENTS AND METHODS: Between July 2014 and December 2015 we enrolled 250 poor responders in a previous IVF cycle at least 3 months before...
October 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27824942/identifying-maternal-constraints-on-fetal-growth-and-subsequent-perinatal-outcomes-using-a-multiple-embryo-implantation-model
#4
Nigel Pereira, Tyler Cozzubbo, Stephanie Cheung, Zev Rosenwaks, Gianpiero D Palermo, Queenie V Neri
INTRODUCTION: Although the majority of singleton births after in vitro fertilization (IVF) are uncomplicated, studies have suggested that IVF pregnancies may be independently associated with low birth weight (LBW), preterm birth (PTB), and perinatal mortality. These outcomes complicate multiple gestations as expected, but have also been reported in singletons. A multiple embryo implantation model allows for assessment of the early in utero environment, and therefore, assessment of any maternal constraints on developing fetuses...
2016: PloS One
https://www.readbyqxmd.com/read/27817036/freeze-all-cycle-for-all-normal-responders
#5
Matheus Roque, Marcello Valle, Fernando Guimarães, Marcos Sampaio, Selmo Geber
PURPOSE: The purpose of this study is to evaluate the freeze-all strategy in subgroups of normal responders, to assess whether this strategy is beneficial regardless of ovarian response, and to evaluate the possibility of implementing an individualized embryo transfer (iET) based on ovarian response. METHODS: This was an observational, cohort study performed in a private IVF center. A total of 938 IVF cycles were included in this study. The patients were submitted to controlled ovarian stimulation (COS) with a gonadotropin-releasing hormone (GnRH) antagonist protocol and a cleavage-stage day 3 embryo transfer...
November 5, 2016: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/27808664/dynamics-of-the-development-of-multiple-follicles-by-early-versus-late-hcg-administration-in-art-program
#6
Maddalena Falagario, Paolo Trerotoli, Annarosa Chincoli, Isabella Cobuzzi, Margherita P Vacca, Doriana Falagario, Claudia Nardelli, Raffaella Depalo
OBJECTIVE: To evaluate, in patients stimulated with recombinant FSH and GnRH antagonists, whether triggering the final maturation of oocytes affects IVF outcomes. STUDY DESIGN: Five hundred and six IVF procedures were divided into three groups according to the timing of hCG administration: when at least 2 follicles reached the diameter of 17 mm, at least 2 follicles reached 18 mm and at least 2 follicles reached 20 mm. The main outcome was the number of mature oocyte that was the dependent variable of a multivariate model whose independents were, age, AFC, hCG timing, E2 levels at hCG day, number of follicles in different categories of dimension...
November 3, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27762465/ultrasound-sclerotherapy-pretreatment-could-obtain-a-similar-effect-to-surgical-intervention-on-improving-the-outcomes-of-in-vitro-fertilization-for-patients-with-hydrosalpinx
#7
Xiao-Min Song, Hong Jiang, Wen-Xiang Zhang, Yun Zhou, Feng Ni, Xue-Mei Wang
AIM: The aim of this study was to compare the clinical outcomes of in vitro fertilization (IVF) for patients with hydrosalpinx between ultrasound sclerotherapy and surgical intervention. METHODS: The data of 482 IVF/intracytoplasmic sperm injection (ICSI) cycles were divided into three groups according to different intervention protocols before IVF/ICSI. Group A included 265 cycles in which ultrasound sclerotherapy pretreatment was carried out before controlled ovarian hyperstimulation...
October 20, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27752179/-effect-of-catheter-choice-during-embryo-transfer-on-the-clinical-outcome-of-in-vitro-fertilization-embryo-transfer
#8
X L Ren, P Liu, Y Lian, J Huang, X Y Zheng, Y J Zhu, J Qiao
OBJECTIVE: To compare two flexible embryo catheters and determine whether clinical outcome differs in the in vitro fertilization-embryo transfer (IVF-ET) cycles. METHODS: This prospective control study was conducted by one doctor between July 2012 and November 2013. In the study, 2 064 patients undergoing fresh embryo transfer by using IVF-ET/intracytoplasmic sperm injection (ICSI)-ET in Reproductive Medical Center of Peking University Third Hospital were recruited...
October 18, 2016: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/27743693/oocytes-with-smooth-endoplasmic-reticulum-clusters-originate-blastocysts-with-impaired-implantation-potential
#9
Amanda Souza Setti, Rita Cássia Sávio Figueira, Daniela Paes de Almeida Ferreira Braga, Matheus de Castro Azevedo, Assumpto Iaconelli, Edson Borges
OBJECTIVE: To study whether embryos derived from oocytes presenting a smooth endoplasmic reticulum cluster (SERC) are less likely to develop into blastocysts and implant. DESIGN: Transversal study. SETTING: Private university-affiliated in vitro fertilization (IVF) center. PATIENT(S): Total of 7,609 oocytes obtained from 743 intracytoplasmic sperm injection (ICSI) cycles. INTERVENTION(S): Oocytes split between the SERC-positive cycles (with at least one SERC-positive oocyte) and the SERC-negative cycles (only oocytes free of SERC)...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27738657/gnrh-agonist-trigger-versus-hcg-trigger-in-gnrh-antagonist-in-ivf-icsi-cycles-a-review-article
#10
REVIEW
Ashraf Alyasin, Shayesteh Mehdinejadiani, Marzieh Ghasemi
Routinely, a bolus of 5.000-10.000 IU human chorionic gonadotropin (hCG) is used for the final follicular maturation and ovulation as a standard method. HCG has the same effect of luteinizing hormone (LH) with long half-life. It has the long lutheotrophic effect which increases the risk of ovarian hyper stimulation syndrome (OHSS). Recently, gonadotropin-releasing hormone agonist (GnRH-a) trigger has been used for the induction of final follicular maturation and ovulation with the aim of reducing the OHSS risk...
September 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/27680029/intrauterine-administration-of-hcg-immediately-after-oocyte-retrieval-and-the-outcome-of-icsi-a-randomized-controlled-trial
#11
N Navali, A Gassemzadeh, L Farzadi, S Abdollahi, M Nouri, K Hamdi, F Mallah, F Jalilvand
STUDY QUESTION: Does the intrauterine administration of hCG immediately after oocyte retrieval in antagonist cycles with ICSI and fresh embryo transfer (ET) influence the implantation rate or chemical and clinical pregnancy rates? SUMMARY ANSWER: The intrauterine administration of hCG after oocyte retrieval increases the implantation rate and chemical and clinical pregnancy rates. WHAT IS KNOWN ALREADY: Over half of IVF/ICSI cycles fail due to implantation failure...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27665252/in-vitro-fertilization-outcomes-after-ablation-of-endometriomas-using-plasma-energy-a-retrospective-case-control-study
#12
I Motte, H Roman, B Clavier, F Jumeau, I Chanavaz-Lacheray, M Letailleur, B Darwish, N Rives
OBJECTIVE: Ovarian endometrioma ablation using plasma energy appears to be a valuable alternative to cystectomy, because it could spare underlying ovarian parenchyma resulting in high spontaneous and overall pregnancy rates. After initial postoperative decrease, anti-mullerian hormone (AMH) level progressively increases several months after ablation. The aim of our study was to assess the outcomes of in vitro fertilization (IVF) in women managed for ovarian endometriomas by ablation using plasma energy, when compared to those in women free of endometriosis...
October 2016: Gynécologie, Obstétrique & Fertilité
https://www.readbyqxmd.com/read/27651724/a-novel-approach-using-a-minimal-number-of-injections-during-the-ivf-icsi-cycle-luteal-half-dose-depot-gnrh-agonist-following-corifollitropin-alfa-versus-the-corifollitropin-alfa-with-a-gnrh-antagonist-cycle
#13
Bülent Haydardedeoğlu, Esra Bulgan Kılıçdağ
OBJECTIVE: Corifollitropin alfa is a good choice for assisted reproductive technology (ART) cycles because fewer injections are needed than with other agents. In this retrospective cohort, we analyzed luteal injected half-dose depot gonadotropin hormone-releasing hormone (GnRH) agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist. MATERIAL AND METHODS: In this retrospective cohort, we analyzed luteal injected half-dose depot GnRH agonist cycles in women who received corifollitropin alfa and those who underwent a conventional corifollitropin alfa cycle with a GnRH antagonist at the Division of Reproductive Endocrinology and IVF Unit, Obstetrics and Gynecology Department, Başkent University School of Medicine, Adana, Turkey, from March 2014 to August 2015...
2016: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/27628754/novel-embryo-selection-techniques-to-increase-embryo-implantation-in-ivf-attempts
#14
George Α Sigalos, Olga Triantafyllidou, Nikos F Vlahos
PURPOSE: The final success of an IVF attempt depends on several steps and decisions taken during the ovarian stimulation, the oocyte retrieval, the embryo culture and the embryo transfer. The final selection of the embryos most likely to implant is the final step in this process and the responsibility of the lab. Apart from strict morphologic criteria that historically have been used in embryo selection, additional information on genetic, metabolomic and morphokinetic characteristics of the embryo is recently combined to morphology to select the embryo most likely to produce a pregnancy...
September 15, 2016: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27619770/hatching-status-before-embryo-transfer-is-not-correlated-with-implantation-rate-in-chromosomally-screened-blastocysts
#15
Jorge Rodriguez-Purata, Julian Gingold, Joseph Lee, Michael Whitehouse, Richard Slifkin, Christine Briton-Jones, Alan Copperman, Benjamin Sandler
STUDY QUESTION: Do the reproductive outcomes from the transfer of fully hatched (FH) blastocysts differ from those of not fully hatched (NFH) blastocysts? SUMMARY ANSWER: Biochemical pregnancy rate (BPR), implantation rate (IR), live birth rate (LBR) and early pregnancy loss (EPL) rate are similar in FH and NFH single euploid blastocyst embryo transfers. WHAT IS KNOWN ALREADY: The use of extended culture and PGS often leads to transfer of an embryo that is well developed and frequently FH from the zona pellucida...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27575500/basal-follicle-stimulating-hormone-level-correlated-to-age-is-a-good-prognostic-criterion-for-the-outcome-of-intracytoplasmic-sperm-microinjection
#16
Moez Kdous, Ghaya Merdassi, Fethi Zhioua, Hanène Elloumi, Khadija Kacem, Amel Zhioua
BACKGROUND: Age and increased FSH serum level in women are prognosis criteriae associated with decreased fertility. OBJECTIVE: The aim of this study was to investigate whether age-specific FSH concentration can be a predictor of the outcome of ovarian stimulation in women undergoing IVF. METHODS: A total of 676 women undergoing their first IVF cycle over a 3-year period were included in this retrospective cohort study. Patients were grouped according to age (< or ≥  38 years), and within each age range, patients were grouped into bFSH quartiles (< or ≥  9...
March 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27566220/hysteroscopic-polypectomy-without-cycle-cancellation-in-ivf-icsi-cycles-a-cross-sectional-study
#17
Firouzeh Ghaffari, Arezoo Arabipoor, Narges Bagheri Lankarani, Fatemeh Hosseini, Akram Bahmanabadi
OBJECTIVE(S): To evaluate the effect of hysteroscopic polypectomy during ovarian stimulation phase on in vitro fertilization and/or intracytoplasmic sperm injection (IVF/ICSI) cycles outcomes. STUDY DESIGN: This cross sectional study was performed in female infertility department of Royan Institute from January 2011 to December 2013. In total, 160 patients who were diagnosed incidentally polyp/polyps less than 20mm during the stimulation phase for oocyte recoveries were recruited; of these, fifty eight cases underwent hysteroscopic polypectomy without cycle cancellation non-randomly...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27530063/automatic-time-lapse-instrument-is-superior-to-single-point-morphology-observation-for-selecting-viable-embryos-retrospective-study-in-oocyte-donation
#18
Belén Aparicio-Ruiz, Natalia Basile, Sonia Pérez Albalá, Fernando Bronet, José Remohí, Marcos Meseguer
OBJECTIVE: To correlate the different categories provided by a commercial diagnostic test with blastocyst formation, quality, implantation potential, and ongoing pregnancy (OPR) for the purpose of validating the automatic annotations and the classification algorithm. DESIGN: Observational, retrospective, multicenter cohort study. SETTING: University-affiliated private IVF center. PATIENT(S): A total of 3,002 embryos, including 521 transferred embryos with known implantation, from 626 IVF cycles that were incubated in a conventional incubator and monitored with an automatic time-lapse test...
August 13, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27523926/pregnancy-derived-from-human-zygote-pronuclear-transfer-in-a-patient-who-had-arrested-embryos-after-ivf
#19
John Zhang, Guanglun Zhuang, Yong Zeng, Jamie Grifo, Carlo Acosta, Yimin Shu, Hui Liu
Nuclear transfer of an oocyte into the cytoplasm of another enucleated oocyte has shown that embryogenesis and implantation are influenced by cytoplasmic factors. We report a case of a 30-year-old nulligravida woman who had two failed IVF cycles characterized by all her embryos arresting at the two-cell stage and ultimately had pronuclear transfer using donor oocytes. After her third IVF cycle, eight out of 12 patient oocytes and 12 out of 15 donor oocytes were fertilized. The patient's pronuclei were transferred subzonally into an enucleated donor cytoplasm resulting in seven reconstructed zygotes...
October 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27515175/successful-in-vitro-fertilization-and-generation-of-transgenics-in-black-and-tan-brachyury-btbr-mice
#20
Mieke Baan, Kathleen J Krentz, Danielle A Fontaine, Dawn Belt Davis
The Black and Tan Brachyury (BTBR) mouse strain is a valuable model for the study of long-term complications from obesity-induced type 2 diabetes mellitus and autism spectrum disorder. Due to technical difficulties with assisted reproduction, genetically modified animals on this background have previously been generated through extensive backcrossing, which is expensive and time-consuming. We successfully generated two separate transgenic mouse lines after direct zygote microinjection into this background strain...
December 2016: Transgenic Research
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