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embryo IVF oocyte implantation

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https://www.readbyqxmd.com/read/28343757/clinical-utility-of-newly-developed-highly-purified-human-menopausal-gonadotrophins-a-randomized-controlled-trial
#1
Hwa Seon Koo, Hwang Kwon, Doo Seok Choi, Song Han, Jung Youn Seo, Kwang Moon Yang
The aim of this study was to evaluate the safety and efficacy of IVF-M HP, a newly developed highly purified human menopausal gonadotrophin preparation, for ovarian stimulation in women with infertility undergoing IVF, intracytoplasmic sperm injection (IVF-ICSI) and embryo transfer using a GnRH antagonist protocol. This was a multicentre, randomized, active-controlled, parallel design, open-label, non-inferiority clinical study. Of the 112 patients randomized for treatment using the GnRH antagonist protocol, 111 were treated...
March 1, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28333033/freeze-all-cycle-in-reproductive-medicine-current-perspectives
#2
Matheus Roque, Marcello Valle, Alessandra Kostolias, Marcos Sampaio, Selmo Geber
The freeze-all strategy has emerged as an alternative to fresh embryo transfer (ET) during in vitro fertilization (IVF) cycles. Although fresh ET is the norm during assisted reproductive therapies (ART), there are many concerns about the possible adverse effects of controlled ovarian stimulation (COS) over the endometrium. The supra-physiologic hormonal levels that occur during a conventional COS are associated with modifications in the peri-implantation endometrium, which may be related to a decrease in pregnancy rates and poorer obstetric and perinatal outcomes when comparing fresh to frozen-thawed embryo transfers...
February 1, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/28329721/how-many-embryos-should-be-transferred-a-validated-score-to-predict-ongoing-implantation-rate
#3
Nicolas Gatimel, Melissa Ladj, Carole Teston, Florence Lesourd, Carole Fajau, Clémentine Cohade, Jean Parinaud, Roger D Léandri
OBJECTIVE: To developed a prognostic score to predict ongoing implantation rate according to clinical and biological parameters and to choose the number of embryos to be transferred in patients undergoing IVF/ICSI. STUDY DESIGN: The transfer score was established using multivariate analysis of biological and clinical parameters in 3211 fresh embryo transfers in a retrospective study. Then we validated the score in 694 fresh embryo transfers in a prospective study...
March 8, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28328856/the-influence-of-different-growth-hormone-addition-protocols-to-poor-ovarian-responders-on-clinical-outcomes-in-controlled-ovary-stimulation-cycles-a-systematic-review-and-meta-analysis
#4
Xue-Li Li, Li Wang, Fang Lv, Xia-Man Huang, Li-Ping Wang, Yu Pan, Xiao-Mei Zhang
BACKGROUND: Growth hormone (GH) is used as an adjuvant therapy in in vitro fertilization and embryo transfer (IVF-ET) for poor ovarian responders, but findings for its effects on outcomes of IVF have been conflicting. The aim of the study was to compare IVF-ET outcomes among women with poor ovarian responders, and find which subgroup can benefit from the GH addition. METHODS: We searched the databases, using the terms "growth hormone," "GH," "IVF," "in vitro fertilization...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28322538/controlled-ovarian-stimulation-and-triggers-in-in-vitro-fertilization-protocol-personalization-key-to-optimize-outcomes
#5
Jacqueline Y Maher, Mindy S Christianson
The past four decades have delivered many advancements to improve in vitro fertilization (IVF) outcomes. These include a delicate balance of controlled ovarian hyperstimulation (COH) without causing ovarian hyperstimulation syndrome (OHSS), a safe oocyte retrieval, fertilization and embryo culture, endometrial growth and receptivity to promote implantation, and luteal support to maintain the pregnancy. Contemporary IVF practice includes both the classic COH protocols as well as protocols for poor responders and those for specific patient populations...
March 21, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28321529/the-cumulative-dose-of-gonadotropins-used-for-controlled-ovarian-stimulation-does-not-influence-the-odds-of-embryonic-aneuploidy-in-patients-with-normal-ovarian-response
#6
Lucky Sekhon, Kathryn Shaia, Anthony Santistevan, Karen Hunter Cohn, Joseph A Lee, Piraye Yurttas Beim, Alan B Copperman
OBJECTIVE: Controlled ovarian hyperstimulation (COH) promotes multifollicular growth, increasing the chance of obtaining euploid embryos that will successfully implant. Whether aneuploidy is increased from COH with exogenous gonadotropins interfering with natural selection of dominant follicles is a concern. This study evaluates the association between gonadotropin exposure and aneuploidy. METHODS: This is a retrospective cohort study of 828 patients that underwent 1122 IVF cycles involving controlled ovarian stimulation and trophectoderm biopsy for preimplantation genetic screening (PGS), from 2010 to 2015...
March 20, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28293051/the-effect-of-four-different-gonadotropin-protocols-on-oocyte-and-embryo-quality-and-pregnancy-outcomes-in-ivf-icsi-cycles-a-randomized-controlled-trial
#7
Mohammad Ebrahim Parsanezhad, Bahia Namavar Jahromi, Solmaz Rezaee, Leila Kooshesh, Sanaz Alaee
BACKGROUND: Despite the large number of papers published on the efficiency of different exogenous gonadotropins, no confirmed protocol exists. Therefore, the aim of the present study was to compare the efficacy of 4 exogenous gonadotropins in IVF/ICSI cycles. METHODS: This study, performed from January 2014 to May 2014, recruited 160 women referred to Ghadir Mother and Child Hospital and Dena Hospital, Shiraz, Iran. The patients underwent standard downregulation and were randomly divided into 4 groups of A, B, C, and D and were administered hMG, hFSH, rFSH, and combined sequential hFSH/rFSH, respectively...
January 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28277137/the-decline-in-serum-estradiol-on-the-second-day-after-oocyte-retrieval-affects-the-outcome-of-ivf-icsi-et-treatment-in-high-ovarian-responders
#8
Xueyan Bai, Yang Zhang, Shan Liu, Danni Qu, Hui Su, Haiying Ren, Yuan Li
OBJECTIVE: To investigate the predictive value of the decline in serum estradiol on the second day after oocyte retrieval on the outcomes of in vitro fertilization (IVF) or intra-cytoplasmic sperm injection and embryo transfer (ICSI-ET) among high ovarian responders. DESIGN: Retrospective single-center cohort study. SETTING: Tertiary-care, university-affiliated teaching hospital. Patients Women aged 20-45 years undergoing assisted reproduction treatment from June 2014 to December 2015...
February 21, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28244019/effect-of-metformin-and-oral-contraceptives-on-polycystic-ovary-syndrome-and-ivf-cycles
#9
M N Kalem, Z Kalem, T Gurgan
AIM: The aim of this study is to investigate the effect of metformin and/or OC added to the treatment of PCOS patients at our clinic on IVF outcome. MATERIALS AND METHODS: This study is a retrospective study that assesses the data of PCOS patients who received IVF between 2005 and 2015 at a private IVF center. The study included 496 PCOS cases aged between 24 and 40. Participants diagnosed with PCOS were divided into 4 groups according to the use of metformin and OC prior to the IVF cycle: 11...
February 27, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28162937/effect-of-progesterone-elevation-in-follicular-phase-of-ivf-cycles-on-the-endometrial-receptivity
#10
REVIEW
B Lawrenz, H M Fatemi
The premature rise of progesterone during the late follicular phase in stimulated IVF cycles is a frequent event, and emerging evidence shows that premature progesterone rise does negatively affect the outcome of assisted reproductive techniques. The effect of elevated peripheral progesterone levels in the late follicular phase seems to be on the endometrium and the window of implantation, which may lead to asynchrony between the endometrium and the developing embryo. In stimulated cycles, endometrial maturation is advanced on the day of oocyte retrieval, and patients with a progesterone level above 1...
January 24, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28127436/sperm-quality-and-paternal-age-effect-on-blastocyst-formation-and-pregnancy-rates
#11
Aurélie Chapuis, Anna Gala, Alice Ferrières-Hoa, Tiffany Mullet, Sophie Bringer-Deutsch, Emmanuelle Vintejoux, Antoine Torre, Samir Hamamah
BACKGROUND: Several studies suggest a decrease in sperm quality in men in the last decades. Therefore, the aim of this work was to assess the influence of male factors (sperm quality and paternal age) on the outcomes of conventional in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). METHODS: This retrospective study included all couples who underwent IVF or ICSI at Montpellier University Hospital, France, between 1 January 2010 and 31 December 2015...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28100115/paternal-age-is-not-associated-with-pregnancy-outcomes-after-single-thawed-euploid-blastocyst-transfer
#12
Ashley W Tiegs, Nidhee M Sachdev, Jamie A Grifo, David H McCulloh, Frederick Licciardi
Although controversial, increasing paternal age has been shown to negatively affect assisted reproductive technology (ART) outcomes and success rates. Most studies investigating the effect of paternal age on ART outcomes use a donor oocyte model to minimize maternal aneuploidy contribution. This study sought to determine whether increasing paternal age is associated with adverse in vitro fertilization (IVF) outcomes when aneuploidy is minimized using preimplantation genetic screening. There were 573 single thawed euploid embryo transfers from 473 patients undergoing oocyte donor and autologous IVF cycles...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28090464/the-efficacy-of-intrauterine-instillation-of-granulocyte-colony-stimulating-factor-in-infertile-women-with-a-thin-endometrium-a-pilot-study
#13
Dayong Lee, Jae Dong Jo, Seul Ki Kim, Byung Chul Jee, Seok Hyun Kim
OBJECTIVE: The study aimed to investigate the efficacy of intrauterine instillation of granulocyte colony-stimulating factor (G-CSF) on the day of ovulation triggering or oocyte retrieval in infertile women with a thin endometrium. METHODS: Fifty women whose endometrial thickness (EMT) was ≤8 mm at the time of triggering during at least one previous in vitro fertilization (IVF) cycle and an index IVF cycle were selected. On the day of triggering (n=12) or oocyte retrieval (n=38), 300 µg of G-CSF was instilled into the uterine cavity...
December 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/28089717/persistent-organic-pollutants-pops-in-human-follicular-fluid-and-in-vitro-fertilization-outcomes-a-pilot-study
#14
Michael S Bloom, Victor Y Fujimoto, Robin Storm, Li Zhang, Celeste D Butts, Diana Sollohub, Robert L Jansing
Persistent organic pollutants (POPs) are ubiquitously distributed among the U.S. population and adversely impact human reproduction. These compounds have been detected in human ovarian follicular fluid (FF), where they directly contact a developing oocyte. As a pilot investigation, we measured 43 polychlorinated biphenyl (PCB) congeners, p,p'-dichlorodiphenyltrichloroethane (DDT), and its persistent metabolite p,p'-dichlorodiphenyldichloroethylene (DDE) in residual FF collected from 32 women undergoing in vitro fertilization (IVF)...
January 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28077604/the-mitochondrial-dna-content-of-cumulus-granulosa-cells-is-linked-to-embryo-quality
#15
V Desquiret-Dumas, A Clément, V Seegers, L Boucret, V Ferré-L'Hotellier, P E Bouet, P Descamps, V Procaccio, P Reynier, P May-Panloup
STUDY QUESTION: Could the mitochondrial DNA (mtDNA) content of cumulus granulosa cells (CGCs) be related to oocyte competence? SUMMARY ANSWER: The quality of embryos obtained during IVF procedures appears to be linked to mtDNA copy numbers in the CGCs. WHAT IS KNOWN ALREADY: Oocyte quality is linked to oocyte mtDNA content in the human and other species, and the mtDNA copy number of the oocyte is related to that of the corresponding CGCs. Moreover, the quantification of CGC mtDNA has recently been proposed as a biomarker of embryo viability...
January 6, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28073982/urinary-triclosan-concentrations-and-early-outcomes-of-in-vitro-fertilization-embryo-transfer
#16
Rui Hua, Yao Zhou, Biao Wu, Zhongwei Huang, Yongtong Zhu, Yali Song, Yanhong Yu, Hong Li, Song Quan
Triclosan (TCS) exists ubiquitously in the environment. Several in vitro and in vivo studies have demonstrated that TCS exerts endocrine disruptive effects on reproduction, but data from human populations are limited and conflicting. The objective of our study was to investigate whether high urinary TCS concentration is adversely associated with early reproductive outcomes in women undergoing in vitro fertilization-embryo transfer (IVF-ET). This prospective cohort study was conducted from September 2015 to June 2016, including 156 infertile women undergoing their first IVF-ET cycle...
March 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28069482/ovarian-response-and-in-vitro-fertilization-outcomes-after-salpingectomy-does-salpingectomy-indication-matter
#17
Nigel Pereira, Katherine P Pryor, Anna Voskuilen-Gonzalez, Jovana P Lekovich, Rony T Elias, Steven D Spandorfer, Zev Rosenwaks
STUDY OBJECTIVE: To investigate whether the ovarian response and pregnancy outcomes of patients undergoing in vitro fertilization (IVF) after salpingectomy is affected by the underlying indication for salpingectomy. DESIGN: Retrospective cohort study. DESIGN: Classification: II-3. SETTING: University-affiliated fertility center. PATIENTS: All patients <37 years of age undergoing IVF within 12 months of laparoscopic salpingectomy...
January 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28066833/the-role-of-g-csf-in-recurrent-implantation-failure-a-randomized-double-blind-placebo-control-trial
#18
Fatemeh Davari-Tanha, Ensieh Shahrokh Tehraninejad, Mohadese Ghazi, Zahra Shahraki
BACKGROUND: Recurrent implantation failure (RIF) is the absence of implantation after three consecutive In Vitro Fertilization (IVF) cycles with transferring at least four good quality embryos in a minimum of three fresh or frozen cycles in a woman under 40 years. The definition and management of RIF is under constant scrutiny. OBJECTIVE: To investigate the effects of Granulocyte colony stimulating factor (G-CSF) on RIF, pregnancy rate, abortion rate and implantation rates...
December 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28063801/effect-of-mid-follicular-phase-recombinant-lh-versus-urinary-hcg-supplementation-in-poor-ovarian-responders-undergoing-ivf-a-prospective-double-blinded-randomized-study
#19
Sze Man Jennifer Mak, Wai Yee Wong, Hoi Sze Chung, Pui Wah Chung, Grace Wing Shan Kong, Tin Chiu Li, Lai Ping Cheung
Luteinizing hormone (LH) is crucial for the development of follicular growth and oocyte maturation, especially in the management of poor ovarian responders (PORs). This study presents the results of a prospective double-blinded randomized study to compare the effect of mid-follicular phase recombinant LH (rLH) supplementation with urinary human chorionic gonadotrophin (uHCG) supplementation when using a fixed gonadotrophin-releasing hormone (GnRH) antagonist protocol in IVF cycles. A total of 49 women with poor ovarian response (POR) according to the Bologna criteria were recruited...
December 16, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28062551/new-stimulation-regimens-endogenous-and-exogenous-progesterone-use-to-block-the-lh-surge-during-ovarian-stimulation-for-ivf
#20
REVIEW
Nathalie Massin
BACKGROUND: The advent of embryo and oocyte vitrification today gives reproductive specialists an opportunity to consider new strategies for improving the practice and results of IVF attempts. As the freezing of entire cohorts does not compromise, and may even improve, the results of IVF attempts, it is possible to break away from the standard sequence of stimulation-retrieval-transfer. The constraints associated with ovarian stimulation in relation to the potential harmful effects of the hormonal environment on endometrial receptivity can be avoided...
January 5, 2017: Human Reproduction Update
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