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https://www.readbyqxmd.com/read/28887704/-indication-and-limitations-of-meniscus-replacement
#1
REVIEW
C Stärke, S Kopf, R Becker
BACKGROUND: Meniscal lesions are among the most important musculoskeletal disorders and are the most common indication for knee joint arthroplasty. However, the structural integrity and function is rarely retained, and a loss of tissue results. Thus, there is a huge demand for meniscal replacement options. CURRENT PROCEDURES: Autografts were used in the past but did not fulfill expectations. Meniscus allografts have been developed to be a viable treatment option...
September 8, 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28859517/a-novel-approach-for-meniscal-regeneration-using-kartogenin-treated-autologous-tendon-graft
#2
He Huang, Hongyao Xu, Jianning Zhao
BACKGROUND: The meniscus is one of the most commonly injured parts of the body, and meniscal healing is difficult. HYPOTHESIS: Kartogenin (KGN) induces tendon stem cells (TSCs) to differentiate into cartilage cells in vitro and form meniscus-like tissue in vivo. A damaged meniscus can be replaced with a KGN-treated autologous tendon graft. STUDY DESIGN: Controlled laboratory study. METHODS: In the in vitro experiments, TSCs were isolated from rabbit patellar tendons and cultured with various concentrations of KGN, from 0 to 1000 µM...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28805136/the-ovine-model-for-meniscus-tissue-engineering-considerations-of-anatomy-function-implantation-and-evaluation
#3
Andrzej Brzezinski, Salim A Ghodbane, Jay M Patel, Barbara A Perry, Charles J Gatt, Michael G Dunn
Meniscus injuries represent one of the most-common intra-articular knee injuries. The current treatment options include meniscectomy and allograft transplantation, both with poor long-term outcomes. Therefore, there is a need for regenerative techniques to restore meniscal function. In order to pre-clinically test scaffolds for meniscus replacement, large-animal models need to be established and standardized. This review establishes the anatomical and compositional similarities between the human and sheep menisci and provides guidance for implantation and evaluation of such devices...
August 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28772388/an-overview-of-scaffold-design-and-fabrication-technology-for-engineered-knee-meniscus
#4
REVIEW
Jie Sun, Sanjairaj Vijayavenkataraman, Hang Liu
Current surgical treatments for meniscal tears suffer from subsequent degeneration of knee joints, limited donor organs and inconsistent post-treatment results. Three clinical scaffolds (Menaflex CMI, Actifit(®) scaffold and NUsurface(®) Meniscus Implant) are available on the market, but additional data are needed to properly evaluate their safety and effectiveness. Thus, many scaffold-based research activities have been done to develop new materials, structures and fabrication technologies to mimic native meniscus for cell attachment and subsequent tissue development, and restore functionalities of injured meniscus for long-term effects...
January 3, 2017: Materials
https://www.readbyqxmd.com/read/28757192/delivery-of-epidermalgrowthfactor-receptor-inhibitor-via-a-customized-collagen-scaffold-promotes-meniscal-defect-regeneration-in-a-rabbit-model
#5
Zongyou Pan, Yan Wu, Xiaolei Zhang, Qianbao Fu, Jun Li, Yang Yang, Dongsheng Yu, Yuzi Xu, Xiaolang Lu, Heng Sun, Xianzhu Zhang, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang
Meniscal injury is one of the most common knee joint injuries, which remains an intractable challenge in clinical practice to date. Aberrant epidermalgrowthfactor receptor (EGFR) activation levels in both human and mice menisci following injury, prompted us to investigate the functional role of EGFR by utilizing an inducible cartilage-specific EGFR-deficient mouse model. We demonstrated that conditional EGFR deletion in mice resulted in increased partial meniscectomy-induced ECM production within the meniscus, which is comparable to utilization of the small molecule EGFR inhibitor, gefitinib, to block EGFR activity...
July 27, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28752186/low-impact-sports-activities-are-feasible-after-meniscus-transplantation-a-systematic-review
#6
REVIEW
Sue D Barber-Westin, Frank R Noyes
PURPOSE: To determine sports activities achieved after meniscus transplantation and if associations exist between sports activity levels and transplant failure or progression of tibiofemoral osteoarthritis (OA). METHODS: A systematic search was performed using PubMed and Cochrane online databases. Inclusionary criteria were English language, clinical trials published from 1996 through May 2017, minimum 2 years of follow-up, and sports activity data reported. RESULTS: Twenty-eight studies were included in which 1521 menisci were implanted into 1497 patients...
July 27, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28748491/polyurethane-meniscal-scaffolds-lead-to-better-clinical-outcomes-but-worse-articular-cartilage-status-and-greater-absolute-meniscal-extrusion
#7
Young-Soo Shin, Hoon-Nyun Lee, Hyun-Bo Sim, Hyun-Jung Kim, Dae-Hee Lee
PURPOSE: Implantation of polyurethane (PU) meniscal scaffolds has become a popular procedure to provide a scaffold for vessel ingrowth and meniscal tissue regeneration in patients with partial meniscal defects. However, it is unclear whether PU meniscal scaffolds lead to better clinical and magnetic resonance imaging (MRI) outcomes post-operatively. This meta-analysis compared the clinical and MRI outcomes in patients with partial meniscal defects treated with PU meniscal scaffolds. METHODS: This meta-analysis reviewed all studies that assessed Lysholm score, International Knee Documentation Committee (IKDC) score, visual analogue scale (VAS) for pain, Tegner score, Knee Injury and Osteoarthritis Outcomes Score (KOOS), articular cartilage (AC), absolute meniscal extrusion (AME), morphology and size (MS), signal intensity (SI) of meniscal implant, and interface of the implant-residual meniscus complex (IIRMC) in patients with partial meniscal defects treated with PU meniscal scaffolds...
July 26, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28729605/evaluating-the-effects-of-material-properties-of-artificial-meniscal-implant-in-the-human-knee-joint-using-finite-element-analysis
#8
Duraisamy Shriram, Gideon Praveen Kumar, Fangsen Cui, Yee Han Dave Lee, Karupppasamy Subburaj
Artificial meniscal implants may replace severely injured meniscus and restore the normal functionality of the knee joint. Implant material stiffness and shape influence the longevity of implantations. This study, using 3D finite element analysis, aimed to evaluate the effects of material stiffness variations of anatomically shaped artificial meniscal implant in the knee joint. Finite element simulations were conducted on five different cases including intact knee, medial meniscectomized knee, and the knee joint with the meniscal implant with three distinct material stiffness...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28719787/in-vivo-performance-of-a-novel-anatomically-shaped-total-meniscal-prosthesis-made-of-polycarbonate-urethane-a-12-month-evaluation-in-goats
#9
Anne C T Vrancken, Gerjon Hannink, Wojciech Madej, Nico Verdonschot, Tony G van Tienen, Pieter Buma
BACKGROUND: Injury or loss of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. However, the treatment options for symptomatic patients with total meniscectomy are limited. Therefore, we developed a novel, anatomically shaped, total meniscal implant made of polycarbonate urethane. PURPOSE: To evaluate the in vivo performance of this novel total meniscal implant. The assessment particularly focused on the implant's response to long-term physiological loading in a goat model and its chondroprotective capacity in comparison to clinically relevant controls...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28706814/tibial-allograft-transfer-for-medial-tibial-plateau-resurfacing
#10
Jonathan A Godin, Salvatore Frangiamore, Jorge Chahla, Mark E Cinque, Nicholas N DePhillipo, Robert F LaPrade
A large cartilage lesion of the tibial plateau with a deficient meniscus in a young patient is a challenging pathology for the orthopaedic surgeon due to the limited options available. While hemiarthroplasty procedures can be an option, the risk of revision in a young patient is high, and therefore a reconstructive procedure is advocated. The purpose of this Technical Note is to describe our technique for tibial plateau resurfacing, including the preparation and implantation of a medial tibial plateau and medial meniscal allograft, in a patient with a post-traumatic KD-4 knee dislocation with a medial tibial plateau rim fracture, medial meniscus deficiency, and medial tibiofemoral joint subluxation...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28622089/large-animal-models-of-meniscus-repair-and-regeneration-a-systematic-review-of-the-state-of-the-field
#11
Sonia Bansal, Niobra M Keah, Alexander L Neuwirth, Olivia O'Reilly, Feini Qu, Breanna N Seiber, Sai Mandalapu, Robert L Mauck, Miltiadis H Zgonis
Injury to the meniscus is common, but few viable strategies exist for its repair or regeneration. To address this, animal models have been developed to translate new treatment strategies toward the clinic. However, there is not yet a regulatory document guiding such studies. The purpose of this study was to carry out a systematic review of the literature on meniscus treatment methods and outcomes to define the state of the field. Public databases were queried by using search terms related to animal models and meniscus injury and/or repair over the years 1980-2015...
August 4, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28610487/establishment-of-novel-meniscal-scaffold-structures-using-polyglycolic-and-poly-l-lactic-acids
#12
Tomohiko Murakami, Shuhei Otsuki, Kosuke Nakagawa, Yoshinori Okamoto, Tae Inoue, Yuki Sakamoto, Hideki Sato, Masashi Neo
The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus scaffold with polyglycolic acid or poly-l-lactic acid. Four types of scaffolds were implanted into Japanese white rabbits: poly-l-lactic acid sponge poly-l-lactic acid, PGA-coated PLLA sponge, PGA lamination, and film-coated PGA lamination. Samples were harvested at 8 and 12 weeks after implantation, and a compression stress test was performed. The meniscus size and Ishida scores were evaluated for regenerated tissue...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28469288/friction-properties-of-a-new-silk-fibroin-scaffold-for-meniscal-replacement
#13
Daniela Warnecke, N B Schild, S Klose, H Joos, R E Brenner, O Kessler, N Skaer, R Walker, M Freutel, A Ignatius, L Dürselen
The menisci protect the articular cartilage by reducing contact pressure in the knee. To restore their function after injury, a new silk fibroin replacement scaffold was developed. To elucidate its tribological properties, friction of the implant was tested against cartilage and glass, where the latter is typically used in tribological cartilage studies. The silk scaffold exhibited a friction coefficient against cartilage of 0.056, which is higher than meniscus against cartilage but in range of the requirements for meniscal replacements...
May 2017: Tribology International
https://www.readbyqxmd.com/read/28455166/biomechanical-performance-of-a-collagen-meniscus-implant-with-regard-to-suture-material-and-irrigation-fluid
#14
Clemens Gwinner, Philipp von Roth, Sebastian Schmidt, Jan-Erik Ode, Dag Wulsten, Arnd Hoburg
BACKGROUND: The role of meniscus scaffolds remains controversial as failure rates remain high. The aim of this study was to evaluate the pullout strength of different suture materials used for fixation of the Collagen Meniscus Implant (CMI) regarding different suture materials, and type or temperature of irrigation fluid. METHODS: One-hundred and twelve specimens were utilized with horizontal sutures and mounted to a dedicated test device. Loads were applied perpendicular to the CMI, until failure...
April 25, 2017: Knee
https://www.readbyqxmd.com/read/28437755/an-in-vitro-study-of-cartilage-meniscus-tribology-to-understand-the-changes-caused-by-a-meniscus-implant
#15
Sara Ehsani Majd, Aditya Iman Rizqy, Hans J Kaper, Tannin A Schmidt, Roel Kuijer, Prashant K Sharma
Active lifestyles increase the risk of meniscal injury. A permanent meniscus implant of polycarbonate urethane (PCU) is a promising treatment to postpone/prevent total knee arthroplasty. Study of the changes in articular cartilage tribology in the presence of PCU is essential in developing the optimum meniscus implant. Therefore, a cartilage-meniscus reciprocating, sliding model was developed in vitro, mimicking the stance and swing phases of the gait cycle. The meniscus was further replaced with PCU and surface-modified PCUs (with C18 chains, mono-functional polydimethylsiloxane groups and mono-functional polytetrafluoroethylene groups) to study the changes...
April 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28433348/the-influence-of-polyethylene-bearing-thickness-on-the-tibiofemoral-kinematics-of-a-bicruciate-retaining-total-knee-arthroplasty
#16
Geert Peersman, Josh Slane, Margo Dirckx, Arne Vandevyver, Philipp Dworschak, Thomas J Heyse, Lennart Scheys
BACKGROUND: The recently reintroduced bicruciate retaining Total Knee Arthroplasty (BCR TKA) is an effort to reproduce kinematics closer to the native knee. However, there is no data on appropriate balancing with this implant. Balancing is crucial and challenging as medial and lateral polyethylene (PE) inlays are modular, which allows for placement of different thicknesses in the medial and lateral compartments. This study aimed at providing a detailed kinematic view on balancing BCR TKA...
April 19, 2017: Knee
https://www.readbyqxmd.com/read/28407495/stem-cell-delivery-in-tissue-specific-hydrogel-enabled-meniscal-repair-in-an-orthotopic-rat-model
#17
Xiaoning Yuan, Yiyong Wei, Aránzazu Villasante, Johnathan J D Ng, Derya E Arkonac, Pen-Hsiu Grace Chao, Gordana Vunjak-Novakovic
Interest in non-invasive injectable therapies has rapidly risen due to their excellent safety profile and ease of use in clinical settings. Injectable hydrogels can be derived from the extracellular matrix (ECM) of specific tissues to provide a biomimetic environment for cell delivery and enable seamless regeneration of tissue defects. We investigated the in situ delivery of human mesenchymal stem cells (hMSCs) in decellularized meniscus ECM hydrogel to a meniscal defect in a nude rat model. First, decellularized meniscus ECM hydrogel retained tissue-specific proteoglycans and collagens, and significantly upregulated expression of fibrochondrogenic markers by hMSCs versus collagen hydrogel alone in vitro...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28370168/major-complications-of-tibial-tuberosity-advancement-in-1613-dogs
#18
Mario Costa, Diane Craig, Tony Cambridge, Peter Sebestyen, Yuhua Su, Maria A Fahie
OBJECTIVES: To report major postoperative complications in 1613 dogs with tibial tuberosity advancement (TTA). STUDY DESIGN: Retrospective case series. SAMPLE POPULATION: Dogs (n = 1613) with cranial cruciate ligament deficiency treated with TTA. METHODS: Medical records of TTAs performed between December 2007-2013 were reviewed for age, sex, weight, contralateral stifle surgery, surgical approach, duration of preoperative lameness, presence of meniscal damage, concurrent patellar luxation and simultaneous bilateral TTA...
May 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28364144/current-advances-in-the-development-of-natural-meniscus-scaffolds-innovative-approaches-to-decellularization-and-recellularization
#19
REVIEW
Yunbin Chen, Jiaxin Chen, Zeng Zhang, Kangliang Lou, Qi Zhang, Shengyu Wang, Jinhu Ni, Wenyue Liu, Shunwu Fan, Xianfeng Lin
The increasing rate of injuries to the meniscus indicates the urgent need to develop effective repair strategies. Irreparably damaged menisci can be replaced and meniscus allografts represent the treatment of choice; however, they have several limitations, including availability and compatibility. Another approach is the use of artificial implants but their chondroprotective activities are still not proved clinically. In this situation, tissue engineering offers alternative natural decellularized extracellular matrix (ECM) scaffolds, which have shown biomechanical properties comparable to those of native menisci and are characterized by low immunogenicity and promising regenerative potential...
March 31, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28351490/high-meniscal-slope-angle-as-a-risk-factor-for-meniscal-allograft-extrusion
#20
P Łuczkiewicz, K Daszkiewicz, J Chróścielewski, W Witkowski, L Kuik
A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allograft transplantation. Because a meniscal extrusion is associated with a cartilage deterioration and the progression of osteoarthritis there is a great interest in how to prevent this phenomenon...
April 2017: Medical Hypotheses
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