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https://www.readbyqxmd.com/read/27895039/region-specific-effect-of-the-decellularized-meniscus-extracellular-matrix-on-mesenchymal-stem-cell-based-meniscus-tissue-engineering
#1
Kazunori Shimomura, Benjamin B Rothrauff, Rocky S Tuan
BACKGROUND: The meniscus is the most commonly injured knee structure, and surgical repair is often ineffective. Tissue engineering-based repair or regeneration may provide a needed solution. Decellularized, tissue-derived extracellular matrices (ECMs) have received attention for their potential use as tissue-engineered scaffolds. In considering meniscus-derived ECMs (mECMs) for meniscus tissue engineering, it is noteworthy that the inner and outer regions of the meniscus have different structural and biochemical features, potentially directing the differentiation of cells toward region-specific phenotypes...
November 28, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27892399/a-suture-technique-for-easier-reduction-and-repair-of-bucket-handle-meniscal-tears-while-using-the-all-inside-devices
#2
Engin Çetinkaya, Ersin Kuyucu, Murat Gül, Osman Lapçin, Kutalmış Albayrak, Sarper Gürsu
Arthroscopic repair of bucket-handle meniscal tears is difficult due to their complex pathology. Many meniscal repair techniques such as all-inside, inside-out, and outside-in have been described for the treatment of these tears. Loss of reduction is a likely complication with the use of new-generation, all-inside suture instruments, as the tip of the needle is extracted following advancement of the first implant behind the capsule. The complication may be encountered quite often and renders the use of the meniscus repair instrument unusable and causes an irreparable iatrogenic injury in the meniscus...
2016: SICOT-J
https://www.readbyqxmd.com/read/27836691/the-genovese-grading-scale-is-not-reliable-for-mr-assessment-of-collagen-meniscus-implants
#3
A Hirschmann, F F Schiapparelli, L Schenk, L Keller, F Amsler, M T Hirschmann
BACKGROUND: The purpose of the study was to evaluate the intra- and inter-observer reliabilities of the Genovese grading on MRI in patients after collagen meniscus substitution. METHODS: 84 MRI images of 74 consecutive patients who underwent partial meniscus substitution using collagen meniscus implant (CMI) were assessed. MRIs were evaluated using the Genovese grading system. Furthermore, meniscal extrusion was assessed. Two observers performed the grading twice, blinded to each other and to the previous results, with a six weeks interval...
November 8, 2016: Knee
https://www.readbyqxmd.com/read/27826794/the-challenge-in-using-mesenchymal-stromal-cells-for-recellularization-of-decellularized-cartilage
#4
REVIEW
Zhao Huang, Owen Godkin, Gundula Schulze-Tanzil
Some decellularized musculoskeletal extracellular matrices (ECM)s derived from tissues such as bone, tendon and fibrocartilaginous meniscus have already been clinical use for tissue reconstruction. Repair of articular cartilage with its unique zonal ECM architecture and composition is still an unsolved problem, and the question is whether allogenic or xenogeneic decellularized cartilage ECM could serve as a biomimetic scaffold for this purpose.Hence, this survey outlines the present state of preparing decellularized cartilage ECM-derived scaffolds or composites for reconstruction of different cartilage types and of reseeding it particularly with mesenchymal stromal cells (MSCs)...
November 8, 2016: Stem Cell Reviews
https://www.readbyqxmd.com/read/27748548/preparation-of-designed-poly-trimethylene-carbonate-meniscus-implants-by-stereolithography-challenges-in-stereolithography
#5
Bas van Bochove, Gerjon Hannink, Pieter Buma, Dirk W Grijpma
Three-armed poly(trimethylene carbonate) macromers with a relatively high molecular weight of 28.9 kg mol(-1) are prepared by ring opening polymerization and subsequent functionalization with methacrylate end groups. A resin suitable for processing by stereolithography is developed using propylene carbonate as a diluent, a photoinitiator, and a dye to control the curing characteristics. The difficulties in building designed structures with digital light processing stereolithography and the ways of optimizing the resin compositions are described in detail...
October 17, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27726454/rapidly-dissociated-autologous-meniscus-tissue-enhances-meniscus-healing-an-in-vitro-study
#6
Piya-On Numpaisal, Benjamin B Rothrauff, Riccardo Gottardi, Chung-Liang Chien, Rocky S Tuan
PURPOSE: Treatment of meniscus tears is a persistent challenge in orthopedics. Although cell therapies have shown promise in promoting fibrocartilage formation in in vitro and preclinical studies, clinical application has been limited by the paucity of autologous tissue and the need for ex vivo cell expansion. Rapid dissociation of the free edges of the anterior and posterior meniscus with subsequent implantation in a meniscus lesion may overcome these limitations. The purpose of this study was to explore the effect of rapidly dissociated meniscus tissue in enhancing neotissue formation in a radial meniscus tear, as simulated in an in vitro explant model...
October 11, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27718449/amecm-dcb-scaffold-prompts-successful-total-meniscus-reconstruction-in-a-rabbit-total-meniscectomy-model
#7
Zhiguo Yuan, Shuyun Liu, Chunxiang Hao, Weimin Guo, Shuang Gao, Mingjie Wang, Mingxue Chen, Zhen Sun, Yichi Xu, Yu Wang, Jiang Peng, Mei Yuan, Quan-Yi Guo
Tissue-engineered meniscus regeneration is a very promising treatment strategy for meniscus lesions. However, generating the scaffold presents a huge challenge for meniscus engineering as this has to meet particular biomechanical and biocompatibility requirements. In this study, we utilized acellular meniscus extracellular matrix (AMECM) and demineralized cancellous bone (DCB) to construct three different types of three-dimensional porous meniscus scaffold: AMECM, DCB, and AMECM/DCB, respectively. We tested the scaffolds' physicochemical characteristics and observed their interactions with meniscus fibrochondrocytes to evaluate their cytocompatibility...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27677916/biological-therapies-in-regenerative-sports-medicine
#8
Isabel Andia, Nicola Maffulli
Regenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action...
September 28, 2016: Sports Medicine
https://www.readbyqxmd.com/read/27670757/scaffold-free-tissue-engineered-allogenic-adipose-derived-stem-cells-promote-meniscus-healing
#9
Tatsuhiro Toratani, Junsuke Nakase, Hitoaki Numata, Takeshi Oshima, Yasushi Takata, Koichi Nakayama, Hiroyuki Tsuchiya
PURPOSE: To determine whether meniscal tissue could be healed histologically by the implantation of allogenic three-dimensional formed adipose-derived stem cells (ADSCs) in a rabbit model of partial meniscectomy. METHODS: Forty Japanese white rabbits (aged 15-17 weeks) were assigned to 2 groups. Defects 1.5 mm in diameter were created in the anterior horn of the medial menisci. The defects were left empty in the control group and were filled with cylindrical plugs of allogenic ADSCs extracted from adipose tissue in the experimental group...
September 23, 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27612948/secreted-trophic-factors-of-mesenchymal-stem-cells-support-neurovascular-and-musculoskeletal-therapies
#10
REVIEW
Heidi R Hofer, Rocky S Tuan
Adult mesenchymal stem cells (MSCs) represent a subject of intense experimental and biomedical interest. Recently, trophic activities of MSCs have become the topic of a number of revealing studies that span both basic and clinical fields. In this review, we focus on recent investigations that have elucidated trophic mechanisms and shed light on MSC clinical efficacy relevant to musculoskeletal applications. Innate differences due to MSC sourcing may play a role in the clinical utility of isolated MSCs. Pain management, osteochondral, nerve, or blood vessel support by MSCs derived from both autologous and allogeneic sources have been examined...
September 9, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27550636/negative-outcomes-of-poly-l-lactic-acid-fiber-reinforced-scaffolds-in-an-ovine-total-meniscus-replacement-model
#11
Jay M Patel, Aaron R Merriam, Joachim Kohn, Charles J Gatt, Michael G Dunn
Our objective was to test the efficacy of collagen-hyaluronan scaffolds reinforced with poly(l-lactic acid) (PLLA) fibers in an ovine total meniscus replacement model. Scaffolds were implanted into 9 sheep (n = 1 at 8 weeks, n = 2 at 16 weeks, n = 3 at both 24, 32 weeks) following total medial meniscectomy. From 16 weeks on, explants were characterized by confined compression creep, histological, and biochemical analyses. Articular surfaces were observed macroscopically and damage was ranked histologically using the Mankin score...
September 2016: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/27484043/analysis-of-3d-strain-in-the-human-medial-meniscus
#12
S Kolaczek, C Hewison, S Caterine, M X Ragbar, A Getgood, K D Gordon
This study presents a method to evaluate three-dimensional strain in meniscal tissue using medical imaging. Strain is calculated by tracking small teflon markers implanted within the meniscal tissue using computed tomography imaging. The results are presented for strains in the middle and posterior third of the medial menisci of 10 human cadaveric knees, under simulated physiologically relevant loading. In the middle position, an average compressive strain of 3.4% was found in the medial-lateral direction, and average tensile strains of 1...
October 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27432054/treatment-of-painful-irreparable-partial-meniscal-defects-with-a-polyurethane-scaffold-midterm-clinical-outcomes-and-survival-analysis
#13
Aad Dhollander, Peter Verdonk, René Verdonk
BACKGROUND: A biodegradable polyurethane scaffold was designed to fulfill a challenging clinical need in the treatment of patients with painful, irreparable partial meniscal defects. HYPOTHESIS: The use of an acellular polyurethane scaffold for new tissue generation in irreparable, partial meniscal defects provides both midterm pain relief and improved functionality. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A total of 44 patients with irreparable, partial meniscal defects (29 medial and 15 lateral) were implanted with a polyurethane scaffold in a prospective, single-arm proof-of-principle study with a minimum 5-year follow-up...
July 18, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27410773/a-clinical-platform-for-understanding-the-relationship-between-joint-contact-mechanics-articular-cartilage-changes-after-meniscal-surgery
#14
Suzanne Maher, Hongsheng Wang, Matthew F Koff, Nicole Belkin, Hollis G Potter, Scott Rodeo
Injury to the meniscus of the knee has been implicated as a significant risk factor for the subsequent development of osteoarthritis, but the mechanisms of joint degeneration are unclear. Our objective was to develop a clinically applicable methodology to evaluate the relationship of joint contact mechanics at the time of surgery to biological changes of articular cartilage as a function of time following surgery. A series of pre-, intra- and post-operative protocols were developed which utilized electronic sensors for the direct measurement of contact mechanics, and advanced imaging to assess cartilage health...
July 13, 2016: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27409467/structural-changes-induced-by-a-corneal-shape-changing-inlay-deduced-from-optical-coherence-tomography-and-wavefront-measurements
#15
Alan J Lang, Keith Holliday, Arturo Chayet, Enrique Barragán-Garza, Nikhita Kathuria
PURPOSE: Changes to the anterior stroma and epithelium induced by a meniscus-shaped corneal inlay are presented. The hypothesis that local curvature is a driver of epithelial remodeling is tested. METHODS: Records of 30 subjects enrolled in a prospective clinical investigation of the inlay, implanted in emmetropic presbyopic subjects, were analyzed. The change to the anterior corneal surface was measured using wavefront techniques. The epithelial thinning profile was measured using Fourier domain optical coherence tomography...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27395355/polyurethane-based-cell-free-scaffold-for-the-treatment-of-painful-partial-meniscus-loss
#16
G Filardo, E Kon, F Perdisa, A Sessa, A Di Martino, M Busacca, S Zaffagnini, M Marcacci
PURPOSE: The aim of this study was to document, at mid-term follow-up, the clinical and MRI outcome of a polyurethane-based cell-free scaffold implanted to treat painful partial meniscus loss. METHODS: Eighteen consecutive patients were enrolled and treated with arthroscopic polyurethane meniscal scaffold implantation and, in case of other comorbidities, with concurrent surgical procedures: 16 patients (9 men and 7 women, mean age 45 ± 13 years, mean BMI 25 ± 3, 12 medial and 4 lateral implants) were prospectively evaluated with the subjective and objective IKDC and the Tegner scores at 24, 36, 48, 60, and 72 months of follow-up...
July 9, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27392321/degradation-behavior-of-and-tissue-response-to-photo-crosslinked-poly-trimethylene-carbonate-networks
#17
Jan J Rongen, Bas van Bochove, Gerjon Hannink, Dirk W Grijpma, Pieter Buma
Photo-crosslinked networks prepared from three-armed methacrylate functionalized PTMC oligomers (PTMC-tMA macromers) are attractive materials for developing an anatomically correct meniscus scaffold. In this study, we evaluated cell specific biocompatibility, in vitro and in vivo degradation behavior of, and tissue response to, such PTMC networks. By evaluating PTMC networks prepared from PTMC-tMA macromers of different molecular weights, we were able to assess the effect of macromer molecular weight on the degradation rate of the PTMC network obtained after photo-crosslinking...
November 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27347833/assessment-of-regeneration-in-meniscal-lesions-by-use-of-mesenchymal-stem-cells-derived-from-equine-bone-marrow-and-adipose-tissue
#18
Maria L González-Fernández, Saúl Pérez-Castrillo, Jaime A Sánchez-Lázaro, Julio G Prieto-Fernández, Maria E López-González, Sandra Lobato-Pérez, Bruno J Colaço, Elías R Olivera, Vega Villar-Suárez
OBJECTIVE To assess the ability to regenerate an equine meniscus by use of a collagen repair patch (scaffold) seeded with mesenchymal stem cells (MSCs) derived from bone marrow (BM) or adipose tissue (AT). SAMPLE 6 female Hispano-Breton horses between 4 and 7 years of age; MSCs from BM and AT were obtained for the in vitro experiment, and the horses were subsequently used for the in vivo experiment. PROCEDURES Similarities and differences between MSCs derived from BM or AT were investigated in vitro by use of cell culture...
July 2016: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/27331034/meniscus-tear-surgery-and-meniscus-replacement
#19
REVIEW
Javier Vaquero, Francisco Forriol
OBJECTIVE: the menisci are easily injured and difficult to repair. The aim of this study was to analyze the current state of meniscal surgery aimed at preserving morphology and conserving the biomechanics of the knee to prevent joint degeneration. METHODOLOGY: a search of the electronic medical literature database Medline was conducted, from http://www.ncbi.nlm.nih.gov/pubmed. The search was not limited by language. Candidate articles were identified by searching for those that included the keywords meniscus, surgery, suture, implant, allograft...
January 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/27159292/local-administration-of-simvastatin-stimulates-healing-of-an-avascular-meniscus-in-a-rabbit-model-of-a-meniscal-defect
#20
Shurong Zhang, Takehiko Matsushita, Ryosuke Kuroda, Kyohei Nishida, Tokio Matsuzaki, Tomoyuki Matsumoto, Koji Takayama, Kanto Nagai, Shinya Oka, Yasuhiko Tabata, Kouki Nagamune, Masahiro Kurosaka
BACKGROUND: Repair of an avascular meniscus is challenging because of its low capacity for healing. Several reports have shown that simvastatin stimulates the anabolic activity of intervertebral fibrochondrocytes, suggesting that simvastatin may be used for the treatment of meniscal defects. PURPOSE: To test whether the local administration of simvastatin stimulates healing of an avascular meniscus in rabbits. STUDY DESIGN: Controlled laboratory study...
July 2016: American Journal of Sports Medicine
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