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Meniscus scaffold

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https://www.readbyqxmd.com/read/29187260/histological-changes-of-the-meniscus-following-an-osteochondral-lesion
#1
G M Peretti, I Tessaro, L Montanari, U Polito, A Di Giancamillo, M Di Giancamillo, A Marmotti, A Montaruli, E Roveda, L Mangiavini
In the last few years, different tissue engineering strategies have been developed for the repair of osteochondral lesions. When the osteochondral scaffold is implanted on the femoral condyle, the meniscus might be affected by the implant and might undergo a progressive degeneration. The aim of our study is to analyze the morphological changes of the meniscus following an osteochondral lesion and the implant of a biphasic scaffold. A critical osteochondral defect was generated in the medial femoral condyle of mature sheep...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29182439/chondrocyte-based-intraoperative-processing-strategies-for-the-biological-augmentation-of-a-polyurethane-meniscus-replacement
#2
Srujana Vedicherla, Sara Romanazzo, Daniel J Kelly, Conor T Buckley, Cathal J Moran
Purpose/aim of study: Menisectomies account for over 1.5 million surgical interventions in Europe annually, and there is a growing interest in regenerative strategies to improve outcomes in meniscal replacement. The overall objective of this study was to evaluate the role of intraoperatively applied fresh chondrocyte (FC) isolates compared to minced cartilage (MC) fragments, used without cell isolation, to improve bioactivity and tissue integration when combined with a polyurethane replacement. MATERIALS AND METHODS: First, to optimize the intraoperative cell isolation protocol, caprine articular cartilage biopsies were digested with 750 U/ml or 3000 U/ml collagenase type II (ratio of 10 ml per g of tissue) for 30 min, 1 h or 12 h with constant agitation and compared to culture-expanded chondrocytes in terms of matrix deposition when cultured on polyurethane scaffolds...
November 28, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29176654/programmed-biomolecule-delivery-to-enable-and-direct-cell-migration-for-connective-tissue-repair
#3
Feini Qu, Julianne L Holloway, John L Esterhai, Jason A Burdick, Robert L Mauck
Dense connective tissue injuries have limited repair, due to the paucity of cells at the wound site. We hypothesize that decreasing the density of the local extracellular matrix (ECM) in conjunction with releasing chemoattractive signals increases cellularity and tissue formation after injury. Using the knee meniscus as a model system, we query interstitial cell migration in the context of migratory barriers using a novel tissue Boyden chamber and show that a gradient of platelet-derived growth factor-AB (PDGF-AB) expedites migration through native tissue...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29128533/fabrication-of-dense-anisotropic-collagen-scaffolds-using-biaxial-compression
#4
Jared L Zitnay, Shawn P Reese, Garvin Tran, Niloofar Farhang, Robert D Bowles, Jeffrey A Weiss
We developed a new method to manufacture dense, aligned, and porous collagen scaffolds using biaxial plastic compression of type I collagen gels. Using a novel compression apparatus that constricts like an iris diaphragm, low density collagen gels were compressed to yield a permanently densified, highly aligned collagen material. Micro-porosity scaffolds was created using hydrophilic elastomer porogens that can be selectively removed following biaxial compression, with porosity modulated by using different porogen concentrations...
November 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29114640/evolution-of-osteochondritis-dissecans-of-the-lateral-femoral-condyle-combined-with-discoid-meniscus
#5
Erica Bulgheroni, Lorenzo Mattioli, Paolo Bulgheroni
The discoid meniscus is a rare anomaly of the knee that affects mostly the lateral meniscus and is often asymptomatic. The osteochondritis dissecans is a disorder of the subchondral bone and articular cartilage and occurs frequently associated with the discoid lateral meniscus. In the present case, we showed the evolution of this association related to surgical treatment. A patient with lateral knee pain and a magnetic resonance depicting a torn discoid lateral meniscus and osteochondritis dissecans of the lateral femoral condyle was treated with partial meniscectomy and meniscal sutures...
June 2017: Joints
https://www.readbyqxmd.com/read/29062478/mesenchymal-stem-cells-in-human-meniscal-regeneration-a-systematic-review
#6
REVIEW
Ernest Chew, Rohan Prakash, Wasim Khan
BACKGROUND: Stem cell regeneration is the holy grail of meniscal tissue repair. Currently, the best treatment is to preserve the original meniscus but if it fails, a partial meniscectomy is indicated to delay the onset of osteoarthritis. MATERIALS AND METHODS: The authors present a systematic review to determine the up-to-date evidence underlying the use of mesenchymal stem cells for meniscal regeneration in humans. A search was conducted using the electronic databases of MEDLINE/Pubmed, Google scholar, and the Cochrane Collaboration...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29060302/evaluation-of-histological-and-biomechanical-properties-on-engineered-meniscus-tissues-using-sonication-decellularization
#7
A Mardhiyah, M Sha'ban, A Azhim
Sonication decellularization treatment requires proper evaluations on its ability to decellularize meniscus tissue efficiently. This study was done to evaluate the histological and biomechanical properties within meniscus scaffolds. Van Gieson staining was done to evaluate the efficiency of cell removal in meniscus tissues. The consequences of treatment on viscoelastic properties are vital for scaffolds quality and were properly investigated. Picrosirius red and Safranin-O/Fast green staining was carried out to detect extracellular matrix materials (ECM)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29017608/autologous-mesenchymal-stem-cells-or-meniscal-cells-what-is-the-best-cell-source-for-regenerative-meniscus-treatment-in-an-early-osteoarthritis-situation
#8
Johannes Zellner, Girish Pattappa, Matthias Koch, Siegmund Lang, Johannes Weber, Christian G Pfeifer, Michael B Mueller, Richard Kujat, Michael Nerlich, Peter Angele
BACKGROUND: Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising results. However, studies have not found a consensus on the appropriate autologous cell source in a clinical situation, specifically in a challenging degenerative environment. The present study sought to evaluate the appropriate cell source for autologous meniscal repair in a demanding setting of early osteoarthritis...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28963018/temporal-development-of-near-native-functional-properties-and-correlations-with-qmri-in-self-assembling-fibrocartilage-treated-with-exogenous-lysyl-oxidase-homolog-2
#9
Pasha Hadidi, Derek D Cissell, Jerry C Hu, Kyriacos A Athanasiou
Advances in cartilage tissue engineering have led to constructs with mechanical integrity and biochemical composition increasingly resembling that of native tissues. In particular, collagen cross-linking with lysyl oxidase has been used to significantly enhance the mechanical properties of engineered neotissues. In this study, development of collagen cross-links over time, and correlations with tensile properties, were examined in self-assembling neotissues. Additionally, quantitative MRI metrics were examined in relation to construct mechanical properties as well as pyridinoline cross-link content and other engineered tissue components...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28887704/-indication-and-limitations-of-meniscus-replacement
#10
REVIEW
C Stärke, S Kopf, R Becker
BACKGROUND: Meniscal lesions are among the most important musculoskeletal disorders and are the most common indication for knee joint arthroplasty. However, the structural integrity and function is rarely retained, and a loss of tissue results. Thus, there is a huge demand for meniscal replacement options. CURRENT PROCEDURES: Autografts were used in the past but did not fulfill expectations. Meniscus allografts have been developed to be a viable treatment option...
October 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28805136/the-ovine-model-for-meniscus-tissue-engineering-considerations-of-anatomy-function-implantation-and-evaluation
#11
Andrzej Brzezinski, Salim A Ghodbane, Jay M Patel, Barbara A Perry, Charles J Gatt, Michael G Dunn
Meniscus injuries represent one of the most-common intra-articular knee injuries. The current treatment options include meniscectomy and allograft transplantation, both with poor long-term outcomes. Therefore, there is a need for regenerative techniques to restore meniscal function. To preclinically test scaffolds for meniscus replacement, large animal models need to be established and standardized. This review establishes the anatomical and compositional similarities between human and sheep menisci and provides guidance for implantation and evaluation of such devices...
September 29, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28783120/platelet-rich-fibrin-facilitates-rabbit-meniscal-repair-by-promoting-meniscocytes-proliferation-migration-and-extracellular-matrix-synthesis
#12
Chin-Chean Wong, Tzong-Fu Kuo, Tsung-Lin Yang, Yang-Hwei Tsuang, Ming-Fang Lin, Chung-Hsun Chang, Yun-Ho Lin, Wing P Chan
Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbit meniscocytes were cultured with different concentrations of PRF-conditioned medium, and were evaluated for their ability to stimulate cell migration, proliferation, and extracellular matrix formation...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28772388/an-overview-of-scaffold-design-and-fabrication-technology-for-engineered-knee-meniscus
#13
REVIEW
Jie Sun, Sanjairaj Vijayavenkataraman, Hang Liu
Current surgical treatments for meniscal tears suffer from subsequent degeneration of knee joints, limited donor organs and inconsistent post-treatment results. Three clinical scaffolds (Menaflex CMI, Actifit(®) scaffold and NUsurface(®) Meniscus Implant) are available on the market, but additional data are needed to properly evaluate their safety and effectiveness. Thus, many scaffold-based research activities have been done to develop new materials, structures and fabrication technologies to mimic native meniscus for cell attachment and subsequent tissue development, and restore functionalities of injured meniscus for long-term effects...
January 3, 2017: Materials
https://www.readbyqxmd.com/read/28765605/the-potential-of-using-semitendinosus-tendon-as-autograft-in-rabbit-meniscus-reconstruction
#14
Chenxi Li, Xiaoqing Hu, Qingyang Meng, Xin Zhang, Jingxian Zhu, Linghui Dai, Jin Cheng, Mingjin Zhong, Weili Shi, Bo Ren, Jiying Zhang, Xin Fu, Xiaoning Duan, Yingfang Ao
Since transplantation of meniscal allograft or artificial menisci is limited by graft sources and a series of adverse events, substitution for meniscus reconstruction still needs to be explored. Natural biomaterials, which can provide a unique 3-D microenvironment, remain a promising alternative for tissue engineering. Among them, autograft is a preferred option for its safety and excellent biocompatibility. In this study, we utilized semitendinosus tendon autograft in meniscus reconstruction to investigate its fibrochondrogenic metaplasticity potential and chondroprotective effect...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28757192/delivery-of-epidermal-growth-factor-receptor-inhibitor-via-a-customized-collagen-scaffold-promotes-meniscal-defect-regeneration-in-a-rabbit-model
#15
Zongyou Pan, Yan Wu, Xiaolei Zhang, Qianbao Fu, Jun Li, Yang Yang, Dongsheng Yu, Yuzi Xu, Xiaolang Lu, Heng Sun, Xianzhu Zhang, Boon Chin Heng, Varitsara Bunpetch, Shufang Zhang, Hongwei Ouyang
Meniscal injury is one of the most common knee joint injuries, which remains an intractable challenge in clinical practice to date. Aberrant epidermal growth factor receptor (EGFR) activation levels in both human and mice menisci following injury, prompted us to investigate the functional role of EGFR by utilizing an inducible cartilage-specific EGFR-deficient mouse model. We demonstrated that conditional EGFR deletion in mice resulted in increased partial meniscectomy-induced ECM production within the meniscus, which is comparable to utilization of the small molecule EGFR inhibitor, gefitinib, to block EGFR activity...
October 15, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28748491/polyurethane-meniscal-scaffolds-lead-to-better-clinical-outcomes-but-worse-articular-cartilage-status-and-greater-absolute-meniscal-extrusion
#16
Young-Soo Shin, Hoon-Nyun Lee, Hyun-Bo Sim, Hyun-Jung Kim, Dae-Hee Lee
PURPOSE: Implantation of polyurethane (PU) meniscal scaffolds has become a popular procedure to provide a scaffold for vessel ingrowth and meniscal tissue regeneration in patients with partial meniscal defects. However, it is unclear whether PU meniscal scaffolds lead to better clinical and magnetic resonance imaging (MRI) outcomes post-operatively. This meta-analysis compared the clinical and MRI outcomes in patients with partial meniscal defects treated with PU meniscal scaffolds. METHODS: This meta-analysis reviewed all studies that assessed Lysholm score, International Knee Documentation Committee (IKDC) score, visual analogue scale (VAS) for pain, Tegner score, Knee Injury and Osteoarthritis Outcomes Score (KOOS), articular cartilage (AC), absolute meniscal extrusion (AME), morphology and size (MS), signal intensity (SI) of meniscal implant, and interface of the implant-residual meniscus complex (IIRMC) in patients with partial meniscal defects treated with PU meniscal scaffolds...
July 26, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28703122/synergistic-effect-of-electrical-conductivity-and-biomolecules-on-human-meniscal-cell-attachment-growth-and-proliferation-in-poly-%C3%AE%C2%B5-caprolactone-nanocomposite-scaffolds
#17
Janarthanan Gopinathan, Mamatha M Pillai, K Santosh Sahanand, B K Dinakar Rai, Rajendran Selvakumar, Amitava Bhattacharyya
Poly-ε-caprolactone (PCL) based nanocomposite scaffolds with different concentrations of carbon nanofillers (carbon nanofibers (CNF), nanographite and exfoliated graphite) have been studied to investigate the effect of electrical conductivity and biomolecules supplementation for enhanced human meniscal cell attachment, growth and proliferation. Incorporation of carbon nanofillers was found to improve mechanical and electrical properties. CNF based nanocomposite scaffolds showed highest electrical conductivity with significant improvements in mechanical properties (more than 50% tensile strength increase than PCL with 10% (w/w) CNF)...
July 13, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28610487/establishment-of-novel-meniscal-scaffold-structures-using-polyglycolic-and-poly-l-lactic-acids
#18
Tomohiko Murakami, Shuhei Otsuki, Kosuke Nakagawa, Yoshinori Okamoto, Tae Inoue, Yuki Sakamoto, Hideki Sato, Masashi Neo
The purpose of this study was to evaluate various types of meniscus scaffolds that mimic the meniscus structure, and to establish a novel cell-free meniscus scaffold with polyglycolic acid or poly-l-lactic acid. Four types of scaffolds were implanted into Japanese white rabbits: poly-l-lactic acid sponge poly-l-lactic acid, PGA-coated PLLA sponge, PGA lamination, and film-coated PGA lamination. Samples were harvested at 8 and 12 weeks after implantation, and a compression stress test was performed. The meniscus size and Ishida scores were evaluated for regenerated tissue...
January 1, 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28598834/do-cell-based-tissue-engineering-products-for-meniscus-regeneration-influence-vascularization
#19
Matthias Koch, Tobias Ehrenreich, Gudrun Koehl, Girish Pattappa, Christian Pfeifer, Markus Loibl, Michael Müller, Michael Nerlich, Peter Angele, Johannes Zellner
BACKGROUND: Meniscus regeneration is observed within the peripheral, vascularized zone but decreases in the inner two thirds alongside the vascularization. Within this avascular area, cell-based tissue-engineering-approaches appears to be a promising strategy for the treatment of meniscal defects. OBJECTIVE: Evaluation of the angiogenic potential of cell-based tissue-engineering-products for meniscus healing. METHODS: Evaluation of angiogenesis induced by rabbit meniscus-pellets, meniscus-cells (MC) or mesenchymal stem-cells (MSC) in cell-based tissue-engineering-products within a rabbit meniscus-ring was performed using a transparent dorsal skin fold chamber in nude mice...
June 7, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28469288/friction-properties-of-a-new-silk-fibroin-scaffold-for-meniscal-replacement
#20
Daniela Warnecke, N B Schild, S Klose, H Joos, R E Brenner, O Kessler, N Skaer, R Walker, M Freutel, A Ignatius, L Dürselen
The menisci protect the articular cartilage by reducing contact pressure in the knee. To restore their function after injury, a new silk fibroin replacement scaffold was developed. To elucidate its tribological properties, friction of the implant was tested against cartilage and glass, where the latter is typically used in tribological cartilage studies. The silk scaffold exhibited a friction coefficient against cartilage of 0.056, which is higher than meniscus against cartilage but in range of the requirements for meniscal replacements...
May 2017: Tribology International
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