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Meniscus scaffold

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https://www.readbyqxmd.com/read/29928576/cyclic-compressive-loading-activates-angiotensin-ii-type-1-receptor-in-articular-chondrocytes-and-stimulates-hypertrophic-differentiation-through-a-g-protein-dependent-pathway
#1
Fumihisa Nakamura, Ichiro Tsukamoto, Shinji Inoue, Kazuhiko Hashimoto, Masao Akagi
Angiotensin II type 1 receptor (AT1R) appears to have a mechanosensing function in a number of cell types. The purpose of this study was to examine whether AT1R expressed in articular chondrocytes is involved in osteoarthritis (OA) progression in vivo and whether cyclic compressive loading activates the AT1R and stimulates hypertrophic differentiation of chondrocytes in vitro . The relationships between the modified Mankin score for cartilage degeneration and the expression of AT1R and type X collagen (Col X) were studied in mouse knees with OA induced using the destabilization-of-medial-meniscus model...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29908335/platelet-derived-growth-factor-coated-decellularized-meniscus-scaffold-for-integrative-healing-of-meniscus-tears
#2
Kwang Il Lee, Merissa Olmer, Jihye Baek, Darryl D D'Lima, Martin K Lotz
The aim of this study was to examine the potential of platelet-derived growth factor (PDGF)-coated decellularized meniscus scaffold in mediating integrative healing of meniscus tears by inducing endogenous cell migration. Fresh bovine meniscus was chemically decellularized and covalently conjugated with heparin and PDGF-BB. In vitro PDGF release kinetics was measured. The scaffold was transplanted into experimental tears in avascular bovine meniscus explants and cultured for 2 and 4 weeks. The number migrating and proliferating cells at the borderline between the scaffold and injured explant and PDGF receptor-β (PDGFR β) expressing cells were counted...
June 13, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29881226/the-use-of-platelet-rich-fibrin-with-platelet-rich-plasma-support-meniscal-repair-surgery
#3
Masahiko Kemmochi, Shigeru Sasaki, Masako Takahashi, Tomitaka Nishimura, Chisa Aizawa, Jun Kikuchi
Introduction: Platelet-rich fibrin (PRF) is the only autologous blood product that releases growth factors and has scaffolding properties. We hypothesized that the use of PRF and Platelet-rich plasma (PRP) would improve operative results, including the recovery of function and repaired meniscus. Materials and Methods: Seventeen patients underwent arthroscopic meniscus repair with PRF and PRP (PRF group) using our novel device for the injection of the PRF into the joint...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29847704/tissue-mimicry-in-morphology-and-composition-promotes-hierarchical-matrix-remodeling-of-invading-stem-cells-in-osteochondral-and-meniscus-scaffolds
#4
Kai Stuckensen, Andrea Schwab, Markus Knauer, Emma Muiños-López, Franziska Ehlicke, Jenny Reboredo, Froilán Granero-Moltó, Uwe Gbureck, Felipe Prósper, Heike Walles, Jürgen Groll
An integral approach toward in situ tissue engineering through scaffolds that mimic tissue with regard to both tissue architecture and biochemical composition is presented. Monolithic osteochondral and meniscus scaffolds are prepared with tissue analog layered biochemical composition and perpendicularly oriented continuous micropores by a newly developed cryostructuring technology. These scaffolds enable rapid cell ingrowth and induce zonal-specific matrix synthesis of human multipotent mesenchymal stromal cells solely through their design without the need for supplementation of soluble factors such as growth factors...
May 30, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29729765/editorial-commentary-polyurethane-meniscal-scaffold-a-perfect-fit-or-flop
#5
EDITORIAL
F Alan Barber
The goal of using a synthetic scaffold to establish a biomechanically functioning meniscus or provide an equivalent meniscus substitute is not achieved by the polycaprolactone-polyurethane Actifit scaffold. Recent research, that did not include a control group, shows that the revision rate is significant, and any improvements in patient outcomes could reflect the associated reconstructive surgery. Based on these data and similar published reports, it is premature to conclude that this implant is clinically indicated...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29663192/human-knee-meniscus-regeneration-strategies-a-review-on-recent-advances
#6
REVIEW
Mamatha M Pillai, J Gopinathan, R Selvakumar, Amitava Bhattacharyya
PURPOSE OF REVIEW: Lack of vascularity in the human knee meniscus often leads to surgical removal (total or partial meniscectomy) in the case of severe meniscal damage. However, complete recovery is in question after such removal as the meniscus plays an important role in knee stability. Thus, meniscus tissue regeneration strategies are of intense research interest in recent years. RECENT FINDINGS: The structural complexity and inhomogeneity of the meniscus have been addressed with processing technologies for precisely controlled three dimensional (3D) complex porous scaffold architectures, the use of biomolecules and nanomaterials...
June 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29581987/biochemical-stimulus-based-strategies-for-meniscus-tissue-engineering-and-regeneration
#7
REVIEW
Mingxue Chen, Weimin Guo, Shunag Gao, Chunxiang Hao, Shi Shen, Zengzeng Zhang, Zhenyong Wang, Zehao Wang, Xu Li, Xiaoguang Jing, Xueliang Zhang, Zhiguo Yuan, Mingjie Wang, Yu Zhang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Shuyun Liu, Quanyi Guo
Meniscus injuries are very common and still pose a challenge for the orthopedic surgeon. Meniscus injuries in the inner two-thirds of the meniscus remain incurable. Tissue-engineered meniscus strategies seem to offer a new approach for treating meniscus injuries with a combination of seed cells, scaffolds, and biochemical or biomechanical stimulation. Cell- or scaffold-based strategies play a pivotal role in meniscus regeneration. Similarly, biochemical and biomechanical stimulation are also important. Seed cells and scaffolds can be used to construct a tissue-engineered tissue; however, stimulation to enhance tissue maturation and remodeling is still needed...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29482859/magnetic-resonance-imaging-and-functional-outcomes-after-a-polyurethane-meniscal-scaffold-implantation-minimum-5-year-follow-up
#8
Joan C Monllau, Francesco Poggioli, Juan Erquicia, Eduardo Ramírez, Xavier Pelfort, Pablo Gelber, Raúl Torres-Claramunt
PURPOSE: To report the magnetic resonance imaging (MRI) and clinical outcomes at a minimum 5-year follow-up in a series of patients with postmeniscectomy syndrome and treated with a polyurethane scaffold. METHODS: All consecutive patients operated on from September 2008 to February 2011 for either persistent medial or lateral joint line compartmental pain receiving a polyurethane scaffold due to a previous partial meniscus resection with a minimum 5-year follow-up were included...
May 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29460414/tissue-engineering-of-human-knee-meniscus-using-functionalized-and-reinforced-silk-polyvinyl-alcohol-composite-three-dimensional-scaffolds-understanding-the-in-vitro-and-in-vivo-behavior
#9
Mamatha Muraleedharan Pillai, Janarthanan Gopinathan, Rathinasamy Senthil Kumar, Gopal Sathish Kumar, Sivanandam Shanthakumari, Kulasekaran Santosh Sahanand, Amitava Bhattacharyya, Rajendran Selvakumar
Tissue engineered constructs with rapid restoration of mechanical and biological properties remain a challenge, emphasizing the need to develop novel scaffolds. Here, we present a multicomponent composite three-dimensional scaffold structure with biomimetic reinforcement and biomolecule functionalization for meniscus tissue engineering. The scaffold structure was developed using 3:1 silk fibroin (SF) and polyvinyl alcohol (PVA). Autoclaved eggshell membrane (AESM) powder (1-3%w/v) was used as reinforcement to enhance biomechanical properties...
June 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29340746/similar-clinical-outcomes-following-collagen-or-polyurethane-meniscal-scaffold-implantation-a-systematic-review
#10
REVIEW
Darby A Houck, Matthew J Kraeutler, John W Belk, Eric C McCarty, Jonathan T Bravman
PURPOSE: The purpose of this systematic review is to evaluate the current literature in an effort to assess specific clinical outcomes following meniscal scaffold implantation using the two available scaffolds: Collagen Meniscal Implant (CMI) and the Actifit polyurethane meniscal scaffold. METHODS: A systematic review was performed by searching PubMed, Embase, and Cochrane Library to find studies evaluating clinical outcomes of patients undergoing meniscal scaffold implantation...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29308701/the-application-of-electrospinning-used-in-meniscus-tissue-engineering
#11
Mingxue Chen, Shuang Gao, Pei Wang, Yan Li, Weimin Guo, Yu Zhang, Mingjie Wang, Tongguang Xiao, Zengzeng Zhang, Xueliang Zhang, Xiaoguang Jing, Xu Li, Shuyun Liu, Quanyi Guo, Tingfei Xi
Meniscus is a fibrocartilaginous organ to redistribute stress and enhance the stability of knee joint. Meniscus injury is common and still a formidable challenge to orthopedic surgeons. Surgical techniques and allograft transplantation were primary approaches to meniscus repair, but with intrinsic limitations in clinical practice. Tissue engineering is the most promising method to repair meniscus at present. Electrospinning is a method to fabricate fibers in small scale. With different materials and parameters, electrospinning materials could have different mechanical properties, porosity, and orientation, which could mimic architectural features and mechanical properties of native meniscus...
April 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29187260/histological-changes-of-the-meniscus-following-an-osteochondral-lesion
#12
G M Peretti, I Tessaro, L Montanari, U Polito, A Di Giancamillo, M Di Giancamillo, A Marmotti, A Montaruli, E Roveda, L Mangiavini
In the last few years, different tissue engineering strategies have been developed for the repair of osteochondral lesions. When the osteochondral scaffold is implanted on the femoral condyle, the meniscus might be affected by the implant and might undergo a progressive degeneration. The aim of our study is to analyze the morphological changes of the meniscus following an osteochondral lesion and the implant of a biphasic scaffold. A critical osteochondral defect was generated in the medial femoral condyle of mature sheep...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29182439/chondrocyte-based-intraoperative-processing-strategies-for-the-biological-augmentation-of-a-polyurethane-meniscus-replacement
#13
Srujana Vedicherla, Sara Romanazzo, Daniel J Kelly, Conor T Buckley, Cathal J Moran
Purpose/aim of study: Menisectomies account for over 1.5 million surgical interventions in Europe annually, and there is a growing interest in regenerative strategies to improve outcomes in meniscal replacement. The overall objective of this study was to evaluate the role of intraoperatively applied fresh chondrocyte (FC) isolates compared to minced cartilage (MC) fragments, used without cell isolation, to improve bioactivity and tissue integration when combined with a polyurethane replacement. MATERIALS AND METHODS: First, to optimize the intraoperative cell isolation protocol, caprine articular cartilage biopsies were digested with 750 U/ml or 3000 U/ml collagenase type II (ratio of 10 ml per g of tissue) for 30 min, 1 h or 12 h with constant agitation and compared to culture-expanded chondrocytes in terms of matrix deposition when cultured on polyurethane scaffolds...
November 28, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29176654/programmed-biomolecule-delivery-to-enable-and-direct-cell-migration-for-connective-tissue-repair
#14
Feini Qu, Julianne L Holloway, John L Esterhai, Jason A Burdick, Robert L Mauck
Dense connective tissue injuries have limited repair, due to the paucity of cells at the wound site. We hypothesize that decreasing the density of the local extracellular matrix (ECM) in conjunction with releasing chemoattractive signals increases cellularity and tissue formation after injury. Using the knee meniscus as a model system, we query interstitial cell migration in the context of migratory barriers using a novel tissue Boyden chamber and show that a gradient of platelet-derived growth factor-AB (PDGF-AB) expedites migration through native tissue...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29128533/fabrication-of-dense-anisotropic-collagen-scaffolds-using-biaxial-compression
#15
Jared L Zitnay, Shawn P Reese, Garvin Tran, Niloofar Farhang, Robert D Bowles, Jeffrey A Weiss
We developed a new method to manufacture dense, aligned, and porous collagen scaffolds using biaxial plastic compression of type I collagen gels. Using a novel compression apparatus that constricts like an iris diaphragm, low density collagen gels were compressed to yield a permanently densified, highly aligned collagen material. Micro-porosity scaffolds were created using hydrophilic elastomer porogens that can be selectively removed following biaxial compression, with porosity modulated by using different porogen concentrations...
January 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29114640/evolution-of-osteochondritis-dissecans-of-the-lateral-femoral-condyle-combined-with-discoid-meniscus
#16
Erica Bulgheroni, Lorenzo Mattioli, Paolo Bulgheroni
The discoid meniscus is a rare anomaly of the knee that affects mostly the lateral meniscus and is often asymptomatic. The osteochondritis dissecans is a disorder of the subchondral bone and articular cartilage and occurs frequently associated with the discoid lateral meniscus. In the present case, we showed the evolution of this association related to surgical treatment. A patient with lateral knee pain and a magnetic resonance depicting a torn discoid lateral meniscus and osteochondritis dissecans of the lateral femoral condyle was treated with partial meniscectomy and meniscal sutures...
June 2017: Joints
https://www.readbyqxmd.com/read/29062478/mesenchymal-stem-cells-in-human-meniscal-regeneration-a-systematic-review
#17
REVIEW
Ernest Chew, Rohan Prakash, Wasim Khan
BACKGROUND: Stem cell regeneration is the holy grail of meniscal tissue repair. Currently, the best treatment is to preserve the original meniscus but if it fails, a partial meniscectomy is indicated to delay the onset of osteoarthritis. MATERIALS AND METHODS: The authors present a systematic review to determine the up-to-date evidence underlying the use of mesenchymal stem cells for meniscal regeneration in humans. A search was conducted using the electronic databases of MEDLINE/Pubmed, Google scholar, and the Cochrane Collaboration...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29060302/evaluation-of-histological-and-biomechanical-properties-on-engineered-meniscus-tissues-using-sonication-decellularization
#18
A Mardhiyah, M Sha'ban, A Azhim
Sonication decellularization treatment requires proper evaluations on its ability to decellularize meniscus tissue efficiently. This study was done to evaluate the histological and biomechanical properties within meniscus scaffolds. Van Gieson staining was done to evaluate the efficiency of cell removal in meniscus tissues. The consequences of treatment on viscoelastic properties are vital for scaffolds quality and were properly investigated. Picrosirius red and Safranin-O/Fast green staining was carried out to detect extracellular matrix materials (ECM)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29017608/autologous-mesenchymal-stem-cells-or-meniscal-cells-what-is-the-best-cell-source-for-regenerative-meniscus-treatment-in-an-early-osteoarthritis-situation
#19
Johannes Zellner, Girish Pattappa, Matthias Koch, Siegmund Lang, Johannes Weber, Christian G Pfeifer, Michael B Mueller, Richard Kujat, Michael Nerlich, Peter Angele
BACKGROUND: Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising results. However, studies have not found a consensus on the appropriate autologous cell source in a clinical situation, specifically in a challenging degenerative environment. The present study sought to evaluate the appropriate cell source for autologous meniscal repair in a demanding setting of early osteoarthritis...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28963018/temporal-development-of-near-native-functional-properties-and-correlations-with-qmri-in-self-assembling-fibrocartilage-treated-with-exogenous-lysyl-oxidase-homolog-2
#20
Pasha Hadidi, Derek D Cissell, Jerry C Hu, Kyriacos A Athanasiou
Advances in cartilage tissue engineering have led to constructs with mechanical integrity and biochemical composition increasingly resembling that of native tissues. In particular, collagen cross-linking with lysyl oxidase has been used to significantly enhance the mechanical properties of engineered neotissues. In this study, development of collagen cross-links over time, and correlations with tensile properties, were examined in self-assembling neotissues. Additionally, quantitative MRI metrics were examined in relation to construct mechanical properties as well as pyridinoline cross-link content and other engineered tissue components...
December 2017: Acta Biomaterialia
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