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Meniscus scaffold

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https://www.readbyqxmd.com/read/29663192/human-knee-meniscus-regeneration-strategies-a-review-on-recent-advances
#1
REVIEW
Mamatha M Pillai, J Gopinathan, R Selvakumar, Amitava Bhattacharyya
PURPOSE OF REVIEW: Lack of vascularity in the human knee meniscus often leads to surgical removal (total or partial meniscectomy) in the case of severe meniscal damage. However, complete recovery is in question after such removal as the meniscus plays an important role in knee stability. Thus, meniscus tissue regeneration strategies are of intense research interest in recent years. RECENT FINDINGS: The structural complexity and inhomogeneity of the meniscus have been addressed with processing technologies for precisely controlled three dimensional (3D) complex porous scaffold architectures, the use of biomolecules and nanomaterials...
April 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29581987/biochemical-stimulus-based-strategies-for-meniscus-tissue-engineering-and-regeneration
#2
REVIEW
Mingxue Chen, Weimin Guo, Shunag Gao, Chunxiang Hao, Shi Shen, Zengzeng Zhang, Zhenyong Wang, Zehao Wang, Xu Li, Xiaoguang Jing, Xueliang Zhang, Zhiguo Yuan, Mingjie Wang, Yu Zhang, Jiang Peng, Aiyuan Wang, Yu Wang, Xiang Sui, Shuyun Liu, Quanyi Guo
Meniscus injuries are very common and still pose a challenge for the orthopedic surgeon. Meniscus injuries in the inner two-thirds of the meniscus remain incurable. Tissue-engineered meniscus strategies seem to offer a new approach for treating meniscus injuries with a combination of seed cells, scaffolds, and biochemical or biomechanical stimulation. Cell- or scaffold-based strategies play a pivotal role in meniscus regeneration. Similarly, biochemical and biomechanical stimulation are also important. Seed cells and scaffolds can be used to construct a tissue-engineered tissue; however, stimulation to enhance tissue maturation and remodeling is still needed...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29482859/magnetic-resonance-imaging-and-functional-outcomes-after-a-polyurethane-meniscal-scaffold-implantation-minimum-5-year-follow-up
#3
Joan C Monllau, Francesco Poggioli, Juan Erquicia, Eduardo Ramírez, Xavier Pelfort, Pablo Gelber, Raúl Torres-Claramunt
PURPOSE: To report the magnetic resonance imaging (MRI) and clinical outcomes at a minimum 5-year follow-up in a series of patients with postmeniscectomy syndrome and treated with a polyurethane scaffold. METHODS: All consecutive patients operated on from September 2008 to February 2011 for either persistent medial or lateral joint line compartmental pain receiving a polyurethane scaffold due to a previous partial meniscus resection with a minimum 5-year follow-up were included...
February 23, 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29460414/tissue-engineering-of-human-knee-meniscus-using-functionalized-and-reinforced-silk-pva-composite-3d-scaffolds-understanding-the-in-vitro-and-in-vivo-behaviour
#4
Mamatha M Pillai, J Gopinathan, R Senthil Kumar, G Sathish Kumar, S Shanthakumari, K Santosh Sahanand, Amitava Bhattacharyya, R Selvakumar
Tissue engineered constructs with rapid restoration of mechanical and biological properties remains a challenge, emphasizing the need to develop novel scaffolds. Here we present a multi-component composite 3D scaffold structure with biomimetic reinforcement and biomolecule functionalization for meniscus tissue engineering. The scaffold structure was developed using 3:1 silk fibroin (SF) and polyvinyl alcohol (PVA). Autoclaved eggshell membrane (AESM) powder (1-3%w/v) was used as reinforcement to enhance biomechanical properties...
February 20, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29340746/similar-clinical-outcomes-following-collagen-or-polyurethane-meniscal-scaffold-implantation-a-systematic-review
#5
REVIEW
Darby A Houck, Matthew J Kraeutler, John W Belk, Eric C McCarty, Jonathan T Bravman
PURPOSE: The purpose of this systematic review is to evaluate the current literature in an effort to assess specific clinical outcomes following meniscal scaffold implantation using the two available scaffolds: Collagen Meniscal Implant (CMI) and the Actifit polyurethane meniscal scaffold. METHODS: A systematic review was performed by searching PubMed, Embase, and Cochrane Library to find studies evaluating clinical outcomes of patients undergoing meniscal scaffold implantation...
January 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29308701/the-application-of-electrospinning-used-in-meniscus-tissue-engineering
#6
Mingxue Chen, Shuang Gao, Pei Wang, Yan Li, Weimin Guo, Yu Zhang, Mingjie Wang, Tongguang Xiao, Zengzeng Zhang, Xueliang Zhang, Xiaoguang Jing, Xu Li, Shuyun Liu, Quanyi Guo, Tingfei Xi
Meniscus is a fibrocartilaginous organ to redistribute stress and enhance the stability of knee joint. Meniscus injury is common and still a formidable challenge to orthopedic surgeons. Surgical techniques and allograft transplantation were primary approaches to meniscus repair, but with intrinsic limitations in clinical practice. Tissue engineering is the most promising method to repair meniscus at present. Electrospinning is a method to fabricate fibers in small scale. With different materials and parameters, electrospinning materials could have different mechanical properties, porosity, and orientation, which could mimic architectural features and mechanical properties of native meniscus...
April 2018: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/29187260/histological-changes-of-the-meniscus-following-an-osteochondral-lesion
#7
G M Peretti, I Tessaro, L Montanari, U Polito, A Di Giancamillo, M Di Giancamillo, A Marmotti, A Montaruli, E Roveda, L Mangiavini
In the last few years, different tissue engineering strategies have been developed for the repair of osteochondral lesions. When the osteochondral scaffold is implanted on the femoral condyle, the meniscus might be affected by the implant and might undergo a progressive degeneration. The aim of our study is to analyze the morphological changes of the meniscus following an osteochondral lesion and the implant of a biphasic scaffold. A critical osteochondral defect was generated in the medial femoral condyle of mature sheep...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29182439/chondrocyte-based-intraoperative-processing-strategies-for-the-biological-augmentation-of-a-polyurethane-meniscus-replacement
#8
Srujana Vedicherla, Sara Romanazzo, Daniel J Kelly, Conor T Buckley, Cathal J Moran
Purpose/aim of study: Menisectomies account for over 1.5 million surgical interventions in Europe annually, and there is a growing interest in regenerative strategies to improve outcomes in meniscal replacement. The overall objective of this study was to evaluate the role of intraoperatively applied fresh chondrocyte (FC) isolates compared to minced cartilage (MC) fragments, used without cell isolation, to improve bioactivity and tissue integration when combined with a polyurethane replacement. MATERIALS AND METHODS: First, to optimize the intraoperative cell isolation protocol, caprine articular cartilage biopsies were digested with 750 U/ml or 3000 U/ml collagenase type II (ratio of 10 ml per g of tissue) for 30 min, 1 h or 12 h with constant agitation and compared to culture-expanded chondrocytes in terms of matrix deposition when cultured on polyurethane scaffolds...
November 28, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/29176654/programmed-biomolecule-delivery-to-enable-and-direct-cell-migration-for-connective-tissue-repair
#9
Feini Qu, Julianne L Holloway, John L Esterhai, Jason A Burdick, Robert L Mauck
Dense connective tissue injuries have limited repair, due to the paucity of cells at the wound site. We hypothesize that decreasing the density of the local extracellular matrix (ECM) in conjunction with releasing chemoattractive signals increases cellularity and tissue formation after injury. Using the knee meniscus as a model system, we query interstitial cell migration in the context of migratory barriers using a novel tissue Boyden chamber and show that a gradient of platelet-derived growth factor-AB (PDGF-AB) expedites migration through native tissue...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29128533/fabrication-of-dense-anisotropic-collagen-scaffolds-using-biaxial-compression
#10
Jared L Zitnay, Shawn P Reese, Garvin Tran, Niloofar Farhang, Robert D Bowles, Jeffrey A Weiss
We developed a new method to manufacture dense, aligned, and porous collagen scaffolds using biaxial plastic compression of type I collagen gels. Using a novel compression apparatus that constricts like an iris diaphragm, low density collagen gels were compressed to yield a permanently densified, highly aligned collagen material. Micro-porosity scaffolds were created using hydrophilic elastomer porogens that can be selectively removed following biaxial compression, with porosity modulated by using different porogen concentrations...
January 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29114640/evolution-of-osteochondritis-dissecans-of-the-lateral-femoral-condyle-combined-with-discoid-meniscus
#11
Erica Bulgheroni, Lorenzo Mattioli, Paolo Bulgheroni
The discoid meniscus is a rare anomaly of the knee that affects mostly the lateral meniscus and is often asymptomatic. The osteochondritis dissecans is a disorder of the subchondral bone and articular cartilage and occurs frequently associated with the discoid lateral meniscus. In the present case, we showed the evolution of this association related to surgical treatment. A patient with lateral knee pain and a magnetic resonance depicting a torn discoid lateral meniscus and osteochondritis dissecans of the lateral femoral condyle was treated with partial meniscectomy and meniscal sutures...
June 2017: Joints
https://www.readbyqxmd.com/read/29062478/mesenchymal-stem-cells-in-human-meniscal-regeneration-a-systematic-review
#12
REVIEW
Ernest Chew, Rohan Prakash, Wasim Khan
BACKGROUND: Stem cell regeneration is the holy grail of meniscal tissue repair. Currently, the best treatment is to preserve the original meniscus but if it fails, a partial meniscectomy is indicated to delay the onset of osteoarthritis. MATERIALS AND METHODS: The authors present a systematic review to determine the up-to-date evidence underlying the use of mesenchymal stem cells for meniscal regeneration in humans. A search was conducted using the electronic databases of MEDLINE/Pubmed, Google scholar, and the Cochrane Collaboration...
December 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/29060302/evaluation-of-histological-and-biomechanical-properties-on-engineered-meniscus-tissues-using-sonication-decellularization
#13
A Mardhiyah, M Sha'ban, A Azhim
Sonication decellularization treatment requires proper evaluations on its ability to decellularize meniscus tissue efficiently. This study was done to evaluate the histological and biomechanical properties within meniscus scaffolds. Van Gieson staining was done to evaluate the efficiency of cell removal in meniscus tissues. The consequences of treatment on viscoelastic properties are vital for scaffolds quality and were properly investigated. Picrosirius red and Safranin-O/Fast green staining was carried out to detect extracellular matrix materials (ECM)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29017608/autologous-mesenchymal-stem-cells-or-meniscal-cells-what-is-the-best-cell-source-for-regenerative-meniscus-treatment-in-an-early-osteoarthritis-situation
#14
Johannes Zellner, Girish Pattappa, Matthias Koch, Siegmund Lang, Johannes Weber, Christian G Pfeifer, Michael B Mueller, Richard Kujat, Michael Nerlich, Peter Angele
BACKGROUND: Treatment of meniscus tears within the avascular region represents a significant challenge, particularly in a situation of early osteoarthritis. Cell-based tissue engineering approaches have shown promising results. However, studies have not found a consensus on the appropriate autologous cell source in a clinical situation, specifically in a challenging degenerative environment. The present study sought to evaluate the appropriate cell source for autologous meniscal repair in a demanding setting of early osteoarthritis...
October 10, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28963018/temporal-development-of-near-native-functional-properties-and-correlations-with-qmri-in-self-assembling-fibrocartilage-treated-with-exogenous-lysyl-oxidase-homolog-2
#15
Pasha Hadidi, Derek D Cissell, Jerry C Hu, Kyriacos A Athanasiou
Advances in cartilage tissue engineering have led to constructs with mechanical integrity and biochemical composition increasingly resembling that of native tissues. In particular, collagen cross-linking with lysyl oxidase has been used to significantly enhance the mechanical properties of engineered neotissues. In this study, development of collagen cross-links over time, and correlations with tensile properties, were examined in self-assembling neotissues. Additionally, quantitative MRI metrics were examined in relation to construct mechanical properties as well as pyridinoline cross-link content and other engineered tissue components...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28887704/-indication-and-limitations-of-meniscus-replacement
#16
REVIEW
C Stärke, S Kopf, R Becker
BACKGROUND: Meniscal lesions are among the most important musculoskeletal disorders and are the most common indication for knee joint arthroplasty. However, the structural integrity and function is rarely retained, and a loss of tissue results. Thus, there is a huge demand for meniscal replacement options. CURRENT PROCEDURES: Autografts were used in the past but did not fulfill expectations. Meniscus allografts have been developed to be a viable treatment option...
October 2017: Der Orthopäde
https://www.readbyqxmd.com/read/28805136/-the-ovine-model-for-meniscus-tissue-engineering-considerations-of-anatomy-function-implantation-and-evaluation
#17
Andrzej Brzezinski, Salim A Ghodbane, Jay M Patel, Barbara A Perry, Charles J Gatt, Michael G Dunn
Meniscus injuries represent one of the most-common intra-articular knee injuries. The current treatment options include meniscectomy and allograft transplantation, both with poor long-term outcomes. Therefore, there is a need for regenerative techniques to restore meniscal function. To preclinically test scaffolds for meniscus replacement, large animal models need to be established and standardized. This review establishes the anatomical and compositional similarities between human and sheep menisci and provides guidance for implantation and evaluation of such devices...
December 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28783120/platelet-rich-fibrin-facilitates-rabbit-meniscal-repair-by-promoting-meniscocytes-proliferation-migration-and-extracellular-matrix-synthesis
#18
Chin-Chean Wong, Tzong-Fu Kuo, Tsung-Lin Yang, Yang-Hwei Tsuang, Ming-Fang Lin, Chung-Hsun Chang, Yun-Ho Lin, Wing P Chan
Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbit meniscocytes were cultured with different concentrations of PRF-conditioned medium, and were evaluated for their ability to stimulate cell migration, proliferation, and extracellular matrix formation...
August 7, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28772388/an-overview-of-scaffold-design-and-fabrication-technology-for-engineered-knee-meniscus
#19
REVIEW
Jie Sun, Sanjairaj Vijayavenkataraman, Hang Liu
Current surgical treatments for meniscal tears suffer from subsequent degeneration of knee joints, limited donor organs and inconsistent post-treatment results. Three clinical scaffolds (Menaflex CMI, Actifit(®) scaffold and NUsurface(®) Meniscus Implant) are available on the market, but additional data are needed to properly evaluate their safety and effectiveness. Thus, many scaffold-based research activities have been done to develop new materials, structures and fabrication technologies to mimic native meniscus for cell attachment and subsequent tissue development, and restore functionalities of injured meniscus for long-term effects...
January 3, 2017: Materials
https://www.readbyqxmd.com/read/28765605/the-potential-of-using-semitendinosus-tendon-as-autograft-in-rabbit-meniscus-reconstruction
#20
Chenxi Li, Xiaoqing Hu, Qingyang Meng, Xin Zhang, Jingxian Zhu, Linghui Dai, Jin Cheng, Mingjin Zhong, Weili Shi, Bo Ren, Jiying Zhang, Xin Fu, Xiaoning Duan, Yingfang Ao
Since transplantation of meniscal allograft or artificial menisci is limited by graft sources and a series of adverse events, substitution for meniscus reconstruction still needs to be explored. Natural biomaterials, which can provide a unique 3-D microenvironment, remain a promising alternative for tissue engineering. Among them, autograft is a preferred option for its safety and excellent biocompatibility. In this study, we utilized semitendinosus tendon autograft in meniscus reconstruction to investigate its fibrochondrogenic metaplasticity potential and chondroprotective effect...
August 1, 2017: Scientific Reports
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