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Meniscus allograft

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https://www.readbyqxmd.com/read/28805136/the-ovine-model-for-meniscus-tissue-engineering-considerations-of-anatomy-function-implantation-and-evaluation
#1
Andrzej Brzezinski, Salim A Ghodbane, Jay M Patel, Barbara A Perry, Charles J Gatt, Michael G Dunn
Meniscus injuries represent one of the most-common intra-articular knee injuries. The current treatment options include meniscectomy and allograft transplantation, both with poor long-term outcomes. Therefore, there is a need for regenerative techniques to restore meniscal function. In order to pre-clinically test scaffolds for meniscus replacement, large-animal models need to be established and standardized. This review establishes the anatomical and compositional similarities between the human and sheep menisci and provides guidance for implantation and evaluation of such devices...
August 12, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28800919/similar-outcomes-after-osteochondral-allograft-transplantation-in-anterior-cruciate-ligament-intact-and-reconstructed-knees-a-comparative-matched-group-analysis-with-minimum-2-year-follow-up
#2
Dean Wang, Claire D Eliasburg, Tim Wang, Ryan R Fader, Francesca R Coxe, Mollyann D Pais, Riley J Williams
PURPOSE: To compare failure rates and clinical outcomes of osteochondral allograft transplantation (OCA) in anterior cruciate ligament (ACL)-intact versus ACL-reconstructed knees at midterm follow-up. METHODS: After a priori power analysis, a prospective registry of patients treated with OCA for focal chondral lesions ≥2 cm(2) in size with minimum 2-year follow-up was used to match ACL-reconstructed knees with ACL-intact knees by age, sex, and primary chondral defect location...
August 8, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28765605/the-potential-of-using-semitendinosus-tendon-as-autograft-in-rabbit-meniscus-reconstruction
#3
Chenxi Li, Xiaoqing Hu, Qingyang Meng, Xin Zhang, Jingxian Zhu, Linghui Dai, Jin Cheng, Mingjin Zhong, Weili Shi, Bo Ren, Jiying Zhang, Xin Fu, Xiaoning Duan, Yingfang Ao
Since transplantation of meniscal allograft or artificial menisci is limited by graft sources and a series of adverse events, substitution for meniscus reconstruction still needs to be explored. Natural biomaterials, which can provide a unique 3-D microenvironment, remain a promising alternative for tissue engineering. Among them, autograft is a preferred option for its safety and excellent biocompatibility. In this study, we utilized semitendinosus tendon autograft in meniscus reconstruction to investigate its fibrochondrogenic metaplasticity potential and chondroprotective effect...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28753397/lateral-meniscal-allograft-transplant-via-a-medial-approach-leads-to-less-extrusion
#4
Nam-Hong Choi, Jeong-Ki Choi, Bong-Seok Yang, Doe-Hyun Lee, Brian N Victoroff
BACKGROUND: Accurate positioning of the bony bridge is crucial to prevent extrusion of meniscal allografts after transplant. However, oblique or lateralized placement of the bony bridge of the lateral meniscal allograft may occur due to technical error or a limited visual field. The patellar tendon may be an obstacle to approaching the anterior horn of the lateral meniscus, resulting in a laterally placed allograft. Therefore, lateral meniscal transplant through a medial arthrotomy would be an alternative approach...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28719787/in-vivo-performance-of-a-novel-anatomically-shaped-total-meniscal-prosthesis-made-of-polycarbonate-urethane-a-12-month-evaluation-in-goats
#5
Anne C T Vrancken, Gerjon Hannink, Wojciech Madej, Nico Verdonschot, Tony G van Tienen, Pieter Buma
BACKGROUND: Injury or loss of the meniscus generally leads to degenerative osteoarthritic changes in the knee joint. However, the treatment options for symptomatic patients with total meniscectomy are limited. Therefore, we developed a novel, anatomically shaped, total meniscal implant made of polycarbonate urethane. PURPOSE: To evaluate the in vivo performance of this novel total meniscal implant. The assessment particularly focused on the implant's response to long-term physiological loading in a goat model and its chondroprotective capacity in comparison to clinically relevant controls...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28706814/tibial-allograft-transfer-for-medial-tibial-plateau-resurfacing
#6
Jonathan A Godin, Salvatore Frangiamore, Jorge Chahla, Mark E Cinque, Nicholas N DePhillipo, Robert F LaPrade
A large cartilage lesion of the tibial plateau with a deficient meniscus in a young patient is a challenging pathology for the orthopaedic surgeon due to the limited options available. While hemiarthroplasty procedures can be an option, the risk of revision in a young patient is high, and therefore a reconstructive procedure is advocated. The purpose of this Technical Note is to describe our technique for tibial plateau resurfacing, including the preparation and implantation of a medial tibial plateau and medial meniscal allograft, in a patient with a post-traumatic KD-4 knee dislocation with a medial tibial plateau rim fracture, medial meniscus deficiency, and medial tibiofemoral joint subluxation...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28610776/two-stage-late-reconstruction-with-a-fresh-large-osteochondral-shell-allograft-transplantation-flocsat-for-a-large-ostechondral-defect-in-a-non-union-after-a-lateral-tibia-plateau-fracture-2-year-follow-up
#7
C Krettek, J Clausen, M Omar, S Noack, C Neunaber
This is the description of a 58-year-old female patient presenting 8 months after a horse riding accident with significant pain and inability to walk independently. Imaging revealed a large osseous defect of the lateral tibia plateau which was not united posteriorly. The patient refused knee replacement and we developed a patient specific two-step procedure for her. Step 1: Filling of the defect with a large cortico-cancellous autograft from the posterior iliac crest; step 2: Transplantation of a fresh large osteochondral shell allograft (FLOCSAT)...
July 2017: Injury
https://www.readbyqxmd.com/read/28580271/meniscal-allograft-transplantation-with-soft-tissue-in-bone-socket-fixation-arthroscopic-technique-with-technical-pearls
#8
Troy A Roberson, Douglas J Wyland
Meniscal allograft transplantation may slow the progression of degenerative changes in the meniscus-deficient knee. The current literature suggests patients can experience good early to mid-term satisfaction and patient-reported outcomes with reasonable expectations of return to work. More ambitious applications in athletes have also shown good results although long-term data are lacking. Traditionally, meniscal allograft transplantation has been considered an open procedure with incorporation of bone blocks from the allograft source...
April 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28412106/radial-notch-labralization-for-proximal-radioulnar-joint-dysplasia
#9
Enrico Bellato, Shawn W O'Driscoll
BACKGROUND: Chronic posterior subluxation or dislocation of the radial head is uncommon and difficult to treat. To restore radiocapitellar alignment, procedures such as deepening of the notch using a high-speed burr have been described, but they can result in cartilage damage. We hypothesized that a radial notch labralization using soft tissue could improve radiocapitellar tracking without violating the joint surface. METHODS: A radial notch labralization was performed in 3 patients with chronic posterior subluxation of the radial head and developmental dysplasia of the radial notch in the setting of complex recurrent instability of the elbow...
July 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28383764/risk-factors-for-radiographic-joint-space-narrowing-and-patient-reported-outcomes-of-post-traumatic-osteoarthritis-after-acl-reconstruction-data-from-the-moon-cohort
#10
REVIEW
Morgan H Jones, Kurt P Spindler
The Multicenter Orthopaedic Outcomes Network (MOON) is an NIH-funded prospective, longitudinal cohort of over 3,500 patients who have undergone anterior cruciate ligament reconstruction (ACLR) by 14 sports medicine surgeons at 7 academic medical centers. Patient reported outcome questionnaires (PRO's) are completed at baseline and multiple timepoints after surgery, and a nested cohort of patients return for radiographs to assess the development of joint space changes. We review the risk factors for worse patient reported outcomes, the predictors of clinically significant symptoms of post-traumatic osteoarthritis (PTOA), and the factors associated with more radiographic joint space narrowing...
July 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28364144/current-advances-in-the-development-of-natural-meniscus-scaffolds-innovative-approaches-to-decellularization-and-recellularization
#11
REVIEW
Yunbin Chen, Jiaxin Chen, Zeng Zhang, Kangliang Lou, Qi Zhang, Shengyu Wang, Jinhu Ni, Wenyue Liu, Shunwu Fan, Xianfeng Lin
The increasing rate of injuries to the meniscus indicates the urgent need to develop effective repair strategies. Irreparably damaged menisci can be replaced and meniscus allografts represent the treatment of choice; however, they have several limitations, including availability and compatibility. Another approach is the use of artificial implants but their chondroprotective activities are still not proved clinically. In this situation, tissue engineering offers alternative natural decellularized extracellular matrix (ECM) scaffolds, which have shown biomechanical properties comparable to those of native menisci and are characterized by low immunogenicity and promising regenerative potential...
March 31, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28351490/high-meniscal-slope-angle-as-a-risk-factor-for-meniscal-allograft-extrusion
#12
P Łuczkiewicz, K Daszkiewicz, J Chróścielewski, W Witkowski, L Kuik
A meniscal graft extrusion is still an unresolved problem that affects most patients after a meniscal transplantation. Despite the advances in surgical techniques, together with the improved methods for a meniscal allograft sizing, success is only observed in up to 75% of patients after they experience a meniscal allograft transplantation. Because a meniscal extrusion is associated with a cartilage deterioration and the progression of osteoarthritis there is a great interest in how to prevent this phenomenon...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28345410/transplantation-of-chemically-processed-decellularized-meniscal-allografts
#13
Kolja Gelse, Ludwig Körber, Martin Schöne, Kay Raum, Peter Koch, Milena Pachowsky, Götz Welsch, Roman Breiter
Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts were transplanted into the knee joints of sheep that were treated by lateral meniscectomy. Joints treated by meniscectomy only and untreated joints served as controls. The joints were analyzed morphologically 6 and 26 weeks after surgery by the macroscopical and histological OARSI (Osteoarthritis Research Society International) score...
April 2017: Cartilage
https://www.readbyqxmd.com/read/28231642/meniscal-transplants-and-scaffolds-a-systematic-review-of-the-literature
#14
REVIEW
Sean Dangelmajer, Filippo Familiari, Roberto Simonetta, Mehmet Kaymakoglu, Gazi Huri
The reported incidence of meniscal tears is approximately 61 per 100,000. In instances where preservation of the native meniscus is no longer a feasible option, meniscal allograft transplantation (MAT) and implants or scaffolds may be considered. The goal of this review was to compare the success and failure rates of two techniques, MAT and meniscal scaffolds, and make an inference which treatment is more preferable at the present time and future. Studies that met inclusion criteria were assessed for technique used, type of transplant used, number of procedures included in the study, mean age of patients, mean follow-up time, number of failures, failure rate, and reported reoperation rate...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28203596/intra-articular-implantation-of-mesenchymal-stem-cells-part-2-a-review-of-the-literature-for-meniscal-regeneration
#15
Matthew J Kraeutler, Justin J Mitchell, Jorge Chahla, Eric C McCarty, Cecilia Pascual-Garrido
Knee osteoarthritis (OA) after partial or total meniscectomy is a prevalent issue that patients must face. Various methods of replacing meniscal tissue have been studied to avoid this progression, including meniscal allograft transplantation, meniscal scaffolds, and synthetic meniscus replacement. Studies have shown that meniscal scaffolds may improve symptoms but have not been shown to prevent progression of OA. Recently, mesenchymal stem cells (MSCs) have been proposed as a possible biological therapy for meniscal regeneration...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28161573/chondrogenically-primed-tonsil-derived-mesenchymal-stem-cells-encapsulated-in-riboflavin-induced-photocrosslinking-collagen-hyaluronic-acid-hydrogel-for-meniscus-tissue-repairs
#16
Rachel H Koh, Yinji Jin, Byung-Jae Kang, Nathaniel S Hwang
Current meniscus tissue repairing strategies involve partial or total meniscectomy, followed by allograft transplantation or synthetic material implantation. However, allografts and synthetic implants have major drawbacks such as the limited supply of grafts and lack of integration into host tissue, respectively. In this study, we investigated the effects of conditioned medium (CM) from meniscal fibrochondrocytes and TGF-β3 on tonsil-derived mesenchymal stem cells (T-MSCs) for meniscus tissue engineering. CM-expanded T-MSCs were encapsulated in riboflavin-induced photocrosslinked collagen-hyaluronic acid (COL-RF-HA) hydrogels and cultured in chondrogenic medium containing TGF-β3...
February 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28056527/osteochondral-allograft-transplantation-of-the-knee-analysis-of-failures-at-5-years
#17
Rachel M Frank, Simon Lee, David Levy, Sarah Poland, Maggie Smith, Nina Scalise, Gregory L Cvetanovich, Brian J Cole
BACKGROUND: Osteochondral allograft transplantation (OAT) is being performed with increasing frequency, and the need for reoperations is not uncommon. PURPOSE: To quantify survival for OAT and report findings at reoperations. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: A review of prospectively collected data of 224 consecutive patients who underwent OAT by a single surgeon with a minimum follow-up of 2 years was conducted...
March 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27916187/editorial-commentary-which-factors-influence-osteoarthritic-progression-after-meniscal-allograft-transplantation
#18
EDITORIAL
Shinichi Yoshiya
In a recent article, the authors conducted radiologic follow-up evaluation for knees that had undergone isolated meniscal allograft transplantation. Postoperative osteoarthritic progression was observed in 45% of the knees. Among the demographic and clinical characteristics, medial meniscus allograft transplantation was identified as a significant risk factor for osteoarthritic progression. However, we still do not know whether meniscal allograft transplantation can prevent or retard the subsequent progression of osteoarthritis...
December 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27909660/osteochondral-proximal-tibial-and-lateral-meniscal-allograft-transplant
#19
Guillem Gonzalez-Lomas, Andrew P Dold, Daniel J Kaplan, David J Fralinger, Laith Jazrawi
Knee pain in young, active patients with meniscus-deficient knees and articular cartilage damage can present a challenge to treatment. Meniscal allograft transplantation (MAT) has shown good clinical results as treatment for meniscus deficiency; however, worse outcomes have been observed in patients with significant chondral damage. The development of chondral restorative techniques such as osteochondral allograft transplantation (OCA) has expanded the population of patients who may benefit from MAT. We present a case of proximal tibial osteochondral and lateral meniscal allograft transplant...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27793202/enhanced-cellular-infiltration-of-human-adipose-derived-stem-cells-in-allograft-menisci-using-a-needle-punch-method
#20
Rachel C Nordberg, Adisri Charoenpanich, Christopher E Vaughn, Emily H Griffith, Matthew B Fisher, Jacqueline H Cole, Jeffrey T Spang, Elizabeth G Loboa
BACKGROUND: The meniscus plays a crucial role in knee joint stability, load transmission, and stress distribution. Meniscal tears are the most common reported knee injuries, and the current standard treatment for meniscal deficiency is meniscal allograft transplantation. A major limitation of this approach is that meniscal allografts do not have the capacity to remodel and maintain tissue homeostasis due to a lack of cellular infiltration. The purpose of this study was to provide a new method for enhanced cellular infiltration in meniscal allografts...
October 28, 2016: Journal of Orthopaedic Surgery and Research
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