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https://www.readbyqxmd.com/read/29687871/cell-therapy-of-a-knee-osteoarthritis-rat-model-using-precartilaginous-stem-cells
#1
M-P Fan, M Si, B-J Li, G-H Hu, Y Hou, W Yang, L Liu, B Tang, L Nie
OBJECTIVE: To explore the effect and mechanism of precartilaginous stem cells (PSCs) engraftment-inducing tissue repair in a knee osteoarthritis (OA) rat model. MATERIALS AND METHODS: Knee osteoarthritis (OA) model was constructed in Sprague Dawley (SD) rats by partial removal of the medial meniscus of the right knee. PSCs were engrafted by injecting precartilaginous stem cells (PSCs) into the right knee cavity. At 4 and 8 weeks after model construction, the serum levels of interleukine (IL)-1β, tumor necrosis factor (TNF)-α, and IL-6 were assessed using enzyme-linked immunosorbent assay (ELISA)...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29668032/presence-of-meniscus-tear-alters-gene-expression-profile-of-anterior-cruciate-ligament-tears
#2
Robert H Brophy, Marcus A Rothermich, Eric D Tycksen, Lei Cai, Muhammad Farooq Rai
Anterior cruciate ligament (ACL) tears occur in isolation or in tandem with other intra-articular injuries such as meniscus tears. The impact of injury pattern on the molecular biology of the injured ACL is unknown. Here, we tested the hypothesis that the biological response of the ACL to injury varies based on the presence or absence of concomitant meniscus tear. We performed RNA-seq on 28 ACL tears remnants (12 isolated, 16 combined). In total, 16,654 transcripts were differentially-expressed between isolated and combined injury groups at false-discovery-rate of 0...
April 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29665604/-foreign-material-free-anterior-cruciate-ligament-repair-with-hamstring-graft-felmet-technique
#3
Marc Chmielnicki, Wolfram Siebert, Axel Prokop
Rupture of the anterior cruciate ligament (ACL) is a common sports injury. Shear forces can damage the articular cartilage and lead to early osteoarthritis. Ligamentary stabilisation of the knee is necessary. Today, arthroscopic ACL repair is a standard knee procedure. Transplant fixation is often performed using implants, e.g. interference screws. The foreign material-free procedure using the Felmet technique enables biological, mechanically stable fixation of the hamstring tendon graft. We demonstrate the surgical technique, including meniscus suture and a video case study...
April 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29665134/the-role-of-bmp2-in-the-maturation-and-maintenance-of-the-murine-knee-joint
#4
Laura W Gamer, Steven Pregizer, Jackson Gamer, Marina Feigenson, Andreia Ionescu, Qing Li, Lin Han, Vicki Rosen
Bone morphogenetic proteins (BMPs) are key regulators of skeletal development, growth and repair. While BMP signaling is required for synovial joint formation and is also involved in preserving joint function after birth, the role of specific BMP ligands in adult joint homeostasis remains unclear. The purpose of this study was to define the role of Bmp2 in the morphogenesis and maintenance of the knee joint. To do this, we first created Bmp2-LacZ and Gdf5-LacZ knock-in mice and compared their expression patterns in the developing and postnatal murine knee joint...
April 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29663192/human-knee-meniscus-regeneration-strategies-a-review-on-recent-advances
#5
REVIEW
Mamatha M Pillai, J Gopinathan, R Selvakumar, Amitava Bhattacharyya
PURPOSE OF REVIEW: Lack of vascularity in the human knee meniscus often leads to surgical removal (total or partial meniscectomy) in the case of severe meniscal damage. However, complete recovery is in question after such removal as the meniscus plays an important role in knee stability. Thus, meniscus tissue regeneration strategies are of intense research interest in recent years. RECENT FINDINGS: The structural complexity and inhomogeneity of the meniscus have been addressed with processing technologies for precisely controlled three dimensional (3D) complex porous scaffold architectures, the use of biomolecules and nanomaterials...
April 16, 2018: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/29662913/high-rate-of-missed-lateral-meniscus-posterior-root-tears-on-preoperative-magnetic-resonance-imaging
#6
Aaron J Krych, Isabella T Wu, Vishal S Desai, Naveen S Murthy, Mark S Collins, Daniel B F Saris, Bruce A Levy, Michael J Stuart
Background: Lateral meniscus posterior root tears (LMPRTs), if left untreated, can cause devastating effects to the knee, with rapid articular cartilage degeneration and loss of the meniscus as a secondary stabilizer. Detection and surgical repair of these defects have been linked to favorable outcomes, but preoperative identification of LMPRTs continues to be challenging. Purpose: To determine the rate of LMPRTs diagnosed preoperatively on magnetic resonance imaging (MRI) in a consecutive series of arthroscopically confirmed LMPRTs...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29648924/operative-treatment-of-isolated-meniscus-injuries-in-adolescent-patients-a-meta-analysis-and-review
#7
Gina M Mosich, Virginia Lieu, Edward Ebramzadeh, Jennifer J Beck
CONTEXT: With the rise in sports participation and increased athleticism in the adolescent population, there is an ever-growing need to better understand adolescent meniscus pathology and treatment. OBJECTIVE: To better understand the operative management of meniscus tears in the adolescent population. DATA SOURCES: A systematic review of PubMed (MEDLINE) and Google Scholar was performed for all archived years. STUDY SELECTION: Studies that reported on isolated meniscus tears in adolescent patients (age, 10-19 years) were included...
April 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29626617/dynamic-sonographic-visualization-of-an-occult-posterior-lateral-meniscocapsular-separation-a-case-report
#8
Allison Schroeder, Volker Musahl, Christopher Urbanek, Kentaro Onishi
Meniscocapsular separation describes detachment of the meniscus from the knee joint capsule. Diagnosis is challenging with conventional examination and imaging methods. We report a case of an 18-year-old female softball catcher with unrevealing MRI despite continued left knee locking and discomfort with deep squatting. Meniscocapsular separation was revealed only on dynamic sonographic exam, where knee flexion revealed a 3.1 mm gap that developed between the capsule and peripheral meniscus. Arthroscopy confirmed the sonographic findings, and repair resulted in complete resolution of symptoms...
April 4, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/29622245/editorial-commentary-we-know-we-need-to-fix-knee-meniscal-radial-root-tears-but-how-best-to-perform-the-repairs
#9
EDITORIAL
Robert F LaPrade
The present work further contributes to building the base of the research pyramid by noting the importance of repairing knee meniscal radial root tears. Because of the extensive biomechanical studies that have now been published on the restoration of joint mechanics and with what I believe results in a higher likelihood of an improved healing environment with securing the meniscus root tear down to bone, I would strongly recommend that when one does see a meniscus root tear that the transtibial pullout root repair technique be considered over a side-to-side repair...
April 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29614071/annual-trends-in-arthroscopic-meniscus-surgery-analysis-of-a-national-database-in-japan
#10
Manabu Kawata, Yusuke Sasabuchi, Shuji Taketomi, Hiroshi Inui, Hiroki Matsui, Kiyohide Fushimi, Hirotaka Chikuda, Hideo Yasunaga, Sakae Tanaka
BACKGROUND: The importance of meniscus preservation is widely recognized. There have been a few studies describing trends in meniscectomy and meniscus repair in the United States; however, they presented differing results. We reported annual trends in meniscus surgery, using a national database in Japan. METHODS: We interrogated the Diagnosis Procedure Combination database, which represents approximately half of all hospital admissions in Japan. We included the patients who underwent meniscectomy and meniscus repair between July 2007 and March 2015...
2018: PloS One
https://www.readbyqxmd.com/read/29607459/the-role-of-meniscal-repair-for-prevention-of-early-onset-of-osteoarthritis
#11
REVIEW
Johannes Weber, Matthias Koch, Peter Angele, Johannes Zellner
BACKGROUND: The meniscus plays an important role in the integrity of the knee joint. Therefore, meniscus tissue preserving techniques for the therapy of meniscus injuries seem to be reasonable. One of the important questions is whether meniscal repair can prevent the knee joint from early onset of osteoarthritis. METHODS: According to the review of the current literature, the principles of a successful meniscal repair are explained and the functional outcome and its impact on the prevention of osteoarthritis are analyzed in this article...
April 2, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29600217/double-posterior-cruciate-ligament-sign-on-magnetic-resonance-imaging-imaging-variants-mimics-and-clinical-implications
#12
Raju Vaishya, Vipul Vijay, Abhishek Vaish, Amit K Agarwal, Nitin P Ghonge
Introduction: Double posterior cruciate ligament (PCL) sign is a sign on magnetic resonance imaging (MRI) which is suggestive of a bucket- handle tear (BHT) of the meniscus. We undertook this study to assess the presence of a double PCL sign and its correlation with arthroscopic findings. We also discussed the various mimics and variants of the double PCL sign. Case Report: All the patients with a double PCL sign on the MRI and who underwent knee arthroscopy between January 2012 and December 2016 (total of 5 cases, 4 males and one female) were included in the study...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29571265/variability-of-online-available-physical-therapy-protocols-from-academic-orthopedic-surgery-programs-for-arthroscopic-meniscus-repair
#13
Steven F DeFroda, Steven L Bokshan, Alex Boulos, Brett D Owens
OBJECTIVES: To evaluate the variability of arthroscopic meniscus repair rehabilitation protocols. METHODS: Arthroscopic meniscus repair rehabilitation protocols from Accreditation Council for Graduate Medical Education (ACGME) accredited orthopedic surgery programs available online were included for review. Data collection was performed to evaluate recommended weight bearing status and immobilization as well as the presence or absence of recommended therapies, goals for progression of range of motion, functional milestones, and activity initiation time points within each protocol...
March 23, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29570766/arthroscopic-repair-of-chronic-tears-of-the-anterior-horn-of-the-lateral-meniscus-that-includes-covering-the-lesion-with-an-infrapatellar-pedicle-fat-flap
#14
Zhu Dai, Zhiwei Chen, Ying Liao, Zhengwu Tang, Juncheng Cui, Zhibin Tang
This study analyzed the efficacy and safety of arthroscopic outside-in repair of the anterior horn of the lateral meniscus that includes covering the lesion with an infrapatellar pedicle fat flap in patients with chronic tears. This retrospective study reviewed 87 patients with chronic tears of the anterior horn of the lateral meniscus who underwent arthroscopic outside-in repair, which included covering the lesion with an infrapatellar pedicle fat flap (group A, n=45) or not (group B, n=42). The 2 groups were similar in terms of age, sex, body mass index, and disease duration...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29564055/medial-meniscal-root-repair-using-curved-guide-and-soft-suture-anchor
#15
Su-Keon Lee, Bong-Seok Yang, Byeong-Mun Park, Ji-Ung Yeom, Ji-Hyeon Kim, Jeong-Seok Yu
Medial meniscal root tears have been repaired using various methods. Arthroscopic all-inside repair using a suture anchor is one of the popular methods. However, insertion of the suture anchor into the proper position at the posterior root of the medial meniscus is technically difficult. Some methods have been reported to facilitate suture anchor insertion through a high posteromedial portal, a posterior trans-septal portal, or a medial quadriceptal portal. Nevertheless, many surgeons still have difficulty during anchor insertion...
March 2018: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/29563703/rapid-macular-hole-formation-and-closure-in-a-vitrectomized-eye-following-rhegmatogenous-retinal-detachment-repair
#16
Ratnesh Ranjan, George Joseph Manayath, Udayasree Avadhani, Venkatapathy Narendran
The development of a full-thickness macular hole (FTMH) after pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment (RRD) repair is a rare occurrence. We report the first case of rapid MH formation with internal limiting membrane (ILM)-like hyper-reflective bridging membrane under silicone oil (SO) meniscus, noted on the first postoperative day (POD) postvitrectomy for RRD. A 57-year-old man presented with best-corrected visual acuity (BCVA) of perception of light with immature cataract and total RRD in the left eye...
January 2018: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/29556892/successful-anterior-cruciate-ligament-reconstruction-and-meniscal-repair-in-osteogenesis-imperfecta
#17
Jae-Young Park, Tae-Joon Cho, Myung Chul Lee, Hyuk-Soo Han
A case of anterior cruciate ligament (ACL) reconstruction with meniscal repair in an osteogenesis imperfecta patient is reported. A 24-year-old female with osteogenesis imperfecta type 1a suffered from a valgus extension injury resulting in tear of ACL and medial meniscus. She underwent an arthroscopic-assisted ACL reconstruction and medial meniscus repair. Meniscal tear at the menisco-capsular junction of the posterior horn of medial meniscus was repaired with three absorbable sutures via inside-out technique...
March 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29555076/impacts-of-maturation-on-the-micromechanics-of-the-meniscus-extracellular-matrix
#18
Qing Li, Chao Wang, Biao Han, Feini Qu, Hao Qi, Christopher Y Li, Robert L Mauck, Lin Han
To elucidate how maturation impacts the structure and mechanics of meniscus extracellular matrix (ECM) at the length scale of collagen fibrils and fibers, we tested the micromechanical properties of fetal and adult bovine menisci via atomic force microscopy (AFM)-nanoindentation. For circumferential fibers, we detected significant increase in the effective indentation modulus, Eind , with age. Such impact is in agreement with the increase in collagen fibril diameter and alignment during maturation, and is more pronounced in the outer zone, where collagen fibrils are more aligned and packed...
March 9, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29542287/current-concepts-in-meniscus-tissue-engineering-and-repair
#19
REVIEW
Bahar Bilgen, Chathuraka T Jayasuriya, Brett D Owens
The meniscus is the most commonly injured structure in the human knee. Meniscus deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal mechanical forces, and replacement strategies for this structure have lagged behind other tissue engineering endeavors. The challenges include the complex 3D structure with individualized size parameters, the significant compressive, tensile and shear loads encountered, and the poor blood supply. In this progress report, a review of the current clinical treatments for different types of meniscal injury is provided...
March 15, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29525029/knee-meniscus-injuries-common-problems-and-solutions
#20
REVIEW
Matthew H Blake, Darren L Johnson
The rates of arthroscopic meniscus repair continue to increase with excellent reported outcomes. Complications, sometimes catastrophic, following meniscus repair may occur. The rate of postoperative complications may be reduced by adequate diagnosis, appropriate patient selection, meniscus repair selection, surgical techniques, and postoperative management. When complications occur, the provider must identify and take steps to rectify as well as prevent further complications from occurring. The purpose of this article is to detail the common diagnostic, technical, and postoperative pitfalls that may result in poor patient outcomes...
April 2018: Clinics in Sports Medicine
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