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https://www.readbyqxmd.com/read/28733196/proteasome-subunit-beta-type-1-p11a-polymorphism-is-a-new-prognostic-marker-in-multiple-myeloma
#1
Gergely Varga, Gábor Mikala, Katalin Piroska Kiss, Éva Kosóczki, Edit Szabó, Nóra Meggyesi, Katalin Balassa, Petra Kövy, Bálint Tegze, Gergely Szombath, Attila Tordai, Hajnalka Andrikovics, László Homolya, Tamás Masszi
BACKGROUND: Proteasome subunit beta type 1 (PSMB1) rs12717 polymorphism, a single nucleotide polymorphism with unknown functional effect, was recently reported to influence response to bortezomib-based therapy in follicular lymphoma. PATIENTS AND METHODS: We retrospectively analyzed the prognostic impact of this polymorphism in 211 consecutively diagnosed multiple myeloma cases, and performed in vitro experiments to look into its functional consequences. RESULTS: On univariate analysis, patients carrying the variant G allele showed significantly shorter progression-free survival (PFS) with a pattern suggestive of a gene-dose effect (PFS 26...
June 30, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28729625/stable-isotopes-reveal-diet-shift-from-pre-extinction-to-reintroduced-przewalski-s-horses
#2
Petra Kaczensky, Martina Burnik Šturm, Mikhail V Sablin, Christian C Voigt, Steve Smith, Oyunsaikhan Ganbaatar, Boglarka Balint, Chris Walzer, Natalia N Spasskaya
The Przewalski's horse (Equus ferus przewalskii), the only remaining wild horse within the equid family, is one of only a handful of species worldwide that went extinct in the wild, was saved by captive breeding, and has been successfully returned to the wild. However, concerns remain that after multiple generations in captivity the ecology of the Przewalski's horse and / or the ecological conditions in its former range have changed in a way compromising the species' long term survival. We analyzed stable isotope chronologies from tail hair of pre-extinction and reintroduced Przewalski's horses from the Dzungarian Gobi and detected a clear difference in the isotopic dietary composition...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28716112/psychosocial-interventions-for-managing-occupational-stress-and-burnout-among-medical-doctors-a-systematic-review
#3
Bonnie A Clough, Sonja March, Raymond J Chan, Leanne M Casey, Rachel Phillips, Michael J Ireland
BACKGROUND: Occupational stress and burnout are highly prevalent among medical doctors and can have adverse effects on patient, doctor, and organisational outcomes. The purpose of the current study was to review and evaluate evidence on psychosocial interventions aimed at reducing occupational stress and burnout among medical doctors. METHOD: A systematic review was conducted for original research articles reporting on psychosocial interventions targeting occupational stress or burnout among medical doctors, published in the English language, and with data collected at a minimum of two time points...
July 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28710556/visual-mismatch-negativity-vmmn-for-low-and-high-level-deviances-a-control-study
#4
Domonkos File, Bálint File, Flóra Bodnár, István Sulykos, Krisztina Kecskés-Kovács, István Czigler
The aim of our studies was to separate the effects of violating a sequential rule (genuine visual mismatch negativity; gvMMN) from the decreased activity in response to repeated stimuli (stimulus-specific adaptation; SSA) for simple and more complex stimuli. To accomplish this goal, different control procedures were applied with the aim of finding the correct control for vMMN studies. Event-related brain electric activity (ERPs) was measured in response to nonattended visual stimuli that were presented either in an oddball manner or in various control sequences...
July 14, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28708356/-what-remains-of-our-balints
#5
Régis Marion-Veyron, Konstantinos Tzartzas, Michael Saraga
In addition to providing psychiatric care to patients with somatic diseases, liaison psychiatry plays a role in the teaching of the relational aspects of medical practice. This series of three articles offers a critical reflection on this topic and examples of educational programs developed at Lausanne University Hospital. In the Department of Ambulatory Care and Community Medicine, an intervention inspired by Balint groups offers to residents in general internal medicine the possibility of working through their clinical experiences and their evolving professional identity...
February 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28700266/resources-for-the-provision-of-nutrition-support-to-children-in-educational-environments
#6
Mandy L Corrigan, Shirley Huang, Ann Weaver, David Keeler, Katina Rahe, Jane Balint, Michelle Marti, Brandis Goodman, Traci Nagy, Victoria DeLano, Betty Bond
The use of nutrition support outside of institutional settings has contributed to maintaining the health, well-being, and nutrition status of many medically complex children. As these children grow and enter educational settings, there is a need for awareness of the care that these children require for nutrition support therapy. This document is designed to raise awareness to these needs, provide best practice educational resources for those involved in the supervision or provision of nutrition support to children in an educational environment, and promote safe and effective care...
July 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28691921/application-of-the-lany-zunger-polaron-correction-for-calculating-surface-charge-trapping
#7
Meisam Farzalipour Tabriz, Bálint Aradi, Thomas Frauenheim, Peter Deak
Defect calculations, using density functional theory in a local or semi-local approximation, in transition metal oxides are severely handicapped by the electron self-interaction error. The underestimation of the band gap may cause incorrect occupation of defect states and wrong formation energies, and the underestimated localization of the states disfavors the formation of small polarons. These problems can be avoided by using higher level approximations (GW or a correctly chosen hybrid functional), but those methods are computationally too expensive to be used for calculating surface defects in a periodic slab model...
July 10, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28688391/crf-pepico-double-velocity-map-imaging-photoelectron-photoion-coincidence-spectroscopy-for-reaction-kinetics-studies
#8
Bálint Sztáray, Krisztina Voronova, Krisztián G Torma, Kyle J Covert, Andras Bodi, Patrick Hemberger, Thomas Gerber, David L Osborn
Photoelectron photoion coincidence (PEPICO) spectroscopy could become a powerful tool for the time-resolved study of multi-channel gas phase chemical reactions. Toward this goal, we have designed and tested electron and ion optics that form the core of a new PEPICO spectrometer, utilizing simultaneous velocity map imaging for both cations and electrons, while also achieving good cation mass resolution through space focusing. These optics are combined with a side-sampled, slow-flow chemical reactor for photolytic initiation of gas-phase chemical reactions...
July 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28663547/explicit-instructions-and-consolidation-promote-rewiring-of-automatic-behaviors-in-the-human-mind
#9
Emese Szegedi-Hallgató, Karolina Janacsek, Teodóra Vékony, Lia Andrea Tasi, Leila Kerepes, Emőke Adrienn Hompoth, Anna Bálint, Dezső Németh
One major challenge in human behavior and brain sciences is to understand how we can rewire already existing perceptual, motor, cognitive, and social skills or habits. Here we aimed to characterize one aspect of rewiring, namely, how we can update our knowledge of sequential/statistical regularities when they change. The dynamics of rewiring was explored from learning to consolidation using a unique experimental design which is suitable to capture the effect of implicit and explicit processing and the proactive and retroactive interference...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28662781/do-not-resuscitate-orders-in-the-perioperative-environment-a%C3%A2-multidisciplinary-quality-improvement-project
#10
Malgorzata Baumann, Shelley Killebrew, Katherine Zimnicki, Katherine Balint
Do-not-resuscitate (DNR) orders in the perioperative environment must be managed according to national and institutional guidelines. Health care professionals, including perioperative nurses, may be unfamiliar with the guidelines and unsure of their role in reevaluating a DNR order. We conducted a multidisciplinary quality improvement project at a metropolitan community hospital that aimed to improve health care providers' compliance with the institutional policy, nursing involvement in DNR reevaluation, and communication between providers...
July 2017: AORN Journal
https://www.readbyqxmd.com/read/28657740/miscibility-and-thermodynamics-of-mixing-of-different-models-of-formamide-and-water-in-computer-simulation
#11
Bálint Kiss, Balázs Fábián, Abdenacer Idrissi, Milán Szőri, Pál Jedlovszky
The thermodynamic changes that occur upon mixing five models of formamide and three models of water, including the miscibility of these model combinations itself, is studied by performing Monte Carlo computer simulations using an appropriately chosen thermodynamic cycle and the method of thermodynamic integration. The results show that the mixing of these two components is close to the ideal mixing, as both the energy and entropy of mixing turn out to be rather close to the ideal term in the entire composition range...
July 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28637499/diagnostic-relevance-of-urinary-steroid-profiles-on-ovarian-granulosa-cell-tumors-two-case-reports
#12
Anita Bufa, Nelli Farkas, Zsolt Preisz, Viktória Poór, Csilla Páger, Sándor Szukits, Bálint Farkas, Péter Miklós Gőcze
BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell tumor often happens after 5 years. CASE PRESENTATION: We describe two cases of postmenopausal women with adult-type granulosa cell tumors of the ovary. Patient 1 is a 49-year-old European woman with a recurrent tumor; patient 2 is a 55-year-old European woman without recurrence of tumor...
June 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28632738/correction-phenotypic-heterogeneity-promotes-adaptive-evolution
#13
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28621642/spectrum-and-antibiotic-resistance-of-uropathogens-between-2004-and-2015-in-a-tertiary-care-hospital-in-hungary
#14
András Magyar, Béla Köves, Károly Nagy, András Dobák, Vinodh Kumar Adithyaa Arthanareeswaran, Péter Bálint, Florian Wagenlehner, Péter Tenke
PURPOSE: Surveillance of the bacterial spectrum and antibiotic-resistance patterns of locally occurring uropathogens is essential to serve as a basis for empirical treatment of urinary tract infections (UTIs), as antibiotic-resistance rates may vary geographically with significant differences between countries and regions, and with time. METHODOLOGY: We retrospectively analysed all urine samples taken in the department of urology in a tertiary care hospital in Hungary from January 2004 to December 2015...
June 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28621190/-watermelon-stomach-can-be-the-cause-of-severe-gastrointestinal-bleeding
#15
István Sugár, Zoltán Ráth, Pál Ondrejka, Zsolt Iványi, Bálint Scheich, Judit Várkonyi
Irregular vascular dilatation in the antrum or the cardia of the stomach can be the cause of severe gastrointestinal bleeding. The first term for it - in the beginning of the 50's of the previous century - was GAVE (Gastric Antral Vascular Ectasia) since at that time no similar phenomenon had been registered before. A quarter of a century later, after publishing a few cases, a witty internist described it as "watermelon stomach" because the macroscopic picture is similarly looking as the aforesaid fruit's appearing...
June 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28618599/grain-coarsening-in-two-dimensional-phase-field-models-with-an-orientation-field
#16
Bálint Korbuly, Tamás Pusztai, Hervé Henry, Mathis Plapp, Markus Apel, László Gránásy
In the literature, contradictory results have been published regarding the form of the limiting (long-time) grain size distribution (LGSD) that characterizes the late stage grain coarsening in two-dimensional and quasi-two-dimensional polycrystalline systems. While experiments and the phase-field crystal (PFC) model (a simple dynamical density functional theory) indicate a log-normal distribution, other works including theoretical studies based on conventional phase-field simulations that rely on coarse grained fields, like the multi-phase-field (MPF) and orientation field (OF) models, yield significantly different distributions...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28611956/comparative-genomic-and-phylogenetic-analysis-of-a-shiga-toxin-producing-shigella-sonnei-stss-strain
#17
Domonkos Sváb, Balázs Bálint, Bálint Vásárhelyi, Gergely Maróti, István Tóth
Shigella strains are important agents of bacillary dysentery, and in recent years Shigella sonnei has emerged as the leading cause of shigellosis in industrialized and rapidly developing countries. More recently, several S. sonnei and Shigella flexneri strains producing Shiga toxin (Stx) have been reported from sporadic cases and from an outbreak in America. In the present study we aimed to shed light on the evolution of a recently identified Shiga toxin producing S. sonnei (STSS) isolated in Europe. Here we report the first completely assembled whole genome sequence of a multidrug resistant (MDR) Stx-producing S...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28610604/age-and-environment-dependent-changes-in-chemical-defences-of-larval-and-post-metamorphic-toads
#18
Bálint Üveges, Gábor Fera, Ágnes M Móricz, Dániel Krüzselyi, Veronika Bókony, Attila Hettyey
BACKGROUND: Chemical defences are widespread in animals, but how their production is adjusted to ecological conditions is poorly known. Optimal defence theory predicts that inducible defences are favoured over constitutive defences when toxin production is costly and the need for it varies across environments. However, if some environmental changes occur predictably (e.g. coupled to transitions during ontogeny), whereas others are unpredictable (e.g. predation, food availability), changes in defences may have constitutive as well as plastic elements...
June 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28587671/integrative-taxonomy-by-molecular-species-delimitation-multi-locus-data-corroborate-a-new-species-of-balkan-drusinae-micro-endemics
#19
Simon Vitecek, Mladen Kučinić, Ana Previšić, Ivana Živić, Katarina Stojanović, Lujza Keresztes, Miklós Bálint, Felicitas Hoppeler, Johann Waringer, Wolfram Graf, Steffen U Pauls
BACKGROUND: Taxonomy offers precise species identification and delimitation and thus provides basic information for biological research, e.g. through assessment of species richness. The importance of molecular taxonomy, i.e., the identification and delimitation of taxa based on molecular markers, has increased in the past decade. Recently developed exploratory tools now allow estimating species-level diversity in multi-locus molecular datasets. RESULTS: Here we use molecular species delimitation tools that either quantify differences in intra- and interspecific variability of loci, or divergence times within and between species, or perform coalescent species tree inference to estimate species-level entities in molecular genetic datasets...
June 6, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28582455/correction-myosin-phosphatase-and-rhoa-activated-kinase-modulate-neurotransmitter-release-by-regulating-snap-25-of-snare-complex
#20
Dániel Horváth, István Tamás, Adrienn Sipos, Zsuzsanna Darula, Bálint Bécsi, Dénes Nagy, Judit Iván, Ferenc Erdődi, Beáta Lontay
[This corrects the article DOI: 10.1371/journal.pone.0177046.].
2017: PloS One
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