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András Kotschy, Zoltán Szlavik, James Murray, James Davidson, Ana Leticia Maragno, Gaëtane Le Toumelin-Braizat, Maïa Chanrion, Gemma L Kelly, Jia-Nan Gong, Donia M Moujalled, Alain Bruno, Márton Csekei, Attila Paczal, Zoltán B Szabo, Szabolcs Sipos, Gábor Radics, Agnes Proszenyak, Balázs Balint, Levente Ondi, Gábor Blasko, Alan Robertson, Allan Surgenor, Pawel Dokurno, Ijen Chen, Natalia Matassova, Julia Smith, Christopher Pedder, Christopher Graham, Aurélie Studeny, Gaëlle Lysiak-Auvity, Anne-Marie Girard, Fabienne Gravé, David Segal, Chris D Riffkin, Giovanna Pomilio, Laura C A Galbraith, Brandon J Aubrey, Margs S Brennan, Marco J Herold, Catherine Chang, Ghislaine Guasconi, Nicolas Cauquil, Fabien Melchiore, Nolwen Guigal-Stephan, Brian Lockhart, Frédéric Colland, John A Hickman, Andrew W Roberts, David C S Huang, Andrew H Wei, Andreas Strasser, Guillaume Lessene, Olivier Geneste
Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukemia 1 (MCL1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing has been challenging. Here we describe S63845, a small molecule that specifically binds with high affinity to the BH3-binding groove of MCL1. Our mechanistic studies demonstrate that S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway...
October 19, 2016: Nature
A Farsang, R Lévai, T Barna, K Fábián, S Blome, K Belák, Á Bálint, F Koenen, G Kulcsár
Maternally Derived Antibodies (MDA) can have a negative effect on the efficacy of live attenuated vaccines against classical swine fever (CSF). For this reason, a marker vaccine candidate CP7_E2alf was tested for its efficacy in the presence of MDA. Pregnant sows were vaccinated four weeks before farrowing with CSF virus (CSFV) strain "Thiverval". A total of 40 piglets with MDAs were included in this study. At six weeks of age the piglets were allocated into three treatment groups using generalized randomized block design (GRBD) blocking on serological status and pen location...
October 15, 2016: Biologicals: Journal of the International Association of Biological Standardization
Johannes Roth, Viviana Ravagnani, Marina Backhaus, Peter Balint, Alessandra Bruns, George A Bruyn, Paz Collado, Lorenia De la Cruz, Severine Guillaume-Czitrom, Troels Herlin, Cristina Hernandez, Annamaria Iagnocco, Sandrine Jousse-Joulin, Stefano Lanni, Vibke Lilleby, Clara Malattia, Silvia Magni-Manzoni, Consuelo Modesto, Ana Narrodi, Juan-Carlos Nieto, Sarah Ohrndorf, Linda Rossi, Anne-Marit Selvaag, Nanno Swen, Tracy Ting, Nikolay Tzaribachev, Patricia Vega-Fernandez, Jelena Vojinovic, Daniel Windschall, Maria-Antonietta D'Agostino, Esperanza Naredo
Objectives Musculoskeletal ultrasonography (US) has the potential to be an important tool in the assessment of disease activity in childhood arthritides. To assess pathology, clear definitions for synovitis need to be developed first. The aim of this study was to develop and validate these definitions through an international consensus process. Methods The decision on which US techniques to use, the components to be included in the definitions as well as the final wording were developed by 31 ultrasound experts in a consensus process...
October 16, 2016: Arthritis Care & Research
Bettina Balint, Kailash P Bhatia
No abstract text is available yet for this article.
October 14, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
André M Huss, Steffen Halbgebauer, Patrick Öckl, Corinna Trebst, Annette Spreer, Nadja Borisow, Andrea Harrer, Isabel Brecht, Bettina Balint, Oliver Stich, Sabine Schlegel, Nele Retzlaff, Alexander Winkelmann, Romy Roesler, Florian Lauda, Özlem Yildiz, Elke Voß, Rainer Muche, Sebastian Rauer, Florian Then Bergh, Markus Otto, Friedemann Paul, Brigitte Wildemann, Jörg Kraus, Klemens Ruprecht, Martin Stangel, Mathias Buttmann, Uwe K Zettl, Hayrettin Tumani
The majority of patients presenting with a first clinical symptom suggestive of multiple sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to the 2010 revision of the McDonald diagnostic criteria for MS and are thus classified as clinically isolated syndrome (CIS). To re-evaluate the utility of cerebrospinal fluid (CSF) analysis in the context of the revised McDonald criteria from 2010, we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands (OCBs) in patients with CIS...
October 11, 2016: Journal of Neurology
Mathieu Marmier, Giacomo Cecot, Anna V Vologzhanina, José L Bila, Ivica Zivkovic, Henrik M Ronnow, Balint Nafradi, Euro Solari, Philip Pattison, Rosario Scopelliti, Kay Severin
Dinuclear clathrochelate complexes with two, three, four, or five cyano groups in the ligand periphery were prepared following two distinct synthetic strategies: (a) zinc(ii)- or cobalt(ii)-templated polycondensation reactions of CN-functionalized arylboronic acids and phenoldioximes, or (b) postsynthetic cross-coupling reactions of polybrominated zinc(ii) clathrochelates with 4-cyanophenylboronic acid. The new clathrochelate complexes were used as metalloligands for the construction of heterometallic Zn(2+)/Ag(+) and Co(2+)/Ag(+) coordination polymers (CPs), which were characterized by single crystal X-ray diffraction and FT-IR...
October 4, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Bădicu Georgian, Balint Lorand
OBJECTIVE: The objective of this article is to present a methodology based on a questionnaire focused on social health, our study aims at highlighting, in a declarative and comparative manner, the development of social relationships between individuals, more or less for both adults who perform leisure sports activities and for those who do not practice. METHODS: The study was conducted between October 2012, March 2013 on a sample of 500 adults, who responded to a survey questionnaire, of whom 318 individuals perform leisure sports activities and 182 do not perform this kind of activities...
2016: SpringerPlus
Biljana Mihaljevic, Jelena Jelicic, Bosko Andjelic, Darko Antic, Olivera Markovic, Ivan Petkovic, Maja Perunicic Jovanovic, Goran Trajkovic, Jelena Bila, Vladislava Djurasinovic, Aleksandra Sretenovic, Vojin Vukovic, Mihailo Smiljanic, Milena Todorovic Balint
The Follicular Lymphoma International Prognostic Index (FLIPI) is widely used in the identification of risk groups among follicular lymphoma (FL) patients. The aim of the present study was to evaluate the prognostic value of FLIPI combined with the Charlson comorbidity index (CCI) and histological grade of lymphoma. 224 newly diagnosed FL patients (median age 56 years) treated with immunochemotherapy were retrospectively analysed. Low FLIPI had 21.0 % of patients, intermediate 28.1 % and high 46.9 %. 50...
October 6, 2016: International Journal of Hematology
Krisztina Voronova, Chrissa M Mozaffari Easter, Krisztián G Torma, Andras Bodi, Patrick Hemberger, Bálint Sztáray
The fragmentation processes of internal energy selected acetic acid anhydride cations, Ac2O(+), were investigated by imaging photoelectron photoion coincidence (iPEPICO) spectroscopy. The first dissociation channel leads to the formation of CH3C(O)OCO(+) (m/z = 87) by a CH3-loss. The 0 K appearance energy (E0) was determined to be 10.289 ± 0.010 eV, in excellent agreement with the G4-calculated 10.28 eV transition state (TS) energy. Based on the thermochemical onset of CH3C(O)OCO(+), a reverse barrier of 40 kJ mol(-1) was found...
September 14, 2016: Physical Chemistry Chemical Physics: PCCP
Metta Dülk, Gyöngyi Kudlik, Anna Fekete, Dávid Ernszt, Krisztián Kvell, Judit E Pongrácz, Balázs L Merő, Bálint Szeder, László Radnai, Miklós Geiszt, Dalma E Csécsy, Tamás Kovács, Ferenc Uher, Árpád Lányi, Virag Vas, László Buday
The commitment steps of mesenchymal stromal cells (MSCs) to adipogenic and other lineages have been widely studied but not fully understood. Therefore, it is critical to understand which molecules contribute to the conversion of stem cells into differentiated cells. The scaffold protein Tks4 plays a role in podosome formation, EGFR signaling and ROS production. Dysfunction of Tks4 causes a hereditary disease called Frank-ter Haar syndrome with a variety of defects concerning certain mesenchymal tissues (bone, fat and cartilage) throughout embryogenic and postnatal development...
October 6, 2016: Scientific Reports
Sung Ho Jang, Chul Hoon Chang, Young Jin Jung, Jeong Pyo Seo
No abstract text is available yet for this article.
October 4, 2016: Neurology
Ricardo H M Godoi, Sérgio J Gonçalves, Célia Sayama, Gabriela Polezer, José M Reis Neto, Bálint Alföldy, René Van Grieken, Carlos A Riedi, Carlos I Yamamoto, Ana F L Godoi, László Bencs
Serpentine and amphibole asbestos occur naturally in certain geologic settings worldwide, most commonly in association with ultramafic rocks, along associated faults. Ultramafic rocks have been used in Piên County, Southern Brazil for decades for the purpose of road paving in rural and urban areas, but without the awareness of their adverse environmental and health impact. The aim of this study was the chemical characterization of aerosols re-suspended in two rural roads of Piên, paved with ultramafic rocks and to estimate the pulmonary deposition of asbestos aerosols...
September 28, 2016: Environmental Science and Pollution Research International
Roland Darr, Joan Nambuba, Jaydira Del Rivero, Ingo Janssen, Maria Merino, Milena Todorovic, Bela Balint, Ivana Jochmanova, Josef T Prchal, Ronald Lechan, Arthur S Tischler, Vera Popovic, Dragana Miljic, Karen T Adams, F Ryan Prall, Alexander Ling, Meredith R Golomb, Michael Ferguson, Naris Nilubol, Clara Chen, Emily Chew, David Taieb, Constantine A Stratakis, Antonio Fojo, Chunzhang Yang, Electron Kebebew, Zhengping Zhuang, Karel Pacak
The syndrome of paraganglioma (PGL), somatostatinoma (SOM), and early childhood polycythemia in patients with somatic mutations in the hypoxia-inducible factor 2 alpha (HIF2A) gene is described in only a few patients worldwide. The present study provides detailed information about the clinical aspects and course of 7 patients with this syndrome and brings these experiences into perspective with the pertinent literature. Six females and one male presented at a median age of 28 years (range 11-46). Two were found to have HIF2A somatic mosaicism...
September 27, 2016: Endocrine-related Cancer
Imre Farkas, Csaba Vastagh, Erzsébet Farkas, Flóra Bálint, Katalin Skrapits, Erik Hrabovszky, Csaba Fekete, Zsolt Liposits
Glucagon-like peptide-1 (GLP-1), a metabolic signal molecule, regulates reproduction, although, the involved molecular mechanisms have not been elucidated, yet. Therefore, responsiveness of gonadotropin-releasing hormone (GnRH) neurons to the GLP-1 analog Exendin-4 and elucidation of molecular pathways acting downstream to the GLP-1 receptor (GLP-1R) have been challenged. Loose patch-clamp recordings revealed that Exendin-4 (100 nM-5 μM) elevated firing rate in hypothalamic GnRH-GFP neurons of male mice via activation of GLP-1R...
2016: Frontiers in Cellular Neuroscience
Bode Olukolu, Yang Bian, Brian De Vries, William F Tracy, Randall J Wisser, James Holland, Peter Balint-Kurti
Physiological leaf spotting, or flecking, is a mild lesion phenotype observed on the leaves of several commonly used maize inbred lines and has been anecdotally linked to enhanced broad-spectrum disease resistance. Flecking was assessed in the maize nested association mapping (NAM) population, comprising 4998 recombinant inbred lines from 25 bi-parental families, and in an association population comprised of 279 diverse maize inbreds. Joint family linkage analysis was conducted with 7386 markers in the NAM population...
September 26, 2016: Plant Physiology
Andrea Hettmann, Gabriella Juhász, Ágnes Dencs, Bálint Tresó, Erzsébet Rusvai, Éva Barabás, Mária Takács
A transfusion-associated hepatitis A outbreak was found in the first time in Hungary. The outbreak involved five cases. Parenteral transmission of hepatitis A is rare, but may occur during viraemia. Direct sequencing of nested PCR products was performed, and all the examined samples were identical in the VP1/2A region of the hepatitis A virus genome. HAV sequences found in recent years were compared and phylogenetic analysis showed that the strain which caused these cases is the same as that had spread in Hungary recently causing several hepatitis A outbreaks throughout the country...
September 23, 2016: Virus Genes
Csilla Celeng, Márton Kolossváry, Attila Kovács, Andrea Ágnes Molnár, Bálint Szilveszter, Tamás Horváth, Mihály Károlyi, Ádám L Jermendy, Ádám D Tárnoki, Dávid L Tárnoki, Júlia Karády, Szilard Voros, György Jermendy, Béla Merkely, Pál Maurovich-Horvat
OBJECTIVES: Previous studies using transthoracic echocardiography (TTE) observed moderate heritability of aortic root dimensions. Computed tomography angiography (CTA) might provide more accurate heritability estimates. Our primary aim was to assess the heritability of the aortic root with CTA. Our secondary aim was to derive TTE-based heritability and compare this with the CTA-based results. METHODS: In the BUDAPEST-GLOBAL study 198 twin subjects (118 monozygotic, 80 dizygotic; age 56...
September 22, 2016: European Radiology
Renáta Bor, Klaudia Farkas, Anita Bálint, Mónika Szűcs, Szabolcs Ábrahám, Ágnes Milassin, Mariann Rutka, Ferenc Nagy, Péter Milassin, Zoltán Szepes, Tamás Molnár
OBJECTIVES: Magnetic resonance imaging (MRI) and transrectal sonography are the two accepted imaging modalities for evaluation of perianal fistulas and abscesses. Transperineal sonography is a new technique that is easy to learn and can be performed at any time. The purpose of this study was to prospectively compare the diagnostic accuracy of MRI, transrectal sonography, and transperineal sonography with surgical findings in patients with perianal Crohn disease. METHODS: All patients with perianal Crohn disease underwent MRI, transrectal sonography, and transperineal sonography within a few days before surgery...
September 14, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Bulcsú Sándor, Ingve Simonsen, Bálint Zsolt Nagy, Zoltán Néda
The gain-loss asymmetry, observed in the inverse statistics of stock indices is present for logarithmic return levels that are over 2%, and it is the result of the non-Pearson-type autocorrelations in the index. These non-Pearson-type correlations can be viewed also as functionally dependent daily volatilities, extending for a finite time interval. A generalized time-window shuffling method is used to show the existence of such autocorrelations. Their characteristic time scale proves to be smaller (less than 25 trading days) than what was previously believed...
August 2016: Physical Review. E
Éva Borbély, Zsófia Hajna, Liza Nabi, Bálint Scheich, Valéria Tékus, Kristóf László, Tamás Ollmann, Viktória Kormos, Balázs Gaszner, Zoltán Karádi, László Lénárd, Christopher J Paige, John P Quinn, János Szolcsányi, Erika Pintér, Julie Keeble, Alexandra Berger, Zsuzsanna Helyes
The tachykinin NK1 receptor was suggested to be involved in psychiatric disorders, but its antagonists have failed to be effective as antidepressants in clinical trials. Hemokinin-1 (HK-1), the newest tachykinin, is present in several brain regions and activates the NK1 receptor similarly to substance P (SP), but acts also through other mechanisms. Therefore, we investigated the roles of the Tac4 gene-derived HK-1 in comparison with SP and neurokinin A (NKA) encoded by the Tac1 gene, as well as the NK1 receptor in anxiety and depression-like behaviors in mice...
September 9, 2016: Brain, Behavior, and Immunity
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