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https://www.readbyqxmd.com/read/29167036/inverse-association-between-hyperthymic-affective-temperament-and-coronary-atherosclerosis-a-coronary-computed-tomography-angiography-study
#1
János Nemcsik, Milán Vecsey-Nagy, Bálint Szilveszter, Márton Kolossváry, Júlia Karády, Andrea László, Beáta Kőrösi, Zsófia Nemcsik-Bencze, Xénia Gonda, Béla Merkely, Zoltán Rihmer, Pál Maurovich-Horvat
OBJECTIVE: A bidirectional relationship exists between psychiatric disorders and cardiovascular diseases, however less is known with regards to personality traits. Accumulating data suggest that affective temperaments are both associated with psychiatric and somatic diseases. The aim of our study was to evaluate the associations between different affective temperaments and the presence of coronary atherosclerosis. METHODS: 200 consecutive patients referred to coronary computed tomography angiography (CCTA) due to suspected coronary artery disease (CAD) were included in our study...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29167035/promoting-empathy-among-medical-students-a-two-site-randomized-controlled-study
#2
Céline Buffel du Vaure, Cédric Lemogne, Lucie Bunge, Annie Catu-Pinault, Nicolas Hoertel, Christian Ghasarossian, Marie-Eve Vincens, Eric Galam, Philippe Jaury
OBJECTIVE: To assess the effects of Balint groups on empathy measured by the Consultation And Relational Empathy Measure (CARE) scale rated by standardized patients during objective structured clinical examination and self-rated Jefferson's School Empathy Scale - Medical Student (JSPE-MS©) among fourth-year medical students. METHODS: A two-site randomized controlled trial were planned, from October 2015 to December 2015 at Paris Diderot and Paris Descartes University, France...
December 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29158123/efficacy-and-safety-of-necitumumab-continuation-therapy-in-the-phase-iii-squire-study-of-patients-with-stage-iv-squamous-non-small-cell-lung-cancer
#3
Tudor Ciuleanu, Mark A Socinski, Coleman Obasaju, Alexander V Luft, Aleksandra Szczesna, Wojciech Szafrański, Rodryg Ramlau, Beatrix Bálint, Olivier Molinier, Henrik Depenbrock, Shivani Nanda, Luis Paz-Ares, Nick Thatcher
INTRODUCTION: In a retrospective analysis of the SQUamous NSCLC treatment with the Inhibitor of EGF REceptor (SQUIRE) study, we investigated the efficacy and safety of single-agent necitumumab continuation therapy in patients with stage IV squamous non-small-cell lung cancer and in a subpopulation of patients with epidermal growth factor receptor (EGFR)-expressing tumors. PATIENTS AND METHODS: Patients were randomized 1:1 for ≤ 6 cycles of gemcitabine and cisplatin either with or without necitumumab...
October 13, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29153681/various-levels-of-circulating-exosomal-total-mirna-and-mir-210-hypoxamir-in-different-forms-of-pregnancy-hypertension
#4
Orsolya Biró, Bálint Alasztics, Attila Molvarec, József Joó, Bálint Nagy, János Rigó
INTRODUCTION: Hypertension is a common complication during pregnancy, affecting 10% of pregnant women worldwide. Several microRNA (miRNA) were shown to be involved in hypertensive disorders of pregnancy. In preeclampsia (PE), placental dysfunction causes the enhanced release of extracellular vesicle-derived miRNAs. The hypoxia-sensitive hsa-mir-210 is the most common PE-associated miRNA, but its exosomal profile has not been investigated. OBJECTIVES: Our aims were to measure exosomal total-miRNA concentration and to perform expression analysis of circulating exosomal hsa-miR-210 in women affected by chronic hypertension (CHT) gestational hypertension (GHT) or PE...
October 2017: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29141778/pathophysiology-and-risk-of-atrial-fibrillation-detected-after-ischemic-stroke-paradise-a-translational-integrated-and-transdisciplinary-approach
#5
Maryse Paquet, Joshua O Cerasuolo, Victoria Thorburn, Sebastian Fridman, Rasha Alsubaie, Renato D Lopes, Lauren E Cipriano, Paula Salamone, C W James Melling, Ali R Khan, Lucas Sedeño, Jiming Fang, Maria Drangova, Manuel Montero-Odasso, Jennifer Mandzia, Alexander V Khaw, Juan M Racosta, Justin Paturel, Lucy Samoilov, Devin Stirling, Brittany Balint, Victoria Jaremek, Marlys L Koschinsky, Michael B Boffa, Kelly Summers, Agustín Ibañez, Marko Mrkobrada, Gustavo Saposnik, Kurt Kimpinski, Shawn N Whitehead, Luciano A Sposato
BACKGROUND: It has been hypothesized that ischemic stroke can cause atrial fibrillation. By elucidating the mechanisms of neurogenically mediated paroxysmal atrial fibrillation, novel therapeutic strategies could be developed to prevent atrial fibrillation occurrence and perpetuation after stroke. This could result in fewer recurrent strokes and deaths, a reduction or delay in dementia onset, and in the lessening of the functional, structural, and metabolic consequences of atrial fibrillation on the heart...
November 13, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29141015/nematocytes-discovery-and-characterization-of-a-novel-anculeate-hemocyte-in-drosophila-falleni-and-drosophila-phalerata
#6
Julianna Bozler, Balint Z Kacsoh, Giovanni Bosco
Immune challenges, such as parasitism, can be so pervasive and deleterious that they constitute an existential threat to a species' survival. In response to these ecological pressures, organisms have developed a wide array of novel behavioral, cellular, and molecular adaptations. Research into these immune defenses in model systems has resulted in a revolutionary understanding of evolution and functional biology. As the field has expanded beyond the limited number of model organisms our appreciation of evolutionary innovation and unique biology has widened as well...
2017: PloS One
https://www.readbyqxmd.com/read/29140762/the-genus-parasola-phylogeny-and-the-description-of-three-new-species
#7
János G Szarkándi, Geert Schmidt-Stohn, Bálint Dima, Shah Hussain, Sándor Kocsubé, Tamás Papp, Csaba Vágvölgyi, László G Nagy
Parasola represents an enigmatic lineage of veil-less, coprinoid fungi in Psathyrellaceae (Agaricales). The species-level taxonomy of the genus has been in a flux recently, resulting in the elimination of some long-established names and the description of new taxa. Here, we reconstruct the phylogeny of Parasola using two nuc rDNA loci, the internal transcribed spacer region (ITS1-5.8S-ITS2) and 28S and identify several putatively undescribed species, of which three are formally described here (Parasola crataegi, P...
October 9, 2017: Mycologia
https://www.readbyqxmd.com/read/29136219/mobidb-3-0-more-annotations-for-intrinsic-disorder-conformational-diversity-and-interactions-in-proteins
#8
Damiano Piovesan, Francesco Tabaro, Lisanna Paladin, Marco Necci, Ivan Micetic, Carlo Camilloni, Norman Davey, Zsuzsanna Dosztányi, Bálint Mészáros, Alexander M Monzon, Gustavo Parisi, Eva Schad, Pietro Sormanni, Peter Tompa, Michele Vendruscolo, Wim F Vranken, Silvio C E Tosatto
The MobiDB (URL: mobidb.bio.unipd.it) database of protein disorder and mobility annotations has been significantly updated and upgraded since its last major renewal in 2014. Several curated datasets for intrinsic disorder and folding upon binding have been integrated from specialized databases. The indirect evidence has also been expanded to better capture information available in the PDB, such as high temperature residues in X-ray structures and overall conformational diversity. Novel nuclear magnetic resonance chemical shift data provides an additional experimental information layer on conformational dynamics...
November 10, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29135442/-lottery-and-suicide-the-effect-of-number-of-lottery-tickets-on-hungarian-suicide-rates
#9
Péter Osváth, Lajos Bálint, Károly Bozsonyi
AIM: The relationship of suicide and gambling is a neglected field in the study of suicidology. In Hungary, no statistical studies have been published to date with regard to the whole of the population. Our study investigates the relationship between a very popular high prize game, lottery, and suicide rates. METHOD: The relationship between daily rates of suicide by gender and age and the number of winning tickets has been analysed over the periods between 1991 and 1997 and from 1997 to 2013...
2017: Psychiatria Hungarica: A Magyar Pszichiátriai Társaság Tudományos Folyóirata
https://www.readbyqxmd.com/read/29134099/assessment-of-owner-directed-aggressive-behavioural-tendencies-of-dogs-in-situations-of-possession-and-manipulation
#10
Anna Bálint, Gabriella Rieger, Ádám Miklósi, Péter Pongrácz
Excessive aggression is a common behaviour problem in dogs that can have various destructive effects on the affected people and the implicated dog. Aggressive behaviour directed towards the owner or other family members is one of the most frequently occurring aggressive phenotypes. Here, we examine the reliability of a short questionnaire assessing aggressive behaviours by two, contextually different behavioural tests: 'take away bone' and 'roll over'. Based on dogs' behaviour in the tests, we sorted dogs (N = 93) in two groups for each test, namely a less and a more disobedient/resistant group...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29130793/from-genomes-to-diaries-a-3-year-prospective-real-life-study-of-ragweed-specific-sublingual-immunotherapy
#11
Viktor Molnár, Adrienne Nagy, Lilla Tamási, Gabriella Gálffy, Renáta Böcskei, András Bikov, Ibolya Czaller, Zsuzsanna Csoma, Magdolna Krasznai, Csilla Csáki, Györgyi Zsigmond, Zoltán Csontos, Anikó Kurucz, Edina Kurucz, Beáta Fábos, Bálint L Bálint, Mária Sasvári-Székely, Anna Székely, Eszter Kótyuk, Gergely T Kozma, Gábor Cserta, Anita Farkas, Zsófia Gál, András Gézsi, András Millinghoffer, Péter Antal, Csaba Szalai
During the last decades, the prevalence of allergy has dramatically increased. Allergen-specific immunotherapy is the only currently available medical intervention that has the potential to affect the natural course of the disease, but there are still many questions and unmet needs hindering its widespread use to fulfill its treatment potential and maximize its benefits for the society. To provide a comprehensive phenome-wide overview in sublingual immunotherapy, using ragweed allergy as a target, we planned and carried out a longitudinal, prospective, observational, open-label study (DesensIT)...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29130134/is-it-possible-to-improve-prognostic-value-of-nccn-ipi-in-patients-with-diffuse-large-b-cell-lymphoma-the-prognostic-significance-of-comorbidities
#12
Darko Antic, Jelena Jelicic, Goran Trajkovic, Milena Todorovic Balint, Jelena Bila, Olivera Markovic, Ivan Petkovic, Vesna Nikolic, Bosko Andjelic, Vladislava Djurasinovic, Aleksandra Sretenovic, Mihailo Smiljanic, Vojin Vukovic, Biljana Mihaljevic
The prognostic value of the International Prognostic Index (IPI) has been re-evaluated in the rituximab-treated diffuse large B cell lymphoma (DLBCL) patients. Accordingly, National Comprehensive Cancer Network-IPI (NCCN-IPI) has been introduced to estimate prognosis of DLBCL patients. However, comorbidities that frequently affect elderly DLBCL patients were not analyzed. The aim of this study was to evaluate the prognostic significance of comorbidities using Charlson Comorbidity Index (CCI) in 962 DLBCL patients...
November 12, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/29122317/sonographic-and-anatomic-description-of-the-subtalar-joint
#13
Peter Mandl, David Bong, Peter V Balint, Hilde Berner Hammer, Maribel Miguel, Esperanza Naredo, Lene Terslev, Ingrid Möller
Our study provides a detailed anatomic and sonographic description of the subtalar joint, a single joint that, anatomically, is divided into the anterior subtalar joint (ASTJ) and the posterior subtalar joint (PSTJ). Cadaver specimens of the ankle and foot were examined in detail by ultrasound (US), and the subtalar joints of all the specimens were injected with colored latex of a contrasting color under US guidance. Compatible with other studies, examination of the sections revealed lack of communication between the ASTJ and the PSTJ and communication between the PSTJ and the posterior recess of the tibiotalar joint...
November 6, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29116390/cad-rads-a-new-clinical-decision-support-tool-for-coronary-computed-tomography-angiography
#14
Borek Foldyna, Bálint Szilveszter, Jan-Erik Scholtz, Dahlia Banerji, Pál Maurovich-Horvat, Udo Hoffmann
Coronary computed tomography angiography (CTA) has been established as an accurate method to non-invasively assess coronary artery disease (CAD). The proposed 'Coronary Artery Disease Reporting and Data System' (CAD-RADS) may enable standardised reporting of the broad spectrum of coronary CTA findings related to the presence, extent and composition of coronary atherosclerosis. The CAD-RADS classification is a comprehensive tool for summarising findings on a per-patient-basis dependent on the highest-grade coronary artery lesion, ranging from CAD-RADS 0 (absence of CAD) to CAD-RADS 5 (total occlusion of a coronary artery)...
November 7, 2017: European Radiology
https://www.readbyqxmd.com/read/29115336/optical-detection-of-charge-dynamics-in-ch3nh3pbi3-carbon-nanotube-composites
#15
Hajnalka M Tóháti, Áron Pekker, Pavao Andričević, László Forró, Bálint Náfrádi, Márton Kollár, Endre Horváth, Katalin Kamarás
We have investigated the optical absorption of metallic and semiconducting carbon nanotubes/CH3NH3PbI3 micro- and nanowire composites. Upon visible light illumination semiconducting carbon nanotube based samples show a photo-induced doping, originating from the charge carriers created in the perovskite while this kind of change is absent in the composites containing metallic nanotubes, due to their strikingly different electronic structure. The response in the nanotubes shows, beside a fast diffusion of photo-generated charges, a slow component similar to that observed in pristine CH3NH3PbI3 attributed to structural rearrangement, and leading to slight, light induced changes of the optical gap of the perovskite...
November 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/29109524/navigating-complexity-to-breed-disease-resistant-crops
#16
REVIEW
Rebecca Nelson, Tyr Wiesner-Hanks, Randall Wisser, Peter Balint-Kurti
Plant diseases are responsible for substantial crop losses each year and pose a threat to global food security and agricultural sustainability. Improving crop resistance to pathogens through breeding is an environmentally sound method for managing disease and minimizing these losses. However, it is challenging to breed varieties with resistance that is effective, stable and broad-spectrum. Recent advances in genetic and genomic technologies have contributed to a better understanding of the complexity of host-pathogen interactions and have identified some of the genes and mechanisms that underlie resistance...
November 7, 2017: Nature Reviews. Genetics
https://www.readbyqxmd.com/read/29103607/experience-with-an-on-site-coronary-computed-tomography-derived-fractional-flow-reserve-algorithm-for-the-assessment-of-intermediate-coronary-stenoses
#17
Patrick M Donnelly, Márton Kolossváry, Júlia Karády, Peter A Ball, Stephanie Kelly, Donna Fitzsimons, Mark S Spence, Csilla Celeng, Tamás Horváth, Bálint Szilveszter, Hendrik W van Es, Martin J Swaans, Béla Merkely, Pál Maurovich-Horvat
Fractional flow reserve (FFR) derived from coronary computed tomography angiography (CTA) is a new technique for the diagnosis of ischemic coronary artery stenoses. The aim of this prospective study was to evaluate the diagnostic performance of a novel on-site computed tomography-based fractional flow reserve algorithm (CT-FFR) compared with invasive FFR as the gold standard, and to determine whether its diagnostic performance is affected by interobserver variations in lumen segmentation. We enrolled 44 consecutive patients (64...
October 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29093525/dynamic-changes-in-binding-interaction-networks-of-sex-steroids-establish-their-non-classical-effects
#18
Mónika Bálint, Norbert Jeszenői, István Horváth, István M Ábrahám, Csaba Hetényi
Non-classical signaling in the intracellular second messenger system plays a pivotal role in the cytoprotective effect of estradiol. Estrogen receptor is a common target of sex steroids and important in mediating estradiol-induced neuroprotection. Whereas the mechanism of genomic effects of sex steroids is fairly understood, their non-classical effects have not been elucidated completely. We use real time molecular dynamics calculations to uncover the interaction network of estradiol and activator estren. Besides steroid interactions, we also investigate the co-activation of the receptor...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29093149/developing-prosthodontic-residents-communication-strategies-with-edentulous-patients-a-pilot-study
#19
Varsha Murthy, K R Sethuraman, Sunayana Choudhury, P Shakila
The aim of this study was to investigate whether prosthodontic residents' attitudes toward provider-client communication would be shaped by a tailor-made communications skills course. In 2016, the pre-intervention attitudes of all six second- and third-year prosthodontic residents in a three-year residency at an academic dental institution in India were assessed using the Communication Skills Attitude Scale (CSAS). The residents' performance was then video-recorded while they treated complete denture patients and was analyzed using the Kalamazoo scale, a validated scale for communication skills assessment...
November 2017: Journal of Dental Education
https://www.readbyqxmd.com/read/29091000/image-quality-of-prospectively-ecg-triggered-coronary-ct-angiography-in-heart-transplant-recipients
#20
Andrea Bartykowszki, Márton Kolossváry, Ádám Levente Jermendy, Júlia Karády, Bálint Szilveszter, Mihály Károlyi, Orsolya Balogh, Balázs Sax, Béla Merkely, Pál Maurovich-Horvat
OBJECTIVE: Cardiac allograft vasculopathy (CAV) is among the top causes of death 1 year after heart transplantation (HTx). Coronary CT angiography (CTA) is a potential alternative to invasive imaging in the diagnosis of CAV. However, the higher heart rate (HR) of HTx recipients prompts the use of retrospective ECG-gating, which is associated with higher radiation dose, a major concern in this patient population. Therefore, we sought to evaluate the feasibility and image quality of low-radiation-dose prospectively ECG-triggered coronary CTA in HTx recipients...
November 1, 2017: AJR. American Journal of Roentgenology
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