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https://www.readbyqxmd.com/read/29773820/genetic-diversity-of-prrsv-1-in-central-eastern-europe-in-1994-2014-origin-and-evolution-of-the-virus-in-the-region
#1
Gyula Balka, Katarzyna Podgórska, Manreetpal Singh Brar, Ádám Bálint, Daniel Cadar, Vladimir Celer, Lilla Dénes, Zuzana Dirbakova, Anna Jedryczko, Lázár Márton, Dinko Novosel, Tamaš Petrović, Ivo Sirakov, Dóra Szalay, Ivan Toplak, Frederick Chi-Ching Leung, Tomasz Stadejek
More than 20 years after the first outbreaks, the phylogenetic picture of PRRSV is still incomplete and full of gaps, especially in regards of PRRSV 1. Due to the exceptional diversity observed at the eastern borders of Europe and the low number of available sequences from Central Eastern European countries, the authors collected and analyzed both recent as well as already submitted sequences comparing them to a large backbone set of available ORF5 sequences representing the full spectrum of PRRSV 1 Subtype 1 diversity to conduct a systematic phylogenetic analysis and reclassification elucidating the diversity of the virus in these countries...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29760725/the-effects-of-hyperacute-serum-on-the-elements-of-the-human-subchondral-bone-marrow-niche
#2
Melinda Simon, Bálint Major, Gabriella Vácz, Olga Kuten, István Hornyák, Adél Hinsenkamp, Dorottya Kardos, Marcell Bagó, Domonkos Cseh, Adrienn Sárközi, Denes Horvathy, Stefan Nehrer, Zsombor Lacza
Mesenchymal stem cells (MSCs) are widely used in laboratory experiments as well as in human cell therapy. Their culture requires animal sera like fetal calf serum (FCS) as essential supplementation; however, animal sera pose a risk for clinical applications. Human blood derivatives, for example, platelet-rich plasma (PRP) releasates, are potential replacements of FCS; however, it is unclear which serum variant has the best effect on the given cell or tissue type. Additionally, blood derivatives are commonly used in musculoskeletal diseases like osteoarthritis (OA) or osteonecrosis as "proliferative agents" for the topical MSC pool...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29755360/healthy-lung-vessel-morphology-derived-from-thoracic-computed-tomography
#3
Michael Pienn, Caroline Burgard, Christian Payer, Alexander Avian, Martin Urschler, Rudolf Stollberger, Andrea Olschewski, Horst Olschewski, Thorsten Johnson, Felix G Meinel, Zoltán Bálint
Knowledge of the lung vessel morphology in healthy subjects is necessary to improve our understanding about the functional network of the lung and to recognize pathologic deviations beyond the normal inter-subject variation. Established values of normal lung morphology have been derived from necropsy material of only very few subjects. In order to determine morphologic readouts from a large number of healthy subjects, computed tomography pulmonary angiography (CTPA) datasets, negative for pulmonary embolism, and other thoracic pathologies, were analyzed using a fully-automatic, in-house developed artery/vein separation algorithm...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29754509/-new-and-traditional-directions-in-the-biology-and-management-of-childhood-acute-lymphoblastic-leukemia
#4
Bálint Egyed, Gábor Kovács, Nóra Kutszegi, Andrea Rzepiel, Judit Csányiné Sági, Dániel János Erdélyi, Judit Müller, Ágnes Félné Semsei
Owing to clinical trials and improvement over the past few decades, the majority of children with acute lymphoblastic leukemia (ALL) survive by first-line chemotherapy and combat with the problems of returning to community. However, many patients may have severe acute or late therapeutic side effects, and the survival rate in some groups (e.g., patients with MLL rearrangements, hypodiploidy, IKZF1 mutation or early precursor T cell phenotype) is far behind the average. Innovative strategies in medical attendance provide better clinical outcomes for them: complete gene diagnostics, molecularly targeted anticancer treatment, immuno-oncology and immune cell therapy...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29741807/genetically-determined-pattern-of-left-ventricular-function-in-normal-and-hypertensive-hearts
#5
Attila Kovács, Andrea Ágnes Molnár, Márton Kolossváry, Bálint Szilveszter, Alexisz Panajotu, Bálint Károly Lakatos, Levente Littvay, Ádám Domonkos Tárnoki, Dávid László Tárnoki, Szilard Voros, György Jermendy, Partho P Sengupta, Béla Merkely, Pál Maurovich-Horvat
We sought to assess the inheritance of left ventricular (LV) function using speckle-tracking echocardiography and the impact of hypertension on modifying the genetically determined pattern of contraction in a population of twins. We recruited 92 Caucasian twin pairs, including 74 hypertensive (HTN) siblings. Beyond standard echocardiographic protocol, a speckle-tracking analysis was performed, including global longitudinal strain (GLS). Systolic function, as assessed by ejection fraction, showed moderate heritability (61%); however, GLS showed higher and dominant heritability (75%)...
May 9, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29739525/the-overall-diagnosis-psychodynamic-psychiatry-six-minute-psychotherapy-and-patient-centered-care
#6
REVIEW
Elizabeth Weinberg, David Mintz
Optimal patient care in psychiatry necessitates attention to the treatment relationship and to the patient's experience as an individual. The growth of patient-centered medicine has led to an increased appreciation of the importance of the biopsychosocial formulation, the personhood of both the patient and the physician, the autonomy and authority of the patient, and the therapeutic alliance. Patient-centered medicine, developed by the seminal psychoanalytic theorist Michael Balint, has its roots in psychodynamic concepts...
June 2018: Psychiatric Clinics of North America
https://www.readbyqxmd.com/read/29735672/strategic-investment-explains-patterns-of-cooperation-and-cheating-in-a-microbe
#7
Philip G Madgwick, Balint Stewart, Laurence J Belcher, Christopher R L Thompson, Jason B Wolf
Contributing to cooperation is typically costly, while its rewards are often available to all members of a social group. So why should individuals be willing to pay these costs, especially if they could cheat by exploiting the investments of others? Kin selection theory broadly predicts that individuals should invest more into cooperation if their relatedness to group members is high (assuming they can discriminate kin from nonkin). To better understand how relatedness affects cooperation, we derived the ‟Collective Investment" game, which provides quantitative predictions for patterns of strategic investment depending on the level of relatedness...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29735015/the-causal-role-of-the-somatosensory-cortex-in-prosocial-behaviour
#8
Selene Gallo, Riccardo Paracampo, Laura Müller-Pinzler, Mario Carlo Severo, Laila Blömer, Carolina Fernandes-Henriques, Anna Henschel, Balint Kalista Lammes, Tatjana Maskaljunas, Judith Suttrup, Alessio Avenanti, Christian Keysers, Valeria Gazzola
Witnessing another person's suffering elicits vicarious brain activity in areas active when we ourselves are in pain. Whether this activity influences prosocial behavior remains debated. Here participants witnessed a confederate express pain via a reaction of the swatted hand or via a facial expression and could decide to reduce that pain by donating money. Participants donate more money on trials in which the confederate expressed more pain. EEG shows that activity of the SI hand region explains variance in donation; TMS shows that altering this activity interferes with the pain-donation coupling only when pain is expressed by the hand and HD-tDCS that altering SI activity also interferes with pain perception...
May 8, 2018: ELife
https://www.readbyqxmd.com/read/29733592/efficient-automatized-density-functional-tight-binding-parameterizations-application-to-group-iv-elements
#9
Ahmad W Huran, Conrad Steigemann, Thomas Frauenheim, Bálint Aradi, Miguel A L Marques
Density-functional tight-binding methods stand out as a very good compromise between accuracy and computational efficiency. These methods rely on parameter sets that have to be determined and tabulated for every pair of chemical elements. We describe an efficient, and to a large extent automatic, procedure to build such parameter sets. This procedure includes the generation of unbiased training sets, and subsequent optimization of the parameters using a pattern search method. As target for the optimization we ask that the formation energy and the forces on the atoms calculated within tight-binding reproduce the ones obtained using density-functional theory...
May 7, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29732447/high-resolution-adhesion-kinetics-of-egcg-exposed-tumor-cells-on-biomimetic-interfaces-comparative-monitoring-of-cell-viability-using-label-free-biosensor-and-classic-end-point-assays
#10
Beatrix Peter, Rita Ungai-Salanki, Bálint Szabó, Agoston G Nagy, Inna Szekacs, Szilvia Bősze, Robert Horvath
A high-throughput label-free resonant waveguide grating biosensor, the Epic BenchTop, was utilized to in situ monitor the adhesion process of cancer cells on Arg-Gly-Asp tripeptide displaying biomimetic polymer surfaces. Using highly adherent human cervical adenocarcinoma (HeLa) cells as a model system, cell adhesion kinetic data with outstanding temporal resolution were obtained. We found that pre-exposing the cells to various concentrations of the main extract of green tea, the (-)-epigallocatechin gallate (EGCG), largely affected the temporal evolution of the adhesion process...
April 30, 2018: ACS Omega
https://www.readbyqxmd.com/read/29731709/spike-timing-of-orbitofrontal-neurons-is-synchronized-with-breathing
#11
Áron Kőszeghy, Bálint Lasztóczi, Thomas Forro, Thomas Klausberger
The orbitofrontal cortex (OFC) has been implicated in a multiplicity of complex brain functions, including representations of expected outcome properties, post-decision confidence, momentary food-reward values, complex flavors and odors. As breathing rhythm has an influence on odor processing at primary olfactory areas, we tested the hypothesis that it may also influence neuronal activity in the OFC, a prefrontal area involved also in higher order processing of odors. We recorded spike timing of orbitofrontal neurons as well as local field potentials (LFPs) in awake, head-fixed mice, together with the breathing rhythm...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29729648/analysis-of-the-influence-of-simulation-parameters-on-biomolecule-linked-water-networks
#12
Norbert Jeszenői, Gabriella Schilli, Mónika Bálint, István Horváth, Csaba Hetényi
Advancement of computational molecular dynamics allows rapid calculation of large biomolecular systems in their water surroundings. New approaches of prediction of hydration networks of biomolecular surfaces and complex interfaces are also based on molecular dynamics (MD). Calculations with explicit solvent models can trace thousands of water molecules individually on a real time scale, yielding information on their mobility, and predicting their networking with biomolecular solutes and other water partners...
April 27, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29726066/partial-loss-of-function-of-sodium-channel-scn8a-in-familial-isolated-myoclonus
#13
Jacy L Wagnon, Niccolò E Mencacci, Bryan S Barker, Eric R Wenger, Kailash P Bhatia, Bettina Balint, Miryam Carecchio, Nicholas W Wood, Manoj K Patel, Miriam H Meisler
Variants in the neuronal sodium channel gene SCN8A have been implicated in several neurological disorders. Early infantile epileptic encephalopathy type 13 results from de novo gain-of-function mutations that alter the biophysical properties of the channel. Complete loss-of-function variants of SCN8A have been identified in cases of isolated intellectual disability. We now report a novel heterozygous SCN8A variant, p.Pro1719Arg in a small pedigree with five family members affected with autosomal dominant upper limb isolated myoclonus without seizures or cognitive impairment...
May 3, 2018: Human Mutation
https://www.readbyqxmd.com/read/29720808/chronic-lymphocytic-leukemia-involvement-of-central-nervous-system-clinical-diversity-diagnostic-algorithm-and-therapeutic-challenges
#14
Biljana Mihaljevic, Mihailo Smiljanic, Darko Antic, Nada Kraguljac Kurtovic, Milena Todorovic Balint
No abstract text is available yet for this article.
January 2018: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/29719573/synthesis-and-in-vitro-biochemical-evaluation-of-oxime-bond-linked-daunorubicin-gnrh-iii-conjugates-developed-for-targeted-drug-delivery
#15
Sabine Schuster, Beáta Biri-Kovács, Bálint Szeder, Viktor Farkas, László Buday, Zsuzsanna Szabó, Gábor Halmos, Gábor Mező
Gonadotropin releasing hormone-III (GnRH-III), a native isoform of the human GnRH isolated from sea lamprey, specifically binds to GnRH receptors on cancer cells enabling its application as targeting moieties for anticancer drugs. Recently, we reported on the identification of a novel daunorubicin-GnRH-III conjugate (GnRH-III-[4 Lys(Bu), 8 Lys(Dau=Aoa)] with efficient in vitro and in vivo antitumor activity. To get a deeper insight into the mechanism of action of our lead compound, the cellular uptake was followed by confocal laser scanning microscopy...
2018: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29715025/synergistic-effects-of-nitrogen-and-potassium-on-quantitative-limitations-to-photosynthesis-in-rice-oryza-sativa-l
#16
Wenfeng Hou, Jinyao Yan, Bálint Jákli, Jianwei Lu, Tao Ren, Rihuan Cong, Xiaokun Li
Inhibition of net CO2 assimilation (A) during photosynthesis is one of the major physiological effects of both nitrogen (N) and potassium (K) deficiency on the growth of rice. Whether the reduction of A arises from the limitation either to the diffusion and biochemical fixation of CO2 or to the photochemical energy conversion is still debated for the deficiency of N and K. In this study, gas exchange parameters of rice under different N and K levels were evaluated and the limitations to the capture process of photosynthetic carbon were quantified...
May 1, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29710633/endocrine-disruptors-in-breeding-ponds-and-reproductive-health-of-toads-in-agricultural-urban-and-natural-landscapes
#17
Veronika Bókony, Bálint Üveges, Nikolett Ujhegyi, Viktória Verebélyi, Edina Nemesházi, Olivér Csíkvári, Attila Hettyey
Many chemical pollutants have endocrine disrupting effects which can cause lifelong reproductive abnormalities in animals. Amphibians are the most threatened group of vertebrates, but there is little information on the nature and quantity of pollutants occurring in typical amphibian breeding habitats and on the reproductive capacities of amphibian populations inhabiting polluted areas. In this study we investigated the occurrence and concentrations of endocrine disrupting chemicals in the water and sediment of under-studied amphibian breeding habitats in natural, agricultural and urbanized landscapes...
April 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29710546/pharmacokinetic-interaction-of-diosmetin-and-silibinin-with-other-drugs-inhibition-of-cyp2c9-mediated-biotransformation-and-displacement-from-serum-albumin
#18
Miklós Poór, Gabriella Boda, Violetta Mohos, Mónika Kuzma, Mónika Bálint, Csaba Hetényi, Tímea Bencsik
Diosmin and silibinin (SIL) are polyphenolic compounds which are the active components of several drugs and dietary supplements. After the oral administration of diosmin (flavonoid glycoside), only its aglycone diosmetin (DIO) reaches the systemic circulation. Both DIO and SIL form complexes with serum albumin and are able to inhibit several cytochrome P450 enzymes. Therefore, it is reasonable to hypothesize that these polyphenols may displace some drugs from serum albumin and inhibit their biotransformation, potentially leading to the disruption of drug therapy...
March 31, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29709692/turning-one-into-five-integrative-taxonomy-uncovers-complex-evolution-of-cryptic-species-in-the-harvester-ant-messor-structor
#19
Florian M Steiner, Sándor Csősz, Bálint Markó, Alexander Gamisch, Lukas Rinnhofer, Clemens Folterbauer, Sarina Hammerle, Christian Stauffer, Wolfgang Arthofer, Birgit C Schlick-Steiner
Seed harvesting ants are ecosystem engineers that shape vegetation, nutrient cycles, and microclimate. Progress in ecological research is, however, slowed down by poor species delimitation. For example, it has not been resolved to date, how many species the European harvester ant Messor "structor" (Latreille, 1798) represents. Since its first description, splitting into additional taxa was often proposed but not accepted later on due to inconsistent support from morphology and ecology. Here, we took an iterative integrative-taxonomy approach - comparing multiple, independent data sets of the same sample - and used traditional morphometrics, Wolbachia symbionts, mitochondrial DNA, amplified fragment length polymorphism, and ecological niche modelling...
April 27, 2018: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29702452/decision-making-performance-of-depressed-patients-within-72-h-following-a-suicide-attempt
#20
Klára M Hegedűs, Andrea Szkaliczki, Bernadett I Gál, Bálint Andó, Zoltán Janka, Péter Z Álmos
BACKGROUND: The significance of decision-making in suicidal behaviour is often highlighted; however, the performance of persons in suicide crisis is unknown. This study aimed to explore the comprehensive decision-making profile of depressed patients following a suicide attempt. METHODS: Decision-making was measured by reward- ("ABCD") and punishment- ("EFGH") sensitive versions of the Iowa Gambling Task (IGT) in 59 medication-free depressed patients within 72 h after a suicide attempt and in 46 healthy control subjects...
April 16, 2018: Journal of Affective Disorders
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