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https://www.readbyqxmd.com/read/27923796/characterization-of-the-changes-in-cardiac-structure-and-function-in-mice-treated-with-anthracyclines-using-serial-cardiac-magnetic-resonance-imaging
#1
Hoshang Farhad, Pedro V Staziaki, Daniel Addison, Otavio R Coelho-Filho, Ravi V Shah, Richard N Mitchell, Balint Szilveszter, Siddique A Abbasi, Raymond Y Kwong, Marielle Scherrer-Crosbie, Udo Hoffmann, Michael Jerosch-Herold, Tomas G Neilan
BACKGROUND: Anthracyclines are cardiotoxic; however, there are limited data characterizing the serial changes in cardiac structure and function after anthracyclines. The aim of this study was to use cardiac magnetic resonance to characterize anthracycline-induced cardiotoxicity in mice. METHODS AND RESULTS: This was a longitudinal cardiac magnetic resonance and histological study of 45 wild-type male mice randomized to doxorubicin (n=30, 5 mg/kg of doxorubicin/week for 5 weeks) or placebo (n=15)...
December 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27922085/diversity-of-major-urinary-proteins-mups-in-wild-house-mice
#2
Michaela Thoß, Viktoria Enk, Hans Yu, Ingrid Miller, Kenneth C Luzynski, Boglarka Balint, Steve Smith, Ebrahim Razzazi-Fazeli, Dustin J Penn
Major urinary proteins (MUPs) are often suggested to be highly polymorphic, and thereby provide unique chemical signatures used for individual and genetic kin recognition; however, studies on MUP variability have been lacking. We surveyed populations of wild house mice (Mus musculus musculus), and examined variation of MUP genes and proteins. We sequenced several Mup genes (9 to 11 loci) and unexpectedly found no inter-individual variation. We also found that microsatellite markers inside the MUP cluster show remarkably low levels of allelic diversity, and significantly lower than the diversity of markers flanking the cluster or other markers in the genome...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27917674/-giant-sialolithiasis-diagnosis-and-management-case-reports
#3
Bálint Tordai, Nóra Stáczer, László Vajta, József Szalma
Sialolithiasis is one of the most frequent form of calcifications in the maxillofacial area. 0.45% of the population is affected by symptoms caused by salivary calculi, though the estimated frequency including asymptomatic form may exceed 1% in adult population. Radiographs presenting a large portion of the maxillofacial region (panoramic radiography, computed tomography) could detect salivary calculi with high accuracy. The size of the sialoliths is usually less than 10 mm in diameter. Salivary calculi larger than 15 mm (considering the largest diameter) are classified as giant sialoliths and most of them are located in the submandibular gland or in its duct...
December 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27898757/expanding-maize-genetic-resources-with-predomestication-alleles-maize-teosinte-introgression-populations
#4
Zhengbin Liu, Jason Cook, Susan Melia-Hancock, Katherine Guill, Christopher Bottoms, Arturo Garcia, Oliver Ott, Rebecca Nelson, Jill Recker, Peter Balint-Kurti, Sara Larsson, Nicholas Lepak, Ed Buckler, Loren Trimble, William Tracy, Michael D McMullen, Sherry A Flint-Garcia
Teosinte ( subsp. H. H. Iltis & Doebley) has greater genetic diversity than maize inbreds and landraces ( subsp. ). There are, however, limited genetic resources to efficiently evaluate and tap this diversity. To broaden resources for genetic diversity studies in maize, we developed and evaluated 928 near-isogenic introgression lines (NILs) from 10 teosinte accessions in the B73 background. Joint linkage analysis of the 10 introgression populations identified several large-effect quantitative trait loci (QTL) for days to anthesis (DTA), kernel row number (KRN), and 50-kernel weight (Wt50k)...
March 2016: Plant Genome
https://www.readbyqxmd.com/read/27896617/comprehensive-dna-methylation-and-mutation-analyses-reveal-a-methylation-signature-in-colorectal-sessile-serrated-adenomas
#5
Árpád V Patai, Barbara Kinga Barták, Bálint Péterfia, Tamás Micsik, Réka Horváth, Csaba Sumánszki, Zoltán Péter, Árpád Patai, Gábor Valcz, Alexandra Kalmár, Kinga Tóth, Tibor Krenács, Zsolt Tulassay, Béla Molnár
Colorectal sessile serrated adenomas (SSA) are hypothesized to be precursor lesions of an alternative, serrated pathway of colorectal cancer, abundant in genes with aberrant promoter DNA hypermethylation. In our present pilot study, we explored DNA methylation profiles and examined selected gene mutations in SSA. Biopsy samples from patients undergoing screening colonoscopy were obtained during endoscopic examination. After DNA isolation and quality analysis, SSAs (n = 4) and healthy controls (n = 5) were chosen for further analysis...
November 29, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27895948/pediatric-balint-s-syndrome-variant-a-possible-diagnosis-in-children
#6
Swetha Sara Philip, Sunithi Elizabeth Mani, Gordon N Dutton
Balint's syndrome is well described in adults, but not in children. It is caused by bilateral posterior parietal lobe damage and comprises a triad of simultanagnosia (inability to simultaneously see more than a small number of items), optic ataxia (impaired visual guidance of movement of the limbs and body), and apraxia of gaze (inability to volitionally direct gaze despite the requisite motor substrate) often associated with homonymous lower visual field loss. We, here, describe five children (four males, one female; mean age 7...
2016: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/27889980/-the-importance-of-free-nucleic-acids-in-the-non-invasive-diagnostics
#7
Bálint Nagy, Zoltán Csanádi, Róbert Póka
There is a great interest to determine the physiological role of "free" nucleic acids, and to use them in the clinical diagnostics. These could be DNA, mRNA, microRNA and long non-coding RNA molecules, they are in the body fluids, like serum, tear, saliva, etc. Their exact role in the normal and pathological physiological processes is still in the focus of the research, while their use in the diagnostics is becoming more and more important. The use of "free" DNA in the non-invasive prenatal diagnosis is the first clinical application of the new generation sequencers, these methods are able to reach 99...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27889978/-analysis-of-plantar-pressure-patterns-among-obese-population
#8
Eleonóra Leidecker, Péter Kellermann, Mónika Galambosné Tiszberger, Bálint Molics, Aliz Bohner-Beke, József Nyárády, János Kránicz
INTRODUCTION: Although the role of body weight on foot health and load has been widely documented in research, the effect of the extra load due to body weight on plantar pressure characteristics is not well known. AIM: The aim of this study was to evaluate the impact of obesity on plantar pressure patterns among the working-age population. METHOD: 180 participants were involved. Two groups were evaluated according to body mass index categories regarding eight regions of the plantar area, focusing on the following parameters: contact area, maximum pressure and peak pressure...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27875525/precision-medicine-in-cancer-challenges-and-recommendations-from-an-eu-funded-cervical-cancer-biobanking-study
#9
Sanne Samuels, Balazs Balint, Heiko von der Leyen, Philippe Hupé, Leanne de Koning, Choumouss Kamoun, Windy Luscap-Rondof, Ulrike Wittkop, Ksenia Bagrintseva, Marina Popovic, Atttila Kereszt, Els Berns, Gemma G Kenter, Ekaterina S Jordanova, Maud Kamal, Susy Scholl
BACKGROUND: Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality worldwide. CC pathogenesis is triggered when human papillomavirus (HPV) inserts into the genome, resulting in tumour suppressor gene inactivation and oncogene activation. Collecting tumour and blood samples is critical for identifying these genetic alterations. METHODS: BIO-RAIDs is the first prospective molecular profiling clinical study to include a substantial biobanking effort that used uniform high-quality standards and control of samples...
December 6, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27864740/expression-levels-of-warburg-effect-related-micrornas-correlate-with-each-other-and-that-of-histone-deacetylase-enzymes-in-adult-hematological-malignancies-with-emphasis-on-acute-myeloid-leukemia
#10
Zsuzsanna Gaál, Éva Oláh, László Rejtő, Bálint László Bálint, László Csernoch
Disruption of epigenetic regulation and characteristic metabolic alterations (known as the Warburg-effect) are well-known hallmarks of cancer. In our study we investigated the expression levels of microRNAs and histone deacetylase enzymes via RT-qPCR in bone marrow specimens of adult patients suffering from hematological malignancies (total cohort n = 40), especially acute myeloid leukemia (n = 27). The levels of the three examined Warburg-effect related microRNAs (miR-378*, miR-23b, miR-26a) positively correlated with each other and the oncogenic miR-155 and miR-125b, while negatively with the level of the tumorsuppressor miR-124...
November 18, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27858319/substrate-concentration-dependence-of-voltage-and-power-production-characteristics-in-two-chambered-mediator-less-microbial-fuel-cells-with-acetate-and-peptone-substrates
#11
Gábor Márk Tardy, Bálint Lóránt, Máté Lóka
OBJECTIVES: Power production characteristics and substrate concentration dependence of voltage have been investigated together with the determination of kinetic constants in two-chambered mediator-less microbial fuel cells (MFC) for acetate and peptone substrates. RESULTS: At 500 mg DOC l(-1) (dissolved organic carbon), power densities normalized to the anode surface of 112 mW m(-2) with acetate and 114 mW m(-2) with peptone as electron donor were attained by applying cathodes with a Pt catalyst layer...
November 17, 2016: Biotechnology Letters
https://www.readbyqxmd.com/read/27854159/sheehan-s-syndrome-and-sickle-cell-disease-the-story-of-natasha
#12
Barbara A Wilson, Anita Rose, Gerhard Florschutz
Sheehan's syndrome (SS) is one of the pituitary disorders caused by severe blood loss during childbirth leading to necrosis of the pituitary gland. Diagnosis is made following severe haemorrhage, failure to produce milk and failure to menstruate. Rare in countries with good obstetric care, SS is still frequent in those countries with poor healthcare services. The majority of papers published on SS do not mention psychological or neuropsychological sequelae. Of those that do, mood disorders are sometimes reported and occasionally cognitive problems are noted, typically attention, memory or executive deficits...
November 17, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27851894/complete-genome-sequence-of-novosphingobium-resinovorum-sa1-a-versatile-xenobiotic-degrading-bacterium-capable-of-utilizing-sulfanilic-acid
#13
Botond Hegedűs, Péter B Kós, Balázs Bálint, Gergely Maróti, Han Ming Gan, Katalin Perei, Gábor Rákhely
Sulfanilic acid (4-aminobenzenesulfonic acid) is a sulfonated aromatic amine widely used in chemical industries for synthesis of various organic dyes and sulfa drugs. There are quite a few microbial co-cultures or single isolates capable of completely degrading this compound. Novosphingobium resinovorum SA1 was the first single bacterium which could utilize sulfanilic acid as its sole carbon, nitrogen and sulfur source. The strain has versatile catabolic routes for the bioconversion of numerous other aromatic compounds...
November 13, 2016: Journal of Biotechnology
https://www.readbyqxmd.com/read/27849993/353-knowledge-of-european-high-school-students-on-resuscitation-and-first-aid-measures
#14
Attila Pandur, Balint Banfai, Henrietta Csonka, Emese Pek, Krisztine Deutsch, Jozsef Betlehem
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845539/review-of-clinical-uncertainty-in-primary-care-the-challenge-of-collaborative-engagement
#15
Jeffrey M Ring
Reviews the book, Clinical Uncertainty in Primary Care: The Challenge of Collaborative Engagement edited by Lucia Siegel Sommers and John Lautner (see record 2013-30484-000). The bulk of this book comprises a wide array of different models for collaborative uncertainty work. From Balint groups that help participants to tolerate uncertainty to narrative-based supervision that poses challenging self-reflective questions, each chapter provides a description of group intervention design, theoretical context, the structure for facilitation, and outcome data on impact...
March 2016: Families, Systems & Health: the Journal of Collaborative Family Healthcare
https://www.readbyqxmd.com/read/27835046/identifying-mirna-regulatory-mechanisms-in-preeclampsia-by-systems-biology-approaches
#16
Orsolya Biró, Bálint Nagy, János Rigó
BACKGROUND: Preeclampsia (PE) is the major cause of maternal and fetal morbidity and mortality, affecting 3-8% of all pregnancies around the globe. miRNAs are small, noncoding RNA molecules, which negatively regulate gene expression. Abnormally expressed miRNAs contribute to pregnancy complications such as PE. The aim of our study was to find possible regulatory mechanisms by system biology approaches, which are connected to the pathogenesis of PE. METHODS: We integrated publicly available miRNA and gene expression profiles and created a network from the significant miRNA-mRNA pairs with the help of MAGIA and Cytoscape softwares...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27834716/draft-genome-sequence-of-the-soil-isolate-lysinibacillus-fusiformis-m5-a-potential-hypoxanthine-producer
#17
Ramses Gallegos-Monterrosa, Gergely Maróti, Balázs Bálint, Ákos T Kovács
Lysinibacillus fusiformis strain M5 is a potential hypoxanthine producer that was isolated from clay soil. Here, we present the draft genome sequence that was annotated in order to facilitate future studies of L. fusiformis M5.
November 10, 2016: Genome Announcements
https://www.readbyqxmd.com/read/27832120/variability-of-the-structural-coloration-in-two-butterfly-species-with-different-prezygotic-mating-strategies
#18
Gábor Piszter, Krisztián Kertész, Zsolt Bálint, László Péter Biró
Structural coloration variability was investigated in two Blue butterfly species that are common in Hungary. The males of Polyommatus icarus (Common Blue) and Plebejus argus (Silver-studded Blue) use their blue wing coloration for conspecific recognition. Despite living in the same type of habitat, these two species display differences in prezygotic mating strategy: the males of P. icarus are patrolling, while P. argus males have sedentary behavior. Therefore, the species-specific photonic nanoarchitecture, which is the source of the structural coloration, may have been subjected to different evolutionary effects...
2016: PloS One
https://www.readbyqxmd.com/read/27830770/lineage-diversification-homo-and-heterologous-reassortment-and-recombination-shape-the-evolution-of-chicken-orthoreoviruses
#19
Szilvia L Farkas, Szilvia Marton, Eszter Dandár, Renáta Kugler, Bence Gál, Ferenc Jakab, Ádám Bálint, Sándor Kecskeméti, Krisztián Bányai
The near complete genome sequences of ten field avian orthoreovirus (ARV) strains collected from young chicken between 2002 and 2011 in Hungary have been determined in order to explore the genetic diversity and evolutionary mechanisms affecting ARVs in this region. Sequence analyses and phylogenetic calculations revealed similar geographic distribution and distinct evolution in case of eight studied strains that were closely related to the recently described Hungarian strain T1781. The remaining two strains showed the highest similarity with the US origin AVS-B...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827902/chiral-alkyl-halides-underexplored-motifs-in-medicine
#20
REVIEW
Bálint Gál, Cyril Bucher, Noah Z Burns
While alkyl halides are valuable intermediates in synthetic organic chemistry, their use as bioactive motifs in drug discovery and medicinal chemistry is rare in comparison. This is likely attributable to the common misconception that these compounds are merely non-specific alkylators in biological systems. A number of chlorinated compounds in the pharmaceutical and food industries, as well as a growing number of halogenated marine natural products showing unique bioactivity, illustrate the role that chiral alkyl halides can play in drug discovery...
November 4, 2016: Marine Drugs
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