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https://www.readbyqxmd.com/read/29329658/novel-compounds-with-potent-cdk9-inhibitory-activity-for-the-treatment-of-myeloma
#1
Zsófia Czudor, Mária Balogh, Péter Bánhegyi, Sándor Boros, Nóra Breza, Judit Dobos, Márk Fábián, Zoltán Horváth, Eszter Illyés, Péter Markó, Anna Sipos, Csaba Szántai-Kis, Bálint Szokol, László Őrfi
Cyclin-dependent kinases (CDKs) and Polo-like kinases (PLKs) play key role in the regulation of the cell cycle. The aim of our study was originally the further development of our recently discovered polo-like kinase 1 (PLK1) inhibitors. A series of new 2,4-disubstituted pyrimidine derivatives were synthesized around the original hit, but their PLK1 inhibitory activity was very poor. However the novel compounds showed nanomolar CDK9 inhibitory activity and very good antiproliferative effect on multiple myeloma cell lines (RPMI-8226)...
January 2, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29315873/dominance-of-free-wall-radial-motion-in-global-right-ventricular-function-of-heart-transplant-recipients
#2
Bálint Károly Lakatos, Márton Tokodi, Alexandra Assabiny, Zoltán Tősér, Annamária Kosztin, Alexandra Doronina, Kristóf Rácz, Kinga Bianka Koritsánszky, Viktor Berzsenyi, Endre Németh, Balázs Sax, Attila Kovács, Béla Merkely
Assessment of right ventricular (RV) function using conventional echocardiography might be inadequate as the radial motion of the RV free wall is often neglected. Our aim was to quantify the longitudinal and the radial components of RV function using three-dimensional (3D) echocardiography in heart transplant (HTX) recipients. 51 HTX patients in stable cardiovascular condition without history of relevant rejection episode or chronic allograft vasculopathy and 30 healthy volunteers were enrolled. RV end-diastolic (EDV) volume and total ejection fraction (TEF) were measured by 3D echocardiography...
January 8, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29310593/how-disease-extent-can-be-included-in-the-endoscopic-activity-index-of-ulcerative-colitis-the-panmayo-score-a-promising-scoring-system
#3
Anita Bálint, Klaudia Farkas, Zoltán Szepes, Ferenc Nagy, Mónika Szűcs, László Tiszlavicz, Renáta Bor, Ágnes Milassin, Mariann Rutka, Anna Fábián, Tamás Molnár
BACKGROUND: Colonoscopy plays crucial role in the establishment of the diagnosis, management and follow-up of ulcerative colitis (UC). None of the currently widely used endoscopic scores consider disease extent, and therefore do not correlate with the real severity of UC. Our aim was to assess the accuracy of a new score, the Pancolonic Modified Mayo Score that can reflect not only the severity, but the extent of active UC. METHODS: One hundred and four UC patients were enrolled in this prospective study...
January 8, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29308472/controlled-preparation-of-amphiphilic-triblock-copolyether-in-a-metal-and-solvent-free-approach-for-tailored-structure-directing-agents
#4
Alexander Balint, Marius Papendick, Manuel Clauss, Carsten Müller, Frank Giesselmann, Stefan Naumann
Under mild conditions, PPO-PEO-PPO ("reverse Pluronics") and PBO-PEO-PBO copolyether were generated by way of N-heterocyclic olefin-based organocatalysis. Reverse Pluronics with molar masses > 20 000 g mol-1 could be synthesized with excellent control (ĐM ≤ 1.03) and were converted into (ordered) mesoporous carbons via organic self-assembly to showcase the need for tailor-made copolymer as structure-directing agent.
January 8, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29308001/chronic-kidney-disease-severely-deteriorates-the-outcome-of-gastrointestinal-bleeding-a-meta-analysis
#5
Roland Hágendorn, Nelli Farkas, Áron Vincze, Zoltán Gyöngyi, Dezső Csupor, Judit Bajor, Bálint Erőss, Péter Csécsei, Andrea Vasas, Zsolt Szakács, László Szapáry, Péter Hegyi, Alexandra Mikó
AIM: To understand the influence of chronic kidney disease (CKD) on mortality, need for transfusion and rebleeding in gastrointestinal (GI) bleeding patients. METHODS: A systematic search was conducted in three databases for studies on GI bleeding patients with CKD or end-stage renal disease (ESRD) with data on outcomes of mortality, transfusion requirement, rebleeding rate and length of hospitalization (LOH). Calculations were performed with Comprehensive Meta-Analysis software using the random effects model...
December 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29307221/-rapid-first-tier-genetic-diagnosis-in-patients-with-prader-willi-syndrome
#6
Orsolya Dóra Ács, Bálint Péterfia, Péter Hollósi, Irén Haltrich, Ágnes Sallai, Andrea Luczay, Karin Buiting, Bernhard Horsthemke, Dóra Török, András Szabó, György Fekete
INTRODUCTION: According to the international literature, DNA methylation analysis of the promoter region of SNRPN locus is the most efficient way to start genetic investigation in patients with suspected Prader-Willi syndrome. AIM: Our aim was to develop a simple, reliable first-tier diagnosis to confirm Prader-Willi syndrome, therefore to compare our self-designed simple, cost-efficient high-resolution melting analysis and the most commonly used methylation-specific multiplex ligation-dependent probe amplification to confirm Prader-Willi syndrome...
January 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29307215/-peroral-and-transdermal-application-of-non-steroidal-anti-inflammatory-drugs-nsaids-for-the-treatment-of-regional-musculoskeletal-pain-syndromes
#7
László Hodinka, Géza Bálint, Erika Budai, Pál Géher, Renáta Papp, Péter Somogyi, Sándor Szántó, Edit Vereckei
In this review the available evidences regarding the most frequently applied medication (peroral and transdermal non-steroidal anti-inflammatory agents) for the most frequent musculoskeletal complaints (regional pain syndromes) have been collected for the appropriate medical professionals who are most frequently faced with these conditions (general practitioners, rheumatologists, orthopedics, occupational and sports medicine experts). The special population at risk (with repeated and high energy overuse because of occupational or sport activities) and the pathology of their syndromes are identified...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29305981/the-effect-of-formulation-additives-on-in-vitro-dissolution-absorption-profile-and-in-vivo-bioavailability-of-telmisartan-from-brand-and-generic-formulations
#8
Enikő Borbás, Zsombor K Nagy, Brigitta Nagy, Attila Balogh, Balázs Farkas, Oksana Tsinman, Konstantin Tsinman, Bálint Sinkó
In this study, brand and four generic formulations of telmisartan, an antihypertensive drug, were used in in vitro simultaneous dissolution-absorption, investigating the effect of different formulation additives on dissolution and on absorption through an artificial membrane. The in vitro test was found to be sensitive enough to show even small differences between brand and generic formulations caused by the use of different excipients. By only changing the type of filler from sorbitol to mannitol in the formulation, the flux through the membrane was reduced by approximately 10%...
January 3, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29290108/radical-thermometers-thermochemistry-and-photoelectron-spectra-a-pepico-study-of-the-methyl-peroxy-radical
#9
Krisztina Voronova, Kent M Ervin, Krisztián G Torma, Patrick Hemberger, Andras Bodi, Thomas Gerber, David L Osborn, Balint Sztaray
We investigated the simplest alkylperoxy radical, CH3OO, formed by reacting photolytically generated CH3 radicals with O2, using the new CRF-PEPICO apparatus at the Swiss Light Source. Modeling the experimental photoion mass-selected threshold photoelectron spectrum using Franck-Condon simulations including transitions to triplet and singlet cationic states yielded the adiabatic ionization energy of 10.265 ± 0.025 eV. Dissociative photoionization of CH3OO generates the CH3+ fragment ion at the appearance energy of 11...
December 31, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29285943/-assessment-of-sacroiliacal-joint-mobility-in-patients-with-low-back-pain
#10
Máté Burkus, István Márkus, Bálint Niklai, Miklós Tunyogi-Csapó
INTRODUCTION: Sagittal alignment of the pelvis is typically characterized using three fundamental parameters. Among these, pelvic incidence is traditionally considered to be anatomically 'constant'. AIM: We aimed to analyze the pelvic parameters of low back pain patients with suspected sacroiliac joint laxity. METHOD: Pelvic parameters were assessed in standing and seated EOS 2D/3D radiographs of 48 cases of persistent low back pain, and compared to upper body position using cluster analysis and t-test...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29282592/systematic-exploration-of-multiple-drug-binding-sites
#11
Mónika Bálint, Norbert Jeszenői, István Horváth, David van der Spoel, Csaba Hetényi
BACKGROUND: Targets with multiple (prerequisite or allosteric) binding sites have an increasing importance in drug design. Experimental determination of atomic resolution structures of ligands weakly bound to multiple binding sites is often challenging. Blind docking has been widely used for fast mapping of the entire target surface for multiple binding sites. Reliability of blind docking is limited by approximations of hydration models, simplified handling of molecular flexibility, and imperfect search algorithms...
December 28, 2017: Journal of Cheminformatics
https://www.readbyqxmd.com/read/29262296/electroactive-biomaterials-vehicles-for-controlled-delivery-of-therapeutic-agents-for-drug-delivery-and-tissue-regeneration
#12
Biranche Tandon, Adrián Magaz, Richard Balint, Jonny J Blaker, Sarah H Cartmell
Electrical stimulation for delivery of biochemical agents such as genes, proteins and RNA molecules amongst others, holds great potential for controlled therapeutic delivery and in promoting tissue regeneration. Electroactive biomaterials have the capability of delivering these agents in a localized, controlled, responsive and efficient manner. These systems have also been combined for the delivery of both physical and biochemical cues and can be programmed to achieve enhanced effects on healing by establishing control over the microenvironment...
December 17, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29251729/virus-stamping-for-targeted-single-cell-infection-in-vitro-and-in-vivo
#13
Rajib Schubert, Stuart Trenholm, Kamill Balint, Georg Kosche, Cameron S Cowan, Manuel A Mohr, Martin Munz, David Martinez-Martin, Gotthold Fläschner, Richard Newton, Jacek Krol, Brigitte Gross Scherf, Keisuke Yonehara, Adrian Wertz, Aaron Ponti, Alexander Ghanem, Daniel Hillier, Karl-Klaus Conzelmann, Daniel J Müller, Botond Roska
Genetic engineering by viral infection of single cells is useful to study complex systems such as the brain. However, available methods for infecting single cells have drawbacks that limit their applications. Here we describe 'virus stamping', in which viruses are reversibly bound to a delivery vehicle-a functionalized glass pipette tip or magnetic nanoparticles in a pipette-that is brought into physical contact with the target cell on a surface or in tissue, using mechanical or magnetic forces. Different single cells in the same tissue can be infected with different viruses and an individual cell can be simultaneously infected with different viruses...
December 18, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29235909/the-role-of-balint-group-training-in-the-professional-and-personal-development-of-family-medicine-residents
#14
Marty Player, John R Freedy, Vanessa Diaz, Clive Brock, Alexander Chessman, Carolyn Thiedke, Alan Johnson
This paper presents a study based on the participation of PGY2 and PGY3 family medicine residents in Balint seminars that occurred twice monthly for 24 months. Balint groups were cofacilitated by leader pairs experienced with the Balint method. Prior to residency graduation, 18 of 19 eligible resident physicians (94.5%) completed 30- to 60-min semistructured interviews conducted by a research assistant. Resident physicians were told that these individual interviews concerned "…how we teach communication in residency...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235409/engaging-indigenous-maori-and-inward-migrating-asian-professionals-into-a-pakeha-white-european-dominated-balint-community-in-new-zealand
#15
Timothy McMichael
This inquiry began with two questions: How can the established predominately Pakeha/Caucasian (White European) Balint community in New Zealand more successfully engage both indigenous populations of both Maori and Pacifica origin into Balint work? And what is the existing Balint community doing to address the lack of Asian members of the Balint community in New Zealand, at a time when Asian health professionals are being recruited into the health sector at an increasingly high rate in comparison to White European entrants to the profession? These questions, and their preliminary answers presented here, invite the reader to reflect on both the challenges and opportunities in reaching out to groups different from our own...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235408/balint-work-and-the-creation-of-medical-knowledge
#16
John Muench
Michael Balint's pioneering work in primary care was not simply the application of psychodynamic theory to the complex problems and relationships encountered by clinicians. Rather, Balint's work was part of a wider conversation in Western epistemology that had already begun to break down the enlightenment rationalist agenda. Since the time of Descartes, we sought to find certain truth through decontextualizing and abstracting problems, and through separation of the observer from the thing observed, with a focus on finding universal timeless laws that could be generalized...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235407/creation-of-a-curriculum-for-the-balint-group-leader-education-fellowship
#17
Laurel Milberg, Albert Lichtenstein
No abstract text is available yet for this article.
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29235405/mapping-the-balint-groups-to-the-accreditation-council-for-graduate-medical-education-family-medicine-competencies
#18
Albert Lichtenstein, Jumana Antoun, Chris Rule, Katherine Knowlton, Jeffrey Sternlieb
Introduction Balint group discussions provide learning opportunities for many of the competencies and milestones put forward by the Accreditation Council for Graduate Medical Education. The current literature is mixed concerning the effect of Balint groups on communication skills and professionalism. Aim To map the content of the Balint discussion to the competencies and milestones put forward by the Accreditation Council for Graduate Medical Education. METHODOLOGY: A group who were both experts in Balint and members of the clinical competency committee of residency programs rated narratives that summarized Balint group discussions...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29233836/radiomic-features-are-superior-to-conventional-quantitative-computed-tomographic-metrics-to-identify-coronary-plaques-with-napkin-ring-sign
#19
Márton Kolossváry, Júlia Karády, Bálint Szilveszter, Pieter Kitslaar, Udo Hoffmann, Béla Merkely, Pál Maurovich-Horvat
BACKGROUND: Napkin-ring sign (NRS) is an independent prognostic imaging marker of major adverse cardiac events. However, identification of NRS is challenging because of its qualitative nature. Radiomics is the process of extracting thousands of quantitative parameters from medical images to create big-data data sets that can identify distinct patterns in radiological images. Therefore, we sought to determine whether radiomic analysis improves the identification of NRS plaques. METHODS AND RESULTS: From 2674 patients referred to coronary computed tomographic angiography caused by stable chest pain, expert readers identified 30 patients with NRS plaques and matched these with 30 non-NRS plaques with similar degree of calcification, luminal obstruction, localization, and imaging parameters...
December 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29226753/balint-under-the-microscope-what-really-happens-in-balint-groups
#20
John Salinsky
No abstract text is available yet for this article.
January 1, 2017: International Journal of Psychiatry in Medicine
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