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https://www.readbyqxmd.com/read/28637499/diagnostic-relevance-of-urinary-steroid-profiles-on-ovarian-granulosa-cell-tumors-two-case-reports
#1
Anita Bufa, Nelli Farkas, Zsolt Preisz, Viktória Poór, Csilla Páger, Sándor Szukits, Bálint Farkas, Péter Miklós Gőcze
BACKGROUND: Granulosa cell tumor of the ovary is the most frequent sex cord stromal tumor and represents 2 to 5% of all primary ovarian cancers. Ovarian granulosa cell tumor is a malignant tumor with slow progression and in some cases this tumor is hormonally active. The recurrence of granulosa cell tumor often happens after 5 years. CASE PRESENTATION: We describe two cases of postmenopausal women with adult-type granulosa cell tumors of the ovary. Patient 1 is a 49-year-old European woman with a recurrent tumor; patient 2 is a 55-year-old European woman without recurrence of tumor...
June 22, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28632738/correction-phenotypic-heterogeneity-promotes-adaptive-evolution
#2
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
June 2017: PLoS Biology
https://www.readbyqxmd.com/read/28621642/spectrum-and-antibiotic-resistance-of-uropathogens-between-2004-and-2015-in-a-tertiary-care-hospital-in-hungary
#3
András Magyar, Béla Köves, Károly Nagy, András Dobák, Vinodh Kumar Adithyaa Arthanareeswaran, Péter Bálint, Florian Wagenlehner, Péter Tenke
PURPOSE: Surveillance of the bacterial spectrum and antibiotic-resistance patterns of locally occurring uropathogens is essential to serve as a basis for empirical treatment of urinary tract infections (UTIs), as antibiotic-resistance rates may vary geographically with significant differences between countries and regions, and with time. METHODOLOGY: We retrospectively analysed all urine samples taken in the department of urology in a tertiary care hospital in Hungary from January 2004 to December 2015...
June 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28621190/-watermelon-stomach-can-be-the-cause-of-severe-gastrointestinal-bleeding
#4
István Sugár, Zoltán Ráth, Pál Ondrejka, Zsolt Iványi, Bálint Scheich, Judit Várkonyi
Irregular vascular dilatation in the antrum or the cardia of the stomach can be the cause of severe gastrointestinal bleeding. The first term for it - in the beginning of the 50's of the previous century - was GAVE (Gastric Antral Vascular Ectasia) since at that time no similar phenomenon had been registered before. A quarter of a century later, after publishing a few cases, a witty internist described it as "watermelon stomach" because the macroscopic picture is similarly looking as the aforesaid fruit's appearing...
June 2017: Magyar Sebészet
https://www.readbyqxmd.com/read/28618599/grain-coarsening-in-two-dimensional-phase-field-models-with-an-orientation-field
#5
Bálint Korbuly, Tamás Pusztai, Hervé Henry, Mathis Plapp, Markus Apel, László Gránásy
In the literature, contradictory results have been published regarding the form of the limiting (long-time) grain size distribution (LGSD) that characterizes the late stage grain coarsening in two-dimensional and quasi-two-dimensional polycrystalline systems. While experiments and the phase-field crystal (PFC) model (a simple dynamical density functional theory) indicate a log-normal distribution, other works including theoretical studies based on conventional phase-field simulations that rely on coarse grained fields, like the multi-phase-field (MPF) and orientation field (OF) models, yield significantly different distributions...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28611956/comparative-genomic-and-phylogenetic-analysis-of-a-shiga-toxin-producing-shigella-sonnei-stss-strain
#6
Domonkos Sváb, Balázs Bálint, Bálint Vásárhelyi, Gergely Maróti, István Tóth
Shigella strains are important agents of bacillary dysentery, and in recent years Shigella sonnei has emerged as the leading cause of shigellosis in industrialized and rapidly developing countries. More recently, several S. sonnei and Shigella flexneri strains producing Shiga toxin (Stx) have been reported from sporadic cases and from an outbreak in America. In the present study we aimed to shed light on the evolution of a recently identified Shiga toxin producing S. sonnei (STSS) isolated in Europe. Here we report the first completely assembled whole genome sequence of a multidrug resistant (MDR) Stx-producing S...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28610604/age-and-environment-dependent-changes-in-chemical-defences-of-larval-and-post-metamorphic-toads
#7
Bálint Üveges, Gábor Fera, Ágnes M Móricz, Dániel Krüzselyi, Veronika Bókony, Attila Hettyey
BACKGROUND: Chemical defences are widespread in animals, but how their production is adjusted to ecological conditions is poorly known. Optimal defence theory predicts that inducible defences are favoured over constitutive defences when toxin production is costly and the need for it varies across environments. However, if some environmental changes occur predictably (e.g. coupled to transitions during ontogeny), whereas others are unpredictable (e.g. predation, food availability), changes in defences may have constitutive as well as plastic elements...
June 13, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28587671/integrative-taxonomy-by-molecular-species-delimitation-multi-locus-data-corroborate-a-new-species-of-balkan-drusinae-micro-endemics
#8
Simon Vitecek, Mladen Kučinić, Ana Previšić, Ivana Živić, Katarina Stojanović, Lujza Keresztes, Miklós Bálint, Felicitas Hoppeler, Johann Waringer, Wolfram Graf, Steffen U Pauls
BACKGROUND: Taxonomy offers precise species identification and delimitation and thus provides basic information for biological research, e.g. through assessment of species richness. The importance of molecular taxonomy, i.e., the identification and delimitation of taxa based on molecular markers, has increased in the past decade. Recently developed exploratory tools now allow estimating species-level diversity in multi-locus molecular datasets. RESULTS: Here we use molecular species delimitation tools that either quantify differences in intra- and interspecific variability of loci, or divergence times within and between species, or perform coalescent species tree inference to estimate species-level entities in molecular genetic datasets...
June 6, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28582455/correction-myosin-phosphatase-and-rhoa-activated-kinase-modulate-neurotransmitter-release-by-regulating-snap-25-of-snare-complex
#9
Dániel Horváth, István Tamás, Adrienn Sipos, Zsuzsanna Darula, Bálint Bécsi, Dénes Nagy, Judit Iván, Ferenc Erdődi, Beáta Lontay
[This corrects the article DOI: 10.1371/journal.pone.0177046.].
2017: PloS One
https://www.readbyqxmd.com/read/28578692/comprehensive-dna-methylation-study-identifies-novel-progression-related-and-prognostic-markers-for-cutaneous-melanoma
#10
Jasper Wouters, Miguel Vizoso, Anna Martinez-Cardus, F Javier Carmona, Olivier Govaere, Teresa Laguna, Jesuchristopher Joseph, Peter Dynoodt, Claudia Aura, Mona Foth, Roy Cloots, Karin van den Hurk, Balazs Balint, Ian G Murphy, Enda W McDermott, Kieran Sheahan, Karin Jirström, Bjorn Nodin, Girish Mallya-Udupi, Joost J van den Oord, William M Gallagher, Manel Esteller
BACKGROUND: Cutaneous melanoma is the deadliest skin cancer, with an increasing incidence and mortality rate. Currently, staging of patients with primary melanoma is performed using histological biomarkers such as tumor thickness and ulceration. As disruption of the epigenomic landscape is recognized as a widespread feature inherent in tumor development and progression, we aimed to identify novel biomarkers providing additional clinical information over current factors using unbiased genome-wide DNA methylation analyses...
June 5, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28572713/specific-gene-and-microrna-expression-pattern-contributes-to-the-epithelial-to-mesenchymal-transition-in-a-rat-model-of-experimental-colitis
#11
Éva Boros, Marianna Csatári, Csaba Varga, Balázs Bálint, István Nagy
The aim of this study was to determine the gene- and microRNA-expression profile contributing to epithelial to mesenchymal transition in a rat model of experimental colitis. For this, inflammation was induced by injecting 2,4,6-trinitrobenzene sulphonic acid to the colon of male Wistar rats. Samples were taken from both inflamed and uninflamed regions of the same colon, total RNA was isolated, and the mRNA and microRNA expressions were monitored. We have determined that the expression of genes responsible for inducing mesenchymal phenotype, such as Egr1, Fgf2, Fgf7, Jak2, Notch2, Hif1α, Zeb2, Mmp9, Lox, and Vim, was all significantly induced in the inflamed regions of the affected colons while the epithelial marker E-cadherin (Cdh1) was downregulated...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28566609/progressive-b%C3%A3-lint-s-syndrome-in-a-patient-demonstrating-dementia-with-lewy-bodies
#12
Yasuhisa Sakurai, Yoshifumi Nakashima
We herein report a 65-year-old man demonstrating dementia with Lewy bodies who first presented with Bálint's syndrome. Two years later, a mild cognitive impairment was noted. From three years after onset, he developed progressive parkinsonism, visual hallucination, and autonomic dysfunction, in line with the deterioration of the cognitive function. Single photon emission computed tomography with a (99m)Tc-ethylcysteinate dimer performed two years after onset revealed hypoperfusion in the restricted area of the bilateral superior parietal lobule, which extended to the lateral occipital cortices within two years...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28555201/reconstruction-of-horizontovertical-alveolar-defects-presentation-of-a-novel-split-thickness-flap-design-%C3%A2-for-guided-bone-regeneration-%C3%A2-a-case-report-with-5-year-follow-up
#13
Peter Windisch, Anna Martin, Arvin Shahbazi, Balint Molnar
OBJECTIVE: To introduce a novel split-thickness flap design without periosteal and vertical releasing incisions for horizontovertical ridge augmentation. METHOD AND MATERIALS: Three patients with generalized chronic periodontitis presented posterior partial edentulism with class C alveolar defects according to the horizontal, vertical, and combination (HVC) classification. In all three cases, implant placement and simultaneous horizontovertical ridge augmentation utilizing a novel split-thickness flap design was performed...
2017: Quintessence International
https://www.readbyqxmd.com/read/28549421/comparison-of-vividtrac%C3%A2-airtraq%C3%A2-king-vision%C3%A2-macintosh-laryngoscope-and-a-custom-made-videolaryngoscope-for-difficult-and-normal-airways-in-mannequins-by-novices
#14
Szilárd Rendeki, Dóra Keresztes, Gábor Woth, Ákos Mérei, Martin Rozanovic, Mátyás Rendeki, József Farkas, Diána Mühl, Bálint Nagy
BACKGROUND: Direct laryngoscopy remains the gold standard for endotracheal intubation and is preferred by experienced operators. However, an increasing number of reports currently support videolaryngoscopy, particularly for novice users. The widespread use of videolaryngoscopy may be limited due to financial limitations, especially in low-income countries. Therefore, affordable single-use scopes are now becoming increasingly popular. We sought to compare these new scopes with direct laryngoscopes and the previously tested videolaryngoscopes in mannequins by novices...
May 26, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/28540480/the-effect-of-four-phasic-versus-three-phasic-contrast-media-injection-protocols-on-extravasation-rate-in-coronary-ct-angiography-a-randomized-controlled-trial
#15
Júlia Karády, Alexisz Panajotu, Márton Kolossváry, Bálint Szilveszter, Ádám L Jermendy, Andrea Bartykowszki, Mihály Károlyi, Csilla Celeng, Béla Merkely, Pál Maurovich-Horvat
OBJECTIVES: Contrast media (CM) extravasation is a well-known complication of CT angiography (CTA). Our prospective randomized control study aimed to assess whether a four-phasic CM administration protocol reduces the risk of extravasation compared to the routinely used three-phasic protocol in coronary CTA. METHODS: Patients referred to coronary CTA due to suspected coronary artery disease were included in the study. All patients received 400 mg/ml iomeprol CM injected with dual-syringe automated injector...
May 24, 2017: European Radiology
https://www.readbyqxmd.com/read/28506470/coronary-ct-angiography-in-the-emergency-department-utilizing-second-and-third-generation-dual-source-ct
#16
Nandini M Meyersohn, Balint Szilveszter, Pedro V Staziaki, Jan-Erik Scholtz, Richard A P Takx, Udo Hoffmann, Brian B Ghoshhajra
BACKGROUND: Coronary computed tomography angiography (coronary CTA) allows efficient triage of low to intermediate risk patients with suspected acute coronary syndrome (ACS) in the emergency department (ED). Techniques for coronary CTA acquisition in the ED continue to evolve with the establishment of standardized scan protocols and the introduction of newer generations of CT hardware. OBJECTIVES: To evaluate qualitative and quantitative image quality and radiation dose exposure of coronary CTA acquired on 2nd versus 3rd generation dual source CT (DSCT) scanners using a standardized institutional scan protocol designed for the ED...
July 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28504555/frequency-and-characteristics-of-infusion-reactions-during-biosimilar-infliximab-treatment-in-inflammatory-bowel-diseases-results-from-central-european-nationwide-cohort
#17
Anita Bálint, Mariann Rutka, Zsuzsanna Végh, Zsuzsanna Kürti, Krisztina B Gecse, János Banai, László Bene, Beáta Gasztonyi, Tünde Kristóf, László Lakatos, Pál Miheller, Károly Palatka, Árpád Patai, Ágnes Salamon, Tamás Szamosi, Zoltán Szepes, Gábor Tamás Tóth, Áron Vincze, Renáta Bor, Ágnes Milassin, Anna Fábián, Ferenc Nagy, Martin Kolar, Martin Bortlik, Dana Duricova, Veronika Hruba, Martin Lukas, Katarina Mitrova, Karin Malickova, Milan Lukas, Péter L Lakatos, Tamás Molnár, Klaudia Farkas
BACKGROUND: Safety data of the 'real life' use of an infliximab biosimilar, CT-P13 in inflammatory bowel disease (IBD) are still lacking. Our aim was to assess the frequency and characteristics of infusion reactions during CT-P13 therapy in 13 Hungarian and 1 Czech IBD centres. METHODS: Clinical and safety data was registered at fixed appointments. Trough levels and anti-drug antibody (ADA) concentration were measured by ELISA. Association between demographic, clinical, laboratory parameters and infusion reaction rates were evaluated statistically...
May 26, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28498330/specific-microrna-pattern-in-colon-tissue-of-young-children-with-eosinophilic-colitis
#18
Zoltán Kiss, Nóra Judit Béres, Erna Sziksz, Bálint Tél, Katalin Borka, András Arató, Attila J Szabó, Gábor Veres
Eosinophilic colitis (EC) is a common cause of haematochezia in infants and young children. The exact pathomechanism is not understood, and the diagnosis is challenging. The role of microRNAs as key class of regulators of mRNA expression and translation in patients with EC has not been explored. Therefore, the aim of the present study was to explore the miRNA profile in EC with respect to eosinophilic inflammation. Patients enrolled in the study (n = 10) had persistent rectal bleeding, and did not respond to elimination dietary treatment...
May 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28486561/myosin-phosphatase-and-rhoa-activated-kinase-modulate-neurotransmitter-release-by-regulating-snap-25-of-snare-complex
#19
Dániel Horváth, István Tamás, Adrienn Sipos, Zsuzsanna Darula, Bálint Bécsi, Dénes Nagy, Judit Iván, Ferenc Erdődi, Beáta Lontay
Reversible phosphorylation of neuronal proteins plays an important role in the regulation of neurotransmitter release. Myosin phosphatase holoenzyme (MP) consists of a protein phosphatase-1 (PP1) catalytic subunit (PP1c) and a regulatory subunit, termed myosin phosphatase targeting subunit (MYPT1). The primary function of MP is to regulate the phosphorylation level of contractile proteins; however, recent studies have shown that MP is localized to neurons, and is also involved in the mediation of neuronal processes...
2017: PloS One
https://www.readbyqxmd.com/read/28486496/phenotypic-heterogeneity-promotes-adaptive-evolution
#20
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (or plasticity) accelerates the rate of adaptive evolution in populations facing extreme environmental challenges. This issue is important as cell-to-cell phenotypic heterogeneity may initiate key steps in microbial evolution of drug resistance and cancer progression...
May 2017: PLoS Biology
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