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https://www.readbyqxmd.com/read/29330647/absence-of-the-nitrous-oxide-reductase-gene-cluster-in-commercial-alfalfa-inoculants-is-probably-due-to-the-extensive-loss-of-genes-during-rhizobial-domestication
#1
Silvina Brambilla, Romina Frare, Gabriela Soto, Cintia Jozefkowicz, Nicolás Ayub
As other legume crops, alfalfa cultivation increases the emission of the greenhouse gas nitrous oxide (N2O). Since legume-symbiotic nitrogen-fixing bacteria play a crucial role in this emission, it is important to understand the possible impacts of rhizobial domestication on the evolution of denitrification genes. In comparison with the genomes of non-commercial strains, those of commercial alfalfa inoculants exhibit low total genome size, low number of ORFs and high numbers of both frameshifted genes and pseudogenes, suggesting a dramatic loss of genes during bacterial domestication...
January 12, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29329462/silibinin-from-silybum-marianum-stimulates-embryonic-stem-cell-vascular-differentiation-via-the-stat3-pi3-k-akt-axis-and-nitric-oxide
#2
Enas Hussein Ali, Fatemeh Sharifpanah, Maria Wartenberg, Heinrich Sauer
Silibinin, the bioactive compound of milk thistle (Silybum marianum), exerts tissue protective and regenerative effects that may include stem cell differentiation toward vascular cells. The purpose of the present study was to investigate whether silibinin stimulates blood vessel formation from mouse embryonic stem (ES) cells and to unravel the underlying signaling cascade. Vascular branching points were assessed by confocal laser scanning microscopy and computer-assisted image analysis of CD31-positive cell structures...
January 12, 2018: Planta Medica
https://www.readbyqxmd.com/read/29323057/hypoxia-induced-factor-1-alpha-vascular-endothelial-growth-factor-expression-in-brca1-related-breast-cancer-a-prospective-study-in-tertiary-care-hospital
#3
Manisha Sharma, Sanjay Piplani, Manas Madan, Mridu Manjari, Saumil Garg, Komalpreet Kaur
INTRODUCTION: Breast cancer is the commonest cause of death among middle aged women. BRCA1 associated tumors carry a poor prognosis. Angiogenesis is considered necessary for tumor growth and for its metastasis. Hypoxia stimulates HIF-1α which then activates transcription of various proangiogenic cytokines like VEGF. In the present study we examined HIF-1α expression, sVEGF levels and BRCA1 mutations and their relation with clinicopathological parameters. We also determined whether the angiogenic markers have different role in angiogenesis in BRCA1 related cancers as compared to sporadic breast cancers...
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29322781/ab-initio-study-predicts-that-enigmatic-isonitrosyl-fluoride-should-be-stable-at-low-temperatures-yet-unnoticeable-due-to-its-photoreactivity
#4
Raulia R Syrlybaeva, Marat R Talipov
Isonitrosyl fluoride F-ON remains an undetected molecule despite multiple attempts to generate it and successful identification of other isonitrosyl halides (X-ONs) via photo-transformations of corresponding X-NOs. We investigated this problem using ab initio methods and found no evidence of instability of F-ON at low temperatures of 8-10 K. Instead, experimental observation of F-ON is likely challenged by the (1) different nature of photoexcitation of F-NO and its lower quantum yield than in other X-NOs, and (2) presence of a bright charge-transfer transition in the F-ON spectrum that likely overlaps with the weak band of F-NO used for photoexcitation...
January 11, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29321984/effects-of-bhramari-pranayama-on-health-a-systematic-review
#5
REVIEW
Maheshkumar Kuppusamy, Dilara Kamaldeen, Ravishankar Pitani, Julius Amaldas, Poonguzhali Shanmugam
Pranayama, a branch of yoga practice is extremely beneficial to mankind in maintaining sound physical and mental health and this article aims to attain an insight on the studies conducted on the effectiveness of Bhramari Pranayama (Bhr.P) on health. The studies done until May 2016 were found using Medline, Embase, Google scholar and manual search. Studies conducted on the health effectiveness of Bhr.P specifically were included on the basis of prisma guidelines. The data were defined by their objectives, methodology, study setting, findings, interventions done and implications suggested in the study...
January 2018: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/29320752/the-value-of-detection-of-s100a8-and-asah1-in-predicting-the-chemotherapy-response-for-breast-cancer-patients
#6
Yu-Hong Li, Hai-Ting Liu, Jing Xu, Ai-Yan Xing, Jie Zhang, Ya-Wen Wang, Gang Yin, Peng Gao
Chemotherapy plays an important role in the treatment of breast cancer. However, chemoresistance remains the main obstacle for effective treatment, leading to poor prognosis. This study aims to investigate the value of detection of S100A8 and ASAH1 in predicting the chemotherapy response. Miller and Payne grades were used to assess the chemotherapy response in breast cancers. The expression of S100A8 and ASAH1, as well as ER, PR, HER-2 and Ki-67 were assessed by immunohistochemical staining in 120 cases of non-special type invasive ductal carcinoma (IDC-NOS)...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29320163/reaction-intermediates-of-nitric-oxide-synthase-from-deinococcus-radiodurans-as-revealed-by-pulse-radiolysis-evidence-for-intramo-lecular-electron-transfer-from-biopterin-to-feii-o2-complex
#7
Yuko Tsutsui, Kazuo Kobayashi, Fusako Takeuchi, Motonari Tsubaki, Takahiro Kozawa
Nitric oxide synthase (NOS) is a cytochrome P450-type mono-oxygenase that catalyzes the oxidation of L-arginine (Arg) to nitric oxide (NO) through a reaction intermediate N-hydroxy-L-arginine (NHA). The mechanism underlying the reaction catalyzed by NOS from Deinococcus radiodurans was investigated using pulse radiolysis. Radiolytically-generated hydrated electrons reduced the heme iron of NOS within 2 μs. Subsequently, ferrous heme reacted with O2 to form a ferrous-dioxygen intermediated with a second-order rate constant of 2...
January 10, 2018: Biochemistry
https://www.readbyqxmd.com/read/29318854/-effect-of-electroacupuncture-on-intracellular-calcium-ion-concentration-and-expression-of-calcium-calmodulin-dependent-protein-kinase-%C3%A2-in-lumbar-spinal-cord-in-rats-with-neuropathic-pain
#8
Xin-Tian Wu, Wei Liang, Li-Ping Yan, Ling-Ling Wang, Cheng Ma
OBJECTIVE: To observe the changes of intracellular calcium ([Ca2+]i) concentration and expression of calcium/calmodulin dependent protein kinaseⅡ (CaMKⅡ) in spinal dorsal horn neurons of spared nerve injury (SNI) rats, so as to explore its mechanisms underlying improvement of neuropathic pain. METHODS: One hundred and ten SD rats were randomly divided into 5 groups: sham control, model, EA, AP-5 and L-NAME groups. The sham group underwent only a simple separation of the sciatic nerve but without ligation and abscission...
December 25, 2017: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29318755/sugar-intake-by-type-added-vs-naturally-occurring-and-physical-form-liquid-vs-solid-and-its-varying-association-with-children-s-body-weight-nhanes-2009-2014
#9
J A Welsh, Y Wang, J Figueroa, C Brumme
BACKGROUND: Sugars and their primary dietary sources (milk, fruits, sweetened foods and beverages) are associated, in different ways, with a range of health outcomes, including obesity. The contribution made to total sugar intake and how the different types and forms of sugar associate with body weight is unclear. OBJECTIVE: To describe sugar consumption and examine its association with weight status among U.S. children by sugar type [added {AS} vs. naturally occurring {NOS}] and form (solid vs...
January 9, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29313212/hyperbaric-oxygen-attenuates-withdrawal-symptoms-by-regulating-monoaminergic-neurotransmitters-and-no-signaling-pathway-at-nucleus-accumbens-in-morphine-dependent-rats
#10
Chunxia Chen, Qiuping Fan, Zhihuan Nong, Wan Chen, Yaoxuan Li, Luying Huang, Daorong Feng, Xiaorong Pan, Shengyong Lan
In this study, we examined whether hyperbaric oxygen (HBO2) plays a detoxification role in withdrawal symptoms in a morphine-dependent rat model. The model was established through injections of morphine at increasing doses for 7 days. Withdrawal symptoms were induced by naloxone injection on the 8th day. The detoxification effect of HBO2 was evaluated using the withdrawal symptom scores, biochemical indices and neurotransmitters. Compared with the model group, HBO2 therapy significantly attenuated the withdrawal symptom scores, body weight loss and the level of norepinephrine level, whereas it increased the dopamine level and tyrosine hydroxylase expression in the nucleus accumbens...
January 8, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29309904/regulator-of-calcineurin-1-modulates-vascular-contractility-and-stiffness-through-the-upregulation-of-cox-2-derived-prostanoids
#11
Ana B García-Redondo, Vanesa Esteban, Ana M Briones, Lucía S Díaz Del Campo, María González-Amor, Nerea Méndez-Barbero, Miguel R Campanero, Juan M Redondo, Mercedes Salaices A
Cyclooxygenase-2 (COX-2) derived-prostanoids participate in the altered vascular function and mechanical properties in cardiovascular diseases. We investigated whether regulator of calcineurin 1 (Rcan1) participates in vascular contractility and stiffness through the regulation of COX-2. For this, wild type (Rcan1+/+) and Rcan1-deficient (Rcan1-/-) mice untreated or treated with the COX-2 inhibitor rofecoxib were used. Vascular function and structure were analysed by myography. COX-2 and phospo-p65 expression were studied by western blotting and immunohistochemistry and TXA2 production by ELISA...
January 5, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29309810/cytoprotective-effect-of-deferiprone-against-aluminum-chloride-induced-oxidative-stress-and-apoptosis-in-lymphocytes
#12
Cuicui Zhuang, Yue She, Haiyang Zhang, Miao Song, Yanfei Han, Yanfei Li, Yanzhu Zhu
Aluminum (Al) is a toxic metal, and excessive Al accumulation causes immunosuppression. Deferiprone (DFP) is a well-known chelator and used in dialysis patients for removing Al from tissues. The present study aimed to investigate whether DFP treatment can attenuate immunotoxicity induced by aluminum chloride (AlCl3) in cultured lymphocytes. Lymphocytes were treated with 0 and 0.6 mmol/L AlCl3∙6H2O (pH 7.2) and/or 1.8 mmol/L DFP, respectively. Immune function of lymphocytes was assessed by T and B lymphocytes proliferation rates, T lymphocyte subpopulations and IL-2, IL-6 and TNF-α contents...
January 5, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29309240/2018-changing-our-publication-policies-to-emphasize-value-of-case-reports-2018-modifier-nos-politiques-de-publication-pour-souligner-la-valeur-des-rapports-de-cas
#13
Kirk Barber
No abstract text is available yet for this article.
January 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29308755/-hypophosphatemia-is-associated-with-poor-prognosis-of-critically-ill-patients-a-meta-analysis-of-1-555-patients
#14
Bo Liu, Yumei Cheng, Feng Shen, Yahui Wang, Yanqi Wu, Ling Yao, Yuqing Liu, Xianbi Gou
OBJECTIVE: To evaluate the relationship between hypophosphatemia and prognosis in critically ill patients. METHODS: Some hypophosphatemia-associated prospective or retrospective clinical cohort studies were searched through CNKI, Wanfang Data, PubMed, Embase, Cochrane library, and Google Scholar English database respectively, with the guidance of these key words such as hypophosphatemia, intensive care, prognosis and fatality rate. The articles were concerned about the correlation between hypophosphatemia and the prognosis of patients in intensive care unit (ICU)...
January 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29308071/positive-correlation-of-airway-resistance-and-serum-asymmetric-dimethylarginine-adma-in-bronchial-asthma-patients-lacking-evidence-for-systemic-inflammation
#15
Gabor Tajti, Csaba Papp, Laszlo Kardos, Sandor Keki, Krisztian Pak, Magdolna Emma Szilasi, Rudolf Gesztelyi, Angela Mikaczo, Andrea Fodor, Maria Szilasi, Judit Zsuga
Background: Contribution of nitric-oxide (NO) pathway to the pathogenesis of bronchial asthma (asthma) is ambiguous as NO may confer both protective and detrimental effects depending on the NO synthase (NOS) isoforms, tissue compartments and underlying pathological conditions (e.g. systemic inflammation). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor and uncoupler of NOS with distinct selectivity for NOS isoforms. In a cross-sectional study, we assessed whether ADMA is an independent predictor of airway resistance (Raw) in therapy-controlled asthma...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29307791/pdd-nos-psychotic-features-and-executive-function-deficits-in-a-boy-with-proximal-22q11-2-microduplication-evolution-of-the-psychiatric-symptom-profile-from-childhood-to-adolescence
#16
L Woestelandt, A Novo, A Philippe, N Guyaux, M Rio, S Romano, L Robel
22q11.2 microduplication (22q11.2DupS) is associated with a broad spectrum of phenotypes, including normality. Psychiatric disorders are described in 13% of these patients, including Attention Deficit and Hyperactivity Disorder (ADHD), Intellectual Deficiency (ID), and Autism Spectrum Disorder (ASD), but not schizophrenia. We report changes in the psychiatric symptom profile in the course of development of a young boy with a 22q11.2DupS syndrome, from early childhood to adolescence. The boy's psychiatric presentation was characterized by features of Pervasive Developmental Disorder (PDD), with ADHD in early childhood, a single psychotic episode in mid-infancy, and executive impairment in adolescence...
January 4, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29307633/voluntary-exercise-training-restores-anticontractile-effect-of-no-in-coronary-arteries-of-adult-rats-with-antenatal-early-postnatal-hypothyroidism
#17
D K Gaynullina, A A Borzykh, S I Sofronova, E K Selivanova, A A Shvetsova, A A Martyanov, I V Kuzmin, O S Tarasova
INTRODUCTION: Our recent study showed that NO-mediated anticontractile effect of endothelium is absent in coronary arteries of adult rats, which suffered from antenatal/early postnatal hypothyroidism. This study tested the hypothesis that exercise training would improve such detrimental consequences of early thyroid deficiency. DESIGN AND METHODS: Wistar dams received propylthiouracil (PTU, 7 ppm) in drinking water during gestation and two weeks postpartum; control dams received tap water...
January 4, 2018: Nitric Oxide: Biology and Chemistry
https://www.readbyqxmd.com/read/29302559/peripheral-t-cell-lymphoma-not-otherwise-specified
#18
Kunal Kishor Jha, Suresh K Gupta, Harpreet Saluja, Nuwadatta Subedi
The peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) belongs to a heterogeneous class of aggressive neoplasms. Although several morphologic subtypes of this tumor have been described, no particular genetic, immunological, or distinct clinical features define this disease. Patients can experience night sweats, fever, lymphadenopathy, weight loss, splenomegaly, and/or skin changes. Common laboratory tests reveal that patients have anemia, thrombocytosis, lymphocytosis, eosinophilia, hypergammaglobulinemia, or increased lactate dehydrogenase...
April 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29302205/endogenous-agmatine-induced-by-ischemic-preconditioning-regulates-ischemic-tolerance-following-cerebral-ischemia
#19
Jae Hwan Kim, Jae Young Kim, Jin Young Jung, Yong Woo Lee, Won Taek Lee, Seung Kon Huh, Jong Eun Lee
Ischemic preconditioning (IP) is one of the most important endogenous mechanisms that protect the cells against ischemia-reperfusion (I/R) injury. However, the exact molecular mechanisms remain unclear. In this study, we showed that changes in the level of agmatine were correlated with ischemic tolerance. Changes in brain edema, infarct volume, level of agmatine, and expression of arginine decarboxylase (ADC) and nitric oxide synthases (NOS; inducible NOS [iNOS] and neural NOS [nNOS]) were analyzed during I/R injury with or without IP in the rat brain...
December 2017: Experimental Neurobiology
https://www.readbyqxmd.com/read/29301832/pharmacological-inhibition-of-nos-activates-ask1-jnk-pathway-augmenting-docetaxel-mediated-apoptosis-in-triple-negative-breast-cancer
#20
Daniel Dávila-González, Dong Soon Choi, Roberto R Rosato, Sergio Granados-Principal, John G Kuhn, Wen-Feng Li, Wei Qian, Wen Chen, Anthony J Kozielski, Helen H Wong, Bhuvanesh Dave, Jenny C Chang
PURPOSE: Chemoresistance in triple negative breast cancer (TNBC) is associated with the activation of a survival mechanism orchestrated by the endoplasmic reticulum (EnR) stress response and by inducible nitric oxide synthase (iNOS). Our aim was to determine the effects of pharmacological NOS-inhibition on TNBC. EXPERIMENTAL DESIGN: TNBC cell lines, SUM-159PT, MDA-MB-436, and MDA-MB-468, were treated with docetaxel and NOS-inibitor (L-NMMA) for 24, 48 and 72 hours...
January 4, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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