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https://www.readbyqxmd.com/read/28225916/expression-profiles-of-enos-inos-and-microrna-27b-in-the-corpus-cavernosum-of-rats-submitted-to-chronic-alcoholism-and-diabetes-mellitus
#1
Joao Paulo da Cunha, Fermino Sanches Lizarte, Paulo Cezar Novais, Daniela Gattas, Camila Albuquerque Mello de Carvalho, Daniela Pretti da Cunha Tirapelli, Carlos Augusto Fernandes Molina, Luis Fernando Tirapelli, Silvio Tucci
Purpose: To evaluate the expression of endothelial and inducible NOS in addition to the miRNA-27b in the corpus cavernosum and peripheral blood of healthy rats, diabetic rats, alcoholic rats and rats with both pathologies. Methods: Forty eight Wistar rats were divided into four groups: control (C), alcoholic (A), diabetic (D) and alcoholic-diabetic (AD). Samples of the corpus cavernosum were prepared to study protein expressions of eNOS and iNOS by immunohistochemistry and expression of miRNA-27b in the corpus cavernosum and peripheral blood...
January 2017: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/28225908/intimate-partner-violence-reported-by-female-and-male-users-of-healthcare-units
#2
Claudia Renata Dos Santos Barros, Lilia Blima Schraiber
OBJECTIVE: To analyze nonfatal violence suffered and committed by adult men and women, in an intimate relationship. METHODS: The participants in the research were women aged between 15 and 49 years and men between 18 and 60 years, interviewed by face-to-face questionnaire application. The sample selection was of consecutive type, according to the order of arrival of the users. We conducted temporarily independent investigations and covered different health services to avoid couples and relationships in which the retaliation could be overvalued...
February 16, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28225888/local-inhibition-of-nitrergic-activity-in-tenotomized-rats-accelerates-muscle-regeneration-by-increasing-fiber-area-and-decreasing-central-core-lesions
#3
A D Seabra, S A S Moraes, E J O Batista, T B Garcia, M C Souza, K R M Oliveira, A M Herculano
Muscular atrophy is a progressive degeneration characterized by muscular proteolysis, loss of mass and decrease in fiber area. Tendon rupture induces muscular atrophy due to an intrinsic functional connection. Local inhibition of nitric oxide synthase (NOS) by Nω-nitro-L-arginine methyl ester (L-NAME) accelerates tendon histological recovery and induces functional improvement. Here we evaluate the effects of such local nitrergic inhibition on the pattern of soleus muscle regeneration after tenotomy. Adult male Wistar rats (240 to 280 g) were divided into four experimental groups: control (n=4), tenotomized (n=6), vehicle (n=6), and L-NAME (n=6)...
February 20, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28223872/chitosan-treatment-abrogates-hypercholesterolemia-induced-erythrocyte-s-arginase-activation
#4
Gamaleldin I Harisa, Sabry M Attia, Khairy M A Zoheir, Fars K Alanazi
This study aimed to evaluate the protective effect of chitosan (CS) against hypercholesterolemia (HC) induced arginase activation and disruption of nitric oxide (NO) biosynthesis using erythrocytes as cellular model. Human erythrocytes were isolated and classified into eight groups. Next, cells were treated with l-arginine (l-ARG), N(ω)-nitro-l-arginine methyl ester (l-NAME), CS or CS + l-ARG in the presence of normal plasma or cholesterol enriches plasma. Then, erythrocytes were incubated at 37 °C for 24 h...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28222936/36-cases-adenoid-cystic-carcinoma-of-the-breast-in-china-comparison-with-matched-grade-one-invasive-ductal-carcinoma-not-otherwise-specified
#5
Shuling Wang, Weidong Li, Fang Wang, Yun Niu, Chunfang Hao, Xu Wang, Lihong He, Zhongsheng Tong
OBJECTIVE: The aim of this study was to investigate the clinicopathological characteristic of adenoid cystic carcinoma (ACC). MATERIALS AND METHODS: The clininopathological features, along with relapse free survival(RFS) and overall survival(OS) of 36 patients with ACC were retrospectively investigated and compared with those of 108 grade 1 invasive ductal carcinoma not-otherwise-specified (G1-IDC-NOS) patients. RESULTS: Most cases of ACC were ER, PR and HER-2 negative which was classified as triple-negative subtype...
January 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28222675/identification-and-characterization-of-an-efficient-acyl-coa-diacylglycerol-acyltransferase-1-dgat1-gene-from-the-microalga-chlorella-ellipsoidea
#6
Xuejie Guo, Chengming Fan, Yuhong Chen, Jingqiao Wang, Weibo Yin, Richard R C Wang, Zanmin Hu
BACKGROUND: Oil in the form of triacylglycerols (TAGs) is quantitatively the most important storage form of energy for eukaryotic cells. Diacylglycerol acyltransferase (DGAT) is considered the rate-limiting enzyme for TAG accumulation. Chlorella, a unicellular eukaryotic green alga, has attracted much attention as a potential feedstock for renewable energy production. However, the function of DGAT1 in Chlorella has not been reported. RESULTS: A full-length cDNA encoding a putative diacylglycerol acyltransferase 1 (DGAT1, EC 2...
February 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/28220904/recent-advances-in-occupational-and-environmental-health-hazards-of-workers-exposed-to-gasoline-compounds
#7
REVIEW
Christopher E Ekpenyong, Asuquo E Asuquo
The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28216514/diallyl-trisulfide-augments-ischemia-induced-angiogenesis-via-an-endothelial-nitric-oxide-synthase-dependent-mechanism
#8
Ryo Hayashida, Kazuhisa Kondo, Sumio Morita, Kazumasa Unno, Satoshi Shintani, Yuuki Shimizu, John W Calvert, Rei Shibata, Toyoaki Murohara
BACKGROUND: Hydrogen sulfide (H2S) exerts beneficial actions against the development of cardiovascular disease. Diallyl trisulfide (DATS) is an organic polysulfide found in garlic oil that liberates H2S under physiological conditions. This study investigated whether DATS modulates endothelial cell function, as well as revascularization processes in a mouse model of hind-limb ischemia.Methods and Results:Wild-type (WT), endothelial nitric oxide synthase-deficient (eNOS-KO) and Akt1-heterogenic deficient (Akt-Het) mice were subjected to unilateral hindlimb ischemia (HLI)...
February 17, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28216392/nitrergic-cardiovascular-regulation-in-the-african-lungfish-protopterus-aethiopicus
#9
Renato Filogonio, William Joyce, Tobias Wang
As a ubiquitous signaling molecule, nitric oxide (NO) exerts various important effects on the cardiovascular system and is involved in the regulation of vascular tone and myocardial metabolism in vertebrates. Lungfishes are closely related to tetrapods and provide an interesting possibility to understand the transition from water to land. Lungfishes are endowed with both systemic and pulmonary circulations, and their incompletely divided ventricle allows for blood to bypass either circuit. Lungfishes inhabit ephemeral waterbodies that may enforce prolonged aestivation during drought, throughout which nitric oxide synthase (NOS) expression is upregulated...
February 16, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28214609/evaluation-of-vascular-tone-and-cardiac-contractility-in-response-to-silver-nanoparticles-using-langendorff-rat-heart-preparation
#10
Ramirez-Lee Manuel Alejandro, Martinez-Cuevas Pedro Pablo, Rosas-Hernandez Hector, Oros-Ovalle Cuauhtémoc, Bravo-Sanchez Mariela, Martinez-Castañon Gabriel Alejandro, Gonzalez Carmen
Silver nanoparticles (AgNPs) have been widely used because of their antimicrobial properties. However, several reports suggest that AgNPs exposure promote cardiac effects that involve nitric oxide (NO) and oxidative stress (OS). Nevertheless, there are no studies related to AgNPs-induced effects in cardiac physiology. The aim of this study was to evaluate the AgNPs direct actions on coronary vascular tone and cardiac contractility using Langendorff rat heart preparation. Low concentrations of AgNPs (0.1 and 1μg/mL) increased NO derived from inducible NO-synthase (iNOS), without modifying cardiac parameters...
February 15, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28214203/prognostic-value-of-survivin-and-dna-topoisomerase-ii%C3%AE-in-diffuse-and-anaplastic-astrocytomas
#11
R K Varughese, A J Skjulsvik, S H Torp
Distinguishing WHO grade II astrocytomas from grade III is a difficult task. This study looks into the potential prognostic use of mitotic activity and the proliferation markers Ki67/MiB-1 (Ki67), survivin and DNA topoisomerase IIα (TIIα) in 59 WHO grade II diffuse astrocytomas (DA) and 33 WHO grade III anaplastic astrocytomas (AA), IDH1 R132H-mutated and not otherwise specified (NOS) by means of immunohistochemistry. All proliferation markers showed higher expression in AA compared with DA. Only Ki67 had significantly greater expression in astrocytomas, NOS vs...
January 21, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28213332/shear-stress-enhances-ca-2-sparks-through-nox2-dependent-mitochondrial-reactive-oxygen-species-generation-in-rat-ventricular-myocytes
#12
Joon-Chul Kim, Jun Wang, Min-Jeong Son, Sun-Hee Woo
Shear stress enhances diastolic and systolic Ca(2+) concentration in ventricular myocytes. Here, using confocal Ca(2+) imaging in rat ventricular myocytes, we assessed the effects of shear stress (~16dyn/cm(2)) on the frequency of spontaneous Ca(2+) sparks and explored the mechanism underlying shear-mediated Ca(2+) spark regulation. The frequency of Ca(2+) sparks was immediately increased by shear stress (by ~80%), and increased further (by ~150%) during prolonged exposure (20s). The 2-D size and duration of individual sparks were increased by shear stimulation...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28210905/hypermagnesemia-disturbances-in-rats-no-related-pentadecapeptide-bpc-157-abrogates-l-name-and-l-arginine-worsen
#13
Maria Medvidovic-Grubisic, Vasilije Stambolija, Danijela Kolenc, Jadranka Katancic, Tamara Murselovic, Ivna Plestina-Borjan, Sanja Strbe, Domagoj Drmic, Ivan Barisic, Aleksandra Sindic, Sven Seiwerth, Predrag Sikiric
AIM: Stable gastric pentadecapeptide BPC 157, administered before a high-dose magnesium injection in rats, might be a useful peptide therapy against magnesium toxicity and the magnesium-induced effect on cell depolarization. Moreover, this might be an NO-system-related effect. Previously, BPC 157 counteracts paralysis, arrhythmias and hyperkalaemia, extreme muscle weakness; parasympathetic and neuromuscular blockade; injured muscle healing and interacts with the NOS-blocker and NOS-substrate effects...
February 16, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28209473/analysis-of-peripheral-t-cell-lymphoma-diagnostic-workup-in-the-united-states
#14
Eric D Hsi, Steven M Horwitz, Kenneth R Carson, Lauren C Pinter-Brown, Steven T Rosen, Barbara Pro, Massimo Federico, Christian Gisselbrecht, Marc Schwartz, Lisa A Bellm, Mark Acosta, Angela M Collie, Aaron M Gruver, Bartosz J Grzywacz, Samir Turakhia, Andrei R Shustov, Ranjana H Advani, Tatyana Feldman, Mary Jo Lechowicz, Sonali M Smith, Frederick Lansigan, Anil Tulpule, Michael D Craig, John P Greer, Brad S Kahl, Joseph W Leach, Neil Morganstein, Carla Casulo, Steven I Park, Francine M Foss
BACKGROUND: With increased understanding of the unique entities, subtype-specific approaches for peripheral T-cell lymphoma (PTCL) are emerging, and more precise diagnoses are becoming increasingly important. PATIENTS AND METHODS: We analyzed the approach to the histopathologic diagnosis of PTCL using data from the comprehensive oncology measures of peripheral T-cell lymphoma (COMPLETE) study. The COMPLETE trial is a large prospective cohort study of patients with newly diagnosed PTCL in the United States...
January 10, 2017: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/28206965/prognostic-role-of-platelet-to-lymphocyte-ratio-in-hepatocellular-carcinoma-a-systematic-review-and-meta-analysis
#15
Yongzhao Zhao, Guangyan Si, Fengshang Zhu, Jialiang Hui, Shangli Cai, Chenshen Huang, Sijin Cheng, Abdel Hamid Fathy, Yi Xiang, Jing Li
BACKGROUND AND AIMS: Several studies were conducted to explore the prognostic significance of platelet to lymphocyte ratio (PLR) in hepatocellular carcinoma (HCC), however, contradictory results across most reports were documented. To this end, we present a systematic review that aims to summarize the prognostic significance of PLR in patients with HCC. RESULTS: A total of 10 studies involving a total of 2,315 patients were identified. The Newcastle-Ottawa Quality Assessment Scale (NOS) of each included study was greater than or equal to 5...
February 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28198968/effects-of-dignity-therapy-on-terminally-ill-patients-a-systematic-review
#16
Suzana Cristina Teixeira Donato, Jéssica Yumi Matuoka, Camila Cristófero Yamashita, Marina de Goés Salvetti
OBJECTIVE: Analyzing the evidence of the effects of dignity therapy onterminally ill patients. METHOD: A Systematic review of the literature conducted using the search strategy in six databases. Inclusion criteria were primary studies, excluding literature reviews (systematic or not) and conceptual articles. RESULTS: Ten articles were analyzed regarding method, results and evidence level. Dignity therapy improved the sense of meaning andpurpose, will to live, utility, quality of life, dignity and family appreciationin studies with a higher level of evidence...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198967/fall-and-its-association-with-the-frailty-syndrome-in-the-elderly-systematic-review-with-meta-analysis
#17
Jack Roberto Silva Fhon, Rosalina Aparecida Partezani Rodrigues, Wilmer Fuentes Neira, Violeta Magdalena Rojas Huayta, Maria Lucia do Carmo Cruz Robazzi
OBJECTIVE: To analyze the prevalence of falls and frailty syndrome and the association between these two syndromes in the elderly population. METHOD: Systematic review, without restriction of dates, in English, Portuguese and Spanish languages, in the databases PubMed, CINAHL, LILACS and in the SciElo virtual library. The association between both variables was extracted from the studies (Odds Ratio and 95% Confidence Intervals). RESULTS: The review included 19 studies published between 2001 and 2015...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198962/myocardial-revascularization-factors-intervening-in-the-reference-and-counter-reference-in-primary-health-care
#18
Kamylla Santos da Cunha, Giovana Dorneles Callegaro Higashi, Alacoque Lorenzini Erdmann, Carolina Kahl, Cintia Koerich, Betina Hörner Schlindwein Meirelles
OBJECTIVE: Understanding the factors that influence the reference and counter-reference process of people indicated/submitted to Myocardial Revascularization surgery in the Primary Health Care scenario. METHOD: A qualitative research anchored in the Grounded Theory, totaling 41 participants subdivided into three groups (patients, health professionals and managers) in the Metropolitan and West Region of Santa Catarina. RESULTS: Two categories elucidate the intervening factors found, contrasting the potentialities and obstacles in (creating) the bond between people affected by cardiovascular diseases and primary health care for the reference process, highlighting weaknesses in the primary health care services provided, with failures in the counter-reference for people submitted to myocardial revascularization surgery...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198960/quality-of-life-of-patients-with-graft-versus-host-disease-gvhd-post-hematopoietic-stem-cell-transplantation
#19
Sibéli de Fátima Ferraz Simão Proença, Celina Mattos Machado, Raquel de Castro Figueiredo Pereira Coelho, Leila Maria Mansano Sarquis, Paulo Ricardo Bittencourt Guimarães, Luciana Puchalski Kalinke
OBJECTIVE: Assessing the quality of life of adult patients with hematological cancer in the 100 days after transplantation of hematopoietic stem cells and verifying whether the variable graft-versus-host disease (GvHD) is predictive of worse results. METHOD: An observational correlational and quantitative study with 36 adult participants diagnosed with hematologic cancer who underwent hematopoietic stem cell transplantation from September 2013 to June 2015. RESULT: The mean age was 37 years, 52...
November 2016: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/28198955/-un-receptiveness-in-interactions-with-professionals-experiences-of-parents-of-children-with-retinopathy-of-prematurity
#20
Beatriz Castanheira Facio, Bruna de Souza Lima Marski, Ieda Harumi Higarashi, Maira Deguer Misko, Aline Oliveira Silveira, Monika Wernet
OBJECTIVE: To analyze the influence of health professionals' receptiveness on parental care of children with retinopathy of prematurity (ROP). METHOD: A qualitative study developed under the theoretical framework of Symbolic Interactionism and using a narrative research methodology. Six women and three men, being parents of children with retinopathy of prematurity were individually interviewed in depth. RESULTS: From the scope of information, emotions and their rights, the parents experienced receptiveness from some professionals and unreceptiveness from others...
November 2016: Revista da Escola de Enfermagem da U S P
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