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https://www.readbyqxmd.com/read/29138938/jasmonic-acid-induced-no-activates-mek1-2-in-regulating-the-metabolism-of-ascorbate-and-glutathione-in-maize-leaves
#1
Changjuan Shan, Haili Sun
This study investigated the relationship between MEK1/2 and nitric oxide (NO) in jasmonic acid (JA)-regulated metabolism of ascorbate and glutathione in maize leaves. The results showed that JA increased the activities of APX, GR, MDHAR, DHAR, GalLDH, and γ-ECS; the contents of AsA and GSH; and the production of NO. Above increases except for γ-ECS activity and NO production were all suppressed by pre-treatments with MEK1/2 inhibitors PD98059 and U0126. Above increases were all suppressed by pre-treatments with nitric oxide synthase (NOS) inhibitor L-NAME and NO scavenger cPTIO...
November 14, 2017: Protoplasma
https://www.readbyqxmd.com/read/29138357/tadalafil-a-long-acting-phosphodiesterase-inhibitor-promotes-bone-marrow-stem-cell-survival-and-their-homing-into-ischemic-myocardium-for-cardiac-repair
#2
Ibrahim Elmadbouh, Muhammad Ashraf
The aim was to evaluate the tadalafil-mediated effects at molecular level on bone marrow-derived mesenchymal stem cells (MSCs) survival and their homing into the infarcted hearts to promote cardiac repair and improve function. MSCs were pretreated in vitro with inhibitors of PKG, MAPK, FasL, nitric oxide synthase (NOS) (L-NAME), CXCR4 (AMD3100), or miR-21 inhibitors (+/-luciferase construction +/-Fas) prior to tadalafil treatment for 2 h. These MSCs were then subjected to H2O2 stress to assess their injury...
November 2017: Physiological Reports
https://www.readbyqxmd.com/read/29137683/tanshinone-i-alleviates-motor-and-cognitive-impairments-via-suppressing-oxidative-stress-in-the-neonatal-rats-after-hypoxic-ischemic-brain-damage
#3
Chunfang Dai, Yannan Liu, Zhifang Dong
Neonatal hypoxia-ischemia is one of the main reasons that cause neuronal damage and neonatal death. Several studies have shown that tanshinone I (TsI), one of the major ingredients of Danshen, exerts potential neuroprotective effect in adult mice exposed to permanent left cerebral ischemia. However, it is unclear whether administration of TsI has neuroprotective effect on neonatal hypoxic-ischemic brain damage (HIBD), and if so, the potential mechanisms also remain unclear. Here, we reported that treatment with TsI (5 mg/kg, i...
November 14, 2017: Molecular Brain
https://www.readbyqxmd.com/read/29136575/the-correlation-between-concentrations-of-zolpidem-and-benzodiazepines-in-segmental-hair-samples-and-use-patterns
#4
Hyojeong Kim, Sangeun Lee, Sanghwan In, Meejung Park, Sungnam Cho, Junguk Shin, Hunjoo Lee, Eunyoung Han
The aim of this study was to investigate the correlation between histories of zolpidem and benzodiazepines use and their concentrations in hair as determined by segmental hair analysis, that is, by analyzing hair samples taken 0-1, 1-2, 2-3, 3-4, 4-5, and 5-6cm etc. and 0-3cm from the scalp, and whole hair. Of the 23 hair samples examined, 18 were collected from patients in a rehabilitation program and five were from patients that had taken zolpidem only once by prescription. All 23 patients provided written informed consent after reviewing the research plan, described their zolpidem and benzodiazepines use histories accurately, and provided hair samples, which were weighed, washed, cut into lengths of <1mm, and extracted in 100% methanol for 16h (diazepam-d5 was used as an internal standard)...
November 7, 2017: Forensic Science International
https://www.readbyqxmd.com/read/29136143/time-varying-cycle-average-and-daily-variation-in-ambient-air-pollution-and-fecundability
#5
Carrie J Nobles, Enrique F Schisterman, Sandie Ha, Germaine M Buck Louis, Seth Sherman, Pauline Mendola
STUDY QUESTION: Does ambient air pollution affect fecundability? SUMMARY ANSWER: While cycle-average air pollution exposure was not associated with fecundability, we observed some associations for acute exposure around ovulation and implantation with fecundability. WHAT IS KNOWN ALREADY: Ambient air pollution exposure has been associated with adverse pregnancy outcomes and decrements in semen quality. STUDY DESIGN, SIZE, DURATION: The LIFE study (2005-2009), a prospective time-to-pregnancy study, enrolled 501 couples who were followed for up to one year of attempting pregnancy...
November 10, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29135983/arginase-expression-modulates-nitric-oxide-production-in-leishmania-leishmania-amazonensis
#6
Stephanie Maia Acuña, Juliana Ide Aoki, Maria Fernanda Laranjeira-Silva, Ricardo Andrade Zampieri, Juliane Cristina Ribeiro Fernandes, Sandra Marcia Muxel, Lucile Maria Floeter-Winter
BACKGROUND: Arginase is an enzyme that converts L-arginine to urea and L-ornithine, an essential substrate for the polyamine pathway supporting Leishmania (Leishmania) amazonensis replication and its survival in the mammalian host. L-arginine is also the substrate of macrophage nitric oxide synthase 2 (NOS2) to produce nitric oxide (NO) that kills the parasite. This competition can define the fate of Leishmania infection. METHODOLOGY/PRINCIPAL FINDINGS: The transcriptomic profiling identified a family of oxidoreductases in L...
2017: PloS One
https://www.readbyqxmd.com/read/29132129/administration-of-curcumin-protects-kidney-tubules-against-renal-ischemia-reperfusion-injury-riri-by-modulating-nitric-oxide-no-signaling-pathway
#7
Fuhe Liu, Wenjuan Ni, Jiajia Zhang, Guokang Wang, Fanzhu Li, Wenxia Ren
BACKGROUND/AIMS: To explore the protective effect of curcumin on renal ischemia-reperfusion injury (RIRI) in rats, and its influence on nephridial tissue's NO and cGMP levels as well as downstream signaling pathway, to elucidate the possible mechanism of curcumin on RIRI. METHODS: 36 Sprague Dawley rats (SD rats) were randomly divided into Sham group, Model group, curcumin (CUR +) Model group, 12 rats per group. They were all given RIRI model preparation by unilateral artery occlusion method...
November 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130129/impact-of-on-site-sanitation-systems-on-groundwater-sources-in-a-coastal-aquifer-in-chennai-india
#8
Chandrakant Jangam, Paras Pujari
On-site sanitation is the most preferred mode of sanitation due to expensive off-site sanitation. The increasing population especially in the peri-urban areas has led to increasing use of on-site sanitation systems in India. However, the habitations in the vicinity of these systems do not have centralised water supply and are dependent on groundwater sources. However, there is concern about leaching of faecal coliforms and nitrate from the septic tanks to the underlying aquifer. The present study is attempted at two sites in the coastal city of Chennai where on-site sanitation is prevailing...
November 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29128547/associations-between-asymmetric-dimethylarginine-adma-nitrite-dependent-renal-carbonic-anhydrase-activity-and-plasma-testosterone-levels-in-hypogonadal-men
#9
Dimitrios Tsikas, Manfred Kinzel
BACKGROUND: Circulating inorganic nitrite (NO2(-)) is an abundant nitric oxide (NO) reservoir. Renal carbonic anhydrase (CA) mediates the absorption of urinary nitrite. The urinary nitrate-to-nitrite molar ratio UNOxR is a measure of nitrite-dependent renal CA activity. The CA family is also involved in the bioactivation of nitrite to S-nitrosothiols and NO. Thus, CA isoforms may combat atherosclerosis. METHODS: In plasma and urine of ten hypogonadal men we measured the major NO metabolites nitrite and nitrate, and the endogenous inhibitor of NO synthase (NOS) asymmetric dimethylarginine (ADMA) before and after a 24-weeks testosterone treatment to normalize plasma testosterone levels...
November 8, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29127889/nitric-oxide-and-arginase-levels-in-peri-implant-tissues-after-delayed-loading
#10
Ceren Gokmenoglu, Nurdan Ozmeric, Caglar Sungur, Raziye Sahin Bildik, Imge Erguder, Serenay Elgun
OBJECTIVE: Nitric oxide (NO) is synthesized from the conversion of L-arginine to L-citrulline by NO synthase (NOS). Arginase can compete with NOS for the common substrate L-arginine, and thus inhibit NO production. NO levels and arginase ezyme might affect the bone remodeling cycle around implants. The aim of this studywas to investigate NO and arginase levels in gingival crevicular fluid (GCF), peri-implant sulcular fluid (PISF), and saliva. MATERIALS AND METHODS: Twenty patients with one or more implants (Straumann(®); Institute Straumann AG, Basel, Switzerland) restored with fixed crown prostheses were included in the study...
October 23, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29126791/the-cardioprotective-effects-of-epicatechin-are-mediated-through-arginase-activity-inhibition-in-a-murine-model-of-ischemia-reperfusion
#11
Pilar Ortiz-Vilchis, Miguel Ortiz-Flores, Marcela Pacheco, Israel Ramirez-Sanchez, Aldo Moreno-Ulloa, Lourdes Vega, Alicia Ortiz, Francisco Villarreal, Ivan Rubio-Gayosso, Nayelli Najera, Eduardo Meaney, Guillermo Ceballos
The production of nitric oxide (NO) by nitric oxide synthases (NOS) depends on the bioavailability of L-arginine as NOS competes with arginase for this common substrate. As arginase activity increases, less NO is produced and adverse cardiovascular consequences can emerge. (-)-Epicatechin (EPI), the most abundant flavonoid in cacao, has been reported to stimulate endothelial and neuronal NOS expression and function leading to enhanced vascular function and cardioprotective effects. However, little is known about the effects of EPI on myocardial arginase activity...
November 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29125838/nitrergic-neurons-of-the-dorsal-raphe-nucleus-encode-information-about-stress-duration
#12
India S Nichols, Mary I Jones, Chuma Okere, Godwin Ananaba, Brittany Bush, Cloe Gray, Allison Brager, J Christopher Ehlen, Ketema Paul
Nitrergic neurons of the dorsal raphe nucleus (DRN) may play a role in physiological stress responses. The caudal lateral wings (CLW) are unique compared to other rostral-caudal DRN sub-regions because they contain distinct nitric oxide (NO) synthase (NOS) populations that are independent of tryptophan hydroxylase (TPH). NOS neurons in the CLW are also highly activated during acute restraint stress. However, the effects of acute stress duration on NOS activation in the CLW are unclear. Here NADPH-d, an index of NOS activity, is used to show that sub-regions of the DRN have differential NOS activation in response to 6 hours of restraint stress in rats...
2017: PloS One
https://www.readbyqxmd.com/read/29125664/changes-of-nitric-oxide-levels-and-its-relationship-with-callose-deposition-during-the-interaction-between-soybean-and-soybean-mosaic-virus
#13
Dongqiang Xiao, Xixi Duan, Mengshu Zhang, Tianjie Sun, Xizhe Sun, Fukuan Li, Na Liu, Jie Zhang, Chunyan Hou, Dongmei Wang
The present study was aimed to investigate the changes of Nitric Oxide (NO) levels and its relationship with callose deposition during the interaction between soybean and Soybean mosaic virus(SMV). The soybean cv. 'Jidou 7' and the SMV strains N3 and SC-8 were used to constitute incompatible and compatible combinations. Intracellular NO was labeled with the NO-specific fluorescent probe DAF-FM DA. Confocal laser scanning microscope (CLSM) was then used to observe the changes in NO production during SMV infection-induced defense responses in soybean...
November 10, 2017: Plant Biology
https://www.readbyqxmd.com/read/29125387/significado-de-psic%C3%A3-logas-os-de-atenci%C3%A3-n-primaria-de-salud-sobre-la-intervenci%C3%A3-n-psicosocial-de-grupo-en-el-tratamiento-de-la-depresi%C3%A3-n-en-chile
#14
Gonzalo Andrade, Adriana Espinoza
En Chile, el tratamiento de la depresión en salud pública promueve la realización de Intervenciones Psicosociales en Grupo (IPG) para todos los casos diagnosticados, no obstante, se observa una baja implementación de estas prestaciones. El presente artículo describe y caracteriza, desde el punto de vista de la disciplina psicológica, el significado de psicólogas/os que trabajan en consultorios de atención primaria de salud (APS) sobre las IPG en el tratamiento de la depresión. Se entrevistaron a ocho psicólogas/os de los distintos Servicios de Salud de la Región Metropolitana de Santiago...
November 1, 2017: Global Health Promotion
https://www.readbyqxmd.com/read/29124687/ultraviolet-light-induced-generation-of-reactive-oxygen-species
#15
T L de Jager, A E Cockrell, S S Du Plessis
As ultraviolet (UV) radiation is naturally and ubiquitously emitted by the sun, almost everyone is exposed to it on a daily basis, and it is necessary for normal physiological function. Human exposure to solar UV radiation thus has important health implications. The generation of reactive oxygen species (ROS) by UV radiation is one of the mechanisms through which UV light can manifest its possible detrimental effects on health. When an imbalance develops due to ROS generation exceeding the body's antioxidant defence mechanisms, oxidative stress can develop...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29121802/hispolon-suppresses-lps-or-lta-induced-inos-no-production-and-apoptosis-in-bv-2-microglial-cells
#16
Ming-Shun Wu, Chih-Chiang Chien, Kur-Ta Cheng, Gottumukkala V Subbaraju, Yen-Chou Chen
Hispolon (HIS) is an active polyphenol compound derived from Phellinus linteus (Berkeley & Curtis), and our previous study showed that HIS effectively inhibited inflammatory responses in macrophages (Yang et al., 2014); however, its effect on neuronal inflammation is still undefined. In this study, HIS concentration- and time-dependently inhibited lipopolysaccharide (LPS)- and lipoteichoic acid (LTA)-induced inducible nitric oxide (NO) synthase (iNOS)/NO production with increased heme oxygenase (HO)-1 proteins in BV-2 microglial cells...
November 9, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29121774/sphingolipids-and-redox-signaling-in-renal-regulation-and-chronic-kidney-diseases
#17
Owais M Bhat, Xinxu Yuan, Guangbi Li, RaMi Lee, Pin Lan Li
SIGNIFICANCE: Sphingolipids play critical roles in the membrane biology and intracellular signaling events that influence cellular behavior and function. Our review focuses on the cellular mechanisms and functional relevance of the cross talk between sphingolipids and redox signaling, which may be critically implicated in the pathogenesis of different renal diseases. Recent Advances: Reactive oxygen species (ROS) and sphingolipids can regulate cellular redox homeostasis through the regulation of NADPH oxidase, mitochondrial integrity, nitric oxide synthase (NOS) and antioxidant enzymes...
November 9, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29120387/alteration-of-vascular-responsiveness-to-uridine-adenosine-tetraphosphate-in-aortas-isolated-from-male-diabetic-otsuka-long-evans-tokushima-fatty-rats-the-involvement-of-prostanoids
#18
Takayuki Matsumoto, Shota Kobayashi, Makoto Ando, Maika Iguchi, Keisuke Takayanagi, Mihoka Kojima, Kumiko Taguchi, Tsuneo Kobayashi
We investigated whether responsiveness to dinucleotide uridine adenosine tetraphosphate (Up₄A) was altered in aortas from type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats compared with those from age-matched control Long-Evans Tokushima Otsuka (LETO) rats at the chronic stage of disease. In OLETF aortas, we observed the following: (1) Up₄A-induced contractions were lower than those in the LETO aortas under basal conditions, (2) slight relaxation occurred due to Up₄A, but this was not observed in phenylephrine-precontracted LETO aortas, (3) acetylcholine-induced relaxation was reduced (vs...
November 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29120321/une-sant%C3%A3-mondiale-repens%C3%A3-e-la-perspective-de-futures-chercheuses-praticiennes
#19
Muriel Mac-Seing, Cielo Perez Osorio, Stella Tine, Charity Oga Omenka, Rolande Chegno Gueutue
 L'étude des conséquences de la mondialisation sur la santé des populations est au coeur de la santé mondiale. Ce faisant, la mondialisation conditionne également la mise en oeuvre des projets de recherche et des interventions en santé mondiale, et les rapports sociaux inégalitaires qui s'y perpétuent. Le présent commentaire propose des réflexions sur des défis épistémologiques et politiques auxquels se confronte la santé mondiale. Celles-ci sont issues d'observations et de discussions pendant et après la Conférence canadienne sur la santé mondiale, tenue en novembre 2015...
November 9, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/29119842/outcomes-following-front-line-chemotherapy-in-peripheral-t-cell-lymphoma-10-year-experience-at-the-royal-marsden-and-the-christie-hospital
#20
Mary Gleeson, Clare Peckitt, David Cunningham, Adam Gibb, Eliza A Hawkes, Morgan Back, Binnaz Yasar, Kate Foley, Rebecca Lee, Joanna Dash, Hannah Johnson, Catherine O'Hara, Andrew Wotherspoon, Ayoma Attygalle, Lia Menasce, Patrick Shenjere, Mike Potter, Mark E Ethell, Claire Dearden, John Radford, Ian Chau, Kim Linton
We evaluated the outcomes for patients with peripheral T-cell lymphoma (PTCL) undergoing front-line chemotherapy at our institutions between 2002 and 2012. One hundred and fifty-six patients were eligible, comprising PTCL not otherwise specified (NOS) (n = 50, 32.0%), angioimmunoblastic T-cell lymphoma (AITL) (n = 44, 28.2%), anaplastic large-cell lymphoma (ALCL) ALK negative (n = 23, 14.7%), ALCL ALK positive (n = 16, 10.3%), and other (n = 23, 14.7%). Most patients received CHOP (66.0%) and 13...
November 9, 2017: Leukemia & Lymphoma
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