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https://www.readbyqxmd.com/read/28323933/research-resource-transcriptional-dynamics-of-cultured-human-villous-cytotrophoblasts
#1
Joshua F Robinson, Mirhan Kapidzic, Matthew Gormley, Katherine Ona, Terrence Dent, Helia Seifikar, Emily G Hamilton, Susan J Fisher
During human pregnancy, cytotrophoblasts (CTBs) play key roles in uterine invasion, vascular remodeling, and anchoring of the feto-placental unit. Due to the challenges associated with studying human placentation in utero, cultured primary villous CTBs are used as a model of the differentiation pathway that leads to invasion of the uterine wall. In vitro, CTBs emulate in vivo cell behaviors, such as migration, aggregation and substrate penetration. While some of the molecular features related to these cell behaviors have been described, the underlying mechanisms, at a global level, remain undefined at mid-gestation...
March 8, 2017: Endocrinology
https://www.readbyqxmd.com/read/28289056/expression-and-trafficking-of-placental-micrornas-at-the-feto-maternal-interface
#2
Guojing Chang, Jean-François Mouillet, Takuya Mishima, Tianjiao Chu, Elena Sadovsky, Carolyn B Coyne, W Tony Parks, Urvashi Surti, Yoel Sadovsky
During pregnancy, placental trophoblasts at the feto-maternal interface produce a broad repertoire of microRNA (miRNA) species. These species include miRNA from the primate-specific chromosome 19 miRNA cluster (C19MC), which is expressed nearly exclusively in the placenta. Trafficking of these miRNAs among the maternal, placental, and fetal compartments is unknown. To determine miRNA expression and trafficking patterns during pregnancy, we sequenced miRNAs in triads of human placenta and of maternal and fetal blood and found large subject-to-subject variability, with C19MC exhibiting compartment-specific expression...
March 13, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28270873/predictors-of-fetal-and-maternal-outcome-in-the-crucible-of-hepatic-dysfunction-during-pregnancy
#3
Indrajit Suresh, Vijaykumar Tr, Nandeesh Hp
BACKGROUND: Hepatic dysfunction during pregnancy places both the mother and the fetus at risk. Investigations which are efficient, cost effective and easily available for prognostication are required to tackle this global problem. We studied the etiologies and evaluated investigations for predictive efficiency. METHODS: One hundred ninety-seven pregnant women with hepatic dysfunction during pregnancy were identified. All patients were followed up till 8 weeks after termination of pregnancy or death...
February 2017: Gastroenterology Research
https://www.readbyqxmd.com/read/28267443/balloon-removal-after-fetoscopic-endoluminal-tracheal-occlusion-for-congenital-diaphragmatic-hernia
#4
Julio A Jiménez, Elisenda Eixarch, Philip Dekoninck, João R Bennini, Roland Devlieger, Cleisson F Peralta, Eduard Gratacos, Jan Deprest
BACKGROUND: Isolated congenital diaphragmatic hernia (CDH) defect allows viscera to herniate into the chest, competing for space with the developing lungs. At birth, pulmonary hypoplasia leads to respiratory insufficiency and persistent pulmonary hypertension that is lethal in up to 30% of patients. Antenatal measurement of lung size and liver herniation can predict survival after birth. Prenatal intervention aims at stimulating lung development, clinically achieved by percutaneous fetal endoscopic tracheal occlusion (FETO) under local anesthesia...
March 3, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28262230/placental-hemostasis-and-sterile-inflammation-new-insights-into-gestational-vascular-disease
#5
Shrey Kohli, Berend Isermann
Activation of the coagulation and inflammatory systems are physiologically occurring during pregnancy. However, excess activation of either system is well documented in gestational vascular diseases (GVD). GVD are placenta-mediated pregnancy complications and a major cause of feto-maternal morbidity and mortality. The causal relevance of excess coagulation and inflammatory responses for GVD remains largely unknown. Deciphering the causal relationship of excess coagulation and inflammation in GVD may allow conceptualizing new therapeutic approaches to combat GVD...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28258413/viscosity-and-haemodynamics-in-a-late-gestation-rat-feto-placental-arterial-network
#6
Nikhilesh Bappoo, Lachlan J Kelsey, Louis Parker, Tim Crough, Carmel M Moran, Adrian Thomson, Megan C Holmes, Caitlin S Wyrwoll, Barry J Doyle
The placenta is a transient organ which develops during pregnancy to provide haemotrophic support for healthy fetal growth and development. Fundamental to its function is the healthy development of vascular trees in the feto-placental arterial network. Despite the strong association of haemodynamics with vascular remodelling mechanisms, there is a lack of computational haemodynamic data that may improve our understanding of feto-placental physiology. The aim of this work was to create a comprehensive 3D computational fluid dynamics model of a substructure of the rat feto-placental arterial network and investigate the influence of viscosity on wall shear stress (WSS)...
March 3, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28240019/differential-expression-of-glypican-3-and-insulin%C3%A2-like-growth-factor-ii-mrnas-and-alpha-fetoprotein-and-ki-67-markers-in-hcv-related-hepatocellular-carcinomas-in-egyptian-patients
#7
Mohamed A Saber, Samah MM AbdelHafiz, Fatma E Khorshed, Tarek S Aboushousha, Hussam EM Hamdy, Mohamed I Seleem, Amira H Soliman
Background: Increasing evidence indicates that in hepatocellular carcinomas (HCCs) abnormal gene expression, for example of glypican-3 (GPC-3) and insulin-like growth factor-II (IGF-II), are associated with the occurrence and progression of HCC. The objective of this study was to evaluate the differential expression of GPC-3 and IGF-II mRNAs in HCC tissues with a background of chronic hepatitis C virus (HCV) genotype 4 cirrhosis, in relation to Ki-67 and alpha-feto protein (AFP) tissue markers. Methods: One hundred and five patients with HCCs who had undergone hepatectomy, were included, after obtaining informed consent...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28238383/placental-findings-in-feto-maternal-hemorrhage-in-livebirth-and-stillbirth
#8
Sanjita Ravishankar, Alison Migliori, Judy Struminsky, Phinnara Has, C James Sung, Mai He
Feto-maternal hemorrhage (FMH) is not an uncommon event during pregnancy with important clinical implications for both maternal and fetal outcomes. The diagnosis is often made using Kleihauer-Betke (KB) test. As FMH occurs transplacentally, examination of the placenta may contribute to the diagnosis of FMH. This retrospective case-control study aims to examine the placental features associated FMH in patients with known positive KB test results. When compared with KB negative placentas (n=88), KB positive placentas (n=49) had significantly higher incidence of pallor (6/49 vs 0/88, p=0...
February 6, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28236844/altered-metabolic-homeostasis-between-vitamin-d-and-long-chain-polyunsaturated-fatty-acids-in-preeclampsia
#9
Anindita A Nandi, Nisha S Wadhwani, Sadhana R Joshi
Sub-optimal maternal nutrition may result in pregnancy complications like preeclampsia. Preeclampsia is known to be of placental origin and a major cause of maternal morbidity and mortality worldwide. Our earlier studies suggest that altered metabolism of folic acid, vitamin B12 and long chain polyunsaturated fatty acid (LCPUFAs) in the one carbon cycle increases homocysteine levels in preeclampsia. Recent reports indicate that vitamin D deficiency may also have a role in preeclampsia, although the mechanisms are unclear...
March 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28223431/changes-in-the-glycosylation-of-kininogen-and-the-development-of-a-kininogen-based-algorithm-for-the-early-detection-of-hcc
#10
Mengjun Wang, Miloslav Sanda, Mary Ann Comunale, Harmin Herrera, Charles Swindell, Yuko Kono, Amit G Singal, Jorge A Marrero, Timothy Block, Radoslav Goldman, Anand Mehta
BACKGROUND: Hepatocellular carcinoma (HCC) has the greatest increase in mortality among all solids tumors in the United States related to low rates of early tumor detection. Development of non-invasive biomarkers for early detection of HCC may reduce HCC-related mortality. METHODS: We have developed an algorithm that combines routinely observed clinical values into a single equation that in a study of > 3,000 patients from 5 independent sites, improved detection of HCC as compared to the currently used biomarker, alpha-feto-protein (AFP), by 4-20%...
February 21, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28215301/neurotrophic-factors-and-maternal-nutrition-during-pregnancy
#11
M Dhobale
Maternal nutrition is one of the major determinants of pregnancy outcome. It has been suggested that reduced intakes or lack of specific nutrients during pregnancy influences the length of gestation, proper placental and fetal growth during pregnancy. Maternal nutrition, particularly micronutrients such as folate and vitamin B12, and long-chain polyunsaturated fatty acids (LCPUFA) are the major determinants of the one carbon cycle and are suggested to be at the heart of intrauterine programming of diseases in adult life...
2017: Vitamins and Hormones
https://www.readbyqxmd.com/read/28199380/the-effects-of-pravastatin-on-the-normal-human-placenta-lessons-from-ex-vivo-models
#12
Adelina Balan, Irit Szaingurten-Solodkin, Shani S Swissa, Valeria Feinshtein, Mahmoud Huleihel, Gershon Holcberg, Doron Dukler, Ofer Beharier
INTRODUCTION: Research in animal models and preliminary clinical studies in humans support the use of pravastatin for the prevention of preeclampsia. However, its use during pregnancy is still controversial due to limited data about its effect on the human placenta and fetus. METHODS: In the present study, human placental cotyledons were perfused in the absence or presence of pravastatin in the maternal reservoir (PraM). In addition, placental explants were treated with pravastatin for 5, 24 and 72 h under normoxia and hypoxia...
2017: PloS One
https://www.readbyqxmd.com/read/28170405/treatment-algorithm-based-on-the-multivariate-survival-analyses-in-patients-with-advanced-hepatocellular-carcinoma-treated-with-trans-arterial-chemoembolization
#13
Hasmukh J Prajapati, Hyun S Kim
PURPOSE: To develop the treatment algorithm from multivariate survival analyses (MVA) in patients with Barcelona clinic liver cancer (BCLC) C (advanced) Hepatocellular carcinoma (HCC) patients treated with Trans-arterial Chemoembolization (TACE). METHODS: Consecutive unresectable and non-tranplantable patients with advanced HCC, who received DEB TACE were studied. A total of 238 patients (mean age, 62.4yrs) was included in the study. Survivals were analyzed according to different parameters from the time of the 1st DEB TACE...
2017: PloS One
https://www.readbyqxmd.com/read/28169502/physiological-adaptation-of-maternal-plasma-volume-during-pregnancy-a-systematic-review-and-meta-analysis
#14
REVIEW
S de Haas, C Ghossein-Doha, S M J van Kuijk, J van Drongelen, M E A Spaanderman
OBJECTIVE: To describe the physiological pattern of gestational plasma volume adjustments in normal singleton pregnancy and compare this with the pattern in pregnancies complicated by pregnancy-induced hypertension, pre-eclampsia or fetal growth restriction. METHODS: We performed a meta-analysis of the current literature on plasma volume adjustments during physiological and complicated pregnancies. Literature was retrieved from PubMed (NCBI) and EMBASE (Ovid) databases...
February 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28166983/maternal-recognition-of-pregnancy-and-implantation-are-not-associated-with-an-interferon-response-of-the-endometrium-to-the-presence-of-the-conceptus-in-dromedary-camel
#15
Ahmed Sabry Salah Abdoon, Corrine Giraud-Delville, Omaima Mohamed Kandil, Annelye Kerboeuf-Giraud, Caroline Eozénou, Anais Vitorino Carvalho, Skidmore Julian, Olivier Sandra
Maternal recognition of pregnancy (MRP) and implantation involve appropriate interactions between the elongating conceptus and the receptive endometrium that will condition development of the feto-placental unit to term. Molecular mechanisms that take place at the conceptus-endometrium interface during early pregnancy have been extensively investigated in domestic ungulates but they are still poorly understood in camelids including the dromedary camel (Camelus dromedarius), a domestic species with important economic and social roles in arid and semi-arid areas...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28161055/maternal-type-1-diabetes-activates-stress-response-in-early-placenta
#16
Martin Gauster, Alejandro Majali-Martinez, Sabine Maninger, Elisabeth Gutschi, Patrick H Greimel, Marina Ivanisevic, Josip Djelmis, Gernot Desoye, Ursula Hiden
INTRODUCTION: Human pregnancy and in particular the first trimester, is a period highly susceptible towards adverse insults such as oxidative stress, which may lead to inadequate embryonic and feto-placental development. Diabetes mellitus is associated with increased oxidative stress caused by hyperglycemia, reactive oxygen species (ROS) production and inflammatory signals. In pregnancy, diabetes elevates the risk for early pregnancy loss, preeclampsia and fetal growth restriction, pathologies that origin from early placental maldevelopment...
February 2017: Placenta
https://www.readbyqxmd.com/read/28157247/congenital-diaphragmatic-hernia-pathogenesis-prenatal-diagnosis-and-management-literature-review
#17
Przemysław Kosiński, Mirosław Wielgoś
Congenital diaphragmatic hernia (CDH) is a developmental discontinuity of the diaphragm. It allows abdominal viscera to herniate into the chest and leads to lung hypoplasia. Congenital diaphragmatic hernia is one of the most severe birth defects, with extremely high neonatal mortality. This paper presents a review of the available literature on prenatal diagnosis, management and treatment options for CDH. In selected cases, a prenatal procedure to improve neonatal survival is possible. The authors of this manuscript believe their work might contribute to a better understanding of congenital diaphragmatic hernia and patient selection for the FETO (fetal endoscopic tracheal occlusion) surgery or expectant management...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28128425/analysis-of-specific-serum-markers-of-colon-carcinoma-using-a-bhattacharyya-based-support-vector-machine
#18
W Y Yang, G Shi, L P Wu, S T Wei, Y N Huang, L X Tan, R Z Yang, C X Yan, E T Guo, H Y Wang, J Z Tong, Y Dong, D Z Han
We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Bhattacharyya distance was used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma. The accuracy of the model was checked. High accuracy was assumed to indicate the high specificity of the index. The Bhattacharyya distances of carcinoembryonic antigen, neuron-specific enolase, alpha-feto protein, and CA724 were the largest, and those of CYFRA21-І, CA125, and UGT1A83 were the second largest...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28123837/heme-oxygenase-carbon-monoxide-in-the-female-reproductive-system-an-overlooked-signalling-pathway
#19
REVIEW
David Němeček, Markéta Dvořáková, Markéta Sedmíková
For a long time, carbon monoxide (CO) was known for its toxic effect on organisms. But there are still many things left to discover on that molecule. CO is formed directly in the body by the enzymatic activity of heme oxygenase (HO). CO plays an important role in many physiological processes, such as cell protections (against various stress factors), and the regulation of metabolic processes. Recent research proves that CO also operates in the female reproductive system. At the centre of interest is the importance of CO for gestation...
2017: International Journal of Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28112754/gdm-alters-paracrine-regulation-of-feto-placental-angiogenesis-via-the-trophoblast
#20
Jelena Loegl, Erika Nussbaumer, Silvija Cvitic, Berthold Huppertz, Gernot Desoye, Ursula Hiden
Feto-placental angiogenesis and vascular development are tightly regulated by pro- and anti-angiogenic factors. Villous trophoblast may be a major source of these factors. It forms the classical placental barrier between mother and fetus, and is thus exposed to maternal influences as well. Metabolic and hormonal derangements in gestational diabetes mellitus (GDM) affect feto-placental angiogenesis and vascular growth. Here we hypothesized that GDM alters the trophoblast secretome, which will modulate the paracrine regulation of feto-placental angiogenesis...
January 23, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
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