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Flavia Westphal, Suzete Maria Fustinoni, Vânia Lopes Pinto, Patrícia de Souza Melo, Anelise Riedel Abrahão
Objective: To identify the profile of women seen in a Fetal Medicine unit, diagnosed with fetal abnormality incompatible with neonatal survival in their current pregnancy, and to check the association of gestational age upon diagnosis with the option of pregnancy termination. Methods: This is a retrospective cohort study carried out in the Fetal Medicine Outpatients Clinic of a university hospital, in the city of São Paulo (SP), Brazil, using medical records of pregnant women with fetus presenting abnormalities incompatible with neonatal survival...
July 2016: Einstein
Yuta Yamada, Ken-Ichi Takayama, Tetsuya Fujimura, Daisaku Ashikari, Daisuke Obinata, Satoru Takahashi, Kazuhiro Ikeda, Shigenori Kakutani, Tomohiko Urano, Hiroshi Fukuhara, Yukio Homma, Satoshi Inoue
Tripartite motif 44 (TRIM44) is one of the TRIM family proteins that are involved in ubiquitination and degradation of target proteins by modulating E3 ubiquitin ligases. TRIM44 overexpression has been observed in various cancers. However, its association with testicular germ cell tumor (TGCT) is unknown. We aimed to investigate the clinical significance of TRIM44 and its function in TGCT. High expression of TRIM44 was significantly associated with alpha feto-protein levels, clinical stage, nonseminomatous germ cell tumor (NSGCT), and cancer-specific survival (P = 0...
October 18, 2016: Cancer Science
Marta Ferro, Hada C Macher, Pilar Noguerol, Pilar Jimenez-Arriscado, Patrocinio Molinero, Juan M Guerrero, Amalia Rubio
Fetal and Neonatal alloimmune thrombocytopenia (FNAIT) is a condition which could occur when pregnant women develop an alloimmunization against paternally inherited antigens of the fetal platelets. Approximately 80 % of FNAIT cases are caused by anti-HPA-1a, about 15 % by anti-HPA-5b and 5 % by other HPA antibodies. Only 2 % of the total population is HPA-1a negative (HPA-1b1b). The HPA-1a allele differs by one single nucleotide from HPA-1b allele, yet it represents around 27 % of total severe thrombocytopenias...
2016: Advances in Experimental Medicine and Biology
Yongsheng Zhu, Hong Lu, Zhenghao Huo, Zhanbin Ma, Jie Dang, Wei Dang, Lin Pan, Jing Chen, Huijun Zhong
Recurrent spontaneous abortion (RSA) is a common health problem that affects women of reproductive age. Recent studies have indicated that microRNAs are important factors in miscarriage. This study investigated the role of miR-16 in regulating vascular endothelial growth factor (VEGF) expression and the pathogenesis of RSA. In this report, clinical samples revealed that miR-16 expression was significantly elevated in the villi and decidua of RSA patients. In vitro, miR-16 upregulation inhibited human umbilical vein endothelial cell proliferation, migration and tube formation...
October 17, 2016: Scientific Reports
Chia-Yih Wang, Hui-Ling Tsai, Jhih-Siang Syu, Ting-Yu Chen, Mei-Tsz Su
Trophoblast invasion is an important event in embryo implantation and placental development. During these processes, endocrine gland-derived vascular endothelial growth factor (EG-VEGF) is the key regulator mediating the crosstalk at the feto-maternal interface. The primary cilium is a cellular antenna receiving environmental signals and is crucial for proper development. However, little is known regarding the role of the primary cilium in early human pregnancy. Here, we demonstrate that EG-VEGF regulates trophoblast cell invasion via primary cilia...
October 13, 2016: Journal of Cellular Physiology
Qianlan Yang, Wangsheng Wang, Chao Liu, Yu Wang, Kang Sun
Glucocorticoids are engaged in a number of actions at the feto-maternal interface for the establishment of early pregnancy. However, excessive glucocorticoids can be deleterious to fetal development. Therefore, compartmentalized distribution of 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 2), which regenerates and inactivates cortisol respectively, would ensure an optimal cortisol concentration at the feto-maternal interface for the establishment of early gestation. However, the distribution pattern of 11β-HSD1 and 2 at the feto-maternal interface in early human pregnancy is not clearly defined...
October 2016: Placenta
Jesenia Acurio, Kurt Herlitz, Felipe Troncoso, Claudio Aguayo, Patricio Bertoglia, Carlos Escudero
We aim to investigate whether A2A/nitric oxide-mediated regulation of vascular endothelial growth factor (VEGF) expression is impaired in feto-placental endothelial cells from late-onset pre-eclampsia. Cultures of human umbilical vein endothelial cells (HUVECs) and human placental microvascular endothelial cells (hPMECs) from normal and pre-eclamptic pregnancies were used. Assays by using small interference RNA (siRNA) for A2A were performed, and transfected cells were used for estimation of messenger RNA (mRNA) levels of VEGF, as well as for cell proliferation and angiogenesis in vitro...
September 30, 2016: Purinergic Signalling
Sangita Nangia Ajmani, Mohini Paul, Poonam Chauhan, A K Ajmani, Namrta Yadav
AIM: To assess the prevalence of vitamin D deficiency in burka-clad pregnant women and to study feto-maternal outcome in these women. METHODS: 200 pregnant burka-clad women of 18-40-year age group irrespective of the period of gestation were recruited from the ANC OPD/ward of Kasturba hospital, and their vitamin D levels were estimated. Patients were categorized into vitamin D deficient, vitamin D inadequate, and vitamin D adequate according to The Endocrine Society Guidelines...
October 2016: Journal of Obstetrics and Gynaecology of India
Manisha Vernekar, Roy Rajib
INTRODUCTION: Uterine rupture is a catastrophic obstetrical emergency associated with a significant feto-maternal morbidity and mortality. Many risk factors for uterine rupture, as well as a wide range of clinical presentations, have been identified. OBJECTIVES: To analyze the frequency, predisposing factors, and maternal and fetal outcomes of uterine rupture. METHODS: A retrospective analysis of cases of unscarred uterine rupture was conducted at the Department of Obstetrics and Gynecology, RIMS, Imphal from June 1, 2010 to June 30, 2012...
October 2016: Journal of Obstetrics and Gynaecology of India
Edward Araujo Júnior, Gabriele Tonni, Wellington P Martins, Rodrigo Ruano
No abstract text is available yet for this article.
September 20, 2016: European Journal of Pediatric Surgery
J Degenhardt, C Enzensberger, A Tenzer, A Kawecki, T Kohl, E Widriani, R Axt-Fliedner
: Purpose: To evaluate pre- and postprocedural myocardial function in fetuses with moderate to severe congenital diaphragmatic hernia (CDH) who underwent FETO to improve survival and to reduce morbidity and to compare these data with fetuses and CDH not undergoing FETO and normal controls. Materials and Methods: 8 fetuses with isolated left-sided CDH were included and underwent FETO at our center between 2012 and 2013. Prior to and after the operation, myocardial function was assessed by measuring the mitral annular plane systolic excursion (MAPSE), the tricuspid annular plane systolic excursion (TAPSE), Tei index, isovolumetric contraction time (ICT), ejection time (ET), isovolumetric relaxation time (IRT) for the left ventricle in PW Doppler ultrasound as well as ICT, ET, IRT and Tei index in pulsed wave tissue Doppler imaging (PW-TDI) for the left and right ventricle...
September 14, 2016: Ultraschall in der Medizin
Eman A Toraih, Manal S Fawzy, Abdullah I El-Falouji, Elham O Hamed, Nader A Nemr, Mohammad H Hussein, Noha M Abd El Fadeal
Stem cell transcriptional signature activation is an essential event in the development of cancer. This study aimed to investigate the differential expression profile of three pluripotency-associated genes (OCT4, NANOG, and SOX2), G-protein-coupled chemokine receptor 4 (CXCR4) and the ligand (CXCL2), and alpha feto-protein (AFP) in hepatogenic differentiated stem cells and in sera of hepatitis C virus (HCV) and HCV-induced hepatocellular carcinoma (HCC) patients. Mesenchymal stem cells derived from umbilical cord blood were differentiated using hepatogenic differentiation media...
September 12, 2016: Molecular Medicine
Folusho D Adeyinka, Richard A Laven, Gina Denicolo, Kevin E Lawrence, Timothy J Parkinson
The functional surface areas of the feto-maternal unit of the bovine placentomes were quantified from Day 100 to 260 of gestation by using stereology. This study was achieved using intact placentomes obtained from an abattoir. There was no change in volume and surface densities of binucleate cells, fetal trophoblast, fetal and maternal tissues, and maternal epithelium with gestation age, although the total volume of these components increased with gestation age from Day 126 to 260. The total surface area of the feto-maternal interface increased in a similar pattern as the placentomal components without a change in the fetal to maternal tissue ratio when estimated with stereology...
September 9, 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Martha M Kirstein, Nora Schweitzer, Nazli Ay, Christina Boeck, Katerina Lappas, Jan B Hinrichs, Torsten Voigtländer, Frank Wacker, Michael P Manns, Thomas Rodt, Arndt Vogel
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most lethal cancers. Transarterial chemoembolization (TACE) has been accepted as the standard of care for intermediate stage disease. METHODS: In this study, we characterized 606 HCC patients from Hannover Medical School treated with TACE. RESULTS: 606 HCC patients treated with TACE were identified between 2000 and 2015. Most patients (59.8%) were at intermediate stage. Following TACE, most patients subsequently received systemic therapy or best supportive care (BSC), whereas 227 (37...
September 6, 2016: Scandinavian Journal of Gastroenterology
Sultan Ayoub Meo, Asim Hassain
The metabolic physiology during pregnancy is unique in the life of women. This change is a normal physiological adaptation to better accommodate the foetal growth and provides adequate blood, nutrition and oxygen. The metabolic changes prepare the mother\'s body for pregnancy, childbirth and lactation. Early gestational period is considered as an anabolic phase, in which female body stores nutrients, enhance insulin sensitivity to encounter the maternal and feto-placental demands of late gestation and lactation...
September 2016: JPMA. the Journal of the Pakistan Medical Association
Sarwat I Gilani, Tracey L Weissgerber, Vesna D Garovic, Muthuvel Jayachandran
Preeclampsia is a hypertensive pregnancy disorder characterized by development of hypertension and proteinuria after 20 weeks of gestation that remains a leading cause of maternal and neonatal morbidity and mortality. While preeclampsia is believed to result from complex interactions between maternal and placental factors, the proximate pathophysiology of this syndrome remains elusive. Cell-to-cell communication is a critical signaling mechanism for feto-placental development in normal pregnancies. One mechanism of cellular communication relates to activated cell-derived sealed membrane vesicles called extracellular vesicles (EVs)...
September 2016: Current Hypertension Reports
Manalee Vishnu Surve, Anjali Anil, Kshama Ganesh Kamath, Smita Bhutda, Lakshmi Kavitha Sthanam, Arpan Pradhan, Rohit Srivastava, Bhakti Basu, Suryendu Dutta, Shamik Sen, Deepak Modi, Anirban Banerjee
Infection of the genitourinary tract with Group B Streptococcus (GBS), an opportunistic gram positive pathogen, is associated with premature rupture of amniotic membrane and preterm birth. In this work, we demonstrate that GBS produces membrane vesicles (MVs) in a serotype independent manner. These MVs are loaded with virulence factors including extracellular matrix degrading proteases and pore forming toxins. Mice chorio-decidual membranes challenged with MVs ex vivo resulted in extensive collagen degradation leading to loss of stiffness and mechanical weakening...
September 2016: PLoS Pathogens
Sultan Ayoub Meo, Asim Hassain
The metabolic physiology during pregnancy is unique in the life of women. This change is a normal physiological adaptation to better accommodate the foetal growth and provides adequate blood, nutrition and oxygen. The metabolic changes prepare the mother\'s body for pregnancy, childbirth and lactation. Early gestational period is considered as an anabolic phase, in which female body stores nutrients, enhance insulin sensitivity to encounter the maternal and feto-placental demands of late gestation and lactation...
September 2016: JPMA. the Journal of the Pakistan Medical Association
Rosa María Martínez García
El embarazo representa un desafío desde el punto de vista nutricional, debido a que las necesidades de nutrientes están aumentadas y una alteración en su ingesta puede afectar la salud materno-fetal. Estados deficitarios en micronutrientes están relacionados con preeclampsia, retraso del crecimiento intrauterino, aborto y anomalías congénitas. Actualmente, la dieta de muchas madres gestantes es insuficiente en micronutrientes, siendo necesaria su suplementación. Se recomienda la suplementación con ácido fólico en dosis de 400 μg/día, y de 5 mg en embarazadas de riesgo, debiendo comenzar al menos 1 mes antes de la concepción y durante las primeras 12 semanas de gestación, y prolongarla durante todo el embarazo en madres con riesgo nutricional...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Jorge R Pasqualini, Gérard S Chetrite
The fetal endocrine system constitutes the earliest system developing in fetal life and operates during all the steps of gestation. Its regulation is in part dependent on the secretion of placental and/or maternal precursors emanating across the feto-maternal interface. Human fetal and placental compartments possess all the enzymatic systems necessary to produce steroid hormones. However, their activities are different and complementary: the fetus is very active in converting acetate into cholesterol, in transforming pregnanes to androstanes, various hydroxylases, sulfotransferases, while all these transformations are absent or very limited in the placenta...
July 1, 2016: Hormone Molecular Biology and Clinical Investigation
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