Lucia Del-Valle-Anton, Salma Amin, Daniela Cimino, Florian Neuhaus, Elena Dvoretskova, Virginia Fernández, Yigit K Babal, Cristina Garcia-Frigola, Anna Prieto-Colomina, Raquel Murcia-Ramón, Yuki Nomura, Adrián Cárdenas, Chao Feng, Juan Antonio Moreno-Bravo, Magdalena Götz, Christian Mayer, Víctor Borrell
Cortical neurogenesis follows a simple lineage: apical radial glia cells (RGCs) generate basal progenitors, and these produce neurons. How this occurs in species with expanded germinal zones and a folded cortex, such as human, remains unclear. We used single-cell RNA sequencing from individual cortical germinal zones in ferret and barcoded lineage tracking to determine the molecular diversity of progenitor cells and their lineages. We identified multiple RGC classes that initiate parallel lineages, converging onto a common class of newborn neuron...
March 29, 2024: Science Advances