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https://www.readbyqxmd.com/read/29786911/esipt-modulated-emission-of-lanthanide-complexes-different-energy-transfer-pathway-and-multi-responses
#1
Si-Si Sun, Zheng Wang, Xiang Wen Wu, Jian-Hua Zhang, Chao-Jie Li, Shao-Yun Yin, Ling Chen, Mei Pan, Cheng-Yong Su
Two series of isostructural lanthanide coordination complexes, namely, LIFM-42(Ln), Ln = Eu, Tb, Gd, and LIFM-43(Ln), Ln = Er, Yb) were synthesized through the self-assembly of an ESIPT (excited-state intramolecular proton transfer) ligand, H2hpi2cf (5-(2-(5-fluoro-2-hydroxyphenyl)-4,5-bis(4-fluorophenyl)-1H-imidazol-1-yl)isophthalic acid) with different lanthanide ions. In the coordination structures linked by the ligands and oxo-bridged LnIII2 clusters (for LIFM-42(Ln) series) or isolated LnIII ions (for LIFM-43(Ln) series), the ESIPT ligand can serve as both the host and antenna for protecting and sensitizing the photoluminescence (PL) of LnIII ions...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29786888/injectable-bioresponsive-gel-depot-for-enhanced-immune-checkpoint-blockade
#2
Shuangjiang Yu, Chao Wang, Jicheng Yu, Jinqiang Wang, Yue Lu, Yuqi Zhang, Xudong Zhang, Quanyin Hu, Wujin Sun, Chaoliang He, Xuesi Chen, Zhen Gu
Although cancer immunotherapy based on immune checkpoint inhibitors holds great promise toward many types of cancers, several challenges still remain, associated with low objective response of patient rate as well as systemic side effects. Here, a combination immunotherapy strategy is developed based on a thermogelling reactive oxygen species (ROS)-responsive polypeptide gel for sustained release of anti-programmed cell death-ligand 1 antibody and dextro-1-methyl tryptophan, inhibitor of indoleamine-2,3-dioxygenase with leveraging the ROS level in the tumor microenvironment...
May 22, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29786731/regioselective-and-diastereoselective-synthesis-of-two-functionalized-1-5-methanoindeno-1-2-d-azocines-via-a-three-component-reaction
#3
Jun Cao, Jing Sun, Chao-Guo Yan
The morpholine promoted three-component reaction of N-alkylpiperidinone, indane-1,3-dione and 2-arylideneindane-1,3-dione in ethanol at room temperature resulted in the (1H-1,5-methanoindeno[1,2-d]azocin-12-ylidene)-1H-indene-1,3(2H)-dione derivatives in good yields and with exo-configuration. Under similar conditions, the reaction of N-alkylpiperidinone with 2-arylideneindane-1,3-dione afforded 7H-1,5-methanoindeno[1,2-d]azocine-7,12-diones with endo-configuration. The domino reaction is believed to proceed with domino Knoevenagel condensation, Michael addition and aldol condensation reaction...
May 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29786485/organized-chaos-does-pi-rads-version-2-work-in-the-transition-zone
#4
Jeffrey C Weinreb
No abstract text is available yet for this article.
May 17, 2018: Radiology
https://www.readbyqxmd.com/read/29786099/cluster-to-cluster-transformation-among-au-6-au-8-and-au-11-nanoclusters
#5
Xiuqing Ren, Junhong Fu, Xinzhang Lin, Xuemei Fu, Jinghui Yan, Ren'an Wu, Chao Liu, Jiahui Huang
We present the cluster-to-cluster transformations among three gold nanoclusters, [Au6(dppp)4]2+ (Au6), [Au8(dppp)4Cl2]2+ (Au8) and [Au11(dppp)5]3+ (Au11). The conversion process follows a rule that states that the transformation of a small cluster to a large cluster is achieved through an oxidation process with an oxidizing agent (H2O2) or with heating, while the conversion of a large cluster to a small one occurs through a reduction process with a reducing agent (NaBH4). All the reactions were monitored using UV-Vis spectroscopy and ESI-MS...
May 22, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29786047/establishment-of-a-quantitative-medical-technology-evaluation-system-and-indicators-within-medical-institutions
#6
Suo-Wei Wu, Tong Chen, Qi Pan, Liang-Yu Wei, Qin Wang, Chao Li, Jing-Chen Song, Ji Luo
Background: The development and application of medical technologies reflect the medical quality and clinical capacity of a hospital. It is also an effective approach in upgrading medical service and core competitiveness among medical institutions. This study aimed to build a quantitative medical technology evaluation system through questionnaire survey within medical institutions to perform an assessment to medical technologies more objectively and accurately, and promote the management of medical quality technologies and ensure the medical safety of various operations among the hospitals...
June 5, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29785970/phenotypic-and-molecular-characteristics-of-androgen-insensitivity-syndrome-patients
#7
Shi-Min Yuan, Ya-Nan Zhang, Juan Du, Wen Li, Chao-Feng Tu, Lan-Lan Meng, Ge Lin, Guang-Xiu Lu, Yue-Qiu Tan
Androgen insensitivity syndrome (AIS), an X-linked recessive genetic disorder of sex development, is caused by mutations in the androgen receptor (AR) gene, and is characterized by partial or complete inability of specific tissues to respond to androgens in individuals with the 46,XY karyotype. This study aimed to investigate AR gene mutations and to characterize genotype-phenotype correlations. Ten patients from unrelated families, aged 2-31 years, were recruited in the study. Based on karyotype, altered hormone profile, and clinical manifestations, nine patients were preliminarily diagnosed with complete AIS and one with partial AIS...
May 18, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29785947/-n-wasp-regulates-cortical-neuron-migration-through-its-polypro-and-vca-domains
#8
Xiu Lian Shen, Yi Chao Lu, Zhi Lian Jia, Qiang Wu
Cortical neuron migration in the developing mouse forebrain is a complex process, which contains several steps related to cytoskeleton dynamics and remodeling. Neural Wiskott-Aldrich syndrome protein (N-WASP), a member of the WASP-WAVE family, regulates actin cytoskeleton reorganization through the binding of its VCA domain to the Arp2/3 complex. Here we report expression patterns of N-WASP gene in the mouse developing embryonic cortex (E12.5~ E18.5) and find its expression levels are decreased during embryonic development...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29785944/-overview-of-the-genetic-control-of-horse-coat-color-patterns
#9
Ruo Yang Zhao, Yi Ping Zhao, Bei Li, Gerelchimeg Bou, Xin Zhuang Zhang, Togtokh Mongke, Tugeqin Bao, Shurenchimeg Gereliin, Tsimbai Gereltuuin, Chao Li, Dong Yi Bai, Mang Lai Dugarjaviin
Mammalian coat color is one of the first phenotypic changes resulting from positive selection by humans, and it serves important roles in genetic and evolutionary processes. Among them, horses show a broad variety of coat color patterns, based on which it is difficult to distinguish the real phenotypes, resulting in confused records in horse breed registration. Thus, research in the genetic mechanisms on the development of coat color patterns is significant in horse reproduction and breeding. With the recent establishment of genomics and sequencing technologies, there are significant advances in research in the genetics of horse coat colors, which demonstrate that special coat colors could be associated with certain diseases...
May 20, 2018: Yi Chuan, Hereditas
https://www.readbyqxmd.com/read/29785850/performance-enhancement-of-inverted-perovskite-solar-cells-based-on-smooth-and-compact-pc61bm-sno2-electron-transport-layers
#10
Yao Wang, Chenghao Duan, Jiangsheng Li, Wei Han, Min Zhao, Lili Yao, Yuanyuan Wang, Chao Yan, Tonggang Jiu
In this work, PC61BM:SnO2 electron transport layers (ETLs) were applied in inverted CH3NH3PbI3 perovskite solar cells and a high power conversion efficiency of 19.7% could be obtained. It increased by 49.0% in comparison with the device based on PC61BM-only ETL (13.2%). SnO2 nanocrystals with excellent dispersibility were employed here to fill the pin-holes and cover the valleys of PC61BM layer, forming smooth and compact PC61BM:SnO2 layers. Simultaneously, the electron traps caused by deep-level native defects of SnO2 were reduced by PC61BM proved by the space charge limited current analysis...
May 22, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29785518/fumarylacetoacetate-hydrolase-is-involved-in-salt-stress-response-in-arabidopsis
#11
Lihua Huang, Chao Hu, Wei Cai, Qi Zhu, Bida Gao, Xuewen Zhang, Chunmei Ren
Fumarylacetoacetate hydrolase participates in positive regulation of salt stress in Arabidopsis. Fumarylacetoacetate hydrolase (FAH) catalyzes the hydrolysis of fumarylacetoacetate into fumarate and acetoacetate, the final step in the Tyr degradation pathway that is essential to animals. However, the Tyr degradation pathway is not well understood in plants. Previously, we found that mutation of the SHORT-DAY SENSITIVE CELL DEATH 1 (SSCD1) gene encoding FAH in Arabidopsis causes spontaneous cell death under short day, which first indicated that the Tyr degradation pathway also plays an important role in plants...
May 21, 2018: Planta
https://www.readbyqxmd.com/read/29785468/competition-for-electrons-between-mono-oxygenations-of-pyridine-and-2-hydroxypyridine
#12
Chao Yang, Yingxia Tang, Hua Xu, Ning Yan, Naiyu Li, Yongming Zhang, Bruce E Rittmann
Pyridine and its heterocyclic derivatives are widely encountered in industrial wastewaters, and they are relatively recalcitrant to biodegradation. Pyridine biodegradation is initiated by two mono-oxygenation reactions that compete for intracellular electron donor (2H). In our experiments, UV photolysis of pyridine generated succinate, whose oxidation augmented the intracellular electron donor and accelerated pyridine biodegradation and mineralization. The first mono-oxygenation reaction always was faster than the second one, because electrons provided by intracellular electron donors were preferentially utilized by the first mono-oxygenase; this was true even when the concentration of 2HP was greater than the concentration of pyridine...
May 21, 2018: Biodegradation
https://www.readbyqxmd.com/read/29785125/-znf418-overexpression-protects-against-gastric-carcinoma-and-prompts-a-good-prognosis
#13
Hong-Xia Hui, Zhong-Wu Hu, Chao Jiang, Jian Wu, Yong Gao, Xiao-Wei Wang
Background: This study aimed to investigate the prognostic power of zinc-finger protein 418 ( ZNF418 ) in gastric cancer (GC) and its potential role in GC development and progression. Patients and methods: A total of 10 GC patients' individual plasmas were collected and screened for dysregulated mRNA using human microarray. Among these dysregulated mRNAs, ZNF418 was found to be significantly downregulated in IIIA-IV stage GC patients compared to IA-IIA stage GC patients...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29785030/landau-zener-st%C3%A3-ckelberg-interferometry-for-majorana-qubit
#14
Zhi Wang, Wen-Chao Huang, Qi-Feng Liang, Xiao Hu
Stimulated by a recent experiment observing successfully two superconducting states with even- and odd-number of electrons in a nanowire topological superconductor as expected from the existence of two end Majorana quasiparticles (MQs) [Albrecht et al., Nature 531, 206 (2016)], we propose a way to manipulate Majorana qubit exploiting quantum tunneling effects. The prototype setup consists of two one-dimensional (1D) topological superconductors coupled by a tunneling junction which can be controlled by gate voltage...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29785024/targeting-skeletal-endothelium-to-ameliorate-bone-loss
#15
Ren Xu, Alisha Yallowitz, An Qin, Zhuhao Wu, Dong Yeon Shin, Jung-Min Kim, Shawon Debnath, Gang Ji, Mathias P Bostrom, Xu Yang, Chao Zhang, Han Dong, Pouneh Kermani, Sarfaraz Lalani, Na Li, Yifang Liu, Michael G Poulos, Amanda Wach, Yi Zhang, Kazuki Inoue, Annarita Di Lorenzo, Baohong Zhao, Jason M Butler, Jae-Hyuck Shim, Laurie H Glimcher, Matthew B Greenblatt
Recent studies have identified a specialized subset of CD31hi endomucinhi (CD31hi EMCNhi ) vascular endothelium that positively regulates bone formation. However, it remains unclear how CD31hi EMCNhi endothelium levels are coupled to anabolic bone formation. Mice with an osteoblast-specific deletion of Shn3, which have markedly elevated bone formation, demonstrated an increase in CD31hi EMCNhi endothelium. Transcriptomic analysis identified SLIT3 as an osteoblast-derived, SHN3-regulated proangiogenic factor...
May 21, 2018: Nature Medicine
https://www.readbyqxmd.com/read/29785022/novel-peptide-gx1-inhibits-angiogenesis-by-specifically-binding-to-transglutaminase-2-in-the-tumorous-endothelial-cells-of-gastric-cancer
#16
Zhijie Lei, Na Chai, Miaomiao Tian, Ying Zhang, Guodong Wang, Jian Liu, Zuhong Tian, Xiaofang Yi, Di Chen, Xiaowei Li, Pengfei Yu, Hao Hu, Bing Xu, Chao Jian, Zhenyuan Bian, Hao Guo, Jinpeng Wang, Shiming Peng, Yongzhan Nie, Niu Huang, Sijun Hu, Kaichun Wu
The clinical application of GX1, an optimal gastric cancer (GC) targeting peptide, is greatly limited because its receptor in the GC vasculature is unknown. In this study, we screened the candidate receptor of GX1, transglutaminase-2(TGM2), by co-immunoprecipitation (co-IP) combined with mass spectrometry. We found that TGM2 was up-regulated in GC vascular endothelial cells and that GX1 receptor expression was suppressed correspondingly after TGM2 downregulation. A highly consistent co-localization of GX1 receptor and TGM2 was detected at both the cellular and tissue levels...
May 21, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29784968/ultranarrow-bandwidth-filter-based-on-a-thermal-eit-medium
#17
Gang Wang, Yu-Sheng Wang, Emily Kay Huang, Weilun Hung, Kai-Lin Chao, Ping-Yeh Wu, Yi-Hsin Chen, Ite A Yu
We present high-contrast electromagnetically-induced-transparency (EIT) spectra in a heated vapor cell of single isotope 87 Rb atoms. The EIT spectrum has both high resonant transmission up to 67% and narrow linewidth of 1.1 MHz. We get rid of the possible amplification resulted from the effects of amplification without population inversion and four-wave mixing. Therefore, this high transmitted light is not artificial. The theoretical prediction of the probe transmission agrees well with the data and the experimental parameters can be derived reasonably from the model...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784944/value-of-urinary-kim-1-and-ngal-combined-with-serum-cys-c-for-predicting-acute-kidney-injury-secondary-to-decompensated-cirrhosis
#18
Lei Lei, Liang Ping Li, Zhen Zeng, Jing Xi Mu, Xue Yang, Chao Zhou, Zhi Lan Wang, Hu Zhang
Urinary kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and serum cystatin C (Cys C) are biomarkers of acute kidney injury (AKI). However, the efficacy of combining these indices to diagnose decompensated cirrhosis is unknown. This study involved 150 patients divided into AKI and non-AKI, and healthy individuals. Urinary KIM-1 and NGAL, serum Cys and creatine, and glomerular filtration rate (GFR) were compared based on Child-Pugh liver function class. Urinary KIM-1 and NGAL concentrations and serum Cys C levels were significantly higher in patients with AKI secondary to decompensated cirrhosis than in those with AKI not secondary to decompensated cirrhosis (p < 0...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784937/an-oil-free-picodrop-bioassay-platform-for-synthetic-biology
#19
Christian A Siltanen, Russell H Cole, Sean Poust, Lawrence Chao, Jabus Tyerman, Benjamin Kaufmann-Malaga, Jeff Ubersax, Zev J Gartner, Adam R Abate
Droplet microfluidics enables massively-parallel analysis of single cells, biomolecules, and chemicals, making it valuable for high-throughput screens. However, many hydrophobic analytes are soluble in carrier oils, preventing their quantitative analysis with the method. We apply Printed Droplet Microfluidics to construct defined reactions with chemicals and cells incubated under air on an open array. The method interfaces with most bioanalytical tools and retains hydrophobic compounds in compartmentalized reactors, allowing their quantitation...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29784720/reader-response-blood-pressure-reduction-and-noncontrast-ct-markers-of-intracerebral-hemorrhage-expansion
#20
Zengpanpan Ye, Jun Zheng, Chao You
No abstract text is available yet for this article.
May 22, 2018: Neurology
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