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https://www.readbyqxmd.com/read/29150478/early-versus-late-application-of-subthalamic-deep-brain-stimulation-to-parkinson-s-disease-patients-with-motor-complications-elass-protocol-of-a-multicentre-prospective-and-observational-study
#1
Lulu Jiang, Wai Sang Poon, Elena Moro, Wenbiao Xian, Chao Yang, Xian Lun Zhu, Jing Gu, Xiaodong Cai, Jinlong Liu, Vincent Mok, Yanmei Liu, Shaohua Xu, Qiyu Guo, Wanru Chen, Ling Chen
INTRODUCTION: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established surgical treatment for Parkinson's disease (PD). However, there is currently no consensus on the best timing for this surgery. The aim of our study is to compare the therapeutic efficacy of bilateral STN DBS in patients with PD with early and late motor complications. METHODS AND ANALYSIS: 200 patients with PD will be enrolled in this multicentre, prospective, observational study, and will be followed up for 4 years...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29149705/toll-like-receptor-4-deficiency-increases-resistance-in-sepsis-induced-immune-dysfunction
#2
Chao Cao, Yanfen Chai, Songtao Shou, Jun Wang, Ying Huang, Tao Ma
Sepsis constitutes a serious life-threatening syndrome associated with complications of deregulated inflammatory response against endotoxin/lipopolysaccharide (LPS)-mediated severe infection. Toll-like receptor 4 (TLR4) plays a critical role in the activation of innate immunity through recognition of LPS. However, the impact of TLR4 signaling on the development of sepsis-induced immune dysfunction remains unclear. The aim of this study was to investigate the effect of TLR4 on regulatory T cells (Tregs) and its potential mechanism...
November 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29149608/a-distinct-gene-module-for-dysfunction-uncoupled-from-activation-in-tumor-infiltrating-t-cells
#3
Meromit Singer, Chao Wang, Le Cong, Nemanja D Marjanovic, Monika S Kowalczyk, Huiyuan Zhang, Jackson Nyman, Kaori Sakuishi, Sema Kurtulus, David Gennert, Junrong Xia, John Y H Kwon, James Nevin, Rebecca H Herbst, Itai Yanai, Orit Rozenblatt-Rosen, Vijay K Kuchroo, Aviv Regev, Ana C Anderson
No abstract text is available yet for this article.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29149508/implementing-quantum-search-algorithm-with-metamaterials
#4
Weixuan Zhang, Kaiyang Cheng, Chao Wu, Yi Wang, Hongqiang Li, Xiangdong Zhang
Metamaterials, artificially structured electromagnetic (EM) materials, have enabled the realization of many unconventional EM properties not found in nature, such as negative refractive index, magnetic response, invisibility cloaking, and so on. Based on these man-made materials with novel EM properties, various devices are designed and realized. However, quantum analog devices based on metamaterials have not been achieved so far. Here, metamaterials are designed and printed to perform quantum search algorithm...
November 17, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29149472/which-commonly-monitored-chemical-contaminant-in-the-bohai-region-yangtze-and-pearl-rivers-of-china-poses-the-greatest-threat-to-aquatic-wildlife
#5
Andrew C Johnson, Monika D Jürgens, Chao Su, Meng Zhang, Yueqing Zhang, Yajuan Shi, Andrew Sweetman, Xiaowei Jin, Yonglong Lu
This study assessed the relative risk of 29 chemical contaminants to aquatic wildlife in the Bohai Region, Yangtze and Pearl Rivers of China. River monitoring data from 2010-2015 for metals, pesticides, plasticisers, surfactants, poly-aromatic hydrocarbons, flame retardants and ammonia were collected. For each chemical, ecotoxicity data were compiled for Chinese relevant aquatic species. The chemicals were ranked by relative risk either by comparing the ratios of the median river concentration divided by the median ecotoxicity concentration or the percentage of river measurements which exceeded the lower 10(th) percentile ecotoxicity value...
November 17, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29149454/melatonin-alleviates-adipose-inflammation-through-elevating-%C3%AE-ketoglutarate-and-diverting-adipose-derived-exosomes-to-macrophages-in-mice
#6
Zhenjiang Liu, Lu Gan, Tiantian Zhang, Qian Ren, Chao Sun
Obesity is associated with macrophage infiltration and metabolic inflammation, both of which promote metabolic disease progression. Melatonin is reported to possess anti-inflammatory properties by inhibiting inflammatory response of adipocytes and macrophages activation. However, the effects of melatonin on the communication between adipocytes and macrophages during adipose inflammation remain elusive. Here, we demonstrated melatonin alleviated inflammation and elevated α-ketoglutarate (αKG) level in adipose tissue of obese mice...
November 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/29149144/the-efficacy-of-preoperative-gabapentin-in-spinal-surgery-a-meta-analysis-of-randomized-controlled-trials
#7
Chao Han, Ming-Jie Kuang, Jian-Xiong Ma, Xin-Long Ma
BACKGROUND: Pain management after spinal surgery has been studied for years. Gabapentin is a third-generation antiepileptic drug that selectively affects the nociceptive process and has been used for pain relief after surgery. However, the relationship between gabapentin and postoperative pain in spinal surgery is still controversial. OBJECTIVE: To assess the efficacy of the pre-emptive use of gabapentin in spinal surgery. STUDY DESIGN: A meta-analysis of randomized controlled studies...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/29149054/a-dual-polymer-fiber-fizeau-interferometer-for-simultaneous-measurement-of-relative-humidity-and-temperature
#8
Chao-Tsung Ma, Yu-Wei Chang, Yuan-Jie Yang, Cheng-Ling Lee
This paper presents a novel design method in which a dual-polymer fiber Fizeau interferometer (DPFFI) is proposed for simultaneously measuring relative humidity (RH) and temperature (T). Since the polymer is intrinsically highly sensitive to both RH and T, the polymer fiber Fizeau interferometer (PFFI) exhibits cross-sensitivity of RH and T. In general, it is difficult to demodulate the optical responses from both variations of RH and T using a single PFFI. If two PFFIs with different structures are combined, they will individually exhibit distinct sensitivity responses with respect to RH and T, respectively...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149050/combining-a-disturbance-observer-with-triple-loop-control-based-on-mems-accelerometers-for-line-of-sight-stabilization
#9
Yong Luo, Yongmei Huang, Chao Deng, Yao Mao, Wei Ren, Qiongyan Wu
In the CCD-based fine tracking optical system (FTOS), the whole disturbance suppression ability (DSA) is the product of the inner loop and outer position loop. Traditionally, high sampling fiber-optic gyroscopes (FOGs) are added to the platform to stabilize the line-of-sight (LOS). However, because of the FOGs' high cost and relatively big volume relative to the back narrow space of small rotating mirrors, we attempt in this work to utilize a cheaper and smaller micro-electro-mechanical system (MEMS) accelerometer to build the inner loop, replacing the FOG...
November 17, 2017: Sensors
https://www.readbyqxmd.com/read/29149016/oleanane-type-saponins-from-the-roots-of-ligulariopsis-shichuana-and-their-%C3%AE-glucosidase-inhibitory-activities
#10
Hai-Bo Wu, Ting-Ting Liu, Wen-Shu Wang, Jin-Chao Feng, Hong-Mei Tian
Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of Ligulariopsis shichuana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects and exhibited potent inhibition against α-glucosidase, while compounds 1 and 2 showed excellent inhibitory activities...
November 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29149007/awake-bronchoscopic-intubation-with-a-noninvasive-positive-pressure-support-in-critically-ill-patients
#11
Fu-Shan Xue, Gui-Zhen Yang, Chao Wen
No abstract text is available yet for this article.
December 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29148984/supercritical-diethylamine-facilitated-loading-of-ultrafine-ru-particles-on-few-layer-graphene-for-solvent-free-hydrogenation-of-levulinic-acid-to-%C3%AE-valerolactone
#12
Tao Hengcong, Jingjing Ding, Chao Xie, Yunnan Gao, Jinliang Song, Zhenyu Sun
We demonstrate a facile and versatile method to grow Ru particles uniformly on pristine few-layer graphene (FLG) in supercritical diethylamine. In particular, a large number of Ru subnanometer clusters less than 1.0 nm were observed. The particle size can be tuned by manipulating the loading content of Ru and controlling the reaction temperature. The resulting Ru/FLG showed remarkably high activity, selectivity, and reusability towards the hydrogenation of levulinic acid to γ-valerolactone. This method is flexible, and can be extended to the synthesis of a variety of other ultrafine metal particles supported on FLG...
November 17, 2017: Nanotechnology
https://www.readbyqxmd.com/read/29148797/nigegladines-a-c-three-thymoquinone-dimers-from-nigella-glandulifera
#13
Jie Tian, Chao Han, Wen-Hua Guo, Yong Yin, Xiao-Bing Wang, Hong-Bin Sun, He-Quan Yao, Yong Yang, Chen Wang, Chang Liu, Ming-Hua Yang, Ling-Yi Kong
Nigegladines A-C (1-3), three thymoquinone dimers, were isolated from the seeds of Nigella glandulifera. Racemic 1 possesses a unique tricyclo[5.4.0.1(2,6)]dodecane carbon skeleton, and compounds 2 and 3 are two unusual diterpenoid alkaloids with indole cores. Their structures were determined by extensive spectroscopic analyses, and that of 1 was confirmed by single-crystal X-ray diffraction. Both (+)-1 and (-)-1 exhibited significant protective effects against hypoxia/reoxygenation-induced H9c2 myocardial cell injury...
November 17, 2017: Organic Letters
https://www.readbyqxmd.com/read/29148783/in-situ-assembly-of-nanoparticles-into-hierarchical-beta-zeolite-with-tailored-simple-organic-molecule
#14
Kai Zhang, Zewei Liu, Xin Yan, Xuelong Hao, Min Wang, Chao Li, Hongxia Xi
A hierarchically structured beta zeolite with intercrystalline mesopores was successfully synthesized via in situ assembly of nanoparticles by employing a simple organic molecule N2-p-N2, tailored form polyquaternium surfactant, with no hydrophobic long chain. The obtained material was characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), nitrogen adsorption/desorption isotherms and computer simulation. These results indicated that the tailored template molecule N2-p-N2 without hydrophobic long chain tail still can direct the zeolite crystallization, the hydrophobic long chain tail is not necessary during the mesoporous Beta zeolite formation...
November 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29148766/heterodimeric-diterpenoids-isolated-from-euphorbia-ebracteolata-roots-and-their-inhibitory-effects-on-%C3%AE-glucosidase
#15
Yunlong Wei, Chao Wang, Zhongbin Cheng, Xiangge Tian, Jingming Jia, Yonglei Cui, Lei Feng, Chengpeng Sun, Baojing Zhang, Xiaochi Ma
Two heterodimeric diterpenoids (1 and 2) comprising abietane lactone and nor-rosane constituent units were isolated from Euphorbia ebracteolata roots. Compound 1 exhibited a moderate inhibitory effect on α-glucosidase (IC50 = 7.94 μM), with a Ki value of 10.8 μM. In silico molecular docking has been performed to investigate the inhibition mechanism. Compound 2 inhibited the acetyl transfer activity of Mycobacterium tuberculosis GlmU (IC50 = 41.85 μM), which is a novel tuberculosis treatment target.
November 17, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29148706/porous-carbon-with-willow-leaf-shaped-pores-for-high-performance-supercapacitors
#16
Yanhong Shi, Lin-Lin Zhang, Tyler B Schon, Huan-Huan Li, Chao-Ying Fan, Xiao-Ying Li, Hai-Feng Wang, Xing-Long Wu, Haiming Xie, Haizhu Sun, Dwight S Seferos, Jingping Zhang
A novel kind of biomass-derived high oxygen containing carbon materials doped with nitrogen that have willow leaf shaped pores was synthesized. The obtained carbon materials have an exotic hierarchical pore structure composed of bowl shaped macropores, willow leaf shaped pores, and an abundance of micropores. This unique hierarchical porous structure provides an effective combination of high current densities with high capacitance due to a pseudocapacitive component that is afforded by the introduction of nitrogen and oxygen dopants...
November 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29148252/sex-hormone-binding-globulin-shbg-is-a-potential-early-diagnostic-biomarker-for-gastric-cancer
#17
Chao-Wen Cheng, Che-Chang Chang, Yudha Nur Patria, Ruei-Ting Chang, Yun-Ru Liu, Fu-An Li, Hsiu-Ming Shih, Ching-Yu Lin
The use of blood plasma biomarkers in gastric cancer (GC) management is limited due to a lack of reliable biomarkers. An LC-MS/MS assay and a bioinformatic analysis were performed to identify blood plasma biomarkers in a GC discovery cohort. The data obtained were verified and validated by western blotting and an ELISA in an independent study cohort. A label-free quantification analysis of the MS data using PEAKS7 software found that four plasma proteins of apolipoprotein C-1, gelsolin, sex hormone-binding globulin (SHBG), and complement component C4-A were significantly overexpressed in GC patients...
November 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29148054/transcriptome-analysis-unravels-an-ethylene-response-factor-involved-in-regulating-fruit-ripening-in-pear
#18
Ping-Ping Hao, Guo-Ming Wang, Hai-Yan Cheng, Ya-Qi Ke, Kai-Jie Qi, Chao Gu, Shao-Ling Zhang
Ethylene response factor (ERF) has been widely studied in regulating fruit ripening in tomato, apple, banana and kiwifruit, but little is known in pear. In this study 1-methylcyclopropene (1-MCP) treatment, an inhibitor of ethylene perception, was conducted at approximately 30 days before harvest to delay fruit ripening in a climacteric white pear cultivar Yali. Transcriptome libraries were constructed and sequenced in pre-ripening, ripening, and 1-MCP treated fruits. Data analysis showed that 73 candidate genes related to fruit ripening were induced by 1-MCP, among which two were positively related, namely 1-aminocyclopropane-1-carboxyla oxidase and an ERF gene (designated as ACO54 and ERF24)...
November 16, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/29148019/a-prospective-randomised-comparison-of-2-skin-closure-techniques-in-primary-total-hip-arthroplasty-surgery
#19
Min Rui, Xin Zheng, Shao-Song Sun, Cheng-Yu Li, Xing-Chen Zhang, Kai-Jin Guo, Feng-Chao Zhao, Yong Pang
INTRODUCTION: As an essential step of total hip arthroplasty (THA), an effective and secure skin closure technique after primary THA is important. Metallic staples closure and subcuticular suture are the 2 common techniques for skin closure. However, which closure technique is the optimal skin-closure method remains unclear. The purpose of this prospective randomised clinical study was to compare the clinical outcomes and costs between staples and subcuticular suture techniques. METHODS: In this clinical study, 165 patients who underwent primary unilateral THA through a posterolateral approach from August 2014 to May 2015 were included...
November 13, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29148014/unfavorable-clinical-implications-of-peripheral-blood-cd44-and-cd54-lymphocytes-in-patients-with-lung-cancer-undergoing-chemotherapy
#20
Zhuanbo Luo, Yun Wang, Yanru Lou, Chao Cao, Richard Hubbard, Ning Xu, Xiaoping Huang
BACKGROUND: There is an unmet need for identification of additional prognostic markers for lung cancer. The aim of this study was to identify novel clinical and immunological predictors of prognosis in lung cancer patients. METHODS: Lymphocyte subsets CD3+, CD4+, CD8+, CD4+/8+, CD25+, CD69+, CD44+ and CD54+ were quantified in peripheral blood using flow cytometry, for 203 newly diagnosed lung cancer patients and 120 healthy controls. RESULTS: The levels of CD3+, CD4+, CD8+, CD4+/CD8+ and CD69+ lymphocytes were significantly lower in patients with lung cancer compared with the healthy control group, while CD54+ and CD44+ lymphocytes were significantly higher...
November 15, 2017: International Journal of Biological Markers
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