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https://www.readbyqxmd.com/read/28437995/single-measurement-digital-optical-frequency-comb-based-phase-detection-brillouin-optical-time-domain-analyzer
#1
Chao Jin, Liang Wang, Yuli Chen, Nan Guo, Wenghong Chung, Hoyin Au, Zhaohui Li, Hwa-Yaw Tam, Chao Lu
A single-measurement sweep-free distributed Brillouin optical time domain analyzer (BOTDA) sensor based on phase detection is proposed and experimentally demonstrated employing digital optical frequency comb (DOFC) probe signal. Brillouin Phase Spectrum (BPS) of DOFC probe induced by Brillouin interaction is measured using coherent detection in a single acquisition, without any frequency scanning and data averaging. Single-measurement BOTDA sensor based on BPS in 10km long fiber is demonstrated with a response time of 100 μs, which is limited only by the fiber length...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437967/design-of-see-through-near-eye-display-for-presbyopia
#2
Yishi Wu, Chao Ping Chen, Lei Zhou, Yang Li, Bing Yu, Huayi Jin
We propose a compact design of see-through near-eye display that is dedicated to presbyopia. Our solution is characterized by a plano-convex waveguide, which is essentially an integration of a corrective lens and two volume holograms. Its design rules are set forth in detail, followed by the results and discussion regarding the diffraction efficiency, field of view, modulation transfer function, distortion, and simulated imaging.
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437966/energy-scaling-and-extended-tunability-of-terahertz-wave-parametric-oscillator-with-mgo-doped-near-stoichiometric-linbo-sub-3-sub-crystal
#3
Yuye Wang, Longhuang Tang, Degang Xu, Chao Yan, Yixin He, Jia Shi, Dexian Yan, Hongxiang Liu, Meitong Nie, Jiachen Feng, Jianquan Yao
A widely tunable, high-energy terahertz wave parametric oscillator based on 1 mol. % MgO-doped near-stoichiometric LiNbO<sub>3</sub> crystal has been demonstrated with 1064 nm nanosecond pulsed laser pumping. The tunable range of 1.16 to 4.64 THz was achieved. The maximum THz wave output energy of 17.49 μJ was obtained at 1.88 THz under the pump energy of 165 mJ/pulse, corresponding to the THz wave conversion efficiency of 1.06 × 10<sup>-4</sup> and the photon conversion efficiency of 1...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437949/ultrafast-all-optical-solid-state-framing-camera-with-picosecond-temporal-resolution
#4
Guilong Gao, Kai He, Jinshou Tian, Chunmin Zhang, Jun Zhang, Tao Wang, Shaorong Chen, Hui Jia, Fenfang Yuan, Lingliang Liang, Xin Yan, Shaohui Li, Chao Wang, Fei Yin
A new ultrafast all-optical solid-state framing camera (UASFC) capable of single-shot ultrafast imaging is proposed and experimentally demonstrated. It is composed of an ultrafast semiconductor chip (USC), an optical time-series system (TSS), and a spatial mapping device (SMD) with an USC to transform signal beam information to the probe beam, a TSS to convert the time axis to wavelength-polarization, and a SMD to map wavelength-polarization image to different spatial positions. In our recent proof-of-principle experiment, better performance than ever of this technique is confirmed by giving six frames with ~3 ps temporal resolution and ~30 lp/mm spatial resolution...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437633/microrna-500a-promotes-migration-and-invasion-in-hepatocellular-carcinoma-by-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#5
Yuntao Guo, Liwen Chen, Chengyi Sun, Chao Yu
Increased expression of microRNA-500a (miR-500a) has been reported in the serum of hepatocellular carcinoma (HCC) patients. However, the biological effects and mechanisms of miR-500a in hepatoma cells remain unclear. In this study, we found that miR-500a expression was up-regulated in HCC cell lines and tissues, and that high levels of miR-500a was associated with poor prognosis. We found that miR-500a upregulation promoted migration and invasion in two hepatoma cell lines, HCCLM3 and SMMC7721, while miR-500a downregulation had the opposite effect...
April 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28437612/combinatorial-library-based-on-restriction-enzyme-mediated-modular-assembly
#6
Cuiping Ma, Chao Liang, Yifan Wang, Mei Pan, Qianqian Jiang, Chao Shi
Combinatorial approaches in directed evolution were proven to be more efficient for exploring sequence space and innovating the function of protein. We presented modular assembly of secondary structures (MASS) for constructing a combinatorial library. In this approach, secondary structure elements were extracted from natural existing proteins, the common linkers were flanking secondary structure elements, then digested by Hinf I restriction endonuclease that was used in the construction of combinatorial library for the first time...
April 24, 2017: ACS Combinatorial Science
https://www.readbyqxmd.com/read/28437248/protective-effect-of-calretinin-on-testicular-leydig-cells-via-the-inhibition-of-apoptosis
#7
Wendan Xu, Qian Zhu, Bei Zhang, Shan Liu, Xiaonan Dai, Chao Gao, Li Gao, Yugui Cui
The core mechanism of Late-onset hypogonadism (LOH) is the deficiency of androgen due to the functional and quantitative decline of testicular Leydig cells. Here we explored the protective effect of calretinin, a Ca(2+)-binding protein, on Leydig cells. We found in MLTC-1 cells transfected with LV-calb2, the cell viability and optical density (OD) were higher (p<0.05), cells in the S phase of the cell cycle were increased (p<0.01) and p-ERK1/2 and p-AKT levels were significantly higher (p<0.01 and p<0...
April 24, 2017: Aging
https://www.readbyqxmd.com/read/28436864/tracking-based-multi-orientation-scene-text-detection-a-unified-framework-with-dynamic-programming
#8
Chun Yang, Xu-Cheng Yin, Wei-Yi Pei, Shu Tian, Ze-Yu Zuo, Chao Zhu, Junchi Yan
There are a variety of grand challenges for multiorientation text detection in scene videos, where the typical issues include skew distortion, low contrast and arbitrary motion. Most conventional video text detection methods using individual frames have limited performance. In this paper, we propose a novel tracking based multi-orientation scene text detection method using multiple frames within a unified framework via dynamic programming. First, a multi-information fusion based multiorientation text detection method in each frame is proposed to extensively locate possible character candidates and extract text regions with multiple channels and scales...
April 18, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28436853/automatic-skin-lesion-segmentation-using-deep-fully-convolutional-networks-with-jaccard-distance
#9
Yading Yuan, Ming Chao, Yeh-Chi Lo
Automatic skin lesion segmentation in dermoscopic images is a challenging task due to the low contrast between lesion and the surrounding skin, the irregular and fuzzy lesion borders, the existence of various artifacts, and various imaging acquisition conditions. In this article, we present a fully automatic method for skin lesion segmentation by leveraging a 19-layer deep convolutional neural networks (CNNs) that is trained end-to- end and does not rely on prior knowledge of the data. We propose a set of strategies to ensure effective and efficient learning with limited training data...
April 18, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28436734/effects-of-speed-control-measures-on-the-safety-of-unsignalized-mid-block-street-crossings-in-china
#10
Chao Wang, Zhirui Ye, Xinyi Wang, Wenting Li
OBJECTIVE: The primary objective of this study was to evaluate the effects of different speed control measures on the safety of unsignalized mid-block street crossings. METHODS: In China, it is quite difficult to obtain traffic crash and conflict data for pedestrians using such crossings, mainly due to the lack of traffic data management and organizational issues. In light of this, the proposed method did not rely on such data, but considered vehicle speed, which is a leading contributing factor of pedestrian safety at mid-blocks...
February 16, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28436658/chemical-composition-and-acetylcholinesterase-inhibitory-activity-of-essential-oils-from-piper-species
#11
Cai-Peng Xiang, Jia-Xin Han, Xing-Cong Li, Yun-Hui Li, Yi Zhang, Lin Chen, Yan Qu, Chao-Yun Hao, Hai-Zhou Li, Chong-Ren Yang, San-Jun Zhao, Min Xu
The essential oils (EOs) derived from aromatic plants such as Piper species are considered to play a role in alleviating neuronal ailments that are associated with inhibition of acetylcholinesterase (AChE). The chemical compositions of 23 EOs prepared from 16 Piper spp. were analyzed by both gas chromatography with aflame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). A total of 76 compounds were identified in the EOs from the leaves and stems of 19 samples, while 30 compounds were detected in the EOs from the fruits of four samples...
April 24, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28436581/pediatric-acute-lymphoblastic-leukemia-with-t-1-19-tcf3-pbx1-in-taiwan
#12
Hsiu-Ju Yen, Shih-Hsiang Chen, Tsung-Yen Chang, Chao-Ping Yang, Dong-Tsamn Lin, Iou-Jih Hung, Kai-Hsin Lin, Jiann-Shiuh Chen, Chih-Cheng Hsiao, Tai-Tsung Chang, Te-Kao Chang, Ching-Tien Peng, Ming-Tsan Lin, Tang-Her Jaing, Hsi-Che Liu, Shiann-Tarng Jou, Meng-Yao Lu, Chao-Neng Cheng, Jiunn-Ming Sheen, Shyh-Shin Chiou, Giun-Yi Hung, Kang-Hsi Wu, Ting-Chi Yeh, Shih-Chung Wang, Rong-Long Chen, Hsiu-Hao Chang, Yung-Li Yang, Shu-Huey Chen, Shin-Nan Cheng, Yu-Hsiang Chang, Bow-Wen Chen, Yuh-Lin Hsieh, Fang-Liang Huang, Wan-Ling Ho, Jinn-Li Wang, Chia-Yau Chang, Yu-Hua Chao, Pei-Chin Lin, Yu-Chieh Chen, Yu-Mei Liao, Tung-Huei Lin, Lee-Yung Shih, Der-Cherng Liang
BACKGROUND: In childhood acute lymphoblastic leukemia (ALL), t(1;19)(q23;p13.3) with TCF3-PBX1 fusion is one of the most frequent translocations. Historically, it has been associated with poor prognosis. Intensive treatment, however, has improved its outcome. We determined the outcome of children with this genotype treated with contemporary intensive chemotherapy in Taiwan. PROCEDURE: In Taiwan Pediatric Oncology Group 2002 ALL studies, genotypes were determined by cytogenetic analysis and/or reverse transcriptase polymerase chain reaction assay...
April 24, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28436566/atrial-fibrillation-originating-from-superior-vena-cava-with-atrial-flutter-electrocardiogram-pattern
#13
Hung-Kai Huang, Shih-Lin Chang, Yenn-Jiang Lin, Li-Wei Lo, Yu-Feng Hu, Fa-Po Chung, Yen-Chang Huang, Chung-Hsing Lin, Chao-Shun Chan, Hung-Yu Chang, Chin-Yu Lin, Yao-Ting Chang, Ching-Hui Huang, Shih-Ann Chen
BACKGROUNDS: Substrate property is related to the genesis and maintenance of atrial fibrillation (AF). The aim of the study was to investigate the impact of substrate property on the electrocardiogram (ECG) in patients with AF originating from the superior vena cava (SVC). METHODS AND RESULTS: Seventy-six patients with AF originating from SVC underwent catheter ablation were included from 2004 to 2013. Of these patients, 16 had a presentation of atrial flutter (AFL)-pattern ECG during AF (group 1), and 60 patients did not (group 2)...
April 24, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28436454/gold-nanoparticle-polymer-nanocomposites-synthesized-by-room-temperature-atmospheric-pressure-plasma-and-their-potential-for-fuel-cell-electrocatalytic-application
#14
Ri-Chao Zhang, Dan Sun, Ruirui Zhang, Wen-Feng Lin, Manuel Macias-Montero, Jenish Patel, Sadegh Askari, Calum McDonald, Davide Mariotti, Paul Maguire
Conductive polymers have been increasingly used as fuel cell catalyst support due to their electrical conductivity, large surface areas and stability. The incorporation of metal nanoparticles into a polymer matrix can effectively increase the specific surface area of these materials and hence improve the catalytic efficiency. In this work, a nanoparticle loaded conductive polymer nanocomposite was obtained by a one-step synthesis approach based on room temperature direct current plasma-liquid interaction. Gold nanoparticles were directly synthesized from HAuCl4 precursor in poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS)...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28435976/-role-of-igg-plasma-cells-in-the-change-of-protein-c-system-in-ulcerative-colitis
#15
Xu-Hong Lin, Jun-Ling Guo, Yu-Qing Wen, Yu-Xia Li, Dan-Dan Wei, Rui-Lin Yang, Xiao-Yun Mu, Hui-Chao Wang
The present study is designed to explore the role of plasma cells in the change of protein C system (PCS) in ulcerative colitis (UC). Dextran sulfate sodium (DSS, 4% in concentration) was used to induce mouse UC model. The plasma cells and the type of immune complex in colon were observed by immunofluorescence. The amount and type of plasma cells separated from colonic mucosal lamina propria were detected by flow cytometry using anti-CD54(+)CD38(+) and IgA/M/G antibodies, respectively. After stimulation of macrophages by IgG type immune complex, TNF-α and IL-6 levels were evaluated by ELISA...
April 25, 2017: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/28435869/a-dynamic-hydrophobic-core-orchestrates-allostery-in-protein-kinases
#16
Jonggul Kim, Lalima G Ahuja, Fa-An Chao, Youlin Xia, Christopher L McClendon, Alexandr P Kornev, Susan S Taylor, Gianluigi Veglia
Eukaryotic protein kinases (EPKs) constitute a class of allosteric switches that mediate a myriad of signaling events. It has been postulated that EPKs' active and inactive states depend on the structural architecture of their hydrophobic cores, organized around two highly conserved spines: C-spine and R-spine. How the spines orchestrate the transition of the enzyme between catalytically uncommitted and committed states remains elusive. Using relaxation dispersion nuclear magnetic resonance spectroscopy, we found that the hydrophobic core of the catalytic subunit of protein kinase A, a prototypical and ubiquitous EPK, moves synchronously to poise the C subunit for catalysis in response to binding adenosine 5'-triphosphate...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28435772/self-assembled-bifunctional-peptide-as-effective-drug-delivery-vector-with-powerful-antitumor-activity
#17
Rangrang Fan, Lan Mei, Xiang Gao, Yuelong Wang, Mingli Xiang, Yu Zheng, Aiping Tong, Xiaoning Zhang, Bo Han, Liangxue Zhou, Peng Mi, Chao You, Zhiyong Qian, Yuquan Wei, Gang Guo
E-cadherin/catenin complex is crucial for cancer cell migration and invasion. The histidine-alanine-valine (HAV) sequence has been shown to inhibit a variety of cadherin-based functions. In this study, by fusing HAV and the classical tumor-targeting Arg-Gly-Asp (RGD) motif and Asn-Gly-Arg (NGR) motif to the apoptosis-inducing peptide sequence-AVPIAQK, a bifunctional peptide has been constructed with enhanced tumor targeting and apoptosis effects. This peptide is further processed as a nanoscale vector to encapsulate the hydrophobic drug docetaxel (DOC)...
April 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28435523/discovery-of-1-2-3-triazolo-4-5-d-pyrimidine-derivatives-as-novel-lsd1-inhibitors
#18
Zhong-Hua Li, Xue-Qi Liu, Peng-Fei Geng, Feng-Zhi Suo, Jin-Lian Ma, Bin Yu, Tao-Qian Zhao, Zhao-Qing Zhou, Chen-Xi Huang, Yi-Chao Zheng, Hong-Min Liu
Lysine specific demethylase 1 (LSD1) plays a pivotal role in regulating the lysine methylation. The aberrant overexpression of LSD1 has been reported to be involved in the progression of certain human malignant tumors. Abrogation of LSD1 with RNAi or small molecule inhibitors may lead to the inhibition of cancer proliferation and migration. Herein, a series of [1,2,3]triazolo[4,5-d]pyrimidine derivatives were synthesized and evaluated for their LSD1 inhibitory effects. The structure-activity relationship studies (SARs) were conducted by exploring three regions of this scaffold, leading to the discovery of compound 27 as potent LSD1 inhibitor (IC50 = 0...
April 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28435251/comparative-study-of-porous-hydroxyapatite-chitosan-and-whitlockite-chitosan-scaffolds-for-bone-regeneration-in-calvarial-defects
#19
Ding Zhou, Chao Qi, Yi-Xuan Chen, Ying-Jie Zhu, Tuan-Wei Sun, Feng Chen, Chang-Qing Zhang
Hydroxyapatite (HAP; Ca10(PO4)6(OH)2) and whitlockite (WH; Ca18Mg2(HPO4)2(PO4)12) are widely utilized in bone repair because they are the main components of hard tissues such as bones and teeth. In this paper, we synthesized HAP and WH hollow microspheres by using creatine phosphate disodium salt as an organic phosphorus source in aqueous solution through microwave-assisted hydrothermal method. Then, we prepared HAP/chitosan and WH/chitosan composite membranes to evaluate their biocompatibility in vitro and prepared porous HAP/chitosan and WH/chitosan scaffolds by freeze drying to compare their effects on bone regeneration in calvarial defects in a rat model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28435178/chaotic-experiences-and-low-income-children-s-social-emotional-development
#20
Kaeley C Bobbitt, Elizabeth T Gershoff
Development in early childhood is increasingly likely to take place in multiple contexts. Continuity and discontinuity in children's experiences across multiple contexts have important implications for their development. This study examines the extent to which children experience chaos in their homes and in their preschool settings is linked with their social-emotional development over the course of the preschool year. Data from a large, representative sample of low-income preschool children attending Head Start was used to test a series of multi-level models...
November 2016: Children and Youth Services Review
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