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Fractional excretion urea

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https://www.readbyqxmd.com/read/28078852/cell-based-therapies-for-experimental-diabetic-nephropathy-a-systematic-review-and-meta-analysis
#1
H J Tang, Z G Tian, X Yang, Y Cao, W G Li
Study has shown that stem cell–based therapies are promising strategies in the treatment of several chronic diseases, but their overall benefit in the treatment of diabetic nephropathy (DN) remains controversial. The purpose of this study is to summarize the evidence of the effect of cell-based therapy in the treatment of DN to guide future clinical trials. We searched PubMed, EmBase, and the Cochrane Library for studies from the inception of cell-based therapies up to July 2015. We included animal trials that reported the effects of cell-based therapy on kidney function, cardiovascular risk factors, and body factors...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28069102/the-effect-of-cp-concentration-in-the-diet-on-urea-kinetics-and-microbial-usage-of-recycled-urea-in-cattle-a-meta-analysis
#2
E D Batista, E Detmann, S C Valadares Filho, E C Titgemeyer, R F D Valadares
In ruminants, urea recycling is considered an evolutionary advantage. The amount of urea recycled mainly depends of the nitrogen (N) intake and the amount of organic matter (OM) digested in the rumen. Because recycled N contributes to meeting microbial N requirements, accurate estimates of urea recycling can improve the understanding of efficiency of N utilization and N losses to the environment. The objective of this study was to evaluate urea kinetics and microbial usage of recycled urea N in ruminants using a meta-analytical approach...
January 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28040487/a-waterborne-chemical-cue-from-gulf-toadfish-opsanus-beta-prompts-pulsatile-urea-excretion-in-conspecifics
#3
Jeremy Fulton, Christophe M R LeMoine, Carol Bucking, Kevin V Brix, Patrick J Walsh, M Danielle McDonald
The Gulf toadfish (Opsanus beta) has a fully functional ornithine urea cycle (O-UC) that allows it to excrete nitrogenous waste in the form of urea. Interestingly, urea is excreted in a pulse across the gill that lasts 1-3h and occurs once or twice a day. Both the stress hormone, cortisol, and the neurotransmitter, serotonin (5-HT) are involved in the control of pulsatile urea excretion. This and other evidence suggests that urea pulsing may be linked to toadfish social behavior. The hypothesis of the present study was that toadfish urea pulses can be triggered by waterborne chemical cues from conspecifics...
December 28, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/28013356/diuretic-effect-of-extracts-fractions-and-two-compounds-2%C3%AE-3%C3%AE-19%C3%AE-trihydroxy-urs-12-en-28-oic-acid-and-5-hydroxy-3-6-7-8-4-pentamethoxyflavone-from-rubus-rosaefolius-sm-rosaceae-leaves-in-rats
#4
Priscila de Souza, Thaise Boeing, Lincon Bordignon Somensi, Camile Cecconi Cechinel-Zanchett, Jairo Kenupp Bastos, Marcel Petreanu, Rivaldo Niero, Valdir Cechinel-Filho, Luisa Mota da Silva, Sérgio Faloni de Andrade
Although diuretics have been widely used to treat hypertension along with others cardiovascular and renal disorders, no scientific data have been recorded to support the diuretic properties of Rubus rosaefolius Sm. (Rosaceae), a plant popularly used in Brazil to treat hypertension. Male Wistar rats were orally treated with: vehicle; hydrochlorothiazide; aqueous (AERR) and methanolic (MERR) extracts; dichloromethane (DCM), hexane (HEX) and ethyl acetate (EA) fractions; and the isolated compounds 2α,3β,19α-trihydroxy-urs-12-en-28-oic acid (TUA) and 5-hydroxy-3,6,7,8,4'-pentamethoxyflavone (PMF)...
December 24, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27751996/fractional-excretion-of-magnesium-a-marker-of-aminoglycoside-induced-nephrotoxicity-in-neonates
#5
Sheikh Farjana Sonia, Mohammad S Hassan, Ferdous Ara, Mohammed Hanif
Aminoglycoside is a widely used antibiotic in neonatal age group at hospital setting in Bangladesh. It has underlying side effect and toxicity which is mostly unseen and ignored. The aim of the study was to evaluate the nephrotoxic effect of aminoglycoside in neonates. This study was conducted in fifty hospital admitted neonates of Dhaka Shishu Hospital from January 2012 to December 2013. Serum creatinine, blood urea nitrogen, and fractional excretion of magnesium (FEMg) were measured before starting and after seven days of aminoglycoside treatment...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27624603/the-effect-of-tolvaptan-on-renal-excretion-of-electrolytes-and-urea-nitrogen-in-patients-undergoing-coronary-artery-bypass-surgery
#6
Tomoko S Kato, Hiroshi Nakamura, Mai Murata, Kishio Kuroda, Hitoshi Suzuki, Yasutaka Yokoyama, Akie Shimada, Satoshi Matsushita, Taira Yamamoto, Atsushi Amano
BACKGROUND: Adequate fluid management is an important component of patient care following cardiac surgery. Our aim in this study was to determine the benefits of tolvaptan, an oral selective vasopressin-2 receptor antagonist that causes electrolyte-free water diuresis, in postoperative fluid management. We prospectively examined the effect of tolvaptan on renal excretion of electrolytes and urea nitrogen in cardiac surgery patients. METHODS: Patients undergoing coronary artery bypass surgery were randomized to receive conventional loop diuretics (Group C, n = 30) or conventional loop diuretic therapy plus tolvaptan (Group T, n = 27)...
2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27585605/renal-effects-of-dpp-4-inhibitor-sitagliptin-or-glp-1-receptor-agonist-liraglutide-in-overweight-patients-with-type-2-diabetes-a-12-week-randomized-double-blind-placebo-controlled-trial
#7
Lennart Tonneijck, Mark M Smits, Marcel H A Muskiet, Trynke Hoekstra, Mark H H Kramer, A H Jan Danser, Piet M Ter Wee, Michaela Diamant, Jaap A Joles, Daniël H van Raalte
OBJECTIVE: To investigate effects of dipeptidyl peptidase-4 inhibitor (DPP-4I) sitagliptin or glucagon-like peptide 1 (GLP-1) receptor agonist liraglutide treatment on renal hemodynamics, tubular functions, and markers of renal damage in overweight patients with type 2 diabetes without chronic kidney disease (CKD). RESEARCH DESIGN AND METHODS: In this 12-week, randomized, double-blind trial, 55 insulin-naïve patients with type 2 diabetes (mean ± SEM: age 63 ± 7 years, BMI 31...
November 2016: Diabetes Care
https://www.readbyqxmd.com/read/27522260/astilbin-improves-potassium-oxonate-induced-hyperuricemia-and-kidney-injury-through-regulating-oxidative-stress-and-inflammation-response-in-mice
#8
Ming Wang, Jing Zhao, Nan Zhang, Jianghua Chen
Astilbin is a flavonoid compound derived from the rhizome of Smilax china L. The effects and possible molecular mechanisms of astilbin on potassium oxonate-induced hyperuricemia mice were investigated in this study. Different dosages of astilbin (5, 10, and 20mg/kg) were administered to induce hyperuricemic mice. The results demonstrated that the serum uric acid (Sur) level was significantly decreased by increasing the urinary uric acid (Uur) level and fractional excretion of urate (FEUA) with astilbin, related with suppressing role in meditation of Glucose transporter 9 (GLUT9), Human urate transporter 1 (URAT1) expression and up-regulation of ABCG2, Organic anion transporter 1/3 (OAT1/3) and Organic cation transporter 1 (OCT1)...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27507200/siwu-decoction-attenuates-oxonate-induced-hyperuricemia-and-kidney-inflammation-in-mice
#9
Rong Wang, Chun-Hua Ma, Fan Zhou, Ling-Dong Kong
The aim of the study was to investigate the effects of Siwu decoction on hyperuricemia, kidney inflammation, and dysfunction in hyperuricemic mice. Siwu decoction at 363.8, 727.5, and 1 455 mg·kg(-1) was orally administered to potassium oxonate-induced hyperuricemic mice for 7 days. Serum urate, creatinine, and blood urea nitrogen levels and hepatic xanthine oxidase (XOD) activity were measured. The protein levels of hepatic XOD and renal urate transporter 1 (URAT1), glucose transporter 9 (GLUT9), organic anion transporters 1 (OAT1), ATP-binding cassette subfamily G member 2 (ABCG2), organic cation transporter 1 (OCT1), OCT2, organic cation/carnitine transporter 1 (OCTN1), OCNT2, Nod-like receptor family, pyrin domain containing 3 (NLRP3), apoptosis-associated speck-like protein (ASC), Caspase-1, and interleukin-1β (IL-1β) were determined by Western blotting...
July 2016: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/27484883/curcumin-alleviates-ischemia-reperfusion-induced-acute-kidney-injury-through-nmda-receptor-antagonism-in-rats
#10
Anudeep Kaur, Tajpreet Kaur, Balbir Singh, Devendra Pathak, Harpal Singh Buttar, Amrit Pal Singh
OBJECTIVE: The present study investigated the role of N-methyl-d-aspartate (NMDA) receptors in curcumin-mediated renoprotection against ischemia reperfusion (I/R)-induced acute kidney injury (AKI) in rats. METHODS: Rats were subjected to bilateral renal I/R (40 min I, 24 hours R) to induce AKI. Kidney injury was assessed by measuring creatinine clearance, blood urea nitrogen, plasma uric acid, potassium level, fractional excretion of sodium, and macroproteinuria...
October 2016: Renal Failure
https://www.readbyqxmd.com/read/27466783/conjugated-linoleic-acid-rat-pretreatment-reduces-renal-damage-in-ischemia-reperfusion-injury-unraveling-antiapoptotic-mechanisms-and-regulation-of-phosphorylated-mammalian-target-of-rapamycin
#11
Gholamali Javedan, Farzad Shidfar, Sayed Hossein Davoodi, Marjan Ajami, Fazel Gorjipour, Antoni Sureda, Seyed Mohammad Nabavi, Maria Daglia, Hamidreza Pazoki-Toroudi
SCOPE: Conjugated linoleic acids (CLAs) are dietary components with beneficial effects on human health. The aim of this study was to evaluate the potential benefits of CLA pretreatment in a rat model of renal ischemia/reperfusion injury (IRI). METHODS AND RESULTS: Animals were treated with CLAs (200 mg/kg/day) or water for two weeks prior to sham surgery or to surgery to induce IRI. Renal function, oxidative stress, apoptosis, and cell proliferation markers, were evaluated...
December 2016: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/27448107/molecular-hydrogen-in-human-breath-a-new-strategy-for-selectively-diagnosing-peptic-ulcer-disease-non-ulcerous-dyspepsia-and-helicobacter-pylori-infection
#12
Abhijit Maity, Mithun Pal, Sanchi Maithani, Barnali Ghosh, Sujit Chaudhuri, Manik Pradhan
The gastric pathogen Helicobacter pylori utilizes molecular hydrogen (H2) as a respiratory substrate during colonization in the gastric mucosa. However, the link between molecular H2 and the pathogenesis of peptic-ulcer disease (PUD) and non-ulcerous dyspepsia (NUD) by the enzymatic activity of H. pylori still remains mostly unknown. Here we provide evidence that breath H2 excretion profiles are distinctly altered by the enzymatic activity of H. pylori for individuals with NUD and PUD. We subsequently unravelled the potential molecular mechanisms responsible for the alteration of H2 in exhaled breath in association with peptic ulcers, encompassing both gastric and duodenal ulcers, along with NUD...
2016: Journal of Breath Research
https://www.readbyqxmd.com/read/27336410/stim1fl-fl-ksp-cre-mouse-has-impaired-renal-water-balance
#13
Liudmila Cebotaru, Valeriu Cebotaru, Hua Wang, Lois J Arend, William B Guggino
BACKGROUND/AIM: STIM1 is as an essential component in store operated Ca2+ entry. However give the paucity of information on the role of STIM1 in kidney, the aim was to study the function of STIM1 in the medulla of the kidney. METHODS: we crossed a Ksp-cre mouse with another mouse containing two loxP sites flanking Exon 6 of STIM1. The Ksp-cre mouse is based upon the Ksp-cadherin gene promoter which expresses cre recombinase in developing nephrons, collecting ducts (SD) and thick ascending limbs (TAL) of the loop of Henle...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27289795/fractional-excretion-of-sodium-and-fractional-excretion-of-urea-in-differentiating-prerenal-from-renal-azotemia-complicating-circulatory-shock
#14
H M Sherif, A R Yassin, A Y Mousa, A Esmat
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27236480/urine-sodium-concentration-to-predict-fluid-responsiveness-in-oliguric-icu-patients-a-prospective-multicenter-observational-study
#15
MULTICENTER STUDY
Matthieu Legrand, Brigitte Le Cam, Sébastien Perbet, Claire Roger, Michael Darmon, Philippe Guerci, Axelle Ferry, Véronique Maurel, Sabri Soussi, Jean-Michel Constantin, Etienne Gayat, Jean-Yves Lefrant, Marc Leone
BACKGROUND: Oliguria is one of the leading triggers of fluid loading in patients in the intensive care unit (ICU). The purpose of this study was to assess the predictive value of urine Na(+) (uNa(+)) and other routine urine biomarkers for cardiac fluid responsiveness in oliguric ICU patients. METHODS: We conducted a prospective multicenter observational study in five university ICUs. Patients with urine output (UO) <0.5 ml/kg/h for 3 consecutive hours with a mean arterial pressure >65 mmHg received a fluid challenge...
May 29, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27101843/simple-blood-and-urinary-parameters-measured-at-icu-admission-may-sign-for-aki-development-in-the-early-postoperative-period-a-retrospective-exploratory-study
#16
Alexandre Toledo Maciel, Lia Delphino Salles, Daniel Vitorio
Recent studies have suggested that some blood physicochemical and urinary biochemical parameters have a standardized behavior during acute kidney injury (AKI) development. The changes in these parameters frequently begin to occur before significant rises in serum creatinine (sCr) and may help in identifying patients with more subtle decreases in glomerular filtration rate (GFR). Surgical patients have an increased risk of AKI but renal impairment is usually not evident at ICU admission. We hypothesized that the surgical patients who have AKI diagnosed in the early postoperative period have an impaired GFR since ICU admission, indirectly inferred by alterations in these blood physicochemical and urinary biochemical parameters even in the presence of a still normal sCr...
November 2016: Renal Failure
https://www.readbyqxmd.com/read/27038451/acute-renal-effects-of-the-glp-1-receptor-agonist-exenatide-in-overweight-type-2-diabetes-patients-a-randomised-double-blind-placebo-controlled-trial
#17
Lennart Tonneijck, Mark M Smits, Marcel H A Muskiet, Trynke Hoekstra, Mark H H Kramer, A H Jan Danser, Michaela Diamant, Jaap A Joles, Daniël H van Raalte
AIMS/HYPOTHESIS: This study aimed to investigate the acute renal effects of the glucagon-like peptide-1 receptor agonist (GLP-1RA) exenatide in type 2 diabetes patients. METHODS: We included overweight (BMI 25-40 kg/m(2)) men and postmenopausal women, aged 35-75 years with type 2 diabetes (HbA1c 48-75 mmol/mol; 6.5-9.0%) and estimated GFR ≥ 60 ml min(-1) 1.73 m(-2). Exenatide or placebo (NaCl solution, 154 mmol/l) was administrated intravenously in an acute, randomised, double-blind, placebo-controlled trial conducted at the Diabetes Center VU University Medical Center (VUMC)...
July 2016: Diabetologia
https://www.readbyqxmd.com/read/27021008/angiotensin-ii-type-2-receptor-agonist-c21-reduces-proteinuria-and-oxidative-stress-in-kidney-of-high-salt-fed-obese-zucker-rats
#18
COMPARATIVE STUDY
Sanket N Patel, Quaisar Ali, Tahir Hussain
Oxidative and nitrosative stress have been implicated in high-sodium diet (HSD)-related hypertensive renal injury. In this study, we investigated angiotensin II type 2-receptor-mediated renoprotection in obese Zucker rats fed HSD. Obese Zucker rats were fed normal sodium diet or HSD 4%, for 14 days, with/without angiotensin II type 2-receptor agonist C21, delivered subcutaneously via osmotic pump, 1 mg/kg per day. Compared with normal sodium diet controls, HSD rats exhibited increase in cortical nicotinamide adenine dinucleotide phosphate oxidase activity, urinary H2O2, and 8-isoprostanes, which were associated with severe glomerulosclerosis, interstitial fibrosis, decline in estimated glomerular filtration rate, and an increase in urinary leak and activity of N-acetyl-β-D-glucosaminidase, a lysosomal enzyme and a marker of tubular damage...
May 2016: Hypertension
https://www.readbyqxmd.com/read/27001938/-development-and-basics-of-metabolic-monitoring-in-dairy-cows-focus-on-research-in-eastern-germany-and-at-the-university-of-leipzig-germany
#19
M Fürll
UNLABELLED: Systematic metabolic monitoring began in German-speaking countries in the late 1960s, early 1970s, due to an increase in metabolic disorders as a cause of infertility and mastitis and aimed at their prevention through early diagnosis. Development of a unified monitoring standard: Initiated by Rossow, Gürtler, Ehrentraut, Seidel and Furcht a standard "metabolic monitoring in cattle production" was developed in the 1970s. It included farm analysis, clinical and biochemical controls, prophylaxis and follow-up controls...
2016: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/26993815/utility-of-fractional-excretion-of-urea-in-the-differential-diagnosis-of-acute-kidney-injury-in-children
#20
Hisayo Fujita, Masayoshi Shinjoh, Tomohiro Ishii, Midori Awazu
INTRODUCTION: The fractional excretion of sodium (FENa) has been used as an index for the differential diagnosis of acute tubular necrosis (ATN) and prerenal acute kidney injury (AKI). The reliability of this index, however, decreases with the use of the diuretic agent furosemide. The fractional excretion of urea nitrogen (FEUN) has been shown to be useful in such settings in adults. The objective of this study was to examine whether FEUN is also useful in these settings in children. METHODS: We assessed 102 episodes of AKI in 74 children, classifying these into three groups based on history, physical examination, urine examination and subsequent clinical course: (1) prerenal AKI without furosemide (N = 37), (2) prerenal AKI with furosemide (N = 32) and (3) ATN (N = 33)...
August 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
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