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https://www.readbyqxmd.com/read/27865869/erk-potentiates-p38-in-central-sensitization-induced-by-traumatic-occlusion
#1
Lei Jing, Xiao-Dong Liu, Hong-Xu Yang, Mian Zhang, Ying Wang, Li Duan, Jing Zhang, Lei Lu, Ting Yang, Dong-Mei Wang, Liang-Wei Chen, Mei-Qing Wang
This study was to investigate the role of p38 activation via ERK1/2 phosphorylation in neurons and microglia of the spinal trigeminal subnucleus caudalis (Vc) in the promotion of orofacial hyperalgesia induced by unilateral anterior crossbite (UAC) traumatic occlusion in adult rats. U0126, a p-ERK1/2 inhibitor, was injected intracisternally before UAC implant. The effects of the U0126 injection were compared to those following the injection of SB203580, a p-p38 inhibitor. Mechanical hyperalgesia was evaluated via pressure pain threshold measurements...
November 16, 2016: Neuroscience
https://www.readbyqxmd.com/read/24217022/stereotactic-neurosurgical-technique-and-electrophysiological-study-in-ablating-the-ventromedial-shell-of-the-nucleus-accumbens
#2
Kai-jun Yang, Hao Long, Ya-wei Yuan, Song-tao Qi, Bo-tao Xu, Ke-wan Wang, Ye Song
OBJECTIVE: To describe in as much detail as possible the method for ablating the ventromedial shell of the nucleus accumbens (NAc) and investigate the efficacy and safety of the ablation treatment. METHODS: Sixty-five patients with drug addictions received operations within the time frame from 2004 to 2009. The ablation targets were located in the bilateral medial posterior inferior shell of the NAc. Intraoperative electrophysiological monitoring was performed. RESULTS: Tissue impedance in the shell of the NAc varied from 185 to 355 Ω...
2014: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/24120144/reassessment-of-scoring-systems-and-prognostic-factors-for-metastatic-spinal-cord-compression
#3
Emeline Tabouret, Cécile Cauvin, Stéphane Fuentes, Benjamin Esterni, Tarek Adetchessi, Naji Salem, Anne Madroszyk, Anthony Gonçalves, François Casalonga, Gwenaelle Gravis
BACKGROUND CONTEXT: The incidence of metastatic spinal cord compression (MSCC) is increasing, paralleling increasing life expectancy of patients. However, management of MSCC and relevance of scoring systems remain controversial. PURPOSE: The aims of our study were to analyze the feasibility and outcomes of spinal surgery, to identify prognostic factors for survival, and to assess the accuracy of scoring systems in patients with malignancies associated with MSCC...
May 1, 2015: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/23662410/-the-role-of-ho-co-in-the-spinal-nociception-transmission-and-hyperalgesia-of-rats-induced-by-formalin
#4
Hui-Na Li, Li-Hua Guo, Qing-Jun Li, Lei Liu
OBJECTIVE: To investigate the role of heme oxygenase and carbon monoxide (HO/CO) in the development of spontaneous pain and hyperalgesia of rats induced by formalin injection. METHODS: Zinc protoporphyrin Znpp (the inhibitor of HO) was intrathecally injected to the rats with formalin inflammatory pain. Hemin (the agonist of HO) was intrathecally injected to the normal rats. The weighted pain scores were used to evaluate the degree of pain response. Thermal withdrawal latency and mechanical withdrawal threshold were observed to assess the degree of thermal hyperalgesia and mechanical allodynia...
January 2013: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/21334511/acupuncture-as-adjuvant-therapy-in-thalamic-syndrome-case-report
#5
Alysson Bruno Oliveira Santos, Judymara Lauzi Gozzani
BACKGROUND AND OBJECTIVES: Cerebrovascular diseases are responsible for a large proportion of deaths in the world. Among survivors, the majority of limiting sequelae observed is motor in origin; but when sensorial pathways or centers are affected patients can evolve with sensorial changes in the body region represented by the area of the brain affected. When the affected area is related to the thalamus the patient might develop thalamic syndrome. The objective of this report was to demonstrate the use of electroacupuncture as adjuvant in the treatment of central pain, diagnosed as thalamic syndrome difficult to control with pharmacologic therapy...
January 2011: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/21189552/-activation-of-periphery-group-iii-metabotropic-glutamate-receptors-inhibits-formalin-induced-activation-of-spinal-p38-mapk-in-rats
#6
Xiao-chun Yan, Zhi-feng Peng, Xiao-rong Yang, Xin Zhao, Nai-hong Liu, Xing Jin, Qiao Cheng, Ce Zhang
AIM: To explore the effects of periphery injection of L-SOP on the activation of p38MAPK in spinal cord in formalin pain model in rats. METHODS: Fourty-eight male Wistar rats were divided randomly into four groups (n=12): NS group and three different dose of L-SOP groups. For each group, 6 rats used to observe flinching and licking time every as nociception behavior 3 minutes in 1 hour after formalin injected and the other 6 rats used to observe the activation of p38(P-p38) by Western blotting...
May 2009: Chinese Journal of Applied Physiology
https://www.readbyqxmd.com/read/19749220/balloon-related-complications-and-technical-failures-in-kyphoplasty-for-vertebral-fractures
#7
G Saliou, D R Rutgers, E M Kocheida, G Langman, A Meurin, H Deramond, P Lehmann
BACKGROUND AND PURPOSE: Our aim was to describe the immediate or early complications and technical failures occurring during balloon kyphoplasty (BKP) procedures and attributable to balloon inflation. MATERIALS AND METHODS: We performed a retrospective review of all consecutive kyphoplasty procedures performed in our institution from May 2005 to October 2006. Fifty-one patients were treated by BKP at 75 spinal levels, and 137 vertebroplasties were performed as well...
January 2010: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/19224057/-changes-in-voltage-gated-potassium-currents-in-the-trigeminal-neurons-after-a-chronic-constriction-of-infraorbital-nerve
#8
Na Li, Chao Li, Juan Fan, Xiao-Zhong Jiang, Jin-Bao Li, Xiao-Ming Deng, Bei Ma
The purpose of this study was to establish a model of trigeminal neuralgia (TN) through an approach from lower edge of cheekbone and to observe the functional changes in the voltage-gated potassium currents in the cultured trigeminal ganglion (TG) neurons. Thirty Sprague-Dawley male rats were divided into two groups, the sham-operated (sham) group and the operated group. The TN model was carried out by using a chronic constriction injury of the infraorbital nerve (ION-CCI) from lower edge of cheekbone. Peripheral pain threshold test and whole-cell patch clamp recording were used to determine the difference between sham and ION-CCI rats...
February 25, 2009: Sheng Li Xue Bao: [Acta Physiologica Sinica]
https://www.readbyqxmd.com/read/18930216/smooth-muscle-metaplasia-and-innervation-in-interstitium-of-endometriotic-lesions-related-to-pain
#9
Kohei Odagiri, Ryo Konno, Hiroyuki Fujiwara, Sachiho Netsu, Chenghui Yang, Mitsuaki Suzuki
OBJECTIVE: To investigate the pathogenesis of endometriotic pain. DESIGN: Retrospective nonrandomized immunohistochemical study. SETTING: A university hospital, Department of Gynecology. PATIENT(S): Twenty human endometriotic specimens were selected from different lesions including ovarian endometrioma, peritoneal lesion, and deep infiltrating lesion. Premenopausal women with histologically diagnosed endometriosis were selected (mean age 39 years; range, 25-53 years)...
November 2009: Fertility and Sterility
https://www.readbyqxmd.com/read/18038807/-clinical-observation-on-25-cases-of-severe-angiostrongyliasis-cantonensis
#10
Jing Wang, Xiao-yan Zheng, Cheng-hong Yin, Hai-yu Qi, Xiao-li Li, Zong-li Diao, Fei Wang, Ai-ping Ji, Man-ling Feng, Zeng-zhu Guo
OBJECTIVE: To summarize the clinical features of severe angiostrongyliasis cantonensis (AC) patients. METHODS: Clinical data on symptoms, physical signs, auxiliary examination and prognosis of 25 severe AC patients hospitalized in June-Sept 2006 were analyzed. RESULTS: Epidemiologically, all cases had eaten uncooked fresh water snails. One of the early symptoms was fever (16 cases, 64.0%), including 8 cases with low-grade fever, 7 cases with mid-range fever, and 1 case high fever...
August 2007: chinese Journal of Parasitology & Parasitic Diseases
https://www.readbyqxmd.com/read/17393754/discography-over-50-years-of-controversy
#11
REVIEW
Heather J Wichman
Low back pain is estimated to affect 80% of the general population at least once in their lifetime. It is the fifth leading cause of medical clinic visits and the leading work-related disability. Lumbar discography has been used to diagnose the source of low back pain when non-invasive imaging, such as magnetic resonance (MR), does not reveal morphologic abnormality consistent with symptoms. Controversy regarding the usefulness of discography has been ongoing for over 50 years. Modern advancements with imaging and technique still have not been sufficient to justify the practicality of this procedure for standard use...
February 2007: WMJ: Official Publication of the State Medical Society of Wisconsin
https://www.readbyqxmd.com/read/16927963/neurochemistry-of-trigeminal-activation-in-an-animal-model-of-migraine
#12
Michael L Oshinsky, Jia Luo
Research techniques such as electrophysiology, cFos protein expression, and other measurements of neuronal activation provide insights into the pathophysiology of pain processing in migraine, but they do not indicate the specific neurotransmitter systems involved. This paper summarizes data from microdialysis experiments in which changes in the neurochemistry of the trigeminal nucleus caudalis (TNC) were monitored during dural stimulation. Microdialysis allows the measurement of extracellular concentrations of neurotransmitters in a small area of the brain, in vivo, by means of a probe equipped with a semipermeable membrane...
June 2006: Headache
https://www.readbyqxmd.com/read/16298070/assessment-of-nociception-in-acrylamide-induced-neuropathy-in-rats
#13
Bing Ling, Nicolas Authier, David Balayssac, Alain Eschalier, François Coudore
Acrylamide was intraperitoneally administered to male Sprague-Dawley rats at four different doses (5, 10, 20 and 30 mg/kg) three times a week for 5 consecutive weeks. Because of motor dysfunction, the 30 mg/kg dose was not used for behavioral pain tests. Clinical status remained good throughout the experiment and no motor deficit was observed at the other doses. We showed that acrylamide administration at low doses and cumulative dose (CD) range of 35-140 mg/kg produced mechanical allodynia and rapid, marked heat (42 degrees C) and cold (10 degrees C) allodynia after tail immersion test...
December 15, 2005: Pain
https://www.readbyqxmd.com/read/15247865/-thoughts-on-the-definition-of-postherpetic-pain-the-time-criterion-adds-nothing
#14
REVIEW
(no author information available yet)
In postherpetic neuralgia, as in all types of neuropathic pain, it is generally accepted that outcome can be affected early management with specific analgesics. However, when one looks at the diagnostic criteria appearing in the literature, there is no consensus. Authors use the notion of latency to situate the onset of postherpetic neuralgia within the continuum of herpetic pain. Depending on the Author, this latency period ranges from one to six Months after the skin eruption. This latency is poorly compatible with early intervention and not well-adapted to everyday practice...
July 2004: Revue Neurologique
https://www.readbyqxmd.com/read/15071926/-effect-of-clonidine-on-rat-s-behavior-response-and-spinal-nitric-oxide-in-formalin-test
#15
Xue-mei Lin, Hong-wei Xu, Quan-yun Wang, Wei Huang, Bang-xiang Yang, Lin Zhu
OBJECTIVE: To assess the effect of Clonidine on SD rat's behavior response and spinal nitric oxide in the formalin test. METHODS: The effects of Clonidine (Clo), L-arginine(L-Arg), and NG-nitro-L-arginine (L-NAME) on the flinching and licking time of rats in the formalin test were assessed using the model of formalin-induced hyperalgia. RESULTS: The flinching and licking time of group Clo was shorter (38.60 +/- 17.34) s/5 min than that of group Formalin(155...
March 2004: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/14383139/-genesis-of-labor-hyperalgia-limitations-for-psychoprophylactic-pain-relief
#16
H J PRILL
No abstract text is available yet for this article.
March 31, 1955: Medizinische Klinik
https://www.readbyqxmd.com/read/14164562/-treatment-of-rheumatic-hyperalgias-with-hydroxocobalamine-vit-b-12-b-5000-micrograms
#17
H MONGES, A HANCY, P OHRESSER
No abstract text is available yet for this article.
1964: Marseille Médical
https://www.readbyqxmd.com/read/14136909/-hydroxocobalamin-in-large-doses-in-rheumatic-hyperalgia
#18
L ISEMEIN, D UNAL, ACQUAVIVA
No abstract text is available yet for this article.
1964: Marseille Médical
https://www.readbyqxmd.com/read/12799805/-alpha-2-adrenergic-agonists-use-in-chronic-pain-a-meta-analysis
#19
J Motsch, M Kamler
alpha(2)-adrenergic agonists, mimicking the action of the inhibitory transmitter norepinephrine, cause antinociception due to postsynaptic inhibition of spinothalamic projection neurons, presynaptic inhibition at the central nervous system termination of primary sensory nerves, presynaptic inhibition of brainstem noradrenergic neurons and a generalized decrease in central nervous system sympathetic efferent activity. There is a mutual potentiation of antinociceptive effects of clonidine and morphine. Clonidine is used in chronic pain states for treatment of neuropathic, neuralgic and deafferentiating pain...
October 24, 1997: Der Schmerz
https://www.readbyqxmd.com/read/12113904/absence-of-painful-neuropathy-after-chronic-oral-fluoride-intake-in-sprague-dawley-and-lou-c-rats
#20
David Balayssac, Damien Richard, Nicolas Authier, Alain Nicolay, Didier Jourdan, Alain Eschalier, François Coudoré
The possibility that chronicle oral ingestion of fluoride-rich water could modify peripheral pain sensitivity was studied in two strains of adult rats, Sprague-Dawley and Lou/C rats. Sodium fluoride was given orally in water to male Sprague-Dawley (75 and 150 ppm) and Lou rats (150 ppm) for 15 and 27 weeks, respectively. Using classical behavioural evaluation methods of pain symptoms, only slight tendencies to a thermal hyperalgia and a mechanical allodynia were observed in Sprague-Dawley rats.
July 26, 2002: Neuroscience Letters
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