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Emmanuel Kiyana Muyumba, Dophra Ngoy Nkulu, Clarence Kaut Mukeng, Jacques Mbaz Musung, Placide Kambola Kakoma, Christian Ngama Kakisingi, Oscar Numbi Luboya, Françoise Kaj Malonga, Justin Kalungwe Kizonde, Olivier Mukuku, Weili Yan
BACKGROUND: The diagnosis of hypertension in children is complex because based on normative values by sex, age and height, and these values vary depending on the environment. Available BP references used, because of the absence of local data, do not correspond to our pediatric population. Accordingly, our study aimed to provide the BP threshold for children and adolescents in Lubumbashi (DRC) and to compare them with German (KIGGS study), Polish (OLAF study) and Chinese (CHNS study) references...
January 19, 2018: BMC Cardiovascular Disorders
Veronica Goian, Florian O Schumann, Wolf Widdra
We report on the surface phonons of long-range ordered BaO thin films grown on Pt(001). In the thickness range between 4 and 28 ML, we find unstrained BaO(001)-(1x1) bulk-like terminated films which coincide with a Pt(001)-c(2x2) lattice periodicity. The dipole-active lattice vibrations were determined using high-resolution electron energy loss spectroscopy. For all BaO film thicknesses, a single Fuchs-Kliewer (FK) phonon-polariton is observed. Its intensity increases and its frequency softens with increasing film thickness...
January 19, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Kathryn Glaser, Peter Dickie, Derek Neilson, Alexander Osborn, Belinda Hsi Dickie
BACKGROUND: Lymphatic endothelial cells (LECs) derived from lymphatic malformations (LMs) bear activated PIK3CA alleles yet display an inflammatory gene expression profile. A basis for the inflammatory phenotype was sought by screening for coexisting somatic mutations. METHODS AND RESULTS: Fourteen independent LEC populations bearing activated PIK3CA alleles were isolated from LM. These were characterized by the expression of growth and inflammatory genes (VEGFC, IL-6, COX-2, IL-8, HO-1, E-SEL) by qRT-PCR...
January 18, 2018: Lymphatic Research and Biology
Juliette Piard, James Lespinasse, Marketa Vlckova, Martin A Mensah, Sorin Iurian, Martina Simandlova, Marcela Malikova, Oliver Bartsch, Massimiliano Rossi, Marion Lenoir, Frédérique Nugues, Stefan Mundlos, Uwe Kornak, Philip Stanier, Sérgio B Sousa, Lionel Van Maldergem
The cutis laxa syndromes are multisystem disorders that share loose redundant inelastic and wrinkled skin as a common hallmark clinical feature. The underlying molecular defects are heterogeneous and 13 different genes have been involved until now, all of them being implicated in elastic fiber assembly. We provide here molecular and clinical characterization of three unrelated patients with a very rare phenotype associating cutis laxa, facial dysmorphism, severe growth retardation, hyperostotic skeletal dysplasia, and intellectual disability...
January 17, 2018: American Journal of Medical Genetics. Part A
B Díaz-Garduño, J A Perales, C Garrido-Pérez, M L Martín-Díaz
A mobile pilot plant was set up in a wastewater treatment plant (WWTP) in southwest Spain to address potential adverse effects of effluents as a whole contaminant, which are discharging into marine environments. Ruditapes philippinarum specimens were exposed to different effluent concentrations (50%, 25%, 12.5%, 6.25%, and 3.15%) during seven days. After effluent exposure, lysosomal membrane stability alterations (LMS), changes in the energy status storage (total lipids content (TLP) and in the mitochondrial electron transport (MET), inhibition of inflammatory mechanisms (cyclooxygenase activity (COX)), and neurotoxic effects (acetylcholinesterase (AChE) were determined in exposed organisms...
January 12, 2018: Environmental Pollution
Kana Ishii, Hidetoshi Sakurai, Nobuharu Suzuki, Yo Mabuchi, Ichiro Sekiya, Kiyotoshi Sekiguchi, Chihiro Akazawa
Satellite cells function as precursor cells in mature skeletal muscle homeostasis and regeneration. In healthy tissue, these cells are maintained in a state of quiescence by a microenvironment formed by myofibers and basement membrane in which LAMININs (LMs) form a major component. In the present study, we evaluated the satellite cell microenvironment in vivo and found that these cells are encapsulated by LMα2-5. We sought to recapitulate this satellite cell niche in vitro by culturing satellite cells in the presence of recombinant LM-E8 fragments...
January 10, 2018: Stem Cell Reports
Ranjan Agrawal, Miti Gupta, Nitesh Mohan, Jagdamba Sharan, Parbodh Kumar
Soft tissue sarcomas of the genitourinary tract are rare. Paratesticular sarcomas are extremely rare with majority of scrotal masses localizing to the testis and being neoplastic in nature. Paratesticular leiomyosarcomas (LMSs) are located in the spermatic cord, epididymis, or scrotum. However, their location in the scrotal skin or subcutaneous tissue is extremely rare. Only 10 cases have been reported from India previously. Ours is the 11th case. A 50-year-old male presented with a recurrent scrotal mass which was painless and gradually increasing in size...
October 2017: Indian Journal of Pathology & Microbiology
Priya Chudasama, Sadaf S Mughal, Mathijs A Sanders, Daniel Hübschmann, Inn Chung, Katharina I Deeg, Siao-Han Wong, Sophie Rabe, Mario Hlevnjak, Marc Zapatka, Aurélie Ernst, Kortine Kleinheinz, Matthias Schlesner, Lina Sieverling, Barbara Klink, Evelin Schröck, Remco M Hoogenboezem, Bernd Kasper, Christoph E Heilig, Gerlinde Egerer, Stephan Wolf, Christof von Kalle, Roland Eils, Albrecht Stenzinger, Wilko Weichert, Hanno Glimm, Stefan Gröschel, Hans-Georg Kopp, Georg Omlor, Burkhard Lehner, Sebastian Bauer, Simon Schimmack, Alexis Ulrich, Gunhild Mechtersheimer, Karsten Rippe, Benedikt Brors, Barbara Hutter, Marcus Renner, Peter Hohenberger, Claudia Scholl, Stefan Fröhling
Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically actionable genetic vulnerabilities, are largely unknown. Here we show, using whole-exome and transcriptome sequencing, that LMS tumors are characterized by substantial mutational heterogeneity, near-universal inactivation of TP53 and RB1, widespread DNA copy number alterations including chromothripsis, and frequent whole-genome duplication. Furthermore, we detect alternative telomere lengthening in 78% of cases and identify recurrent alterations in telomere maintenance genes such as ATRX, RBL2, and SP100, providing insight into the genetic basis of this mechanism...
January 10, 2018: Nature Communications
Tomohiro Ando, Hiroki Kato, Tatsuro Furui, Ken-Ichirou Morishige, Satoshi Goshima, Masayuki Matsuo
OBJECTIVE: Hyperintense area on T1-weighted images (T1 HIA) have been reported as suggestive features of uterine leiomyosarcoma (LMS), but differentiating LMS from leiomyoma (LM) is often difficult. This study aimed to evaluate the differences between uterine LMS and LM demonstrating intratumoral T1 HIA. METHODS: MR imaging was performed in 509 patients with 1,137 uterine smooth muscle tumors [14 LMSs, five smooth muscle tumors of uncertain malignant potential (STUMPs), and 1,118 LMs] which exceeded 3 cm in diameter...
January 8, 2018: British Journal of Radiology
Marie Kostine, Inge H Briaire-de Bruijn, Arjen H G Cleven, Carly Vervat, Willem E Corver, Marco W Schilham, Els Van Beelen, Hester van Boven, Rick L Haas, Antoine Italiano, Anne-Marie Cleton-Jansen, Judith V M G Bovée
Background: Immunotherapy may be a rational strategy in leiomyosarcoma (LMS), a tumor known for its genomic complexity. As a prerequisite for therapeutic applications, we characterized the immune microenvironment in LMS, as well as its prognostic value. Methods: CD163+ macrophages, CD3+ T-cells, PD-L1/PD-L2 and HLA class I expression (HCA2, HC10 and β2m) were evaluated using immunohistochemistry in primary tumors (n = 75), local relapses (n = 6) and metastases (n = 19) of 87 LMS patients, as well as in benign leiomyomas (n = 7)...
2018: Oncoimmunology
Nicholas J Lintel, Stephen A Luebker, Subodh M Lele, Scott A Koepsell
Morphologically, distinguishing between leiomyoma (LM) and leiomyosarcoma (LMS) is not always straightforward, especially with benign variants such as bizarre leiomyoma (BLM). To identify potential markers of malignancy in uterine smooth muscle tumors, proteomic studies were performed followed by assessment of protein expression by immunohistochemistry. Archival formalin-fixed paraffin-embedded (FFPE) tissues from tumors (n=23) diagnosed as LM, BLM and LMS (using published criteria) were selected for the study...
January 4, 2018: Human Pathology
Vaman Khadilkar, Shashi Chiplonkar, Veena Ekbote, Neha Kajale, Rubina Mandlik, Anuradha Khadilkar
BACKGROUND: Childhood obesity and its consequences have reached alarming proportions worldwide and in India. Wrist circumference is emerging as an easily measurable reproducible parameter for screening children at risk of obesity-related morbidities such as hypertension and insulin resistance. The objectives of this study were: (1) to compute age and gender-specific wrist circumference percentiles for 3-18-year-old apparently healthy Indian children and adolescents; (2) to assess the relationship of wrist circumference with measures of obesity and adiposity such as body mass index (BMI), fat percentage and blood pressure (BP) and (3) to suggest age and gender-specific cut-offs for wrist circumference percentile for the risk of hypertension in Indian children and adolescents...
January 8, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
Susanna Sforzini, Michael N Moore, Caterina Oliveri, Anna Volta, Awadhesh Jha, Mohamed Banni, Aldo Viarengo
Lysosomal membrane stability (LMS) has been used in various organisms as a very sensitive biomarker of stress. However, despite the abundance of data about regulation of the autophagic process in mammals, in the invertebrates there is only limited mechanistic understanding. Marine mussels (Mytilus galloprovincialis Lam.) are bivalve molluscs, widely used as models in ecotoxicology and as environmental bioindicators of sea water quality. In order to elucidate this fundamental process, in the present study, mussels were exposed for 3 days to a "priority", ubiquitous environmental contaminant, benzo[a]pyrene (B[a]P) at different concentrations (i...
December 28, 2017: Aquatic Toxicology
Derman Basaran, Alp Usubutun, Mehmet Coskun Salman, Mehmet Ali Narin, Gokhan Boyraz, Osman Turkmen, Gunsu Comert Kimyon, Alper Karalok, Dilek Bulbul, Taner Turan, Nejat Ozgul, Kunter Yuce
OBJECTIVE: The objective of this study was to investigate the clinicopathological features and factors associated with recurrence in patients with uterine smooth muscle tumor of uncertain malignant potential (STUMP). METHODS: Forty-six cases diagnosed between 2000 and 2014 from 2 tertiary centers underwent blind slide review. Initial diagnosis included smooth muscle tumors with equivocal diagnosis, STUMPs, and cases that were named as leiomyosarcomas (LMS) or low-grade LMS despite not fulfilling the Stanford criteria...
January 4, 2018: International Journal of Gynecological Cancer
Sachidanand Gautam, Rajesh K Meena
Background: Primary intracranial leiomyosarcomas (LMSs) are unusual tumors of the central nervous system (CNS) affecting all age groups, and are recently, becoming more prevalent in immunosuppressive conditions such as in patients with human immunodeficiency virus (HIV) infection. However, only a few CNS LMS case reports exist in the English literature, on the occurrence of this rare entity in immunocompetent adults. Even, rarer is a purely intraparenchymal occurrence without any dural attachment in afflicted individuals...
2017: Surgical Neurology International
Melchor Alpizar, Vanessa-Giselle Peschard, Fabiola Escalante-Araiza, Nelly F Altamirano-Bustamante, Chiharu Murata, Ramón Arenas-Pérez, Ernesto Rodriguez-Ayala
Overweight children and childhood obesity are a public health problem in Mexico. Obesity is traditionally assessed using body mass index (BMI), but an excess of adiposity does not necessarily reflect a high BMI. Thus, body composition indexes are a better alternative. Our objective was to generate body composition percentile curves in children from Mexico City. A total of 2026 boys and 1488 girls aged 6 to 12 years old were studied in Mexico City. Body weight, height, and BMI calculation were measured. Total body fat percentage (TBFP) was derived from the skinfold thicknesses, and fat mass (FMI) and free fat mass indexes (FFMI) were calculated...
December 20, 2017: Children
Qing Zhang, Margaux Jenna Kanis, Julianne Ubago, Dachao Liu, Denise M Scholtens, Anna E Strohl, John R Lurain, Shohreh Shahabi, Beihua Kong, Jian-Jun Wei
Uterine smooth muscle tumors (USMT) consist of a group of histologically heterogeneous and clinically diverse diseases ranging from malignant leiomyosarcoma (LMS) to benign leiomyoma (ULM). The genetic alterations in LMS are complex with some genetic alterations present in both LMS and other atypical histologic variants of USMT. In this study we reviewed 119 USMT with a diagnosis of LMS, STUMP (smooth muscle tumor of uncertain malignant potential), ALM/LM-BN (atypical leiomyomas/leiomyoma with bizarre nuclei) and CLM (cellular leiomyoma) as well as 46 ULM and 60 myometrial controls...
December 16, 2017: Human Pathology
William H Parker
PURPOSE OF REVIEW: Minimally invasive gynecologic procedures, in particular laparoscopic hysterectomy and myomectomy, often require tissue morcellation. RECENT FINDINGS: Whether morcellated or not, myometrial cells can be found in the abdomen and pelvis after either laparoscopic or open myomectomy. Following morcellation, careful inspection for and removal of tissue fragments and copious irrigation and suctioning of fluid can remove residual tissue and cells without the use of containment bags...
February 2018: Current Opinion in Obstetrics & Gynecology
Elizabeth A Pritts
PURPOSE OF REVIEW: To review the data-derived prevalence rates for occult leiomyosarcoma (LMS), and outcomes for women who have these tumors inadvertently morcellated. RECENT FINDINGS: In 2014, the Food and Drug Administration presented data showing the prevalence rates of occult LMS at 2.02/1000 surgeries for presumed benign fibroids. They also attributed poorer outcomes for women undergoing power morcellation of these tumors. Two more recent meta-analyses have shown much lower rates, as low as one in 8300 surgeries when including only prospective studies, and one in 1428 surgeries when including both prospective and retrospective studies...
February 2018: Current Opinion in Obstetrics & Gynecology
Vasilios Tanos, Hans Brölmann, Rudi Leon DeWilde, Peter O'Donovan, Elina Symeonidou, Rudi Campo
Background: Increased awareness of leiomyosarcoma (LMS) risk during myomectomy or hysterectomy is essential. Objective and correct reasoning should prevail on any decision regarding the extent and type of surgery to employ. The anticipated risk of a sarcoma after myoma or uterus morcellation is low, and the frequency of leiomyosarcoma especially in women below the age of 40 is very rare. The prevalence data has a wide range and is therefore not reliable. The European Society of Gynaecological Endoscopy (ESGE) initiated a survey among its members looking into the frequency of morcellated leiomyosarcoma after endoscopic surgery...
2017: Gynecological Surgery
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