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https://www.readbyqxmd.com/read/27911244/neurosurgical-management-in-lateral-meningocele-syndrome-case-report
#1
Erik C Brown, Kunal Gupta, Christina Sayama
Lateral meningocele syndrome (LMS) is a rare genetic connective tissue disorder. It is associated with morphological changes similar to those of other connective tissue disorders, with the unique distinction of multiple, often bilateral and large, lateral meningoceles herniating through the spinal foramina. In some cases, these lateral meningoceles can cause pain and discomfort due to their presence within retroperitoneal tissues or cause direct compression of the spinal nerve root exiting the foramen; in some cases compression may also involve motor weakness...
December 2, 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27900663/mir-152-down-regulation-is-associated-with-met-up-regulation-in-leiomyosarcoma-and-undifferentiated-pleomorphic-sarcoma
#2
Laura Pazzaglia, Chiara Novello, Amalia Conti, Serena Pollino, Piero Picci, Maria Serena Benassi
PURPOSE: Highly aggressive adult soft tissue sarcomas (STS), i.e., leiomyosarcomas (LMS) and undifferentiated pleomorphic sarcomas (UPS), present complex genomic anomalies and overall 5-year survival rates of 20 to 40%. Here, we aimed to identify new biomarkers that may be employed to improve the treatment of non-translocation STS patients. We validated 12 miRNAs implicated in tumor development using primary STS samples and selected miR-152 for further analysis in STS-derived cell lines...
November 29, 2016: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/27891824/lipidomic-profiling-of-high-fat-diet-induced-obesity-in-mice-importance-of-cytochrome-p450-derived-fatty-acid-epoxides
#3
Weicang Wang, Jun Yang, Weipeng Qi, Haixia Yang, Chang Wang, Bowen Tan, Bruce D Hammock, Yeonhwa Park, Daeyoung Kim, Guodong Zhang
OBJECTIVE: Enzymatic metabolism of polyunsaturated fatty acids leads to formation of bioactive lipid metabolites (LMs). Previous studies have shown that obesity leads to deregulation of LMs in adipose tissues. However, most previous studies have focused on a single or limited number of LMs, and few systematical analyses have been carried out. METHODS: A LC-MS/MS-based lipidomics approach was used, which can analyze >100 LMs produced by cyclooxygenase, lipoxygenase, and cytochrome P450 (CYP) enzymes, to analyze the profile of LMs in high-fat diet-induced obesity in mice...
November 28, 2016: Obesity
https://www.readbyqxmd.com/read/27882721/survival-of-patients-with-metastatic-leiomyosarcoma-the-md-anderson-clinical-center-for-targeted-therapy-experience
#4
Zhijie Wang, Naiyi Shi, Aung Naing, Filip Janku, Vivek Subbiah, Dejka M Araujo, Shreyaskumar R Patel, Joseph A Ludwig, Lois M Ramondetta, Charles F Levenback, Pedro T Ramirez, Sarina A Piha-Paul, David Hong, Daniel D Karp, Apostolia M Tsimberidou, Funda Meric-Bernstam, Siqing Fu
Advanced stage leiomyosarcoma (LMS) is incurable with current systemic antitumor therapies. Therefore, there is clinical interest in exploring novel therapeutic regimens to treat LMS. We reviewed the medical records of 75 consecutive patients with histologically confirmed metastatic LMS, who had been referred to the Clinical Center for Targeted Therapy at MD Anderson Cancer Center. To lay the foundation for potential phase I trials for the treatment of advanced LMS, we analyzed tumor response and survival outcome data...
November 23, 2016: Cancer Medicine
https://www.readbyqxmd.com/read/27879507/pedicle-screw-combined-with-lateral-mass-screw-fixation-in-the-treatment-of-basilar-invagination-and-congenital-c2-c3-fusion
#5
Shenglin Wang, Chao Wang, Huijie Leng, Weidong Zhao, Ming Yan, Haitao Zhou
STUDY DESIGN: Clinical evaluation of a surgical fixation technique featuring combined use of pedicle screw and lateral mass screw (LMS). OBJECTIVE: Introduction of a novel technique for the treatment of congenital C2-C3 fusion and basilar invagination (BI). SUMMARY OF BACKGROUND: Posterior occipitocervical fixation using C2 pedicle screw was widely used for BI. However, in cases where BI is concurrent with congenital C2-C3 fusion, the C2 pedicles tend to be thinner than that in normal population and hence more likely to fail...
December 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27864989/the-mitosis-specific-marker-phosphohistone-h3-phh3-is-an-independent-prognosticator-in-uterine-smooth-muscle-tumors-an-outcome-based-study
#6
Kin-Long Chow, Ka-Yu Tse, Ching-Lung Cheung, Ka-Wing Wong, Annie N Y Cheung, Richard W C Wong, Alice N H Chan, Nancy W F Yuen, Hextan Y S Ngan, Philip P C Ip
: Accurate mitosis-counting, which is important in the diagnosis of uterine smooth muscle tumors (USMT), is often difficult and subjective. The mitosis-specific immunohistochemical marker phosphohistone H3 (PHH3) has been shown to be diagnostically useful but its expression, in relation to outcome, has not been thoroughly investigated. AIMS AND METHODS: PHH3 expression was evaluated on 55 leiomyosarcomas (LMSs), 26 smooth muscle tumors of uncertain malignant potential (STUMPs), 18 leiomyomas with bizarre nuclei (LBNs) and 12 leiomyomas (LMs)...
November 16, 2016: Histopathology
https://www.readbyqxmd.com/read/27856693/construction-of-lambda-mu-sigma-values-for-determining-mid-upper-arm-circumference-z-scores-in-u-s-children-aged-2-months-through-18-years
#7
Susan M Abdel-Rahman, Charlie Bi, Kristi Thaete
BACKGROUND: Mid-upper arm circumference (MUAC) has proven highly predictive of morbidity and mortality associated with malnutrition better, in some cases, than other growth indicators, including body mass index (BMI) z scores and weight-for-height z scores. A recent consensus statement recommended the inclusion of MUAC and MUAC z scores in the nutrition assessment of children in the United States; however, the requisite data to permit z score calculations for children aged >5 years have not been published...
November 17, 2016: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/27849343/recurrent-uterine-leiomyosarcoma-an-atypical-location
#8
Mesut Köse, Fatih Çelik, Seda Kayman Köse, Dağıstan Tolga Arıöz, Mehmet Yılmazer, Çiğdem Tokyol
Leiomyosarcoma (LMS) is a malignant tumor of smooth muscle cells and comprises 5-24% of all soft tissue sarcomas. Although the most frequent symptoms are vaginal bleeding and abdominal pain, the symptoms are generally associated with dimensions and localization of the tumor. The current study presents a case of uterine leiomyosarcoma that metastasized to the rectus abdominis muscle, which has only been previously reported in two cases in the literature. A 57-year-old multigravid patient presented with a palpable mass in her abdomen...
November 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/27836363/prenatal-growth-characteristics-of-lymphatic-malformations
#9
William H Peranteau, Suzanne D Iyoob, Matthew M Boelig, Nahla Khalek, Julie S Moldenhauer, Mark P Johnson, Holly L Hedrick, Alan W Flake, Beverly G Coleman, N Scott Adzick
PURPOSE: The natural history of prenatally diagnosed lymphatic malformations (LM) remains unknown. The ability to predict growth of a lesion is important to prenatal counseling and any future prenatal intervention. We describe the prenatal growth patterns of LMs as they relate to gestational age, anatomical location, and postnatal management. METHODS: A retrospective review of fetuses prenatally diagnosed with an LM who were followed with serial ultrasounds from 2003 to 2014 was performed with attention to the growth of the lesion as indicated by the lesion volume ratio (LVR)...
October 27, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27834491/full-information-maximum-likelihood-estimation-for-latent-variable-interactions-with-incomplete-indicators
#10
Heining Cham, Evgeniya Reshetnyak, Barry Rosenfeld, William Breitbart
Researchers have developed missing data handling techniques for estimating interaction effects in multiple regression. Extending to latent variable interactions, we investigated full information maximum likelihood (FIML) estimation to handle incompletely observed indicators for product indicator (PI) and latent moderated structural equations (LMS) methods. Drawing on the analytic work on missing data handling techniques in multiple regression with interaction effects, we compared the performance of FIML for PI and LMS analytically...
November 11, 2016: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/27828445/experimental-demonstration-of-608gbit-s-short-reach-transmission-employing-half-cycle-16qam-nyquist-scm-signal-and-direct-detection-with-25gbps-eml
#11
Kangping Zhong, Xian Zhou, Yiguang Wang, Liang Wang, Jinhui Yuan, Changyuan Yu, Alan Pak Tao Lau, Chao Lu
In this paper, we experimentally demonstrated an IM/DD short reach transmission system with a total capacity of 608Gbit/s (net capacity of 565.4Gbit/s exclude 7% FEC overhead) employing half-cycle 16QAM Nyquist-SCM signal and 25Gbps EML at O band. Direct detection-faster than Nyquist (DD-FTN) technique was employed to compensate channel impairments. Number of taps of DD-LMS and tap coefficient of post filter in DD-FTN were experimentally studied for different baud rates. Single-lane 152Gbit/s transmission over 10km of SSMF was experimentally demonstrated...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27825029/the-role-of-fibroblast-growth-factor-2-in-patients-with-uterine-smooth-muscle-tumors-an-immunohistochemical-study
#12
Barbara Bodner-Adler, Klaus Mayerhofer, Klaus Czerwenka, Oliver Kimberger, Heinz Koelbl, Klaus Bodner
OBJECTIVE: Fibroblast growth factor 2 (FGF-2) is considered to be a potent stimulator of angiogenesis and seems therefore to play an important role in the growth of tumors. We compared the immunohistochemical profile of FGF-2 in patients with uterine leiomyomas, smooth muscle tumors of uncertain malignant potential (STUMP) and leiomyosarcoma (LMS). Furthermore, we tried to clarify the prognostic role of FGF-2 in uterine leiomyosarcoma. STUDY DESIGN: FGF-2 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 cases with STUMP and in 21 patients with LMS...
October 29, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27820732/a-rare-intramedullary-spinal-cord-metastasis-from-a-retroperitoneal-leiomyosarcoma-presenting-as-a-non-traumatic-spinal-cord-injury
#13
Andrew Lamberth Parker, Terrence Pugh, Mark A Hirsch
Leiomyosarcoma (LMS) is a rare but well-recognized malignant soft tissue sarcoma of smooth muscle origin. Metastases commonly occur in the lungs, liver, kidney, brain, and bone. Cases of metastatic osseous lesions or other extradural space-occupying masses secondary to LMS leading to neurologic compromise are relatively commonplace in the literature. Conversely, cases of intramedullary spinal cord metastasis (ISCM), an unusual entity as a sequela of any cancer, are exceedingly rare as a consequence of LMS. Only 2 cases of an ISCM from LMS are currently documented in the literature, and to the best of our knowledge, no case is described in the rehabilitation literature...
November 4, 2016: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/27817933/morcellation-worsens-survival-outcomes-in-patients-with-undiagnosed-uterine-leiomyosarcomas-a-retrospective-mito-group-study
#14
Francesco Raspagliesi, Giuseppa Maltese, Giorgio Bogani, Giovanni Fucà, Stefano Lepori, Pierandrea De Iaco, Myriam Perrone, Giovanni Scambia, Gennaro Cormio, Stefano Bogliolo, Alice Bergamini, Giuseppe Bifulco, Paolo Giovanni Casali, Domenica Lorusso
OBJECTIVE: To investigate the impact of morcellation on survival outcomes of patients affected by undiagnosed uterine sarcoma. METHODS: This is a retrospective study performed in 8 referral centers of MITO group. Data of women undergoing morcellation for apparent benign uterine myomas who were ultimately diagnosed with stage I uterine sarcoma on final pathology were compared with data of women who did not undergo morcellation. Uterine sarcoma included: leiomyosarcomas (LMS), smooth muscle tumors of uncertain malignant potential (STUMP), low-grade endometrial stromal sarcomas (LG-ESS) and undifferentiated uterine sarcomas (UUS)...
November 4, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27816171/reliable-exclusion-of-prognostically-significant-coronary-disease-in-left-ventricular-dysfunction-by-cardiac-mri
#15
A C M Thompson, J G Crilley, D W Wilson, A P S Hungin, A Fuat, J J M Murphy
AIM: To assess the ability of cardiac magnetic resonance (CMR) to exclude prognostically significant coronary artery disease (CAD) in patients with left ventricular systolic dysfunction (LVSD). MATERIALS AND METHODS: A cohort of patients who underwent both X-ray angiography and CMR since 2006 was reviewed retrospectively. Records of those with European criteria for LVSD (left ventricular ejection fraction [LVEF] <50% or LV end-diastolic volume index [LVEDVI] ≥97 ml/m(2)) on CMR or transthoracic echo were analysed...
November 2, 2016: Clinical Radiology
https://www.readbyqxmd.com/read/27805802/tailored-fabrication-of-transferable-and-hollow-weblike-titanium-dioxide-structures
#16
Arto Hiltunen, Kimmo Lahtonen, Jesse Saari, Anniina Ojanperä, Essi Sarlin, Holger Wondraczek, Alexander Efimov, Kimmo Kaunisto, Paola Vivo, Chiara Maccato, Davide Barreca, Pedro Fardim, Nikolai Tkachenko, Mika Valden, Helge Lemmetyinen
The preparation of weblike titanium dioxide thin films by atomic layer deposition on cellulose biotemplates is reported. The method produces a TiO2 web, which is flexible and transferable from the deposition substrate to that of the end application. Removal of the cellulose template by calcination converts the amorphous titania to crystalline anatase and gives the structure a hollow morphology. The TiO2 webs are thoroughly characterized using electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy to give new insight into manufacturing of porous titanium dioxide structures by means of template-based methods...
November 2, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/27805281/moderate-to-vigorous-physical-activity-but-not-sedentary-time-is-associated-with-musculoskeletal-health-outcomes-in-a-cohort-of-australian-middle-aged-women
#17
Feitong Wu, Karen Wills, Laura L Laslett, Brian Oldenburg, Graeme Jones, Tania Winzenberg
Associations between physical activity and time spent sedentary and musculoskeletal outcomes remain unclear in middle-aged adults. This study aimed to describe associations between objectively-measured physical activity and sedentary time and musculoskeletal health outcomes in middle-aged women. This cross-sectional study from a population-based sample of 309 women (aged 36-57 years) examined associations of total physical activity (accelerometer counts/minute of wear time), and time spent sedentary, in light and moderate-to-vigorous physical activities (MVPA) (by Actigraph GT1M accelerometer) with lumbar spine (LS) and femoral neck (FN) bone mineral density (BMD) (by dual-energy X-ray absorptiometry), lower limb muscle strength (LMS) and functional mobility and balance tests (timed up and go test (TUG), functional reach test (FRT), lateral reach test (LRT) and step test (ST)) using linear regression...
November 2, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27803689/naltrexone-prevents-in-males-and-attenuates-in-females-the-expression-of-behavioral-sensitization-to-ethanol-regardless-of-maternal-separation
#18
Suzi E Kawakami, Isabel M H Quadros, Deborah Suchecki
Maternal separation alters the activity of the opioid system, which modulates ethanol-induced stimulation and behavioral sensitization. This study examined the effects of an opioid antagonist, naltrexone (NTX), on the expression of behavioral sensitization to ethanol in adult male and female mice submitted to maternal separation from postnatal days (PNDs) 2 to 14. Whole litters of Swiss mice were either not separated [animal facility rearing (AFR)] or separated from their mothers for 3 h [long maternal separation (LMS)]...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27798858/molecular-pathology-and-novel-clinical-therapy-for-uterine-leiomyosarcoma
#19
REVIEW
Takuma Hayashi, Miki Kawano, Tomoyuki Ichimura, Koichi Ida, Hirofumi Ando, Dorit Zharhary, Yae Kanai, Hiroyuki Aburatani, Susumu Tonegawa, Tanri Shiozawa, Nobuo Yaegashi, Ikuo Konishi
Patients with uterine leiomyosarcoma (LMS) typically present with vaginal bleeding, pain, and a pelvic mass, with atypical presentations of hypercalcemia and eosinophilia also being reported. Radiographic evaluation with combined positron-emission tomography/computed tomography may assist in diagnosis and surveillance in women with uterine LMS; these are commonly used with stage and tumour grade as prognostic indicators and a recently developed risk-assessment index to predict disease-specific survival. Recent studies have shown that the addition of adjuvant therapy after surgical management does not seem to improve survival, and ovarian preservation does not appear to negatively impact outcome...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27796041/optimal-anesthetic-regimen-for-ambulatory-laser-microlaryngeal-surgery
#20
Hyub Huh, Seol Ju Park, Hyong Hwan Lim, Kwang Yoon Jung, Seung-Kuk Baek, Seung Zhoo Yoon, Hye Won Lee, Hye Ja Lim, Jang Eun Cho
OBJECTIVES/HYPOTHESIS: Laser microlaryngeal surgery (LMS) is a short operation requiring brief and intense paralysis. Adequate muscle relaxation and rapid recovery of neuromuscular function are essential for improving surgical conditions and reducing the incidence of complications during LMS. However, the ideal muscle relaxant with a rapid onset and short duration of action is not yet available. Rocuronium has rapid onset at higher doses, but with a prolonged duration of action. Sugammadex is a selective relaxant-binding agent that allows for rapid reversal of rocuronium-induced neuromuscular blockade...
October 31, 2016: Laryngoscope
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