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https://www.readbyqxmd.com/read/29895706/safety-and-efficacy-of-anlotinib-a-multikinase-angiogenesis-inhibitor-in-patients-with-refractory-metastatic-soft-tissue-sarcoma
#1
Yihebali Chi, Zhiwei Fang, Xiao-Nan Hong, Yang Yao, Ping Sun, Guowen Wang, Feng Du, Yongkun Sun, Qiong Wu, Guofan Qu, Shusen Wang, Jianmin Song, Jianchun Yu, Yongkui Lu, Xia Zhu, Xiaohui Niu, Zhiyong He, Jinwan Wang, Hao Yu, Jianqiang Cai
PURPOSE: The prognosis for patients with refractory soft-tissue sarcoma (STS) is dismal. Anlotinib has previously shown antitumor activity on STS in preclinical and phase I studies. EXPERIMENTAL DESIGN: Patients 18 years and older, progressing after anthracycline-based chemotherapy, naïve from angiogenesis inhibitors, with at least one measurable lesion according to RECIST 1.1, were enrolled. The main subtypes eligible were: undifferentiated pleomorphic sarcoma (UPS), liposarcoma (LPS), leiomyosarcoma (LMS), synovial sarcoma (SS), fibrosarcoma (FS), alveolar soft part sarcoma (ASPS) and clear cell sarcoma (CCS)...
June 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29887016/influence-of-mediators-on-laccase-catalyzed-radical-formation-in-lignin
#2
Line Munk, Mogens Larsen Andersen, Anne S Meyer
Laccases (EC 1.10.3.2) catalyze oxidation of phenolic groups in lignin to phenoxyl radicals during reduction of O2 to H2 O. Here, we examine the influence on this radical formation of mediators which are presumed to act by shuttling electrons between the laccase and the subunits in lignin that the enzyme cannot approach directly. Treatments of three different lignins with laccase-mediator-systems (LMS) including laccases derived from Trametes versicolor and Myceliophthora thermophila, respectively, and four individual mediators, 1-hydroxybenzotriazole (HBT), N-hydroxyphthalimide (HPI), 2,2,6,6-tetramethylpiperidin-1-yloxy (TEMPO), and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) were assessed by real time electron paramagnetic resonance measurements...
September 2018: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/29883047/a-comparative-workforce-study-of-midwives-practicing-in-the-state-of-texas
#3
Rebecca H Burpo, Priscilla M Nodine, Marie Hastings-Tolsma, Mary C Brucker, Jackie Griggs, Sarah Wilcox, Barbara D Camune, Tiffany Callahan
INTRODUCTION: Access to quality care is a problem in Texas, an ethnically diverse state with large birth numbers. The state has over 300 areas designated as medically underserved, and a severe lack of obstetricians and midwives. Minimal data exist on midwifery's contribution, and no known study compares the work environment and clinical practice of the 2 state-recognized midwifery paths, licensed midwives (LMs) and certified nurse-midwives (CNMs). The purpose of this study was to determine the differences in practice by CNMs and LMs, the latter of whom are generally certified professional midwives...
June 8, 2018: Journal of Midwifery & Women's Health
https://www.readbyqxmd.com/read/29875942/-evaluation-of-the-performance-of-the-logistics-management-system-of-malaria-control-resources-in-the-littoral-department-benin-in-2017
#4
Abdou-Rahim Ouro-Koura, Emmanuel Ghislain Sopoh, Jerôme Charles Sossa, Yolaine Glèlè-Ahanhanzo, Victoire Agueh, Edgard-Marius Ouendo, Laurent Ouedraogo
Introduction: This study aimed to evaluate the performance of the logistics management system (LMS) of malaria control (MC) resources in the Littoral Department, Benin, in 2017. Methods: In June 2017, we conducted a cross-sectional evaluative study focusing on the structures for the storage and the disposal of MC resources as well as on staff involved in their management. The performance of the the logistics management system was evaluated on the basis of the observed compliance of the components and sub-components of the "Structure", the "Process" and the "Results" with the norms and standards defined by the Ministry of Health...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29868694/meeting-the-challenge-of-instructor-shortages-a-blended-teaching-and-learning-model-for-a-neuroscience-course-in-a-doctor-of-physical-therapy-program
#5
Weiqing Ge
BACKGROUND: Physical therapy workforce shortages are expected to increase for all 50 states through 2030. There is a recognized nationwide unprecedented shortage of well-prepared physical therapy instructors. One practical solution can be to share instructors among Doctor of Physical Therapy (DPT) programs using a blended teaching and learning model. OBJECTIVE: The purpose of this project was to evaluate the effectiveness of a blended teaching and learning model for a neuroscience course in a DPT program...
2018: Journal of Allied Health
https://www.readbyqxmd.com/read/29846243/gynecological-sarcomas-what-s-new-in-2018-a-brief-review-of-published-literature
#6
Justine Gantzer, Isabelle Ray-Coquard
PURPOSE OF REVIEW: In this article, we focus on recent published data (2017) on the management of gynecologic sarcomas. RECENT FINDINGS: The most significant data published in 2017 develop definition of a new molecular subtype of high grade endometrial stromal sarcoma (ESS) using molecular technics added to histological analysis. The identification of a new translocation on presumed uterine leiomyosarcoma (LMS) points to refinement of nosological classification, with fragmentation of even rare tumors into distinct molecular entities: gynecologic sarcomas are now distinguished into distinct entities from a heterogeneous group of tumors...
July 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29845452/establishment-and-characterization-of-patient-derived-xenograft-and-its-cell-line-of-primary-leiomyosarcoma-of-bone
#7
Rieko Oyama, Mami Takahashi, Fusako Kito, Marimu Sakumoto, Kumiko Shiozawa, Zhiwei Qiao, Akihiko Yoshida, Makoto Endo, Akira Kawai, Tadashi Kondo
Primary leiomyosarcoma (LMS) of bone is a rare and aggressive mesenchymal malignancy that differentiates toward smooth muscle. Complete resection is the only curable treatment, and novel therapeutic approaches for primary LMS of bone have long been desired. Patient-derived xenografts (PDXs) and cell lines are invaluable tools for preclinical studies. Here, we established PDXs from a patient with primary LMS of bone and a cell line from an established PDX. Bone primary LMS tissue was subcutaneously implanted into highly immune-deficient mice...
May 29, 2018: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/29795952/evaluation-of-two-methods-for-modeling-measurement-errors-when-testing-interaction-effects-with-observed-composite-scores
#8
Yu-Yu Hsiao, Oi-Man Kwok, Mark H C Lai
Path models with observed composites based on multiple items (e.g., mean or sum score of the items) are commonly used to test interaction effects. Under this practice, researchers generally assume that the observed composites are measured without errors. In this study, we reviewed and evaluated two alternative methods within the structural equation modeling (SEM) framework, namely, the reliability-adjusted product indicator (RAPI) method and the latent moderated structural equations (LMS) method, which can both flexibly take into account measurement errors...
April 2018: Educational and Psychological Measurement
https://www.readbyqxmd.com/read/29789606/the-prognostic-value-of-systemic-inflammation-in-patients-undergoing-surgery-for-colon-cancer-comparison-of-composite-ratios-and-cumulative-scores
#9
Ross D Dolan, Stephen T McSorley, James H Park, David G Watt, Campbell S Roxburgh, Paul G Horgan, Donald C McMillan
INTRODUCTION: The systemic inflammatory response has been proven to have a prognostic value. There are two methods of assessing the systemic inflammatory response composite ratios (R) and cumulative scores (S). The aim of this study was to compare the prognostic value of ratios and scores in patients undergoing surgery for colon cancer. METHODS: Patients were identified prospectively in a single surgical unit. Preoperative neutrophil (N), lymphocyte (L), monocyte (M) and platelet (P) counts, CRP (C) and albumin (A) levels were recorded...
May 23, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29785174/communication-in-mental-health-nursing-bachelor-students-appraisal-of-a-blended-learning-training-programme-an-exploratory-study
#10
Merete Furnes, Kari Sofie Kvaal, Sevald Høye
Background: It is important that mental health nursing students at Bachelor level obtain effective communication skills. Many students dread the fact that in the mental health field they will encounter patients and relatives with various backgrounds and personalities. Large classes and limited teaching resources in nursing education are challenging. To prepare students for mental health nursing practice, a communication skills course based on the blended learning method was developed and carried out at two different campuses...
2018: BMC Nursing
https://www.readbyqxmd.com/read/29784970/association-of-blood-pressure-with-fasting-blood-glucose-levels-in-northeast-china-a-cross-sectional-study
#11
Yaogai Lv, Yan Yao, Junsen Ye, Xin Guo, Jing Dou, Li Shen, Anning Zhang, Zhiqiang Xue, Yaqin Yu, Lina Jin
Hypertension and diabetes mellitus (DM) have become major public health issues, and previous studies have shown that there is an association between hypertension and DM. However, there is a lack of detailed information about this association. This study aimed to explore how different blood pressure (BP) levels were associated with fasting blood glucose (FBG) levels. A cross-sectional survey with adults aged 18 to 79 years was conducted in Jilin Province, China in 2012. Lambda-mu-sigma (LMS) was used to preliminarily explore the associations of BP with FBG...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29780656/primary-leiomyosarcoma-of-the-colon-a-report-of-two-cases-review-of-the-literature-and-association-with-immunosuppression-for-ibd-and-rheumatoid-arthritis
#12
Jessica S Crystal, Kristin Korderas, David Schwartzberg, Steven C Tizio, Min Zheng, Glenn Parker
Primary leiomyosarcomas (LMS) of the colon are rare and aggressive neoplasms and have been infrequently reported in the literature. These tumors are more aggressive and have poorer prognoses than adenocarcinoma of the colon and are often mistaken as such on initial evaluation. While the former has a clear association with inflammatory bowel disease (IBD), this correlation is not known to exist with LMS and IBD. Nor is there a known link between LMS and the immunosuppression for IBD, despite the known association between malignancy and immunosuppression for other diseases...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29780335/leg-movement-activity-during-sleep-in-adults-with-attention-deficit-hyperactivity-disorder
#13
Corrado Garbazza, Cornelia Sauter, Juliane Paul, Jenny Kollek, Catharine Dujardin, Sandra Hackethal, Hans Dorn, Anita Peter, Marie-Luise Hansen, Mauro Manconi, Raffaele Ferri, Heidi Danker-Hopfe
Objectives: To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Methods: Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic sleep study. The periodic character of LMs was evaluated with established markers of "periodicity," i.e., the periodicity index, intermovement intervals, and time distribution of LM during sleep, in addition to standard parameters such as the periodic leg movement during sleep index (PLMSI) and the periodic leg movement during sleep arousal index (PLMSAI)...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29774414/tumoral-cavitation-in-colorectal-cancer-patients-with-unresectable-lung-metastasis-treated-with-bevacizumab-and-chemotherapy
#14
REVIEW
Yu Peng, Ye Chen, Xi Zhang, Yu Yang, Dan Cao, Feng Bi, Zhipi Li, Hongfeng Gou
PURPOSE: Efficacy and the frequency of tumor cavitation have not been investigated in patients with metastatic colorectal cancer (mCRC) and lung metastases (LMs) treated with chemotherapy in combination with bevacizumab. This study was aimed to evaluate the efficacy and safety of bevacizumab for unresectable mCRC with LM and to determine the frequency of tumor cavitation, and its correlation with clinical outcomes in patients receiving bevacizumab plus chemotherapy. METHODS: Patients with mCRC and LMs treated with bevacizumab as first- or second-line therapy at West China Hospital, Sichuan University Cancer Center from September 2010 to November 2016 were included in this retrospective study...
May 17, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29769749/reference-values-for-body-composition-and-associations-with-blood-pressure-in-kenyan-adults-aged-%C3%A2-50-years-old
#15
Madeleine C Bastawrous, Carmen Piernas, Andrew Bastawrous, Jason Oke, Daniel Lasserson, Wanjiku Mathenge, Matthew J Burton, Susan A Jebb, Hannah Kuper
BACKGROUND/OBJECTIVES: To develop age- and sex-specific centile reference curves for fat-free mass (FFM) and fat mass (FM) adjusted for height in an adult Kenyan population and to investigate the association between FM, FFM and blood pressure (BP). SUBJECTS/METHODS: Measures of body composition from bioimpedance analyses and BP were collected in 1995 participants aged ≥50 years in Nakuru County, Kenya. Reference curves were produced using the LMS method. Multivariable linear regression models were used to test the cross-sectional association between body composition indexes and BP...
May 15, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29765081/new-birthweight-percentiles-by-sex-and-gestational-age-in-southern-china-and-its-comparison-with-the-intergrowth-21st-standard
#16
Fei Yao, Huazhang Miao, Bing Li, Yuntao Wu, Qingguo Zhao
We first showed the sex- and gestational age (week)-specific birthweight distributions from primiparous and multiparous mothers. Birthweight percentiles were created by using the Lambda Mu Sigma (LMS) method. We established the birthweight percentiles in Southern China and provide clinicians and researchers with up-to-date population norms of birthweight percentiles. Then we use the data from Birth Certificate System between Jan 1st, 2017 and Oct 31st, 2017, which included 1,245,364 live births to calculate SGA and LGA ratio by these three birthweight references- the new INTERGROWTH-21st standard, China's 2015 research standard and our birthweight percentiles...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29763687/therapeutic-efficacy-of-lipid-emulsions-of-docetaxel-linoleic-acid-conjugate-in-breast-cancer
#17
Tao Zhang, Meng Li, Ruyi Yang, Dong Zhang, Jibin Guan, Jiang Yu, Bin Yang, Huicong Zhang, Shenwu Zhang, Dan Liu, Yongjun Wang
Docetaxel (DTX) solution is among the most widely-used parenteral formulations used in advanced breast cancer therapy. However, severe side effects have been observed due to the use of ethanol and polysorbate 80. Herein, a novel DTX-based prodrug, docetaxel-linoleic acid conjugate (DTX-LA) was successfully synthesized. The high lipid solubility of DTX and DTX-LA resulted in a tendency for them to become entrapped in the oil core of the emulsions. As anticipated, nano-sized, sterically stabilized oil-in-water lipid emulsions (LMs) of DTX-LA LMs and DTX LMs were successfully constructed...
May 12, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29763661/prominent-release-of-lipoxygenase-generated-mediators-in-a-murine-house-dust-mite-induced-asthma-model
#18
Johan Kolmert, Sergio Piñeiro-Hermida, Craig E Wheelock, Mats Hamberg, Joshua A Gregory, Icíar P López, Alexander Fauland, Sven-Erik Dahlén, José G Pichel, Mikael Adner
The profile of activation of lipid mediator (LM) pathways in asthmatic airway inflammation remains unclear. This experimental study quantified metabolite levels of ω3-, ω6- and ω9-derived polyunsaturated fatty acids in bronchoalveolar lavage fluid (BALF) after 4-weeks of repeated house dust mite (HDM) exposure in a murine (C57BL/6) asthma model. The challenge induced airway hyperresponsiveness, pulmonary eosinophil infiltration, but with low and unchanged mast cell numbers. Of the 112 screened LMs, 26 were increased between 2 to >25-fold in BALF with HDM treatment (p < 0...
May 12, 2018: Prostaglandins & Other Lipid Mediators
https://www.readbyqxmd.com/read/29748702/serum-renalase-levels-in-adolescents-with-primary-hypertension
#19
Marta Lemiesz, Edyta Tenderenda-Banasiuk, Dorota Sosnowska, Katarzyna Taranta-Janusz, Anna Wasilewska
The prevalence of hypertension in pediatric populations continues to rise. Recent studies suggest that renalase plays an important role in blood pressure regulation. The aim of this study was to evaluate serum renalase concentrations in hypertensive children. This study was a prospective cohort analysis of 88 adolescents (40 girls; 48 boys) aged 11-18 years, divided into two groups: HT-38 subjects with primary hypertension; and R (reference group)-50 subjects with normal blood pressure. Serum renalase concentration was measured using a commercial enzyme-linked immunosorbent assay kit...
May 10, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29745805/patterns-of-accelerometer-derived-sedentary-time-across-the-lifespan
#20
Diana A Santos, Pedro B Júdice, João P Magalhães, Inês R Correia, Analiza M Silva, Fátima Baptista, Luís B Sardinha
We aimed to describe ST and its patterns on a national level. A hip-worn accelerometer (ActiGraph GT1M) was used to collect data during waking hours from 4575 Portuguese' participants from 2007-2009 (2683 females) aged 10-102 years old. Data was presented by sex, in 5-years age intervals, and by adolescents (n=2833), adults (n=1122), and older adults (n=620). Lambda-mu-sigma (LMS) smoothed percentile curves were estimated. Girls, women, and older women spent 61, 57, and 64% of wear time in ST, respectively...
May 10, 2018: Journal of Sports Sciences
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