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https://www.readbyqxmd.com/read/28930806/management-of-leimyosarcoma-a-survey-among-members-of-the-korean-gynecologic-oncology-group
#1
Mi Kyoung Kim, Taek Sang Lee, Jae-Weon Kim, Jong-Min Lee, Beob Jong Kim, Seok Ju Seong
OBJECTIVE: This study aimed to investigate current clinical management of leiomyosarcoma (LMS) in Korea. MATERIALS AND METHODS: We conducted a Web-based survey among members of the Korean Gynecologic Oncology Group regarding their treatment of LMS. RESULTS: In total, 77 (27.8%) of 277 members responded to the survey. For surgical treatment of stage I LMS, 26.8% indicated total hysterectomy only and 16.9% indicated total hysterectomy with bilateral salpingo-oophorectomy...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28920993/cobalt-ii-containing-liquid-metal-salts-for-electrodeposition-of-cobalt-and-electrochemical-nanoparticle-formation
#2
Jeroen Sniekers, Pieter Geysens, João C Malaquías, Tom Vander Hoogerstraete, Luc Van Meervelt, Jan Fransaer, Koen Binnemans
Cobalt(ii)-containing liquid metal salts (LMS) with N-alkylimidazole ligands and bis(trifluoromethanesulfonyl)imide (bistriflimide, Tf2N(-)) or methanesulfonate (mesylate, OMs(-)) anions were synthesized and characterized. The chain length of the alkyl side chain on the imidazole ligand was varied. All compounds were characterized using CHN analysis, DSC and FTIR measurements. Single-crystal X-ray diffraction measurements were performed on six of the compounds for which single crystals of good quality could be obtained...
September 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28893868/official-ers-technical-standards-global-lung-function-initiative-reference-values-for-the-carbon-monoxide-transfer-factor-for-caucasians
#3
Sanja Stanojevic, Brian L Graham, Brendan G Cooper, Bruce R Thompson, Kim W Carter, Richard W Francis, Graham L Hall
There are numerous reference equations available for the single-breath transfer factor of the lung for carbon monoxide (T LCO); however, it is not always clear which reference set should be used in clinical practice. The aim of the study was to develop the Global Lung Function Initiative (GLI) all-age reference values for T LCOData from 19 centres in 14 countries were collected to define T LCO reference values. Similar to the GLI spirometry project, reference values were derived using the LMS (lambda, mu, sigma) method and the GAMLSS (generalised additive models for location, scale and shape) programme in R...
September 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/28884903/long-term-follow-up-of-lymphatic-malformations-in-children-treated-with-sildenafil
#4
Joanna H Tu, Elidia Tafoya, Michael Jeng, Joyce M Teng
BACKGROUND/OBJECTIVES: Lymphatic malformations (LMs) are challenging to treat. Reports on the benefits of sildenafil for LM management have been mixed. This study evaluated long-term clinical outcomes of pediatric LM patients after sildenafil treatment. METHODS: A retrospective chart review was performed on pediatric LM patients treated with sildenafil in the past 5 years. Patients were also contacted to complete a survey of comprehensive questions about their LM after sildenafil and subsequent interventions...
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28879765/transfer-of-materials-from-water-to-solid-surfaces-by-using-liquid-marbles
#5
Hisato Kawashima, Maxime Paven, Hiroyuki Mayama, Hans-Jürgen Butt, Yoshinobu Nakamura, Syuji Fujii
Remotely controlling the movement of small objects is desirable, especially for the transportation and selection of materials. Transfer of the objects between liquid and solid surfaces and triggering their release would allow for development of novel material transportation technology. Here, we describe the remote transport of a material from a water film surface to a solid surface by using quasi-spherical liquid marbles (LMs). A light-induced Marangoni flow or an air stream is used to propel the LMs on water...
September 7, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28879671/manipulation-of-biomolecules-modified-liquid-metal-blobs
#6
Yue Yu, Eijiro Miyako
Soft and deformable liquid metals (LMs) are building components in various systems related to uncertain- and dynamic task-environments. Here we develop a biomolecule-triggered external manipulation method involving LM conjugates for constructing future innovative soft robotics operating under physiological environments. Functional soft hybrids composed of an LM droplet, a thiolated ligand, and proteins are synthesized for the expression of diverse macroscopic commands such as attachment on cells, binary fusion, and self-propelled movement via molecular recognitions and enzymatic reaction...
September 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28869928/atypical-uterine-smooth-muscle-tumors-a-retrospective-evaluation-of-clinical-and-pathologic-features
#7
Giuseppa Maltese, Caterina Fontanella, Stefano Lepori, Cono Scaffa, Giovanni Fucà, Giorgio Bogani, Salvatore Provenzano, Maria Luisa Carcangiu, Francesco Raspagliesi, Domenica Lorusso
BACKGROUND: Clinical characteristics combined with new biomarkers help discriminate between atypical uterine smooth muscle tumors (AUSMT) and leiomyosarcomas (LMS). PATIENTS AND METHODS: We retrospectively collected a series of leiomyomas (LM), AUSMT, and LMS. Estrogen receptors (ER), progesterone receptors (PR), p16, Ki-67, and p53 expression were assessed by immunohistochemistry. For AUSMT patients, immunohistochemistry evaluations were performed at the time of diagnosis and at recurrences...
September 5, 2017: Oncology
https://www.readbyqxmd.com/read/28865875/photochemical-internalization-pci-of-bleomycin-is-equally-effective-in-two-dissimilar-leiomyosarcoma-xenografts-in-athymic-mice
#8
Simen Sellevold, Qian Peng, Ane Sofie Viset Fremstedal, Kristian Berg
BACKGROUND: Photochemical internalization (PCI) is a novel technique for delivery of active macromolecules into cancerous cells, via light activation of a specific photosensitizer and a low dose systemic drug. Numerous pre-clinical studies and one clinical trial have confirmed the treatment potential in carcinomas. Soft tissue sarcomas are rare and generally resistant to radio- and chemotherapy. Due to treatment resistance and surgical morbidity in sarcoma care, we seek to increase knowledge on PCI effects in sarcomas by studying two different, but closely related leiomyosarcomas...
August 30, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28843558/targeted-quantification-of-lipid-mediators-in-skeletal-muscles-using-restricted-access-media-based-trap-and-elute-liquid-chromatography-mass-spectrometry
#9
Zhiying Wang, Liangqiao Bian, Chenglin Mo, Maciej Kukula, Kevin A Schug, Marco Brotto
Lipid mediators (LMs) are a class of bioactive metabolites of the essential polyunsaturated fatty acids (PUFA), which are involved in many physiological processes. Their quantification in biological samples is critical for understanding their functions in lifestyle and chronic diseases, such as diabetes, as well allergies, cancers, and in aging processes. We developed a rapid, and sensitive LC-MS/MS method to quantify the concentrations of 14 lipid mediators of interest in mouse skeletal muscle tissue without time-consuming liquid-liquid or solid-phase extractions...
September 1, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28838761/impact-of-genotypic-and-phenotypic-differences-in-sarcoma-models-on-the-outcome-of-photochemical-internalization-pci-of-bleomycin
#10
Cathrine Elisabeth Olsen, Simen Sellevold, Theodossis Theodossiou, Sebastian Patzke, Kristian Berg
The low curative response to current treatment regimens for most soft tissue sarcomas indicates a strong need for alternative treatment strategies and predictive markers for treatment outcome. PCI (photochemical internalization) is a novel treatment strategy to translocate drugs into cytosol that otherwise would have been degraded in lysosomes. Two highly geno-and phenotypically different uterine and vulvar leiomyosarcoma cell lines, MES-SA and SK-LMS-1, were treated with bleomycin (BLM) activated by PCI (PCIBLM)...
August 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28837798/lymphotoxins-promote-the-progression-of-human-lymphatic-malformation-by-enhancing-lymphatic-endothelial-cell-proliferation
#11
Jie-Gang Yang, Yan-Fang Sun, Ke-Fei He, Jian-Gang Ren, Zhuo-Jue Liu, Bing Liu, Wei Zhang, Yi-Fang Zhao
Formation of inflammation-related tertiary lymphoid organs promotes human lymphatic malformation (LM) development. However, the role of lymphotoxins (LTs) and LT-related inducible ligand, the crucial mediators for tertiary lymphoid organ formation, is undetermined in LMs. Herein, we show that LTs and LT-related inducible ligand promote LM development by enhancing lymphatic endothelial cell (LEC) proliferation via activating NF-κB pathways. The expression of LTs and their receptors was increased in LMs, especially the infected ones, when compared with normal skins...
August 21, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28835316/plane-of-nutrition-during-the-rearing-phase-for-replacement-ewes-of-four-genotypes-i-effects-on-growth-and-development-and-on-ovulation-rate-at-first-joining
#12
T W J Keady, J P Hanrahan
Plane of nutrition (PN) offered to ewe replacements during the rearing phase (8 to 17 months) affects BW at joining and may affect reproductive performance when joined at ~19 months. The effects of PN offered to ewe replacements during their first winter (winter_1) and second summer (summer_2) were evaluated over 3 consecutive years, using 287 spring-born ewe lambs, representing four genotypes (Belclare (Bel), Charmoise×Scottish Blackface (C×SBF), Bel×SBF (Bel×SBF), Bel×SBF that were heterozygous either FecGH or FecXG mutations that increase ovulation rate (OR) (BelMG×SBF))...
August 24, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28834841/lymphatic-malformation-architecture-implications-for-treatment-with-ok-432
#13
Claudia C Malic, Regan Guilfoyle, Rebecca J M Courtemanche, Jugpal S Arneja, Manraj K S Heran, Douglas J Courtemanche
PURPOSE: Herein, the authors aim to describe their findings of novel architectural types of lymphatic malformations (LM) and explain the relationship between these architectures and OK-432 treatment outcomes. METHODS: A retrospective review was conducted of all patients diagnosed with a LM treated with OK-432 at the Vascular Anomalies Clinic at BC Children's Hospital from December 2002 to January 2012. RESULTS: Twenty-seven patients were included in the study...
August 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28820478/detection-of-interactions-between-proteins-by-using-legendre-moments-descriptor-to-extract-discriminatory-information-embedded-in-pssm
#14
Yan-Bin Wang, Zhu-Hong You, Li-Ping Li, Yu-An Huang, Hai-Cheng Yi
Protein-protein interactions (PPIs) play a very large part in most cellular processes. Although a great deal of research has been devoted to detecting PPIs through high-throughput technologies, these methods are clearly expensive and cumbersome. Compared with the traditional experimental methods, computational methods have attracted much attention because of their good performance in detecting PPIs. In our work, a novel computational method named as PCVM-LM is proposed which combines the probabilistic classification vector machine (PCVM) model and Legendre moments (LMs) to predict PPIs from amino acid sequences...
August 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28818226/percutaneous-ultrasound-guided-sclerotherapy-with-polidocanol-microfoam-for-lymphatic-malformations
#15
Takashi Yamaki, Yumiko Sasaki, Yuki Hasegawa, Atsuyoshi Osada, Hisato Konoeda, Atsumori Hamahata, Motohiro Nozaki, Hiroyuki Sakurai
BACKGROUND: Lymphatic malformations (LMs) are low-flow congenital lesions that consist of cysts of varying size. Sclerotherapy with intralesional bleomycin and OK-432 has been reported to yield dramatically beneficial results for this disorder. However, inflammation-related symptoms are often seen after treatment with these sclerosing agents. On the other hand, polidocanol (POL) is reportedly associated with fewer allergic and inflammatory reactions. Up to now, however, very few reports have documented the use of POL microfoam for treatment of LMs...
September 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28810590/diagnosis-and-surgical-treatment-of-cervical-macrocystic-lymphatic-malformations-in-infants
#16
Jing Ma, Ruan Biao, Fan Lou, Ken Lin, Ying-Qin Gao, Mei-Lan Wang, Yan-Li Yang, Tie-Song Zhang
The treatment of lymphatic malformations (LMs) represents a great clinical challenge. The present study reported on the treatment of 68 infants with cervical macrocystic LMs using surgical resection. The cases were retrospectively analyzed. All patients underwent pre-operative ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI) examinations. The surgery was performed under general anesthesia with endotracheal intubation. Ultrasonograms showed that 24 cases were monolocular, 44 were multilocular, 16 had no echo, 20 had a uniform low-level echo and 32 had a non-uniform low-level echo...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809923/generalized-structural-equations-improve-sexual-selection-analyses
#17
Sonia Lombardi, Giacomo Santini, Giovanni Maria Marchetti, Stefano Focardi
Sexual selection is an intense evolutionary force, which operates through competition for the access to breeding resources. There are many cases where male copulatory success is highly asymmetric, and few males are able to sire most females. Two main hypotheses were proposed to explain this asymmetry: "female choice" and "male dominance". The literature reports contrasting results. This variability may reflect actual differences among studied populations, but it may also be generated by methodological differences and statistical shortcomings in data analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28782106/sirolimus-as-treatment-for-19-patients-with-refractory-cervicofacial-lymphatic-malformation
#18
Julie E Strychowsky, Reza Rahbar, Meghan J O'Hare, Alexandria L Irace, Horacio Padua, Cameron C Trenor
OBJECTIVE: Lymphatic malformations (LMs) are challenging to manage, particularly those involving the cervicofacial region and airway. Traditional therapy is sclerotherapy and/or resection. We aim to establish the emerging therapeutic role of sirolimus. STUDY DESIGN: Institutional review board-approved retrospective review. METHODS: All patients treated for cervicofacial LM with sirolimus at Boston Children's Hospital, Massachusetts, from November 2012 to October 2016 were included...
August 7, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28774362/-intrauterine-growth-curves-for-body-weight-body-length-head-circumference-chest-circumference-and-crown-rump-length-in-16%C3%A2-887-neonates-with-a-gestational-age-of-27-42-weeks-in-shenzhen-china
#19
Xiao-Yun Huang, Hui-Long Liu, Min Lei, Hui-Fen Mai, Chao-Hui Lian, You-Cong Li
OBJECTIVE: To establish the intrauterine growth curves of neonates in Shenzhen, China and to investigate the intrauterine growth of neonates in Shenzhen. METHODS: Cross-sectional cluster sampling was performed for an on-the-spot investigation of 16 887 neonates (9 418 males and 7 469 females) with a gestational age of 27-42 weeks who were born in two hospitals in Shenzhen from April 2013 to September 2015. The Lambda Mu Sigma (LMS) method was used for the curve fitting of body weight, body length, head circumference, chest circumference, and crown-rump length...
August 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28765512/a-cluster-of-immunoresolvents-links-coagulation-to-innate-host-defense-in-human-blood
#20
Paul C Norris, Stephania Libreros, Nan Chiang, Charles N Serhan
Blood coagulation is a protective response that prevents excessive bleeding upon blood vessel injury. We investigated the relationship between coagulation and the resolution of inflammation and infection by lipid mediators (LMs) through metabololipidomics-based profiling of human whole blood (WB) during coagulation. We identified temporal clusters of endogenously produced prothrombotic and proinflammatory LMs (eicosanoids), as well as specialized proresolving mediators (SPMs). In addition to eicosanoids, a specific SPM cluster was identified that consisted of resolvin E1 (RvE1), RvD1, RvD5, lipoxin B4, and maresin 1, each of which was present at bioactive concentrations (0...
August 1, 2017: Science Signaling
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