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B Kiec-Wilk, U Razny, J C Mathers, A Dembinska-Kiec
UNLABELLED: DNA methylation is a potent regulator of gene expression. The influence of beta-carotene (BC) and arachidonic acid (AA) on angiogenesis--a new blood vessel formation, was reported. The tyrosine kinase VEGFR-2 receptor (KDR) activation by vascular endothelial growth factor is one of the main angiogenic mechanisms. This study was aimed to investigate a possible role of CpG island methylation on regulation of the pro-angiogenic KDR gene expression after incubation of human endothelial cells with BC and/or AA...
December 2009: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
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