Jinlong Wei, Kejun Du, Qinzhen Cai, Lisha Ma, Zhenzhen Jiao, Jinrong Tan, Zhou Xu, Jingxia Li, Wenjin Luo, Jingyuan Chen, Jimin Gao, Dongyun Zhang, Chuanshu Huang
Epidemiologic studies have provided solid evidence for the neurotoxic effect of lead for decades of years. In view of the fact that children are more vulnerable to the neurotoxicity of lead, lead exposure has been an urgent public health concern. The modes of action of lead neurotoxic effects include disturbance of neurotransmitter storage and release, damage of mitochondria, as well as induction of apoptosis in neurons, cerebrovascular endothelial cells, astroglia and oligodendroglia. Our studies here, from a novel point of view, demonstrates that lead specifically caused induction of COX-2, a well known inflammatory mediator in neurons and glia cells...
November 5, 2014: Toxicology