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NFAT glia

María C Serrano-Pérez, Miriam Fernández, Fernando Neria, Mónica Berjón-Otero, Ernesto Doncel-Pérez, Eva Cano, Pedro Tranque
The study of factors that regulate the survival, proliferation, and differentiation of neural precursor cells (NPCs) is essential to understand neural development as well as brain regeneration. The Nuclear Factor of Activated T Cells (NFAT) is a family of transcription factors that can affect these processes besides playing key roles during development, such as stimulating axonal growth in neurons, maturation of immune system cells, heart valve formation, and differentiation of skeletal muscle and bone. Interestingly, NFAT signaling can also promote cell differentiation in adults, participating in tissue regeneration...
June 2015: Glia
Jinlong Wei, Kejun Du, Qinzhen Cai, Lisha Ma, Zhenzhen Jiao, Jinrong Tan, Zhou Xu, Jingxia Li, Wenjin Luo, Jingyuan Chen, Jimin Gao, Dongyun Zhang, Chuanshu Huang
Epidemiologic studies have provided solid evidence for the neurotoxic effect of lead for decades of years. In view of the fact that children are more vulnerable to the neurotoxicity of lead, lead exposure has been an urgent public health concern. The modes of action of lead neurotoxic effects include disturbance of neurotransmitter storage and release, damage of mitochondria, as well as induction of apoptosis in neurons, cerebrovascular endothelial cells, astroglia and oligodendroglia. Our studies here, from a novel point of view, demonstrates that lead specifically caused induction of COX-2, a well known inflammatory mediator in neurons and glia cells...
November 5, 2014: Toxicology
Susana Alvarez, Almudena Blanco, Manuel Fresno, Ma Ángeles Muñoz-Fernández
There is increasing evidence that soluble factors in inflammatory central nervous system diseases not only regulate the inflammatory process but also directly influence electrophysiological membrane properties of neurons and astrocytes. In this context, the cytokine TNF-α (tumor necrosis factor-α) has complex injury promoting, as well as protective, effects on neuronal viability. Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well...
January 27, 2011: PloS One
Hafiz Mohmmad Abdul, Jennifer L Furman, Michelle A Sama, Diana M Mathis, Christopher M Norris
Nuclear factor of activated T cells (NFAT) is a transcription factor that translocates from cytosol to nucleus following dephosphorylation by the Ca(2+)/calmodulin dependent protein phosphatase calcineurin (CN). In nervous tissue, aberrant CN signaling is increasingly linked to a variety of pathologic features associated with Alzheimer's disease (AD), including synaptic dysfunction, glial activation, and neuronal death. Consistent with this linkage, our recent work on postmortem human hippocampal tissue discovered increased nuclear accumulation of select NFAT isoforms at different stages of AD...
January 1, 2010: Molecular and Cellular Pharmacology
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