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https://www.readbyqxmd.com/read/29332366/molecular-landscape-in-laryngeal-chondrosarcoma
#1
Eleftheria Gletsou, Panagiotis P Fotiades, Evangelos Tsiambas, Vasileios Ragos
No abstract text is available yet for this article.
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29332359/novel-molecular-and-metabolic-aspects-in-osteosarcoma
#2
Evangelos Tsiambas, Panagiotis P Fotiades, Chrissa Sioka, Dimitrios Kotrotsios, Evangelia Gkika, Andreas Fotopoulos, Stylianos N Mastronikolis, Ilianna E Armata, Evangelos Giotakis, Vasileios Ragos
Osteosarcoma (OS) is the most frequent bone-forming malignancy in children and adolescents. Concerning its molecular landscape, there is no a direct relationship with a specific gene, but a combination of genetic events. A broad spectrum of activated oncogenes and downregulated suppressor genes has been already explored and considered crucial for its progressive pathogenesis. Mechanisms of gene deregulation include amplifications, point mutations, allelic losses and also epigenetic abnormalities such as aberrant promoter methylation...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331944/liver-sampling-a-vital-window-into-hbv-pathogenesis-on-the-path-to-functional-cure
#3
REVIEW
Upkar S Gill, Laura J Pallett, Patrick T F Kennedy, Mala K Maini
In order to optimally refine the multiple emerging drug targets for hepatitis B virus (HBV), it is vital to evaluate virological and immunological changes at the site of infection. Traditionally liver biopsy has been the mainstay of HBV disease assessment, but with the emergence of non-invasive markers of liver fibrosis, there has been a move away from tissue sampling. Here we argue that liver biopsy remains an important tool, not only for the clinical assessment of HBV but also for research progress and evaluation of novel agents...
January 13, 2018: Gut
https://www.readbyqxmd.com/read/29331835/integrating-priority-areas-and-ecological-corridors-into-national-network-for-conservation-planning-in-china
#4
Jie Liang, Xinyue He, Guangming Zeng, Minzhou Zhong, Xiang Gao, Xin Li, Xiaodong Li, Haipeng Wu, Chunting Feng, Wenle Xing, Yilong Fang, Dan Mo
Considering that urban expansion and increase of human activities represent important threats to biodiversity and ecological processes in short and long term, developing protected area (PA) network with high connectivity is considered as a valuable conservation strategy. However, conservation planning associated with the large-scale network in China involves important information loopholes about the land cover and landscape connectivity. In this paper, we made an integrative analysis for the identification of conservation priority areas and least-cost ecological corridors (ECs) in order to promote a more representative, connected and efficient ecological PA network for this country...
January 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29331137/molecular-dynamics-based-enhanced-sampling-of-collective-variables-with-very-large-time-steps
#5
Pei-Yang Chen, Mark E Tuckerman
Enhanced sampling techniques that target a set of collective variables and that use molecular dynamics as the driving engine have seen widespread application in the computational molecular sciences as a means to explore the free-energy landscapes of complex systems. The use of molecular dynamics as the fundamental driver of the sampling requires the introduction of a time step whose magnitude is limited by the fastest motions in a system. While standard multiple time-stepping methods allow larger time steps to be employed for the slower and computationally more expensive forces, the maximum achievable increase in time step is limited by resonance phenomena, which inextricably couple fast and slow motions...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29331121/diffusion-of-a-particle-in-the-spatially-correlated-exponential-random-energy-landscape-transition-from-normal-to-anomalous-diffusion
#6
S V Novikov
Diffusive transport of a particle in a spatially correlated random energy landscape having exponential density of states has been considered. We exactly calculate the diffusivity in the nondispersive quasi-equilibrium transport regime for the 1D transport model and found that for slow decaying correlation functions the diffusivity becomes singular at some particular temperature higher than the temperature of the transition to the true non-equilibrium dispersive transport regime. It means that the diffusion becomes anomalous and does not follow the usual ∝ t1/2 law...
January 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29330915/effects-of-seed-mixture-sowing-with-resistant-and-susceptible-rice-on-population-dynamics-of-target-planthoppers-and-non-target-stemborers-and-leaffolders
#7
Zhuo Li, Gui-Jun Wan, Long Wang, Megha N Parajulee, Zi-Hua Zhao, Fa-Jun Chen
BACKGROUND: The widespread planting of insect-resistant crops has caused a dramatic shift in agricultural landscapes, thus raising concerns about the potential impact on both target and non-target pests worldwide. In this study, we examined the potential effects of six seed-mixture ratios of insect-resistant dominance (100%-R100, 95%-S05R95, 90%-S10R90, 80%-S20R80, 60%-S40R60, and 0%-S100) on target and non-target pests in a 2-year field trial in southern China. RESULTS: The occurrence of target pests, Nilaparvata lugens and Sogatella furcifera, decreased with the increased ratio of resistant rice, and the mixture ratios with ≥90% resistant rice significantly increased the pest suppression efficiency, with lowest occurrences of non-target pests, Sesamia inferens, Chilo suppressalis and Cnaphalocrocis medinalis, in S100 and S10R90 seed-mixture ratios...
January 13, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29330750/immunologic-and-gene-expression-profiles-of-spontaneous-canine-oligodendrogliomas
#8
Anna Filley, Mario Henriquez, Tanmoy Bhowmik, Brij Nath Tewari, Xi Rao, Jun Wan, Margaret A Miller, Yunlong Liu, R Timothy Bentley, Mahua Dey
Malignant glioma (MG), the most common primary brain tumor in adults, is extremely aggressive and uniformly fatal. Several treatment strategies have shown significant preclinical promise in murine models of glioma; however, none have produced meaningful clinical responses in human patients. We hypothesize that introduction of an additional preclinical animal model better approximating the complexity of human MG, particularly in interactions with host immune responses, will bridge the existing gap between these two stages of testing...
January 12, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29330617/characterizing-genomic-differences-of-human-cancer-stratified-by-the-tp53-mutation-status
#9
Mengyao Wang, Chao Yang, Xiuqing Zhang, Xiangchun Li
The key roles of the TP53 mutation in cancer have been well established. TP53 is the most frequently mutated gene, and its inactivation is widespread among human cancer types. However, the landscape of genomic alterations in human cancers stratified by the TP53 mutation has not yet been described. We obtained somatic mutation and copy number change data of 6551 regular-mutated samples from the Cancer Genome Atlas (TCGA) and compared significantly mutated genes (SMGs), copy number alterations, mutational signatures and mutational strand asymmetries between cancer samples with and without the TP53 mutation...
January 12, 2018: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/29330292/microenvironmental-derived-regulation-of-hif-signaling-drives-transcriptional-heterogeneity-in-glioblastoma-multiforme
#10
Dieter Henrik Heiland, Annette Gaebelein, Melanie Boerries, Jakob Woerner, Nils Pompe, Pamela Franco, Sabrina Heynckes, Mark D Bartholomä, Darren Ó hAilín, Maria Stella Carro, Marco Prinz, Stefan Weber, Irina Mader, Daniel Delev, Oliver Schnell
The evolving and highly heterogeneous nature of malignant brain tumors underlies their limited response to therapy and poor prognosis. In addition to genetic alterations, highly dynamic processes such as transcriptional and metabolic reprogramming play an important role in the development of tumor heterogeneity. The present study reports an adaptive mechanism in which the metabolic environment of malignant glioma drives transcriptional reprogramming. Multi-regional analysis of a glioblastoma patient biopsy revealed a metabolic landscape marked by varying stages of hypoxia and creatine enrichment...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29330264/ependymoma-superenhancer-profiling-reveals-potential-therapeutic-targets
#11
(no author information available yet)
Ependymoma superenhancer landscapes delineate molecular subgroups and define transcriptional circuitries.
January 12, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29330140/exploring-entertainment-medicine-and-professionalization-of-self-care-interview-study-among-doctors-on-the-potential-effects-of-digital-self-tracking
#12
Katleen Gabriels, Tania Moerenhout
BACKGROUND: Nowadays, digital self-tracking devices offer a plethora of possibilities to both healthy and chronically ill users who want to closely examine their body. This study suggests that self-tracking in a private setting will lead to shifting understandings in professional care. To provide more insight into these shifts, this paper seeks to lay bare the promises and challenges of self-tracking while staying close to the everyday professional experience of the physician. OBJECTIVE: The aim of this study was to (1) offer an analysis of how medical doctors evaluate self-tracking methods in their practice and (2) explore the anticipated shifts that digital self-care will bring about in relation to our findings and those of other studies...
January 12, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29329512/landscape-and-rodent-community-composition-are-associated-with-risk-of-hemorrhagic-fever-with-renal-syndrome-in-two-cities-in-china-2006-2013
#13
Hong Xiao, Xin Tong, Ru Huang, Lidong Gao, Shixiong Hu, Yapin Li, Hongwei Gao, Pai Zheng, Huisuo Yang, Zheng Y X Huang, Hua Tan, Huaiyu Tian
BACKGROUND: Hemorrhagic fever with renal syndrome (HFRS) is a rodent-borne disease caused by hantaviruses. Landscape can influence the risk of hantavirus infection for humans, mainly through its effect on rodent community composition and distribution. It is important to understand how landscapes influence population dynamics for different rodent species and the subsequent effect on HFRS risk. METHODS: To determine how rodent community composition influenced human hantavirus infection, we monitored rodent communities in the prefecture-level cities of Loudi and Shaoyang, China, from 2006 to 2013...
January 12, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29329374/simulate-simulating-complex-landscapes-of-transposable-elements-of-populations
#14
Robert Kofler
No abstract text is available yet for this article.
January 9, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29329190/landscape-of-living-multi-organ-donation-in-the-united-states-a-registry-based-cohort-study
#15
Macey L Henderson, Sandra R DiBrito, Alvin G Thomas, Courtenay M Holscher, Ashton A Shaffer, Mary Grace Bowring, Tanjala S Purnell, Allan B Massie, Jacqueline Garonzik-Wang, Madeleine Waldram, Krista L Lentine, Dorry L Segev
BACKGROUND: The donation of multiple allografts from a single living donor is a rare practice, and the patient characteristics and outcomes associated with these procedures are not well described. METHODS: Using the SRTR registry, we identified 101 living multi-organ donors and their 133 recipients. RESULTS: The 49 sequential (donations during separate procedures) multi-organ donors provided grafts to 81 recipients: 21 kidney-then-liver, 15 liver-then-kidney, 5 lung-then-kidney, 3 liver-then-intestine, 3 kidney-then-pancreas, 1 lung-then-liver, and 1 pancreas-then-kidney...
January 11, 2018: Transplantation
https://www.readbyqxmd.com/read/29329112/master-protocols-in-lung-cancer-experience-from-lung-master-protocol
#16
Vincent K Lam, Vassiliki Papadimitrakopoulou
PURPOSE OF REVIEW: Contemporary advances in the understanding of the molecular and immunologic basis of metastatic lung cancer have firmly changed its treatment paradigm to a personalized, biomarker-driven approach. However, the majority of lung-cancer patients [especially lung squamous cell carcinoma (LUSC)] still do not have effective targeted therapeutic options. Master protocols, such as Lung-MAP, represent an innovative clinical trial approach designed to accelerate evaluation of novel biomarker-driven therapies...
January 10, 2018: Current Opinion in Oncology
https://www.readbyqxmd.com/read/29329003/modified-forest-rotation-lengths-long-term-effects-on-landscape-scale-habitat-availability-for-specialized-species
#17
Jean-Michel Roberge, Karin Öhman, Tomas Lämås, Adam Felton, Thomas Ranius, Tomas Lundmark, Annika Nordin
We evaluated the long-term implications from modifying rotation lengths in production forests for four forest-reliant species with different habitat requirements. By combining simulations of forest development with habitat models, and accounting both for stand and landscape scale influences, we projected habitat availability over 150 years in a large Swedish landscape, using rotation lengths which are longer (+22% and +50%) and shorter (-22%) compared to current practices. In terms of mean habitat availability through time, species requiring older forest were affected positively by extended rotations, and negatively by shortened rotations...
January 9, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29328912/bcg-educates-hematopoietic-stem-cells-to-generate-protective-innate-immunity-against-tuberculosis
#18
Eva Kaufmann, Joaquin Sanz, Jonathan L Dunn, Nargis Khan, Laura E Mendonça, Alain Pacis, Fanny Tzelepis, Erwan Pernet, Anne Dumaine, Jean-Christophe Grenier, Florence Mailhot-Léonard, Eisha Ahmed, Jad Belle, Rickvinder Besla, Bruce Mazer, Irah L King, Anastasia Nijnik, Clinton S Robbins, Luis B Barreiro, Maziar Divangahi
The dogma that adaptive immunity is the only arm of the immune response with memory capacity has been recently challenged by several studies demonstrating evidence for memory-like innate immune training. However, the underlying mechanisms and location for generating such innate memory responses in vivo remain unknown. Here, we show that access of Bacillus Calmette-Guérin (BCG) to the bone marrow (BM) changes the transcriptional landscape of hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs), leading to local cell expansion and enhanced myelopoiesis at the expense of lymphopoiesis...
January 11, 2018: Cell
https://www.readbyqxmd.com/read/29328871/achieving-mental-health-and-substance-use-disorder-treatment-parity-a-quarter-century-of-policy-making-and-research
#19
Emma Peterson, Susan Busch
The Mental Health Parity and Addiction Equity Act (MHPAEA) of 2008 changed the landscape of mental health and substance use disorder coverage in the United States. The MHPAEA's comprehensiveness compared with past parity laws, including its extension of parity to plan management strategies, the so-called nonquantitative treatment limitations (NQTL), led to significant improvements in mental health care coverage. In this article, we review the history of this landmark legislation and its recent expansions to new populations, describe past research on the effects of this and other mental health/substance use disorder parity laws, and describe some directions for future research, including NQTL compliance issues, effects of parity on individuals with severe mental illness, and measurement of benefits other than mental health care use...
January 12, 2018: Annual Review of Public Health
https://www.readbyqxmd.com/read/29328674/new-insights-on-ecosystem-mercury-cycling-revealed-by-stable-isotopes-of-mercury-in-water-flowing-from-a-headwater-peatland-catchment
#20
Glenn Woerndle, Martin Tsz-Ki Tsui, Stephen Sebestyen, Joel D Blum, Xiangping Nie, Randall K Kolka
Stable isotope compositions of mercury (Hg) were measured in the outlet stream and in soil cores at different landscape positions in a 9.7-ha boreal upland-peatland catchment in northern Minnesota. An acidic permanganate/persulfate digestion procedure was validated for water samples with high dissolved organic matter (DOM) concentrations and we verified the complete breakdown of DOM through Hg spike addition analysis. We report a relatively large variation in mass-dependent fractionation (δ202Hg; from -2.12 to -1...
January 12, 2018: Environmental Science & Technology
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