keyword
MENU ▼
Read by QxMD icon Read
search

Architecture

keyword
https://www.readbyqxmd.com/read/29055111/genetic-based-dissection-of-arsenic-accumulation-in-maize-using-a-genome-wide-association-analysis-method
#1
Zhan Zhao, Huaisheng Zhang, Zhongjun Fu, Hao Chen, Yanan Lin, Pengshuai Yan, Weihua Li, Huiling Xie, Zhanyong Guo, Xuehai Zhang, Jihua Tang
Understanding the mechanism of arsenic (As) accumulation in plants is important in reducing As's toxicity to plants and its potential risks to human health. Here, we performed a genome-wide association study to dissect the genetic basis of the As contents of different maize tissues in Xixian, which was irrigated with As-rich surface water, and Changge using an association population consisting of 230 representative inbred maize lines. Phenotypic data revealed a wide normal distribution and high repeatability for the As contents in maize tissues...
October 21, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29054881/ablation-of-tfr1-in-purkinje-cells-inhibits-mglu1-trafficking-and-impairs-motor-coordination-but-not-autistic-like-behaviors
#2
Jia-Huan Zhou, Xin-Tai Wang, Liang Zhou, Lin Zhou, Fang-Xiao Xu, Li-Da Su, Hao Wang, Fan Jia, Fu-Qiang Xu, Gui-Quan Chen, Chris De Zeeuw, Ying Shen
Group 1 metabotropic glutamate receptors (mGlu1/5) are critical to synapse formation and participate in synaptic long-term potentiation (LTP) and long-term depression (LTD) in the brain. mGlu1/5 signaling alterations have been documented in cognitive impairment, neurodegenerative disorders, and psychiatric diseases, but underlying mechanisms for its modulation are not clear. Here, we report that transferrin receptor 1 (TFR1), a trans-membrane protein of clathrin complex, modulates the trafficking of mGlu1 in cerebellar Purkinje cells (PCs) from male mice...
October 20, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29054167/using-principal-trabecular-orientation-to-differentiate-joint-loading-orientation-in-the-3rd-metacarpal-heads-of-humans-and-chimpanzees
#3
Meir M Barak, Emma Sherratt, Daniel E Lieberman
If Wolff's law is valid, then quantifying the three-dimensional architecture of trabecular bone, specifically 3D principal trabecular orientation (3D-PTO), can reveal joint loading direction among different taxa. This study measured the architecture of trabecular bone in the 3rd metacarpal head of humans and chimpanzees, and then tested their association with expected joint loading direction. We postulate that since chimpanzees, unlike humans, directly load their metacarpal bones during knuckle-walking, trabecular structure in the dorsal aspect of the 3rd metacarpal head will be significantly more organized and robust in chimpanzees...
December 2017: Journal of Human Evolution
https://www.readbyqxmd.com/read/29054036/snava-a-real-time-multi-fpga-multi-model-spiking-neural-network-simulation-architecture
#4
Athul Sripad, Giovanny Sanchez, Mireya Zapata, Vito Pirrone, Taho Dorta, Salvatore Cambria, Albert Marti, Karthikeyan Krishnamourthy, Jordi Madrenas
Spiking Neural Networks (SNN) for Versatile Applications (SNAVA) simulation platform is a scalable and programmable parallel architecture that supports real-time, large-scale, multi-model SNN computation. This parallel architecture is implemented in modern Field-Programmable Gate Arrays (FPGAs) devices to provide high performance execution and flexibility to support large-scale SNN models. Flexibility is defined in terms of programmability, which allows easy synapse and neuron implementation. This has been achieved by using a special-purpose Processing Elements (PEs) for computing SNNs, and analyzing and customizing the instruction set according to the processing needs to achieve maximum performance with minimum resources...
October 5, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29054011/one-pot-fabrication-of-n-doped-graphene-supported-dandelion-like-ptru-nanocrystals-as-efficient-and-robust-electrocatalysts-towards-formic-acid-oxidation
#5
Hui Xu, Bo Yan, Shumin Li, Jin Wang, Caiqin Wang, Jun Guo, Yukou Du
Engineering the architectures of metal nanocatalysts offers a valid approach for the development of electrocatalysts with greatly enhanced performances. Herein, we report the one-pot method to successfully fabricate the N-doped graphene (NG) supported dandelion-like PtRu nanocrystals. Such dandelion-like nanocrystals with different compositions can be readily tuned via the addition of different amounts of RuCl3. By virtue of the large accessible surface active areas, synergistic and electronic effect, as well as the successful introduction of NG, the as-obtained PtRu/NG with optimized compositions display outstandingly high electrocatalytic activity towards formic acid electrooxidation with the mass and specific activities of 1857...
October 13, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29053968/multiscale-3d-genome-rewiring-during-mouse-neural-development
#6
Boyan Bonev, Netta Mendelson Cohen, Quentin Szabo, Lauriane Fritsch, Giorgio L Papadopoulos, Yaniv Lubling, Xiaole Xu, Xiaodan Lv, Jean-Philippe Hugnot, Amos Tanay, Giacomo Cavalli
Chromosome conformation capture technologies have revealed important insights into genome folding. Yet, how spatial genome architecture is related to gene expression and cell fate remains unclear. We comprehensively mapped 3D chromatin organization during mouse neural differentiation in vitro and in vivo, generating the highest-resolution Hi-C maps available to date. We found that transcription is correlated with chromatin insulation and long-range interactions, but dCas9-mediated activation is insufficient for creating TAD boundaries de novo...
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053892/ultra-fast-molecular-rotors-within-porous-organic-cages
#7
Ashlea R Hughes, Nick J Brownbill, Rachel C Lalek, Michael E Briggs, Anna G Slater, Andrew I Cooper, Frederic Blanc
Using variable temperature 2H static NMR spectra and 13C spin-lattice relaxation times (T1), we show that two different porous organic cages with tubular architectures are ultra-fast molecular rotors. The central para-phenylene rings that frame the 'windows' to the cage voids display very rapid rotational rates of the order of 1.2-8 x106 Hz at 230 K with low activation energy barriers in the 12-18 kJ mol-1 range. These cages act as hosts to iodine guest molecules, which dramatically slows down the rotational rates of the phenylene groups (5- 10 x104 Hz at 230 K), demonstrating potential use in applications that require molecular capture and release...
October 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29053581/the-light-node-communication-framework-a-new-way-to-communicate-inside-smart-homes
#8
Valère Plantevin, Abdenour Bouzouane, Sebastien Gaboury
The Internet of things has profoundly changed the way we imagine information science and architecture, and smart homes are an important part of this domain. Created a decade ago, the few existing prototypes use technologies of the day, forcing designers to create centralized and costly architectures that raise some issues concerning reliability, scalability, and ease of access which cannot be tolerated in the context of assistance. In this paper, we briefly introduce a new kind of architecture where the focus is placed on distribution...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053322/strong-coupling-of-microwave-photons-to-antiferromagnetic-fluctuations-in-an-organic-magnet
#9
Matthias Mergenthaler, Junjie Liu, Jennifer J Le Roy, Natalia Ares, Amber L Thompson, Lapo Bogani, Fernando Luis, Stephen J Blundell, Tom Lancaster, Arzhang Ardavan, G Andrew D Briggs, Peter J Leek, Edward A Laird
Coupling between a crystal of di(phenyl)-(2,4,6-trinitrophenyl)iminoazanium radicals and a superconducting microwave resonator is investigated in a circuit quantum electrodynamics (circuit QED) architecture. The crystal exhibits paramagnetic behavior above 4 K, with antiferromagnetic correlations appearing below this temperature, and we demonstrate strong coupling at base temperature. The magnetic resonance acquires a field angle dependence as the crystal is cooled down, indicating anisotropy of the exchange interactions...
October 6, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29053265/step-economical-photoassisted-diversity-oriented-synthesis-sustaining-cascade-photoreactions-in-oxalyl-anilides-to-access-complex-polyheterocyclic-molecular-architectures
#10
Dmitry M Kuznetsov, Andrei G Kutateladze
Atom- and step-economy in photoassisted DOS is achieved with a versatile oxalyl linker offering rapid access to complex alkaloid mimics in very few experimentally simple steps: (i) it allows for fast tethering of the photoactive core to the unsaturated pendants, especially im-portant in the case of (hetero)aromatic amines - essentially a one pot reaction with no isolation of intermediates; (ii) the α-dicarbonyl tether acts as a chromophore enhancer, extending the conjugation chain and facilitating the 'harvest' of the lower energy photons for the primary and secondary photoreactions, (iii) it enhances the quantum yield of intersystem crossing (ISC), i...
October 20, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29053246/driving-chemical-reactions-in-plasmonic-nanogaps-with-electrohydrodynamic-flow
#11
William John Thrift, Cuong Quoc Nguyen, Mahsa Darvishzadeh-Varcheie, Siavash Zare, Nicholas Sharac, Robert Noboru Sanderson, Torin J Dupper, Allon I Hochbaum, Filippo Capolino, Mohammad Javad Abdolhosseini Qomi, Regina Ragan
Nanoparticles from colloidal solution - with controlled composition, size, and shape - serve as excellent building blocks for plasmonic devices and metasurfaces. However, understanding hierarchical driving forces affecting geometry of oligomers and interparticle gap spacings is still needed to fabricate high density architectures over large areas. Here, electrohydrodynamic (EHD) flow is used as a long-range driving force to enable carbodiimide crosslinking between nanospheres and produces oligomers exhibiting sub-nanometer gap spacing over mm(2) areas...
October 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29053212/mimicking-the-rose-petal-and-lotus-leaf-effects-on-alumina-by-surface-functionalization-and-metal-ion-coordination
#12
Rahul Dev Mukhopadhyay, Balaraman Vedhanarayanan, Ayyappanpillai Ajayaghosh
Functional difference of superhydrophobic surfaces such as lotus leaf and rose petals are due to the subtle architectural features created by Nature. Mimicry of these surfaces with synthetic molecules continues to be fascinating as well as challenging. Herein, we demonstrate how the wetting property of inherently hydrophilic alumina surface can be modified with two distinct superhydrophobic behaviors. Functionalization of alumina with an organic ligand resulted in a rose petal-like surface (water pinning) with a contact angle of 145° and a high contact angle hysteresis (± 69°)...
October 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29052939/qtl-mapping-and-analysis-of-heritable-variation-in-affiliative-social-behavior-and-related-traits
#13
Allison T Knoll, Kevin Jiang, Pat Levitt
Humans exhibit broad heterogeneity in affiliative social behavior. Twin and family studies demonstrate that individual differences in core dimensions of social behavior are heritable, yet there are knowledge gaps in understanding the underlying genetic and neurobiological mechanisms. Animal genetic reference panels (GRPs) provide a tractable strategy for examining the behavioral and genetic architecture of complex traits. Here, using males from 50 mouse strains from the BXD GRP, four domains of affiliative social behavior-social approach, social recognition, direct social interaction (partner sniffing), and vocal communication-were examined in two widely used behavioral tasks-the 3-chamber and direct social interaction tasks...
October 20, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29052907/organic-diode-rectifiers-based-on-a-high-performance-conjugated-polymer-for-a-near-field-energy-harvesting-circuit
#14
Stuart G Higgins, Tiziano Agostinelli, Steve Markham, Robert Whiteman, Henning Sirringhaus
Organic diodes manufactured on a plastic substrate capable of rectifying a high-frequency radio-frequency identification signal (13.56 MHz), with sufficient power to operate an interactive smart tag, are reported. A high-performance conjugated semiconductor (an indacenodithiophene-benzothiadiazole copolymer) is combined with a carefully optimized architecture to satisfy the electrical requirements for an organic-semiconductor-based logic chip.
October 20, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29052784/exercise-and-bone-health-across-the-lifespan
#15
Lívia Santos, Kirsty Jayne Elliott-Sale, Craig Sale
With ageing, bone tissue undergoes significant compositional, architectural and metabolic alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone disorder, which is characterised by progressive bone weakening and an increased risk of fragility fractures. Although this metabolic disease is conventionally associated with ageing and menopause, the predisposing factors are thought to be established during childhood and adolescence. In light of this, exercise interventions implemented during maturation are likely to be highly beneficial as part of a long-term strategy to maximise peak bone mass and hence delay the onset of age- or menopause-related osteoporosis...
October 20, 2017: Biogerontology
https://www.readbyqxmd.com/read/29052760/impact-of-plasmid-architecture-on-stability-and-yegfp3-reporter-gene-expression-in-a-set-of-isomeric-multicopy-vectors-in-yeast
#16
Ruben Hohnholz, Kim Julia Pohlmann, Tilman Achstetter
Multicopy episomal plasmids in yeast, used whenever elevated levels of foreign or homologous gene expression are necessary, are known to be less stable compared to the endogenous 2-μm plasmid they are based on, at least without selective pressure. Considering that rich medium favors growth rate and, simultaneously, is less expensive than selective medium, enhancing stability in non-selective medium is extremely desirable. In this study, we changed the architecture of a multicopy model expression plasmid, creating six isoforms (same size, same DNA content but different positions and orientations of the expression block) and studied mitotic stability, copy number, as well as reporter yEGFP3 expression between isoforms...
October 20, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29052676/growth-and-nanomechanical-characterization-of-nanoscale-3d-architectures-grown-via-focused-electron-beam-induced-deposition
#17
Brett B Lewis, Brittnee A Mound, Bernadeta Srijanto, Jason D Fowlkes, George M Pharr, Philip D Rack
Nanomechanical measurements of platinum-carbon 3D nanoscale architectures grown via focused electron beam induced deposition (FEBID) were performed using a nanoindentation system in a scanning electron microscope (SEM) for simultaneous in situ imaging. Compression tests were used to estimate the modulus of the platinum-carbon deposits to be in the range of 8.6-10.5 GPa. Cantilever arm bend tests resulted in a modulus estimation of 15.6 GPa. Atomic layer deposition was used to conformally coat FEBID structures with a thin film of Al2O3, which strengthened the structures and increased the measured modulus...
October 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/29052596/t-6-11-renal-cell-carcinoma-a-study-of-seven-cases-including-two-with-aggressive-behavior-and-utility-of-cd68-pg-m1-in-the-differential-diagnosis-with-pure-epithelioid-pecoma-epithelioid-angiomyolipoma
#18
Anna Caliò, Matteo Brunelli, Diego Segala, Serena Pedron, Regina Tardanico, Andrea Remo, Stefano Gobbo, Emanuela Meneghelli, Claudio Doglioni, Ondrej Hes, Claudia Zampini, Pedram Argani, Guido Martignoni
Renal cell carcinomas with t(6;11) chromosome translocation involving the TFEB gene are indolent neoplasms which often occur in young patients. In this study, we report seven cases of renal cell carcinoma with TFEB rearrangement, two of whom had histologically proven metastasis. Patients (4F, 3M) ranged in age from 19 to 55 years (mean 37). One patient developed paratracheal and pleural metastases 24 months after surgery and died of disease after 46 months; another one recurred with neoplastic nodules in the perinephric fat and pelvic soft tissue...
October 20, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29052528/different-genetic-architectures-underlie-crop-responses-to-the-same-pathogen-the-helianthus-annuus-phoma-macdonaldii-interaction-case-for-black-stem-disease-and-premature-ripening
#19
Amandine Bordat, Gwenaëlle Marchand, Nicolas B Langlade, Nicolas Pouilly, Stéphane Muños, Grégory Dechamp-Guillaume, Patrick Vincourt, Emmanuelle Bret-Mestries
BACKGROUND: Phoma macdonaldii has been reported as the causal agent of black stem disease (BS) and premature ripening (PR) on sunflower. PR is considered as the most widespread and detrimental disease on sunflower in France. While genetic variability and QTL mapping for partial resistance of sunflower to stem, collar and roots attacks have been reported on plantlets in controlled conditions, this work aims to describe the genetic variability in a subset of a sunflower lines, and for the first time to map QTL involved in PR resistance evaluated in field conditions using controlled inoculation...
October 19, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29052506/the-proposed-new-species-cacao-red-vein-virus-and-three-previously-recognized-badnavirus-species-are-associated-with-cacao-swollen-shoot-disease
#20
Nomatter Chingandu, Koffie Kouakou, Romain Aka, George Ameyaw, Osman A Gutierrez, Hans-Werner Herrmann, Judith K Brown
BACKGROUND: Cacao swollen shoot virus (CSSV), Cacao swollen shoot CD virus (CSSCDV), and Cacao swollen shoot Togo A virus (CSSTAV) cause cacao swollen shoot disease (CSSD) in West Africa. During 2000-2003, leaf and shoot-swelling symptoms and rapid tree death were observed in cacao in Cote d'Ivoire and Ghana. Molecular tests showed positive infection in only ~50-60% of symptomatic trees, suggesting the possible emergence of an unknown badnavirus. METHODS: The DNA virome was determined from symptomatic cacao samples using Illumina-Hi Seq, and sequence accuracy was verified by Sanger sequencing...
October 19, 2017: Virology Journal
keyword
keyword
14228
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"