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https://www.readbyqxmd.com/read/28732269/gyral-net-a-new-representation-of-cortical-folding-organization
#1
Hanbo Chen, Yujie Li, Fangfei Ge, Gang Li, Dinggang Shen, Tianming Liu
One distinct feature of the cerebral cortex is its convex (gyri) and concave (sulci) folding patterns. Due to the remarkable complexity and variability of gyral/sulcal shapes, it has been challenging to quantitatively model their organization patterns. Inspired by the observation that the lines of gyral crests can form a connected graph on each brain hemisphere, we propose a new representation of cortical gyri/sulci organization pattern - gyral net, which models cortical architecture from a graph perspective, starting with nodes and edges obtained from the reconstructed cortical surfaces...
July 15, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/28732238/community-action-for-health-in-india-s-national-rural-health-mission-one-policy-many-paths
#2
Rakhal Gaitonde, Miguel San Sebastian, V R Muraleedharan, Anna-Karin Hurtig
Community participation as a strategy for health system strengthening and accountability is an almost ubiquitous policy prescription. In 2005, with the election of a new Government in India, the National Rural Health Mission was launched. This was aimed at 'architectural correction' of the health care system, and enshrined 'communitization' as one of its pillars. The mission also provided unique policy spaces and opportunity structures that enabled civil society groups to attempt to bring on to the policy agenda as well as implement a more collective action and social justice based approach to community based accountability...
July 1, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28732180/the-role-of-noncoding-genetic-variation-in-isolated-orofacial-clefts
#3
F Thieme, K U Ludwig
In the past decade, medical genetic research has generated multiple discoveries, many of which were obtained via genome-wide association studies (GWASs). A major GWAS finding is that the majority of risk variants for complex traits map to noncoding regions. This has resulted in a paradigm shift in terms of the interpretation of human genomic sequence variation, with more attention now being paid to what was previously termed "junk DNA." Translation of genetic findings into biologically meaningful results requires 1) large-scale and cell-specific efforts to annotate non-protein-coding regions and 2) the integration of comprehensive genomic data sets...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28732161/an-elegant-ph-responsive-nanovehicle-for-drug-delivery-based-on-triazine-dendrimer-modified-magnetic-nanoparticles
#4
Amir Landarani-Isfahani, Majid Moghadam, Shima Mohammadi, Maryam Royvaran, Naimeh Moshtael-Arani, Saghar Rezaei, Shahram Tangestaninejad, Valiollah Mirkhani, Iraj Mohammadpoor-Baltork
Owing to properties of magnetic nanoparticles and elegant three-dimensional macromolecule architectural features, dendrimeric structures have been investigated as nanoscale drug delivery systems. In this paper, a novel magnetic nanocarrier, generation two (G2) triazine dendrimer modified Fe3O4@SiO2 magnetic nanoparticles (MNP-G2), was designed, fabricated and characterized by Fourier transform infrared (FT-IR), thermal gravimetric analysis (TGA), vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM) and dynamic light scattering (DLS)...
July 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28732157/large-scale-statistics-for-threshold-optimization-of-optically-pumped-nanowire-lasers
#5
Juan Arturo Alanis, Dhruv Saxena, Sudha Mokkapati, Nian Jiang, Kun Peng, Xiaoyan Tang, Lan Fu, Hark Hoe Tan, Chennupati Jagadish, Patrick Parkinson
Single nanowire lasers based on bottom-up III-V materials have been shown to exhibit room-temperature near-infrared lasing, making them highly promising for use as nanoscale, silicon-integrable and coherent light sources. While lasing behavior is reproducible, small variations in growth conditions across a substrate arising from the use of bottom-up growth techniques can introduce inter-wire disorder, either through geometric or material inhomogeneity. Nanolasers critically depend on both high material quality and tight dimensional tolerances, and as such, lasing threshold is both sensitive to, and a sensitive probe of such inhomogeneity...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28731825/convergent-phenotypic-evolution-despite-contrasting-demographic-histories-in-the-fauna-of-white-sands
#6
Erica Bree Rosenblum, Christine E Parent, Eveline T Diepeveen, Clay Noss, Ke Bi
When are evolutionary outcomes predictable? Cases of convergent evolution can shed light on when, why, and how different species exhibit shared evolutionary trajectories. In particular, studying diverse species in a common environment can illuminate how different factors facilitate or constrain adaptive evolution. Here we integrate studies of pattern and process in the fauna at White Sands (New Mexico) to understand the determinants of convergent evolution. Numerous animal species at White Sands exhibit phenotypic convergence in response to a novel-and shared-selective environment: geologically young gypsum dunes...
August 2017: American Naturalist
https://www.readbyqxmd.com/read/28731700/nanomanipulation-of-individual-dna-molecules-covered-by-single-layered-reduced-graphene-oxide-sheets-on-a-solid-substrate
#7
Ying Wang, Yue Shen, Bin Li, Shuo Wang, Jinjin Zhang, Yi Zhang, Jun Hu
Nanomanipulation of single DNA molecules has great potential in fundamental genetic research and clinical analysis, and is a good model system for studying the interfacial effects on physiochemical processes, which occur when manipulating the linear DNA molecules with an atomic force microscope (AFM) tip. Here, we demonstrate that AFM nanomanipulation can be carried out on DNA molecules covered by a single-layered reduced graphene oxide sheet. Nanomanipulation, which includes cutting, pushing, and sweeping operations, specific to the covered DNA molecules can be achieved in a well-controlled manner using AFM in the PeakForce Quantitative Nano-Mechanics mode...
July 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28731681/the-first-n-borylated-emitters-displaying-highly-efficient-thermally-activated-delayed-fluorescence-and-high-performance-oleds
#8
Yi-Jyun Lien, Tzu-Chieh Lin, Chun-Chieh Yang, Yu-Cheng Chiang, Chih-Hao Chang, Shih-Hung Liu, Yi-Ting Chen, Gene-Hsiang Lee, Pi-Tai Chou, Chin-Wei Lu, Yun Chi
Despite the fast boom of thermally activated delayed fluorescence (TADF) emitters bearing borane-based acceptor, so far, none of TADF emitters with a direct B-N linkage between N-donor and boryl acceptor has been reported. The latter should simplify molecular architecture and hence facilitate the synthetic design and versatility. We report here the preparation and characterization of a new series of N-borylated compounds with functional acridine donor unit; namely: ACBM, PACBM and SACBM. Spectroscopic studies were performed to explore their photophysical properties that exhibited prominent solvatochromism and thermally activated delayed fluorescence...
July 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28731567/integration-of-white-matter-network-is-associated-with-interindividual-differences-in-psychologically-mediated-placebo-response-in-migraine-patients
#9
Jixin Liu, Shaohui Ma, Junya Mu, Tao Chen, Qing Xu, Wanghuan Dun, Jie Tian, Ming Zhang
Individual differences of brain changes of neural communication and integration in the modular architecture of the human brain network exist for the repeated migraine attack and physical or psychological stressors. However, whether the interindividual variability in the migraine brain connectome predicts placebo response to placebo treatment is still unclear. Using DTI and graph theory approaches, we systematically investigated the topological organization of white matter networks in 71 patients with migraine without aura (MO) and 50 matched healthy controls at three levels: global network measure, nodal efficiency, and nodal intramodule/intermodule efficiency...
July 21, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28731353/altering-dna-programmable-colloidal-crystallization-paths-by-modulating-particle-repulsion
#10
Mary X Wang, Jeffrey D Brodin, Jaime A Millan, Soyoung E Seo, Martin Girard, Monica Olvera de la Cruz, Byeongdu Lee, Chad A Mirkin
Colloidal crystal engineering with DNA can be used to realize precise control over nanoparticle (NP) arrangement. Here, we investigate a case of DNA-based assembly where the properties of DNA as a polyelectrolyte brush are employed to alter a hybridization-driven NP crystallization pathway. Using the coassembly of DNA-conjugated proteins and spherical gold nanoparticles (AuNPs) as a model system, we explore how steric repulsion between noncomplementary, neighboring NPs due to overlapping DNA shells can influence their ligand-directed behavior...
July 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/28731264/high-yield-synthesis-of-crystal-phase-heterostructured-4h-fcc-au-pd-core-shell-nanorods-for-electrocatalytic-ethanol-oxidation
#11
Ye Chen, Zhanxi Fan, Zhimin Luo, Xiaozhi Liu, Zhuangchai Lai, Bing Li, Yun Zong, Lin Gu, Hua Zhang
Noble-metal nanomaterials are attracting increasing research interest due to their promising applications in electrochemical catalysis, for example. Although great efforts have been devoted to the size-, shape-, and architecture-controlled synthesis of noble-metal nanomaterials, their crystal-phase-controlled synthesis is still in its infancy. Here, for the first time, this study reports high-yield synthesis of Au nanorods (NRs) with alternating 4H/face-centered cubic (fcc) crystal-phase heterostructures via a one-pot wet-chemical method...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28731030/cryo-em-structure-and-biochemical-analysis-reveal-the-basis-of-the-functional-difference-between-human-pi3kc3-c1-and-c2
#12
Meisheng Ma, Jun-Jie Liu, Yan Li, Yuwei Huang, Na Ta, Yang Chen, Hua Fu, Ming-Da Ye, Yuehe Ding, Weijiao Huang, Jia Wang, Meng-Qiu Dong, Li Yu, Hong-Wei Wang
Phosphatidylinositol 3-phosphate (PI3P) plays essential roles in vesicular trafficking, organelle biogenesis and autophagy. Two class III phosphatidylinositol 3-kinase (PI3KC3) complexes have been identified in mammals, the ATG14L complex (PI3KC3-C1) and the UVRAG complex (PI3KC3-C2). PI3KC3-C1 is crucial for autophagosome biogenesis, and PI3KC3-C2 is involved in various membrane trafficking events. Here we report the cryo-EM structures of human PI3KC3-C1 and PI3KC3-C2 at sub-nanometer resolution. The two structures share a common L-shaped overall architecture with distinct features...
July 21, 2017: Cell Research
https://www.readbyqxmd.com/read/28730682/structure-and-development-of-the-subesophageal-zone-of-the-drosophila-brain-i-segmental-architecture-compartmentalization-and-lineage-anatomy
#13
Volker Hartenstein, Jaison J Omoto, Kathy T Ngo, Darren Wong, Philipp A Kuert, Heinrich Reichert, Jennifer K Lovick, Amelia Younossi-Hartenstein
The subesophageal zone (SEZ) of the Drosophila brain houses the circuitry underlying feeding behavior and is involved in many other aspects of sensory processing and locomotor control. Formed by the merging of four neuromeres, the internal architecture of the SEZ can be best understood by identifying segmentally reiterated landmarks emerging in the embryo and larva, and following the gradual changes by which these landmarks become integrated into the mature SEZ during metamorphosis. In previous works, the system of longitudinal fibers (connectives) and transverse axons (commissures) has been utilized as a scaffold that provides internal landmarks for the neuromeres of the larval ventral nerve cord...
July 21, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28730675/hierarchical-hybrids-integrated-by-dual-polypyrrole-based-porous-carbons-for-enhanced-capacitive-performance
#14
Zhiwei Li, Nannan Chen, Hongyu Mi, Junhong Ma, Yahong Xie, Jieshan Qiu
Architectural design of nitrogenous polymer-based carbons represents a facile and efficient strategy in performance improvement because of their morphological diversity, tailorability, and N-containing structure. In this research, polypyrrole-derived porous carbons (A-PCS and A-PCT) in zero- and one-dimensional (0D and 1D) forms are first integrated to nitrogen-doped hierarchically porous A-PCS/PCT hybrids through an easy multi-step method. This integration, along with chemical activation, prevents serious agglomeration of carbon particles or tubes and creates a through-connected porous network structure, leading to the improved textural properties (high surface area of 1684 m2 g-1, high pore volume of 1...
July 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28730671/many-faces-of-rationality-implications-of-the-great-rationality-debate-for-clinical-decision-making
#15
Benjamin Djulbegovic, Shira Elqayam
Given that more than 30% of healthcare costs are wasted on inappropriate care, suboptimal care is increasingly connected to the quality of medical decisions. It has been argued that personal decisions are the leading cause of death, and 80% of healthcare expenditures result from physicians' decisions. Therefore, improving healthcare necessitates improving medical decisions, ie, making decisions (more) rational. Drawing on writings from The Great Rationality Debate from the fields of philosophy, economics, and psychology, we identify core ingredients of rationality commonly encountered across various theoretical models...
July 20, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28730563/functional-connectivity-and-cognitive-impairment-in-migraine-with-and-without-aura
#16
Viviana Lo Buono, Lilla Bonanno, Francesco Corallo, Laura Rosa Pisani, Riccardo Lo Presti, Rosario Grugno, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino
BACKGROUND: Several fMRI studies in migraine assessed resting state functional connectivity in different networks suggesting that this neurological condition was associated with brain functional alteration. The aim of present study was to explore the association between cognitive functions and cerebral functional connectivity, in default mode network, in migraine patients without and with aura, during interictal episodic attack. METHODS: Twenty-eight migraine patients (14 without and 14 with aura) and 14 matched normal controls, were consecutively recruited...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28730451/using-planar-phi29-prna-three-way-junction-to-control-size-and-shape-of-rna-nanoparticles-for-biodistribution-profiling-in-mice
#17
Farzin Haque, Congcong Xu, Daniel L Jasinski, Hui Li, Peixuan Guo
RNA is rapidly emerging as a versatile building block for nanoparticle assembly due to its simplicity in base pairing, while exhibiting diversity in function such as enzymatic activity similar to some proteins. Recent advances in RNA nanotechnology have generated significant interests in applying RNA nanoparticles for various applications in nanotechnology and nanomedicine. In particular, assessing the effect of size and shape on cell entry and intracellular trafficking as well as in vivo biodistribution of nanoparticles is challenging due to the lack of nanoparticles rich in structure while varying in size and shape...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730437/design-and-crystallography-of-self-assembling-rna-nanostructures
#18
Mark A Boerneke, Thomas Hermann
Biological RNA architectures are composed of autonomously folding modules which can be tailored as building blocks for the construction of RNA nanostructures. Designed base pair interactions allow complex nano-objects to self-assemble from simple RNA motifs. X-ray crystallography plays an important role in both the design and analysis of such RNA nanostructures. Here, we describe methods for the design and X-ray crystallographic structure analysis of an RNA square and two different triangles, which self-assemble from short oligonucleotides and serve as a platform for building functional nano-sized nucleic acid architectures...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28730262/crypt-hyperplastic-enteropathy-in-distal-duodenum-in-helicobacter-pylori-infection-report-of-two-cases-without-evidence-of-celiac-disease
#19
Mariana Jinga, Daniel Vasile Balaban, Ileana Peride, Andrei Niculae, Irina Monica DuŢescu, Florina Vasilescu, Markku Mäki, Alina Mihaela Popp
OBJECTIVES: Patients with Helicobacter pylori (HP) infection have been reported to have in addition to duodenitis architectural changes of the duodenal bulb mucosa including villous atrophy and crypt hyperplasia. We here for the first time present two cases of HP-infected adult patients with a crypt hyperplastic enteropathy also in the distal duodenum mimicking celiac disease (CD). METHODS: We evaluated separately the morphology of the anatomical bulb and distal duodenal mucosa using validated quantitative morphometric tools, i...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28730205/dithieno-3-2-b-2-3-d-pyrrole-benzo-c-1-2-5-thiadiazole-conjugate-small-molecule-donors-effect-of-fluorine-content-on-their-photovoltaic-properties
#20
Manohar Reddy Busireddy, Narendra Reddy Chereddy, Balaiah Shanigaram, Bhanuprakash Kotamarthi, Subhayan Biswas, Ganesh Datt Sharma, Jayathirtha Rao Vaidya
Two new small molecule donors, namely ICT4 and ICT6 with D1-A-D2-A-D1 architecture having 2,4-bis(2-ethylhexyl)-4H-dithieno[3,2-b:2',3'-d]pyrrole (EHDTP, D1) and 4,8-bis((2-ethylhexyl)oxy)benzo[1,2-b:4,5-b']dithiophene (OBDT, D2) as the terminal and central donor, and benzo[c][1,2,5]thiadiazole (BT for ICT4) and 5,6-difluorobenzo[c][1,2,5]thiadiazole (F2BT for ICT6) as the acceptor (A) moieties, are synthesized and their optical, electronic and photovoltaic properties are investigated. Both ICT4 and ICT6 have considerable solubility in various solvents and possess efficient light absorption ability [ε (×10(5) mol(-1) cm(-1)) is 0...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
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