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serpiginous choroiditis

Elisabetta Miserocchi, Luigi Berchicci, Lorenzo Iuliano, Giulio Modorati, Francesco Bandello
BACKGROUND/AIMS: To assess the efficacy and safety of dexamethasone (DEX) intravitreal implant in patients with active serpiginous choroiditis (SC) already receiving maximal tolerated systemic immunosuppressive therapy. METHODS: In this retrospective longitudinal study we evaluated patients receiving 0.7 mg DEX intravitreal implant for active SC despite maximal systemic immunosuppression. Medical history was reviewed over a period of 18 months for each patient...
June 2, 2016: British Journal of Ophthalmology
Alessandro Invernizzi, Aniruddha Agarwal, Mariano Cozzi, Francesco Viola, Quan Dong Nguyen, Giovanni Staurenghi
PURPOSE: To detect choriocapillaris changes by enhanced depth imaging optical coherence tomography (EDI-OCT) in areas of choriocapillaris hypoperfusion visualized on indocyanine green angiography. METHODS: Combined indocyanine green angiography and EDI-OCT from patients diagnosed with inflammatory choriocapillaris hypoperfusion were retrospectively analyzed. The EDI-OCTs were compared with indocyanine green angiography to detect choriocapillaris changes suggestive of choriocapillaris hypoperfusion in both active stage (AS) and inactive stage of the disease...
October 2016: Retina
Pieter Lambrecht, Marnix Claeys, Ilse De Schryver
PURPOSE: Presentation of a case report of a unilateral ampiginous choroiditis. METHODS: This is an observational case report. RESULTS: A 70-year-old woman was referred to us with unilateral scattered chorioretinal lesions. The multifocal pattern of the lesions and the angiographic features led to the diagnosis of ampiginous choroiditis. CONCLUSION: Ampiginous choroiditis is a primary inflammatory choriocapillaropathy with characteristics of both acute posterior multifocal placoid pigment epitheliopathy and serpiginous choroiditis...
September 2015: Case Reports in Ophthalmology
Ali Osman Saatci, Ziya Ayhan, Ceren Engin Durmaz, Omer Takes
Intravitreal anti-vascular endothelial growth factor (VEGF) agents seem to be effective in choroidal neovascular membranes (CNV) in association with various entities of posterior uveitis. We herein report a 46-year-old woman who was treated with a simultaneous single intravitreal dexamethasone implant and ranibizumab administration for the treatment of unilateral extrafoveal CNV associated with an active serpiginous choroiditis. Simultaneously with the intravitreal therapy, oral mycophenolic acid (2 × 720 mg) was started, and oral cyclosporine (3 × 100 mg) was then added 2 months later...
September 2015: Case Reports in Ophthalmology
Hah Yan Yee, Pearse A Keane, Su Ling Ho, Rupesh Agrawal
Choroidal neovascularization secondary to tuberculous serpiginous-like choroiditis (Tb-SLC) is uncommon and requires further invasive imaging, such as fluorescein and indocyanine green angiography. We evaluate the optical coherence tomography angiography (OCTA) findings in a patient with a Tb-SLC and present the use of this investigation as a non-invasive diagnostic and follow-up clinical tool in this disease.
January 30, 2016: Ocular Immunology and Inflammation
Rupesh Agrawal, Bhaskar Gupta, Julio J González-López, João Cardoso, Ioanna Triantafullopoulou, Robert Grant, Peter K F Addison, Mark Westcott, Carlos E Pavesio
OBJECTIVE: To describe the clinical spectrum and outcome of patients with presumed tubercular uveitis and choroidal involvement. METHODS: A retrospective case series nested in a cohort study was enrolled at a tertiary referral eye care center in the UK. Failure was defined as recurrence of lesion within 6 months of completion of antitubercular therapy (ATT) or corticosteroid therapy. RESULTS: Seventy-seven patients with presumed ocular tuberculosis and choroidal involvement were included in the study...
January 25, 2016: Ocular Immunology and Inflammation
Patrik Schatz, Angelika Skarin, Alejandro J Lavaque, Luiz E Lima, Jose Fernando Arevalo
No abstract text is available yet for this article.
January 18, 2016: Acta Ophthalmologica
Sachin B Shetty, Jyotirmay Biswas, Sowmiya Murali
BACKGROUND: The term multifocal serpiginoid choroiditis (MSC) has been proposed for the infective variant of serpiginous choroiditis (SC) to distinguish it from typical SC believed to be autoimmune related. The role of Mycobacterium tuberculosis (MTb) in MSC has been studied by conventional polymerase chain reaction (PCR). However, the use of real-time PCR (RT-PCR) and nested PCR (N-PCR) in MSC has not been reported. This paper aims to highlight the usefulness of PCR in identifying MTb as a causative agent for MSC leading to its correct treatment with anti-tubercular therapy (ATT)...
December 2014: Journal of Ophthalmic Inflammation and Infection
Meriem Abdellaoui, Hicham Tahri
No abstract text is available yet for this article.
2015: Pan African Medical Journal
Hakima Elouarradi, Samira Tachfouti, Lalla Ouafae Cherkaoui, Othmane Charhi, Uchama Daoudi, Saloua Khalil, Nouha Zerkaoui, Amal Alouane, Kamal Naciri, Rajae Daoudi
No abstract text is available yet for this article.
2015: Pan African Medical Journal
Kalpana Babu, Soumya S Bhat, Mariamma Philips, D K Subbakrishna
AIM: To review the results of QuantiFERON TB gold (QFT-G) in our patient population of presumed ocular tuberculosis and the effect of antitubercular therapy (ATT) on the QFT-G result. MATERIALS AND METHODS: Retrospective review of 82 cases of presumed ocular tuberculosis with a successful response to ATT and 6 months follow-up post-ATT. Appropriate statistical analysis was done for associations between QFT-G and independent variables. Pre-ATT QFT-G values were also compared to the post-ATT value...
October 2016: Ocular Immunology and Inflammation
Pradeep Venkatesh, Varun Gogia, Shikha Gupta, Akshay Tayade, Neha Shilpy, Bhavin M Shah, Randeep Guleria
PURPOSE: To evaluate safety and efficacy of intravenous pulse cyclophosphamide (CyP) in acute macular serpiginous choroiditis (SC). METHODS: Patients with acute macular SC with lesions threatening and/or involving fovea were enrolled. All patients received CyP (1 g/m2) for 3 days followed by high-dose oral steroids (1.5 mg/kg) tapered over 6 months and monitored for visual acuity, response to treatment and systemic side effects. RESULTS: Eight patients (seven unilateral and one bilateral) with median age of 27 years (range: 13-40 years) were recruited...
April 2015: Indian Journal of Ophthalmology
Panagiotis Malamos, Panos Masaoutis, Ilias Georgalas, Stelios Maselos, Konstantinos Andrianopoulos, Chryssanthi Koutsandrea, Nikos N Markomichelakis
BACKGROUND: To evaluate the correlation of fundus autofluorescence (FAF) with indocyanine green angiography (ICGA) in patients with various posterior uveitis disorders. METHODS: Interventional case series including 23 eyes of 15 patients with diagnosis of a specific type of retinochoroiditis, such as acute posterior multifocal placoid pigment epitheliopathy (APMPPE), serpiginous-like choroiditis, multifocal choroiditis (MFC), Harada disease, and syphilitic retinochoroiditis...
2015: BioMed Research International
Vishali Gupta, Samir S Shoughy, Sarakshi Mahajan, Moncef Khairallah, James T Rosenbaum, Andre Curi, Khalid F Tabbara
PURPOSE: Ocular tuberculosis is an extrapulmonary tuberculous condition and has variable manifestations. The purpose of this review is to describe the clinical manifestations of ocular tuberculosis affecting the anterior and posterior segments of the eye in both immunocompetent and immunocompromised patients. METHODS: Review of literature using Pubmed database. RESULTS: Mycobacterium tuberculosis may lead to formation of conjunctival granuloma, nodular scleritis, and interstitial keratitis...
February 2015: Ocular Immunology and Inflammation
Jane M Wells, Justine R Smith
No abstract text is available yet for this article.
September 2014: Clinical & Experimental Ophthalmology
Cecilia S Lee, Aaron Y Lee, Farzin Forooghian, Chris S Bergstrom, Jiong Yan, Steven Yeh
PURPOSE: To describe the fundus autofluorescence (FAF) features of the inflammatory maculopathies and develop a quantification method for FAF analysis. METHODS: This is a retrospective, consecutive case series of patients with inflammatory maculopathies from two tertiary centers. The clinical findings, demographics, and FAF imaging characteristics were reviewed. Foveal autofluorescence (AF) was analyzed. Median and standard deviation (SD) of foveal AF intensity were measured...
2014: Clinical Ophthalmology
Emmett T Cunningham, Amod Gupta, Manfred Zierhut
No abstract text is available yet for this article.
October 2014: Ocular Immunology and Inflammation
Aditi Gupta, Jyotirmay Biswas
No abstract text is available yet for this article.
May 2014: Oman Journal of Ophthalmology
Enzo D'Ambrosio, Paolo Tortorella, Ludovico Iannetti
Inflammatory choroidal neovascularization is a severe but uncommon complication of uveitis, more frequent in posterior uveitis such as punctate inner choroidopathy, multifocal choroiditis, serpiginous choroiditis, and Vogt-Koyanagi-Harada syndrome. Its pathogenesis is supposed to be similar to the wet age related macular degeneration: hypoxia, release of vascular endothelial growth factor, stromal cell derived factor 1-alpha, and other mediators seem to be involved in the uveitis-related choroidal neovascularization...
2014: Journal of Ophthalmology
H Elouarradi, O Charhi, S Tachfouti, Z Hafidi, S Khalil, C Daoudi, O Belhaj, A Alouane, N Zerkaoui, H Handor, O Cherkaoui, A Amazouzi, R Daoudi
No abstract text is available yet for this article.
September 2014: Journal Français D'ophtalmologie
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