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H Zhang, C Xu, Y Liu, W Yuan
Objective: To investigate the function and mechanism of miR-563 in regulating the ossification of posterior longitudinal ligament (OPLL) cells. Methods: Posterior longitudinal ligament cells were isolated and cultured from both OPLL patients (n=6) and non-ossified ligament patients (PLL, n=4) who underwent spine surgery from March to June 2015 in First Department of Spinal Surgery, Changzheng Hospital Affiliated to Second Military Medical University. The expression levels of miR-563 in OPLL and PLL groups were analyzed using real-time PCR...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
M Huang, Q Cai, H H Li, D Lou
Objective: To investigate the impacts of paraquat on microRNA profiles in apoptosis of human neural progenitor cells (hNPCs) and to explore miRNA targets and biological functions. Methods: We used hNPCs as a popular in vitro cell model system for characterizing the neurotoxicity. Cell apoptosis was detected by Annexin V-APC/7-AAD after 24 h treatment with different concentrations of PQ (0, 5, 10, 20, 40, 80 μmol/L). Microarray profiling expression of PQ treated cell line and their corresponding control was determined and differentially expression miRNAs were confirmed by quantitatively real-time PCR...
January 20, 2017: Chinese Journal of Industrial Hygiene and Occupational Diseases
Zhongqiu Sun, Di Wu, Yunfeng Lv
The optical scattering property of a target is the essential signal for passive remote sensing. In this study, we performed the photopolarimetric measurements of a manmade target in the wavelength range of 400-1000 nm over the hemispherical directions using the Northeast Normal University Laboratory Goniospectrometer System (NENULGS). We discussed the influence of the absorption of a polarizer on the measured Stokes parameters, and used the BRF (bidirectional reflectance factor) and BPRF (bidirectional polarized reflectance factor) to characterize the scattering property of our sample at selected wavelengths...
February 20, 2017: Optics Express
Aya Nozaki, Masaya Mitobe, Fumio Okuyama, Yuji Sakamoto
Electro-holography can display images without inducing fatigue and three-dimensional (3D) sickness, i.e., visual discomfort due to viewing a stereoscopic display. Thus, this technology is expected to be applied to 3D media. However, there are no studies that have shown the agreement between the dynamic responses of accommodation and vergence to the reconstructed images of electro-holography and those to the real targets. This paper describes the measurement results of these responses using a developed system that can simultaneously measure the dynamic responses of accommodation and vergence...
February 20, 2017: Optics Express
Jin Li, Zilong Liu, Fengdeng Liu
Space smart optical orbiting payloads integrated with attitude and position (SSPIAP) are emerging as an essential tool that is extensively used in microsatellites. The on-orbit imaging link of SSPIAPs includes atmospheric disturbances, defocusing, and relative motion, and other noises, thereby resulting in low modulation transfer function (MTF) and poor image quality. The introduction of MTF compensations has pushed the limits of optical imaging, enabling high-resolution on-orbit dynamic imaging. However, the external targets for compensating MTF are limited by space and time because the availability and access to external targets are infrequently easy when a remote sensor is working on-orbit...
February 20, 2017: Optics Express
Michelle Cua, Edward Haojiang Zhou, Changhuei Yang
Optical microscopy in complex, inhomogeneous media is challenging due to the presence of multiply scattered light that limits the depths at which diffraction-limited resolution can be achieved. One way to circumvent the degradation in resolution is to use speckle- correlation-based imaging (SCI) techniques, which permit imaging of objects inside scattering media at diffraction-limited resolution. However, SCI methods are currently limited to imaging sparsely tagged objects in a dark-field scenario. In this work, we demonstrate the ability to image hidden, moving objects in a bright-field scenario...
February 20, 2017: Optics Express
Kathleen McGarvey-Lechable, Tabassom Hamidfar, David Patel, Luhua Xu, David V Plant, Pablo Bianucci
We present experimental results of photonic crystal ring resonators (PhCRRs) fabricated on the CMOS-compatible, silicon-on-insulator platform via 193-nm deep-UV lithography. Our dispersion-engineering design approach is compared to experimental results, showing very good agreement between theory and measurements. Specifically, we report a mean photonic band-edge wavelength of 1546.2 ± 5.8 nm, a 0.2% variation from our targeted band-edge wavelength of 1550 nm. Methods for the direct calculation of the experimental, discrete dispersion relation and extraction of intrinsic quality factors for a highly-dispersive resonator are discussed...
February 20, 2017: Optics Express
F Schlaepfer, A Ludwig, M Lucchini, L Kasmi, M Volkov, L Gallmann, U Keller
Attosecond pump-probe measurements are typically performed by combining attosecond pulses with more intense femtosecond, phase-locked infrared (IR) pulses because of the low average photon flux of attosecond light sources based on high-harmonic generation (HHG). Furthermore, the strong absorption of materials at the extreme ultraviolet (XUV) wavelengths of the attosecond pulses typically prevents the use of transmissive optics. As a result, pump and probe beams are typically recombined geometrically with a center-hole mirror that reflects the larger IR beam and transmits the smaller XUV, which leads to an annular beam profile of the IR...
February 20, 2017: Optics Express
Tianhua Xu, Nikita A Shevchenko, Domaniç Lavery, Daniel Semrau, Gabriele Liga, Alex Alvarado, Robert I Killey, Polina Bayvel
The relationship between modulation format and the performance of multi-channel digital back-propagation (MC-DBP) in ideal Nyquist-spaced optical communication systems is investigated. It is found that the nonlinear distortions behave independent of modulation format in the case of full-field DBP, in contrast to the cases of electronic dispersion compensation and partial-bandwidth DBP. It is shown that the minimum number of steps per span required for MC-DBP depends on the chosen modulation format. For any given target information rate, there exists a possible trade-off between modulation format and back-propagated bandwidth, which could be used to reduce the computational complexity requirement of MC-DBP...
February 20, 2017: Optics Express
Rita Restano-Cassulini, Walter Garcia, Jorge F Paniagua-Solís, Lourival D Possani
Scorpion stings on humans are medically relevant because they may contain toxins that specifically target ion channels. During antivenom production, pharmaceutical companies must use a large number of experimental animals to ensure the antivenom's efficacy according to pharmacopeia methods. Here we present an electrophysiological alternative for the evaluation of horse antivenoms produced against two species of Moroccan scorpions: Buthus mardochei and Androctonus mauretanicus. Human sodium and potassium channels and acetylcholine nicotinic receptors were analyzed by standard patch-clamp techniques...
February 23, 2017: Toxins
Luxi Jiang, Hongyu Ren, Haijian Zhou, Tian Qin, Yu Chen
Early diagnosis and treatment are crucial to the outcome of lower respiratory tract infections (LRTIs). In this study, we developed an assay combining multiplex PCR and Luminex technology (MPLT) for the detection of nine important respiratory bacterial pathogens, which frequently cause LRTIs. These were Streptococcus pneumoniae, Moraxella catarrhalis, Staphylococcus aureus, Streptococcus pyogenes, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella spp., Pseudomonas aeruginosa, and Klebsiella pneumoniae...
February 23, 2017: International Journal of Environmental Research and Public Health
Carol R Horowitz, Khader Shameer, Janice Gabrilove, Ashish Atreja, Peggy Shepard, Crispin N Goytia, Geoffrey W Smith, Joel Dudley, Rachel Manning, Nina A Bickell, Maida P Galvez
Development and implementation of effective, sustainable, and scalable interventions that advance equity could be propelled by innovative and inclusive partnerships. Readied catalytic frameworks that foster communication, collaboration, a shared vision, and transformative translational research across scientific and non-scientific divides are needed to foster rapid generation of novel solutions to address and ultimately eliminate disparities. To achieve this, we transformed and expanded a community-academic board into a translational science board with members from public, academic and private sectors...
February 23, 2017: International Journal of Environmental Research and Public Health
Nora Schneider, Clara L Garcia-Rodenas
Adequate nutrition is important for neurodevelopmental outcomes in preterm-born infants. In this review, we aim to summarize the current knowledge on nutritional interventions initiated during the hospital stay targeting brain and cognitive development benefits in preterm human infants. Studies can broadly be split in general dietary intervention studies and studies investigating specific nutrients or nutritional supplements. In general, mother's breast milk was reported to be better for preterm infants' neurodevelopment compared to infant formula...
February 23, 2017: Nutrients
Nigel J Pyne, Susan Pyne
The bioactive lipid, sphingosine 1-phosphate (S1P) binds to a family of G protein-coupled receptors, termed S1P₁-S1P₅. These receptors function in, for example, the cardiovascular system to regulate vascular barrier integrity and tone, the nervous system to regulate neuronal differentiation, myelination and oligodendrocyte/glial cell survival and the immune system to regulate T- and B-cell subsets and trafficking. S1P receptors also participate in the pathophysiology of autoimmunity, inflammatory disease, cancer, neurodegeneration and others...
February 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Simona Serini, Gabriella Calviello
A potential complementary role of the dietary long-chain n-3 polyunsaturated fatty acids (LCn-3 PUFA) in combination with innovative mono-targeted therapies has recently been proposed. These compounds are thought to act pleiotropically to prevent the development and progression of a variety of cancers, including breast cancer. We hereinafter critically analyze the reports investigating the ability of LCn-3 PUFA to modulate the Ras/ERK and the phosphoinositide survival signaling pathways often aberrantly activated in breast cancer and representing the main targets of innovative therapies...
February 23, 2017: Nutrients
Di Yang, Bo Yu, Haiyan Sun, Lihong Qiu
Posttranslational modifications including histone methylation regulate gene transcription through directly affecting the structure of chromatin. Trimethylation of histone 3 lysine 27 (H3K27me3) is observed at the promoters of a wide variety of important genes, especially for mammalian development, and contributes to gene silencing. Demethylase Jumonji domain-containing 3 (Jmjd3) catalyzes the transition of H3K27me3 to H3K27me1, therefore from a repressive to an active status of gene expression. Jmjd3 plays important roles in cell differentiation, inflammation, and tumorigenesis by targeting distinct transcription factors...
February 23, 2017: Journal of Clinical Medicine
Yoosoo Jeong, Daejin Park, Kil Houm Park
This paper presents a pan-tilt-zoom (PTZ) camera-based displacement measurement system, specially based on the perspective distortion correction technique for the early detection of building destruction. The proposed PTZ-based vision system rotates the camera to monitor the specific targets from various distances and controls the zoom level of the lens for a constant field of view (FOV). The proposed approach adopts perspective distortion correction to expand the measurable range in monitoring the displacement of the target structure...
February 23, 2017: Sensors
Allison H Williams, Richard Wheeler, Constance Thiriau, Ahmed Haouz, Muhamed-Kheir Taha, Ivo G Boneca
Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram-negative bacteria. Bulgecin A is an O-sulphonated glycopeptide that targets primarily soluble lytic tranglycosylases (Slt). It has been shown that bulgecin A increases the efficacy of β-lactams that target penicillin bindings proteins (PBPs). Here, we present the high-resolution crystal structure of LtgA from Neisseria meningitidis strain MC58, a membrane bound homolog of Escherichia coli Slt, in complex with bulgecin A...
February 22, 2017: Antibiotics
Leonardo M Rodrigues, Carlos Montez, Ricardo Moraes, Paulo Portugal, Francisco Vasques
Energy consumption is a major issue in Wireless Sensor Networks (WSNs), as nodes are powered by chemical batteries with an upper bounded lifetime. Estimating the lifetime of batteries is a difficult task, as it depends on several factors, such as operating temperatures and discharge rates. Analytical battery models can be used for estimating both the battery lifetime and the voltage behavior over time. Still, available models usually do not consider the impact of operating temperatures on the battery behavior...
February 22, 2017: Sensors
Dario Novak, Lovro Štefan, Rebeka Prosoli, Arunas Emeljanovas, Brigita Mieziene, Ivana Milanović, Snežana Radisavljević-Janić
Little is known about the factors which might influence the adherence to a Mediterranean diet in non-Mediterranean European countries. Thus, the main purpose of this study was to determine the associations between socioeconomic, psychological, and physical factors on a Mediterranean diet. In this cross-sectional study, participants were 14-18-year-old adolescents (N = 3071) from two non-Mediterranean countries: Lithuania (N = 1863) and Serbia (N = 1208). The dependent variable was Mediterranean diet, and was assessed with the Mediterranean Diet Quality Index for children and adolescents questionnaire...
February 22, 2017: Nutrients
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