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https://www.readbyqxmd.com/read/29752870/morphological-and-cellular-characterization-of-the-fetal-canine-canis-lupus-familiaris-subventricular-zone-rostral-migratory-stream-and-olfactory-bulb
#1
Dailiany Orechio, Bruna Andrade Aguiar, Giovanne Baroni Diniz, Jackson Cioni Bittencourt, Carlos A Haemmerle, Ii-Sei Watanabe, Maria Angelica Miglino, Patricia Castelucci
The existence of neurogenesis in the adult brain is a widely recognized phenomenon, occurring in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone of the dentate gyrus in several vertebrate species. Neural precursors originated in the SVZ migrate to the main olfactory bulb (MOB), originating the rostral migratory stream (RMS) in the process. To better understand the formation of the adult neurogenic niches in dogs, we investigated the cellular composition and morphological organization of these areas in 57 days-old dog fetuses...
May 12, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29712784/temporal-response-properties-of-accessory-olfactory-bulb-neurons-limitations-and-opportunities-for-decoding
#2
Michal Yoles-Frenkel, Anat Kahan, Yoram Ben-Shaul
The vomeronasal system (VNS) is a major vertebrate chemosensory system that functions in parallel to the main olfactory system (MOS). Despite many similarities, the two systems dramatically differ in the temporal domain. While MOS responses are governed by breathing and follow a sub-second temporal scale, VNS responses are uncoupled from breathing and evolve over seconds. This suggests that the contribution of response dynamics to stimulus information will differ between these systems. While temporal dynamics in the MOS are widely investigated, similar analyses in the AOB are lacking...
April 30, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29691860/outbreaks-of-diarrhoea-winter-scours-in-weaned-merino-sheep-in-south-eastern-australia
#3
K J Stanger, H McGregor, Jwa Larsen
OBJECTIVE: Identify the cause of outbreaks of diarrhoea during winter that are not attributable to gastrointestinal nematodes in weaned Merino sheep in the high rainfall regions of south-eastern Australia and determine the efficacy of antimicrobials used to treat this syndrome. METHODS: We investigated 45 outbreaks on 24 farms. Faecal samples from affected animals were cultured for Yersinia, Campylobacter and Salmonella spp. Risk factors, including rainfall, temperature and worm egg count (WEC), were assessed...
May 2018: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29678026/using-model-based-recursive-partitioning-for-treatment-subgroup-interactions-detection-in-real-world-data-a-myocardial-infarction-case-study
#4
Tiange Chen, Xiang Li, Jingang Yang, Jingyi Hu, Meilin Xu, Yong Qin, Yuejin Yang
The effects of treatment often vary over subpopulations characterized by baseline patient features. Detection of such treatment-subgroup interaction is of central importance to precision medicine and personalized care. In this paper, we propose an analytical framework for treatment-subgroup interactions detection and treatment effectiveness heterogeneity evaluation in a real-world data setting. Model-based recursive partitioning analysis (MOB) is used for subgroup identification, filter-based confounder selection and multivariate logistic regression are used for confounding reduction and treatment effectiveness assessment...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29674028/a-novel-surface-enhanced-raman-scattering-sers-detection-for-natural-gas-exploration-using-methane-oxidizing-bacteria
#5
Weiwei Liang, Qiao Chen, Fang Peng, Aiguo Shen, Jiming Hu
Methane-oxidizing bacteria (MOB), a unique group of Gram-negative bacteria utilizing methane as a sole source of carbon and energy, have been proved to be a biological indicator for gas prospecting. Field and cultivation-free detection of MOB is important but still challenging in current microbial prospecting of oil and gas (MPOG) system. Herein, SERS was used for the first time to our knowledge to investigate two species of methanotrophs and four closely relevant bacteria that universally coexisted in the upper soil of natural gas...
July 1, 2018: Talanta
https://www.readbyqxmd.com/read/29667923/autoethnography-and-cognitive-adaptation-two-powerful-buffers-against-the-negative-consequences-of-workplace-bullying-and-academic-mobbing
#6
Mpho M Pheko
Work is undoubtedly fundamental to human life, social development and the economic development of individuals, organizations and nations. However, the experience of working is not always pleasant as there are many instances where relationships between workers could deteriorate, leading to practices and behaviours that could be characterized as workplace bullying and/or mobbing. The current study is an exploratory study which used autoethnography to investigate experiences of academic bullying and mobbing, and relates the practices to power structures in academic institutions...
December 2018: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29615256/f14-a-b-and-incx4-inc-group-cfr-positive-plasmids-circulating-in-escherichia-coli-of-animal-origin-in-northeast-china
#7
Xiumei Wang, Yao Zhu, Xin Hua, Fuguang Chen, Changzhen Wang, Yanhe Zhang, Siguo Liu, Wanjiang Zhang
The objective of this study was to investigate the prevalence of the cfr gene in Escherichia coli isolates from domestic animals in Northeast China and to characterize the cfr-containing plasmids. Between June 2015 and April 2016, 370 E. coli isolates were collected from pigs, chickens, and dairy cows in Northeast China. Among these, 111 were florfenicol resistant, including 109 isolates carrying the floR gene and 6 positives for cfr. The prevalence of cfr in E. coli isolates from the four northeast provinces in China was 1...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29600559/altering-neurospora-crassa-mob2a-exposes-its-functions-in-development-and-affects-its-interaction-with-the-ndr-kinase-cot1
#8
Liran Aharoni-Kats, Einat Zelinger, She Chen, Oded Yarden
The Neurospora crassa Mps One Binder (MOB) proteins MOB2A and MOB2B physically interact with the Nuclear Dbf2 Related (NDR) kinase COT1 and have been shown to have overlapping functions in various aspects of asexual development. Here, we identified two N. crassa MOB2A residues, Tyr117 and Tyr119, which are potentially phosphorylated. Using phospho-mimetic mob-2a mutants we have been able to establish that apart from their previously described roles, MOB2A/B are involved in additional developmental processes...
March 30, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29595092/comparative-safety-evaluation-of-riot-control-agents-of-synthetic-and-natural-origin
#9
Ravindra M Satpute, Pramod K Kushwaha, D P Nagar, P V L Rao
Riot control agents (RCA) are lachrymatory, irritating compounds which temporarily incapacitate the uncontainable crowd. Ortho-Chlorobenzylidene-malononitrile (CS), 2-chloroacetophenone (CN), dibenz[b,f]1:4-oxazepine (CR), and nonivamide (PAVA) are synthetic RCAs, while oleoresin extract of chili known as oleoresin capsicum (OC) a natural irritant has been in use by various law enforcement agencies. Though efficacy of these agents is beyond doubt, they suffer from certain drawbacks including toxicity, production cost, and ecological compatibility...
February 2018: Inhalation Toxicology
https://www.readbyqxmd.com/read/29589282/haploinsufficiency-of-six3-abolishes-male-reproductive-behavior-through-disrupted-olfactory-development-and-impairs-female-fertility-through-disrupted-gnrh-neuron-migration
#10
Erica C Pandolfi, Hanne M Hoffmann, Erica L Schoeller, Michael R Gorman, Pamela L Mellon
Mating behavior in males and females is dependent on olfactory cues processed through both the main olfactory epithelium (MOE) and the vomeronasal organ (VNO). Signaling through the MOE is critical for the initiation of male mating behavior, and the loss of MOE signaling severely compromises this comportment. Here, we demonstrate that dosage of the homeodomain gene Six3 affects the degree of development of MOE but not the VNO. Anomalous MOE development in Six3 heterozygote mice leads to hyposmia, specifically disrupting male mounting behavior by impairing detection of volatile female estrus pheromones...
March 27, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29552725/age-dependent-decrease-in-glomeruli-and-receptor-cells-containing-%C3%AE-1-2-fucose-glycan-in-the-mouse-main-olfactory-system-but-not-in-the-vomeronasal-system
#11
Daisuke Kondoh, Motoki Sasaki, Nobuo Kitamura
Receptor cells of the olfactory epithelium (OE) and vomeronasal organ (VNO) project axons to glomeruli in the main olfactory bulb (MOB) and accessory olfactory bulb (AOB), respectively and undergo continuous turnover throughout life. Alpha1-2 fucose (α1-2Fuc) glycan mediates neurite outgrowth and synaptic plasticity and plays important roles in the formation of the olfactory system during development. We previously confirmed the localization of α1-2Fuc glycan in the olfactory system of 3- to 4-month-old mice but whether such localization persists throughout life remains unknown...
March 19, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29552181/monopolar-spindle-one-binder-protein-2-regulates-the-activity-of-large-tumor-suppressor-yes-associated-protein-to-inhibit-the-motility-of-smmc-7721-hepatocellular-carcinoma-cells
#12
Weicheng Zhang, Jingyuan Shen, Fengming Gu, Ying Zhang, Wenjuan Wu, Jiachun Weng, Yuexia Liao, Zijing Deng, Qing Yuan, Lu Zheng, Yu Zhang, Weigan Shen
Accumulating evidence implicates monopolar spindle-one-binder protein (MOB)2 as an inhibitor of nuclear-Dbf2-related kinase (NDR) by competing with MOB1 for interaction with NDR1/2. NDR/large tumor suppressor (LATS) kinases may function similarly to yes-associated protein (YAP) kinases and be considered as members of the Hippo core cassette. MOB2 appears to serve roles in cell survival, cell cycle progression, responses to DNA damage and cell motility. However, the underlying mechanisms involved remain unclarified...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29533635/homoisoflavonoids-are-potent-glucose-transporter-2-glut2-inhibitors-a-potential-mechanism-for-the-glucose-lowering-properties-of-polygonatum-odoratum
#13
Huijun Wang, Mark I Fowler, David J Messenger, Leon A Terry, Xuelan Gu, Luxian Zhou, Ruimin Liu, Juan Su, Songshan Shi, Jose Juan Ordaz-Ortiz, Guoping Lian, Mark J Berry, Shunchun Wang
Foods of high carbohydrate content such as sucrose or starch increase postprandial blood glucose concentrations. The glucose absorption system in the intestine comprises two components: sodium-dependent glucose transporter-1 (SGLT1) and glucose transporter 2 (GLUT2). Here five sappanin-type (SAP) homoisoflavonoids were identified as novel potent GLUT2 inhibitors, with three of them isolated from the fibrous roots of Polygonatum odoratum (Mill.) Druce. SAP homoisolflavonoids had a stronger inhibitory effect on 25 mM glucose transport (41...
March 19, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29511023/loss-of-mob1a-b-in-mice-results-in-chondrodysplasia-due-to-yap1-taz-tead-dependent-repression-of-sox9
#14
Hiroki Goto, Miki Nishio, Yoko To, Tatsuya Oishi, Yosuke Miyachi, Tomohiko Maehama, Hiroshi Nishina, Haruhiko Akiyama, Tak Wah Mak, Yuma Makii, Taku Saito, Akihiro Yasoda, Noriyuki Tsumaki, Akira Suzuki
Hippo signaling is modulated in response to cell density, external mechanical forces, and rigidity of the extracellular matrix (ECM). The Mps one binder kinase activator (MOB) adaptor proteins are core components of Hippo signaling and influence Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which are potent transcriptional regulators. YAP1/TAZ are key contributors to cartilage and bone development but the molecular mechanisms by which the Hippo pathway controls chondrogenesis are largely unknown...
March 16, 2018: Development
https://www.readbyqxmd.com/read/29500964/the-use-of-model-based-recursive-partitioning-as-an-analytic-tool-in-child-welfare
#15
Holly Thurston, Sheridan Miyamoto
Child welfare agencies are tasked with investigating allegations of child maltreatment and intervening when necessary. Researchers are turning to the field of predictive analytics to optimize data analysis and data-driven decision making. To demonstrate the utility of statistical algorithms that preceded the current predictive analytics, we used Model Based (MOB) recursive partitioning, a variant of regression analysis known as decision trees, on a dataset of cases and controls with a binary outcome of serious maltreatment (defined as hospitalization or death)...
May 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29500203/model-based-recursive-partitioning-to-identify-risk-clusters-for-metabolic-syndrome-and-its-components-findings-from-the-international-mobility-in-aging-study
#16
Catherine M Pirkle, Yan Yan Wu, Maria-Victoria Zunzunegui, José Fernando Gómez
OBJECTIVE: Conceptual models underpinning much epidemiological research on ageing acknowledge that environmental, social and biological systems interact to influence health outcomes. Recursive partitioning is a data-driven approach that allows for concurrent exploration of distinct mixtures, or clusters, of individuals that have a particular outcome. Our aim is to use recursive partitioning to examine risk clusters for metabolic syndrome (MetS) and its components, in order to identify vulnerable populations...
March 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29491990/lions-hyenas-and-mobs-oh-my
#17
Kenna D S Lehmann, Tracy M Montgomery, Sarah M MacLachlan, Jenna M Parker, Olivia S Spagnuolo, Kelsey J VandeWetering, Patrick S Bills, Kay E Holekamp
Understanding the factors that facilitate the emergence of cooperation among organisms is central to the study of social evolution. Spotted hyenas Crocuta crocuta frequently cooperate to mob lions Panthera leo , approaching the lions as a tightknit group while vocalizing loudly in an attempt to overwhelm them and drive them away. Whereas cooperative mobbing behavior has been well documented in birds and some mammals, to our knowledge it has never been described during interactions between 2 apex predators. Using a 27-year dataset, we characterize lion-hyena encounters, assess rates of mobbing behavior observed during these interactions, and inquire whether mobbing results in successful acquisition of food...
June 2017: Current Zoology
https://www.readbyqxmd.com/read/29471869/type-2-diabetes-impairs-odour-detection-olfactory-memory-and-olfactory-neuroplasticity-effects-partly-reversed-by-the-dpp-4-inhibitor-linagliptin
#18
Grazyna Lietzau, William Davidsson, Claes-Göran Östenson, Fausto Chiazza, David Nathanson, Hiranya Pintana, Josefin Skogsberg, Thomas Klein, Thomas Nyström, Vladimer Darsalia, Cesare Patrone
Recent data suggest that olfactory deficits could represent an early marker and a pathogenic mechanism at the basis of cognitive decline in type 2 diabetes (T2D). However, research is needed to further characterize olfactory deficits in diabetes, their relation to cognitive decline and underlying mechanisms.The aim of this study was to determine whether T2D impairs odour detection, olfactory memory as well as neuroplasticity in two major brain areas responsible for olfaction and odour coding: the main olfactory bulb (MOB) and the piriform cortex (PC), respectively...
February 23, 2018: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/29457282/a-simple-general-synthetic-route-toward-nanoscale-transition-metal-borides
#19
Palani R Jothi, Kunio Yubuta, Boniface P T Fokwa
Most nanomaterials, such as transition metal carbides, phosphides, nitrides, chalcogenides, etc., have been extensively studied for their various properties in recent years. The similarly attractive transition metal borides, on the contrary, have seen little interest from the materials science community, mainly because nanomaterials are notoriously difficult to synthesize. Herein, a simple, general synthetic method toward crystalline transition metal boride nanomaterials is proposed. This new method takes advantage of the redox chemistry of Sn/SnCl2 , the volatility and recrystallization of SnCl2 at the synthesis conditions, as well as the immiscibility of tin with boron, to produce crystalline phases of 3d, 4d, and 5d transition metal nanoborides with different morphologies (nanorods, nanosheets, nanoprisms, nanoplates, nanoparticles, etc...
April 2018: Advanced Materials
https://www.readbyqxmd.com/read/29448156/improved-methane-removal-in-exhaust-gas-from-biogas-upgrading-process-using-immobilized-methane-oxidizing-bacteria
#20
Meng-Ting Sun, Zhi-Man Yang, Shan-Fei Fu, Xiao-Lei Fan, Rong-Bo Guo
Methane in exhaust gas from biogas upgrading process, which is a greenhouse gas, could cause global warming. The biofilter with immobilized methane-oxidizing bacteria (MOB) is a promising approach for methane removal, and the selections of inoculated MOB culture and support material are vital for the biofilter. In this work, five MOB consortia were enriched at different methane concentrations. The MOB-20 consortium enriched at the methane concentration of 20.0% (v/v) was then immobilized on sponge and two particle sizes of volcanic rock in biofilters to remove methane in exhaust gas from biogas upgrading process...
May 2018: Bioresource Technology
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