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Iliana Serifi, Eleni Tzima, Katerina Soupsana, Zoe Karetsou, Dimitris Beis, Thomais Papamarcaki
The oncoprotein SET/I2PP2A participates in various cellular mechanisms such as transcription, cell cycle regulation and cell migration. SET is also an inhibitor of the serine/threonine phosphatase PP2A, which is involved in the regulation of cell homeostasis. In zebrafish there are two paralogous set genes that encode Seta (269 aa) and Setb (275 aa) proteins which share 94% identity. We show here that seta and set b are similarly expressed in the eye, the otic vesicle, the brain and the lateral line system, as indicated by in situ hybridization labeling...
October 17, 2016: Biochemical Journal
B Dal Pupo, M Zanon, A W Tech, L V Cruz, M Cornelli, C do Valle Pereira, J Bertoglio, C Acosta, P Perusato, A J C Monteiro, G Marinho, A P S Souza, C D Garcia
BACKGROUND: Today, Brazil is the second country of the world in number of transplants. Nonetheless, waiting lists are getting longer. This lack of organs occurs mostly because of people's reduced knowledge about the donation process. With the aim of changing this scenario, in 2013 and 2014, "Organ Donation Week" events were held at the Federal University of Health Sciences of Porto Alegre. METHODS: During the 2 years, documentaries followed by a cycle of debates with experts in this area were exhibited...
September 2016: Transplantation Proceedings
Natalia Królikowska, Jakub Szymkowiak, Rebecca Anne Laidlaw, Lechosław Kuczyński
Birds exhibit various forms of anti-predator behaviours to avoid reproductive failure, with mobbing-observation, approach and usually harassment of a predator-being one of the most commonly observed. Here, we investigate patterns of temporal variation in the mobbing response exhibited by a precocial species, the northern lapwing (Vanellus vanellus). We test whether brood age and self-reliance, or the perceived risk posed by various predators, affect mobbing response of lapwings. We quantified aggressive interactions between lapwings and their natural avian predators and used generalized additive models to test how timing and predator species identity are related to the mobbing response of lapwings...
2016: Acta Ethologica
Hsing-Hua Tsai, Shao-Chiang Chang, Cheng-Hsien Chou, Tzu-Pin Weng, Chih-Chin Hsu, Jong-Shyan Wang
This study elucidates how interval and continuous exercise regimens affect the mitochondrial functionality of lymphocytes under hypoxic stress. Sixty healthy sedentary males were randomly assigned to engage in either high-intensity interval training (HIIT, 3 min intervals at 80% and 40% VO2max, n = 20) or moderate-intensity continuous training (MICT, sustained 60% VO2max, n = 20) for 30 min/day, 5 days/week for 6 weeks or were assigned to a control group that did not receive exercise intervention (n = 20)...
October 12, 2016: Scientific Reports
Chia-Hao Weng, Day-Shin Hsu, Chun-Chen Liao
Total syntheses of ent-penicillones A (ent-1) and B (ent-2) from 3,5-dimethylcatechol (3) were accomplished in ten and nine synthetic steps, respectively. A carbohydrate-templated asymmetric intramolecular Diels-Alder reaction of a masked o-benzoquinone (MOB) 9 and an aqueous acid-catalyzed intramolecular aldol reaction are the key synthetic steps. In addition, the absolute configurations of the bicyclo[2.2.2]oct-5-en-2-one core obtained from the per-O-benzylated alpha-D-glucopyranosyl as a carbohydrate template in the intramolecular Diels-Alder reaction of MOBs were revised...
October 10, 2016: Journal of Organic Chemistry
J L Pedersen, P U Pedersen, E M Damsgaard
OBJECTIVES: To compare the effects of two nutritional follow-up interventions with regard to preventing short-term deterioration in ADL, and to compare their effects on physical function, emotional health, and health-related quality of life. DESIGN: Randomized clinical trial with two intervention groups and one control group, and a follow-up period of eight weeks. SETTING: Intervention in the participants' homes after discharge from hospital...
2016: Journal of Nutrition, Health & Aging
Sang-Yong Son, Long-Hai Cui, Ho-Jung Shin, Cheulsu Byun, Hoon Hur, Sang-Uk Han, Yong Kwan Cho
BACKGROUND: Compared to end-to-side anastomosis with a circular stapler, the overlap method is favored for intracorporeal esophagojejunostomy because it facilitates handling of the stapler, even in narrow spaces, and wider anastomosis. However, it associates with technical difficulties during anastomosis, including difficult traction on the esophageal stump that necessitates stay sutures. Here, we introduce a new modified overlap method that employs knotless barbed sutures (MOBS) and report the outcomes of our case series...
October 3, 2016: Surgical Endoscopy
Huaiqing Deng, Kai Gao, Jiang Zhou
Alarm calls are important defensive behaviors. Here, we report the acoustic spectrum characteristics of alarm calls produced by Hainan gibbons (Nomascus hainanus) inhabiting Bawangling National Nature Reserve in Hainan, China. Analysis of call data collected from 2002-2014 shows that alarm calls are emitted by all family group members, except infants. Alarm behavior included simple short alarming calls (7-10 min) followed by longer variable-frequency mobbing calls lasting 5-12 min. The duration of individual alarming and mobbing calls was 0...
September 30, 2016: Scientific Reports
Martina Cappelletti, Daniele Ghezzi, Davide Zannoni, Bruno Capaccioni, Stefano Fedi
"Terre Calde di Medolla" (TCM) (literally, "Hot Lands of Medolla") refers to a farming area in Italy with anomalously high temperatures and diffuse emissions of biogenic CO2, which has been linked to CH4 oxidation processes from a depth of 0.7 m to the surface. We herein assessed the composition of the total bacterial community and diversity of methane-oxidizing bacteria (MOB) in soil samples collected at a depth at which the peak temperature was detected (0.6 m). Cultivation-independent methods were used, such as: i) a clone library analysis of the 16S rRNA gene and pmoA (coding for the α-subunit of the particulate methane monooxygenase) gene, and ii) Terminal Restriction Fragment Length Polymorphism (T-RFLP) fingerprinting...
September 17, 2016: Microbes and Environments
Kylie D Allen, Robert H White
In a non-targeted analysis of thiol-containing compounds in the hyperthermophilic methanogen Methanocaldococcus jannaschii, we discovered three unexpected metabolites: 3-mercaptopropionic acid (MPA), 2-hydroxy-4-mercaptobutyric acid (HMBA) and 4-mercapto-2-oxobutyric acid (MOB). HMBA and MOB have never been reported as natural products, while MPA is highly prevalent in aquatic environments as a result of biotic and abiotic processing of sulfur-containing compounds. This report provides evidence that HMBA and MOB are part of a biosynthetic pathway to generate MPA in M...
October 2016: FEMS Microbiology Letters
Fu-Wen Zhou, Hong-Wei Dong, Matthew Ennis
The main olfactory bulb (MOB) receives a rich noradrenergic innervation from the nucleus locus coeruleus. Despite the well documented role of norepinephrine and beta (β) adrenergic receptors in neonatal odor preference learning, identified cellular physiological actions of β receptors in the MOB have remained elusive. β receptors are expressed at relatively high levels in the MOB glomeruli, the location of external tufted (ET) cells that exert an excitatory drive on mitral and other cell types. The present study investigated the effects of β receptor activation on the excitability of ET cells using patch clamp electrophysiology in mature mouse MOB slices...
September 14, 2016: Journal of Neurophysiology
Jose Lachat, Daniel Haag-Wackernagel
When searching for food, foraging fishes expose themselves to hidden predators. The strategies that maximize the survival of foraging fishes are not well understood. Here, we describe a novel type of mobbing behaviour displayed by foraging Scolopsis affinis. The fish direct sharp water jets towards the hidden sessile annelid predator Eunice aphroditois (Bobbit worm). We recognized two different behavioural roles for mobbers (i.e., initiator and subsequent participants). The first individual to exhibit behaviour indicating the discovery of the Bobbit directed, absolutely and per time unit, more water jets than the subsequent individuals that joined the mobbing...
2016: Scientific Reports
Silvia Darb-Esfahani, Carsten Denkert, Albrecht Stenzinger, Christoph Salat, Bruno Sinn, Christian Schem, Volker Endris, Peter Klare, Wolfgang Schmitt, Jens-Uwe Blohmer, Wilko Weichert, Markus Möbs, Hans Tesch, Sherko Kümmel, Peter Sinn, Christian Jackisch, Manfred Dietel, Toralf Reimer, Sherene Loi, Michael Untch, Gunter von Minckwitz, Valentina Nekljudova, Sibylle Loibl
BACKGROUND: TP53 mutations are frequent in breast cancer, however their clinical relevance in terms of response to chemotherapy is controversial. METHODS: 450 pre-therapeutic, formalin-fixed, paraffin-embedded core biopsies from the phase II neoadjuvant GeparSixto trial that included HER2-positive and triple negative breast cancer (TNBC) were subjected to Sanger sequencing of exons 5-8 of the TP53 gene. TP53 status was correlated to response to neoadjuvant anthracycline/taxane-based chemotherapy with or without carboplatin and trastuzumab/lapatinib in HER2-positive and bevacizumab in TNBC...
September 7, 2016: Oncotarget
Xiao-Juan Chen, Hui-Qun Zhou, Hai-Bo Ye, Chun-Yan Li, Wei-Tian Zhang
Olfactory dysfunction is a common clinical phenomenon observed in various liver diseases. Previous studies have shown a correlation between smell disorders and bilirubin levels in patients with hepatic diseases. Bilirubin is a well-known neurotoxin; however, its effect on neurons in the main olfactory bulb (MOB), the first relay in the olfactory system, has not been examined. We investigated the effect of bilirubin (>3 μM) on mitral cells (MCs), the principal output neurons of the MOB. Bilirubin increased the frequency of spontaneous firing and the frequency but not the amplitude of spontaneous excitatory postsynaptic currents (sEPSCs)...
2016: Scientific Reports
Adrian Ho, Roey Angel, Annelies J Veraart, Anne Daebeler, Zhongjun Jia, Sang Yoon Kim, Frederiek-Maarten Kerckhof, Nico Boon, Paul L E Bodelier
Microbial interaction is an integral component of microbial ecology studies, yet the role, extent, and relevance of microbial interaction in community functioning remains unclear, particularly in the context of global biogeochemical cycles. While many studies have shed light on the physico-chemical cues affecting specific processes, (micro)biotic controls and interactions potentially steering microbial communities leading to altered functioning are less known. Yet, recent accumulating evidence suggests that the concerted actions of a community can be significantly different from the combined effects of individual microorganisms, giving rise to emergent properties...
2016: Frontiers in Microbiology
Oswaldo Sinoe Medina-Gómez
INTRODUCTION: In Mexico there is little research to know the magnitude of mobbing. OBJECTIVE: To identify the prevalence of mobbing and characteristics associated in workers. MATERIAL AND METHODS: A cross-sectional study of 499 workers who use medical unit. A questionnaire was used to determine the presence of mobbing and various instruments to know the personality, vulnerability to stress, self-esteem and depression. Prevalence odds ratio, dispersion, chi-square and Poisson regression were calculated...
July 2016: Gaceta Médica de México
Iraida Gimeno Pi, M Luisa Guitard Sein-Echaluce, Lluís Rosselló Aubach, Joan Torres Puig-Gros, Joaquim Fernández Solà
BACKGROUND: Chronic Fatigue Syndrome (CFS) is a complex and multifactorial disease. Stressful situations experienced could be related to the presentation of the disease. Few studies have determined which factors could trigger CFS. The main objective of this study was to explore the stressful situations which can be associated with CFS presentation. METHODS: Retrospective observational case-control study with CFS diagnosed patients according to the Fukuda's criteria...
2016: Revista Española de Salud Pública
Ana Lúcia da Silva João, António Fernando Saldanha Portelada
Mobbing is characterized by the repetition, over a long period of time, of hostile behavior and unethical conduct carried out by a hierarchical superior or co-worker, against someone's physic and mental integrity, endangering one's job or disturbing the work environment. This current investigative study intends to assess the existence, frequency, and intensity of mobbing within the Portuguese nurse population, as well as its impact on their well-being and interpersonal relationships. The study carried out was quantitative, correlational, and cross-sectional...
August 12, 2016: Journal of Interpersonal Violence
Yves Libert, Stéphanie Dubruille, Cindy Borghgraef, Anne-Marie Etienne, Isabelle Merckaert, Marianne Paesmans, Christine Reynaert, Myriam Roos, Jean-Louis Slachmuylder, Sandrine Vandenbossche, Dominique Bron, Darius Razavi
INTRODUCTION: Dementia is a known predictor of shorter survival times in older cancer patients. However, no empirical evidence is available to determine how much a cognitive impairment shortens survival in older patients when cancer treatment is initiated. PURPOSE: To longitudinally investigate how much a cognitive impairment detected at the initiation of cancer treatment influences survival of older patients during a two-year follow-up duration and to compare the predictive value of a cognitive impairment on patients survival with the predictive value of other vulnerabilities associated with older age...
2016: PloS One
John A Batsis, Julie P W Bynum
OBJECTIVE: To assess the use of the Medicare Obesity Benefit (MOB) by a licensed physician or associate provider in an outpatient setting in older adults. METHODS: A serial cross-sectional analysis of fee-for-service Medicare claims (2012 and 2013) was used to assess the use of the MOB. Number and proportion of Medicare beneficiaries over age 65 using the benefit were assessed. Correlation between state-obesity rates and MOB uptake was determined based on state-specific obesity prevalence data from the Behavioral Risk Factor Surveillance System...
September 2016: Obesity
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