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https://www.readbyqxmd.com/read/29330294/establishment-of-the-first-well-differentiated-human-pancreatic-neuroendocrine-tumor-model
#1
Daniel Benten, Yasmin Behrang, Ludmilla Unrau, Victoria Weissmann, Gerrit Wolters-Eisfeld, Susanne Burdak-Rothkamm, Felix R Stahl, Martin Anlauf, Patricia Grabowski, Markus Möbs, Jan Dieckhoff, Bence Sipos, Martina Fahl, Corinna Eggers, Daniel Perez, Maximilian Bockhorn, Jakob R Izbicki, Ansgar W Lohse, Joerg Schrader
Clinical options for systemic therapy of neuroendocrine tumors (NET) are limited. Development of new drugs requires suitable representative in vitro and in vivo model systems. So far, the unavailability of a human model with a well-differentiated phenotype and typical growth characteristics has impaired pre-clinical research in NET. Herein, we establish and characterize a lymph node-derived cell line (NT-3) from a male patient with well-differentiated pancreatic NET. Neuroendocrine differentiation and tumor biology was compared to existing NET cell lines BON and QGP-1...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29322885/analysis-of-a-15-years-experience-in-including-shoulder-muscles-when-treating-upper-limb-spasticity-post-stroke-with-botulinum-toxin-type-a
#2
Maria Pais de Carvalho, Daniela Pinto, Melissa Gorayeb, Jorge Jacinto
Background Botulinum toxin type-A (BoNTA) is a recognized treatment for upper limb spasticity (ULS) after stroke, but there aren't many studies analyzing its effect in shoulder muscles. Objective To evaluate the efficacy of BoNTA injections for ULS, when shoulder muscles are included. Methods A cross-sectional study. Data from clinical forms of outpatients, treated at a Rehabilitation Center (2001-2016). Analyzes: goals of treatment; demographic characteristics/goal; treatment success, using Goal Attainment Scaling...
January 11, 2018: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29319741/verbal-abuse-and-mobbing-in-pre-hospital-care-services-in-chile
#3
Varinia Rodríguez Campo, Tatiana Paravic Klijn
OBJECTIVE: to determine the perception of verbal abuse and mobbing and the associated factors of paramedic technicians (nursing assistants) and professionals (nurses, midwives, kinesiologists) in the pre-hospital care areas of three regions in the south of Chile. METHODS: descriptive and correlational study was performed within the professional community and a two-stage sample of the paramedic technician population in three regions. The questionnaire "workplace violence in the health sector" (spanish version) was applied after signing the informed consent...
January 8, 2018: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29316140/a-male-gametocyte-osmiophilic-body-and-microgamete-surface-protein-of-the-rodent-malaria-parasite-plasmodium-yoelii-pymigs-plays-a-critical-role-in-male-osmiophilic-body-formation-and-exflagellation
#4
Mayumi Tachibana, Tomoko Ishino, Eizo Takashima, Takafumi Tsuboi, Motomi Torii
Anopheles mosquitoes transmit Plasmodium parasites of mammals, including the species that cause malaria in humans. Malaria pathology is caused by rapid multiplication of parasites in asexual intraerythrocytic cycles. Sexual stage parasites are also produced during the intraerythrocytic cycle, and are ingested by the mosquito, initiating gametogenesis and subsequent sporogonic stage development. Here, we present a Plasmodium protein, termed microgamete surface protein (MiGS), which has an important role in male gametocyte osmiophilic body (MOB) formation and microgamete function...
January 5, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29303410/relationship-of-nutrient-dynamics-and-bacterial-community-structure-at-the-water-sediment-interface-using-a-benthic-chamber-experiment
#5
Bo-Min Ki, In Ae Huh, Jung-Hyun Choi, Kyung-Suk Cho
The relationships between nutrient dynamics and the bacterial community at the water-sediment interface were investigated using the results of nutrient release fluxes, bacterial communities examined by 16S rRNA pyrosequencing and canonical correlation analysis (CCA) accompanied by lab-scale benthic chamber experiment. The nutrient release fluxes from the sediments into the water were as follows: -3.832 to 12.157 mg m-2 d-1 for total phosphorus, 0.049 to 9.993 mg m-2 d-1 for PO4-P, -2.011 to 41.699 mg m-2 d-1 for total nitrogen, -7...
January 5, 2018: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29295972/trapping-ige-in-a-closed-conformation-by-mimicking-cd23-binding-prevents-and-disrupts-fc%C3%AE%C2%B5ri-interaction
#6
Frederic Jabs, Melanie Plum, Nick S Laursen, Rasmus K Jensen, Brian Mølgaard, Michaela Miehe, Marco Mandolesi, Michèle M Rauber, Wolfgang Pfützner, Thilo Jakob, Christian Möbs, Gregers R Andersen, Edzard Spillner
Anti-IgE therapeutics interfere with the ability of IgE to bind to its receptors on effector cells. Here we report the crystal structure of an anti-IgE single-domain antibody in complex with an IgE Fc fragment, revealing how the antibody inhibits interactions between IgE and the two receptors FcεRI and CD23. The epitope overlaps only slightly with the FcεRI-binding site but significantly with the CD23-binding site. Solution scattering studies of the IgE Fc reveal that antibody binding induces a half-bent conformation in between the well-known bent and extended IgE Fc conformations...
January 2, 2018: Nature Communications
https://www.readbyqxmd.com/read/29250047/the-different-faces-of-rolling-circle-replication-and-its-multifunctional-initiator-proteins
#7
REVIEW
Paweł Wawrzyniak, Grażyna Płucienniczak, Dariusz Bartosik
Horizontal gene transfer (HGT) contributes greatly to the plasticity and evolution of prokaryotic and eukaryotic genomes. The main carriers of foreign DNA in HGT are mobile genetic elements (MGEs) that have extremely diverse genetic structures and properties. Various strategies are used for the maintenance and spread of MGEs, including (i) vegetative replication, (ii) transposition (and other types of recombination), and (iii) conjugal transfer. In many MGEs, all of these processes are dependent on rolling-circle replication (RCR)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29228593/proteasome-inhibitor-bortezomib-enhances-the-effect-of-standard-chemotherapy-in-small-cell-lung-cancer
#8
Sanaz Taromi, Florentine Lewens, Ruza Arsenic, Dagmar Sedding, Jörg Sänger, Almut Kunze, Markus Möbs, Joana Benecke, Helma Freitag, Friederike Christen, Daniel Kaemmerer, Amelie Lupp, Mareike Heilmann, Hedwig Lammert, Claus-Peter Schneider, Karen Richter, Michael Hummel, Britta Siegmund, Meike Burger, Franziska Briest, Patricia Grabowski
Small cell lung cancer (SCLC) is an aggressive cancer showing a very poor prognosis because of metastasis formation at an early stage and acquisition of chemoresistance. One key driver of chemoresistance is the transcription factor Forkhead box protein M1 (FOXM1) that regulates cell cycle proliferation, maintenance of genomic stability, DNA damage response, and cell differentiation in numerous tumor entities. In this study we investigated the role of FOXM1 in SCLC progression and analyzed the effect of FOXM1 inhibition using two proteasome inhibitors, bortezomib and siomycin A...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227871/production-of-biogenic-manganese-oxides-coupled-with-methane-oxidation-in-a-bioreactor-for-removing-metals-from-wastewater
#9
Shuji Matsushita, Daisuke Komizo, Linh Thi Thuy Cao, Yoshiteru Aoi, Tomonori Kindaichi, Noriatsu Ozaki, Hiroyuki Imachi, Akiyoshi Ohashi
Biogenic manganese oxide (BioMnOx) can efficiently adsorb various minor metals. The production of BioMnOx in reactors to remove metals during wastewater treatment processes is a promising biotechnological method. However, it is difficult to preferentially enrich manganese-oxidizing bacteria (MnOB) to produce BioMnOx during wastewater treatment processes. A unique method of cultivating MnOB using methane-oxidizing bacteria (MOB) to produce soluble microbial products is proposed here. MnOB were successfully enriched in a methane-fed reactor containing MOB...
December 1, 2017: Water Research
https://www.readbyqxmd.com/read/29222134/workplace-violence-psychological-stress-sleep-quality-and-subjective-health-in-chinese-doctors-a-large-cross-sectional-study
#10
Tao Sun, Lei Gao, Fujun Li, Yu Shi, Fengzhe Xie, Jinghui Wang, Shuo Wang, Shue Zhang, Wenhui Liu, Xiaojian Duan, Xinyan Liu, Zhong Zhang, Li Li, Lihua Fan
BACKGROUND: Workplace violence (WPV) against healthcare workers is known as violence in healthcare settings and referring to the violent acts that are directed towards doctors, nurses or other healthcare staff at work or on duty. Moreover, WPV can cause a large number of adverse outcomes. However, there is not enough evidence to test the link between exposure to WPV against doctors, psychological stress, sleep quality and health status in China. OBJECTIVES: This study had three objectives: (1) to identify the incidence rate of WPV against doctors under a new classification, (2) to examine the association between exposure to WPV, psychological stress, sleep quality and subjective health of Chinese doctors and (3) to verify the partial mediating role of psychological stress...
December 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/29187814/olfaction-and-pheromones-uncanonical-sensory-influences-and-bulbar-interactions
#11
REVIEW
Víctor Vargas-Barroso, Fernando Peña-Ortega, Jorge A Larriva-Sahd
The rodent main and accessory olfactory systems (AOS) are considered functionally and anatomically segregated information-processing pathways. Each system is devoted to the detection of volatile odorants and pheromones, respectively. However, a growing number of evidences supports a cooperative interaction between them. For instance, at least four non-canonical receptor families (i.e., different from olfactory and vomeronasal receptor families) have been recently discovered. These atypical receptor families are expressed in the sensory organs of the nasal cavity and furnish parallel processing-pathways that detect specific stimuli and mediate specific behaviors as well...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/29187725/mobbing-bullying-at-work-in-italy-characteristics-of-successful-court-cases
#12
Daniela Acquadro Maran, Silvia Bernardelli, Antonella Varetto
BACKGROUND: Mobbing (bullying at work) refers to a form of psychological harassment that occurs in the workplace, in which the victim must be systematically and continuously persecuted for a long period of time. The aim of this work is to analyze the court judgments related to mobbing. METHODS: The data, collected from a website that included judgments from an Italian court, were analyzed according to the literature, identifying the type of victims, consequences, methods of harassment, type of mobbers, and compensation decided by the court...
November 22, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/29171032/immunological-differences-between-insect-venom-allergic-patients-with-and-without-immunotherapy-and-asymptomatically-sensitized-subjects
#13
Lisa Arzt, Danijela Bokanovic, Christoph Schrautzer, Karin Laipold, Christian Möbs, Wolfgang Pfützner, Sereina Annik Herzog, Jutta Vollmann, Norbert Reider, Barbara Bohle, Werner Aberer, Gunter Sturm
BACKGROUND: Currently available tests are unable to distinguish between asymptomatic sensitization and clinically relevant Hymenoptera venom allergy. A reliable serological marker to monitor venom immunotherapy (VIT) does also not exist. Our aim was to find reliable serological markers to predict tolerance to bee and vespid stings. METHODS: We included 77 asymptomatically-sensitized subjects, 85 allergic-patients with acute systemic sting reactions, and 61 allergic-patients currently treated with VIT...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29159964/blocking-antibodies-induced-by-allergen-specific-immunotherapy-ameliorate-allergic-airway-disease-in-a-human-mouse-chimeric-model
#14
Caterina Vizzardelli, Miriam Gindl, Simone Roos, Christian Möbs, Birgit Nagl, Felix Zimmann, Veronika Sexl, Lukas Kenner, Alina Neunkirchner, Gerhard J Zlabinger, Winfried F Pickl, Wolfgang Pfützner, Barbara Bohle
BACKGROUND: Allergen-specific immunotherapy (AIT) induces specific blocking antibodies (Ab) which are claimed to prevent IgE-mediated reactions to allergens. Additionally, AIT modulates cellular responses to allergens, e.g. by desensitizing effector cells, inducing regulatory T and B lymphocytes and immune deviation. It is still enigmatic which of these mechanisms mediate(s) clinical tolerance. We sought to address the role of AIT-induced blocking Ab separately from cellular responses in a chimeric human/mouse model of respiratory allergy...
November 21, 2017: Allergy
https://www.readbyqxmd.com/read/29139076/extended%C3%A2-spectrum%C3%A2-beta-lactamase-esbl-producing-bacteria-isolated-from-hospital-wastewaters-rivers-and-aquaculture-sources-in-nigeria
#15
Olawale Olufemi Adelowo, Serena Caucci, Omowunmi Abosede Banjo, Ozioma Chinyere Nnanna, Eunice Olubunmi Awotipe, Florence Bosede Peters, Obasola Ezekiel Fagade, Thomas U Berendonk
Untreated wastewater is a risk factor for the spread of antibiotic resistance in the environment. However, little is known about the contribution of untreated wastewater to the burden of antibiotic resistance in the Nigerian environment. In this study, a total of 143 ceftazidime-/cefpodoxime-resistant bacteria isolated from untreated wastewater and untreated wastewater-contaminated surface and groundwater in Nigeria were screened for extended-spectrum β-lactamase (ESBL) genes, integrons and integron gene cassettes by PCR...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29132960/influenza-derived-peptides-cross-react-with-allergens-and-provide-asthma-protection
#16
Chrysanthi Skevaki, Christoph Hudemann, Mikhail Matrosovich, Christian Möbs, Sinu Paul, Andreas Wachtendorf, Bilal Alashkar Alhamwe, Daniel P Potaczek, Stefanie Hagner, Diethard Gemsa, Holger Garn, Alessandro Sette, Harald Renz
BACKGROUND: The hygiene hypothesis is the leading concept to explain the current asthma epidemic, which is built on the observation that a lack of bacterial contact early in life induces allergic Th2 immune responses. OBJECTIVE: Since little is known about the contribution of respiratory viruses in this context, we evaluated the effect of prior influenza-infection on the development of allergic asthma. METHODS: Mice were infected with influenza and once recovered, subjected to an ovalbumin or house dust mite-induced experimental asthma protocol...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29119647/schottky-catalysts-boost-hydrogen-evolution-the-case-of-mob-g-c3n4-interface-materials
#17
Zechao Zhuang, Yong Li, Zilan Li, Fan Lv, Zhiquan Lang, Kangning Zhao, Liang Zhou, Lyudmila Moskaleva, Shaojun Guo, Liqiang Mai
Moderate proton adsorption on metallic catalysts is a prerequisite for efficient hydrogen evolution reaction (HER). However, precisely tuning the proton adsorption without perturbing metallicity still remains a formidable challenge. Herein, we fabricate an ingenious Schottky catalyst based on metal-semiconductor junction principles. When selecting metallic MoB as a paradigm, the introduction of n-type semiconductive g-C3N4 induces a vigorous charge transfer across the MoB/g-C3N4 Schottky junction, and increases the local electron density in MoB surface, proved by multiple spectroscopic techniques...
November 8, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29107945/neurogenesis-in-the-olfactory-bulb-induced-by-paced-mating-in-the-female-rat-is-opioid-dependent
#18
Marianela Santoyo-Zedillo, Wendy Portillo, Raúl G Paredes
The possibility to control the rate of sexual stimulation that the female rat receives during a mating encounter (pacing) increases the number of newborn neurons that reach the granular layer of the accessory olfactory bulb (AOB). If females mate repeatedly, the increase in the number of neurons is observed in other regions of the AOB and in the main olfactory bulb (MOB). It has also been shown that paced mating induces a reward state mediated by opioids. There is also evidence that opioids modulate neurogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29080488/synergistic-effects-of-biogenic-manganese-oxide-and-mn-ii-oxidizing-bacterium-pseudomonas-putida-strain-mnb1-on-the-degradation-of-17-%C3%AE-ethinylestradiol
#19
Thi Nhung Tran, Do-Gun Kim, Seok-Oh Ko
While biogenic manganese oxide (BMO) generated via the oxidation of Mn(II) by the Mn-oxidizing bacteria (MOB) have received attention, the relative roles of biological activity by MOB themselves were not clearly investigated. In this study, the synergistic effects of BMO and MOB Pseudomonas putida strain MnB1 on the degradation of 17α-ethinylestradiol (EE2) was investigated. Experiments with BMO in the presence of P. putida MnB1 showed 15-fold higher removal than that with BMO alone, suggesting that EE2 degradation was mediated by the biological activity of MOB as well as abiotic reaction by BMO...
October 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29079862/aerobic-and-anaerobic-methanotrophic-communities-in-urban-landscape-wetland
#20
Sili Chen, Jianfei Chen, Sha Chang, Hao Yi, Dawei Huang, Shuguang Xie, Qingwei Guo
Both aerobic methane-oxidizing bacteria (MOB) and nitrite-dependent anaerobic methane oxidation (n-damo) organisms can be important methane sinks in a wetland. However, the influences of the vegetation type on aerobic MOB and n-damo communities in wetland, especially in constructed wetland, remain poorly understood. The present study investigated the influences of the vegetation type on both aerobic MOB and n-damo organisms in a constructed urban landscape wetland. Sediments were collected from eight sites vegetated with different plant species...
October 28, 2017: Applied Microbiology and Biotechnology
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