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https://www.readbyqxmd.com/read/28334700/single-agent-pixantrone-as-a-bridge-to-autologous-stem-cell-transplantation-in-a-patient-with-refractory-diffuse-large-b-cell-lymphoma
#1
Lorena Appio, Carlo Landoni, Maria La Targia, Vanda Bertolli, Martina Chiarucci, Giovanni Crovetti, Elisabetta Vassenna, Giovanni Serio, Marco Bregni
Aggressive non-Hodgkin lymphoma is associated with poor long-term survival after relapse or resistance to chemotherapy. We report a case of aggressive non-Hodgkin lymphoma refractory to first-line R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) and second-line R-DHAP (rituximab, dexamethasone, cytarabine, and cisplatin) chemotherapy treatments. The patient achieved remission with single-agent pixantrone, and received a consolidation with high-dose BEAM (BCNU, etoposide, cytarabine, and melphalan) chemotherapy and autologous stem cell transplantation...
March 24, 2017: Chemotherapy
https://www.readbyqxmd.com/read/28334484/amine-transaminase-engineering-for-spatially-bulky-substrate-acceptance
#2
Uwe Bornscheuer, Martin S Weiß, Ioannis V Pavlidis, Paul Spur, Steven P Hanlon, Beat Wirz, Hans Iding
Amine transaminase (ATA) catalysing stereoselective amination of prochiral ketones is an attractive alternative to transition metal catalysis. As wild-type ATAs accept only non-sterically hindered ketones, efforts to widen the substrate scope to more challenging targets are of general interest. We recently designed ATAs to accept aromatic and thus planar bulky amines, via a sequenced based motif that supports the identification of novel enzymes. However, these variants were not active against 2,2-dimethyl-1-phenyl-propan-1-one, which carries a spatially bulky tert-butyl substituent adjacent to the carbonyl function...
March 23, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28332818/in-situ-preparation-of-metal-halide-perovskite-nanocrystal-thin-films-for-improved-light-emitting-devices
#3
Lianfeng Zhao, Yao-Wen Yeh, Nhu L Tran, Fan Wu, Zhengguo Xiao, Ross A Kerner, YunHui L Lin, Gregory D Scholes, Nan Yao, Barry P Rand
Hybrid organic-inorganic halide perovskite semiconductors are attractive candidates for optoelectronic applications, such as photovoltaics, light-emitting diodes, and lasers. Perovskite nanocrystals are of particular interest, where electrons and holes can be confined spatially, promoting radiative recombination. However, nanocrystalline films based on traditional colloidal nanocrystal synthesis strategies suffer from the use of long insulating ligands, low colloidal nanocrystal concentration, and significant aggregation during film formation...
March 23, 2017: ACS Nano
https://www.readbyqxmd.com/read/28331187/cross-beta-nanostructures-based-on-dinaphthylalanine-gd-conjugates-loaded-with-doxorubicin
#4
Carlo Diaferia, Eliana Gianolio, Teresa Sibillano, Flavia Anna Mercurio, Marilisa Leone, Cinzia Giannini, Nicole Balasco, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo
Very recently we proposed novel di- and tetra-phenylalanine peptides derivatized with gadolinium complexes as potentials supramolecular diagnostic agents for applications in MRI (Magnetic Resonance Imaging). It was observed that in very short FF dipeptide building blocks, the propensity to aggregate decreases significantly after modification with bulky moiety such as Gd-complexes, thus limiting their potential as CAs. We hypothesized that the replacement of the Phe side chain with more extended aromatic groups could improve the self-assembling...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28328206/ligand-induced-conformational-change-of-insulin-regulated-aminopeptidase-insights-on-catalytic-mechanism-and-active-site-plasticity
#5
Anastasia Mpakali, Emmanuel Saridakis, Karl Harlos, Yuguang Zhao, Paraskevi Kokkala, Dimitris Georgiadis, Petros Giastas, Athanasios Papakyriakou, Efstratios Stratikos
Insulin-regulated aminopeptidase (IRAP) is an enzyme with several important biological functions that is known to process a large variety of different peptidic substrates although the mechanism behind this wide specificity is not clearly understood. We describe a crystal structure of IRAP in complex with a recently developed bioactive and selective inhibitor at 2.53 Å resolution. In the presence of this inhibitor the enzyme adopts a novel conformation in which domains II and IV are juxtaposed, forming a hollow structure that excludes external solvent access to the catalytic center...
March 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28328182/coordination-polymerization-of-renewable-3-methylenecyclopentene-with-rare-earth-metal-precursors
#6
Bo Liu, Shihui Li, Meiyan Wang, Dongmei Cui
Coordination polymerization of renewable 3-methylenecyclopentene has been investigated for the first time using rare-earth metal-based precursors bearing various bulky ligands. All the prepared complexes catalyze controllable polymerization of 3-methylenecyclopentene into high molecular weight polymers, of which the NPN- and NSN-tridentate non-Cp ligated lutetium-based catalytic systems exhibited extremely high activities up to 11 520 kg/(molLu ⋅h) in a dilute toluene solution (3.2 g/100 mL) at room temperature...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28327357/the-ternary-complex-structure-of-d-mandelate-dehydrogenase-with-nadh-and-anilino-oxo-acetate
#7
Nayuta Furukawa, Akimasa Miyanaga, Masahiro Nakajima, Hayao Taguchi
Enterococcus faecium NAD-dependent d-mandelate dehydrogenase (D-ManDH) belongs to a ketopantoate reductase (KPR)-related D-2-hydroxyacid dehydrogenase family, and exhibits broad substrate specificity toward bulky hydrophobic 2-ketoacids, preferring C3-branched substrates. The ternary complex structure of D-ManDH with NADH and anilino(oxo)acetate (AOA) revealed that the substrate binding induces a shear motion of the N-terminal domain along the C-terminal domain, following the hinge motion induced by the NADH binding, and allows the bound NADH molecule to form favorable interactions with a 2-ketoacid substrate...
March 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28325018/imquant-an-image-based-fluorescence-reader-for-quantitative-lateral-flow-immunoassays
#8
Kaushik Basak Chowdhury, Jayaraj Joseph, Jayaraman Kiruthi Vasan, Mohanasankar Sivaprakasam
Fluorescence immunoassays (FIA) have strong potential in enabling rapid quantitative immunological testing at point of care. Existing state of the art instruments employ laser scanning of FIA test kits, which require the use of electromechanical systems, making the instrument bulky, heavy and less reliable in the long term. There is a growing need for an extremely compact and reliable, motion-free, automated reader for accurate quantification of immunoassays. Here, we present ImQuant, an image based FIA reader with integrated monochromatic excitation source, optical filtering and real time image capture, assisted with an intuitive graphical user interface...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322974/current-modalities-in-cancer-immunotherapy-immunomodulatory-antibodies-cars-and-vaccines
#9
REVIEW
Jason Lohmueller, Olivera J Finn
Successes of immune checkpoint inhibitors (ICIs) and chimeric antigen receptor (CAR) T cell therapy in curing patients with otherwise lethal cancers have validated immunotherapy as a treatment for cancer and have inspired excitement for its broader potential. Most promising is the ability of each approach to eliminate bulky and advanced-stage cancers and to achieve durable cures. Despite this success, to date only a subset of cancer patients and a limited number of cancer types respond to these therapies. A major goal now is to expand the types of cancer and number of patients who can be successfully treated...
March 16, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28322058/high-yielding-and-divergent-paradigm-for-the-synthesis-of-d2h-symmetric-octakis-substituted-pentiptycenequinones
#10
Geeta S Vadehra, Xing Jiang, Jordan J Dotson, Gong M Chu, Miguel A Garcia-Garibay
With a rigid fused polyaromatic framework and a well-defined, highly symmetric molecular geometry, pentiptycenes are appealing building blocks for a variety of materials applications. Unfortunately, their use has been limited by the lengthy syntheses of their functionalized derivatives. This communication describes a highly efficient, brief, divergent paradigm for the preparation of octakis-substituted pentiptycene derivatives that starts with the preparation of an octakis(bromo) compound, which can be used as a Pd(0)-catalyzed coupling partner with suitable organometallic compounds to install a range of groups in high yields at the peripheral 2,3,6,7,14,15,19,20 positions, including methyl, allyl, vinyl, alkynyl, aryl, heteroaryl, and even bulky 4-(triphenylmethyl)phenyl substituents...
March 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28321944/self-assembling-brush-polymers-bearing-multisaccharides
#11
Jongchan Lee, Jin Chul Kim, Hoyeol Lee, Sungjin Song, Heesoo Kim, Moonhor Ree
Three different series of brush polymers bearing glucosyl, maltosyl, or maltotriosyl moiety at the bristle end are successfully prepared by using cationic ring-opening polymerization and two sequential postmodification reactions. All brush polymers, except for the polymer containing 100 mol% maltotriosyl moiety, demonstrate the formation of multibilayer structure in films, always providing saccharide-enriched surface. These self-assembling features are remarkable, regarding the bulkiness of saccharide moieties and the kink in the bristle due to the triazole linker...
March 21, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28319898/immunodetection-of-salivary-biomarkers-by-an-optical-microfluidic-biosensor-with-polyethylenimine-modified-polythiophene-c70-organic-photodetectors
#12
Tao Dong, Nuno Miguel Matos Pires
This work reports a novel optical microfluidic biosensor with highly sensitive organic photodetectors (OPDs) for absorbance-based detection of salivary protein biomarkers at the point of care. The compact and miniaturized biosensor has comprised OPDs made of polythiophene-C70 bulk heterojunction for the photoactive layer; whilst a calcium-free cathode interfacial layer, made of linear polyethylenimine, was incorporated to the photodetectors to enhance the low cost. The OPDs realized onto a glass chip were aligned to antibody-functionalized chambers of a poly(methyl methacrylate) microfluidic chip, in where immunogold-silver assays were conducted...
March 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28319816/dna-polyplexes-with-dendritic-glycopolymer-entrapped-gold-nanoparticles
#13
Jens Rumschöttel, Sabine Kosmella, Claudia Prietzel, Dietmar Appelhans, Joachim Koetz
Polyplexes, composed of Salmon DNA and very small gold nanoparticles embedded into a dendritic glycopolymer architecture of sugar-modified poly(ethyleneimine) (PEI-Mal) with a molar mass of about 25,000g/mol, were characterized by dynamic light scattering (DLS), zeta potential measurements, micro differential scanning calorimetry (μ-DSC) and transmission electron microscopy (TEM). The PEI-Mal-entrapped gold nanoparticles of about 2nm in diameter influence the polyplex formation of the hyperbranched PEI containing bulky maltose, and in consequence the DNA is more compactized in the inner part of spherical polyplex particles of about 150nm in diameter...
March 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28319034/sc-co-sub-2-sub-assisted-process-for-high-energy-density-aerogel-supercapacitor-the-effect-of-go-loading
#14
Maria Sarno, Lucia Baldino, Carmela Scudieri, Stefano Cardea, Paolo Ciambelli, Ernesto Reverchon
Energy density, safety, simple and environmentally friendly preparation methods are very significant aspects in the realization of a compact supercapacitor. Herein we report the use of a supercritical CO2 assisted gel drying process (SC-CO2) for the preparation of porous electrodes containing dispersed graphene in a Poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) binder membrane to sandwich in a new portable supercapacitor based on graphene oxide (GO). A GO loading of 60 wt.% has been found to give the better combination of factors (porosity, wettability, mechanical and electrochemical properties,...
March 20, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28318887/multi-focus-beamforming-for-thermal-strain-imaging-using-a-single-ultrasound-linear-array-transducer
#15
Man M Nguyen, Xuan Ding, Steven A Leers, Kang Kim
Ultrasound-induced thermal strain imaging (TSI) has been used successfully to identify lipid- and water-based tissues in atherosclerotic plaques in some research settings. However, TSI faces several challenges to be realized in clinics. These challenges include motion artifacts and displacement tracking accuracy, as well as limited heating capability, which contributes to low thermal strain signal-to-noise ratio, and a limited field of view. Our goal was to address the challenge in heating tissue in TSI. Current TSI systems use separate heating and imaging transducers, which require physical alignment of the heating and imaging beams and result in a bulky setup that limits in vivo operation...
March 15, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28318084/twisted-aromatic-frameworks-readily-exfoliable-and-solution-processable-two-dimensional-conjugated-microporous-polymers
#16
A Belen Marco, Diego Cortizo-Lacalle, Iñigo Perez-Miqueo, Giovanni Valenti, Alessandro Boni, Jan Plas, Karol Strutyński, Steven De Feyter, Francesco Paolucci, Mario Montes, Andrei N Khlobystov, Manuel Melle-Franco, Aurelio Mateo-Alonso
Twisted two-dimensional aromatic frameworks have been prepared by overcrowding the nodes with bulky and rigid substituents. The highly distorted aromatic framework with alternating out-of-plane substituents results in diminished interlayer interactions that favor the exfoliation and dispersion of individual layers in organic media.
March 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28317962/-phsio1-5-8-10-12-as-nanoreactors-for-non-enzymatic-introduction-of-ortho-meta-or-para-hydroxyl-groups-to-aromatic-molecules
#17
Mozhgan Bahrami, Xingwen Zhang, Morteza Ehsani, Yousef Jahani, Richard M Laine
Traditional electrophilic bromination follows long established "rules": electron-withdrawing substituents cause bromination selective for meta positions, whereas electron-donating substituents favor ortho and para bromination. In contrast, in the [PhSiO1.5]8,10,12 silsesquioxanes, the cages act as bulky, electron withdrawing groups equivalent to CF3; yet bromination under mild conditions, without a catalyst, greatly favors ortho substitution. Surprisingly, ICl iodination without a catalyst favors (>90%) para substitution [p-IC6H4SiO1...
March 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28316857/progressive-pseudorheumatoid-dysplasia-or-jia
#18
Geetha Wickrematilake
Progressive pseudorheumatoid dysplasia (PPD) or spondyloepiphyseal dysplasia tarda with progressive arthropathy (SEDT-PA) is a rare arthropathy of childhood involving the axial skeleton as well as small peripheral joints. A 10-year-old boy was referred by a general practitioner with pain and deformity in the fingers of hands and limping gait. There was no joint synovitis although the finger joints were bulky on examination with mild flexion deformity. Patient had exaggerated kyphosis and lumbar lordosis with pigeon chest and restricted hip joint movements...
2017: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/28316096/biochemical-characterization-and-structural-insight-into-aliphatic-%C3%AE-amino-acid-adenylation-enzymes-idnl1-and-cmis6
#19
Jolanta Cieślak, Akimasa Miyanaga, Ryoma Takaku, Makoto Takaishi, Keita Amagai, Fumitaka Kudo, Tadashi Eguchi
Macrolactam antibiotics such as incednine and cremimycin possess an aliphatic β-amino acid as a starter unit of their polyketide chain. In the biosynthesis of incednine and cremimycin, unique stand-alone adenylation enzymes IdnL1 and CmiS6 select and activate the proper aliphatic β-amino acid as a starter unit. In this study, we describe the enzymatic characterization and the structural basis of substrate specificity of IdnL1 and CmiS6. Functional analysis revealed that IdnL1 and CmiS6 recognize 3-aminobutanoic acid and 3-aminononanoic acid, respectively...
March 18, 2017: Proteins
https://www.readbyqxmd.com/read/28306261/asymmetric-synthesis-of-the-major-metabolite-of-a-cgrp-receptor-antagonist-and-mechanism-of-epoxide-hydrogenolysis
#20
Guanglin Luo, Ling Chen, Charles M Conway, Walter Kostich, Benjamin M Johnson, Alicia Ng, John E Macor, Gene M Dubowchik
An asymmetric synthesis of the major metabolite of the CGRP recepotor antagonist BMS-846372 is presented. The variously substituted cyclohepta[b]pyridine ring system represents an under-explored ring system, and showed some unexpected chemistry. Reactivities of epoxide and ketone functional groups on cycloheptane ring were greatly controlled by a remote bulky TIPS group. The rate difference of the hydrogenolysis between two diastereomeric epoxide intermediates shed some light on the mechanism of epoxide hydrogenolysis, and further deuterium labeling studies unravelled more mechanistic details on this well known chemical transformation for the first time...
March 17, 2017: Journal of Organic Chemistry
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