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Junjie Si, Yang Liu, Zhuofei He, Hui Du, Kai Du, Dong Chen, Jing Li, Mengmeng Xu, He Tian, Haiping He, Dawei Di, Changqing Lin, Yingchun Cheng, Jianpu Wang, Yizheng Jin
We report a facile solution-based approach to the in-situ growth of perovskite films consisting of monolayers of CsPbBr3 nanoplates passivated by bulky phenylbutylammonium (PBA) cations, i.e. two-dimensional layered PBA2(CsPbBr3)n-1PbBr4 perovskites. Optimizing film-formation processes leads to layered perovskites with controlled n values in the range of 12-16. The layered perovskite emitters show quantum-confined bandgap energies with a narrow distribution, suggesting the formation of thickness-controlled quantum-well (TCQW) structures...
October 18, 2017: ACS Nano
Simon J Higgins, Ali Khalid Ismael, Kun Wang, Andrea Vezzoli, Mohsin K Al-Khaykanee, Harry E Gallagher, Iain M Grace, Colin J Lambert, Bingqian Xu, Richard J Nichols
A key target in molecular electronics has been molecules having switchable electrical properties. Switching between two electrical states has been demonstrated using such stimuli as light, electrochemical voltage, complexation and mechanical modulation. A classic example of the latter is the switching of 4,4'-bipyridine, leading to conductance modulation of ~1 order of magnitude. Here, we describe the use of side-group chemistry to control the properties of a single-molecule electromechanical switch, which can be cycled between two conductance states by repeated compression and elongation...
October 17, 2017: Angewandte Chemie
Maria Maddalena Laterza, Luca Pompella, Angelica Petrillo, Giuseppe Tirino, Annalisa Pappalardo, Michele Orditura, Teresa Troiani, Fortunato Ciardiello, Natale Di Martino, Ferdinando De Vita
The best choice of chemotherapy regimen for patients with metastatic gastric cancer is still debated. Although several studies support a superior efficacy of a triplet chemotherapy regimen over a doublet-based regimen, the magnitude of this benefit appears small and accompanied by an increased toxicity. Based on this background, we evaluated the outcome of patients with HER2-negative metastatic gastric cancer (mGC) who received in the clinical practice a triplet or doublet regimen as first-line therapy. A total of 165 patients (pts) with HER2-negative mGC treated outside of clinical trials at our department with FOLFOX-4 or ECX from 2012 and 2015 were included in our retrospective analysis: FOLFOX-4: 86 pts; ECX: 79 pts...
October 17, 2017: Medical Oncology
Zhigang Wu, Yunpeng Liu, Lei Li, Xiu-Feng Wan, He Zhu, Yuxi Guo, Mohui Wei, Wanyi Guan, Peng George Wang
N-Glycans are normally involved in crucial physiological and disease processes by interactions with glycan-binding proteins. So far structurally defined N-glycans have been good candidates for glycan binding study. Herein, a class of homogeneous asymmetric N-glycans was synthesized by coupling glycan-oxazoline and N-glycans using EndoM N175Q catalyzed quick glycan extension. Branch-biased binding and spacial inhibition caused by the bulky group on the other branch of N-glycan were observed in glycan protein interactions involving lectins and these glycans by glycan microarray study...
October 18, 2017: Organic & Biomolecular Chemistry
Xiangdong Cai, Zhao Liu, Sha Zhao, Chen Song, Shouliang Dong, Jianxi Xiao
We herein report the construction of a novel single stranded fluorescent collagen mimetic peptide by introducing a bulky FAM dye in the central region rather than the N terminus. Without the need for any prior thermal or ultraviolet treatment, the peptide probe can be conveniently applied to specifically target collagen in connective tissues for fluorescence imaging.
October 18, 2017: Chemical Communications: Chem Comm
Olga Rechkoblit, Alexander Kolbanovskiy, Hannah Landes, Nicholas E Geacintov, Aneel K Aggarwal
Benzo[a]pyrene (BP) is a carcinogen in cigarette smoke which, after metabolic activation, can react with the exocyclic N (2) amino group of guanine to generate four stereoisomeric BP-N (2)-dG adducts. Rev1 is unique among translesion synthesis DNA polymerases in employing a protein-template-directed mechanism of DNA synthesis opposite undamaged and damaged guanine. Here we report high-resolution structures of yeast Rev1 with three BP-N (2)-dG adducts, namely the 10S (+)-trans-BP-N (2)-dG, 10R (+)-cis-BP-N (2)-dG, and 10S ( - )-cis-BP-N (2)-dG...
October 17, 2017: Nature Communications
Rajeshwer S Sankhala, Ravi K Lokareddy, Salma Begum, Ruth A Pumroy, Richard E Gillilan, Gino Cingolani
Active nuclear import of Ran exchange factor RCC1 is mediated by importin α3. This pathway is essential to generate a gradient of RanGTP on chromatin that directs nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Here we identify the mechanisms of importin α3 selectivity for RCC1. We find this isoform binds RCC1 with one order of magnitude higher affinity than the generic importin α1, although the two isoforms share an identical NLS-binding groove. Importin α3 uses its greater conformational flexibility to wedge the RCC1 β-propeller flanking the NLS against its lateral surface, preventing steric clashes with its Armadillo-core...
October 17, 2017: Nature Communications
M H Alizadeh, B M Reinhard
The development of optical materials and devices that mimic the functionalities of conventional bulky optical components but on a much smaller footprint remains an important priority in nanophotonics. One prominent class of such optical elements are polarizers that change the polarization state of incident light. Recently, advances in plasmonic and photonic metasurfaces have given rise to different classes of subwavelength polarizers. Low efficiency and narrow band of operation remain, however, significant challenges...
September 18, 2017: Optics Express
Jiannan Gao, Chuwen Lan, Qian Zhao, Bo Li, Ji Zhou
An electrically controlled metamaterial perfect absorber (MPA) based on Mie resonance is demonstrated experimentally and modeled numerically. A ceramic dielectric cube is adhered to a specially shaped thin copper film sputtered on a quartz plate. By passing direct current (DC) through the film, the temperature of the cube can be varied, resulting in changing the cube's permittivity and shifting the absorption resonance frequency. The frequency increases on heating and the absorption is over 99% throughout the tuning range...
September 18, 2017: Optics Express
G Kabir, A T Mohd Din, B H Hameed
The pyrolysis of oil palm mesocarp fiber (OPMF) was catalyzed with a steel slag-derived zeolite (FAU-SL) in a slow-heating fixed-bed reactor at 450 °C, 550 °C, and 600 °C. The catalytic pyrolysis of OPMF produced a maximum yield of 47 wt% bio-oil at 550 °C, and the crude pyrolysis vapor (CPV) of this process yielded crude pyrolysis oil with broad distribution of bulky oxygenated organic compounds. The bio-oil composition produced at 550 °C contained mainly light and stable acid-rich carbonyls at a relative abundance of 48...
September 28, 2017: Bioresource Technology
Mani Akhtari, Sarah A Milgrom, Chelsea C Pinnix, Jay P Reddy, Wenli Dong, Grace L Smith, Osama Mawlawi, Zeinab Abou Yehia, Jillian Gunther, Eleanor M Osborne, Therese Y Andraos, Christine F Wogan, Eric Rohren, Naveen Garg, Hubert Chuang, Joseph D Khoury, Yasuhiro Oki, Michelle Fanale, Bouthaina S Dabaja
The presence of bulky disease in Hodgkin lymphoma (HL), traditionally defined with a 1-dimensional measurement, can change a patient's risk grouping and thus the treatment approach. We hypothesized that 3-dimensional measurements of disease burden obtained from baseline (18)F-fluorodeoxyglucose positron emission tomography-computed tomography (PET-CT) scans, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), would more accurately risk stratify patients. To test this hypothesis, we reviewed pretreatment PET-CT scans of patients with stage I-II HL treated at our institution between 2003-2013...
October 16, 2017: Blood
Jaeok Park, Dmitry Rodionov, Joris W De Schutter, Yih-Shyan Lin, Youla S Tsantrizos, Albert M Berghuis
Human farnesyl pyrophosphate synthase (hFPPS) catalyzes the production of the 15-carbon isoprenoid farnesyl pyrophosphate. The enzyme is a key regulator of the mevalonate pathway and a well-established drug target. Notably, it was elucidated as the molecular target of nitrogen-containing bisphosphonates, a class of drugs that have been widely successful against bone resorption disorders. More recently, research has focused on the anticancer effects of these inhibitors. In order to achieve increased non-skeletal tissue exposure, we created phenylaminopyridine bisphosphonates (PNP-BPs) that have bulky hydrophobic side chains through a structure-based approach...
2017: PloS One
B Lallemant, S Moriniere, P Ceruse, M Lebalch, K Aubry, S Hans, G Dolivet, O Malard, Q Bonduelle, S Vergez
Posterior pharyngeal wall squamous cell carcinomas (SCCs) are rare and have an associated poor prognosis. Progress in transoral resection techniques, in particular, transoral robotic surgery (TORS), have renewed the role of surgery in their treatment. This article presents the oncological and functional results obtained by the French Group of Head and Neck Robotic Surgery for TORS for posterior pharyngeal wall SCC-curative surgery. This retrospective, multicentre study presents data collected between September 2009 and November 2013 for patients treated with TORS for posterior pharyngeal wall SCCs...
October 14, 2017: European Archives of Oto-rhino-laryngology
Keiko Sasaki, Kenta Toshiyuki, Binglin Guo, Keiko Ideta, Yoshikazu Hayashi, Tsuyoshi Hirajima, Jin Miyawaki
Discharge from accidental nuclear power plants includes boric acid, which is used as a neutron absorbent in nuclear reactors. Co-precipitation of borate with hydroxyapatite (HAp), using Ca(OH)2, is known to be an effectively fast method for stabilization of borate as well as coexisting radioactive nuclides. To reduce bulky volume of solid residues after co-precipitation, calcination is necessary to investigate the chemical stability of targets. Calcination at 850°C resulted in the high crystalization of HAp with formation of xCaO·B2O3 as a by-phase in which x increased with a decrease in the borate contents...
October 8, 2017: Journal of Hazardous Materials
Chaoyang Ti, Minh-Tri Ho-Thanh, Qi Wen, Yuxiang Liu
Position detection with high accuracy is crucial for force calibration of optical trapping systems. Most existing position detection methods require high-numerical-aperture objective lenses, which are bulky, expensive, and difficult to miniaturize. Here, we report an affordable objective-lens-free, fiber-based position detection scheme with 2 nm spatial resolution and 150 MHz bandwidth. This fiber based detection mechanism enables simultaneous trapping and force measurements in a compact fiber optical tweezers system...
October 13, 2017: Scientific Reports
Casey Ward, Maciej Maselko, Christopher Lupfer, Meagan Prescott, Manoj K Pastey
Human Respiratory Syncytial Virus (HRSV) is a leading cause of bronchopneumonia in infants and the elderly. To date, knowledge of viral and host protein interactions within HRSV is limited and are critical areas of research. Here, we show that HRSV Matrix (M) protein interacts with the cellular adaptor protein complex 3 specifically via its medium subunit (AP-3Mu3A). This novel protein-protein interaction was first detected via yeast-two hybrid screen and was further confirmed in a mammalian system by immunofluorescence colocalization and co-immunoprecipitation...
2017: PloS One
Yujia Wang, Chengwei Sun, Qihuang Gong, Jianjun Chen
By drawing an analogy with the conventional photonic crystals, the plasmonic bandgaps have mainly employed the periodic metallic structures, named as plasmonic crystals. However, the sizes of the plasmonic crystals are much larger than the wavelengths, and the large sizes considerably decrease the density of the photonic integration circuits. Here, based on the coupled-resonator effect, the plasmonic bandgaps are experimentally realized in the subwavelength waveguide-resonator structure, which considerably decreases the structure size to subwavelength scales...
October 15, 2017: Optics Letters
Dennis D Fernandes, Jasbir Bamrah, Senthilkumar Kailasam, Gregory-Neal W Gomes, Yuchong Li, Hans-Joachim Wieden, Claudiu C Gradinaru
In recent years, new labelling strategies have been developed that involve the genetic insertion of small amino-acid sequences for specific attachment of small organic fluorophores. Here, we focus on the tetracysteine FCM motif (FLNCCPGCCMEP), which binds to fluorescein arsenical hairpin (FlAsH), and the ybbR motif (TVLDSLEFIASKLA) which binds fluorophores conjugated to Coenzyme A (CoA) via a phosphoryl transfer reaction. We designed a peptide containing both motifs for orthogonal labelling with FlAsH and Alexa647 (AF647)...
October 12, 2017: Scientific Reports
Haipeng Wei, Yulan Liu, Tullimilli Y Gopalakrishna, Hoa Phan, Xiaobo Huang, Lipiao Bao, Jing Guo, Jun Zhou, Shenglian Luo, Jishan Wu, Zebing Zeng
Despite the great potential of heteroatom-contained polycyclic aromatic hydrocarbons in organic optoelectronics, there are very limited reports on hetero-aromatics containing B-N-B bond in the π-scaffold. Herein, stable 1,9-dibora-9a-azaphenalenyl (DBAP) derivatives, named as BNB-embedded phenalenyls, are presented. The DBAP skeleton contains a three-center two-π-electron B-N-B moiety with total 12 π-electrons and can be regarded as the isoelectronic structure of phenalenyl cation. Chemical reduction of the phenyl derivative of DBAP by potassium generated the dianion containing 14 delocalized π-electrons, which can be regarded as isoelectronic structure of phenalenyl anion...
October 13, 2017: Journal of the American Chemical Society
Mario Turri-Zanoni, Paolo Battaglia, Paolo Castelnuovo
Cystic lesions involving the tongue base are rare, generally presenting in pediatric patients, and they may encompass different pathologies such as ranula, lingual ectopic thyroid, thyroglossal duct cyst (TDC), dysontogenetic cysts, benign, and malignant tumors.This paper describes the case of a 19-year-old girl with phonation impairment and mild dysphagia due to limited tongue protrusion and movements. Radiologic examinations revealed a bulky cystic lesion at the base of tongue with displacement of extrinsic lingual muscles...
October 11, 2017: Journal of Craniofacial Surgery
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