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https://www.readbyqxmd.com/read/28821849/the-preparation-and-application-of-a-graphene-based-hybrid-flame-retardant-containing-a-long-chain-phosphaphenanthrene
#1
Wenhua Chen, Yuansen Liu, Pengju Liu, Changan Xu, Yuan Liu, Qi Wang
A novel hybrid flame retardant combining graphene oxide (GO) with long-chain phosphaphenanthrene was fabricated via surface grafting reaction. Taking advantageous of the double barrier effects, including the physical shield contributed by graphene nanoplates during the initial stage and the chemical char contributed by phosphaphenanthrene during the later stage, greatly decreased the release rate of decomposed volatiles from the resin, as well as minimized the release of oxygen and combustion heat. Hence, such hybrid flame retardant can overcome the shortcomings of early acid catalyzed degradation effects caused by conventional flame retardants containing phosphorus...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821844/n-glycosylation-triggers-a-dual-selection-pressure-in-eukaryotic-secretory-proteins
#2
Máximo Lopez Medus, Gabriela E Gomez, Lucía F Zacchi, Paula M Couto, Carlos A Labriola, María S Labanda, Rodrigo Corti Bielsa, Eugenia M Clérico, Benjamin L Schulz, Julio J Caramelo
Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum. N-glycans fulfill multiple structural and biological functions, and are crucial for productive folding of many glycoproteins. N-glycosylation involves the attachment of an oligosaccharide to selected asparagine residues in the sequence N-X-S/T (X ≠ P), a motif known as an N-glycosylation'sequon'. Mutations that create novel sequons can cause disease due to the destabilizing effect of a bulky N-glycan...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821638/fluorescent-probes-for-selective-protein-labeling-in-lysosomes-a-case-of-%C3%AE-galactosidase-a
#3
Cornelius Bohl, Adam Pomorski, Susanne Seemann, Anne-Marie Knospe, Chaonan Zheng, Artur Krężel, Arndt Rolfs, Jan Lukas
Fluorescence-based live-cell imaging (LCI) of lysosomal glycosidases is often hampered by unfavorable pH and redox conditions that reduce fluorescence output. Moreover, most lysosomal glycosidases are low-mass soluble proteins that do not allow for bulky fluorescent protein fusions. We selected α-galactosidase A (GALA) as a model lysosomal glycosidase involved in Anderson-Fabry disease (AFD) for the current LCI approach. Examination of the subcellular localization of AFD-causing mutants can reveal the mechanism underlying cellular trafficking deficits...
August 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28816170/role-of-consolidative-radiation-therapy-after-autologous-hematopoietic-cell-transplantation-for-the-treatment-of-relapsed-or-refractory-hodgkin-lymphoma
#4
Christopher Wilke, Qing Cao, Kathryn E Dusenbery, Veronika Bachanova, Aleksandr Lazaryan, Chung K Lee, Jianling Yuan
PURPOSE: To evaluate the role of the addition of consolidative radiation therapy after high-dose chemotherapy and autologous hematopoietic cell transplantation (AHCT) for relapsed or refractory Hodgkin lymphoma (HL). METHODS AND MATERIALS: Medical records were reviewed from a total of 80 consecutive patients who underwent high-dose chemotherapy with AHCT treated under a single protocol at University of Minnesota between November 2005 and January 2014. Of these, 32 patients received radiation therapy after AHCT as planned consolidation...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28815231/fluorescence-activated-cell-sorting-via-a-focused-traveling-surface-acoustic-beam
#5
Zhichao Ma, Yinning Zhou, David J Collins, Ye Ai
Fluorescence activated cell sorting (FACS) has become an essential technique widely exploited in biological studies and clinical applications. However, current FACS systems are quite complex, expensive, bulky, and pose potential sample contamination and biosafety issues due to the generation of aerosols in an open environment. Microfluidic technology capable of precise cell manipulation has great potential to reinvent and miniaturize conventional FACS systems. In this work, we demonstrate a benchtop scale FACS system that makes use of a highly focused traveling surface acoustic wave beam to sort out micron-sized particles and biological cells upon fluorescence interrogation at ∼kHz rates...
August 17, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28813880/series-elastic-actuation-of-an-elbow-rehabilitation-exoskeleton-with-axis-misalignment-adaptation
#6
Kuan-Yi Wu, Yin-Yu Su, Ying-Lung Yu, Kuei-You Lin, Chao-Chieh Lan
Powered exoskeletons can facilitate rehabilitation of patients with upper limb disabilities. Designs using rotary motors usually result in bulky exoskeletons to reduce the problem of moving inertia. This paper presents a new linearly actuated elbow exoskeleton that consists of a slider crank mechanism and a linear motor. The linear motor is placed beside the upper arm and closer to shoulder joint. Thus better inertia properties can be achieved while lightweight and compactness are maintained. A passive joint is introduced to compensate for the exoskeleton-elbow misalignment and intersubject size variation...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28812092/effect-of-ligand-structure-on-the-size-control-of-mono-and-bi-thiolate-protected-silver-nanoclusters
#7
Kaiyuan Zheng, Xun Yuan, Jianping Xie
Ligand structure could control the size and structure of thiolate-protected silver nanoclusters (Ag NCs) in water. Small alkane-thiols, medium-sized aromatic-thiols, and bulky thiol-containing tri-peptides direct the formation of Ag25(SR)18, Ag44(SR)30, and Ag9-15(SR)5-10, respectively. In addition, small alkane-thiol collocates well with other types of thiolate ligand to generate bi-thiolate-protected Ag25 NCs with controlled ligand landscapes on their surfaces.
August 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28810663/different-properties-of-polysialic-acids-synthesized-by-the-polysialyltransferases-st8sia2-and-st8sia4
#8
Airi Mori, Masaya Hane, Yuki Niimi, Ken Kitajima, Chihiro Sato
Polysialic acid (polySia) is mainly found as a modification of neural cell adhesion molecule (NCAM) in whole embryonic brains, as well as restricted areas of adult vertebrate brains, including the hippocampus. PolySia shows not only repulsive effects on NCAM-involved cell-cell interactions due to its bulky and hydrated properties, but also attractive effects on the interaction with neurologically active molecules, which exerts a reservoir function. Two different polysialyltransferases, ST8SIA2 and ST8SIA4, are involved in the synthesis of polySia chains; however, to date, the differences of the properties between polySia chains synthesized by these two enzymes remain unknown...
September 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28810119/conformational-flexibility-of-the-benzyl-guanine-adduct-in-a-bypass-polymerase-active-site-permits-replication-insights-from-molecular-dynamics-simulations
#9
Katie A Wilson, Stacey D Wetmore
Although translesion synthesis (TLS) polymerases play key roles in replicating DNA that contains nucleobase addition products (adducts), there are many unknowns about their function. The present work gains indispensable structural insights from molecular dynamics simulations on the replication of O6-benzyl-guanine (Bz-dG) prior to bond formation during dCTP insertion opposite the adduct by Dpo4. When combined with previous X-ray crystal structures of the Bz-dG extension complex, molecular details are now available for each stage during a single TLS replication cycle for this carcinogenic lesion...
August 15, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28809470/chelation-controlled-additions-to-chiral-%C3%AE-and-%C3%AE-silyloxy-%C3%AE-halo-and-%C3%AE-vinyl-carbonyl-compounds
#10
Xinyuan Fan, Patrick J Walsh
The science and art of preventing and managing disease and prolonging life is dependent on advances in medicine, biology, and biochemistry. Many of these advances will involve interactions of small molecules with biological entities. As such, they will rely on the efficient synthesis of active compounds with very high stereochemical purity. Although enantioselective reactions are important in this regard, most stereocenters in complex molecule synthesis are installed in diastereoselective reactions. Perhaps the most well-known diastereoselective C-C bond-forming reaction is the addition of nucleophiles to carbonyl groups with α- or β-stereogenic centers...
August 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28807809/paraureteral-endometriosis-with-bilateral-gross-hydroureters-and-left-renal-compromise
#11
Arnaud Wattiez, Razan Nasir
Deep endometriosis is usually defined as endometriosis infiltrating the peritoneum by >5 mm. It sometimes involves the ureter causing hydronephrosis in 5% of cases. The latter is associated with 18% ureteral lesions. Ureteral endometriosis is one of the rare causes of silent Kidney failure. The ureter obstruction can lead to urinary tract obstruction, hydronephrosis and hydroureters. The ureters are usually compressed externally by the endometriotic lesions surrounding it causing extrinsic ureteral endometriosis, and sometimes by pressure from the bulky adenomyotic uterus with paraureteral fibrosis...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28805882/plant-array-chip-for-the-germination-and-growth-screening-of-arabidopsis-thaliana
#12
Youn-Hee Park, Nayoung Lee, Giltsu Choi, Je-Kyun Park
A screening process for the germination and growth of seed is generally required for plant research. Such a repetitive screening process is costly and time-consuming, and its bulky setup requires a lot of space. In particular, the control of the variables, such as light, nutrients, hormones and temperature, is difficult due to the limited space for incubation. In addition, small seeds such as Arabidopsis thaliana are difficult to handle as they are hundreds of microns in diameter and require a more precisely controllable screening environment...
August 14, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28801323/transvaginal-postpartum-manual-removal-of-a-prolapsed-submucous-leiomyoma-initially-diagnosed-hybrid-predominantly-intramural
#13
Wael Elgonaid, Reem Belkhir, Vincent Boama
We present a rare case of a large infarcted submucous fibroid removed manually after a normal vaginal delivery. This patient was known to have a large postero-fundal hybrid predominantly intramural uterine fibroid, measuring 11 x 10 cm in diameter and diagnosed 2 years prior to last conception. Thirty-five days postpartum, she presented with severe lower abdominal pain and foul smell per vaginum. Abdominal examination revealed a very tender bulky uterus at 24 weeks size, and vaginal examination revealed a big fleshy smelly mass with friable surface just bulging from a dilated cervix...
August 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28800189/supramolecular-host-guest-inclusion-for-distinguishing-cucurbit-7-uril-based-pseudorotaxanes-from-small-molecule-ligands-in-coordination-assembly-with-uranyl-center
#14
Wei-Qun Shi, Lei Mei, Zhen-Ni Xie, Kong-Qiu Hu, Li-Yong Yuan, Zeng-Qiang Gao, Zhi-Fang Chai
Although the capability of supramolecular pseudorotaxane/rotaxane systems as ligands for coordination with actinides has been identified by the on-going emerging of uranyl-organic polyrotaxane compounds, it is, however, still unknown how supramolecular inclusion affects the coordination assembly of the simple 'axle' ligand with uranyl species. Herein, a semi-rigid organic dicarboxylate compound [BzBPCEt]Br2 (L1) is selected as a small-molecule 'axle' ligand and the corresponding cucurbit[7]uril (CB7)-based [2]pseudorotaxane ligand, [BzBPCEt]Br2@CB7 (L1@CB7) has been also synthesized through CB7-based inclusion in this work...
August 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28796348/anion-%C3%AF-catalysts-with-axial-chirality
#15
Chao Wang, Stefan Matile
The idea of anion-π catalysis is to stabilize anionic transition states by anion-π interactions on aromatic surfaces. For asymmetric anion-π catalysis, π-acidic surfaces have been surrounded with stereogenic centers. This manuscript introduces the first anion-π catalysts that operate with axial chirality. Bifunctional catalysts with tertiary amine bases next to π-acidic naphthalenediimide planes are equipped with a bulky aromatic substituent in the imide position to produce separable atropisomers. The addition of malonic acid half thioesters to enolate acceptors is used for evaluation...
August 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28795747/silver-complexes-stabilized-by-large-silanethiolate-ligands-crystal-structures-and-luminescence-properties
#16
Anna Ciborska, Zbigniew Hnatejko, Katarzyna Kazimierczuk, Agnieszka Mielcarek, Aleksandra Wiśniewska, Anna Dołęga
Bulky silanethiolate and disiladithiolate ligands were applied to synthesize one mononuclear and three trinuclear silver complexes including two cyclic "microclusters" and a linear tri-nuclear silanethiolate complex. All obtained compounds are characterized by X-ray diffraction and FT-IR. NMR and emission spectroscopies were used where possible. The first trinuclear anionic silver thiolate is structurally characterized. The influence of the different charge of cyclic silver complexes as well as the overall ligand environment on the structural properties is demonstrated...
August 10, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28795707/stoichiometric-and-catalytic-isomerization-of-alkenylboranes-using-bulky-lewis-bases
#17
Fu An Tsao, Anson Sathaseevan, Hui Zhu, Stefan Grimme, Gerhard Erker, Douglas W Stephan
1,1-Carboboration of alkynes with boranes R'B(C6F5)2 (R' = (CH2)3Ph, C6F5) affords mixtures of the E and Z isomers of RCH = CR'B(C6F5)2 (R = (CH2)2Me, (CH2)3Me, (CH2)2Ph, CH2CHMe2, CHMe2, CMe3, CH2OMe, CH2N(CO)2C6H4), treatment of these alkenylboranes with stoichiometric or catalytic amounts of tBu2PH or other donors are shown to induce isomerization. The proposed mechanism involving a zwitterionic borataalkene intermediate is supported by computations.
August 10, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28795372/development-of-a-pharmacophore-for-cruzain-using-oxadiazoles-as-virtual-molecular-probes-quantitative-structure-activity-relationship-studies
#18
Anacleto S de Souza, Marcelo T de Oliveira, Adriano D Andricopulo
Chagas's is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. According to the World Health Organization, 7 million people are infected worldwide leading to 7000 deaths per year. Drugs available, nifurtimox and benzimidazole, are limited due to low efficacy and high toxicity. As a validated target, cruzain represents a major front in drug discovery attempts for Chagas disease. Herein, we describe the development of 2D QSAR ([Formula: see text] = 0.81) and a 3D-QSAR-based pharmacophore ([Formula: see text] = 0...
August 9, 2017: Journal of Computer-aided Molecular Design
https://www.readbyqxmd.com/read/28793191/structural-basis-of-analog-specificity-in-pkg-i-and-ii
#19
James C Campbell, Philipp Henning, Eugen Franz, Banumathi Sankaran, Friedrich W Herberg, Choel Kim
Cyclic GMP analogs, 8-Br, 8-pCPT, and PET-cGMP, have been widely used for characterizing cellular functions of cGMP dependent protein kinase (PKG) I and II isotypes. However, interpreting results obtained using these analogs has been difficult due to their low isotype specificity. Additionally each isotype has two binding sites with different cGMP affinities and analog selectivities, making understanding the molecular basis for isotype specificity of these compounds even more challenging. To determine isotype specificity of cGMP analogs and their structural basis, we generated the full-length regulatory domains of PKG I and II isotypes with each binding site disabled, determined their affinities for these analogs, and obtain co-crystal structures of both isotypes bound with cGMP analogs...
August 9, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28792216/discrete-gef5-anion-structurally-characterized-with-a-readily-synthesized-imidazolium-based-naked-fluoride-reagent
#20
Blaž Alič, Melita Tramšek, Anton Kokalj, Gašper Tavčar
The recently prepared novel naked fluoride reagent 1,3-bis(2,6-diisopropylphenyl)imidazolium fluoride ([(L(Dipp))H][F]), treated with an excess of MF4 (M = Si, Ge), results in isolation of [(L(Dipp))H][MF5] products with the elusive trigonal bipyramidal MF5(-) anions. Specific steric characteristics of the [(L(Dipp))H](+) cation readily support isolation of monomeric and discrete trigonal bipyramidal fluorido anions of silicon and germanium. Based on combination of experimental results and DFT calculations, we demonstrate that the role of bulky cation is not solely due to steric hindering but also due to electrostatic effects, which are important in the design of such uncommon species...
August 9, 2017: Inorganic Chemistry
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