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https://www.readbyqxmd.com/read/28103392/a-peroxygenase-from-chaetomium-globosum-catalyzes-the-selective-oxygenation-of-testosterone
#1
Jan Kiebist, Kai-Uwe Schmidtke, Jörg Zimmermann, Harald Kellner, Nico Jehmlich, René Ullrich, Daniel Zänder, Martin Hofrichter, Katrin Scheibner
Unspecific peroxygenases (UPO, EC 1.11.2.1) secreted by fungi open an efficient way to selectively oxyfunctionalize diverse organic substrates including less activated hydrocarbons by transferring peroxide-borne oxygen. Herein, we investigated a cell-free approach to incorporate epoxy and hydroxyl functionalities directly into the bulky molecule of testosterone by a novel unspecific peroxygenase that was produced by the ascomycetous fungus Chaetomium globosum in a complex medium rich in carbon and nitrogen...
January 19, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28101405/deep-tissue-photoacoustic-computed-tomography-with-a-fast-and-compact-laser-system
#2
Depeng Wang, Yuehang Wang, Weiran Wang, Dandan Luo, Upendra Chitgupi, Jumin Geng, Yang Zhou, Lidai Wang, Jonathan F Lovell, Jun Xia
Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 - 200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diode-pumped laser used in this study had a miniature footprint (13 × 14 × 7 cm(3)), weighed only 1...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28099616/do-you-know-this-syndrome-type-2-benign-symmetric-lipomatosis-launois-bensaude
#3
Ana Cláudia Cavalcante Esposito, Tania Munhoz, Luciana Patrícia Fernandes Abbade, Hélio Amante Miot
A 57-year-old female showed bulky, loose tumors, which progressively spread to her arms, anterior chest, and back. She reported dysphagia and dyspnea after mild exertion. She denied alcohol consumption. CT scan of her chest showed no internal lesions. Benign symmetric lipomatosis is a rare syndrome, clinically described as multiple nonencapsulated lipomas of various sizes and symmetrical distribution. This syndrome has three known phenotypes; in type 2 (Launois-Bensaude syndrome), lesions occur primarily on the shoulders, upper arms, and chest, and is unrelated to alcoholism...
November 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28098841/compressed-sensing-techniques-applied-to-ultrasonic-imaging-of-cargo-containers
#4
Yuri Álvarez López, José Ángel Martínez Lorenzo
One of the key issues in the fight against the smuggling of goods has been the development of scanners for cargo inspection. X-ray-based radiographic system scanners are the most developed sensing modality. However, they are costly and use bulky sources that emit hazardous, ionizing radiation. Aiming to improve the probability of threat detection, an ultrasonic-based technique, capable of detecting the footprint of metallic containers or compartments concealed within the metallic structure of the inspected cargo, has been proposed...
January 15, 2017: Sensors
https://www.readbyqxmd.com/read/28098461/readily-accessible-unsymmetrical-unsaturated-2-6-diisopropylphenyl-n-heterocyclic-carbene-ligands-applications-in-enantioselective-catalysis
#5
Robert Tarrieu, Adrien Dumas, Jompol Thongpaen, Thomas Vives, Thierry Roisnel, Vincent Dorcet, Christophe Crévisy, Olivier Baslé, Marc Mauduit
A new multicomponent procedure was applied to the synthesis of (a)chiral bulky unsymmetrical unsaturated 2,6-diisopropylphenyl-N-heterocyclic carbene (NHC) precursors with excellent selectivity (up to 95%) and good yields. This approach offers access to new chiral NHCs ligands, which found successful applications in both copper-catalyzed asymmetric allylic alkylation and copper-catalyzed asymmetric borylation.
January 18, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28097796/reductive-dehydrogenation-of-a-stannane-via-multiple-sn-h-activation-by-frustrated-lewis-pairs
#6
Christian P Sindlinger, Frederik S W Aicher, Hartmut Schubert, Lars Wesemann
A bulky substituted stannane Ar*SnH3 (Ar*=2,6-(2',4',6'-triisopropylphenyl)phenyl) was treated with the well-known frustrated Lewis pair (FLP) PtBu3 /B(C6 F5 )3 in varying stoichiometries. To some degree, hydride abstraction and adduct formation is observed, leading to [Ar*SnH2 (PtBu3 )](+) which is rather unreactive toward further dehydrogenation. In a competing process, the FLP proved to be capable of completely striping-off hydrogen and hydrides to generate the first cationic phosphonio-stannylene [Ar*Sn(PtBu3 )](+) ...
January 18, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28093469/assembly-of-the%C3%A2-elongated-collagen-prolyl-4-hydroxylase-%C3%AE-2%C3%AE-2-heterotetramer%C3%A2-around-a-central-%C3%AE-2-dimer
#7
Kristian Koski, Jothi Anantharajan, Petri Kursula, Prathusha Dhavala, Abhinandan Venkatesha Murthy, Ulrich Bergmann, Johanna Myllyharju, Rik K Wierenga
COLLAGEN PROLYL 4-HYDROXYLASE C-P4H, AN Α2Β2 HETEROTETRAMER, IS A CRUCIAL ENZYME FOR COLLAGEN SYNTHESIS THE Α SUBUNIT CONSISTS OF AN N TERMINAL DIMERIZATION DOMAIN, A CENTRAL PEPTIDE-SUBSTRATE-BINDING PSB DOMAIN, AND A C TERMINAL CATALYTIC CAT DOMAIN THE Β SUBUNIT ALSO KNOWN AS PROTEIN DISULFIDE ISOMERASE PDI ACTS AS A CHAPERONE, STABILIZING THE FUNCTIONAL CONFORMATION OF C-P4H C-P4H HAS BEEN STUDIED FOR DECADES, BUT ITS STRUCTURE HAS REMAINED ELUSIVE HERE, WE PRESENT : A THREE-DIMENSIONAL SMALL-ANGLE X-RAY SCATTERING SAXS MODEL OF THE ENTIRE HUMAN C-P4H-I HETEROTETRAMER C-P4H IS AN ELONGATED, BILOBAL, SYMMETRIC MOLECULE WITH A LENGTH OF 290 Å THE DIMERIZATION DOMAINS FROM THE TWO A SUBUNITS FORM A PROTEIN-PROTEIN DIMER INTERFACE, ASSEMBLED AROUND THE CENTRAL ANTIPARALLEL COILED-COIL INTERFACE OF THEIR N TERMINAL Α HELICES THIS REGION FORMS A THIN WAIST IN THE BILOBAL TETRAMER THE TWO PSB/CAT UNITS, EACH COMPLEXED WITH A PDI/Β SUBUNIT, FORM TWO BULKY LOBES POINTING OUTWARD FROM THIS WAIST REGION, SUCH THAT THE PDI/Β SUBUNITS LOCATE AT THE FAR ENDS OF THE ΒΑΑΒ COMPLEX THE PDI/Β SUBUNIT INTERACTS EXTENSIVELY WITH THE CAT DOMAIN THE ASYMMETRIC SHAPE OF TWO TRUNCATED C-P4H-I VARIANTS, ALSO CHARACTERIZED IN THIS STUDY, AGREES WITH THIS ASSEMBLY FURTHERMORE, DATA FROM THESE TRUNCATED VARIANTS SHOW THAT DIMERIZATION BETWEEN THE A SUBUNITS HAS AN IMPORTANT ROLE IN ACHIEVING THE CORRECT PSB-CAT ASSEMBLY COMPETENT FOR CATALYTIC ACTIVITY KINETIC ASSAYS WITH VARIOUS PROLINE-RICH PEPTIDE SUBSTRATES AND INHIBITORS SUGGEST THAT IN THE COMPETENT ASSEMBLY, THE PSB DOMAIN BINDS TO THE PROCOLLAGEN SUBSTRATE DOWNSTREAM FROM THE CAT DOMAIN...
January 16, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28092946/carcinogenesis-of-the-oral-cavity-environmental-causes-and-potential-prevention-by-black-raspberry
#8
Karam El-Bayoumy, Kun-Ming Chen, Shang-Min Zhang, Yuan-Wan Sun, Shantu Amin, Gary Stoner, Joseph B Guttenplan
Worldwide, cancers of the oral cavity and pharynx comprise the sixth most common malignancies. Histologically, more than 90% of oral cancers are squamous cell carcinoma (SCC). Epidemiologic data strongly support the role of exogenous factors such as tobacco, alcohol, and human papilloma virus infection as major causative agents. Avoidance of risk factors has only been partially successful, and survival rates have not improved despite advances in therapeutic approaches. Therefore, new or improved approaches to prevention and/or early detection are critical...
January 17, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/28089555/epstein-barr-virus-and-renal-transplantation
#9
REVIEW
Jade Le, Christine M Durand, Irfan Agha, Daniel C Brennan
Epstein-Barr virus (EBV) is a gamma herpesvirus associated with diseases ranging from asymptomatic viremia to post-transplant malignancies in kidney transplant recipients. EBV specifically is associated with post-transplantation lymphoproliferative disorder (PTLD), in kidney transplant recipients, with increased risk in EBV seronegative patients with EBV seropositive donors on intensified immunosuppression. The diagnosis of PTLD relies on clinical suspicion plus tissue biopsy with polymerase chain reaction (PCR) testing of blood currently used for risk determination in high-risk recipients...
December 29, 2016: Transplantation Reviews
https://www.readbyqxmd.com/read/28079943/cooperative-activation-of-isocyanates-by-al-n-based-active-lewis-pairs-and-the-generation-of-a-c5-chain-by-simultaneous-formation-of-two-c-c-bonds
#10
Katharina Martinewski, Thorsten Holtrichter-Rößmann, Christian Rösener, Alexander Hepp, Ernst-Ulrich Würthwein, Werner Uhl
The active Al/N Lewis pair, (Me3 C)2 Al-C(SiMe3 )=C(H)-N(CHMe-CH2 )2 CH2 (2), reacted with isocyanates to afford a fascinating variety of products. One equivalent of Ph-N=C=O yielded by the release of H-C≡C-SiMe3 an urea-type ligand which coordinated the Al atom in a chelating manner (4). Dipp-N=C=O gave a similar product, but the bulky substituent hindered the approach of the N-aryl group to Al. A situation similar to that of frustrated Lewis pairs resulted in the coordination of the alkyne to the Al and N atoms (6) by C-H bond activation...
November 7, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28079372/effect-of-water-coordination-on-luminescent-properties-of-pyrazine-bridged-dinuclear-cu-i-complexes
#11
Atsushi Kobayashi, Ryuya Arata, Tomohiro Ogawa, Masaki Yoshida, Masako Kato
Two luminescent pyrazine-bridged dinuclear Cu(I) complexes, namely, [{Cu(PPh3)2(H2O)}(μ-MeOpyz){Cu(PPh3)2(CH3CN)}](BF4)2 and [{Cu(PPh3)2(H2O)}(μ-MeOpyz){Cu(PPh3)2(H2O)}](BF4)2 (H2O-Cu2-AN and H2O-Cu2-H2O; PPh3 = triphenylphosphine, MeOpyz = 2-methoxypyrazine), were successfully synthesized and characterized by single-crystal X-ray diffraction and luminescence measurements. X-ray analysis revealed that the water molecules are coordinated to both Cu(I) ions to form almost the same P2N1O1 coordination structure in H2O-Cu2-H2O, whereas one of the two Cu ions in H2O-Cu2-AN was coordinated by acetonitrile instead of water to form a different P2N2 coordination environment...
January 12, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28077981/dna-polymerase-kappa-protects-human-cells-against-mmc-induced-genotoxicity-through-error-free-translesion-dna-synthesis
#12
Yuki Kanemaru, Tetsuya Suzuki, Akira Sassa, Kyomu Matsumoto, Noritaka Adachi, Masamitsu Honma, Satoshi Numazawa, Takehiko Nohmi
BACKGROUND: Interactions between genes and environment are critical factors for causing cancer in humans. The genotoxicity of environmental chemicals can be enhanced via the modulation of susceptible genes in host human cells. DNA polymerase kappa (Pol κ) is a specialized DNA polymerase that plays an important role in DNA damage tolerance through translesion DNA synthesis. To better understand the protective roles of Pol κ, we previously engineered two human cell lines either deficient in expression of Pol κ (KO) or expressing catalytically dead Pol κ (CD) in Nalm-6-MSH+ cells and examined cytotoxic sensitivity against various genotoxins...
2017: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/28075138/control-of-chemo-regio-and-enantioselectivity-in-copper-hydride-reductions-of-morita-baylis-hillman-adducts
#13
Roscoe T H Linstadt, Carl A Peterson, Carina I Jette, Zarko V Boskovic, Bruce H Lipshutz
Nonracemically ligated copper hydride can be used to effect tandem SN2'/1,2-reductions of racemic Morita-Baylis-Hillman (MBH) acetates to access enantioenriched chiral allylic alcohols with defined olefin geometry. MBH esters, including those with β-substitution, can be transformed to stereodefined enoates by taking advantage of a bulky, oligomeric, in situ generated trialkoxysiloxane leaving group. Finally, an atypical conversion of easily arrived at MBH alcohol derivatives to nonracemic allylic alcohols is disclosed...
January 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28073257/protein-containing-lipid-bilayers-intercalated-with-size-matched-mesoporous-silica-thin-films
#14
Simon Isaksson, Erik B Watkins, Kathryn L Browning, Tania Kjellerup Lind, Marité Cárdenas, Kristina Hedfalk, Fredrik Höök, Martin Andersson
Proteins are key components in a multitude of biological processes, of which the functions carried out by transmembrane (membrane-spanning) proteins are especially demanding for investigations. This is because this class of protein needs to be incorporated into a lipid bilayer representing its native environment, and in addition, many experimental conditions also require a solid support for stabilization and analytical purposes. The solid support substrate may, however, limit the protein functionality due to protein-material interactions and a lack of physical space...
January 11, 2017: Nano Letters
https://www.readbyqxmd.com/read/28072577/feasibility-of-tungsten-functional-paper-in-electron-grid-therapy-a-monte-carlo-study
#15
Mikoto Tamura, Hajime Monzen, Kazuki Kubo, Makoto Hirata, Yasumasa Nishimura
Electron grid therapy is expected to be a valid treatment for bulky superficial tumors. It is difficult, however, to fit irradiation fields to bulky superficial tumor shapes for conventional electron grid therapy with a cerrobend grid collimator. In this study, we investigated whether a grid collimator using tungsten functional paper (TFP), with its radiation shielding ability, could be used for electron grid therapy. Dose distributions were measured using 9 MeV electron grid beams from a cerrobend grid collimator...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28063370/enhanced-desorption-of-cs-from-clays-by-a-polymeric-cation-exchange-agent
#16
Chan Woo Park, Bo Hyun Kim, Hee-Man Yang, Bum-Kyoung Seo, Kune-Woo Lee
We report on a new approach to increase the removal of cesium from contaminated clays based on the intercalation of a cationic polyelectrolyte into the clay interlayers. A highly charged cationic polyelectrolyte, polyethyleneimine (PEI), was shown to intercalate into the negatively charged interlayers and readily replaced Cs ions adsorbed on the interlayers of montmorillonite. The polycation desorbed significantly more Cs strongly bound to the clay than did single cations. Moreover, additional NH4(+) treatment following the PEI treatment enhanced desorption of Cs ions that were less accessible by the bulky polyelectrolyte...
December 21, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28059085/hampering-effect-of-cholesterol-on-the-permeation-of-reactive-oxygen-species-through-phospholipids-bilayer-possible-explanation-for-plasma-cancer-selectivity
#17
Jonas Van der Paal, Claudia Verheyen, Erik C Neyts, Annemie Bogaerts
In recent years, the ability of cold atmospheric pressure plasmas (CAPS) to selectively induce cell death in cancer cells has been widely established. This selectivity has been assigned to the reactive oxygen and nitrogen species (RONS) created in CAPs. To provide new insights in the search for an explanation for the observed selectivity, we calculate the transfer free energy of multiple ROS across membranes containing a varying amount of cholesterol. The cholesterol fraction is investigated as a selectivity parameter because membranes of cancer cells are known to contain lower fractions of cholesterol compared to healthy cells...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28057420/structure-activity-relationships-of-benzylproline-derived-inhibitors-of-the-glutamine-transporter-asct2
#18
Kurnvir Singh, Rose Tanui, Armanda Gameiro, Gilad Eisenberg, Claire Colas, Avner Schlessinger, Christof Grewer
The glutamine transporter ASCT2 has been identified as a promising target to inhibit rapid growth of cancer cells. However, ASCT2 pharmacology is not well established. In this report, we performed a systematic structure activity analysis of a series of substituted benzylproline derivatives. Substitutions on the phenyl ring resulted in compounds with characteristics of ASCT2 inhibitors. Apparent binding affinity increased with increasing hydrophobicity of the side chain. In contrast, interaction of the ASCT2 binding site with specific positions on the phenyl ring was not observed...
December 27, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28056114/diagnosis-and-management-of-waldenstr%C3%A3-m-macroglobulinemia-mayo-stratification-of-macroglobulinemia-and-risk-adapted-therapy-msmart-guidelines-2016
#19
Prashant Kapoor, Stephen M Ansell, Rafael Fonseca, Asher Chanan-Khan, Robert A Kyle, Shaji K Kumar, Joseph R Mikhael, Thomas E Witzig, Michelle Mauermann, Angela Dispenzieri, Sikander Ailawadhi, A Keith Stewart, Martha Q Lacy, Carrie A Thompson, Francis K Buadi, David Dingli, William G Morice, Ronald S Go, Dragan Jevremovic, Taimur Sher, Rebecca L King, Esteban Braggio, Ann Novak, Vivek Roy, Rhett P Ketterling, Patricia T Greipp, Martha Grogan, Ivana N Micallef, P Leif Bergsagel, Joseph P Colgan, Nelson Leung, Wilson I Gonsalves, Yi Lin, David J Inwards, Suzanne R Hayman, Grzegorz S Nowakowski, Patrick B Johnston, Steven J Russell, Svetomir N Markovic, Steven R Zeldenrust, Yi L Hwa, John A Lust, Luis F Porrata, Thomas M Habermann, S Vincent Rajkumar, Morie A Gertz, Craig B Reeder
Importance: Waldenström macroglobulinemia (WM), an IgM-associated lymphoplasmacytic lymphoma, has witnessed several practice-altering advances in recent years. With availability of a wider array of therapies, the management strategies have become increasingly complex. Our multidisciplinary team appraised studies published or presented up to December 2015 to provide consensus recommendations for a risk-adapted approach to WM, using a grading system. Observations: Waldenström macroglobulinemia remains a rare, incurable cancer, with a heterogeneous disease course...
January 5, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28055206/exploring-ultrashort-hydrogen-hydrogen-nonbonded-contacts-in-constrained-molecular-cavities
#20
Nilangshu Mandal, Saied Md Pratik, Ayan Datta
Confined molecular chambers such as macrocycle bridged E1-H···H-E2 (E1(E2) = Si(Si), 1) exhibit rare ultrashort H···H nonbonded contacts (d(H···H) = 1.56 Å). In this article, on the basis of density functional theory and ab initio molecular dynamics simulations, we propose new molecular motifs where d(H···H) can be reduced to 1.44 Å (E1(E2) = Si(Ge), 3). Further tuning the structure of the macrocycle by replacing the bulky phenyl groups by ethylenic spacers and substitution of the H-atoms by -CN groups makes the cavity more compact and furnishes even shorter d(H···H) = 1...
January 18, 2017: Journal of Physical Chemistry. B
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