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Antonino Ditto, Giorgio Bogani, Fabio Martinelli, Mauro Signorelli, Valentina Chiappa, Cono Scaffa, Alice Indini, Umberto Leone Roberti Maggiore, Domenica Lorusso, Francesco Raspagliesi
STUDY OBJECTIVE: Growing evidence supports the safety of laparoscopic approach for patients affected by apparent early stage ovarian cancer (eEOC). However, no well-designed studies comparing laparoscopic (LS) and open surgical staging (OSS) are available. In the present investigation we aimed to provide a balanced long-term comparison between these two approaches. DESIGN: Retrospective study DESIGN CLASSIFICATION: Canadian Task Force classification II-2 SETTING: Tertiary Centre PATIENTS: Data of consecutive patients affected by eEOC who had LS were matched 1:1 with a cohort of patients undergoing OSS...
October 1, 2016: Journal of Minimally Invasive Gynecology
(no author information available yet)
The Equal Employment Opportunity Commission (EEOC or Commission) is issuing a final rule to amend the regulations implementing Title II of the Genetic Information Nondiscrimination Act of 2008 as they relate to employer-sponsored wellness programs. This rule addresses the extent to which an employer may offer an inducement to an employee for the employee's spouse to provide information about the spouse's manifestation of disease or disorder as part of a health risk assessment (HRA) administered in connection with an employer-sponsored wellness program...
May 17, 2016: Federal Register
(no author information available yet)
The Equal Employment Opportunity Commission (EEOC or Commission) is issuing its final rule to amend the regulations and interpretive guidance implementing Title I of the Americans with Disabilities Act (ADA) to provide guidance on the extent to which employers may use incentives to encourage employees to participate in wellness programs that ask them to respond to disability-related inquiries and/or undergo medical examinations. This rule applies to all wellness programs that include disability-related inquiries and/or medical examinations whether they are offered only to employees enrolled in an employer-sponsored group health plan, offered to all employees regardless of whether they are enrolled in such a plan, or offered as a benefit of employment by employers that do not sponsor a group health plan or group health insurance...
May 17, 2016: Federal Register
Rui G Vaz, Pascal Mkanda, Richard Banda, William Komkech, Olubowale O Ekundare-Famiyesin, Rosemary Onyibe, Sunday Abidoye, Peter Nsubuga, Sylvester Maleghemi, Bolatito Hannah-Murele, Sisay G Tegegne
BACKGROUND: The current West African outbreak of the Ebola virus disease (EVD) began in Guinea in December 2013 and rapidly spread to Liberia and Sierra Leone. On 20 July 2014, a sick individual flew into Lagos, Nigeria, from Monrovia, Liberia, setting off an outbreak in Lagos and later in Port Harcourt city. The government of Nigeria, supported by the World Health Organization and other partners, mounted a response to the outbreak relying on the polio program experiences and infrastructure...
May 1, 2016: Journal of Infectious Diseases
(no author information available yet)
No abstract text is available yet for this article.
February 2015: AIDS Policy & Law
Antonino Ditto, Fabio Martinelli, Giorgio Bogani, Domenica Lorusso, Marialuisa Carcangiu, Valentina Chiappa, Claudio Reato, Cristina Donfrancesco, Karla Jeanette Amaya De Carrillo, Francesco Raspagliesi
OBJECTIVE: Fertility-sparing surgery (FSS) is a strategy often considered in young patients with low-grade (G1-2) early-stage epithelial ovarian cancer (eEOC), while is still controversial in high-risk patients. We investigated the role of FSS in low and high-risk eEOC patients undergoing comprehensive surgical staging. METHODS: We analyzed data from patients operated for an eEOC from 1975 to 2011, focusing on patients submitted to FSS. Seventy patients out of 307 with eEOC were identified...
July 2015: Gynecologic Oncology
Richard Mark Kirkner
No abstract text is available yet for this article.
January 2015: Managed Care
(no author information available yet)
Reasonable accommodation may require providing individual with disabilities a vacant position even if the individual is not the most qualified applicant.
2014: Benefits Quarterly
Antonino Ditto, Fabio Martinelli, Domenica Lorusso, Edward Haeusler, Marialuisa Carcangiu, Francesco Raspagliesi
OBJECTIVE: Fertility sparing surgery (FSS) is a strategy often considered in young patients with early epithelial ovarian cancer. We investigated the role and the outcomes of FSS in eEOC patients who underwent comprehensive surgery. METHODS: From January 2003 to January 2011, 24 patients underwent fertility sparing surgery. Eighteen were one-to-one matched and balanced for stage, histologic type and grading with a group of patients who underwent radical comprehensive staging (n=18)...
October 2014: Journal of Gynecologic Oncology
D Patschan, K Schwarze, E Henze, J U Becker, S Patschan, G A Müller
Diabetic nephropathy is the most frequent single cause of end-stage renal disease in our society. Microvascular damage is a key event in diabetes-associated organ malfunction. Early endothelial outgrowth cells (eEOCs) act protective in murine acute kidney injury. The aim of the present study was to analyze consequences of eEOC treatment of murine diabetic nephropathy with special attention on endothelial-to-mesenchymal transdifferentiation, autophagy, senescence, and apoptosis. Male C57/Bl6N mice (8-12 wk old) were treated with streptozotocin for 5 consecutive days...
September 15, 2014: American Journal of Physiology. Renal Physiology
Jung-Yun Lee, Hee Seung Kim, Hyun Hoon Chung, Jae Weon Kim, Noh Hyun Park, Yong-Sang Song
BACKGROUND: Comprehensive surgical staging plays an important role in apparent early-stage epithelial ovarian cancer (eEOC). However, few studies have evaluated how often upstaging occurs solely as a result of microscopic metastases identified from omentectomy and random peritoneal biopsies. The purpose of this study was to evaluate the significance of omentectomy and random peritoneal biopsies for normal-appearing tissues in eEOC. METHODS: A retrospective study was performed of patients with eEOC [International Federation of Gynecology and Obstetrics (FIGO) Stages I-IIIA] between 1991 and 2010...
August 2014: Annals of Surgical Oncology
Daniel Patschan, Katrin Schwarze, Elvira Henze, Susann Patschan, Roman Scheidemann, Gerhard Anton Müller
BACKGROUND: Early endothelial outgrowth cells (eEOCs) protect mice from acute kidney injury (AKI). Peroxisome proliferator-activated receptor-alpha (PPAR-α) has been shown to mediate renoprotective effects under different experimental conditions. The aim of the study was to investigate consequences of fibrate treatment of murine eEOCs in a cell-based therapeutic approach to AKI. METHODS: Male C57/Bl6N mice, subjected to unilateral renal ischemia (40 min) post-uninephrectomy, were systemically injected with 0...
February 2014: Journal of Nephrology
Paul E Terry
No abstract text is available yet for this article.
February 2014: Population Health Management
Daniel Patschan, Jörg Rinneburger, Nazif Idrizi, Rico Backhaus, Katrin Schwarze, Elvira Henze, Susann Patschan, Gerhard A Müller
BACKGROUND: Acute kidney injury (AKI) severely worsens prognosis of hospitalized patients. Early Endothelial Outgrowth Cells act protective in murine acute ischemic renal failure and renoprotective actions of eEOCs have been documented to increase after cell pretreatment with 8-O-cAMP and Melatonin. Angiopoietin-1 is critically involved in maintaining vascular integrity and regeneration. Aim of the study was to analyze the consequences of eEOC treatment with Ang-1 in murine AKI. METHODS: After 40 minutes of unilateral renal artery clamping with contralateral nephrectomy, male C57/Bl6N mice were injected with either untreated or pretreated (Ang-1) syngeneic murine eEOCs...
2013: BMC Nephrology
William R Draper, Carolyn E Hawley, Brian T McMahon, Christine A Reid, Lara A Barbir
INTRODUCTION: The purpose of this study is to examine the possible interactions of predictor variables pertaining to perceived disability claims contained in a large governmental database. Specifically, it is a retrospective analysis of US Equal Employment Opportunity Commission (EEOC) data for the entire population of workplace discrimination claims based on the "regarded as disabled" prong of the Americans with Disabilities Act (ADA) definition of disability. METHODS: The study utilized records extracted from a "master database" of over two million charges of workplace discrimination in the Integrated Mission System of the EEOC...
June 2014: Journal of Occupational Rehabilitation
Shu Wang, Lin Qiu, Jing He Lang, Keng Shen, Hui Fang Huang, Ling Ya Pan, Ming Wu, Jia Xin Yang, Li Na Guo
OBJECTIVE: Clinicopathological characteristics and possible prognostic factors among women with endometrioid epithelial ovarian cancer (EEOC) with or without concurrent endometriosis were investigated. STUDY DESIGN: A search of medical charts at Peking Union Medical College Hospital from 2000 through 2012 identified patients with EEOC with or without endometriosis. RESULTS: Of 188 patients with EEOC, concurrent endometriosis was identified in 32 (17...
September 2013: American Journal of Obstetrics and Gynecology
Daniel Patschan, Katrin Schwarze, Andrea Lange, Nyree Meise, Elvira Henze, Jan Ulrich Becker, Susann Patschan, Gerhard A Müller
Early endothelial outgrowth cells (eEOCs) reproducibly have been shown to act protectively in acute ischemic kidney injury (AKI) and chronic kidney injury. Bone morphogenetic protein-5 (BMP-5) acted antifibrotically in human hypertensive nephropathy. The aim of the current study was to analyze effects of BMP-5 treatment in an eEOC-based therapy of murine AKI and 5/6-nephrectomy. Male C57/Bl6N mice were either subjected to unilateral renal artery clamping postuninephrectomy or to 5/6-nephrectomy. Untreated or BMP-5-pretreated murine eEOCs were injected into recipient animals at the time of reperfusion (AKI) or at 2 and 5 days after 5/6-nephrectomy...
August 1, 2013: American Journal of Physiology. Renal Physiology
Daniel Patschan, Rico Backhaus, Hans-Jörg Elle, Katrin Schwarze, Elvira Henze, Jan Ulrich Becker, Susann Patschan, Gerhard Anton Müller
BACKGROUND: Early endothelial outgrowth cells (eEOCs) significantly protect mice from acute kidney injury (AKI). Angiopoietin-2 (Ang-2) has been shown to be critically involved in vascular repair and homeostasis. The aim of this study was to investigate consequences of Ang-2 treatment of syngeneic murine eEOCs in a cell-based therapeutic approach for AKI. METHODS: Male 8- to 12-week-old C57/Bl6N mice, subjected to unilateral renal ischemia (40 minutes) postuninephrectomy were systemically injected with 0...
July 2013: Journal of Nephrology
Juan Carlos Arango-Lasprilla, Jessica M Ketchum, Jessica Hurley, Almaz M Getachew, Kelli Williams Gary
BACKGROUND: Approximately 25% of working-aged Americans with disabilities work full or part time, yet still face discrimination despite the passing of the American's with Disabilities Act (ADA) over 20 years ago. OBJECTIVES: To determine if the proportion of allegations of ADA Title I workplace discrimination with merit closed at any year between 1993 and 2008 differs among Whites, African Americans, Hispanics, and Asians; to determine if there was a change over time from 1993 to 2008 in merit closure rate within each race/ethnicity group; and to determine whether changes over time between 1993 and 2008 in the merit closure rate differ among the race/ethnicity groups...
2014: Work: a Journal of Prevention, Assessment, and Rehabilitation
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