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https://www.readbyqxmd.com/read/29458059/modest-enhancement-of-sensory-axon-regeneration-in-the-sciatic-nerve-with-conditional-co-deletion-of-pten-and-socs3-in-the-dorsal-root-ganglia-of-adult-mice
#1
Zachary R Gallaher, Oswald Steward
Axons within the peripheral nervous system are capable of regeneration, but full functional recovery is rare. Recent work has shown that conditional deletion of two key signaling inhibitors of the PI3K and Jak/Stat pathways-phosphatase and tensin homolog (PTEN) and suppressor of cytokine signaling-3 (SOCS3), respectively-promotes regeneration of normally non-regenerative central nervous system axons. Moreover, in studies of optic nerve regeneration, co-deletion of both PTEN and SOCS3 has an even greater effect...
February 16, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29457436/-clinical-application-of-tibial-composite-saphenous-nervetissue-flap-for-the-treatment-of-traumatic-bone-skin-defect-of-leg
#2
Zhi-Wei Zhao, Wen-Jing Liu, Zhu-Qing Zha, Yan-Feng Li, Hui-Jun Fan
OBJECTIVE: To investigate the effect of tibial composite saphenous nerve tissue flap in repairing traumatic bone-skin defect of leg. METHODS: From February 2009 to May 2015, 23 patients with focile skin defect caused by trauma were treated, including 18 males and 5 females, aged from 8 to 59 years old with an average age of 35.6 years old. Length of tibia bone cortex defect ranged from 4 to 12 cm, width ranged from 2 to 2.5cm, skin defect ranged from 8 cm× 3 cm to 18 cm× 11 cm, all the wound surfaces had purulent exudation...
December 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457424/-progress-on-diagnosis-and-treatment-of-proximal-tibiofibular-joint-dislocation
#3
REVIEW
Bin Yuan, Bao-Jian Ge, Bai-Yi Meng
Dislocation of proximal tibiofibular joint(PTFJ) is relatively infrequent in clinic, it can be either isolated or associated with tibia fracture, fibular fracture and ankle injury and so on. Chronic symptomatic PTFJ instability are easily mixed with meniscal tears. It was easily neglected because of the mild clinical presentation and atypical change on radiography. Early diagnosis and treatment are crucial to prevent chronic knee pain and instability. The paper concluded the anatomy, classification, complication, diagnosis, treatment, clinical effect and insufficient of the dislocation of PTFJ, to direct the diagnosis and treatment of proximal tibiofibular joint dislocation in clinical work...
October 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457399/-osseous-bridge-resection-for-the-treatment-of-adult-talocalaneal-coalitions-without-arthritis
#4
Bing Xie, Shuo Yan, Hao Zhang, Yuan-Wei Wang, Jing Tian
OBJECTIVE: To analyze clinical outcomes of osseous-bridge resection for the treatment of adult symptomatic talocalcaneal coalitions without arthritis. METHODS: The clinical data of 12 patients (15 feet) with symptomatic talocalcaneal coalitions without arthtitis from January 2013 to June 2016 were respectively analyzed. All cases were secondary talocalcaneal coalition. There were 9 males (11 feet) and 3 females (4 feet) with a mean (26.6±3.3) years old (ranged, 18 to 33 years old)...
November 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29457148/platelets-at-the-vascular-interface
#5
Wolfgang Bergmeier, Lucia Stefanini
In this brief review paper, we will summarize the State-of-the-Art on how platelet reactivity is regulated in circulation and at sites of vascular injury. Our review discusses recent and ongoing work, presented at this year's International Society on Thrombosis and Haemostasis (ISTH) meeting, on the role of platelets in (1) classical hemostasis at sites of mechanical injury, and (2) the maintenance of vascular integrity at sites of inflammation.
January 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29456833/work-related-acute-physical-injuries-chronic-overuse-complaints-and-the-psychosocial-work-environment-in-danish-primary-care-chiropractic-practice-a-cross-sectional-study
#6
Mille Charlotte Hansen, Tine Aagaard, Henrik Wulff Christensen, Jan Hartvigsen
Background: Little is known about the physical and psychosocial work environment of chiropractors and their work-related health complaints, and this has never been described for Danish chiropractors. The aim of this study was, therefore, to describe work-related acute physical injuries, overuse complaints, and psychosocial stress in Danish chiropractic work settings. Methods: We developed a questionnaire specifically for this study and distributed it electronically in August 2016 using SurveyXact to all 575 members of the Danish Chiropractors' Association working in primary care clinics...
2018: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/29455634/early-predictors-of-global-functional-outcome-after-traumatic-spinal-cord-injury-a-systematic-review
#7
Andreane Richard-Denis, Marie Beauséjour, Cynthia Thompson, Bich-Han Nguyen, Jean-Marc Mac-Thiong
Accurately predicting functional recovery in an asset for all clinicians and decision makers involved in the care of patients with acute traumatic spinal cord injury (TSCI). Unfortunately, there is a lack of information on the relative importance of significant predictors of global functional outcome. There is also a need for identifying functional predictors that can be timely optimized by the medical and rehabilitation teams throughout the hospitalizations phases. The main objective of this work was to systematically review and rate early factors that are consistently and independently associated with global functional outcome in individuals with TSCI...
February 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29454374/effects-of-umbilical-cord-blood-cells-and-subtypes-to-reduce-neuroinflammation-following-perinatal-hypoxic-ischemic-brain-injury
#8
Courtney A McDonald, Tayla R Penny, Madison C B Paton, Amy E Sutherland, Lakshmi Nekkanti, Tamara Yawno, Margie Castillo-Melendez, Michael C Fahey, Nicole M Jones, Graham Jenkin, Suzanne L Miller
BACKGROUND: It is well understood that hypoxic-ischemic (HI) brain injury during the highly vulnerable perinatal period can lead to cerebral palsy, the most prevalent cause of chronic disability in children. Recently, human clinical trials have reported safety and some efficacy following treatment of cerebral palsy using umbilical cord blood (UCB) cells. UCB is made up of many different cell types, including endothelial progenitor cells (EPCs), T regulatory cells (Tregs), and monocyte-derived suppressor cells (MDSCs)...
February 17, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29454061/activation-of-nlrx1-mediated-autophagy-accelerates-the-ototoxic-potential-of-cisplatin-in-auditory-cells
#9
Haiyan Yin, Qianqian Yang, Zhixin Cao, Hongrui Li, Zhaoyan Yu, Guodong Zhang, Gaoying Sun, Rongjun Man, Haibo Wang, Jianfeng Li
To date, the mechanism (s) underlying the cisplatin-elicited ototoxicity has not been elucidated fully. Nucleotide-binding domain and leucine-rich-repeat-containing family member ×1 (NLRX1), a cytoplasmic pattern recognition receptor, is tightly related to mitochondrial function, reactive oxygen species (ROS) production, and autophagy. In this work, autophagy alteration, NLRX1 expression, ROS generation and cell injury were investigated correspondingly by immunofluorescence staining, western-blot, TEM, flow cytometry and MTT in HEI-OC1 cells of both NLRX1 overexpression and silencing in response to cisplatin stimulus...
February 14, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29453272/building-the-child-safety-collaborative-innovation-and-improvement-network-how-does-it-work-and-what-is-it-achieving
#10
Jennifer B Leonardo, Rebecca S Spicer, Maria Katradis, Jennifer Allison, Rebekah Thomas
OBJECTIVE: This study investigated whether the Child Safety Collaborative Innovation and Improvement Network (CS CoIIN) framework could be applied in the field of injury and violence prevention to reduce fatalities, hospitalizations and emergency department visits among 0-19 year olds. SAMPLE: Twenty-one states/jurisdictions were accepted into cohort 1 of the CS CoIIN, and 14 were engaged from March 2016 through April 2017. A quality improvement framework was used to test, implement and spread evidence-based change ideas (strategies and programs) in child passenger safety, falls prevention, interpersonal violence prevention, suicide and self-harm prevention and teen driver safety...
February 16, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29452281/incidence-and-risk-factors-of-post-operative-neurological-decline-after-complex-adult-spinal-deformity-surgery-results-of-the-scoli-risk-1-study
#11
Michael G Fehlings, So Kato, Lawrence G Lenke, Hiroaki Nakashima, Narihito Nagoshi, Christopher I Shaffrey, Kenneth M C Cheung, Leah Carreon, Mark B Dekutoski, Frank J Schwab, Oheneba Boachie-Adjei, Khaled M Kebaish, Christopher P Ames, Yong Qiu, Yukihiro Matsuyama, Benny T Dahl, Hossein Mehdian, Ferran Pellisé-Urquiza, Stephen J Lewis, Sigurd H Berven
BACKGROUND CONTEXT: Significant variability in neurologic outcomes following surgical correction for adult spinal deformity (ASD) has been reported. Risk factors for decline in neurologic motor outcomes are poorly understood. PURPOSE: The objective of the present investigation was to identify the risk factors for post-operative neurological motor decline in patients undergoing complex ASD surgery. STUDY DESIGN/SETTING: A prospective international multicenter cohort study...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29451714/development-of-regenerative-and-flexible-fibroin-based-wound-dressings
#12
Angelica Panico, Federica Paladini, Mauro Pollini
Skin injuries represent a health problem with consequences in terms of morbidity, disability and life quality. Numerous strategies have been developed for the treatment of wounds, including skin substitutes, biomembranes, scaffolds, and smart dressings. The excellent properties of fibroin can be exploited for the development of advanced wound dressing biomaterials, aiming at promoting the wound healing process. In this work, silk fibroin films modified through the addition of glucose were developed to enhance flexibility of medical device without affecting the biocompatibility, to promote wound healing and to improve the patient well-being...
February 16, 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29451335/mesenchymal-stem-cells-protect-against-hypoxia-ischemia-brain-damage-by-enhancing-autophagy-through-bdnf-mtor-signaling-pathway
#13
Zhen Zheng, Li Zhang, Yi Qu, Guoguang Xiao, Shiping Li, Shan Bao, Richard Lu, Dezhi Mu
Hypoxic-ischemic encephalopathy (HIE) is a serious disease for neonates. However, present therapeutic strategies are not effective enough for treating HIE. Previous study showed that mesenchymal stem cells (MSCs) can exert neuroprotective effects for brain damage, but its mechanism remains elusive. Using in-vitro co-culture of rat cortical primary neurons and MSCs in HI conditions, we demonstrated that MSCs help increase BDNF and autophagy markers (LC3II and Beclin1) in the cultures and decrease cells death (LDH levels)...
February 16, 2018: Stem Cells
https://www.readbyqxmd.com/read/29450896/circadian-mechanisms-in-alcohol-use-disorder-and-tissue-injury
#14
Booker T Davis, Robin M Voigt, Maliha Shaikh, Christopher B Forsyth, Ali Keshavarzian
Heavy use of alcohol can lead to addictive behaviors and to eventual alcohol related tissue damage. While increased consumption of alcohol has been attributed to various factors including level of alcohol exposure and environmental factors such as stress, data from behavioral scientists and physiological researchers is revealing roles for the circadian rhythm in mediating the development of behaviors associated with alcohol use disorder as well as the tissue damage that drives physiological disease. In this work, we compile recent work on the complex mutually influential relationship that exists between the core circadian rhythm and the pharmacodynamics of alcohol...
February 16, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29450484/neurological-manifestations-among-us-government-personnel-reporting-directional-audible-and-sensory-phenomena-in-havana-cuba
#15
Randel L Swanson, Stephen Hampton, Judith Green-McKenzie, Ramon Diaz-Arrastia, M Sean Grady, Ragini Verma, Rosette Biester, Diana Duda, Ronald L Wolf, Douglas H Smith
Importance: From late 2016 through August 2017, US government personnel serving on diplomatic assignment in Havana, Cuba, reported neurological symptoms associated with exposure to auditory and sensory phenomena. Objective: To describe the neurological manifestations that followed exposure to an unknown energy source associated with auditory and sensory phenomena. Design, Setting, and Participants: Preliminary results from a retrospective case series of US government personnel in Havana, Cuba...
February 15, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29448054/rage-induced-changes-in-the-proteome-of-alveolar-epithelial-cells
#16
Charles A Downs, Nicholle M Johnson, George Tsaprailis, My N Helms
The receptor for advanced glycation end-products (RAGE) is a pattern recognition receptor and member of the immunoglobulin superfamily. RAGE is constitutively expressed in the distal lung where it co-localizes with the alveolar epithelium; RAGE expression is otherwise minimal or absent, except with disease. This suggests RAGE plays a role in lung physiology and pathology. We used proteomics to identify and characterize the effects of RAGE on rat alveolar epithelial (R3/1) cells. LC-MS/MS identified 177 differentially expressed proteins and the PANTHER Classification System further segregated proteins...
February 12, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29447234/folic-acid-derived-p5779-mimetics-regulate-damp-mediated-inflammation-through-disruption-of-hmgb1-tlr4-md-2-axes
#17
Shan Sun, Mingzhu He, Yongjun Wang, Huan Yang, Yousef Al-Abed
High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) protein that mediates inflammatory responses after infection or injury. Previously, we reported a peptide inhibitor of HMGB1 (P5779) that acts by directly interrupting HMGB1/MD-2 binding. Here, fingerprint similarity search and docking studies suggest folic acid derived-drugs function as P5779 mimetopes. Molecular dynamic (MD) simulation studies demonstrate that folic acid mimics the binding of P5779 at the TLR4 and MD-2 intersection...
2018: PloS One
https://www.readbyqxmd.com/read/29447154/examining-the-controllability-of-sepsis-using-genetic-algorithms-on-an-agent-based-model-of-systemic-inflammation
#18
Robert Chase Cockrell, Gary An
Sepsis, a manifestation of the body's inflammatory response to injury and infection, has a mortality rate of between 28%-50% and affects approximately 1 million patients annually in the United States. Currently, there are no therapies targeting the cellular/molecular processes driving sepsis that have demonstrated the ability to control this disease process in the clinical setting. We propose that this is in great part due to the considerable heterogeneity of the clinical trajectories that constitute clinical "sepsis," and that determining how this system can be controlled back into a state of health requires the application of concepts drawn from the field of dynamical systems...
February 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29446112/variability-in-cross-domain-risk-perception-among-smallholder-farmers-in-mali-by-gender-and-other-demographic-and-attitudinal-characteristics
#19
Alison C Cullen, C Leigh Anderson, Pierre Biscaye, Travis W Reynolds
Previous research has shown that men and women, on average, have different risk attitudes and may therefore see different value propositions in response to new opportunities. We use data from smallholder farm households in Mali to test whether risk perceptions differ by gender and across domains. We model this potential association across six risks (work injury, extreme weather, community relationships, debt, lack of buyers, and conflict) while controlling for demographic and attitudinal characteristics. Factor analysis highlights extreme weather and conflict as eliciting the most distinct patterns of participant response...
February 15, 2018: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29445503/overview-of-occupational-cancer-in-painters-in-korea
#20
REVIEW
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Comprehensive consideration is necessary for setting guidelines to evaluate evidence of occupational cancer in painters due to work-related exposure to carcinogens in paint (a phenomenon termed herein as "work-relatedness"). The aim of the present research is to perform a comprehensive review and to suggest criteria for the provision of compensation for occupational neoplasm among painters in Korea. In order to perform a comprehensive review, this study assessed and evaluated scientific reports of carcinogenicities from the International Agency for Research on Cancer (IARC) and the Industrial Injuries Advisory Council (IIAC), as well as reviewed the existing literature about occupational exposure among painters in Korea and the epidemiologic investigations of claimed cases of cancer among painters in Korea...
2018: Annals of Occupational and Environmental Medicine
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