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https://www.readbyqxmd.com/read/29656073/protective-therapeutic-effects-of-peptide-nanofiber-and-hyaluronic-acid-hybrid-membrane-in-in-vivo-osteoarthritis-model
#1
Elif Arslan, Melis Sardan Ekiz, Cagla Eren Cimenci, Nuray Can, M Hanifi Gemci, Huseyin Ozkan, Mustafa O Guler, Ayse B Tekinay
Osteoarthritis (OA) is a condition where tissue function is lost through a combination of secondary inflammation and deterioration in articular cartilage. One of the most common causes of OA is age-related tissue impairment because of wear and tear due to mechanical erosion. Hyaluronic acid-based viscoelastic supplements have been widely used for the treatment of knee injuries. However, the current formulations of hyaluronic acid are unable to provide efficient healing and recovery. Here, a nanofiber-hyaluronic acid membrane system that was prepared by using a quarter of the concentration of commercially available hyaluronic acid supplement, Hyalgan® , was used for the treatment of an osteoarthritis model, and Synvisc® , which is another commercially available hyaluronic acid containing viscoelastic supplement, was used as a control...
April 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29653319/analysis-of-fatal-accidents-with-tractors-in-the-centre-of-portugal-ten-years-analysis
#2
Soraia M Antunes, Cristina Cordeiro, Helena M Teixeira
Tractors have been described as one of the deadliest farming implements concerning agricultural activity. In Portugal, the scientific investigations about this problem are practically non-existent, with only statistical studies performed by entities related to road traffic safety, not in accordance to the study now performed, pinpointing the possibility of an underreporting of these accidents. This work aims to characterize the fatal tractor accidents in Portugal, autopsied at the Forensic Pathology Department of the Centre Branch of the National Institute of Legal Medicine and Forensic Sciences of Portugal, analysing several variables: gender, age, occupation, survival time, the victim position in the tractor, cause of death, toxicological and histological exams, year/month/day of the week, type of agricultural machine, existence of rollover protective structures (ROPS), type of accident, ground conditions, circumstantial information and geographic distribution of the accidents...
April 6, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29653188/ketamine-reduces-deleterious-consequences-of-spreading-depolarizations
#3
Katelyn M Reinhart, C William Shuttleworth
Recent work has implicated spreading depolarization (SD) as a key contributor the progression of acute brain injuries, however development of interventions selectively targeting SDs has lagged behind. Initial clinical intervention efforts have focused on observations that relatively high doses of the sedative agent ketamine can completely suppress SD. However blocking propagation of SD could theoretically prevent beneficial effects of SD in surrounding brain regions. Selective targeting of deleterious consequences of SD (rather than abolition) could be a useful adjunct approach, and be achieved with lower ketamine concentrations...
April 10, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29652231/endoscopic-endonasal-transoculomotor-triangle-approach-for-adenomas-invading-the-parapeduncular-space-surgical-anatomy-technical-nuances-and-case-series
#4
Cristian Ferrareze Nunes, Stefan Lieber, Huy Q Truong, Georgios Zenonos, Eric W Wang, Carl H Snyderman, Paul A Gardner, Juan C Fernandez-Miranda
OBJECTIVE Pituitary adenomas may extend into the parapeduncular space by invading through the roof of the cavernous sinus. Currently, a transcranial approach is the preferred choice, with or without the combination of an endonasal approach. In this paper the authors present a novel surgical approach that takes advantage of the natural corridor provided by the tumor to further open the oculomotor triangle and resect tumor extension into the parapeduncular space. METHODS Six injected specimens were used to demonstrate in detail the surgical anatomy related to the approach...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29650223/surgeons-muscle-load-during-robotic-assisted-laparoscopy-performed-with-a-regular-office-chair-and-the-preferred-of-two-ergonomic-chairs-a-pilot-study
#5
T Dalager, P T Jensen, T S Winther, T R Savarimuthu, A Markauskas, O Mogensen, K Søgaard
Surgeons work in awkward work postures and have high precision demands - well-known risk factors for musculoskeletal pain. Robotic-assisted laparoscopy is expected to be less demanding compared to conventional laparoscopy; however, studies indicate that robotic-assisted laparoscopy is also associated with poor ergonomics and musculoskeletal pain. The ergonomic condition in the robotic console is partially dependent upon the chair provided, which often is a regular office chair. Our study quantified and compared the muscular load during robotic-assisted laparoscopy using one of two custom built ergonomic chairs and a regular office chair...
April 9, 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/29649186/current-marijuana-use-by-industry-and-occupation-colorado-2014-2015
#6
Roberta Smith, Katelyn E Hall, Paul Etkind, Mike Van Dyke
The effects of marijuana use on workplace safety are of concern for public health and workplace safety professionals. Twenty-nine states and the District of Columbia have enacted laws legalizing marijuana at the state level for recreational and/or medical purposes. Employers and safety professionals in states where marijuana use is legal have expressed concerns about potential increases in occupational injuries, such as on-the-job motor vehicle crashes, related to employee impairment. Data published in 2017 by the Colorado Department of Public Health and Environment (CDPHE) showed that more than one in eight adult state residents aged ≥18 years currently used marijuana in 2014 (13...
April 13, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29648974/traumatic-brain-injury-induced-acute-lung-injury-evidence-for-activation-and-inhibition-of-a-neural-respiratory-inflammasome-axis
#7
Nadine Kerr, Juan Pablo De Rivero Vaccari, Sam Abbassi, Harmanpreet Kaur, Ronald Zambrano, Shu Wu, W Dalton Dietrich, Robert W Keane
Approximately 20-25 percent of Traumatic Brain Injury subjects develop Acute Lung Injury (ALI), but the pathomechanisms of TBI-induced ALI remain poorly defined. Our previous work has shown that the inflammasome plays a critical role in TBI-induced secondary pathophysiology and that inflammasome proteins are released in Extracellular Vesicles (EV) after TBI. Here we investigated whether EV-mediated inflammasome signaling contributed to the etiology of TBI-induced ALI. C57/BL6 male mice were subjected to controlled cortical impact, and the brains and lungs were examined for inflammasome activation and ALI at 4 hours and 24 hours after TBI...
March 5, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29648957/asthma-among-household-youth-on-racial-minority-operated-farms-united-states-2008
#8
Girija Syamlal, Kitty Hendricks, Jacek M Mazurek
OBJECTIVES: Youth on farms are at risk for injuries and illnesses, including asthma, which continues to disproportionately affect minority groups. METHODS: For this study, the 2008 Minority Farm Operator Childhood Agricultural Injury Survey (M-CAIS) data were used to estimate the prevalence of asthma among youth aged 0-19 years living on racial minority-operated farms. Youth were considered to have a lifetime diagnosis of asthma based on an affirmative response to the question "Has he/she ever been diagnosed as having asthma by a health professional?" RESULTS: In 2008, of the estimated 37,400 youth (0-19 years) who lived on racial minority operated farms, 11% had asthma...
2018: Journal of Agromedicine
https://www.readbyqxmd.com/read/29648954/what-happens-to-the-farm-australian-farmers-experiences-after-a-serious-farm-injury
#9
Jessica Beattie, Candis McLeod, Meg Murray, Daryl Pedler, Susan Brumby, Belinda Gabbe
OBJECTIVES: To investigate the experiences of farmers on returning to farming following a serious farm-related injury. METHODS: Patients who had sustained major trauma on a farm in Victoria, Australia, were identified using the Victorian State Trauma Registry (VSTR). In depth, semistructured phone interviews were conducted with 31 participants. Interview data were subjected to thematic analysis to identify important recurring themes. Interviews continued until data saturation was achieved...
2018: Journal of Agromedicine
https://www.readbyqxmd.com/read/29644100/persistent-urine-leakage-around-a-suprapubic-catheter-the-experience-of-a-person-with-chronic-tetraplegia
#10
Subramanian Vaidyanathan, Jerry Ward, Bakul M Soni, Peter Hughes, Tun Oo
Introduction: Persistent urine leakage after suprapubic cystostomy in tetraplegic subjects occurs due to shrinkage of the urinary bladder and bladder spasms. The patient's social life is adversely affected as clothes become wet, smelly, and require frequent changing, thus increasing the workload of carers. Case presentation: A 48-year-old male sustained C-4 complete (AIS:A) tetraplegia while swimming in 2007. Suprapubic cystostomy was performed in 2009. From 2012, this patient had urine leakage around the suprapubic catheter, which became progressively more frequent...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29643759/changes-in-h-reflex-recruitment-after-trans-spinal-direct-current-stimulation-with-multiple-electrode-configurations
#11
Alexander Kuck, Dick F Stegeman, Herman van der Kooij, Edwin H F van Asseldonk
Trans-spinal direct current stimulation (tsDCS) is an electro-modulatory tool with possible application in the rehabilitation of spinal cord injury. TsDCS generates a small electric field, aiming to induce lasting, functional neuromodulation in the targeted neuronal networks. Earlier studies have shown significant modulatory effects after application of lumbar tsDCS. However, for clinical application, a better understanding of application specific factors is required. Our goal was to investigate the effect of different electrode configurations using lumbar spinal tsDCS on spinal excitability...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29643536/-genetic-diagnosis-of-caroli-syndrome-with-autosomal-recessive-polycystic-kidney-disease-a-case-report-and-literature-review
#12
X Y Yang, L P Zhu, X Q Liu, C Y Zhang, Y Yao, Y Wu
This case report is about one genetically specified diagnosed infant case of Caroli syndrome with autosomal recessive polycystic kidney disease (ARPKD) in China. The patient in this case report was an eight-month infant boy with an atypical onset and the main clinical manifestation was non-symptomatic enlargement of the liver and kidneys. The imaging study demonstrated a diffused cystic dilatation of intrahepatic bile ducts as well as polycystic changes in bilateral kidneys. The basic blood biochemical tests indicated a normal hepatorenal function...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29630130/inhibitive-effects-of-microrna-34a-on-protecting-against-ischemia-reperfusion-injury-of-vital-organs-in-hemorrhagic-shock-pregnant-mice
#13
L-B Qin, Z-Y Li, H Li, X-Q Fan, H-G Liu, X-M Dong, W-Y Jia
OBJECTIVE: Hemorrhagic shock is a common vital condition in obstetrics, and major treatment consists of bleeding control and liquid resuscitation. MicroRNA (miR) has been found to regulate multiple diseases. However, its expression profile in hemorrhagic shock or effects on the ischemia-reperfusion injury in pregnant mice has not been reported yet. PATIENTS AND METHODS: This study generated rat hemorrhagic shock pregnant model, on which real-time quantitative PCR was used to measure miR-34a expressions...
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29628712/best-care-paradigm-to-optimize-functionality-after-extra-articular-distal-humeral-fractures-in-the-young-patient
#14
REVIEW
Mark S Ayoub, Ivan S Tarkin
For younger patients with extra-articular distal humerus fractures closed management is plagued with high rates of malunion, suboptimal functional outcomes, extended immobilization with loss of early motion, a delay in return to work, and a general period of lost productivity. Surgical management offers an appealing alternative. Maintaining respect for the triceps musculature and minimizing iatrogenic injury to the radial nerve are primary concerns with operative treatment. Accordingly, use of a triceps-sparing approach and single column plating may be the optimal treatment paradigm in the young patient presenting with an extra-articular distal humerus fracture...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628697/seasonal-variation-in-orthopedic-trauma-patients-an-experience-from-central-india
#15
Rajeev Shukla, Nikhil Jain, Utkarsh Agarwal, Tanveer Sheikh, Ravikant Jain
Objectives: This study aims to determine the various epidemiological factors responsible for orthopedic trauma cases: how do weather patterns, month, season and public working schedule influence the daily frequency of orthopedic trauma. Material and methods: This was a descriptive study performed in the Department of Orthopedics at a tertiary care centre in central India Participants: 7980 trauma cases reported in our study period. Study variables: Demographic characteristics of the cases, time, day, the month of injury and type of trauma and cause of trauma...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29628670/bilateral-hip-dislocation-an-indicator-for-emergent-full-body-computed-tomography-scan-in-polytraumatized-patients-a-case-report-and-review-of-the-literature
#16
Benjamin Rufer, Marius Johann Baptist Keel, Beat Schnüriger, Moritz Caspar Deml
We present a rare case of traumatic bilateral asymmetric hip dislocation with pelvic fractures and a traumatic diaphragmatic hernia. A 53-year-old machinist was transferred to our emergency department with the suspicion of a bilateral hip dislocation after he was trapped between an elevator and the roof. Immediate closed reduction of the hips was not performed because of the expected risk of increasing hemodynamic instability with muscular relaxation. An emergent full-body computed tomography (CT) scan was made to assess injuries with need for further operative treatment...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29628667/early-predictive-factors-of-hypofibrinogenemia-in-acute-trauma-patients
#17
Shahram Paydar, Behnam Dalfardi, Zahra Shayan, Leila Shayan, Jalal Saem, Shahram Bolandparvaz
Background: Uncontrolled hemorrhage still remains a major cause of trauma-associated mortality. The events resulting in acute traumatic coagulopathy, particularly hypofibrinogenemia, make control of bleeding difficult. It is essential to timely predict, diagnose, and manage trauma-induced coagulopathy. Aims: The aim of this study is to determine clinical and easily available laboratory variables that are predictive of hypofibrinogenemia in acute trauma patients...
January 2018: Journal of Emergencies, Trauma, and Shock
https://www.readbyqxmd.com/read/29625691/the-relation-between-working-conditions-aberrant-driving-behaviour-and-crash-propensity-among-taxi-drivers-in-china
#18
Yonggang Wang, Linchao Li, Carlo G Prato
Although the taxi industry is playing an important role in Chinese everyday life, little attention has been posed towards occupational health issues concerning the taxi drivers' working conditions, driving behaviour and road safety. A cross-sectional survey was administered to 1021 taxi drivers from 21 companies in four Chinese cities and collected information about (i) sociodemographic characteristics, (ii) working conditions, (iii) frequency of daily aberrant driving behaviour, and (iv) involvement in property-damage-only (PDO) and personal injury (PI) crashes over the past two years...
April 3, 2018: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29625095/predictive-validity-of-the-start-back-tool-for-risk-of-persistent-disabling-back-pain-in-a-united-states-primary-care-setting
#19
Pradeep Suri, Kristin Delaney, Sean D Rundell, Daniel C Cherkin
OBJECTIVE: To examine the predictive validity of the STarT Back tool for classifying people with back pain into categories of low, medium, and high risk of persistent disabling back pain, in US primary care. DESIGN: Secondary analysis of data from participants receiving usual care in a randomized clinical trial. SETTING: Primary care clinics. PARTICIPANTS: 1109 adults with back pain ≥18 years of age. Those with specific causes of back pain (pregnancy, disc herniation, vertebral fracture, spinal stenosis) and work-related injuries were not included...
April 3, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29624450/national-athletic-trainers-association-position-statement-evaluation-management-and-outcomes-of-and-return-to-play-criteria-for-overhead-athletes-with-superior-labral-anterior-posterior-injuries
#20
Lori A Michener, Jeffrey S Abrams, Kellie C Huxel Bliven, Sue Falsone, Kevin G Laudner, Edward G McFarland, James E Tibone, Charles A Thigpen, Timothy L Uhl
OBJECTIVE:   To present recommendations for the diagnosis, management, outcomes, and return to play of athletes with superior labral anterior-posterior (SLAP) injuries. BACKGROUND:   In overhead athletes, SLAP tears are common as either acute or chronic injuries. The clinical guidelines presented here were developed based on a systematic review of the current evidence and the consensus of the writing panel. Clinicians can use these guidelines to inform decision making regarding the diagnosis, acute and long-term conservative and surgical treatment, and expected outcomes of and return-to-play guidelines for athletes with SLAP injuries...
March 2018: Journal of Athletic Training
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