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Ming Zhong, Yan-Hong Wang, Lu Wang, Rui-Qing Long, Chun-Lin Chen
A novel type of magnetic molecularly imprinted polymers was prepared for the selective enrichment and isolation of chelerythrine from Macleaya cordata (Willd) R. Br.. The magnetic molecularly imprinted polymers were prepared using functional Fe3 O4 @SiO2 as a magnetic support, chelerythrine as template, methacrylic acid as functional monomer, and ethylene glycol dimethacrylate as cross-linker. Density functional theory at the B3LYP/6-31G (d, p) level with Gaussian 09 software was applied to calculate the interaction energies of chelerythrine, methacrylic acid and the complexes formed from chelerythrine and methacrylic acid in different ratios...
June 19, 2018: Journal of Separation Science
Youjun Zhang, Alisdair R Fernie
The tricarboxylic acid (TCA) cycle is one of the canonical energy pathways of living systems, as well as being an example of a pathway in which dynamic enzyme assemblies, or metabolons, are well characterized. The role of the enzymes have been the subject of saturated transgenesis approaches, whereby the expression of the constituent enzymes were reduced or knocked out in order to ascertain their in vivo function. Some of the resultant plants exhibited improved photosynthesis and plant growth, under controlled greenhouse conditions...
June 19, 2018: Journal of Integrative Plant Biology
Ashish Dhir
Curcumin, a principal curcuminoid present in turmeric, has an antioxidant, anti-inflammatory and neuroprotective properties. Preclinical studies have indicated its beneficial effect for the treatment of epilepsy disorders. The molecule has an anti-seizure potential in preclinical studies, including chemical and electrical models of acute and chronic epilepsy. Curcumin also possesses an anti-epileptogenic activity as it reduces spontaneous recurrent seizures severity in a kainate model of temporal lobe epilepsy...
June 19, 2018: Phytotherapy Research: PTR
Kate L Wegener, Amy E McGrath, Nicholas E Dixon, Aaron J Oakley, Denis B Scanlon, Andrew D Abell, John Bruning
The human sliding clamp (PCNA) controls access to DNA for many proteins involved in DNA replication and repair. Proteins are recruited to the PCNA surface by means of a short, conserved peptide motif known as the PCNA-interacting protein box (PIP-box). Inhibitors of these essential protein-protein interactions may be useful as cancer therapeutics by disrupting DNA replication and repair in these highly proliferative cells. PIP-box peptide mimetics have been identified as a potentially rapid route to potent PCNA inhibitors...
June 19, 2018: Chemistry: a European Journal
Xiaoqing Liu, Suzhen Li, Wenzhu Yang, Bona Mu, Yong Jiao, Xiaojin Zhou, Chunyi Zhang, Yunliu Fan, Rumei Chen
Tissue-specific promoters play an important role in plant molecular farming. Here, we describe a strategy to modify the tissue specificity of a maize embryo-specific bidirectional promoter PZmBD1. Six types of cis elements: RY repeats (R), GCN4 (G), the prolamin box (P), Skn-1 (S), and the ACGT and AACA (A) motifs, were collected and fused to PZmBD1 to generate eight chimeric putative bidirectional promoters. Qualitative and quantitative analysis of reporter genes driven by the promoters showed that two promoters exhibited high seed-specific bidirectional activity in maize transient and stable transformed system...
June 15, 2018: Plant & Cell Physiology
Zhongwen Zhou, Ning Cui, Shuai Su, Shuhong Sun, Zhizhong Cui
Integration of retro-viral long terminal repeat (LTR) into the Marek's disease virus (MDV) genome can occur both in co-cultivation cell cultures and naturally in dual infected chickens. It is clear that the LTR insert is associated with the pathogenicity of MDV. The objective of this study was to compare the host responses to MDV with a different retro-viral LTR insert. Gene-chip containing chicken genome was employed to investigate the gene transcription profile of chicken embryo fibroblasts cells, and 795 genes were differentially expressed in chicken embryo fibroblasts infected with GX0101 with a reticuloendotheliosis virus LTR insert as compared to GX0101-ALV-LTR significantly...
June 16, 2018: Poultry Science
Kirsten Lochbuehler, E Paul Wileyto, Melissa Mercincavage, Valentina Souprountchouk, Jordan Z Burdge, Kathy Z Tang, Joseph N Cappella, Andrew A Strasser
Objectives: Recent research has shown that message congruency is beneficial to recall of pictorial health warning label (PWL) content after initial exposure. Despite less attention to the text warning, smokers exposed to congruent PWLs were more likely to recall the text and the message. This study aimed to replicate these findings and to examine whether congruency also affects recall after multiple exposures over time. Methods: 320 daily smokers (39.7% female; cigarettes/day: M = 15...
June 16, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
Paulo César de Faccio Carvalho, Caitlin Adair Peterson, Pedro Arthur de Albuquerque Nunes, Amanda Posselt Martins, William de Souzsa Filho, Vanessa Thoma Bertolazi, Taíse Robinson Kunrath, Aníbal de Moraes, Ibanor Anghinoni
Sustainable intensification of land-use practices has never been more important to ensure food security for a growing world population. When combined under thoughtful management, cover cropping and crop-livestock integration under no-till systems can benefit from unexpected synergies due to their unique features of plant-animal diversification and complex agroecosystem functions. Mimicking the nutrient coupling/decoupling processes of natural ecosystems by diversifying plant and animal components of no-till integrated crop-livestock operations is an essential feature of the design of agroecological systems that support self-regulating feedbacks and lend resilience while increasing productivity and ecosystem service provision...
June 16, 2018: Journal of Animal Science
Peter M Richardson, Andrew J Parrott, Olga Semenova, Alison Nordon, Simon B Duckett, Meghan E Halse
Benchtop NMR spectrometers operating with low magnetic fields of 1-2 T at sub-ppm resolution show great promise as analytical platforms that can be used outside the traditional laboratory environment for industrial process monitoring. One current limitation that reduces the uptake of benchtop NMR is associated with the detection fields' reduced sensitivity. Here we demonstrate how para-hydrogen (p-H2) based signal amplification by reversible exchange (SABRE), a simple to achieve hyperpolarization technique, enhances agent detectability within the environment of a benchtop (1 T) NMR spectrometer so that informative 1H and 13C NMR spectra can be readily recorded for low-concentration analytes...
June 19, 2018: Analyst
Ramon Sanchez-Ocana, Irene Penas-Herrero, Paula Gil-Simon, Carlos de la Serna-Higuera, Manuel Perez-Miranda
No abstract text is available yet for this article.
December 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Guiomar Niso, Krzysztof J Gorgolewski, Elizabeth Bock, Teon L Brooks, Guillaume Flandin, Alexandre Gramfort, Richard N Henson, Mainak Jas, Vladimir Litvak, Jeremy T Moreau, Robert Oostenveld, Jan-Mathijs Schoffelen, Francois Tadel, Joseph Wexler, Sylvain Baillet
We present a significant extension of the Brain Imaging Data Structure (BIDS) to support the specific aspects of magnetoencephalography (MEG) data. MEG measures brain activity with millisecond temporal resolution and unique source imaging capabilities. So far, BIDS was a solution to organise magnetic resonance imaging (MRI) data. The nature and acquisition parameters of MRI and MEG data are strongly dissimilar. Although there is no standard data format for MEG, we propose MEG-BIDS as a principled solution to store, organise, process and share the multidimensional data volumes produced by the modality...
June 19, 2018: Scientific Data
Callum J Court, Jacqueline M Cole
Large auto-generated databases of magnetic materials properties have the potential for great utility in materials science research. This article presents an auto-generated database of 39,822 records containing chemical compounds and their associated Curie and Néel magnetic phase transition temperatures. The database was produced using natural language processing and semi-supervised quaternary relationship extraction, applied to a corpus of 68,078 chemistry and physics articles. Evaluation of the database shows an estimated overall precision of 73%...
June 19, 2018: Scientific Data
Ricardo D Bennun, Eduardo Stefano, Luis E Moggi
: Van der Woude syndrome is the most generic form of syndromic orofacial cleft, present in approximately 2% of all cleft patients. The lower lip pits with or without cleft lip and/or palate is typical of this syndrome. Popliteal pterygium syndrome (PPS), also known as popliteal web syndrome or fasciogenito-popliteal syndrome, was first described by Trelat in 1869, the incidence is approximately 1 in 300,000 live births. The term PPS was coined by Gorlin et al in 1968 based on the most unusual anomaly, the popliteal pterygium...
June 18, 2018: Journal of Craniofacial Surgery
Howard J Osofsky, Carl F Weems, Rebecca A Graham, Joy D Osofsky, Tonya C Hansel, Lucy S King
OBJECTIVE: Theorists and researchers have linked resilience with a host of positive psychological and physical health outcomes. This paper examines perceptions of resilience and physical health symptoms in a sample of individuals exposed to multiple community disasters following involvement in integrated mental health services. METHODS: A multiwave naturalistic design was used to follow 762 adult clinic patients (72% female; 28% minority status), ages 18-92 years (mean age=40 years), who were evaluated for resilience and physical health symptoms prior to receiving services and at 1, 3, and 6 months' follow-up...
June 19, 2018: Disaster Medicine and Public Health Preparedness
Pawel J Matusz, Suzanne Dikker, Alexander G Huth, Catherine Perrodin
Real-world environments are typically dynamic, complex, and multisensory in nature and require the support of top-down attention and memory mechanisms for us to be able to drive a car, make a shopping list, or pour a cup of coffee. Fundamental principles of perception and functional brain organization have been established by research utilizing well-controlled but simplified paradigms with basic stimuli. The last 30 years ushered a revolution in computational power, brain mapping, and signal processing techniques...
June 19, 2018: Journal of Cognitive Neuroscience
Anna Maria Alexandrou, Timo Saarinen, Jan Kujala, Riitta Salmelin
During natural speech perception, listeners must track the global speaking rate, that is, the overall rate of incoming linguistic information, as well as transient, local speaking rate variations occurring within the global speaking rate. Here, we address the hypothesis that this tracking mechanism is achieved through coupling of cortical signals to the amplitude envelope of the perceived acoustic speech signals. Cortical signals were recorded with magnetoencephalography (MEG) while participants perceived spontaneously produced speech stimuli at three global speaking rates (slow, normal/habitual, and fast)...
June 19, 2018: Journal of Cognitive Neuroscience
Kevin A Henry, C Roger MacKenzie
Single-domain antibodies (sdAbs), the autonomous variable domains of heavy chain-only antibodies produced naturally by camelid ungulates and cartilaginous fishes, have evolved to bind antigen using only three complementarity-determining region (CDR) loops rather than the six present in conventional VH :VL antibodies. It has been suggested, based on limited evidence, that sdAbs may adopt paratope structures that predispose them to preferential recognition of recessed protein epitopes, but poor or non-recognition of protuberant epitopes and small molecules...
June 19, 2018: MAbs
Line Ravn Nielsen, Søren Bang Nielsen, Zichen Zhao, Karsten Olsen, Jacob Holm Nielsen, Marianne N Lund
The effect of free cysteine (in different concentrations) on the thermal aggregation of calcium saturated (Ca-sat) and depleted (Ca-dep) α-lactalbumin (α-LA) was investigated at 25 °C, 50 °C, and 70 °C. The temperatures were chosen to be below denaturation temperature (Td) of Ca-dep and Ca-sat α-LA (25 °C), above Td of Ca-dep α-LA and below that of Ca-sat α-LA (50 °C), and above Td of Ca-sat α-LA (70 °C). Size exclusion chromatography coupled to multi-angle light scattering showed that no or only minor aggregation was obtained at the investigated temperatures for both Ca-dep and Ca-sat α-LA even at extended holding times...
June 19, 2018: Journal of Agricultural and Food Chemistry
Lauren E Marbella, Matthew L Evans, Matthias F Groh, Joseph Nelson, Kent J Griffith, Andrew J Morris, Clare P Grey
Na-ion batteries are promising alternatives to Li-ion systems for electrochemical energy storage because of the higher natural abundance and widespread distribution of Na compared to Li. High capacity anode materials, such as phosphorus, have been explored to realize Na-ion battery technologies that offer comparable performances to their Li-ion counterparts. While P anodes provide unparalleled capacities, the mechanism of sodiation and desodiation is not well-understood, limiting further optimization. Here, we use a combined experimental and theoretical approach to provide molecular-level insight into the (de)sodiation pathways in black P anodes for sodium-ion batteries...
June 19, 2018: Journal of the American Chemical Society
Arjan Geersing, Nathalie Ségaud, Monique G P van der Wijst, Marianne G Rots, Gerard Roelfes
Metal coordination complexes can display interesting biological activity, as illustrated by the bleomycins (BLMs), a family of natural antibiotics that when coordinated to a redox-active metal ion, show antitumor activity. Yet, which metal ion is required for the activity in cells is still subject to debate. In this study, we described how different metal ions affect the intracellular behavior and activity of the synthetic BLM-mimic N, N-bis(2-pyridylmethyl)- N-bis(2-pyridyl)methylamine (N4Py). Our study shows that a mixture of iron(II), copper(II), and zinc(II) complexes can be generated when N4Py is added to cell cultures but that the metal ion can also be exchanged by other metal ions present in cells...
June 19, 2018: Inorganic Chemistry
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