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https://www.readbyqxmd.com/read/28060892/the-utility-of-post-void-residual-volume-versus-sphincter-electromyography-to-distinguish-between-multiple-system-atrophy-and-parkinson-s-disease
#1
Tatsuya Yamamoto, Masato Asahina, Yoshitaka Yamanaka, Tomoyuki Uchiyama, Shigeki Hirano, Miki Fuse, Yasuko Koga, Ryuji Sakakibara, Satoshi Kuwabara
OBJECTIVE: To determine the ability of sphincter electromyography (EMG) and post-void residual urine volume (PVR) during a free-flow study and a pressure-flow study (PFS) for distinguishing multiple system atrophy (MSA) from Parkinson's disease (PD). METHODS: We retrospectively reviewed 241 case records; both urodynamic study and sphincter EMG were performed in patients with MSA (n = 147) and PD (n = 94). RESULTS: There was a statistically significant difference (p < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28057078/determinates-of-muscle-precursor-cell-therapy-efficacy-in-a-nonhuman-primate-model-of-intrinsic-urinary-sphincter-deficiency
#2
James Koudy Williams, Ashley Dean, Shannon Lankford, Tracy Criswell, Gopal Badlani, Karl-Erik Andersson
BACKGROUND: Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinates of cell efficacy in the different patient cohorts. We have reported that in nonhuman primates the chronicity of ISD may affect cell efficacy, but additional factors (age, psychosocial stress, hormone status, body weight) can be associated with many disease/treatment outcomes in women - and these factors are the focus of this study...
January 6, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28052277/unknown-primary-melanoma-worldwide-survey-on-clinical-management
#3
Simone Ribero, Riccardo Pampena, Veronique Bataille, Elvira Moscarella, Luc Thomas, Pietro Quaglino, Concetta Potenza, Alexander C J Van Akkooi, Alessandro Testori, Paul Nathan, Susana Puig, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
BACKGROUND: How to deal with melanoma of unknown primary (MUP) origin is a debated topic in the literature. OBJECTIVE: We performed a worldwide survey to inquire what clinical and investigational workup is performed as well as the physicians' perception of this disease. METHODS: A questionnaire was sent via mail to clinicians involved in melanoma care from December 2015 to April 2016 using the International Dermoscopy Society website. RESULTS: 119 physicians from 47 different countries answered the questionnaire...
January 5, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28011653/framing-the-policy-debate-over-spirits-excise-tax-in-poland
#4
Mateusz Zatoński, Benjamin Hawkins, Martin McKee
Industry lobbying remains an obstacle to effective health-oriented alcohol policy. In 2013, an increase in excise tax on spirits was announced by the Polish government. This article presents a qualitative analysis of the public debate that ensued on the potential economic, health and social effects of the policy. It focuses on how competing groups, including industry actors, framed their position and sought to dominate the debate. Online archives of five Polish national newspapers, two spirits trade associations, and parliamentary and ministerial archives were searched...
December 23, 2016: Health Promotion International
https://www.readbyqxmd.com/read/28003283/clinical-practitioners-views-on-the-management-of-patients-with-medically-unexplained-physical-symptoms-mups-a-qualitative-study
#5
A Keith W Brownell, Chloe Atkins, Andrea Whiteley, Robert F Woollard, Jude Kornelsen
OBJECTIVES: By identifying strategies that practicing physicians use in managing patients with medically unexplained physical symptoms (MUPS), we present an interim practical management guide (IPMG) that clinical practitioners may find useful in their clinical practices and that may help guide future research. DESIGN: A qualitative research study based on interview data from practicing physicians with experience in dealing with MUPS and known to the physician members of the research team...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27997686/electrophysiological-and-neuromuscular-stability-of-persons-with-chronic-inflammatory-demyelinating-polyneuropathy-cidp
#6
Kevin J Gilmore, Matti D Allen, Timothy J Doherty, Kurt Kimpinski, Charles L Rice
OBJECTIVE: We assessed motor unit (MU) properties and neuromuscular stability in the tibialis anterior (TA) of CIDP patients using decomposition-based quantitative electromyography (DQEMG). METHODS: Dorsiflexion strength was assessed, and surface and concentric needle electromyography (EMG) were sampled from the TA. Estimates of MU numbers were derived using DQEMG and spike-triggered averaging. Neuromuscular transmission stability was assessed from concentric needle-detected motor unit potentials (MUPs)...
December 20, 2016: Muscle & Nerve
https://www.readbyqxmd.com/read/27922085/diversity-of-major-urinary-proteins-mups-in-wild-house-mice
#7
Michaela Thoß, Viktoria Enk, Hans Yu, Ingrid Miller, Kenneth C Luzynski, Boglarka Balint, Steve Smith, Ebrahim Razzazi-Fazeli, Dustin J Penn
Major urinary proteins (MUPs) are often suggested to be highly polymorphic, and thereby provide unique chemical signatures used for individual and genetic kin recognition; however, studies on MUP variability have been lacking. We surveyed populations of wild house mice (Mus musculus musculus), and examined variation of MUP genes and proteins. We sequenced several Mup genes (9 to 11 loci) and unexpectedly found no inter-individual variation. We also found that microsatellite markers inside the MUP cluster show remarkably low levels of allelic diversity, and significantly lower than the diversity of markers flanking the cluster or other markers in the genome...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27891518/size-and-proportions-of-slow-twitch-and-fast-twitch-muscle-fibers-in-human-costal-diaphragm
#8
Marija Meznaric, Erika Cvetko
Smaller diaphragmatic motor unit potentials (MUPs) compared to MUPs of limb muscles lead to the hypothesis that diaphragmatic muscle fibers, being the generators of MUPs, might be also smaller. We compared autopsy samples of costal diaphragm and vastus lateralis of healthy men with respect to fibers' size and expression of slow myosin heavy chain isoform (MyHC-1) and fast 2A isoform (MyHC-2A). Diaphragmatic fibers were smaller than fibers in vastus lateralis with regard to the mean minimal fiber diameter of slow-twitch (46...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27829664/minimum-alcohol-pricing-policies-in-practice-a-critical-examination-of-implementation-in-canada
#9
Kara Thompson, Tim Stockwell, Ashley Wettlaufer, Norman Giesbrecht, Gerald Thomas
There is an interest globally in using Minimum Unit Pricing (MUP) of alcohol to promote public health. Canada is the only country to have both implemented and evaluated some forms of minimum alcohol prices, albeit in ways that fall short of MUP. To inform these international debates, we describe the degree to which minimum alcohol prices in Canada meet recommended criteria for being an effective public health policy. We collected data on the implementation of minimum pricing with respect to (1) breadth of application, (2) indexation to inflation and (3) adjustments for alcohol content...
November 9, 2016: Journal of Public Health Policy
https://www.readbyqxmd.com/read/27717380/local-versus-intravenous-injections-of-skeletal-muscle-precursor-cells-in-nonhuman-primates-with-acute-or-chronic-intrinsic-urinary-sphincter-deficiency
#10
J Koudy Williams, Gopal Badlani, Ashley Dean, Shannon Lankford, Kimberly Poppante, Tracy Criswell, Karl-Erik Andersson
BACKGROUND: Many factors may influence the efficacy of cell therapy for intrinsic urinary sphincter deficiency (ISD), including the route of administration of the cells and the condition of the sphincter. The goal of this study was to compare local versus intravenous administration of autologous skeletal muscle precursor cells (skMPCs) when administered to nonhuman primates (NHPs) with either acute or chronic ISD. METHODS: Thirty-two adult female monkeys were divided into eight groups (n = 4/group): (1) control; (2) surgically induced ISD/no treatment; (3) acute ISD (6-week duration)/local vehicle only; (4) acute ISD/local skMPC injection; (5) acute ISD/systemic skMPC; (6) chronic ISD (6-month duration)/local vehicle; (7) chronic ISD/local skMPC; (8) chronic ISD/systemic skMPC...
October 7, 2016: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/27702695/multispectral-uv-imaging-for-surface-analysis-of-mups-tablets-with-special-focus-on-the-pellet-distribution
#11
Anna Novikova, Jens M Carstensen, Thomas Rades, Prof Dr Claudia S Leopold
In the present study the applicability of multispectral UV imaging in combination with multivariate image analysis for surface evaluation of MUPS tablets was investigated with respect to the differentiation of the API pellets from the excipients matrix, estimation of the drug content as well as pellet distribution, and influence of the coating material and tablet thickness on the predictive model. Different formulations consisting of coated drug pellets with two coating polymers (Aquacoat(®) ECD and Eudragit(®) NE 30 D) at three coating levels each were compressed to MUPS tablets with various amounts of coated pellets and different tablet thicknesses...
December 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27694526/motor-unit-number-estimates-and-neuromuscular-transmission-in-the-tibialis-anterior-of-master-athletes-evidence-that-athletic-older-people-are-not-spared-from-age-related-motor-unit-remodeling
#12
Mathew Piasecki, Alex Ireland, Jessica Coulson, Dan W Stashuk, Andrew Hamilton-Wright, Agnieszka Swiecicka, Martin K Rutter, Jamie S McPhee, David A Jones
Muscle motor unit numbers decrease markedly in old age, while remaining motor units are enlarged and can have reduced neuromuscular junction transmission stability. However, it is possible that regular intense physical activity throughout life can attenuate this remodeling. The aim of this study was to compare the number, size, and neuromuscular junction transmission stability of tibialis anterior (TA) motor units in healthy young and older men with those of exceptionally active master runners. The distribution of motor unit potential (MUP) size was determined from intramuscular electromyographic signals recorded in healthy male Young (mean ± SD, 26 ± 5 years), Old (71 ± 4 years) and Master Athletes (69 ± 3 years)...
October 2016: Physiological Reports
https://www.readbyqxmd.com/read/27666879/-needle-electromyography-features-and-values-of-paraspinal-muscle-parameters-in-assessment-of-respiratory-function-of-patients-with-amyotrophic-lateral-sclerosis
#13
Y T Ren, F Cui, F Yang, Z H Chen, L Ling, X S Huang
Objective: To analyze the features of needle electromyography (EMG) in patients with amyotrophic lateral sclerosis (ALS), and explore the correlation between EMG parameters of the tenth thoracic paraspinal muscle and disease duration, rate of disease progression, forced vital capacity (FVC) and revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R). Methods: Standard EMG was recorded from unilateral sternocleidomastoid muscle and/or tongue muscles, upper and lower limbs muscles and the tenth thoracic paraspinal muscle in 112 patients with definite ALS between March 2012 and June 2013 in the Department of Neurology at Chinese PLA General Hospital...
September 6, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27619359/marginal-ulcer-perforation-a-single-center-experience
#14
S K Natarajan, D Chua, K Anbalakan, V G Shelat
PURPOSE: Marginal ulcer (MU) is defined as ulcer on the jejunal side of the gastrojejunostomy (GJ) anastomosis. Most MUs are managed medically but those with complications like bleeding or perforation require intervention. It is recommended that GJ anastomosis be revised in patients with MU perforation (MUP). The aim of this case series is to study the clinical presentation and management of MUP. METHODS: Three hundred and thirty-two patients who underwent emergency surgery for perforated peptic ulcer at a single center were studied over a period of 5 years...
September 12, 2016: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/27609766/a-qualitative-analysis-of-explanatory-models-in-medically-unexplained-physical-symptoms-presenting-to-a-tertiary-health-care-psychiatric-facility-in-south-india
#15
Vikas Menon, Balasubramanian Shanmuganathan, Anand Babu Arun, Jaiganesh Selvapandian Thamizh, Nivedhitha Selvakumar, Siddharth Sarkar
BACKGROUND: Knowledge about subjective perceptions and explanatory models has the potential to inform clinical evaluation and lead to development of patient-friendly treatment models in medically unexplained physical symptoms (MUPS). AIM: To collect qualitative data about explanatory models in MUPS. METHODS: A cross-sectional observational study was done among patients with MUPS presenting over a 2-year period to a specialty psychosomatic clinic...
September 8, 2016: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/27577013/on-the-saliva-proteome-of-the-eastern-european-house-mouse-mus-musculus-musculus-focusing-on-sexual-signalling-and-immunity
#16
Pavel Stopka, Barbora Kuntová, Petr Klempt, Leona Havrdová, Martina Černá, Romana Stopková
Chemical communication is mediated by sex-biased signals abundantly present in the urine, saliva and tears. Because most studies concentrated on the urinary signals, we aimed to determine the saliva proteome in wild Mus musculus musculus, to extend the knowledge on potential roles of saliva in chemical communication. We performed the gel-free quantitative LC-MS/MS analyses of saliva and identified 633 proteins with 134 (21%) of them being sexually dimorphic. They include proteins that protect and transport volatile organic compounds in their beta barrel including LCN lipocalins, major urinary proteins (MUPs), and odorant binding proteins (OBPs)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27567139/influence-of-timing-variability-between-motor-unit-potentials-on-m-wave-characteristics
#17
Javier Rodriguez-Falces, Armando Malanda, Iban Latasa, Ana Lavilla-Oiz, Javier Navallas
The transient enlargement of the compound muscle action potential (M wave) after a conditioning contraction is referred to as potentiation. It has been recently shown that the potentiation of the first and second phases of a monopolar M wave differed drastically; namely, the first phase remained largely unchanged, whereas the second phase underwent a marked enlargement and shortening. This dissimilar potentiation of the first and second phases has been suggested to be attributed to a transient increase in conduction velocity after the contraction...
October 2016: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/27542987/potential-impact-of-minimum-unit-pricing-for-alcohol-in-ireland-evidence-from-the-national-alcohol-diary-survey
#18
Gráinne Cousins, Deirdre Mongan, Joe Barry, Bobby Smyth, Marion Rackard, Jean Long
AIM: One of the main provisions of the Irish Public Health (Alcohol) Bill is the introduction of a minimum unit price (MUP) for alcohol in Ireland, set at €1.00/standard drink. We sought to identify who will be most affected by the introduction of a MUP, examining the relationship between harmful alcohol consumption, personal income, place of purchase and price paid for alcohol. METHOD: A nationally representative survey of 3187 respondents aged 18-75 years, completing a diary of their previous week's alcohol consumption...
November 2016: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/27519162/the-allergen-mus-m-1-0102-dissecting-the-relationship-between-molecular-conformation-and-allergenic-potency
#19
Elena Ferrari, Emanuela Casali, Samuele E Burastero, Alberto Spisni, Thelma A Pertinhez
BACKGROUND: The species Mus musculus experiences an obligate proteinuria: predominant are the Major Urinary Proteins (MUPs), that, collectively known as the major mouse allergen Mus m 1, are among the most important aeroallergens for mouse allergic patients. The production of a soluble and stable hypoallergenic form of Mus m 1 is essential for the development of immunotherapeutic protocols to treat allergic symptoms. METHODS: We introduced the substitution C138S in recombinant Mus m 1...
November 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27464909/regulation-of-highly-homologous-major-urinary-proteins-in-house-mice-quantified-with-label-free-proteomic-methods
#20
Viktoria M Enk, Christian Baumann, Michaela Thoß, Kenneth C Luzynski, Ebrahim Razzazi-Fazeli, Dustin J Penn
Major urinary proteins (MUPs) are highly homologous proteoforms that function in binding, transporting and releasing pheromones in house mice. The main analytical challenge for studying variation in MUPs, even for state-of-the-art proteomics techniques, is their high degree of amino acid sequence homology. In this study we used unique peptides for proteoform-specific identification. We applied different search engines (ProteinPilot™vs. PEAKS®) and protein databases (MUP database vs. SwissProt + unreviewed MUPs), and found that proteoform identification is influenced by addressing background proteins (unregulated urinary proteins, non-MUPs) during the database search...
October 20, 2016: Molecular BioSystems
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