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https://www.readbyqxmd.com/read/28385522/transcriptome-analysis-of-the-effects-of-chitosan-on-the-hyperlipidemia-and-oxidative-stress-in-high-fat-diet-fed-mice
#1
Bin Wang, Sicong Zhang, Xiaoya Wang, Shuo Yang, Qixing Jiang, Yanshun Xu, Wenshui Xia
Transcriptome analysis was performed to investigate the alterations in gene expression after chitosan (CS) treatment on the liver of mice fed with high-fat diet (HFD). The results showed that the body weight, the liver weight and the epididymal fat mass of HFD mice, which were 62.98%, 46.51% and 239.37%, respectively, higher than those of control mice, could be significantly decreased by chitosan supplementation. Also, high-fat diet increased both plasma lipid and liver lipid as compared with the control mice...
April 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28367086/characterization-of-the-serum-and-liver-proteomes-in-gut-microbiota-lacking-mice
#2
Yu-Tang Tung, Ying-Ju Chen, Hsiao-Li Chuang, Wen-Ching Huang, Chun-Tsung Lo, Chen-Chung Liao, Chi-Chang Huang
Current nutrition research is focusing on health promotion, disease prevention, and performance improvement for individuals and communities around the world. The humans with required nutritional ingredients depend on both how well the individual is provided with balanced foods and what state of gut microbiota the host has. Studying the mutually beneficial relationships between gut microbiome and host is an increasing attention in biomedical science. The purpose of this study is to understand the role of gut microbiota and to study interactions between gut microbiota and host...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28360994/mrsa-decolonization-failure-are-biofilms-the-missing-link
#3
Frank Günther, Brigitte Blessing, Evelina Tacconelli, Nico T Mutters
BACKGROUND: Device-associated infections due to biofilm-producing methicillin-resistant Staphylococcus aureus (MRSA) have been recently associated with the failure of antibiotic treatment and decolonization measures. The goal of our study was to evaluate the extent to which the formation of biofilms influenced the efficacy of topical decolonization agents or disinfectants such as mupirocin (MUP), octenidine (OCT), chlorhexidine (CHG), polyhexanide (POL), and chloroxylenol (CLO). METHODS: Bacterial killing in biofilms by the disinfectants and MUP was determined as the reduction [%] in metabolic activity determined by a biofilm viability assay that uses kinetic analysis of metabolic activity...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28337988/molecular-heterogeneity-in-major-urinary-proteins-of-mus-musculus-subspecies-potential-candidates-involved-in-speciation
#4
Jane L Hurst, Robert J Beynon, Stuart D Armstrong, Amanda J Davidson, Sarah A Roberts, Guadalupe Gómez-Baena, Carole M Smadja, Guila Ganem
When hybridisation carries a cost, natural selection is predicted to favour evolution of traits that allow assortative mating (reinforcement). Incipient speciation between the two European house mouse subspecies, Mus musculus domesticus and M.m.musculus, sharing a hybrid zone, provides an opportunity to understand evolution of assortative mating at a molecular level. Mouse urine odours allow subspecific mate discrimination, with assortative preferences evident in the hybrid zone but not in allopatry. Here we assess the potential of MUPs (major urinary proteins) as candidates for signal divergence by comparing MUP expression in urine samples from the Danish hybrid zone border (contact) and from allopatric populations...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28331142/usefulness-of-color-coding-resected-samples-from-a-pancreaticoduodenectomy-with-tissue-marking-dyes-for-a-detailed-examination-of-surgical-margin-surrounding-the-uncinate-process-of-the-pancreas
#5
Satoshi Mizutani, Hideyuki Suzuki, Takayuki Aimoto, Seiji Yamagishi, Keisuke Mishima, Masanori Watanabe, Yasuhiko Kitayama, Norio Motoda, Saiko Isshiki, Eiji Uchida
BACKGROUND: Characteristics of a cancer-positive margin around a resected uncinate process of the pancreas (MUP) due to a pancreticoduodenectomy are difficult to understand by standardized evaluation because of its complex anatomy. The purposes of this study were to subclassify the MUP with tissue marking dyes of different colors and to identify the characteristics of sites that showed positivity for cancer cells in patients with pancreatic head carcinoma who underwent circumferential superior mesenteric arterial nerve plexus-preserving pancreaticoduodenectomy...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
https://www.readbyqxmd.com/read/28325700/the-relationship-between-preoperative-needle-electromyography-findings-and-muscle-power-restoration-after-surgery-in-severe-carpal-tunnel-syndrome-patients
#6
Yuki Hara, Yasumasa Nishiura, Naoyuki Ochiai, Shinji Murai, Masashi Yamazaki
PURPOSE: Needle electromyography provides essential information about the functional aspects of the muscle. But little attention has been given in the literature to needle electromyography examinations in carpal tunnel syndrome. We examined the relationship between preoperative needle electromyography findings and functional recovery of the abductor pollicis brevis (APB) muscle in severe carpal tunnel syndrome patients. METHODS: The subjects of this study were 49 patients, 58 hands, who fit the following 5 criteria: (1) idiopathic carpal tunnel syndrome; (2) pre-op MMT grade of the APB muscle was M0 or M1; (3) APB-CMAP (compound muscle action potential) was not evoked in a median nerve conduction study; (4) needle electromyography of the APB muscle had been done; (5) underwent carpal tunnel release only...
March 18, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28295128/medically-unexplained-physical-symptoms-mups-among-adults-in-canada-comorbidity-health-care-use-and-employment
#7
Jungwee Park, Heather Gilmour
Based on data from the 2014 Canadian Community Health Survey and the 2012 Canadian Community Health Survey-Mental Health, this study provides estimates of the prevalence of medically unexplained physical symptoms (MUPS) in the household population aged 25 or older. MUPS are examined in relation to sociodemographic characteristics, physical and mental comorbidity, health care use and unmet needs, labour force participation and productivity. In 2014, 5.5% of Canadian adults-an estimated 1.3 million - reported having chronic fatigue syndrome (1...
March 15, 2017: Health Reports
https://www.readbyqxmd.com/read/28293469/motor-unit-potentials-of-the-erector-spinae-muscle-by-concentric-needle-electromyography
#8
Andreas Posa, Izabela Niśkiewicz, Alexander Emmer, Yorck Kluge, Malte E Kornhuber
INTRODUCTION: The needle electromyography (EMG) serves to supply additional information in patients with suspected neuromuscular disorders. We aimed to provide motor unit potential (MUP) data by concentric needle EMG in the erector spinae (ES) in comparison with biceps brachii (BB) and lateral vastus (LV). METHODS: Electromyography MUP data (n) were obtained in ES (517), BB (539), and LV (627) in 32 healthy volunteers (16f). RESULTS: Motor unit potential data: amplitude (μV) 393 ± 174 (ES), 375 ± 162 (BB), and 577 ± 304 (LV); duration (ms) 10...
March 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28275253/minimum-alcohol-pricing-policies-in-practice-a-critical-examination-of-implementation-in-canada
#9
Kara Thompson, Tim Stockwell, Ashley Wettlaufer, Norman Giesbrecht, Gerald Thomas
There is an interest globally in using Minimum Unit Pricing (MUP) of alcohol to promote public health. Canada is the only country to have both implemented and evaluated some forms of minimum alcohol prices, albeit in ways that fall short of MUP. To inform these international debates, we describe the degree to which minimum alcohol prices in Canada meet recommended criteria for being an effective public health policy. We collected data on the implementation of minimum pricing with respect to (1) breadth of application, (2) indexation to inflation and (3) adjustments for alcohol content...
February 2017: Journal of Public Health Policy
https://www.readbyqxmd.com/read/28258223/zhx2-zinc-fingers-and-homeoboxes-2-regulates-major-urinary-protein-gene-expression-in-the-mouse-liver
#10
Jieyun Jiang, Kate Townsend Creasy, Justin Purnell, Martha L Peterson, Brett T Spear
The mouse major urinary proteins (Mups) are encoded by a large family of highly related genes clustered on chromosome 4. Mups, synthesized primarily and abundantly in the liver and secreted through the kidneys, exhibit male-biased expression. Mups bind a variety of volatile ligands; these ligands, and Mup proteins themselves, influence numerous behavioral traits. Although urinary Mup protein levels vary between inbred mouse strains, this difference is most pronounced in BALB/cJ mice, which have dramatically low urinary Mup levels; this BALB/cJ trait had been mapped to a locus on chromosome 15...
April 21, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28252410/a-density-based-clustering-approach-to-motor-unit-potential-characterizations-to-support-diagnosis-of-neuromuscular-disorders
#11
Tahereh Kamali, Daniel Stashuk
Electrophysiological muscle classification involves characterization of extracted motor unit potentials (MUPs) followed by the aggregation of these MUP characterizations. Existing techniques consider three classes (i.e., myopathic, neurogenic, and normal) for both MUP characterization and electrophysiological muscle classification. However, diseased induced MUP changes are continuous in nature, which make it difficult to find distinct boundaries between normal, myopathic and neurogenic MUPs. Hence, MUP characterization based on more than three classes is better able to represent the various effects of disease...
February 23, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28207399/motor-unit-potential-jitter-a-new-measure-of-neuromuscular-transmission-instability
#12
Meena AbdelMaseeh, Daniel Stashuk
OBJECTIVE: A new measure of neuromuscular transmission instability, motor unit potential (MUP) jitter, is introduced. MUP jitter can be estimated quickly using motor unit potential trains (MUPTs) extracted from electromyographic (EMG) signals acquired using conventional clinical equipment and needle EMG electrodiagnostic protocols. The primary motivation for developing MUP jitter is to avoid the technical demands associated with estimating jitter using conventional single fibre EMG techniques...
February 9, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28169451/an-optimized-transurethral-catheterization-cystometry-in-mice-and-comparison-with-classic-suprapubic-catheterization-cystometry
#13
Zhuoyi Xiang, Yaohui Li, Tingchang Bian, Minke He, Yeqing Xu, Guomin Wang, Jianming Guo, Hang Wang
AIMS: The aim of this study is to establish an optimized, minimally invasive transurethral catheterization cystometry (TUCC) and a novel urethral pressure profile (UPP) measurement for mice. METHODS: The optimized TUCC and the UPP measurement were first established. This optimized TUCC was then performed in 16 anesthetized female mice and compared with the suprapubic catheterization cystometry (SCC) in parallel after suprapubic catheters implantation (SCI; on zero, third, and seventh day, respectively)...
February 7, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28169124/-therapeutic-mega-ureter-primitive-before-one-year-of-life-retrospective-study-of-20years
#14
B Picart, M Pons, A Line, C François, M-L Poli Merol
INTRODUCTION: What is the proper way to manage complicated primary mega-ureter in infants under the age of one. This has already been discussed in the literature but the controversy remains. OBJECTIVE: Evaluate the long-term results of the management of mega-ureter based support under the age of one. MATERIAL AND METHODS: Single-center retrospective study from 1990 to 2010. All children under one year found were evaluated including clinical examination, ultrasound, scintigraphy and cystography...
February 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28139067/the-effects-of-graded-levels-of-calorie-restriction-ix-global-metabolomic-screen-reveals-modulation-of-carnitines-sphingolipids-and-bile-acids-in-the-liver-of-c57bl-6-mice
#15
Cara L Green, Sharon E Mitchell, Davina Derous, Yingchun Wang, Luonan Chen, Jing-Dong J Han, Daniel E L Promislow, David Lusseau, Alex Douglas, John R Speakman
Calorie restriction (CR) remains the most robust intervention to extend lifespan and improve health span. Using a global mass spectrometry-based metabolomic approach, we identified 193 metabolites that were significantly differentially expressed (SDE) in the livers of C57BL/6 mice, fed graded levels of CR (10, 20, 30 and 40% CR) compared to mice fed ad libitum for 12 h a day. The differential expression of metabolites also varied with the different feeding groups. Pathway analysis revealed that graded CR had an impact on carnitine synthesis and the carnitine shuttle pathway, sphingosine-1-phosphate (S1P) signalling and methionine metabolism...
January 31, 2017: Aging Cell
https://www.readbyqxmd.com/read/28130620/extranodal-spread-is-associated-with-recurrence-and-poor-survival-in-stage-iii-cutaneous-melanoma-patients
#16
Thomas R Crookes, Richard A Scolyer, Serigne Lo, Martin Drummond, Andrew J Spillane
BACKGROUND: Inconsistent data suggests extranodal spread (ENS) is an adverse prognostic factor in Stage III melanoma patients but it remains contentious. By rigorously matching cohorts, this study sought to clarify associations with recurrence and survival. METHODS: Melanoma patients with lymph node metastases (AJCC Stage III), with or without ENS, sub-classified on the basis of known (MKP) or unknown primary (MUP), were identified from a single institution prospective database...
January 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28122926/negotiating-explanations-doctor-patient-communication-with-patients-with-medically-unexplained-symptoms-a-qualitative-analysis
#17
Madelon den Boeft, Daniëlle Huisman, LaKrista Morton, Peter Lucassen, Johannes C van der Wouden, Marjan J Westerman, Henriëtte E van der Horst, Christopher D Burton
BACKGROUND: Patients with medically unexplained physical symptoms (MUPS) seek explanations for their symptoms, but often find general practitioners (GPs) unable to deliver these. Different methods of explaining MUPS have been proposed. Little is known about how communication evolves around these explanations. OBJECTIVE: To examine the dialogue between GPs and patients related to explanations in a community-based clinic for MUPS. We categorized dialogue types and dialogue outcomes...
February 2017: Family Practice
https://www.readbyqxmd.com/read/28111593/the-role-of-the-sheffield-model-on-the-minimum-unit-pricing-of-alcohol-debate-the-importance-of-a-rhetorical-perspective
#18
Srinivasa Vittal Katikireddi, Shona Hilton, Lyndal Bond
The minimum unit pricing (MUP) alcohol policy debate has been informed by the Sheffield model, a study which predicts impacts of different alcohol pricing policies. This paper explores the Sheffield model's influences on the policy debate by drawing on 36 semi-structured interviews with policy actors who were involved in the policy debate. Although commissioned by policy makers, the model's influence has been far broader than suggested by views of 'rational' policy making. While findings from the Sheffield model have been used in instrumental ways, they have arguably been more important in helping debate competing values underpinning policy goals...
November 2016: Evidence & Policy: a Journal of Research, Debate and Practice
https://www.readbyqxmd.com/read/28060892/the-utility-of-post-void-residual-volume-versus-sphincter-electromyography-to-distinguish-between-multiple-system-atrophy-and-parkinson-s-disease
#19
Tatsuya Yamamoto, Masato Asahina, Yoshitaka Yamanaka, Tomoyuki Uchiyama, Shigeki Hirano, Miki Fuse, Yasuko Koga, Ryuji Sakakibara, Satoshi Kuwabara
OBJECTIVE: To determine the ability of sphincter electromyography (EMG) and post-void residual urine volume (PVR) during a free-flow study and a pressure-flow study (PFS) for distinguishing multiple system atrophy (MSA) from Parkinson's disease (PD). METHODS: We retrospectively reviewed 241 case records; both urodynamic study and sphincter EMG were performed in patients with MSA (n = 147) and PD (n = 94). RESULTS: There was a statistically significant difference (p < 0...
2017: PloS One
https://www.readbyqxmd.com/read/28057078/determinates-of-muscle-precursor-cell-therapy-efficacy-in-a-nonhuman-primate-model-of-intrinsic-urinary-sphincter-deficiency
#20
James Koudy Williams, Ashley Dean, Shannon Lankford, Tracy Criswell, Gopal Badlani, Karl-Erik Andersson
BACKGROUND: Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinates of cell efficacy in the different patient cohorts. We have reported that in nonhuman primates the chronicity of ISD may affect cell efficacy, but additional factors (age, psychosocial stress, hormone status, body weight) can be associated with many disease/treatment outcomes in women - and these factors are the focus of this study...
January 6, 2017: Stem Cell Research & Therapy
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