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https://www.readbyqxmd.com/read/29329053/long-term-safety-area-tracking-lt-sat-with-online-failure-detection-and-recovery-for-robotic-minimally-invasive-surgery
#1
Veronica Penza, Xiaofei Du, Danail Stoyanov, Antonello Forgione, Leonardo S Mattos, Elena De Momi
Despite the benefits introduced by robotic systems in abdominal Minimally Invasive Surgery (MIS), major complications can still affect the outcome of the procedure, such as intra-operative bleeding. One of the causes is attributed to accidental damages to arteries or veins by the surgical tools, and some of the possible risk factors are related to the lack of sub-surface visibilty. Assistive tools guiding the surgical gestures to prevent these kind of injuries would represent a relevant step towards safer clinical procedures...
December 22, 2017: Medical Image Analysis
https://www.readbyqxmd.com/read/29308958/medically-unexplained-physical-symptoms-misunderstood-and-wrongly-treated-a-semiotic-perspective-on-chronic-pain
#2
Kari Irene H Busvold, Hilde Bondevik
Medically unexplained physical symptoms (MUPS) are a significant and increasing health issue in the western world. Chronic pain constitutes a considerable element of these symptoms, and the lack of a biomedical explanation of their cause challenges the clinical encounter. The limitations of biomedicine become evident in these encounters and expose the need for an expanded understanding of body and symptom. Semiotics, as an anti-dualistic meta-theory, closes the gap between natural science and the humanities and views the human body in an evolutionary and existential perspective...
January 8, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29275789/the-2-year-course-of-medically-unexplained-physical-symptoms-mups-in-terms-of-symptom-severity-and-functional-status-results-of-the-prospects-cohort-study
#3
Nikki Claassen-van Dessel, Johannes C van der Wouden, Trynke Hoekstra, Joost Dekker, Henriëtte E van der Horst
OBJECTIVE: We assessed the 2-year course of Medically Unexplained Physical Symptoms (MUPS) in terms of symptom severity, physical functioning and mental functioning. METHODS: We used data of the PROSPECTS cohort study, consisting of 325 MUPS patients from several health care settings. Symptom severity (PHQ-15), physical functioning (RAND 36 PCS) and mental functioning (RAND 36 MCS) were assessed at baseline and 6, 12 and 24 months afterwards. We used Latent Class Growth Modeling (LCGM) to identify different course types, but as clinical usability of results was limited, we also analysed change scores and directions of change...
January 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29270756/transposition-of-branches-of-radial-nerve-innervating-supinator-to-posterior-interosseous-nerve-for-functional-reconstruction-of-finger-and-thumb-extension-in-4-patients-with-middle-and-lower-trunk-root-avulsion-injuries-of-brachial-plexus
#4
Xia Wu, Xiao-Bing Cong, Qi-Shun Huang, Fang-Xin Ai, Yu-Tian Liu, Xiao-Cheng Lu, Jin Li, Yu-Xiong Weng, Zhen-Bing Chen
This study aimed to investigate the reconstruction of the thumb and finger extension function in patients with middle and lower trunk root avulsion injuries of the brachial plexus. From April 2010 to January 2015, we enrolled in this study 4 patients diagnosed with middle and lower trunk root avulsion injuries of the brachial plexus via imaging tests, electrophysiological examinations, and clinical confirmation. Muscular branches of the radial nerve, which innervate the supinator in the forearm, were transposed to the posterior interosseous nerve to reconstruct the thumb and finger extension function...
December 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29244613/kinetics-study-on-recombinant-alkaline-phosphatase-and-correlation-with-the-fluorescent-signal-generated
#5
Vanessa Susini, Veronica Lucia Rossi, Antonio Sanesi, Laurent Drazek
Alkaline phosphatase (AP) (EC 3.1.3.1) is one of the most used enzymes in immunoassays. In VIDAS® assays (bioMérieux, Marcy l'Etoile, France) AP catalyses the hydrolysis of 4-Methylumbelliferyl phosphate (4-MUP) in 4-Methylumbelliferone (4-MU) producing a fluorescent signal. This work introduces an original method of characterization of the kinetics parameter Km, Vmax and Kcat of AP embedded in VIDAS® assays. Assessment of such constants allows us to predict the fluorescent signal generated for given amounts of enzyme and its associated substrate; in the particular case of VIDAS®, it has been estimated that 0...
December 15, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/29223824/correlating-motor-unit-morphology-with-bioelectrical-activity-a-simulation-study
#6
Ewa Zalewska, Irena Hausmanowa-Petrusewicz
OBJECTIVES: The aim was to determine motor unit morphology underpinning the various MUP waveforms using MUP analysis. METHOD: The simulation method is based on the decomposition of MUP into single fiber potentials. Number of fibers, fiber diameters and fiber to electrode distances were determined. The impact of each muscle fiber on the MUP waveform was determined and quantified by its percentage contribution. RESULTS: The origin of the four examined MUPs of distinct waveforms have been explained by showing the histograms of fiber diameters and their distance to the electrode...
November 16, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29222988/medically-unexplained-physical-symptoms-in-patients-attending-a-medical-outpatient-clinic-in-a-tertiary-hospital-in-north-india
#7
Mohit Sharma, Shubh Mohan Singh, Ajit Avasthi, Subhash C Varma, Aman Sharma, Vikas Suri
OBJECTIVE: Medically unexplained physical symptoms (MUPS) are commonly seen across health care settings. Earlier studies have focussed on prevalence, cost-utilization and burden. Data from India is scarce. Patients with persistent MUPS have more impairment and psychological distress. This study was designed to assess psychological morbidity, health anxiety (HA), somatic symptom load, disability, quality of life (QOL) in patients with persistent MUPS presenting to a general medical outpatient service and compare it with patients with medically explained physical symptoms (MEPS)...
December 2, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29216391/prevalence-and-determinants-of-rem-sleep-behavior-disorder-in-the-general-population
#8
José Haba-Rubio, Birgit Frauscher, Pedro Marques-Vidal, Jérôme Toriel, Nadia Tobback, Daniela Andries, Martin Preisig, Peter Vollenweider, Ronald Postuma, Raphaël Heinzer
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography. Methods: Full polysomnographic data from 1997 subjects (age=59±11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD...
December 5, 2017: Sleep
https://www.readbyqxmd.com/read/29191749/design-and-verification-of-halogen-bonding-system-at-the-complex-interface-of-human-fertilization-related-mup-pdz5-domain-with-camk-s-c-terminal-peptide
#9
Juan Wang, Yunjie Guo, Xue Zhang
Calmodulin-dependent protein kinase (CAMK) is physiologically activated in fertilized human oocytes and is involved in the Ca2+ response pathways that link the fertilization calmodulin signal to meiosis resumption and cortical granule exocytosis. The kinase has an unstructured C-terminal tail that can be recognized and bound by the PDZ5 domain of its cognate partner, the multi-PDZ domain protein (MUP). In the current study, we reported a rational biomolecular design of halogen-bonding system at the complex interface of CAMK's C-terminal peptide with MUP PDZ5 domain by using high-level computational approaches...
November 21, 2017: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29094077/quantitative-facial-electromyography-monitoring-after-hypoglossal-facial-jump-nerve-suture
#10
Jan Flasar, Gerd Fabian Volk, Thordis Granitzka, Katharina Geißler, Andrey Irintchev, Thomas Lehmann, Orlando Guntinas-Lichius
Objectives/Hypothesis: The time course of the reinnervation of the paralyzed face after hypoglossal-facial jump nerve suture using electromyography (EMG) was assessed. The relation to the clinical outcome was analyzed. Study Design: Retrospective single-center cohort study. Methods: Reestablishment of motor units was studied by quantitative EMG and motor unit potential (MUP) analysis in 11 patients after hypoglossal-facial jump nerve suture...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29063801/-it%C3%A2-s-incredible-how-much-i%C3%A2-ve-had-to-fight-negotiating-medical-uncertainty-in-clinical-encounters
#11
Olaug S Lian, Catherine Robson
PURPOSE: Clinical encounters related to medically unexplained physical symptoms (MUPS) are associated with high levels of conflict between patients and doctors. Collaborative difficulties are fused by the medical uncertainty that dominates these consultations. The main aim of this study is to explore the interactional dynamics of clinical encounters riddled by medical uncertainty, as experienced by people living with long-term medically unexplained fatigue in Norway. METHOD: A qualitative thematic analysis of written texts from 256 study participants...
2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29056403/a-non-destructive-method-for-quality-control-of-the-pellet-distribution-within-a-mups-tablet-by-terahertz-pulsed-imaging
#12
Anna Novikova, Daniel Markl, J Axel Zeitler, Thomas Rades, Claudia S Leopold
Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform...
January 1, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29054896/metastatic-melanoma-of-unknown-primary-in-the-temporalis-muscle
#13
Marco Dalle Carbonare, Mei Xien Goh, Zainab AlshiekhAli, David Howlett
Melanomas are aggressive cancers that present as cutaneous, mucosal and ocular lesions with the ability to metastasise widely. There are, however, occasions where lesions are found in distant sites such as lymph nodes, viscera and subcutaneous tissues without clinically apparent skin involvement. This is known as metastatic melanoma of unknown primary (MUP). Its presentation in skeletal muscle is rare, and the available literature is sparse. This article presents an 85-year-old woman with a MUP presenting in the right temporalis muscle, which was diagnosed with the aid of the ultrasound-guided core biopsy...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29019116/bulk-freeze-drying-milling-a-versatile-method-of-developing-highly-porous-cushioning-excipients-for-compacted-multiple-unit-pellet-systems-mups
#14
Carin Ru Shan Siow, Paul Wan Sia Heng, Lai Wah Chan
The compaction of multiple-unit pellet system (MUPS) is a challenging process due to the ease of coat damage under high compression pressure, thereby altering drug release rates. To overcome this, cushioning excipients are added to the tablet formulation. Excipients can be processed into pellets/granules and freeze-dried to increase their porosity and cushioning performance. However, successful formation of pellets/granules has specific requirements that limit formulation flexibility. In this study, a novel top-down approach that harnessed bulk freeze-drying milling was explored to avoid the challenges of pelletization/granulation...
October 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29016713/heavy-drinkers-and-the-potential-impact-of-minimum-unit-pricing-no-single-or-simple-effect
#15
J Gill, H Black, R Rush, F O'May, J Chick
Aims: To explore the potential impact of a minimum unit price (MUP: 50 pence per UK unit) on the alcohol consumption of ill Scottish heavy drinkers. Methods: Participants were 639 patients attending alcohol treatment services or admitted to hospital with an alcohol-related condition. From their reported expenditure on alcohol in their index week, and assuming this remained unchanged, we estimated the impact of a MUP (50 ppu) on future consumption. (Around 15% purchased from both the more expensive on-sale outlets (hotels, pubs, bars) and from off-sales (shops and supermarkets)...
September 7, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28991688/postvoid-residual-predicts-the-diagnosis-of-multiple-system-atrophy-in-parkinsonian-syndrome
#16
Tatsuya Yamamoto, Masato Asahina, Yoshitaka Yamanaka, Tomoyuki Uchiyama, Shigeki Hirano, Miki Fuse, Yasuko Koga, Ryuji Sakakibara, Satoshi Kuwabara
OBJECTIVE: It is difficult to differentiate multiple system atrophy (MSA) from Parkinson's disease (PD) at least in the early stage. Urodynamic study (UDS) is useful in differentiating MSA from PD. We aimed to clarify which UDS parameter was useful in differentiating MSA from PD. METHODS: We retrospectively reviewed 273 cases and performed UDS and external anal sphincter electromyography (EAS-EMG) in patients with MSA (n=182) and PD (n=91). We analyzed the utility of UDS parameters, including postvoid residuals (PVR), detrusor overactivity (DO), degree of bladder contraction, and mean duration of motor unit potentials (MUPs) in EAS-EMG, for differentiating MSA from PD...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28981143/effect-of-very-old-age-on-anconeus-motor-unit-loss-and-compensatory-remodelling
#17
Kevin J Gilmore, Eric A Kirk, Timothy J Doherty, Charles L Rice
INTRODUCTION: It is not known how the process of compensatory remodeling through collateral reinnervation continues into very old age (>80 years) or whether there is a limit to effective motor unit (MU) reinnervation. Therefore, we explore electrophysiological properties related to motor unit number estimates (MUNEs) in very old participants (79-90 years of age) compared with young controls (25-29 years of age). METHODS: Decomposition-enhanced spike-triggered averaging was used to collect surface and intramuscular electromyography information from the anconeus to derive a MUNE...
October 5, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28967998/a-triple-salting-out-effect-is-required-for-the-formation-of-ionic-liquid-based-aqueous-multiphase-systems
#18
Helena Passos, Sara H Costa, Ana M Fernandes, Mara G Freire, Robin D Rogers, João A P Coutinho
Novel aqueous multiphase systems (MuPSs) formed by quaternary mixtures composed of cholinium-based ionic liquids (ILs), polymers, inorganic salts, and water are reported herein. The influence of several ILs, polymers, and salts was studied, demonstrating that a triple salting-out is a required phenomenon to prepare MuPSs. The respective phase diagrams and "tie-surfaces" were determined, followed by the evaluation of the effect of temperature. Finally, the remarkable ability of IL-based MuPSs to selectively separate mixtures of textile dyes is shown...
October 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28967063/comparative-study-of-urodynamic-tests-after-ams-800-and-zsi-375-insertion
#19
Thomas Ripert, Jean Pierrevelcin
STUDY DESIGN: Retrospective, non-randomised, single-centre study. OBJECTIVES: Comparative study of urodynamic tests in patients presenting social continence after AMS 800 or ZSI 375 insertion. MATERIALS AND METHODS: Study was open to patients with social continence, implanted with AMS 800 or ZSI 375. Vesical pressure (VP), urethral functional length (FL), maximal urethral pressure (MUP), maximal urethral closure pressure (MUCP), maximal urinary flow rate (Qmax) were registered with standard urodynamic equipment...
September 21, 2017: Urologia
https://www.readbyqxmd.com/read/28931741/major-urinary-protein-levels-are-associated-with-social-status-and-context-in-mouse-social-hierarchies
#20
Won Lee, Amber Khan, James P Curley
We have previously shown that male mice living in groups of 12 males establish and maintain stable linear social hierarchies with each individual having a defined social rank. However, it is not clear which social cues mice use to signal and recognize their relative social status within their hierarchy. In this study, we investigate how individual social status both in pairs and in groups affects the levels of major urinary proteins (MUPs) and specifically MUP20 in urine. We housed groups of adult outbred CD1 male mice in a complex social environment for three weeks and collected urine samples from all individuals repeatedly...
September 27, 2017: Proceedings. Biological Sciences
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