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https://www.readbyqxmd.com/read/29094077/quantitative-facial-electromyography-monitoring-after-hypoglossal-facial-jump-nerve-suture
#1
Jan Flasar, Gerd Fabian Volk, Thordis Granitzka, Katharina Geißler, Andrey Irintchev, Thomas Lehmann, Orlando Guntinas-Lichius
Objectives/Hypothesis: The time course of the reinnervation of the paralyzed face after hypoglossal-facial jump nerve suture using electromyography (EMG) was assessed. The relation to the clinical outcome was analyzed. Study Design: Retrospective single-center cohort study. Methods: Reestablishment of motor units was studied by quantitative EMG and motor unit potential (MUP) analysis in 11 patients after hypoglossal-facial jump nerve suture...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29063801/-it%C3%A2-s-incredible-how-much-i%C3%A2-ve-had-to-fight-negotiating-medical-uncertainty-in-clinical-encounters
#2
Olaug S Lian, Catherine Robson
PURPOSE: Clinical encounters related to medically unexplained physical symptoms (MUPS) are associated with high levels of conflict between patients and doctors. Collaborative difficulties are fused by the medical uncertainty that dominates these consultations. The main aim of this study is to explore the interactional dynamics of clinical encounters riddled by medical uncertainty, as experienced by people living with long-term medically unexplained fatigue in Norway. METHOD: A qualitative thematic analysis of written texts from 256 study participants...
2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/29056403/a-non-destructive-method-for-quality-control-of-the-pellet-distribution-within-a-mups-tablet-by-terahertz-pulsed-imaging
#3
Anna Novikova, Daniel Markl, J Axel Zeitler, Thomas Rades, Claudia S Leopold
Terahertz pulsed imaging (TPI) was applied to analyse the inner structure of multiple unit pellet system (MUPS) tablets. MUPS tablets containing different amounts of theophylline pellets coated with Eudragit® NE 30 D and with microcrystalline cellulose (MCC) as cushioning agent were analysed. The tablets were imaged by TPI and the results were compared to X-ray microtomography. The terahertz pulse beam propagates through the tablets and is back-reflected at the interface between the MCC matrix and the coated pellets within the tablet causing a peak in the terahertz waveform...
October 19, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29054896/metastatic-melanoma-of-unknown-primary-in-the-temporalis-muscle
#4
Marco Dalle Carbonare, Mei Xien Goh, Zainab AlshiekhAli, David Howlett
Melanomas are aggressive cancers that present as cutaneous, mucosal and ocular lesions with the ability to metastasise widely. There are, however, occasions where lesions are found in distant sites such as lymph nodes, viscera and subcutaneous tissues without clinically apparent skin involvement. This is known as metastatic melanoma of unknown primary (MUP). Its presentation in skeletal muscle is rare, and the available literature is sparse. This article presents an 85-year-old woman with a MUP presenting in the right temporalis muscle, which was diagnosed with the aid of the ultrasound-guided core biopsy...
October 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29019116/bulk-freeze-drying-milling-a-versatile-method-of-developing-highly-porous-cushioning-excipients-for-compacted-multiple-unit-pellet-systems-mups
#5
Carin Ru Shan Siow, Paul Wan Sia Heng, Lai Wah Chan
The compaction of multiple-unit pellet system (MUPS) is a challenging process due to the ease of coat damage under high compression pressure, thereby altering drug release rates. To overcome this, cushioning excipients are added to the tablet formulation. Excipients can be processed into pellets/granules and freeze-dried to increase their porosity and cushioning performance. However, successful formation of pellets/granules has specific requirements that limit formulation flexibility. In this study, a novel top-down approach that harnessed bulk freeze-drying milling was explored to avoid the challenges of pelletization/granulation...
October 10, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29016713/heavy-drinkers-and-the-potential-impact-of-minimum-unit-pricing-no-single-or-simple-effect
#6
J Gill, H Black, R Rush, F O'May, J Chick
Aims: To explore the potential impact of a minimum unit price (MUP: 50 pence per UK unit) on the alcohol consumption of ill Scottish heavy drinkers. Methods: Participants were 639 patients attending alcohol treatment services or admitted to hospital with an alcohol-related condition. From their reported expenditure on alcohol in their index week, and assuming this remained unchanged, we estimated the impact of a MUP (50 ppu) on future consumption. (Around 15% purchased from both the more expensive on-sale outlets (hotels, pubs, bars) and from off-sales (shops and supermarkets)...
September 7, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/28991688/postvoid-residual-predicts-the-diagnosis-of-multiple-system-atrophy-in-parkinsonian-syndrome
#7
Tatsuya Yamamoto, Masato Asahina, Yoshitaka Yamanaka, Tomoyuki Uchiyama, Shigeki Hirano, Miki Fuse, Yasuko Koga, Ryuji Sakakibara, Satoshi Kuwabara
OBJECTIVE: It is difficult to differentiate multiple system atrophy (MSA) from Parkinson's disease (PD) at least in the early stage. Urodynamic study (UDS) is useful in differentiating MSA from PD. We aimed to clarify which UDS parameter was useful in differentiating MSA from PD. METHODS: We retrospectively reviewed 273 cases and performed UDS and external anal sphincter electromyography (EAS-EMG) in patients with MSA (n=182) and PD (n=91). We analyzed the utility of UDS parameters, including postvoid residuals (PVR), detrusor overactivity (DO), degree of bladder contraction, and mean duration of motor unit potentials (MUPs) in EAS-EMG, for differentiating MSA from PD...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28981143/effect-of-very-old-age-on-anconeus-motor-unit-loss-and-compensatory-remodelling
#8
Kevin J Gilmore, Eric A Kirk, Timothy J Doherty, Charles L Rice
INTRODUCTION: It is not known how the process of compensatory remodeling through collateral reinnervation continues into very old age (>80 years) or whether there is a limit to effective motor unit (MU) reinnervation. Therefore, we explore electrophysiological properties related to motor unit number estimates (MUNEs) in very old participants (79-90 years of age) compared with young controls (25-29 years of age). METHODS: Decomposition-enhanced spike-triggered averaging was used to collect surface and intramuscular electromyography information from the anconeus to derive a MUNE...
October 5, 2017: Muscle & Nerve
https://www.readbyqxmd.com/read/28967998/a-triple-salting-out-effect-is-required-for-the-formation-of-ionic-liquid-based-aqueous-multiphase-systems
#9
Helena Passos, Sara H Costa, Ana M Fernandes, Mara G Freire, Robin D Rogers, João A P Coutinho
Novel aqueous multiphase systems (MuPSs) formed by quaternary mixtures composed of cholinium-based ionic liquids (ILs), polymers, inorganic salts, and water are reported herein. The influence of several ILs, polymers, and salts was studied, demonstrating that a triple salting-out is a required phenomenon to prepare MuPSs. The respective phase diagrams and "tie-surfaces" were determined, followed by the evaluation of the effect of temperature. Finally, the remarkable ability of IL-based MuPSs to selectively separate mixtures of textile dyes is shown...
October 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28967063/comparative-study-of-urodynamic-tests-after-ams-800-and-zsi-375-insertion
#10
Thomas Ripert, Jean Pierrevelcin
STUDY DESIGN: Retrospective, non-randomised, single-centre study. OBJECTIVES: Comparative study of urodynamic tests in patients presenting social continence after AMS 800 or ZSI 375 insertion. MATERIALS AND METHODS: Study was open to patients with social continence, implanted with AMS 800 or ZSI 375. Vesical pressure (VP), urethral functional length (FL), maximal urethral pressure (MUP), maximal urethral closure pressure (MUCP), maximal urinary flow rate (Qmax) were registered with standard urodynamic equipment...
September 21, 2017: Urologia
https://www.readbyqxmd.com/read/28931741/major-urinary-protein-levels-are-associated-with-social-status-and-context-in-mouse-social-hierarchies
#11
Won Lee, Amber Khan, James P Curley
We have previously shown that male mice living in groups of 12 males establish and maintain stable linear social hierarchies with each individual having a defined social rank. However, it is not clear which social cues mice use to signal and recognize their relative social status within their hierarchy. In this study, we investigate how individual social status both in pairs and in groups affects the levels of major urinary proteins (MUPs) and specifically MUP20 in urine. We housed groups of adult outbred CD1 male mice in a complex social environment for three weeks and collected urine samples from all individuals repeatedly...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28916783/differential-regulation-of-vaginal-lipocalins-obp-mup-during-the-estrous-cycle-of-the-house-mouse
#12
Martina Černá, Barbora Kuntová, Pavel Talacko, Romana Stopková, Pavel Stopka
Female house mice produce pheromone-carrying major urinary proteins (MUPs) in a cycling manner, thus reaching the maximum urinary production just before ovulation. This is thought to occur to advertise the time of ovulation via deposited urine marks. This study aimed to characterize the protein content from the house mouse vaginal flushes to detect putative vaginal-advertising molecules for a direct identification of reproductive states. Here we show that the mouse vaginal discharge contains lipocalins including those from the odorant binding (OBP) and major urinary (MUP) protein families...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28857272/acanthoma-planoepitheliale-hyperkeratoticum-lesions-associated-with-braf-inhibitor-in-metastatic-melanoma
#13
M Sokołowska-Wojdyło, B Olszewska, M Sobjanek, M Sławińska, K Sosińska-Mielcarek, W Biernat, R Nowicki
A 68-year-old woman was diagnosed with BRAF V600 mutation positive melanoma of unknown primary (MUP) with metastasis to the lung, liver and brain. According to local standards dabrafenib monotherapy was started in July 2016. Control CT performed after two months revealed disease stabilization. The tolerance of therapy was good, but after 2 months of treatment with dabrafenib the patient developed disseminated skin lesions with extended seborrheic keratosis G2 (according to international common toxicity criteria CTC)...
August 30, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28844760/template-operated-mup-analysis-is-not-accurate-in-the-diagnosis-of-myopathic-or-neuropathic-changes-in-the-diaphragm
#14
Lea Leonardis, Simon Podnar
OBJECTIVES: The aim of this study was to evaluate the quantitative motor unit potential (MUP) analysis in the diagnosis of myopathy and neuropathy of the diaphragm. METHODS: Diaphragm template-operated quantitative EMG were performed in 30 patients with myotonic dystrophy type 1 (DM1), 17 with myotonic dystrophy type 2 (DM2) and 40 with amyotrophic lateral sclerosis (ALS). RESULTS: Low MUP amplitude precluded MUP analysis in 21% of DM1 patients...
August 24, 2017: Neurophysiologie Clinique, Clinical Neurophysiology
https://www.readbyqxmd.com/read/28825833/conformational-entropy-from-slowly-relaxing-local-structure-analysis-of-15-n-h-relaxation-in-proteins-application-to-pheromone-binding-to-mup-i-in-the-283-308-k-temperature-range
#15
Lukáš Žídek, Eva Meirovitch
The slowly relaxing local structure (SRLS) approach is applied to (15)N-H relaxation from the major urinary protein I (MUP-I), and its complex with pheromone 2-sec-butyl-4,5-dihydrothiazol. The objective is to elucidate dynamics, and binding-induced changes in conformational entropy. Experimental data acquired previously in the 283-308 K temperature range are used. The N-H bond is found to reorient globally with correlation time, τ1,0, and locally with correlation time, τ2,0, where τ1,0 ≫ τ2,0. The local motion is restricted by the potential u = -c0(2)D00(2), where D00(2) is the Wigner rotation matrix element for L = 2, K = 0, and c0(2) evaluates the strength of the potential...
September 8, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28823093/candida-albicans-staphylococcus-aureus-dual-species-biofilm-as-a-target-for-the-combination-of-essential-oils-and-fluconazole-or-mupirocin
#16
Aleksandra Budzyńska, Sylwia Różalska, Beata Sadowska, Barbara Różalska
The effectiveness of essential oils (EOs), fluconazole (FLU) and mupirocin (MUP) used alone or in combination against mono-species and mixed Candida albicans/Staphylococcus aureus biofilms was examined. An experimentally established dual-species biofilm model, verified by fluorescence microscopy and viable cell counting, was used. Selected commercial EOs were tested: geranium, citronella and clove oils, which have been chemically characterized and found to differ in the content of the main components (qualitative and quantitative)...
August 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28780276/uv-imaging-of-multiple-unit-pellet-system-mups-tablets-a-case-study-of-acetylsalicylic-acid-stability
#17
Anna Novikova, Jens M Carstensen, Thomas Rades, Claudia S Leopold
The applicability of multispectral ultraviolet (UV) imaging in combination with multivariate image analysis was investigated to monitor API degradation within multiple unit pellet system (MUPS) tablets during storage. For this purpose, acetylsalicylic acid (ASA) layered pellets were coated with Eudragit® RL PO and compressed to MUPS tablets. These tablets were stored under four different conditions with different levels of relative humidity (0 and 75%) and temperature (21 and 40°C) and analysed at seven storage time points (0, 15, 40, 140, 165, 265, and 330d)...
October 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28768896/the-effects-of-graded-levels-of-calorie-restriction-xi-evaluation-of-the-main-hypotheses-underpinning-the-life-extension-effects-of-cr-using-the-hepatic-transcriptome
#18
Davina Derous, Sharon E Mitchell, Lu Wang, Cara L Green, Yingchun Wang, Luonan Chen, Jing-Dong J Han, Daniel E L Promislow, David Lusseau, Alex Douglas, John R Speakman
Calorie restriction (CR) may extend longevity by modulating the mechanisms involved in aging. Different hypotheses have been proposed for its main mode of action. We quantified hepatic transcripts of male C57BL/6 mice exposed to graded levels of CR (0% to 40% CR) for three months, and evaluated the responses relative to these various hypotheses. Of the four main signaling pathways implied to be linked to the impact of CR on lifespan (insulin/insulin like growth factor 1 (IGF-1), nuclear factor-kappa beta (NF-ĸB), mechanistic target of rapamycin (mTOR) and sirtuins (SIRTs)), all the pathways except SIRT were altered in a manner consistent with increased lifespan...
July 31, 2017: Aging
https://www.readbyqxmd.com/read/28746931/treatment-outcomes-for-metastatic-melanoma-of-unknown-primary-in-the-new-era-a-single-institution-study-and-review-of-the-literature
#19
Kierstin Utter, Chloe Goldman, Sarah A Weiss, Richard L Shapiro, Russell S Berman, Melissa Ann Wilson, Anna C Pavlick, Iman Osman
BACKGROUND: Metastatic melanoma of unknown primary (MUP) is uncommon, biologically ill defined, and clinically understudied. MUP outcomes are seldom reported in clinical trials. In this study, we analyze responses of MUP patients treated with systemic therapy in an attempt to inform treatment guidelines for this unique population. METHODS: New York University (NYU)'s prospective melanoma database was searched for MUP patients treated with systemic therapy. PubMed and Google Scholar were searched for MUP patients treated with immunotherapy or targeted therapy reported in the literature, and their response and survival data were compared to the MUP patient data from NYU...
2017: Oncology
https://www.readbyqxmd.com/read/28712418/the-cross-sectional-relation-between-medically-unexplained-physical-symptoms-mups-and-the-cortisol-awakening-response
#20
Nikki Claassen-van Dessel, Johannes C van der Wouden, Joost Dekker, Judith G M Rosmalen, Henriëtte E van der Horst
OBJECTIVES: We aimed to assess the cross-sectional relation between levels of cortisol and specific symptom clusters, symptom severity and duration of symptoms in patients with medically unexplained physical symptoms (MUPS). METHODS: Baseline data of a cohort of MUPS patients were used. We chose the Cortisol Awakening Response (CAR) as a cortisol parameter, using saliva samples. We used confirmatory factor analysis for the identification of 4 specific symptom clusters: (1) gastro-intestinal symptoms; (2) pain; (3) cardio-pulmonary symptoms; and (4) fatigue...
August 2017: Journal of Psychosomatic Research
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