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https://www.readbyqxmd.com/read/29691976/time-together-a-nursing-intervention-in-psychiatric-inpatient-care-feasibility-and-effects
#1
Jenny Molin, Britt-Marie Lindgren, Ulla Hällgren Graneheim, Anders Ringnér
The facilitation of quality time between patients and staff in psychiatric inpatient care is useful to promote recovery and reduce stress experienced by staff. However, interventions are reported to be complex to implement and are poorly described in the literature. This multisite study aimed to evaluate the feasibility and effects of the nursing intervention Time Together, using mixed methods. Data consisted of notes from participant observations and logs to evaluate feasibility, and questionnaires to evaluate effects...
April 25, 2018: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/29691962/gastrointestinal-symptoms-in-children-primary-care-and-specialist-interface
#2
REVIEW
Valeria Dipasquale, Domenico Corica, Simone M C Gramaglia, Simona Valenti, Claudio Romano
AIMS: Gastrointestinal symptoms and diseases represent one of the major reasons for paediatricians' requests for specialist consultations and hospital admissions. One fourth of annual medical consultations for children younger than 6 years can be attributed to gastrointestinal symptoms. High-quality guidelines have been validated worldwide to provide clinical recommendations and support healthcare providers' practice. Nevertheless, overall compliance to standards of care is unsatisfactory, and children with gastrointestinal symptoms frequently undergo expensive, useless specialist consultations and laboratory evaluations...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691948/lifestyle-factors-and-the-course-of-depression-in-older-adults-a-nesdo-study
#3
REVIEW
Myrthe C Bruin, Hannie C Comijs, Rob M Kok, Roos C Van der Mast, Julia F Van den Berg
OBJECTIVES: To investigate whether lifestyle indicators including physical exercise, sleep duration, alcohol use, body mass index, smoking status, and a composite lifestyle index are associated with the depression course in older adults. METHODS: Data of 283 older adults were used from the Netherlands Study of Depression in Older Persons. Depressive disorders at baseline were assessed with the Composite International Diagnostic Interview. The depression course at 2-year follow-up was assessed with the Inventory of Depressive Symptoms (IDS, score 0-84) every 6 months; physical exercise with the International Physical Activity Questionnaire; alcohol use with the Alcohol Use Disorders Identification Test; body mass index by anthropometry; and sleep duration and smoking status by interview questions...
April 24, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29691947/using-bivariate-latent-basis-growth-curve-analysis-to-better-understand-treatment-outcome-in-youth-with-anorexia-nervosa
#4
Catherine E Byrne, Joseph A Wonderlich, Timothy Curby, Sarah Fischer, James Lock, Daniel Le Grange
OBJECTIVE: This study explored the relation between eating-related obsessionality and weight restoration utilizing bivariate latent basis growth curve modelling. Eating-related obsessionality is a moderator of treatment outcome for adolescents with anorexia nervosa (AN). This study examined the degree to which the rate of change in eating-related obsessionality was associated with the rate of change in weight over time in family-based treatment (FBT) and individual therapy for AN. METHOD: Data were drawn from a 2-site randomized controlled trial that compared FBT and adolescent focused therapy for AN...
April 25, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/29691943/distinguishable-brain-networks-relate-disease-susceptibility-to-symptom-expression-in-schizophrenia
#5
Zhaowen Liu, Jie Zhang, Kai Zhang, Junying Zhang, Xiaojing Li, Wei Cheng, Mingli Li, Liansheng Zhao, Wei Deng, Wanjun Guo, Xiaohong Ma, Qiang Wang, Paul M Matthews, Jianfeng Feng, Tao Li
Disease association studies have characterized altered resting-state functional connectivities describing schizophrenia, but failed to model symptom expression well. We developed a model that could account for symptom severity and meanwhile relate this to disease-related functional pathology. We correlated BOLD signal across brain regions and tested separately for associations with disease (disease edges) and with symptom severity (symptom edges) in a prediction-based scheme. We then integrated them in an "edge bi-color" graph, and adopted mediation analysis to test for causality between the disease and symptom networks and symptom scores...
April 24, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29691939/genome-sequencing-reveals-a-novel-genetic-mechanism-underlying-dihydropyrimidine-dehydrogenase-deficiency-a-novel-missense-variant-c-1700g-a-and-a-large-intragenic-inversion-in-dpyd-spanning-intron-8-to-intron-12
#6
André B P van Kuilenburg, Maja Tarailo-Graovac, Judith Meijer, Britt Drogemoller, Jerry Vockley, Dirk Maurer, Doreen Dobritzsch, Colin J Ross, Wyeth Wasserman, Rutger Meinsma, Lida Zoetekouw, Clara D M van Karnebeek
Dihydropyrimidine dehydrogenase (DPD) deficiency is associated with a variable clinical presentation. A family with three DPD deficient patients presented with unusual clinical phenotypes including pregnancy-induced symptoms, transient visual impairment, severe developmental delay, cortical blindness and delayed myelination in the brain. DPYD Sanger sequencing showed heterozygosity for the c.1905+1G > A mutation and a novel missense variant c.1700G > A (p.G456E). The recombinantly-expressed p.G456E DPD variant showed increased temperature lability probably caused by structural rearrangements within the DPD protein...
April 24, 2018: Human Mutation
https://www.readbyqxmd.com/read/29691918/the-relationships-among-aberrant-salience-reward-motivation-and-reward-sensitivity
#7
Suzanne R Neumann, Richard J Linscott
OBJECTIVES: Change in reward processing and motivation may mediate the relationship between dopaminergic dysregulation and positive symptoms of schizophrenia. We sought to investigate the measurement of aberrant salience and its relationship with behavioural measures of reward and motivation. METHODS: Participants (n = 82) completed measures of aberrant salience (Aberrant Salience Inventory and Salience Attribution Task), motivation (Effort Expenditure for Rewards Task), and reinforcer sensitivity (Stimulus Chase Task)...
April 24, 2018: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/29691866/gold-lotion-from-citrus-peel-extract-ameliorates-imiquimod-induced-psoriasis-like-dermatitis-in-murine
#8
Chi-Chien Lin, Jung-Ju Wu, Yi-Gen Pan, Ya-Hsuan Chao, Fang-Chu Lin, Ying-Ray Lee, Ching-Liang Chu
BACKGROUND: A natural mixed product Gold lotion (GL), which is made from the peels of six citrus fruits, has recently been identified to possess anti-oxidative, anti-inflammatory, and immunomodulatory effects. GL has been used to protect skin against UV-induced damage, but the activity to psoriasis, a chronic autoimmune skin disease caused by dysregulation between immune cells and keratinocytes, is not known. Thus, we evaluated the effect of GL on imiquimod (IMQ)-induced psoriasis-like inflammation in mice...
April 24, 2018: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29691791/does-religiosity-reduce-narcissistic-personality-disorder-examining-the-case-of-muslim-university-students
#9
Muhammad Ayub Buzdar, Riaz Ul Haq Tariq, Hina Jalal, Mohammad Nadeem
The purpose of this study was to examine the influences of religiousness on the prevalence of Narcissistic Personality Disorder (NPD) among young adults. Prevalence of three forms of Allportian religious orientation, three forms of quest religious orientation and seven symptoms of NPD were examined through self-reported measures. 618 randomly selected Muslim students from the four public sector Pakistani universities participated in the study. Three research instruments comprising Religious Orientation Scale developed by Gorsuch and McPherson, Quest Scale developed by Batson and Schoenrade and Narcissistic Personality Inventory developed by Raskin and Terry were used to collect the data...
April 24, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29691771/neuropathic-pain-is-it-an-underestimated-symptom-in-systemic-sclerosis
#10
Nihan Cuzdan, Ipek Turk, Tunay Sarpel, Eren Erken, Zeliha Nazan Alparslan
Pain is one of the most common symptoms in systemic sclerosis (SSc) patients, yet not considered in the assessment of disease severity. This study aimed to investigate the frequency of neuropathic pain (NP) and to evaluate its interference with the quality of life (QoL) in SSc patients. Diffuse and Limited SSc patients diagnosed by American College of Rheumatology 2013 criteria were included in the study. Pain was evaluated with Visual Analogue Scale (VAS); presence of NP was screened with The Leeds Assessment of Neuropathic Symptoms and Signs (LANNS) questionnaire; disease activity was evaluated with modified Medsger Severity Scale (MSS) and QoL with short-form 36 (SF-36)...
April 24, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29691769/long-term-effects-of-chemical-warfare-on-post-traumatic-stress-disorder-depression-and-chronic-medical-conditions-in-veterans
#11
Hamideh Safi-Aghdam, Mehrzad Shafie, Alireza Khoshdel, Ehsan Moazen-Zadeh, Farhad Avakh, Arash Rahmani
We investigated the association between exposure to chemical warfare and chronic mental/physical conditions. This was a secondary analysis of data from a case-control study on Iranian male veterans. Participants with neuropsychiatric disorders other than depressive/anxiety disorders, anatomical defects, or malignancies were excluded. Compared to non-exposed veterans, exposed veterans demonstrated significantly higher odds of PTSD [OR (95% CI) = 5.23 (1.98-13.85)], hypertension [OR (95% CI) = 5.57 (1.68-18...
April 24, 2018: Community Mental Health Journal
https://www.readbyqxmd.com/read/29691736/metastatic-melanoma-to-the-colon-rectum-and-anus-a-50-year-experience
#12
Jin-Soo Park, Kheng-Seong Ng, Robyn P M Saw, John F Thompson, Christopher J Young
BACKGROUND: Melanoma metastatic to the large bowel (colon, rectum, and anus) is rarely diagnosed, with more than 95% of large bowel metastases identified post-mortem. The incidence, natural history, and survival rates of patients with large bowel melanoma metastases are poorly documented in the literature. OBJECTIVE: This study aimed to identify the incidence, clinical characteristics, and survival of patients with large bowel melanoma metastases. METHODS: A review was undertaken of all patients with melanoma treated over a 50-year period (1964-2014) at a tertiary referral center...
April 24, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29691720/invariance-of-adhd-symptoms-across-sex-and-age-a-latent-analysis-of-adhd-and-impairment-ratings-from-early-childhood-into-adolescence
#13
Daniel R Leopold, Micaela E Christopher, Richard K Olson, Stephen A Petrill, Erik G Willcutt
A population-based longitudinal sample of 489 twin pairs was assessed at six time points over ten years to examine the measurement invariance and stability of attention-deficit/hyperactivity disorder (ADHD) symptoms, as well as the developmental relations between inattention (IN), hyperactivity-impulsivity (HI), and multiple aspects of functional impairment. Parent ratings of ADHD symptoms and functional impairment were obtained in preschool and after the completion of kindergarten, first, second, fourth, and ninth grades...
April 25, 2018: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/29691708/generation-of-insulin-deficient-piglets-by-disrupting-ins-gene-using-crispr-cas9-system
#14
Bumrae Cho, Su Jin Kim, Eun-Jin Lee, Sun Mi Ahn, Jin Seok Lee, Dal-Young Ji, Kiho Lee, Jung-Taek Kang
Diabetes mellitus is a chronic disease with accompanying severe complications. Various animal models, mostly rodents due to availability of genetically modified lines, have been used to investigate the pathophysiology of diabetes. Using pigs for diabetic research can be beneficial because of their similarity in size, pathogenesis pathway, physiology, and metabolism with human. However, the use of pigs for diabetes research has been hampered due to only few pig models presenting diabetes symptoms. In this study, we have successfully generated insulin-deficient pigs by generating the indels of the porcine INS gene in somatic cells using CRISPR/Cas9 system followed by somatic cell nuclear transfer...
April 24, 2018: Transgenic Research
https://www.readbyqxmd.com/read/29691705/retinal-dysfunction-in-a-presymptomatic-patient-with-huntington-s-disease
#15
Jonelle Knapp, Dean A VanNasdale, Keith Ramsey, Julie Racine
PURPOSE: Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder characterized by progressive motor dysfunction, cognitive decline, and psychiatric disturbances. Studies have shown retinal abnormalities in patients and mouse models with HD; however, to our knowledge, no prior research papers evaluated retinal structure and function in a presymptomatic patient with HD. The aim of this report is to present a case of retinal dysfunction in a presymptomatic patient with HD...
April 24, 2018: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/29691658/associations-of-psychosocial-working-conditions-with-health-outcomes-quality-of-care-and-intentions-to-leave-the-profession-results-from-a-cross-sectional-study-among-physician-assistants-in-germany
#16
Patricia Vu-Eickmann, Jian Li, Andreas Müller, Peter Angerer, Adrian Loerbroks
BACKGROUND: Numerous epidemiological studies among health care staff have documented associations of adverse psychosocial working conditions with poorer health-related outcomes, a reduced quality of patient care and intentions to leave the profession. The evidence for physician assistants in Germany remains limited though. METHODS: We surveyed a total of 994 physician assistants between September 2016 and April 2017. Psychosocial working conditions were measured by the established effort-reward imbalance (ERI) questionnaire and by a questionnaire specifically developed to capture psychosocial working conditions among physicians...
April 24, 2018: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/29691618/patients-with-an-achilles-tendon-re-rupture-have-long-term-functional-deficits-in-function-and-worse-patient-reported-outcome-than-primary-ruptures
#17
Olof Westin, Katarina Nilsson Helander, Karin Grävare Silbernagel, Kristian Samuelsson, Annelie Brorsson, Jón Karlsson
PURPOSE: The aim of this study was to perform a long-term follow-up of patients treated for an Achilles tendon re-rupture, using established outcome measurements for tendon structure, lower extremity function and symptoms, and to compare the results with those for the uninjured side. A secondary aim was to compare the outcome with that of patients treated for primary ruptures. The hypotheses were that patients with a re-rupture recover well, and have similar long-term outcome as primary ruptures...
April 24, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29691608/effects-of-the-monoamine-stabilizer-osu6162-on-locomotor-and-sensorimotor-responses-predictive-of-antipsychotic-activity
#18
Vívian T da Silveira, Jivago Röpke, Ana L Matosinhos, Ana C Issy, Elaine A Del Bel, Antônio C de Oliveira, Fabrício A Moreira
The monoamine stabilizer (3S)-3-[3-(methenesulfonyl)phenyl]-1-propylpiperidine hidrochloride [(-)-OSU6162] is a promising compound for the treatment of neurological and psychiatric disorders, such as schizophrenia. Here, we tested the hypothesis that (-)-OSU6162 prevents hyperlocomotion and sensorimotor deficits in prepulse inhibition of the startle response (PPI) induced by psychomimetic drugs. Male Swiss mice received injections of (-)-OSU6162 (1, 3, 10, or 30 mg/kg), and their motor responses were investigated in the open field and in the catalepsy tests, which predicts liability to induce sedation and extrapyramidal side effects, respectively...
April 24, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29691599/-primary-biliary-cholangitis-established-and-novel-therapies
#19
REVIEW
M Vetter, A E Kremer
BACKGROUND: Patients with primary biliary cholangitis (PBC, formerly primary biliary cirrhosis) and insufficient treatment response or risk factors exhibit a remarkably increased risk for disease progression and associated complications. Furthermore, extrahepatic manifestations may considerably reduce quality of life in affected patients. OBJECTIVES: This article presents an overview on standard therapy with ursodeoxycholic acid (UDCA) and further therapeutic options in patients with insufficient treatment response...
April 24, 2018: Der Internist
https://www.readbyqxmd.com/read/29691593/-interprofessional-symptom-management-at-the-end-of-life
#20
S Frankenhauser, M J P Geist, M A Weigand, H J Bardenheuer, J Keßler
At the end of life patients often show distressful symptoms which significantly reduce their quality of life. The goal of all healthcare professionals should be to recognize the beginning of this end of life period in order to provide good symptom management. For this purpose, existing symptoms have to be recorded, suitable therapeutic goals have to be defined for the current situation and potential therapeutic strategies have to be individually formulated. Besides the identification of underlying causes with the possibility of causal treatment, a symptom-based therapy is often necessary...
April 24, 2018: Der Urologe. Ausg. A
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