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https://www.readbyqxmd.com/read/29933513/aura-in-cluster-headache-a-cross-sectional-study
#1
Ilse F de Coo, Leopoldine A Wilbrink, Gaby D Ie, Joost Haan, Michel D Ferrari
BACKGROUND: Aura symptoms have been reported in up to 23% of cluster headache patients, but it is not known whether clinical characteristics are different in participants with and without aura. METHODS: Using validated web-based questionnaires we assessed the presence and characteristics of attack-related aura and other clinical features in 629 subjects available for analysis from an initial cohort of 756 cluster headache subjects. Participants who screened positive for aura were contacted by telephone for confirmation of the ICHD-III criteria for aura...
June 22, 2018: Headache
https://www.readbyqxmd.com/read/29933492/group-communication-treatment-for-individuals-with-ppa-and-their-partners
#2
Aimee Mooney, Naomi Beale, Melanie Fried-Oken
Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by insidious language deterioration. This young-onset disorder leaves adults with reduced communication skills for participation in social activities. There is limited evidence regarding group treatment for individuals with PPA, though the principles of chronic aphasia groups can be applied to this clinical population. We developed a PPA group treatment model incorporating compensatory strategies from augmentative and alternative communication (AAC), communication partner training from aphasia rehabilitation, and systematic instruction from dementia management...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933491/treatment-for-lexical-retrieval-impairments-in-primary-progressive-aphasia-a-research-update-with-implications-for-clinical-practice
#3
Karen Croot
Lexical retrieval impairments (also known as anomia or word-finding deficits) are an early and prominent symptom in primary progressive aphasia (PPA), causing distress and frustration to individuals with PPA and their communication partners, and prompting research on lexical retrieval treatment. This paper reviews the research on lexical retrieval treatment in PPA from the earliest reports in the 1990s to early 2018 and considers the implications of this research for clinical practice. The number of published studies has increased markedly over the past decade, consisting primarily of behavioral studies, with rapid recent growth in noninvasive brain stimulation studies...
July 2018: Seminars in Speech and Language
https://www.readbyqxmd.com/read/29933484/-modern-management-of-pancoast-tumour
#4
Alessandro Marra
Pancoast or superior pulmonary sulcus tumour is a subset of lung carcinoma that invades the structures of the thoracic inlet - first ribs, distal roots of the brachial plexus, stellate ganglion, vertebrae, and subclavian vessels. The first symptom is usually shoulder pain; consequently, most patients are initially treated for osteoarthritis. Late diagnosis is common. Success of therapy depends on an accurate staging: standard imaging with CT scan of the chest, PET-CT scan, brain MRI are needed to rule out distant metastases, endobronchial ultrasound-guided needle biopsy (EBUS-TBNA) or mediastinoscopy are mandatory for reliable nodal staging...
June 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29933481/-outpatient-drain-management-in-patients-with-clinically-relevant-postoperative-pancreatic-fistula-cr-popf-current-status-in-germany
#5
Sebastian Hempel, Pamela Püttmann, Christoph Kahlert, Lena Seifert, Sören Torge Mees, Thilo Welsch, Jürgen Weitz, Marius Distler
INTRODUCTION: Postoperative pancreatic fistula (POPF) is a common complication after pancreatic surgery and is associated with extended hospitalisation, increased medical costs, and reduced quality of life. The aim of the present study was to assess the treatment of POPF in Germany, with a special focus on outpatient drain management in patients with clinically relevant POPF (CR-POPF). METHODS: A questionnaire evaluating postoperative management once a CR-POPF is diagnosed - especially focusing on ambulatory drain management - was developed and sent to 211 German hospitals performing > 12 pancreatic operations per year...
June 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29933461/arrested-hydrocephalus-in-childhood-case-series-and-review-of-the-literature
#6
Yannick Hurni, Andrea Poretti, Jacques Schneider, Raphael Guzman, Gian Paolo Ramelli
INTRODUCTION:  Hydrocephalus can be progressive or spontaneously arrested. In arrested hydrocephalus, the balance between production and absorption of the cerebrospinal fluid is restored. Patients are mostly asymptomatic, and no surgical treatment is necessary for them. METHODS:  We performed a two-center consecutive case series study, aimed at investigating the safety of nonsurgical management of hydrocephalus in selected pediatric patients. We retrospectively selected all consecutive patients, suspected to suffer from arrested hydrocephalus and referred to our two institutions between January 2011 and December 2013...
June 22, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29933418/understanding-patient-discharge-in-leprosy-a-concept-analysis
#7
Mônica Gisele Costa Pinheiro, Francisco Arnoldo Nunes de Miranda, Clélia Albino Simpson, Francisca Patrícia Barreto de Carvalho, Cáthia Alessandra Varela Ataide, Ana Luisa Brandão de Carvalho Lira
OBJECTIVE: To analyze the concept of patient discharge in leprosy. METHODS: Theoretical study guided in the methodological framework of concept analysis. A bibliographical survey was held from December 2015 to January 2016 using the following bases: SCOPUS, CINAHL, PubMed, LILACS, SCIELO and BDENF, by use of the descriptors "Leprosy" and "Patient Discharge", resulting in 13 studies. RESULTS: The following were identified as possible uses for the concept: discharge by cure, drug use discharge, bacteriological discharge and post-discharge...
June 7, 2018: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/29933411/time-trends-in-dyspepsia-and-association-with-h-pylori-and-work-related-stress-an-observational-study-in-white-collar-employees-in-1996-and-2015
#8
Stefanie Braig, Simon Berger, David Rothenbacher, Stefanie Schmid, Thomas Seufferlein, Hermann Brenner, Dietrich Rothenbacher, Harald Gündel
PURPOSE: We aimed to describe time trends in functional dyspepsia and the association of dyspepsia-related factors, Helicobacter pylori (H. pylori) and work-related stress with functional dyspepsia in white collar employees in 1996 and 2015. MATERIALS AND METHODS: Repeat cross-sectional study conducted in 1996 (n = 190, response rate = 76.1) and 2015 (n = 195, response rate = 40.2) within a health insurance company in South-West Germany. Dyspeptic symptoms measured according to the Rome III criteria, effort-reward imbalance and further work- or dyspepsia-related factors were assessed by self-administered questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29933379/colonic-migrating-motor-complexes-are-inhibited-in-acute-tri-nitro-benzene-sulphonic-acid-colitis
#9
Ben R Hofma, Hannah R Wardill, Chris Mavrangelos, Melissa A Campaniello, David Dimasi, Joanne M Bowen, Scott D Smid, Claudine S Bonder, Elizabeth A Beckett, Patrick A Hughes
BACKGROUND: Inflammatory Bowel Disease (IBD) is characterized by overt inflammation of the intestine and is typically accompanied by symptoms of bloody diarrhea, abdominal pain and cramping. The Colonic Migrating Motor Complex (CMMC) directs the movement of colonic luminal contents over long distances. The tri-nitrobenzene sulphonic acid (TNBS) model of colitis causes inflammatory damage to enteric nerves, however it remains to be determined whether these changes translate to functional outcomes in CMMC activity...
2018: PloS One
https://www.readbyqxmd.com/read/29933371/tcf4-regulates-dendritic-spine-density-and-morphology-in-the-adult-brain
#10
Sophie Crux, Jochen Herms, Mario M Dorostkar
Tcf4 is a transcription factor which regulates neurogenesis and neuronal migration in the brain. In humans, loss of function of Tcf4 leads to the rare neurodevelopmental disorder Pitt-Hopkins syndrome, which is characterized by intellectual disability, developmental delay and autistic behavior. We analyzed the consequences of functional loss of Tcf4 on dendritic spines in mature principal neurons. To this end, we crossed mice in which the DNA-binding domain of the Tcf4 gene is flanked by LoxP sites to mice expressing tamoxifen-inducible cre recombinase in a sparse subset of fluorescently labelled neurons (SlickV line)...
2018: PloS One
https://www.readbyqxmd.com/read/29933369/meditation-or-exercise-for-preventing-acute-respiratory-infection-mepari-2-a-randomized-controlled-trial
#11
Bruce Barrett, Mary S Hayney, Daniel Muller, David Rakel, Roger Brown, Aleksandra E Zgierska, Shari Barlow, Supriya Hayer, Jodi H Barnet, Elisa R Torres, Christopher L Coe
BACKGROUND: Practice of meditation or exercise may enhance health to protect against acute infectious illness. OBJECTIVE: To assess preventive effects of meditation and exercise on acute respiratory infection (ARI) illness. DESIGN: Randomized controlled prevention trial with three parallel groups. SETTING: Madison, Wisconsin, USA. PARTICIPANTS: Community-recruited adults who did not regularly exercise or meditate...
2018: PloS One
https://www.readbyqxmd.com/read/29933364/pharmacokinetics-pharmacodynamics-safety-and-tolerability-of-single-dose-denosumab-in-healthy-chinese-volunteers-a-randomized-single-blind-placebo-controlled-study
#12
Qian Chen, Chaoying Hu, Yanmei Liu, Rong Song, Wenjing Zhu, Hongxin Zhao, Antonio Nino, Fan Zhang, Yun Liu
BACKGROUND: Denosumab is a fully human monoclonal antibody against receptor activator of nuclear factor kappa-B ligand, a cytokine essential for the formation, function and survival of osteoclasts. This study assessed the pharmacokinetics, pharmacodynamics, safety and tolerability of single-dose denosumab (60 and 120 mg) in healthy Chinese volunteers. METHODS: This randomized (3:3:2), single-blind, placebo-controlled study enrolled healthy Chinese volunteers to receive single subcutaneous injection of denosumab 60 mg, 120 mg, or placebo...
2018: PloS One
https://www.readbyqxmd.com/read/29933333/-as-black-as-ink-a-case-of-alkaptonuria-associated-myelopathy-and-a-review-of-the-literature
#13
Callum J Donaldson, Stuart L Mitchell, Lee H Riley, Khaled Kebaish
STUDY DESIGN: Case report and literature review. OBJECTIVE: To characterize the rare presentati on of myelopathy occurring secondary to alkaptonuria and to evaluate the available evidence regarding its treatment. SUMMARY OF BACKGROUND DATA: Alkaptonuria is an autosomal recessive genetic condition with an estimated incidence of 1 in 250,000 to 1 in 1,000,000 people. Mutation of the enzyme homogentisate 1,2-dioxygenase leads to the production of high levels of homogentisic acid (HGA), with subsequent deposition in ligaments, cartilage, and menisci...
June 21, 2018: Spine
https://www.readbyqxmd.com/read/29933327/mobile-apps-for-individuals-with-rheumatoid-arthritis-a-systematic-review
#14
Dee Luo, Penny Wang, Fengxin Lu, Josephine Elias, Jeffrey A Sparks, Yvonne C Lee
BACKGROUND: Mobile health applications (apps) have the potential to help individuals with chronic illnesses learn about, monitor, and manage their condition, but these apps are largely unexamined, with the state and direction of development unclear. OBJECTIVE: We performed a systematic review of publicly available apps, directed toward individuals with rheumatoid arthritis (RA); described their current features; and determined areas of unmet need. METHODS: We searched the iTunes and Google Play App Stores for the term "arthritis" and reviewed the descriptions of these apps for specific mentions of RA...
June 21, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29933322/cluster-analysis-using-anti-aminoacyl-trna-synthetases-and-ss-a-ro52-antibodies-in-patients-with-polymyositis-dermatomyositis
#15
Keiji Ohashi, Ken-Ei Sada, Yu Nakai, Shun Matsushima, Yosuke Asano, Keigo Hayashi, Yuriko Yamamura, Sumie Hiramatsu, Yoshia Miyawaki, Michiko Morishita, Takayuki Katsuyama, Eri Katsuyama, Haruki Watanabe, Noriko Tatebe, Mariko Narazaki, Yoshinori Matsumoto, Katsue Sunahori Watanabe, Tomoko Kawabata, Jun Wada
OBJECTIVE: Although several autoantibodies have been identified for polymyositis/dermatomyositis (PM/DM) diagnosis, the clinical impact of these antibodies is yet to be elucidated. METHODS: Patients with PM/DM at Okayama University Hospital from 2012 to 2016 were historically enrolled, and antibody profiles were analyzed using line immunoassay. Hierarchical cluster analysis was performed based on serological analysis of anti-aminoacyl-tRNA synthetase (ARS) antibodies, including anti-Jo-1, PL-7, PL-12, EJ, OJ, and SS-A/Ro-52 antibodies...
June 22, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29933307/impact-of-comorbidity-on-symptoms-and-quality-of-life-among-patients-being-treated-for-breast-cancer
#16
Horng-Shiuann Wu, Jean E Davis, Ling Chen
BACKGROUND: Cancer patients often have other noncancer medical conditions. Presence of comorbidities negatively affects cancer survival. OBJECTIVE: The aim of this study was to investigate comorbidity, risk factors for comorbidity, and how comorbidity was associated with symptoms and quality of life in patients being treated for breast cancer. METHODS: One hundred and one breast cancer chemotherapy outpatients completed this study. Comorbid conditions, weight, height, and smoking status were identified by chart review...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29933290/systematic-review-of-treatment-outcome-measures-for-vulvodynia
#17
Leslie A Sadownik, Paul J Yong, Kelly B Smith
OBJECTIVES OF THE STUDY: To systematically evaluate the literature regarding vulvodynia treatment outcome measures. METHODS: A systematic literature search on OVID, PubMed, and PsycINFO databases was conducted from inception until May 2016. Studies were included/excluded based on prespecified criteria. Reported outcome measures were organized into 6 core outcome domains recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT): pain; physical functioning, emotional functioning, participant ratings of global improvement and satisfaction with treatment, symptoms and adverse events, and participant disposition...
July 2018: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/29933282/concussion-symptom-profiles-among-child-adolescent-and-young-adult-athletes
#18
David R Howell, Peter Kriz, Rebekah C Mannix, Tyler Kirchberg, Christina L Master, William P Meehan
OBJECTIVES: (1) To examine how age influences initial symptom presentation following concussion; and (2) to determine whether specific symptom profiles are associated with duration of postconcussion symptoms, and whether they vary by age group. DESIGN: A total of 689 patients (20% children 7-12 years of age, 69% adolescents 13-18 years of age, and 11% young adults 19-30 years of age) were seen and diagnosed with a concussion within 21 days after injury. Patients completed the Post-Concussion Symptom Scale (PCSS) and were followed until they no longer required care...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29933281/differences-in-postinjury-psychological-symptoms-between-collegiate-athletes-with-concussions-and-orthopedic-injuries
#19
Jinhong Guo, Jingzhen Yang, Honggang Yi, Bhavna Singichetti, Despina Stavrinos, Corinne Peek-Asa
OBJECTIVE: To describe the differences in postinjury psychological symptoms among Division I collegiate student athletes who sustained concussions versus orthopedic injures and to examine the effects of injury type on postinjury psychological symptoms during the course of recovery. DESIGN: A prospective cohort study with repeated measures. SETTING: Two Big 10 Conference universities. PARTICIPANTS: Student athletes who were at least 18 years old and participated in one of 9 National Collegiate Athletic Association (NCAA) Division I-sponsored sports during the 2007 to 2011 seasons...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29933278/personality-and-risk-taking-in-sports-a-focus-on-unintentional-and-intentional-head-impacts-in-amateur-soccer-players
#20
Cara F Levitch, Chloe Ifrah, Mimi Kim, Walter F Stewart, Richard B Lipton, Molly E Zimmerman, Michael L Lipton
OBJECTIVE: In soccer, unintentional and intentional (heading) head impacts are associated with concussive symptoms and cognitive dysfunction. We examined whether personality traits were associated with these behaviors in soccer players. DESIGN: Cross-sectional study. SETTING AND PARTICIPANTS: Participants completed study visits at the Albert Einstein College of Medicine. A total of 307 adult amateur soccer players, recruited from New York City and the surrounding area, completed 737 HeadCount-2w questionnaires...
June 21, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
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