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https://www.readbyqxmd.com/read/29471606/-clinical-approach-to-abdominal-pain-as-functional-origin
#1
REVIEW
Han Seung Ryu, Suck Chei Choi
Abdominal pain is a common symptom that patients refer to a hospital. Organic causes should be differentiated in patients with abdominal pain and treatment should be administered in accordance with the causes. A meticulous history taking and physical examination are highly useful in making a diagnosis, and blood tests, imaging modalities, and endoscopy are useful for confirming diagnosis. However, in many cases, patients have functional disorders with no obvious abnormal findings obtained even if many diagnostic tests are performed...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471604/-how-to-optimally-use-currently-available-drugs-in-a-therapeutic-algorithm
#2
REVIEW
You Sun Kim
Recently, the incidence and prevalence of inflammatory bowel disease (IBD) have been increasing in worldwide, especially in Asian area. IBD is a chronic and progressive disease eventually causing bowel damage. The advance in the treatment of IBD over the past several decades has been achieved with the development of biologics. Furthermore, goals for management of IBD have been evolving from symptom-based management to mucosal healing, which can reduce the surgery rate and hospitalization. To treat the patients with IBD properly, identification of risk factors of patients should be preceded...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471603/-monitoring-disease-activity-how-and-when
#3
REVIEW
Kang Moon Lee
Inflammatory bowel disease (IBD) is a chronic, idiopathic inflammatory disease of gastrointestinal tract with waxing and waning clinical course, which may lead to irreversible bowel damage and a loss of bowel function. Cumulative intestinal damage results in complications such as stricture or fistulae, and eventually a large number of IBD patients undergo surgery. Notably, even during remission period (no clinical symptoms), subclinical inflammation often persists and the disease continues to progress. Therefore, the therapeutic target of IBD has been evolving from symptomatic control to mucosal healing to prevent structural intestinal damage...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#4
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471601/-bladder-rupture-during-intravesical-bcg-therapy-a-case-report
#5
Yusuke Iemura, Shinji Fukui, Yoshiaki Matsumura, Yoriaki Kagebayashi, Yuta Toyoshima, Takeshi Inoue, Shoji Samma
A 69-year-old man received transurethral resection (TUR) ofbladder tumor. The histopathological diagnosis was urothelial carcinoma, high grade, pT1+pTis. The surgical specimens obtained by second TUR showed no residual malignancy histopathologically. Intravesical Bacillus Calmette-Guerin (BCG) instillation therapy was initiated 2 months after the second TUR. He complained of lower abdominal pain and painful urination on the day following the second instillation of BCG. Computed tomography and cystography demonstrated rupture ofthe urinary bladder...
January 2018: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/29471586/inflammatory-back-pain-and-axial-spondyloarthritis-lessons-for-clinical-practice-and-epidemiological-research
#6
EDITORIAL
Maureen Dubreuil, Joachim Sieper
The delay between symptom onset and diagnosis in axial spondyloarthritis (axSpA) remains unacceptably long; recently estimated to still be more than 6 years.1 Accumulating data demonstrates that early treatment with TNF-inhibitors reduces both disease activity and radiographic progression in ankylosing spondylitis, the prototypic form of axSpA.2 3 To encourage timely and correct diagnosis and enable early treatment, strategies to better identify patients with axSpA have been studied in several populations.4 This article is protected by copyright...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471572/-cardiovascular-medication-in-elderly-patients
#7
Robert H G Schwinger
Elderly people show increased probability to develop atherosclerotic diseases; in consequence heart failure - most often following coronary heart disease - as well as atrial fibrillation is more common. Following guidelines may lead to polypharmacy, i. e. use of more than 5 drugs daily. Thus, drug interactions as well as side effects become more likely; especially in elderly patients reduced kidney function has to be taken into account. Only drugs which have shown to prolong life or to reduce symptoms in controlled clinical trials should be used...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471560/knochensarkome
#8
Jendrik Hardes, Georg Gosheger, Timo Budny
Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471551/bilateral-striatal-necrosis-after-sydenham-s-chorea-in-a-7-year-old-boy-a-2-year-follow-up
#9
C Canavese, C Davico, M Casabianca, C Olivieri, S Mancini, G Migliore, A Versace, A Tocchet, B Vitiello
Child bilateral striatal necrosis (BSN) is a rare and etiologically heterogeneous condition. An association with group A streptococcus (GAS) infection was previously reported in two cases of BSN in infancy and early childhood. We here report on a 7-year-old boy who developed chorea and dystonia 20 days after symptomatic recovery from Sydenham's chorea. Repeated brain magnetic resonance imaging scans, obtained before, soon after the onset of the post-Sydenham symptoms, and 1 year later were consistent with an evolution from bilateral striatal microbleeding to necrosis, and consequently reduced basal ganglia volume and enlargement of the frontal horns...
February 22, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29471549/glutamate-dehydrogenase-deficient-mice-display-schizophrenia-like-behavioral-abnormalities-and-ca1-specific-hippocampal-dysfunction
#10
Sharon S Lander, Usman Khan, Nicole Lewandowski, Darpan Chakraborty, Frank A Provenzano, Susana Mingote, Sergiy Chornyy, Francesca Frigerio, Pierre Maechler, Hanoch Kaphzan, Scott A Small, Stephen Rayport, Inna Gaisler-Salomon
Brain imaging has revealed that the CA1 subregion of the hippocampus is hyperactive in prodromal and diagnosed patients with schizophrenia (SCZ), and that glutamate is a driver of this hyperactivity. Strikingly, mice deficient in the glutamate synthetic enzyme glutaminase have CA1 hypoactivity and a SCZ-resilience profile, implicating glutamate-metabolizing enzymes. To address this further, we examined mice with a brain-wide deficit in the glutamate-metabolizing enzyme glutamate dehydrogenase (GDH), encoded by Glud1, which should lead to glutamate excess due to reduced glutamate metabolism in astrocytes...
February 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471538/novel-roles-of-ascorbate-in-plants-induction-of-cytosolic-ca2-signals-and-efflux-from-cells-via-anion-channels
#11
M Makavitskaya, D Svistunenko, I Navaselsky, P Hryvusevich, V Mackievic, C Rabadanova, E Tyutereva, V Samokhina, D Straltsova, A Sokolik, O Voitsekhovskaja, V Demidchik
Ascorbate is not often considered as a signalling molecule in plants. This study demonstrates that, in Arabidopsis roots, exogenous L-ascorbic acid triggers a transient increase of the cytosolic free calcium activity ([Ca2+]cyt.) that is central to plant signalling. Exogenous copper and iron stimulates the ascorbate-induced [Ca2+]cyt. elevation while cation channel blockers, free radical scavengers, low extracellular [Ca2+], transition metal chelators and removal of the cell wall inhibit this reaction. These data show that apoplastic redox-active transition metals are involved in the ascorbate-induced [Ca2+]cyt...
February 17, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29471493/the-effect-of-pregnancy-on-endometriosis-facts-or-fiction
#12
Brigitte Leeners, Fabia Damaso, Nicole Ochsenbein-Kölble, Cindy Farquhar
BACKGROUND: It is not uncommon for women with endometriosis to be advised that becoming pregnant might be a useful strategy to manage their symptoms and reduce disease progression. Consequently, many women diagnosed with endometriosis and motivated to become pregnant, may also have expectations regarding improvement of symptoms and the disease. However, study results on the effect of pregnancy on endometriosis are controversial and pregnancy in women with endometriosis is not always associated with improved symptoms...
February 15, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29471331/cross-cultural-validation-and-extension-of-the-clinical-assessment-interview-for-negative-symptoms-cains-in-the-chinese-context-evidence-from-a-spectrum-perspective
#13
Dong-Jie Xie, Hai-Song Shi, Simon S Y Lui, Chuan Shi, Ying Li, Karen K Y Ho, Karen S Y Hung, Wen-Xiu Li, Zheng-Hui Yi, Eric F C Cheung, Ann M Kring, Raymond C K Chan
The Clinical Assessment Interview for Negative Symptoms (CAINS) was designed in accordance with the recent theory and research in social affective neuroscience and to address the psychometric and conceptual limitations of other instruments assessing negative symptoms. The present study aimed to provide a large-scale validation of the CAINS in China and examine its applicability and validity evidence across the schizophrenia spectrum. Using confirmatory factor analysis, our results replicated the original findings in the US development samples that the CAINS possesses a stable 2-factor structure, namely "motivation/pleasure" and "expression"...
February 20, 2018: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/29471329/effects-of-varenicline-depressive-symptoms-and-region-of-enrollment-on-smoking-cessation-in-depressed-smokers
#14
Neal Doran, Sarah Dubrava, Robert M Anthenelli
Introduction: Despite effective treatments, relapse to smoking remains a vexing global health problem. One predictor of relapse is depressive symptoms. Medications such as varenicline reduce withdrawal-related symptoms of depression, reducing relapse. This study examined whether varenicline moderated the effect of depressive symptoms on relapse, and whether this varied by region of enrollment. Methods: Adult smokers (n=525; 37% male) with past or current, stable major depressive disorder recruited from US (n=255), and European (n=270) sites participated in a randomized, double-blind cessation treatment trial including 12 weeks of varenicline or placebo, with 40-week non-treatment follow-up...
February 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29471260/stress-underestimation-and-mental-health-literacy-of-depression-in-japanese-workers-a-cross-sectional-study
#15
Nanako Nakamura-Taira, Shuhei Izawa, Kosuke Chris Yamada
Appropriately estimating stress levels in daily life is important for motivating people to undertake stress-management behaviors or seek out information on stress management and mental health. People who exhibit high stress underestimation might not be interested in information on mental health, and would therefore have less knowledge of it. We investigated the association between stress underestimation tendency and mental health literacy of depression (i.e., knowledge of the recognition, prognosis, and usefulness of resources of depression) in Japanese workers...
January 2, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29471247/family-functioning-and-adolescent-internalizing-symptoms-a-latent-profile-analysis
#16
Emily G Simpson, Anna Vannucci, Christine McCauley Ohannessian
This study aimed to characterize adolescent family functioning typologies using latent profile analysis (LPA). A secondary aim was to examine profile associations with adolescent internalizing symptoms at one-year follow-up. Students (N = 1029; 53% female; mean age = 16.14, SD = .75 years) completed measures of family functioning, anxiety, and depressive symptoms at two time points. LPA was conducted to characterize family functioning typologies at Time 1, revealing five profiles: 1) Low Family Functioning, 2) Only Close to Father, 3) Average Family Functioning, 4) Only Close to Mother, and 5) High Family Functioning...
February 19, 2018: Journal of Adolescence
https://www.readbyqxmd.com/read/29471226/examining-effects-of-medical-cannabis-narratives-on-beliefs-attitudes-and-intentions-related-to-recreational-cannabis-a-web-based-randomized-experiment
#17
Sharon R Sznitman, Nehama Lewis
BACKGROUND: This experimental study tests effects of exposure to video narratives about successful symptom relief with Medical Cannabis (MC) on attitudes, beliefs, and intentions related to recreational cannabis use. METHODS: Patient video testimonials were modeled after those found in extant media coverage. Israeli participants (N = 396) recruited through an online survey company were randomly assigned to view a narrative or a non-narrative video containing equivalent information about MC...
January 31, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29471180/linking-financial-hardship-throughout-the-life-course-with-psychological-distress-in-old-age-sensitive-period-accumulation-of-risks-and-chain-of-risks-hypotheses
#18
Alexander Darin-Mattsson, Ross Andel, Roger Keller Celeste, Ingemar Kåreholt
The primary objective was to investigate the life course hypotheses - sensitive period, chain of risks, and accumulation of risks - in relation to financial hardship and psychological distress in old age. We used two Swedish longitudinal surveys based on nationally representative samples. The first survey includes people 18-75 years old with multiple waves, the second survey is a longitudinal continuation, including people 76 + years old. The analytical sample included 2990 people at baseline. Financial hardship was assessed in childhood (retrospectively), at the mean ages of 54, 61, 70, and 81 years...
February 17, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29471161/peripheral-artery-disease-and-antiplatelet-treatment
#19
REVIEW
Vasiliki Tsigkou, Gerasimos Siasos, Kleanthis Rovos, Niki Tripyla, Dimitris Tousoulis
Peripheral artery disease (PAD) is one of the most important causes of cardiovascular morbidity and mortality and its prevalence is alarmingly increasing in modern societies. PAD shares common characteristics with the other atherosclerotic diseases but involves specifically the arteries of the lower extremities. Apart from the changes in lifestyle, antiplatelet agents are the hallmark of the treatment and improve the symptoms as well as the progression of the disease. Aspirin is the cornerstone of treatment and is administrated in doses ranging from 75 to 325mg daily...
February 19, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29471159/operation-versus-watchful-waiting-in-asymptomatic-or-minimally-symptomatic-inguinal-hernias-the-meta-analysis-results-of-randomized-controlled-trials
#20
REVIEW
Wenbin Gong, Junsheng Li
INTRODUCTION: The aim of this article was to compare and analyze the outcomes of surgical repair and watchful waiting (WW) in the treatment of asymptomatic or minimally symptomatic inguinal hernias. METHODS: A systematic literature review was undertaken to identify studies that compare surgical repair and watchful waiting in asymptomatic or minimally symptomatic inguinal hernias. And all related data matching our standards were abstracted for Meta-analysis with RevMan 5...
February 19, 2018: International Journal of Surgery
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