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https://www.readbyqxmd.com/read/28738518/teucrium-polium-extract-reverses-symptoms-of-streptozotocin-induced-diabetes-in-rats-via-rebalancing-the-pdx1-and-foxo1-expressions
#1
Parvaneh Sadat Tabatabaie, Razieh Yazdanparast
BACKGROUND AND OBJECTIVE: Teucrium polium Lamiaceae. an antidiabetic traditional medicine was observed to stimulate insulin secretion and β-cell mass restoration in pancreatic of diabetic rats. Bioactive compounds in T. polium such as terpenoids and flavonoids have a wide range of antioxidant properties. Given this background, our research was aimed at probing the effective molecular mechanism of T. polium which in turn protects the pancreatic β-cells of diabetic rats through attenuation of streptozotocin-induced oxidative stress...
July 19, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738461/-role-of-maternal-drug-use-and-environmental-exposure-during-pregnancy-and-delivery-pattern-in-allergic-infants-and-toddlers
#2
S Wang, H S Wang, J X Jiang, Y Wang, T Xu
Objective: To understand correlation between maternal drug use and environmental exposure during pregnancy and delivery pattern and allergy in infants and toddlers, and provide theoretical bases for the early prevention and intervention of infantile allergies. Methods: Case control study based on cross-sectional investigation was conducted. Thirty-three cities were selected in China. Randomly cluster sampling method was used to select a community in each city as the study sample, the women with infants aged 0-24 months were interviewed in the form of face-to-face questionnaire survey...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738407/pain-and-learning-in-primary-school-a-population-based-study
#3
Silja Kosola, Lisa K Mundy, Susan M Sawyer, Louise Canterford, Danielle A van der Windt, Kate M Dunn, George C Patton
Despite the frequency of pain among children, little is known about its effects on learning and school outcomes. The objective of this study was to quantify the association of pain and academic achievement while taking into account the presence of co-occurring emotional symptoms. A population-based stratified random sample of 1239 students aged 8 to 9 years from primary schools in Melbourne, Australia, was recruited for the Childhood to Adolescence Transition Study. Children indicated sites of pain that had lasted for a day or longer in the past month using a pain manikin...
June 21, 2017: Pain
https://www.readbyqxmd.com/read/28738374/multilevel-obstructive-sleep-apnea-surgery
#4
Hsin-Ching Lin, Edward M Weaver, Ho-Sheng Lin, Michael Friedman
Continuous positive airway pressure (CPAP) is the primary treatment of obstructive sleep apnea/hypopnea syndrome (OSA). Most sleep physicians are in agreement that a certain number of OSA patients cannot or will not use CPAP. Although other conservative therapies, such as oral appliance, sleep hygiene, and sleep positioning, may help some of these patients, there are many who fail all conservative treatments. As sleep surgeons, we have the responsibility to screen patients for both symptoms and signs of OSA...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738372/advances-in-oral-appliances-for-obstructive-sleep-apnea
#5
Ofer Jacobowitz
Oral appliances that advance the mandible are widely used as alternatives to positive airway pressure (PAP) devices or as primary therapy for obstructive sleep apnea (OSA) in adults. Although PAP is more efficacious at lowering the polysomnographic indices of OSA, the clinical effectiveness of PAP and oral appliances is similar, and patients are more likely to adhere to oral appliance therapy than to PAP treatment. Clinical examination is used to determine the candidacy of oral appliances and to select a particular appliance for a given patient...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738366/neuroanatomical-correlates-of-hypophonia-in-subcortical-vascular-cognitive-impairment
#6
Ji Hye Yoon, Yisuh Ahn, Sook Hui Kim, Juhee Chin, Seongbeom Park, Duk L Na
BACKGROUND/AIMS: Early detection and intervention may alter the disease course of subcortical vascular cognitive impairment (SVCI). Patients with SVCI have white matter ischemia that disrupts connections between the cortex and subcortical gray matter and therefore manifest various symptoms such as motor disturbances and behavioral/cognitive dysfunction. Reduced vocal loudness, or hypophonia, is one of the common motor symptoms of SVCI, but few studies have systematically investigated it in this patient population...
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28738363/mild-cognitive-impairment-and-driving-cessation-a-3-year-longitudinal-study
#7
Michael H Connors, David Ames, Michael Woodward, Henry Brodaty
BACKGROUND/AIMS: Driving cessation is associated with significant morbidity in older people. People with mild cognitive impairment (MCI) may be at particular risk of this. Very little research has examined driving in this population. Given this, we sought to identify predictors of driving cessation in people with MCI. METHODS: One hundred and eighty-five people with MCI were recruited from 9 memory clinics around Australia. People with MCI and their carers reported their driving status and completed measures of cognition, function, neuropsychiatric symptoms, and medication use at regular intervals over a 3-year period...
July 22, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28738347/negative-beliefs-about-voices-in-patients-with-borderline-personality-disorder-are-associated-with-distress-a-plea-for-cognitive-behavioural-therapy
#8
Christina W Slotema, Jan Dirk Blom, Mathijs Deen, Marieke B A Niemantsverdriet, Mark van der Gaag, Hans W Hoek, Iris E C Sommer
BACKGROUND: Auditory verbal hallucinations (AVH) are experienced by 21-54% of patients diagnosed with a borderline personality disorder (BPD), and ensuing distress is often high. Little is known about the beliefs these patients foster about their voices, and the influence thereof on distress and need for hospitalisation. METHODS: In a convenience sample of 38 BPD outpatients with AVH, data were collected with the aid of the Psychotic Symptom Rating Scales (PSYRATS), Beliefs about Voices Questionnaire (BAVQ), Social Comparison Rating Scale (SCRS), and Voice Power Differential Scale (VPDS)...
July 22, 2017: Psychopathology
https://www.readbyqxmd.com/read/28738334/time-course-of-radiological-imaging-and-variable-interindividual-symptoms-in-amyotrophic-lateral-sclerosis-and-frontotemporal-dementia-associated-with-p-arg487his-mutation-in-the-vcp%C3%A2-gene
#9
Makito Hirano, Yuko Yamagishi, Satoshi Yanagimoto, Kazumasa Saigoh, Yusaku Nakamura, Susumu Kusunoki
To our knowledge, this is the first study to report the time course of radiological imaging of 3 patients from 2 families with VCP-related amyotrophic lateral sclerosis (ALS) and dementia. Both families shared the same p.Arg487His mutation in the VCP gene encoding valosin-containing protein. The first patient started to have a typical form of ALS, followed by dementia 7 years later. The second patient, a brother of the first one, had frontotemporal dementia and parkinsonism. The third patient had simultaneous ALS and dementia...
July 24, 2017: European Neurology
https://www.readbyqxmd.com/read/28738327/updated-concepts-on-treatment-outcomes-for-obstructive-sleep-apnea
#10
Victor Certal, Robson Capasso
Obstructive sleep apnea is a highly prevalent and poorly understood condition that not only leads to significant individual patient health damage, but carries a large societal cost secondary to excessive healthcare utilization, motor-vehicle accidents, and work absenteeism. While a significant fund of knowledge about its damaging effects on the cardiovascular system and neural pathways has been gathered over the past few decades, the translation to direct patient care still presents numerous challenges. With the exception of clear issues such as socially unacceptable snoring and breathing irregularities, the exact cause and effect relationship between airway narrowing, hypoxemia, and sleep fragmentation with subjective sleep-related complaints and neurocognitive symptoms is less clear...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738299/the-impact-of-bmi-on-non-malignant-respiratory-symptoms-and-lung-function-in-arsenic-exposed-adults-of-northern-chile
#11
Anthony Nardone, Catterina Ferreccio, Johanna Acevedo, Wayne Enanoria, Alden Blair, Allan H Smith, John Balmes, Craig Steinmaus
BACKGROUND: Elevated body mass index (BMI) and arsenic are both associated with cancer and with non-malignant lung disease. Using a unique exposure situation in Northern Chile with data on lifetime arsenic exposure, we previously identified the first evidence of an interaction between arsenic and BMI for the development of lung cancer. OBJECTIVES: We examined whether there was an interaction between arsenic and BMI for the development of non-malignant lung disease...
July 21, 2017: Environmental Research
https://www.readbyqxmd.com/read/28738298/laparoscopic-treatment-of-dunbar-syndrome-a-case-report
#12
Orlando Jorge M Torres, Ozimo Pereira Gama-Filho, Camila Cristina Salazar Torres, Ricardo Mary Medeiros, Caio Márcio Barros Oliveira
BACKGROUND: Dunbar syndrome is a rare disorder due to external compression of the celiac trunk by the median arcuate ligament. The symptoms include abdominal pain, nausea and vomiting. Laparoscopic treatment was suggested as a safe procedure. The aim of this study is to present a case of Dunbar syndrome underwent laparoscopic treatment. CASEPRESENTATION: A 17-year-old female patient presented at emergency room with upper abdominal pain and dyspepsia, related to food intake...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28738296/mental-distress-quality-of-life-and-social-support-in-recurrent-ovarian-cancer-patients-during-active-chemotherapy
#13
Qiang Wen, Zhuyan Shao, Ping Zhang, Tao Zhu, Dan Li, Shihua Wang
BACKGROUND: Anxiety and depression are common sources of mental distress experienced by ovarian cancer patients. The purpose of this study was to identify changes in levels of mental distress during active chemotherapy, to characterize the impact of these changes on quality of life (QOL), and to study the potential buffering effect of social support in recurrent ovarian cancer patients. METHODS: Anxiety and depression were assessed at baseline and three months after initiation of active chemotherapy using hospital anxiety and depression scale (HADS)...
July 6, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28738293/oxytocin-effects-on-emotional-response-to-others-faces-via-serotonin-system-in-autism-a-pilot-study
#14
Mina Fukai, Tetsu Hirosawa, Mitsuru Kikuchi, Yasuomi Ouchi, Tetsuya Takahashi, Yuko Yoshimura, Yoshiaki Miyagishi, Hirotaka Kosaka, Masamichi Yokokura, Etsuji Yoshikawa, Tomoyasu Bunai, Yoshio Minabe
The oxytocin (OT)-related serotonergic system is thought to play an important role in the etiology and social symptoms of autism spectrum disorder (ASD). However, no evidence exists for the relation between the prosocial effect of chronic OT administration and the brain serotonergic system. Ten male subjects with ASD were administered OT for 8-10 weeks in an open-label, single-arm, non-randomized, uncontrolled manner. Before and during the OT treatment, positron emission tomography was used with the ((11)C)-3-amino-4-(2-[(demethylamino)methyl]phenylthio)benzonitrile((11)C-DASB) radiotracer...
June 28, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28738266/adhd-symptoms-impact-smoking-outcomes-and-withdrawal-in-response-to-varenicline-treatment-for-smoking-cessation
#15
L Cinnamon Bidwell, Hollis C Karoly, Kent E Hutchison, Angela D Bryan
INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with nicotine dependence and difficulty quitting smoking. Few cessation trials specifically consider the impact of ADHD on treatment outcomes, including those testing established pharmacological therapies, such as varenicline. METHODS: The current study focused on the impact of pretreatment ADHD inattention (IN) and hyperactivity-impulsivity (HI) symptoms on treatment outcome in a randomized controlled trial of varenicline [N=205, average age=34...
July 18, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28738234/m1-homeopathic-complex-trigger-effective-responses-against-leishmania-l-amazonensis-in-vivo-and-in-vitro
#16
Katia Fialho Nascimento, Fabiana Rodrigues de Santana, Cleber Rafael Vieira da Costa, Vanessa Kaplum, Helito Volpato, Celso Vaturo Nakamura, Leoni Villano Bonamin, Dorly de Freitas Buchi
Leishmaniasis is a term referring to a range of clinical conditions caused by protozoan parasites of the genus Leishmania, Trypanosomatidae family, Kinetoplastida order that is transmitted by the bite of certain species of mosquitoes Phlebotominae subfamily. These parasites infect hosts wild and domestic mammals, considered as natural reservoirs and can also infect humans. Leishmania are obligate intramacrophage protozoa that have exclusively intracellular life style. This suggests that the amastigotes possess mechanisms to avoid killing by host cells...
July 21, 2017: Cytokine
https://www.readbyqxmd.com/read/28738220/adolescent-peer-networks-and-the-moderating-role-of-depressive-symptoms-on-developmental-trajectories-of-cannabis-use
#17
Michael S Pollard, Joan S Tucker, Harold D Green, Kayla de la Haye, Dorothy L Espelage
This paper investigated how depressive symptoms moderate the role of peer cannabis use on developmental patterns of individual cannabis use from adolescence to young adulthood, controlling for a broad set of individual and family factors. Data from two sources were analyzed separately: two saturated schools in the National Longitudinal Study of Adolescent to Adult Health Waves I-III (N=1550) covering 1994-2001; and three schools in the CARBIN study, covering 2012-2014. Discrete mixture models identified developmental trajectories of cannabis use in each data source, and logit models linked network and depressive symptom information to the trajectories...
July 19, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28738212/the-pattern-of-self-harm-in-fars-province-in-south-iran-a-population-based-study
#18
Saeid Gholamzadeh, Mozhghan Zahmatkeshan, Mohammad Zarenezhad, Elaheh Ghaffari, Sanaz Hoseni
Non-suicidal self-harm includes cutting, scratching, burning and minor overdosing. There have been few studies that have examined the rate and pattern of self-harm among different individuals of the society. We performed a population-based study to determine different aspects of non-suicidal self-harm in cases referred to legal medicine organization of Fars Province and south Iran. In a population-based longitudinal survey, we applied data from cases referred to legal medicine organization of Fars province...
July 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28738210/neural-activity-and-emotional-processing-following-military-deployment-effects-of-mild-traumatic-brain-injury-and-posttraumatic-stress-disorder
#19
Daniel V Zuj, Kim L Felmingham, Matthew A Palmer, Ellie Lawrence-Wood, Miranda Van Hooff, Andrew J Lawrence, Richard A Bryant, Alexander C McFarlane
Posttraumatic Stress Disorder (PTSD) and mild traumatic brain injury (mTBI) are common comorbidities during military deployment that affect emotional brain processing, yet few studies have examined the independent effects of mTBI and PTSD. The purpose of this study was to examine distinct differences in neural responses to emotional faces in mTBI and PTSD. Twenty-one soldiers reporting high PTSD symptoms were compared to 21 soldiers with low symptoms, and 16 soldiers who reported mTBI-consistent injury and symptoms were compared with 16 soldiers who did not sustain an mTBI...
July 21, 2017: Brain and Cognition
https://www.readbyqxmd.com/read/28738187/presymptomatic-atrophy-in-autosomal-dominant-alzheimer-s-disease-a%C3%A2-serial-mri-study
#20
Kirsi M Kinnunen, David M Cash, Teresa Poole, Chris Frost, Tammie L S Benzinger, R Laila Ahsan, Kelvin K Leung, M Jorge Cardoso, Marc Modat, Ian B Malone, John C Morris, Randall J Bateman, Daniel S Marcus, Alison Goate, Stephen Salloway, Stephen Correia, Reisa A Sperling, Jasmeer P Chhatwal, Richard Mayeux, Adam M Brickman, Ralph N Martins, Martin R Farlow, Bernardino Ghetti, Andrew J Saykin, Clifford R Jack, Peter R Schofield, Eric McDade, Michael W Weiner, John M Ringman, Paul M Thompson, Colin L Masters, Christopher C Rowe, Martin N Rossor, Sebastien Ourselin, Nick C Fox
INTRODUCTION: Identifying at what point atrophy rates first change in Alzheimer's disease is important for informing design of presymptomatic trials. METHODS: Serial T1-weighed magnetic resonance imaging scans of 94 participants (28 noncarriers, 66 carriers) from the Dominantly Inherited Alzheimer Network were used to measure brain, ventricular, and hippocampal atrophy rates. For each structure, nonlinear mixed-effects models estimated the change-points when atrophy rates deviate from normal and the rates of change before and after this point...
July 21, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
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