keyword
https://read.qxmd.com/read/38464505/clinical-outcomes-of-patients-with-her2-positive-metastatic-breast-cancer-to-the-brain-with-first-line-trastuzumab-pertuzumab-and-chemotherapy-in-a-real-world-setting
#21
JOURNAL ARTICLE
Sarah Sharman Moser, Lior Apter, Idit Livnat, Roni Ginsburg, Adva Yarden, Michal Drori, Anat Drizon, Gabriel Chodick, Nava Siegelmann-Danieli
BACKGROUND: In this observational study, we analyzed the treatment patterns and clinical outcomes of patients with human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (mBC) who developed brain metastases during their disease in a 2.7 million-member public health-provider in Israel. METHODS: Newly diagnosed patients with mBC who initiated first-line treatment between January 2013 and June 2021 were identified. Time on treatment (ToT) and overall survival (OS) were assessed at a minimum of 6 months follow-up (cutoff: December 2021)...
2024: Breast Cancer: Targets and Therapy
https://read.qxmd.com/read/38462566/gamma-irradiation-and-ozone-application-as-preservation-methods-for-longer-term-storage-of-bee-pollen
#22
JOURNAL ARTICLE
Yahya Al Naggar, Ibrahim M Taha, El-Kazafy A Taha, Ayman Zaghlool, Ali Nasr, Ashraf Nagib, Sam M Elhamamsy, Gomaa Abolaban, Alaa Fahmy, Eslam Hegazy, Khaled H Metwaly, Abdullah A Zahra
Bee pollen is a healthy product with a good nutritional profile and therapeutic properties. Its high moisture content, however, promotes the growth of bacteria, molds, and yeast during storage commonly result in product degradation. Therefore, the aim of this study is to assess the effectiveness of gamma irradiation (GI) and ozone (OZ) as bee pollen preservation methods for longer storage time, as well as whether they are influenced by pollen species. To do that, GI at a dosage of 2.5, 5.0, and 7.5 kGy was applied at a rate of 0...
March 11, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38460585/photocatalytic-degradation-of-tetracycline-using-a-novel-wo3-zno-ac-under-visible-light-irradiation-optimization-of-effective-factors-by-rsm-ccd
#23
JOURNAL ARTICLE
Mohammad Sina Mohtaram, Samad Sabbaghi, Jamal Rasouli, Kamal Rasouli
Mitigating pharmaceutical pollution in the global environment is imperative, and tetracycline (TC) is a commonly utilized antibiotic in human and veterinary medicine. The persistent existence of TC highlights the necessity of establishing efficient measures to protect water systems and the environment from detrimental contaminants. Herein, a novel rhubarb seed waste-derived activated carbon-supported photocatalyst (WO3 -ZnO/RUAC) was synthesized by combining wet impregnation and ultrasonic methods. The activated carbon (AC) was obtained from rhubarb seed waste for the first time via chemical activation...
March 7, 2024: Environmental Pollution
https://read.qxmd.com/read/38455958/comparative-evaluation-of-antioxidant-activity-total-phenolic-content-anti-inflammatory-and-antibacterial-potential-of-euphorbia-derived-functional-products
#24
JOURNAL ARTICLE
Rania Benjamaa, Hamza Elbouny, Hajare Errati, Abdelkarim Moujanni, Neha Kaushik, Ravi Gupta, OumKeltoum Ennibi, Boubker Nasser, Eun Ha Choi, Nagendra Kumar Kaushik, Abdelkhalid Essamadi
This study assessed the medicinal properties of Euphorbia resinifera O. Berg (E. resinifera) and Euphorbia officinarum subsp echinus (Hook.f. and Coss.) Vindt ( Euphorbia echinus , known for their pharmaceutical benefits. Extracts from their flowers, stems, propolis, and honey were examined for phenolic content, antioxidant, anti-inflammatory, and antibacterial activities. Total phenolic content (TPC), total flavonoid content (TFC), and total condensed tannin (TCC) were determined using specific methods. Antioxidant potential was assessed through various tests including DPPH, FRAP, ABTS, and Total antioxidant capacity...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38455206/bioaccessibility-and-antioxidant-capacity-of-kefir-based-smoothies-fortified-with-kale-and-spinach-after-in%C3%A2-vitro-gastrointestinal-digestion
#25
JOURNAL ARTICLE
Lutfiye Yilmaz-Ersan, Tulay Ozcan, Buse Usta-Gorgun, Melike Ciniviz, Gokce Keser, Ilay Bengu, Raziye Asli Keser
The kefir-based smoothies with kale and spinach were designed as a ready-to-drink and innovative functional snack. Microbiological, physicochemical, as well as pre- and postgastrointestinal total antioxidant capacity (TAC; CUPRAC, DPPH, and FRAP) analyses were conducted. It was determined that the kefir-based smoothies with vegetables had higher ash, carbohydrate, and dietary fiber values. Fructose and glucose contents of smoothy with kale were high, while smoothy with spinach included high sucrose and maltose...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38455165/nutritional-properties-of-raw-and-cooked-azolla-caroliniana-willd-an-aquatic-wild-edible-plant
#26
JOURNAL ARTICLE
Daniel Winstead, Francesco Di Gioia, Marjorie Jauregui, Michael Jacobson
Azolla caroliniana Willd. is an understudied wild edible plant native to the Eastern United States. Other species of Azolla have been used across the world for several thousand years as a livestock feed and as "green manure." The use of Azolla for human consumption is thought to be limited by its high total polyphenolic content (TPC). However, the TPC and nutritional content of A. caroliniana has not been thoroughly studied. We measured TPC and other nutrients before and after cooking methods designed to lower TPC...
March 2024: Food Science & Nutrition
https://read.qxmd.com/read/38451630/investigation-of-phytochemical-composition-and-bioactivity-evaluation-of-extracts-from-myrsine-umbellata-mart
#27
JOURNAL ARTICLE
L V Laskoski, J M Batista, D M Bandeira, J M Corrêa, J Rosset, L H S M Conceição, F G S Pinto
The objective of the study was to carry out phytochemical prospection through colorimetric tests to determine the groups of secondary metabolites and also to determine the total content of phenolic compounds (TPC) present in plant extracts methanol (ME), ethyl acetate (EAE), hexane (HE) and dichloromethane (DE) from the leaves of Myrsine umbellata, as well as to investigate the antimicrobial activity against twelve standard ATCC strains by the broth microdilution technique; the antioxidant potential by the DPPH method and the ABTS method and the antibiofilm potential on the biofilm biomass of standard bacteria by the crystal violet technique and tetrazolium salt reduction (MTT) assay...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38450672/g-acp-a-machine-learning-approach-to-the-prediction-of-therapeutic-peptides-for-gastric-cancer
#28
JOURNAL ARTICLE
Humera Azad, Muhammad Yasir Akbar, Jawad Sarfraz, Waseem Haider, Muhammad Naeem Riaz, Ghulam Muhammad Ali, Shakira Ghazanfar
Conventional Gastrointestinal (GI) cancer treatments are quite expensive and have major hazards. Nowadays, a different strategy places more emphasis on creating tiny biologically active peptides that do not cause severe poisoning. Anticancer peptides (ACPs) are found through experimental screening, which is time-dependent and frequently fraught with difficulties. Gastric ACPs are emerging as a promising GI cancer treatment in the current day. It is crucial to identify novel gastric ACPs to have an improved knowledge of their functioning processes and treatment of gastric cancer...
March 7, 2024: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/38446779/melatonin-supplementation-enhances-browning-suppression-and-improves-transformation-efficiency-and-regeneration-of-transgenic-rough-lemon-plants-citrus-%C3%A3-jambhiri
#29
JOURNAL ARTICLE
Lamiaa M Mahmoud, Nabil Killiny, Manjul Dutt
Enzymatic browning poses a significant challenge that limits in vitro propagation and genetic transformation of plant tissues. This research focuses on investigating how adding antioxidant substances can suppress browning, leading to improved efficiency in transforming plant tissues using Agrobacterium and subsequent plant regeneration from rough lemon (Citrus × jambhiri). When epicotyl segments of rough lemon were exposed to Agrobacterium, they displayed excessive browning and tissue decay. This was notably different from the 'Hamlin' explants, which did not exhibit the same issue...
2024: PloS One
https://read.qxmd.com/read/38445688/theabrownins-in-dark-tea-form-complexes-with-tea-polysaccharide-conjugates
#30
JOURNAL ARTICLE
Chen Xiaoqiang, Mengdie Wang, Zhiyuan Wang, Xiuling Liu, Wendan Cao, Na Zhang, Yonggang Qi, Shuiyuang Cheng, Wei Huang, Zhong Liu
BACKGROUND: Theabrownins (TBs) are one of most important quality components in dark tea, but have not been produced industrially. In this study, the aqueous extract was obtained from Pu'er ripe tea, one kind of dark tea. Caffeine, theaflavin, catechin and saponin were removed by trichloromethane, ethyl acetate and n-butanol in turn to obtain TBs isolate. The TBs isolate was subjected to column chromatography using a macroporous resin HPD-750 and eluted with a gradient of 0~700 g·kg-1 ethanol aqueous solution...
March 6, 2024: Journal of the Science of Food and Agriculture
https://read.qxmd.com/read/38440159/portfolio-analysis-of-global-tobacco-control-research-funding-at-the-national-cancer-institute-2000-2019
#31
JOURNAL ARTICLE
Marie D Ricciardone, Laura Baker, Jenny Twesten, Mark Parascandola
INTRODUCTION: Research in low- and middle-income countries (LMICs), where the majority of global tobacco users reside, is critical to addressing the global tobacco epidemic. This analysis describes the global tobacco control research portfolio funded by the National Cancer Institute from fiscal years 2000 to 2019. METHODS: We used the National Institutes of Health Query, View, Report database to identify extramural grants relevant to global tobacco control research...
2024: Tobacco Prevention & Cessation
https://read.qxmd.com/read/38440065/effects-of-different-solvents-on-the-total-phenol-content-total-flavonoid-content-antioxidant-and-antifungal-activities-of-micromeria-graeca-l-from-middle-atlas-of-morocco
#32
JOURNAL ARTICLE
Fatima El Kamari, Hajar El Omari, Karima El-Mouhdi, Amina Chlouchi, Anjoud Harmouzi, Ilham Lhilali, Jihane El Amrani, Chadia Zahouani, Zouhair Hajji, Driss Ousaaid
Micromeria graeca L. is a dense chemical source of bioactive compounds such as phenolic compounds, which have various health-related properties. The current study aimed to investigate the impact of different extractor solvents on phenol and flavonoid contents, as well as the antioxidant and antifungal activities of different extracts. Initially, three extractor solvents (methanol, ethyl acetate, and water) were used to prepare the Soxhlet extracts, which were then examined for their polyphenolic content, flavonoid content, and antioxidant potential using three complementary assays (DPPH, FRAP, and TAC)...
2024: Biochemistry Research International
https://read.qxmd.com/read/38432037/the-emerging-roles-of-clathrin-mediated-endocytosis-in-plant-development-and-stress-responses
#33
REVIEW
Chi Zhang, Liang Chen, Suiwen Hou
Clathrin-mediated endocytosis (CME) is a highly conserved pathway that plays a crucial role in the endocytosis of plasma membrane proteins in eukaryotic cells. The pathway is initiated when the adaptor protein complex 2 (AP2) and TPLATE complex (TPC) work together to recognize cargo proteins and recruit clathrin. This review provides a concise overview of the functions of each subunit of AP2 and TPC, and highlights the involvement of CME in various biological processes, such as pollen development, root development, nutrient transport, extracellular signal transduction, auxin polar transport, hyperosmotic stress, salinity stress, high ammonium stress, and disease resistance...
February 2, 2024: Journal of Plant Physiology
https://read.qxmd.com/read/38430826/evaluation-of-gamma-irradiation-effects-on-antioxidant-capacity-of-propolis
#34
JOURNAL ARTICLE
Ralitsa B Mladenova, Nikolay Y Solakov, Kamelia K Loginovska
The irradiation effects on antioxidant potential and on content of phenolic compounds of propolis ethanoic extracts were studied. It was found out that gamma treatment of samples with 2 and 10 kGy had a weak decreasing effect on the total phenolic content (TPC), while no change was observed in the propolis irradiated with 5 kGy. The antiradical activity of extracts was assessed by the DPPH free radical scavenging activity evaluated by Electron Paramagnetic Resonance (EPR) spectroscopy. The EPR results were in agreement with TPC...
February 24, 2024: Applied Radiation and Isotopes
https://read.qxmd.com/read/38427658/changes-in-gc-ms-metabolite-profile-antioxidant-capacity-and-anthocyanins-content-during-fermentation-of-fine-flavor-cacao-beans-from-ecuador
#35
JOURNAL ARTICLE
Ivan Chóez-Guaranda, María Maridueña-Zavala, Adela Quevedo, María Quijano-Avilés, Patricia Manzano, Juan M Cevallos-Cevallos
The fermentation of fine-flavor cacao beans is a key process contributing to the enhancement of organoleptic attributes and monetary benefits for cacao farmers. This work aimed to describe the dynamics of the gas chromatography-mass spectrometry (GC-MS) metabolite profile as well as the antioxidant capacity and anthocyanin contents during fermentation of fine-flavor cacao beans. Samples of Nacional x Trinitario cacao beans were obtained after 0, 24, 48, 72, 96, and 120 hours of spontaneous fermentation. Total phenolic content (TPC), ferric reducing antioxidant power (FRAP), and total anthocyanin content were measured by ultraviolet-visible (UV-Vis) spectrophotometry...
2024: PloS One
https://read.qxmd.com/read/38422473/final-results-from-the-randomized-phase-iii-ascent-clinical-trial-in-metastatic-triple-negative-breast-cancer-and-association-of-outcomes-by-human-epidermal-growth-factor-receptor-2-and-trophoblast-cell-surface-antigen-2-expression
#36
JOURNAL ARTICLE
Aditya Bardia, Hope S Rugo, Sara M Tolaney, Delphine Loirat, Kevin Punie, Mafalda Oliveira, Adam Brufsky, Kevin Kalinsky, Javier Cortés, Joyce O' Shaughnessy, Véronique Diéras, Lisa A Carey, Luca Gianni, Martine Piccart-Gebhart, Sibylle Loibl, Oh Kyu Yoon, Yang Pan, Scott Hofsess, See-Chun Phan, Sara A Hurvitz
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. Sacituzumab govitecan (SG), a first-in-class anti-trophoblast cell surface antigen 2 (Trop-2) antibody-drug conjugate, demonstrated superior efficacy over single-agent chemotherapy (treatment of physician's choice [TPC]) in patients with metastatic triple-negative breast cancer (mTNBC) in the international, multicenter, phase III ASCENT study...
February 29, 2024: Journal of Clinical Oncology
https://read.qxmd.com/read/38422303/in-vitro-investigation-on-pennisetum-purpureum-leaf-extracts-grown-in-indonesia-of-phytochemical-components-optical-characteristics-and-antioxidant-antibacterial-activities
#37
JOURNAL ARTICLE
M Budiyanto, S Puspitarini, S Prasetyo, H Subekti, Y S Birhan, A Qosyim, F B Ilhami
Medicinal plants hold significant cultural significance and play a crucial role in the advancement of potentially safe drugs for the therapy of disease worldwide. Pennisetum purpureum or elephant grass has been used for traditional medications in Indonesia without understanding the phytochemicals of those plants. Herein, our report revolves around the qualitative and quantitative examination of phytochemical components, optical properties, antioxidants, and antibacterial assessments of solvent fractions derived from Pennisetum purpureum leaf...
2024: Brazilian Journal of Biology
https://read.qxmd.com/read/38414817/valorizing-assorted-logging-residues-response-surface-methodology-in-the-extraction-optimization-of-a-green-norway-spruce-needle-rich-fraction-to-obtain-valuable-bioactive-compounds
#38
JOURNAL ARTICLE
Jenni Tienaho, Marina Fidelis, Hanna Brännström, Jarkko Hellström, Magnus Rudolfsson, Atanu Kumar Das, Jaana Liimatainen, Anuj Kumar, Mika Kurkilahti, Petri Kilpeläinen
During stemwood harvesting, substantial volumes of logging residues are produced as a side stream. Nevertheless, industrially feasible processing methods supporting their use for other than energy generation purposes are scarce. Thus, the present study focuses on biorefinery processing, employing response surface methodology to optimize the pressurized extraction of industrially assorted needle-rich spruce logging residues with four solvents. Eighteen experimental points, including eight center point replicates, were used to optimize the extraction temperature (40-135 °C) and time (10-70 min)...
February 22, 2024: ACS Sustain Resour Manag
https://read.qxmd.com/read/38414781/physicochemical-and-biological-properties-of-encapsulated-boesenbergia-rotunda-extract-with-different-wall-materials-in-enhancing-antioxidant-mineralogenic-and-osteogenic-activities-of-mc3t3-e1-cells
#39
JOURNAL ARTICLE
Safiah Saah, Dalad Siriwan, Piyapat Trisonthi, Sawitree Dueramae
Boesenbergia rotunda  (L.) comprises bioactive compounds with biological and pharmacological properties, especially flavonoid compounds with osteoblastogenesis-stimulating potential. However, the application of  B. rotunda  in the food and pharmaceutical industry is restricted by its low solubility and stability. Encapsulation becomes an alternative to overcome these restrictions. The purpose study was to encapsulate  B. rotunda  extract by freeze-drying and to investigate the effects of different wall materials (maltodextrin (MD), gum arabic (GA), and their combination (MDGA)) and extract contents on the physicochemical, bioactive properties and in vitro enhancement of osteogenesis of MC3T3-E1 cells of the obtained encapsulates...
April 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38408515/phenolics-and-flavonoids-from-polygonum-posumbu-and-comparision-of-flavonoid-compounds-content-in-different-tissues-leaves-stems-and-roots
#40
JOURNAL ARTICLE
Premi Devi Pukhrambam, Khomdram Khedashwori Devi, Chingoileima Maibam, Roseeta Devi Mutum, Moirangthem Lakshmipriyari Devi, Sudripta Das
The growing global need for antioxidative phenolics and flavonoids for maintenance of human health resulted into search of new sustainable unexplored medicinal plants used by the traditional healers for various ailments. Many synthetic based products of phenolics and flavonoids have been used, however the demand of eco-friendly, natural herbal based products are increasing. As a result, the current study aims to explore traditional potential of Polygonum posumbu related to its phenolics and flavonoids. Optimization of extraction parameters were employed which includes: solvent selection (water, ethanol, methanol, acetone and ethyl acetate), ethanol composition (40-100%), solvent to sample ratio (30-70 ml/g), temperature (50-80 °C) and time (1-5 h)...
February 24, 2024: Fitoterapia
keyword
keyword
14193
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.