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https://www.readbyqxmd.com/read/28642814/lc-qtof-ms-analysis-and-activity-profiles-of-popular-antioxidant-dietary-supplements-in-terms-of-quality-control
#1
Elwira Sieniawska, Tomasz Baj, Rafal Sawicki, Aleksandra Wanat, Krzysztof Kamil Wojtanowski, Grazyna Ginalska, Grazyna Zgorka, Jolanta Szymanska
The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substantial part of the results was comparable if 1 g sample was considered, but while comparing single and daily doses, significant differences in antioxidant values were noticed in all assays...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28641205/muscilage-characterization-biochemical-and-enzymatic-activities-of-laser-irradiated-lagenaria-siceraria-seedlings
#2
Mazhar Abbas, Muhammad Arshad, Numrah Nisar, Jan Nisar, Abdul Ghaffar, Arif Nazir, M Asif Tahir, Munawar Iqbal
Laser stimulation effect on L. siceraria seed mucilage, biochemicals and enzymatic activities during early growth stages were investigated. The laser density power of 1mW/cm(2) for 3 and 5min treatments were performed and various responses i.e., seedlings mucilage, biochemical and enzymatic activities were studied. Laser treatment of L. siceraria seeds enhanced the biochemical as well as the enzymatic activities. TPC (total phenolic contents),TFC (total flavonoids contents), TSS (total soluble sugar), reducing sugar, proline contents, total soluble protein and nitrogen contents were recorded higher in laser treated groups versus control...
June 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28639693/thromboelastography-may-predict-risk-of-grade-2-bleeding-in-thrombocytopenic-patients
#3
E N Opheim, T O Apelseth, S J Stanworth, G E Eide, T Hervig
BACKGROUND AND OBJECTIVES: Platelet count is used as a prophylactic platelet transfusion trigger, although evidence suggests that it is a poor predictor of bleeding. Thus, alternative tests are required. The primary objective of this study was to compare thromboelastography (TEG) parameters on days with and without bleeding symptoms. The secondary objectives were to investigate the relationship between TEG parameters and haematological variables, fever, C-reactive protein (CRP) and platelet transfusion...
June 22, 2017: Vox Sanguinis
https://www.readbyqxmd.com/read/28631525/polyphenol-profile-by-uhplc-ms-ms-anti-glycation-antioxidant-and-cytotoxic-activities-of-several-samples-of-propolis-from-the-northeastern-semi-arid-region-of-brazil
#4
Jadriane de Almeida Xavier, Iara Barros Valentim, Fabiana O S Camatari, Alberto M M de Almeida, Henrique Fonseca Goulart, Jamylle Nunes de Souza Ferro, Emiliano de Oliveira Barreto, Bruno Coelho Cavalcanti, Carla B G Bottoli, Marília Oliveira Fonseca Goulart
CONTEXT: Propolis has promising biological activities. Propolis samples from the Northeast of Bahia, Brazil - sample A from Ribeira do Pombal and B, from Tucano - were investigated, with new information regarding their biological activities. OBJECTIVE: This paper describes the chemical profile, antioxidant, anti-glycation and cytotoxic activities of these propolis samples. MATERIAL AND METHODS: Ethanol extracts of these propolis samples (EEP) and their fractions were analyzed to determine total phenolic content (TPC); antioxidant capacity through DPPH(•), FRAP and lipid peroxidation; anti-glycation activity, by an in vitro glucose (10 mg/mL) bovine serum albumine (1 mg/mL) assay, during 7 d; cytotoxic activity on cancer (SF295, HCT-116, OVCAR-8, MDA-MB435, MX-1, MCF7, HL60, JURKAT, MOLT-4, K562, PC3, DU145) and normal cell lines (V79) at 0...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28627245/phytochemical-screening-and-in-vitro-evaluation-of-pharmacological-activities-of-peels-of-musa-sapientum-and-carica-papaya-fruit
#5
Sarmad Siddique, Shamsa Nawaz, Faqir Muhammad, Bushra Akhtar, Bilal Aslam
Aqueous, absolute and 80% ethanolic extract of fruit peels of Musa sapientum and Carica papaya were investigated for their antibacterial activity, measured by disc diffusion method and antioxidant activity, measured by four different methods. Papaya and banana peels were found to contain terpenoids, tannins, alkaloids, saponins steroid, phenols, fixed oils and fats. 80% ethanolic extract of banana peel was found to contain highest total phenolic content (TPC), total flavonoid content (TFC) and antioxidant activity but in papaya peel, highest TPC and reducing activity was shown by water extract while, TFC and radical scavenging activity was given by 80% ethanolic extract...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28616189/the-combined-effects-of-reactant-kinetics-and-enzyme-stability-explain-the-temperature-dependence-of-metabolic-rates
#6
J P DeLong, J P Gibert, T M Luhring, G Bachman, B Reed, A Neyer, K L Montooth
A mechanistic understanding of the response of metabolic rate to temperature is essential for understanding thermal ecology and metabolic adaptation. Although the Arrhenius equation has been used to describe the effects of temperature on reaction rates and metabolic traits, it does not adequately describe two aspects of the thermal performance curve (TPC) for metabolic rate-that metabolic rate is a unimodal function of temperature often with maximal values in the biologically relevant temperature range and that activation energies are temperature dependent...
June 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28614716/the-notch1-snail1-mef2c-pathway-regulates-growth-and-self-renewal-in-embryonal-rhabdomyosarcoma
#7
Myron S Ignatius, Madeline N Hayes, Riadh Lobbardi, Eleanor Y Chen, Karin M McCarthy, Prethish Sreenivas, Zainab Motala, Adam D Durbin, Aleksey Molodtsov, Sophia Reeder, Alexander Jin, Sivasish Sindiri, Brian C Beleyea, Deepak Bhere, Matthew S Alexander, Khalid Shah, Charles Keller, Corinne M Linardic, Petur G Nielsen, David Malkin, Javed Khan, David M Langenau
Tumor-propagating cells (TPCs) share self-renewal properties with normal stem cells and drive continued tumor growth. However, mechanisms regulating TPC self-renewal are largely unknown, especially in embryonal rhabdomyosarcoma (ERMS)-a common pediatric cancer of muscle. Here, we used a zebrafish transgenic model of ERMS to identify a role for intracellular NOTCH1 (ICN1) in increasing TPCs by 23-fold. ICN1 expanded TPCs by enabling the de-differentiation of zebrafish ERMS cells into self-renewing myf5+ TPCs, breaking the rigid differentiation hierarchies reported in normal muscle...
June 13, 2017: Cell Reports
https://www.readbyqxmd.com/read/28614620/a-systematic-review-of-segmental-vs-subtotal-colectomy-and-subtotal-colectomy-vs-total-proctocolectomy-for-colonic-crohn-s-disease
#8
REVIEW
Imerio Angriman, Giovanni Pirozzolo, Romeo Bardini, Francesco Cavallin, Carlo Castoro, Marco Scarpa
AIM: Surgical management of colonic Crohn's disease (CD) is still unclear because different procedures can be adopted. The choice of operation is dependent on the involvement of colonic disease but the advantages and disadvantages of the extent of resection are still debated. METHOD: The aim of the present study is to evaluate the differences in short-term and long-term outcomes of adult patients with colonic CD, who underwent either subtotal colectomy and ileorectal anastomosis (STC) or segmental colectomy (SC) or total proctocolectomy and end ileostomy (TPC)...
June 14, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28613438/uhplc-esi-hr-ms-ms-profiling-of-phenolics-from-tunisian-lycium-arabicum-boiss-antioxidant-and-anti-lipase-activities-evaluation
#9
Marwa Affes, Jawhar Fakhfakh, Ines Douad, Vincent Brieudes, Maria Halabalaki, Abdelfattah El Feki, Noureddine Allouche
This study was performed in the aim to evaluate 9 different extracts from Tunisian L. arabicum for their total phenolic (TPC) and total flavonoid (TFC) contents, phytochemical analyses as well as their antioxidant and anti-lipase activities. The in vitro antioxidant property was investigated using three complementary methods (DPPH, Ferric reducing antioxidant capacity (FRAP) and β-carotene-linoleic acid bleaching assays) while anti-lipase activity was evaluated using 4-methylumbelliferyl oleate method. From all of the tested extracts the most potent found to be the polar methanol extracts especially those of stems and leaves...
June 14, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28612382/vaccinium-meridionale-swartz-extracts-and-their-addition-in-beef-burgers-as-antioxidant-ingredient
#10
Alexis López-Padilla, Diana Martín, David Villanueva Bermejo, Laura Jaime, Alejandro Ruiz-Rodriguez, Claudia Estela Restrepo Flórez, Diana Marsela Rivero Barrios, Tiziana Fornari
BACKGROUND: Vaccinium meridionale Swartz (mortiño) constitute a source of bioactive phytochemicals, but the studies related to its efficient and green production is scarce. Pressurized liquid extraction (PLE) and ultrasound assisted extraction were compared for mortiño extraction. Total phenolic compounds (TPC) and antioxidant capacity (ABTS•+) were determined. Beef burgers with 2% of mortiño (MM) or its PLE extract (ME) were manufactured. Lipid oxidation (TBARS) and instrumental color changes were measured after refrigerated storage...
June 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28612225/prolonged-survival-in-patients-with-breast-cancer-and-a-history-of-brain-metastases-results-of-a-preplanned-subgroup-analysis-from-the-randomized-phase-iii-beacon-trial
#11
Javier Cortés, Hope S Rugo, Ahmad Awada, Chris Twelves, Edith A Perez, Seock-Ah Im, Patricia Gómez-Pardo, Lee S Schwartzberg, Veronique Diéras, Denise A Yardley, David A Potter, Audrey Mailliez, Alvaro Moreno-Aspitia, Jin-Seok Ahn, Carol Zhao, Ute Hoch, Mary Tagliaferri, Alison L Hannah, Joyce O'Shaughnessy
PURPOSE: Conventional chemotherapy has limited activity in patients with breast cancer and brain metastases (BCBM). Etirinotecan pegol (EP), a novel long-acting topoisomerase-1 inhibitor, was designed using advanced polymer technology to preferentially accumulate in tumor tissue including brain metastases, providing sustained cytotoxic SN38 levels. METHODS: The phase 3 BEACON trial enrolled 852 women with heavily pretreated locally recurrent or metastatic breast cancer between 2011 and 2013...
June 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28606862/pathogenicity-profile-of-vibrio-parahaemolyticus-in-farmed-pacific-white-shrimp-penaeus-vannamei
#12
R Ananda Raja, R Sridhar, C Balachandran, A Palanisammi, S Ramesh, K Nagarajan
A pathobiological study was conducted using Vibrio parahaemolyticus (VP) strain isolated from vibriosis affected shrimp (Penaeus vannamei) farms in Kancheepuram and Thiruvallur districts of Tamil Nadu during August 2014 to February 2015. The isolate was identified based on the morphological, physiological, biochemical and molecular characters. LD50 value with intramuscular injection was determined as 2.6 × 10(4) cfu/shrimp and sequential pathology was studied giving 6.1 × 10(3) cfu/shrimp (LD25). Total plate count (TPC) and total Vibrio count (TVC) in water, pond sediment, haemolymph, muscle, HP and gut were found significantly (P < 0...
June 9, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28604597/effect-of-light-and-dark-germination-on-the-phenolic-biosynthesis-phytochemical-profiles-and-antioxidant-activities-in-sweet-corn-zea-mays-l-sprouts
#13
Nan Xiang, Xinbo Guo, Fengyuan Liu, Quan Li, Jianguang Hu, Charles Stephen Brennan
Sweet corn is one of the most widely planted crops in China. Sprouting of grains is a new processes to increase the nutritional value of grain products. The present study explores the effects of light on the nutritional quality of sweet corn sprouts. Gene expression of phenolic biosynthesis, phytochemical profiles and antioxidant activity were studied. Two treatments (light and dark) were selected and the morphological structure of sweet corn sprouts, as well as their biochemical composition were investigated to determine the effects of light on the regulation of genes responsible for nutritional compounds...
June 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28599092/antioxidant-and-proteinase-inhibitory-activities-of-selected-poppy-papaver-somniferum-l-genotypes
#14
Erik Krošlák, Tibor Maliar, Peter Nemeček, Jana Viskupičová, Mária Maliarová, Michaela Havrlentová, Ján Kraic
Poppy seeds (Papaver somniferum L.) belong to tasty food ingredients however, they should be considered also as valuable source of biologically active compounds. Content of selected metabolites, antioxidant and proteinase inhibitory activities were analyzed in vitro in extracts from seeds of fifteen poppy genotypes. Considerable variation in all parameters was detected within the set of analyzed poppy genotypes. The genotype Major expressed the highest antioxidant activity determined by all four methodological approaches (DPPH, ABTS, FRAP, RP)...
June 9, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/28598525/retraction-an-400%C3%A2-kda-membrane-associated-complex-that-contains-one-molecule-of-the-resistance-protein-cf-4-by-susana-rivas-tatiana-mucyn-harrold-a-van-den-burg-jacques-vervoort-and-jonathan-d-g-jones
#15
(no author information available yet)
The above article, published online on 26 March 2002 in Wiley Online Library (wileyonlinelibrary.com), and in Volume 29, pp. 783-796 has been retracted by agreement between the authors, the journal Editor-in-Chief, Christoph Benning, and John Wiley & Sons Ltd. The authors have requested that it be retracted because it contains a substantial number of inappropriate image manipulations. These manipulations consist of the reuse or duplication of images, both within the above article and with another manuscript published previously in The Plant Cell (Rivas et al...
June 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28597886/photoelectrical-properties-of-cds-cdse-core-shell-qds-modified-anatase-tio2-nanowires-and-their-application-for-solar-cells
#16
Qingqing Qiu, Ping Wang, Lingling Xu, Dejun Wang, Yanhong Lin, Tengfeng Xie
Anatase TiO2 nanowire (NW) films modified with inverted type-I CdS/CdSe core/shell structure QDs have been successfully prepared by the post synthesis ligand-assisted technique. Surface photovoltage (SPV), transient photovoltage (TPV) and transient photocurrent (TPC) measurements demonstrate that CdS/CdSe core/shell structure QD-sensitized TiO2 NWs electrodes favor photoexicited electron injection and charge transfer due to the special photo-electronic features of CdS/CdSe core/shell structure QDs. With a polysulfide electrolyte, the maximum conversion efficiency was 2...
June 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28590158/relationship-between-total-polar-components-and-polycyclic-aromatic-hydrocarbons-in-fried-edible-oil
#17
Ke-Jing An, Yu-Lan Liu, Hai-Lan Liu
Deep-fried dough sticks (a Chinese traditional breakfast) were fried individually in peanut, sunflower, rapeseed, rice bran, soybean and palm oil without any time lag for 32 h (64 batches fried, each for 30 min) and fried oil samples were obtained every 2 h. The frying-induced changes in the levels of total polar compounds (TPC) and polycyclic aromatic hydrocarbons (PAHs) were investigated by edible oil polar compounds (EOPC) fast separation chromatographic system and gas chromatography-mass spectrometry (GC-MS), respectively...
June 20, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28585314/yield-quality-and-biochemical-properties-of-various-strawberry-cultivars-under-water-stress
#18
Nafiye Adak, Hamide Gubbuk, Nedim Tetik
BACKGROUND: Although strawberry (Fragaria x ananassa Duch.) species are sensitive to abiotic stress conditions, some cultivars are known to be tolerant to different environmental conditions. We examined the response of different strawberry cultivars to water stress conditions in terms of yield, quality and biochemical features. The trial was conducted under two different irrigation regimes: in grow bags containing cocopeat (control: 30%; water stress: 15% drainage) with four different cultivars (Camarosa, Albion, Amiga, and Rubygem)...
June 5, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28575860/in-vitro-and-in-vivo-anti-tumor-activity-of-alectinib-in-tumor-cells-with-ncoa4-ret
#19
Sachiko Arai, Kenji Kita, Azusa Tanimoto, Shinji Takeuchi, Koji Fukuda, Hiroshi Sato, Seiji Yano
Rearranged during transfection (RET) fusion-positive non-small cell lung cancer (NSCLC) accounts for approximately 1-2% of all NSCLCs. To date, RET fusions that involve at least six fusion partners in NSCLC, such as KIF5B, CCDC6, NCOA4, TRIM33, CLIP1, and ERC1, have been identified. Recent clinical trials for RET fusion-positive NSCLC using vandetanib or cabozantinib demonstrated positive clinical response and considerable differential activities for RET inhibitors among fusion partners. Alectinib, an approved ALK inhibitor, is reported to inhibit KIF5B-RET and CCDC6-RET...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28575805/niclosamide-induces-apoptosis-through-mitochondrial-intrinsic-pathway-and-inhibits-migration-and-invasion-in-human-thyroid-cancer-in-vitro
#20
Kai Yu, Tingting Wang, Yujue Li, Chun Wang, Xia Wang, Mei Zhang, Yongmei Xie, Shuangqing Li, Zhenmei An, Tinghong Ye
The morbidity of thyroid cancer has been rising obviously throughout the world during the past years. Classic treatment procedure is generally curable for low risk differentiated thyroid cancer, but may lead to many postoperative complications. And low-level of thyroid stimulating hormone after surgery has side effects on both cardiovascular system and skeletal system. Furthermore effective treatment approaches for more aggressive differentiated thyroid cancer, poorly differentiated thyroid cancer and anaplastic thyroid cancer are absent, thus new candidates that can inhibit tumor growth and metastasis are urgently needed...
May 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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