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https://www.readbyqxmd.com/read/28735547/nano-aramid-dressed-latex-particles-the-direct-synthesis-via-pickering-emulsion-polymerization
#1
Chunjie Xie, Teng Qiu, Jinglong Li, Heling Zhang, Xiaoyu Li, Xinlin Tuo
The direct synthesis of polymer microspheres modified by aramid nanofibers (ANF) is an interesting challenge. This work describes a simple aqueous process to prepare polystyrene (PS)/ANF composite microspheres, where the specific ANF network was "dressed" on PS. ANF was derived from the copolymerization of terephthaloyl chloride (TPC), p-phenylene diamine (PPD), and methoxypolyethylene glycol (MPEG), and could be dispersed in water stably. We applied the as-synthesized ANF as Pickering emulsifier in the o/w emulsion of styrene monomer...
July 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28733983/population-pharmacokinetics-and-exposure-response-of-trastuzumab-emtansine-in-advanced-breast-cancer-previously-treated-with-%C3%A2-2-her2-targeted-regimens
#2
Shang-Chiung Chen, Angelica Quartino, Daniel Polhamus, Matthew Riggs, Jonathan French, Xin Wang, Shweta Vadhavkar, Melanie Smitt, Silke Hoersch, Alexander Strasak, Jin Yan Jin, Sandhya Girish, Chunze Li
AIMS: We conducted population pharmacokinetic (PopPK) and exposure-response analyses for trastuzumab emtansine (T-DM1) to assess the need for T-DM1 dose optimization in patients with low exposure by using TH3RESA study data (NCT01419197). The randomized phase III TH3RESA study investigated T-DM1 vs. treatment of physician's choice (TPC) in patients with heavily pretreated HER2-positive advanced breast cancer. METHODS: We compared a historical T-DM1 PopPK model with T-DM1 pharmacokinetics in TH3RESA and performed exposure-response analyses using model-predicted cycle 1 Cmax , cycle 1 Cmin , and AUCss ...
July 21, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28731316/phytochemical-analysis-of-myrtus-communis-plant-conventional-versus-microwave-assisted-extraction-procedures
#3
Nadia Bouaoudia-Madi, Lila Boulekbache-Makhlouf, Nabil Kadri, Farid Dahmoune, Hocine Remini, Sofiane Dairi, Sonia Oukhmanou-Bensidhoum, Khodir Madani
Background Myrtle (Myrtus communis L) may constitute an interesting dietary source of health protective compounds. Microwave-assisted extraction (MAE) of total phenolic compounds (TPC) from myrtle leaf, stems, pericarp, and seeds was studied and the results were compared with those of the conventional method extraction (CME) in terms of extraction time. Methods Extraction yield/efficiency and antioxidant activity were measured using radical scavenging assay (DPPH•) and reducing power. Results The results show that the MAE was higher in terms of saving energy, extraction time (62 s) and extraction efficiency of bioactive compound compared to CME (2 h)...
June 10, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28715604/antioxidant-activities-and-phenolic-compounds-of-several-tissues-of-pawpaw-asimina-triloba-l-dunal-grown-in-korea
#4
Jin-Sik Nam, Hye-Lim Jang, Young Ha Rhee
Pawpaw (Asimina triloba [L.] Dunal) possesses antioxidant compounds and strong inhibitors of cancer cells, and is widely cultivated in North America, Canada, and Korea. We analyzed the total phenolic and total flavonoid contents (TPC and TFC, respectively) of pawpaw plants grown in Korea and the antioxidant activities of their roots, twigs, leaves, and fruit with respect to 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity, 2,2'-azino-bis diammonium salt (ABTS) radical scavenging activity, ferrous (Fe(2+) ) chelating ability, and nitrite scavenging activity...
July 17, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28708420/dose-response-effect-of-tualang-honey-on-postprandial-antioxidant-activity-and-oxidative-stress-in-female-athletes-a-pilot-study
#5
Nur Syamsina Ahmad, Azlina Abdul Aziz, Kin Weng Kong, Mohamad Shariff A Hamid, Jadeera Phaik Geok Cheong, Sareena Hanim Hamzah
OBJECTIVES: Tualang honey (TH) contains antioxidants such as ascorbic acid, phenolic acids, and flavonoids that may be protective against oxidative stress of exercise. The aim of this study was to examine the postprandial antioxidant activity and oxidative stress after ingestion of high and low dosages of TH in female athletes. MATERIALS AND METHODS: Twenty female athletes (aged 21.3 [2.1] years; body weight [BW] 54.1 [5.7] kg) were randomly assigned into two groups and consumed either 1...
July 14, 2017: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/28707612/catechin-composition-and-antioxidant-activity-of-black-teas-in-relation-to-brewing-time
#6
Wojciech Koch, Wirginia Kukula-Koch, Kazimierz Głowniak
Black tea infusions are one of the most popular beverages across the world. Their extract composition dependson several factors, brewing time being one of the most important determinants. The aim of the present study was to determine the catechin composition of different black tea infusions using a validated LC electrospray ionization time-of-flight MS method. Additionally, total phenolic content (TPC) and antioxidant activity of infusions were evaluated using Folin–Ciocalteu reagent and stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH)...
July 13, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28702121/occurrence-of-femoral-nerve-injury-among-patients-undergoing-transfemoral-percutaneous-catheterization-procedures-in-the-united-states
#7
Mohammad El-Ghanem, Ahmed A Malik, Andre Azzam, Hussam A Yacoub, Adnan I Qureshi, Nizar Souayah
BACKGROUND: The proximity of the femoral nerve to the femoral artery renders it vulnerable to injury during transfemoral percutaneous catheterization (TPC) procedures. OBJECTIVE: To determine the incidence of femoral nerve injury in patients undergoing cardiac catheterization in a nationally representative inpatient database. METHODS: We analyzed data released annually from the Nationwide Inpatient Sample. We pooled data from 2002 to 2010 and, using the ICD-9-CM procedure codes, identified patients who underwent TPC...
June 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/28701658/drosophila-dock-family-protein-zizimin-involves-in-pigment-cell-differentiation-in-pupal-retinae
#8
Fumito Ozasa, Kazushige Morishita, Ngoc Anh Suong Dang, Seiji Miyata, Hideki Yoshida, Masamitsu Yamaguchi
The dedicator of cytokinesis (DOCK) family proteins are known as one of guanine nucleotide exchange factors (GEFs), that contribute to cellular signaling processes by activating small G proteins. Although mammalian Zizimin is known to be a GEF for Cdc42 of Rho family small GTPase, its role in vivo is not well understood. Here we studied in vivo function of Drosophila Zizimin (Ziz). Knockdown of Ziz in eye imaginal discs induced the rough eye phenotype accompanied with fusion of ommatidia, loss of bristles and loss of pigments...
July 13, 2017: Cell Structure and Function
https://www.readbyqxmd.com/read/28677745/galectin-1-is-a-diagnostic-marker-involved-in-thyroid-cancer-progression
#9
Vanessa Arcolia, Fabrice Journe, Aurore Wattier, Emmanuelle Leteurtre, Florence Renaud, Hans-Joachim Gabius, Myriam Remmelink, Christine Decaestecker, Alexandra Rodriguez, Sébastien Boutry, Sophie Laurent, Sven Saussez
Fine-needle aspiration (FNA) is the most commonly used pre-operative technique for diagnosis of malignant thyroid tumor. However, many benign lesions, with indeterminate diagnosis following FNA, are referred to surgery. Based on multifunctionality of the endogenous galectin-1, we aimed to assess its status for early diagnosis of thyroid cancer. Immunohistochemistry for galectin-1 and -3 was performed on a clinical series of 69 cases of thyroid lesions. Galectin-1 expression was further examined in two additional tissue microarrays (TMA) composed of 66 follicular adenomas and 66 papillary carcinomas in comparison to galectin-3 and cytokeratin-19 (CK19)...
July 4, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28672807/solvent-free-microwave-assisted-extraction-of-polyphenols-from-olive-tree-leaves-antioxidant-and-antimicrobial-properties
#10
Selin Şahin, Ruya Samli, Ayşe Seher Birteksöz Tan, Francisco J Barba, Farid Chemat, Giancarlo Cravotto, José M Lorenzo
Response surface methodology (RSM) and artificial neural networks (ANN) were evaluated and compared in order to decide which method was the most appropriate to predict and optimize total phenolic content (TPC) and oleuropein yields in olive tree leaf (Oleaeuropaea) extracts, obtained after solvent-free microwave-assisted extraction (SFMAE). The SFMAE processing conditions were: microwave irradiation power 250-350 W, extraction time 2-3 min, and the amount of sample 5-10 g. Furthermore, the antioxidant and antimicrobial activities of the olive leaf extracts, obtained under optimal extraction conditions, were assessed by several in vitro assays...
June 24, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28672789/evaluating-modern-techniques-for-the-extraction-and-characterisation-of-sunflower-hellianthus-annus-l-seeds-phenolics
#11
Panagiotis Zoumpoulakis, Vassilia J Sinanoglou, Eleni Siapi, George Heropoulos, Charalampos Proestos
Recently there is a great interest in using high energy techniques (HET) which involve microwave or ultrasound-assisted extraction (MAE and UAE) for isolation of natural bioactive compounds from plant foods. Such bioactive compounds are phenolics which were determined from sunflower (Helianthus annuus L.) kernels and hulls (defatted) utilising two different high energy extraction techniques, ultrasound and microwave assisted solvent extraction. All samples were characterised by ultra-high-performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS)...
June 24, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/28670916/gamma-irradiation-affects-the-total-phenol-anthocyanin-and-antioxidant-properties-in-three-different-persian-pistachio-nuts
#12
Mohammad Akbari, Mostafa Farajpour, Mostafa Aalifar, Mohammad Sadat Hosseini
The effects of gamma irradiation (GR) on total phenol, anthocyanin and antioxidant activity were investigated in three different Persian pistachio nuts at doses of 0, 1, 2 and 4 kGy. The antioxidant activity, as determined by FRAP and DPPH methods, revealed a significant increase in the 1-2 kGy dose range. Total phenol content (TPC) revealed a similar pattern or increase in this range. However, when radiation was increased to 4 kGy, TPC in all genotypes decreased. A radiation dose of 1 kGy had no significant effect on anthocyanin content of Kale-Ghouchi (K) and Akbari (A) genotypes, while it significantly increased the anthocyanin content in the Ghazvini (G) genotype...
July 3, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28665341/chemical-composition-antibacterial-and-antifungal-activities-of-crude-dittrichia-viscosa-l-greuter-leaf-extracts
#13
Wafa Rhimi, Issam Ben Salem, Davide Immediato, Mouldi Saidi, Abdennacer Boulila, Claudia Cafarchia
The small amount of data regarding the antifungal activity of Dittrichia viscosa (L.) Greuter against dermatophytes, Malassezia spp. and Aspergillus spp., associated with the few comparative studies on the antimicrobial activity of methanolic, ethanolic, and butanolic extracts underpins the study herein presented. The total condensed tannin (TCT), phenol (TPC), flavonoid (TFC), and caffeoylquinic acid (CQC) content of methanol, butanol, and ethanol (80% and 100%) extracts of D. viscosa were assessed and their bactericidal and fungicidal activities were evaluated...
June 30, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28663685/variable-selection-via-partial-correlation
#14
Runze Li, Jingyuan Liu, Lejia Lou
Partial correlation based variable selection method was proposed for normal linear regression models by Bühlmann, Kalisch and Maathuis (2010) as a comparable alternative method to regularization methods for variable selection. This paper addresses two important issues related to partial correlation based variable selection method: (a) whether this method is sensitive to normality assumption, and (b) whether this method is valid when the dimension of predictor increases in an exponential rate of the sample size...
July 2017: Statistica Sinica
https://www.readbyqxmd.com/read/28662571/scaling-from-metabolism-to-population-growth-rate-to-understand-how-acclimation-temperature-alters-thermal-performance
#15
Thomas M Luhring, John P DeLong
The mean and variance of environmental temperature are changing as a consequence of human activities. Ectotherms are sensitive to these temperature changes in the short term, typically displaying a unimodal response of most biological rates to temperature (thermal performance curves; TPCs). Many organisms, however, may acclimate or evolve in response to new temperature regimes. In particular, population growth rate TPCs (r TPCs) reflect the ability to maintain positive growth under a range of temperatures, and therefore shifts in r TPCs due to acclimation are fundamental to our understanding of how ectotherms will respond to changes in climate...
June 28, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28660460/bioactive-profile-free-radical-scavenging-potential-dna-damage-protection-activity-and-mycochemicals-in-aspergillus-awamori-mtcc-548-extracts-a-novel-report-on-filamentous-fungi
#16
Raj Kumar Salar, Sukhvinder Singh Purewal, Kawaljit Singh Sandhu
Biomass of Aspergillus awamori was investigated for mycochemicals, total phenolic compounds (TPC), condensed tannin content (CTC), free-radical scavenging potential (FRSP), and DNA damage protection activity. FRSP was determined using DPPH, ABTS, FRAP (Ferric reducing antioxidant power), metal chelating activity, and cupric reducing antioxidant capacity) assays. Water (Aq), aqueous ethanol 50% (AqE), and methanol were used as extraction phase at 44.5 °C for 23.8 min. AqE shows the presence of maximum mycochemicals (coumarins, glucose, saponins, flavonoids, and tannin)...
July 2017: 3 Biotech
https://www.readbyqxmd.com/read/28656706/on-the-structure-and-mechanism-of-two-pore-channels
#17
REVIEW
Alexander F Kintzer, Robert M Stroud
In eukaryotes, two-pore channels (TPC1-3) comprise a family of ion channels that regulate the conductance of Na(+) and Ca(2+) ions across cellular membranes. TPC1-3 form endolysosomal channels, but TPC3 can also function in the plasma membrane. TPC1/3 are voltage-gated channels, but TPC2 opens in response to binding endolysosome-specific lipid phosphatidylinositol-3,5-diphosphate (PI(3,5)P2 ). Filoviruses, such as Ebola, exploit TPC-mediated ion release as a means of escape from the endolysosome during infection...
June 28, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28653913/evaluation-of-anti-oxidative-antimicrobial-and-anti-diabetic-potential-of-adiantum-venustum-and-identification-of-its-phytochemicals-through-gc-ms
#18
Javerya Hamid, Dildar Ahmed, Abdul Waheed
The present study aimed to explore antioxidant, antimicrobial and anti-diabetic properties of the fern Adiantum venustum. The TPC (total phenolic content) of methanolic extract of the plant was 247.95±0.0007μg of Gallic acid equivalents per gram of dried extract (mg GAE/g). The highest TPC was in n-butanolic fraction, which was 981.45±0.1562mg GAE/g. Hexane fraction showed lowest TPC (256.95±0.0420mg GAE/g). Ethyl acetate fraction exhibited highest total flavonoid content (TFC), i.e., 62.0±0.050mg of Rutin equivalents per gram of sample...
May 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28642814/lc-qtof-ms-analysis-and-activity-profiles-of-popular-antioxidant-dietary-supplements-in-terms-of-quality-control
#19
Elwira Sieniawska, Tomasz Baj, Rafal Sawicki, Aleksandra Wanat, Krzysztof Kamil Wojtanowski, Grazyna Ginalska, Grazyna Zgorka, Jolanta Szymanska
The dietary supplements with claimed antioxidant activity constitute a substantial part of the dietary supplement market. In this study, we performed the LC-QTOF-MS analysis and investigated the activity profiles of popular antioxidant dietary supplements from different chemical groups in terms of quality control. The commonly used antioxidant tests and statistical analysis revealed that substantial part of the results was comparable if 1 g sample was considered, but while comparing single and daily doses, significant differences in antioxidant values were noticed in all assays...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28641205/muscilage-characterization-biochemical-and-enzymatic-activities-of-laser-irradiated-lagenaria-siceraria-seedlings
#20
Mazhar Abbas, Muhammad Arshad, Numrah Nisar, Jan Nisar, Abdul Ghaffar, Arif Nazir, M Asif Tahir, Munawar Iqbal
Laser stimulation effect on L. siceraria seed mucilage, biochemicals and enzymatic activities during early growth stages were investigated. The laser density power of 1mW/cm(2) for 3 and 5min treatments were performed and various responses i.e., seedlings mucilage, biochemical and enzymatic activities were studied. Laser treatment of L. siceraria seeds enhanced the biochemical as well as the enzymatic activities. TPC (total phenolic contents),TFC (total flavonoids contents), TSS (total soluble sugar), reducing sugar, proline contents, total soluble protein and nitrogen contents were recorded higher in laser treated groups versus control...
June 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
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