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https://www.readbyqxmd.com/read/28335220/pde5-inhibitors-loaded-nanovesicles-physico-chemical-properties-and-in-vitro-antiproliferative-activity
#1
Roberta F De Rose, Maria Chiara Cristiano, Marilena Celano, Valentina Maggisano, Ada Vero, Giovanni Enrico Lombardo, Martina Di Francesco, Donatella Paolino, Diego Russo, Donato Cosco
Novel therapeutic approaches are required for the less differentiated thyroid cancers which are non-responsive to the current treatment. In this study we tested an innovative formulation of nanoliposomes containing sildenafil citrate or tadalafil, phosphodiesterase-5 inhibitors, on two human thyroid cancer cell lines (TPC-1 and BCPAP). Nanoliposomes were prepared by the thin layer evaporation and extrusion methods, solubilizing the hydrophilic compound sildenafil citrate in the aqueous phase during the hydration step and dissolving the lipophilic tadalafil in the organic phase...
May 18, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334650/ultrasensitive-determination-of-dna-oxidation-products-by-gas-chromatography-tandem-mass-spectrometry-and-the-role-of-antioxidants-in-the-prevention-of-oxidative-damage
#2
Sam Dawbaa, Önder Aybastıer, Cevdet Demir
Oxidative stress is considered as one of the significant causes of DNA damage which in turn contributes to cell death through a series of intermediate processes such as cancer formation, mutation, and aging. Natural sources such as plant and fruit products have provided us with interesting substances of antioxidant activity that could be recruited in protecting the genetic materials of the cells. This study is an effort to discover some of those antioxidants effects in their standard and natural forms by performing an ultrasensitive determination of the products of DNA oxidation using GC-MS/MS...
March 16, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28317769/protective-ability-against-oxidative-stress-of-brewers-spent-grain-protein-hydrolysates
#3
Elsa F Vieira, Diana Dias da Silva, Helena Carmo, Isabel M P L V O Ferreira
The protein fraction of Brewers' spent grain (BSG) was used as substrate to obtain hydrolysates with antioxidant activity. Three enzymatic approaches were applied: brewer's spent yeast (BSY) proteases, Neutrase® and Alcalase®, at the same proteolytic activity (1U/mL), using an enzyme/substrate ratio of 10:100 (v/v), at 50°C, 4h. Total Phenolic Content (TPC) and Ferric Ion Reducing Antioxidant Power (FRAP) of hydrolysates and fractions <10kDa and <3kDa were assayed. Additionally, the protective ability of <10kDa fractions against oxidative stress on Caco-2 and HepG2 cells was investigated...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28317754/first-report-on-isolation-of-2-3-4-trihydroxy-5-methylacetophenone-from-palmyra-palm-borassus-flabellifer-linn-syrup-its-antioxidant-and-antimicrobial-properties
#4
M V Reshma, Jubi Jacob, V L Syamnath, V P Habeeba, B S Dileep Kumar, Ravi S Lankalapalli
The first report on isolation and characterization of 2,3,4-trihydroxy-5-methylacetophenone (1), nicotinamide (2), and uracil (3) from palmyra palm syrup is described. Total phenolic content (TPC) and Total flavonoid content (TFC) of palm syrup were 244.70±5.77(mggallic acid/kg of syrup) and 658.45±27.86(mg quercetin/kg of syrup), respectively. Compound 1 exhibited DPPH radical scavenging activity with an IC50 value of 20.02±0.14μM which was better than ascorbic acid (IC50=22.59±0.30μM). Compound 1 also showed broad spectrum antibacterial activity against Escherichia coli, Mycobacterium smegmatis, Staphylococcus aureus and Staphylococcus simulans...
August 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28303053/comparison-of-color-anti-nutritional-factors-minerals-phenolic-profile-and-protein-digestibility-between-hard-to-cook-and-easy-to-cook-grains-from-different-kidney-bean-phaseolus-vulgaris-accessions
#5
Naincy Parmar, Narpinder Singh, Amritpal Kaur, Sheetal Thakur
The present study was aimed to evaluate the differences among anti-nutritional factors in relation to mineral absorption and protein digestibility of Easy-to-cook (ETC) and Hard-to-cook (HTC) grains from different kidney bean (KB) accessions.HTC grains showed lower a* (redness to yellowness) and b* (greenness to blueness) values and L* value than ETC grains. HTC grains had significantly higher Ca and Zn and lower Cu, Mn and Fe than ETC grains. ETC and HTC grains showed significant variation in mineral, total phenolic content (TPC), tannin and phytic acid content...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28303046/antioxidant-activity-and-polyphenolic-compound-stability-of-lentil-orange-peel-powder-blend-in-an-extrusion-process
#6
Rahul P Rathod, Uday S Annapure
Lentil contains substantial amount of protein, carbohydrate, fibre and other nutrients and orange peels powder rich in carbohydrate and fiber content The present study was aimed to investigate the effects of extrusion processing parameter on the level of total phenolic content (TPC), total flavonoid content (TFC), total tannin content and antioxidant activity of lentil-orange peel powder blend, also to investigate the possibility of blend as a candidate for production of protein rich extruded product by using response surface methodology...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28303043/ultrasound-assisted-extraction-of-polyphenols-and-their-distribution-in-whole-mung-bean-hull-and-cotyledon
#7
Barinderjit Singh, Narpinder Singh, Sheetal Thakur, Amritpal Kaur
In this study, extraction of polyphenols using different solvents (acetone, ethanol, methanol and water) with ultrasound and conventional method from whole mung bean (WMB), hull and cotyledon was conducted. Total phenolic content (TPC), total flavonoids content (TFC), total antioxidant activities (TAA), ferric reducing power (FRP) and DPPH radical scavenging activity were determined. Ultrasound treated extracts exhibited higher TPC, TFC, TAA, FRP and DPPH in different mung bean fractions than CSE. Among the solvents, acetone showed better TPC, TFC, TAA, FRP and DPPH...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28277188/knockdown-of-sox9-inhibits-the-proliferation-invasion-and-emt-in-thyroid-cancer-cells
#8
Jie Huang, Li Guo
Sex-determining region Y (SRY)-box 9 (SOX9) is a member of the SOX transcription factor family. Increasing evidence has reported that SOX9 plays different roles in various types of malignancies. However, the role of SOX9 in papillary thyroid cancer (PTC) is still unclear. The aim of this study was to investigate the role of SOX9 in PTC. Our results showed that SOX9 was upregulated in PTC tissues and cell lines. In addition, knockdown of SOX9 significantly inhibited PTC proliferation, colony formation, migration, and invasion, as well as epithelial-mesenchymal transition (EMT) phenotype in TPC-1 and BCPAP cells...
January 26, 2017: Oncology Research
https://www.readbyqxmd.com/read/28274442/development-of-predictive-models-for-total-phenolics-and-free-p-coumaric-acid-contents-in-barley-grain-by-near-infrared-spectroscopy
#9
Zhigang Han, Shengguan Cai, Xuelei Zhang, Qiufeng Qian, Yuqing Huang, Fei Dai, Guoping Zhang
Barley grains are rich in phenolic compounds, which are associated with reduced risk of chronic diseases. Development of barley cultivars with high phenolic acid content has become one of the main objectives in breeding programs. A rapid and accurate method for measuring phenolic compounds would be helpful for crop breeding. We developed predictive models for both total phenolics (TPC) and p-coumaric acid (PA), based on near-infrared spectroscopy (NIRS) analysis. Regressions of partial least squares (PLS) and least squares support vector machine (LS-SVM) were compared for improving the models, and Monte Carlo-Uninformative Variable Elimination (MC-UVE) was applied to select informative wavelengths...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28274408/vacuum-infiltration-of-putrescine-enhances-bioactive-compounds-and-maintains-quality-of-blood-orange-during-cold-storage
#10
Fariborz Habibi, Asghar Ramezanian
The effects of putrescine (Put) treatment on anthocyanin concentrations and other bioactive compounds of two blood orange ('Moro' and 'Tarocco') cultivars during cold storage have been investigated. Put at 0, 1 and 2mM were applied to fruit by vacuum infiltration at 26.665kPa for 8min and then stored at 5°C, and 90% RH for 60days, plus a simulated shelf life of 2days at 20°C. Put treatment maintained higher fruit firmness and reduced weight loss during storage. Anthocyanin, total phenolic content (TPC), ascorbic acid content, and antioxidant activity were also higher in treated fruit than the control during storage...
July 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28272313/optimization-of-ultrasonic-assisted-enzymatic-extraction-conditions-for-improving-total-phenolic-content-antioxidant-and-antitumor-activities-in-vitro-from-trapa-quadrispinosa-roxb-residues
#11
Feng Li, Yi-Dan Mao, Yi-Fan Wang, Aun Raza, Li-Peng Qiu, Xiu-Quan Xu
Stems are the important residues of Trapa quadrispinosa Roxb., which are abundant in phenolic compounds. Ultrasonic-assisted enzymatic extraction (UAEE) is confirmed as a novel extraction technology with main advantages of enhancing extraction yield and physiological activities of the extracts from various plants. In this study, UAEE was applied to obtain the highest yield of phenolic content, strongest antioxidant, and antitumor activities and to optimize the extraction conditions using response surface methodology (RSM)...
March 6, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28270853/potential-antitumor-effect-of-harmine-in-the-treatment-of-thyroid-cancer
#12
Shu Ruan, Feng Jia, Jianbo Li
Thyroid cancer is one of the most common types of cancer in endocrine system. In latest studies, harmine has been proved to inhibit the growth of several cancers in vitro and in vivo. In the current study, we evaluated the in vitro and in vivo anticancer efficiency of harmine against thyroid cancer cell line TPC-1. The in vitro cytotoxicity of harmine evaluated by XTT assay indicated that harmine suppressed the proliferation of TPC-1 cells in a dose- and time-dependent manner. Moreover, harmine dose-dependently induced apoptosis of TPC-1 cells through regulating the ratio of Bcl-2/Bax...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28265769/curcumin-induces-g2-m-arrest-apoptosis-nf-%C3%AE%C2%BAb-inhibition-and-expression-of-differentiation-genes-in-thyroid-carcinoma-cells
#13
Suzan Schwertheim, Frederik Wein, Klaus Lennartz, Karl Worm, Kurt Werner Schmid, Sien-Yi Sheu-Grabellus
PURPOSE: The therapy of unresectable advanced thyroid carcinomas shows unfavorable outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently contributes to therapeutic resistance; the radioiodine therapy often fails due to the loss of differentiated functions in advanced thyroid carcinomas. Curcumin is known for its anticancer properties in a series of cancers, but only few studies have focused on thyroid cancer. Our aim was to evaluate curcumin's molecular mechanisms and to estimate if curcumin could be a new therapeutic option in advanced thyroid cancer...
March 6, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28265361/stabilization-of-sunflower-oil-with-pussy-willow-salix-aegyptiaca-extract-and-essential-oil
#14
Zahra Sayyari, Reza Farahmandfar
The aim of present study was to evaluate antioxidant efficacy of pussy willow extract (PWE) and essential oil (PWEO) in stabilization of sunflower oil (SFO) during ambient storage (60 days at 25°C). Initially, total phenolic (TP) and total flavonoid (TF) contents were evaluated. Then, PWE, PWEO, and TBHQ were added to SFO. Peroxide value (PV), carbonyl value (CV), total polar compound (TPC), acid value (AV), and Oxidative stability index (OSI) were measured every 15 days. The results showed that PWE had higher TP and TF than PWEO (TP: 966...
March 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28265357/antioxidant-potential-of-juglans-nigra-black-walnut-husks-extracted-using-supercritical-carbon-dioxide-with-an-ethanol-modifier
#15
Jonathan Wenzel, Cheryl Storer Samaniego, Lihua Wang, Laron Burrows, Evan Tucker, Nathan Dwarshuis, Michelle Ammerman, Ali Zand
The black walnut, Junglas nigra, is indigenous to eastern North America, and abscission of its fruit occurs around October. The fruit consists of a husk, a hard shell, and kernel. The husk is commonly discarded in processing, though it contains phenolic compounds that exhibit antioxidant and antimicrobial properties. For this study, black walnut husks were extracted using supercritical carbon dioxide with an ethanol modifier. The effects of temperature, ethanol concentration, and drying of walnut husks prior to extraction upon antioxidant potential were evaluated using a factorial design of experiments...
March 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28259821/inhibition-of-mapkinase-pathway-sensitizes-thyroid-cancer-cells-to-abt-737-induced-apoptosis
#16
Viswanath Gunda, Kristopher A Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parangi
Bcl2 family proteins play an important role in the resistance of thyroid cancer cells to apoptosis induced by chemotherapeutic drugs and targeted therapies. BH3-profiling of seven fresh primary papillary thyroid cancer (PTC) tumors showed dependence for survival on Bcl-xL (2/7), Bcl2 (2/7), and Mcl-1 (2/7), while the majority of thyroid cell lines were mainly dependent on Bcl-xL. Targeting Bcl2 family proteins with the BH3 mimetic, ABT-737, while simultaneously inhibiting ERK pathway proteins with PLX4720 and PD325901 was shown to induce significantly high apoptosis in the majority of cell lines (8505c, SW1736, HTh7, BCPAP) and moderate apoptosis in the TPC-1 cell line...
March 1, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28257062/antioxidant-activity-of-the-lignins-derived-from-fluidized-bed-fast-pyrolysis
#17
Sohail S Qazi, Dongbing Li, Cedric Briens, Franco Berruti, Mamdouh M Abou-Zaid
A challenge in recent years has been the rational use of forest and agriculture residues for the production of bio-fuel, biochemical, and other bioproducts. In this study, potentially useful compounds from pyrolytic lignins were identified by HPLC-MS/MS and untargeted metabolomics. The metabolites identified were 2-(4-allyl-2-methoxyphenoxy)-1-(4-hydroxy-3-methoxyphenyl)-1-propanol, benzyl benzoate, fisetinidol, phenyllactic acid, 2-phenylpropionic acid, 6,3'-dimethoxyflavone, and vanillin. The 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity (DPPH), trolox equivalent antioxidant capacity (TEAC), and total phenolics content (TPC) per gram of pyrolytic lignin ranged from 14 to 503 mg ascorbic acid equivalents, 35 to 277 mg trolox equivalents, and 0...
March 1, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28252354/microbiological-quality-of-raw-milk-attributable-to-prolonged-refrigeration-conditions
#18
Nuwan R Vithanage, Muditha Dissanayake, Greg Bolge, Enzo A Palombo, Thomas R Yeager, Nivedita Datta
Refrigerated storage of raw milk is a prerequisite in dairy industry. However, temperature abused conditions in the farming and processing environments can significantly affect the microbiological quality of raw milk. Thus, the present study investigated the effect of different refrigeration conditions such as 2, 4, 6, 8, 10 and 12 °C on microbiological quality of raw milk from three different dairy farms with significantly different initial microbial counts. The bacterial counts (BC), protease activity (PA), proteolysis (PL) and microbial diversity in raw milk were determined during storage...
February 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28252105/the-human-two-pore-channel-1-is-modulated-by-cytosolic-and-luminal-calcium
#19
Laura Lagostena, Margherita Festa, Michael Pusch, Armando Carpaneto
Two-pore channels (TPC) are intracellular endo-lysosomal proteins with only recently emerging roles in organellar signalling and involvement in severe human diseases. Here, we investigated the functional properties of human TPC1 expressed in TPC-free vacuoles from Arabidopsis thaliana cells. Large (20 pA/pF) TPC1 currents were elicited by cytosolic addition of the phosphoinositide phosphatidylinositol-(3,5)-bisphosphate (PI(3,5)P2) with an apparent binding constant of ~15 nM. The channel is voltage-dependent, activating at positive potentials with single exponential kinetics and currents are Na(+) selective, with measurable but low permeability to Ca(2+)...
March 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28251647/changes-of-the-phenolic-compounds-and-antioxidant-activities-in-germinated-adlay-seeds
#20
Lei Xu, Pei Wang, Barkat Ali, Na Yang, Yisheng Chen, Fengfeng Wu, Xueming Xu
BACKGROUND: Over the years, germinated adlay products have been used as both food source and folk medicine. This study investigated the changes of total phenolic content (TPC), total flavonoid content (TFC), antioxidant activities, and phenolic acid profiles of adlay seed during germination. RESULTS: Results revealed that phenolic compounds and antioxidant activities varied with the germination stages. Germination significantly increased the free form phenolic and flavonoid contents by 112...
March 2, 2017: Journal of the Science of Food and Agriculture
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