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https://www.readbyqxmd.com/read/28231159/comparison-of-the-proximate-composition-total-carotenoids-and-total-polyphenol-content-of-nine-orange-fleshed-sweet-potato-varieties-grown-in-bangladesh
#1
Mohammad Khairul Alam, Ziaul Hasan Rana, Sheikh Nazrul Islam
In an attempt to develop the food composition table for Bangladesh, the nutritional composition of nine varieties of orange-fleshed sweet potato was analyzed together with total carotenoids (TCC) and total polyphenol content (TPC). Each variety showed significant variation in different nutrient contents. The quantification of the TCC and TPC was done by spectrophotometric measurement, and the proximate composition was done by the AOAC method. The obtained results showed that total polyphenol content varied from 94...
September 14, 2016: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/28223936/two-pore-channels-catalyzers-of-endolysosomal-transport-and-function
#2
REVIEW
Christian Grimm, Cheng-Chang Chen, Christian Wahl-Schott, Martin Biel
Two-pore channels (TPCs) have recently emerged as a novel class of non-selective cation channels in the endolysosomal system. There are two members in the human genome, TPC1 and TPC2. Studies with TPC knockout and knockdown models have revealed that these channels participate in the regulation of multiple endolysosomal trafficking pathways which when dysregulated can lead to or influence the development of a range of different diseases such as lysosomal storage, metabolic, or infectious diseases. TPCs have been demonstrated to be activated by different endogenous stimuli, PI(3,5)P2 and NAADP, and ATP has been found to block TPC activation via mTOR...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28219296/phytochemical-screening-and-evaluation-of-in-vitro-antioxidant-and-antimicrobial-activities-of-the-indigenous-medicinal-plant-albizia-odoratissima
#3
Venkanna Banothu, Chandrasekharnath Neelagiri, Uma Adepally, Jayalakshmi Lingam, Kesavaharshini Bommareddy
CONTEXT: Albizia odoratissima (L. f.) Benth has been used in Indian folk medicine to treat numerous inflammatory pathologies, such as leprosy, ulcers, burns and asthma. OBJECTIVE: To evaluate the antioxidant and antimicrobial properties of A. odoratissima. MATERIALS AND METHODS: Dried leaves of A. odoratissima were extracted in organic solvents (hexane, chloroform, ethyl acetate, and methanol). The total phenolic content (TPC) and total flavonoid content (TFC) were determined using the Folin-Ciocalteu and aluminum chloride colorimetric methods, respectively...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28216882/anticancer-potential-of-nutraceutical-formulations-in-mnu-induced-mammary-cancer-in-sprague-dawley-rats
#4
Gummalla Pitchaiah, Annapurna Akula, Vishala Chandi
BACKGROUND: Nutraceuticals help in combating some of the major health problems of the century including cancer, and 'nutraceutical formulations' have led to the new era of medicine and health. OBJECTIVE: To develop different nutraceutical formulations and to assess the anticancer potential of nutraceutical formulations in N-methyl-N-nitrosourea (MNU)-induced mammary cancer in Sprague Dawley rats. MATERIALS AND METHODS: Different nutraceutical formulations were prepared using fine powders of amla, apple, garlic, onion, papaya, turmeric, and wheat grass with and without cow urine distillate...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28187689/evaluation-of-antihypertensive-potential-of-ficus-carica-fruit
#5
Alamgeer, Shifa Iman, Hira Asif, Muhammad Saleem
CONTEXT: Ficus carica L. (Moraceae) fruit is said to possess cardiovascular activity and has been used empirically in traditional phytotherapies for the treatment of hypertension and various other cardiovascular diseases. OBJECTIVE: This study investigated the antihypertensive and cardioinhibitory activity of the aqueous-methanol extract of F. carica fruit in rats. MATERIALS AND METHODS: Extract in 250, 500 and 1000 mg/kg doses (p.o.) were administered to normotensive Sprague Dawley rats and blood pressure was measured using non-invasive technique...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28177054/propolis-from-southwest-of-parana-produced-by-selected-bees-influence-of-seasonality-and-food-supplementation-on-antioxidant-activity-and-phenolic-profile
#6
Matheus A Calegari, Anaclara Prasniewski, Cleidiane DA Silva, Ricardo Y Sado, Fabiana M C Maia, Larissa M S Tonial, Tatiane L C Oldoni
Propolis produced by selected bees Apis mellifera were collected from March to June of 2013 and in March of 2015 and analyzed in order to evaluate the influence of climate, colony of origin, and food supplementation of colonies on the content of total phenolic and flavonoid by chromatographic analysis and antioxidant activity by radical scavenging of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) methods...
February 6, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28165019/fungal-endophyte-derived-fritillaria-unibracteata-var-wabuensis-diversity-antioxidant-capacities-in-vitro-and-relations-to-phenolic-flavonoid-or-saponin-compounds
#7
Feng Pan, Tian-Jiao Su, Shi-Mei Cai, Wei Wu
Diverse fungal endophytes are rich fungal resources for the production of an enormous quantity of natural products. In the present study, 53 fungal endophytes were isolated from the bulbs of Fritillaria unibracteata var. wabuensis (FUW). Of these, 49 strains were identified and grouped into 17 different taxa, and priority was conferred to the Fusarium genus. All fungal fermented filtrates displayed antioxidant activities. The DPPH activity, total antioxidant capacities (ABTS), reduction power (FRAP), total phenolic content (TPC), total flavonoid content (TFC) and total saponin content (TSC) were evaluated using petroleum ether, ethyl acetate, n-butyl alcohol and ethanol fractions extracted from five representative fungal cultures...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28150271/morphometric-analysis-of-the-lumbar-vertebrae-in-the-turkish-population-using-three-dimensional-computed-tomography-correlation-with-sex-age-and-height
#8
Ali Güleç, Burkay Kutluhan Kaçıra, Harun Kütahya, Hüseyin Özbiner, Mehmet Öztürk, Çiğdem Samur Solbaş, İbrahim Erdem Gökmen
BACKGROUND: Morphometric measurements of lumbar vertebrae are different in European and Asian populations. Transpedicular screws are candidates for the ideal method to treat instability of lumbar vertebrae and provide very strong stabilization. Our study reflects the variation of morphometric measurements of lumbar vertebrae in the Turkish population according to sex, age, and height PURPOSE: The aim of our study was to measure the transverse pedicle diameter (TPD), vertical pedicle diameter (VPD), pedicle axis length (PAL), and transverse pedicle angle (TPA) of the lumbar vertebrae using 3D-CT and assess variations according to sex, age, and height...
February 2, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28123856/microrna-363-3p-inhibits-papillary-thyroid-carcinoma-progression-by-targeting-pik3ca
#9
Jia Liu, Qun Li, Rui Li, Peiyou Ren, Su Dong
MicroRNA-363-3p (miR-363-3p) reportedly plays crucial roles in tumor development and progression in many types of cancers. However, its role in papillary thyroid carcinoma (PTC) remain largely unclear. We therefore investigated the function and underlying mechanism of miR-363-3p in PTC. Here, we found that miR-363-3p was significantly downregulated in human PTC tissue samples and cell lines, and that miR-363-3p levels are negatively correlated with advanced clinical stage and lymph node metastasis. In addition to suppressing tumor growth in vivo, restoration of miR-363-3p in TPC-1 cells significantly inhibits proliferation, migration, and invasion and induced apoptosis in vitro...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28118858/effect-of-climate-change-on-phytochemical-diversity-total-phenolic-content-and-in-vitro-antioxidant-activity-of-aloe-vera-l-%C3%A2-burm-f
#10
Sandeep Kumar, Amita Yadav, Manila Yadav, Jaya Parkash Yadav
BACKGROUND: The aim of the present study was to analyse the effect of climate change on phytochemicals, total phenolic content (TPC) and antioxidant potential of methanolic extracts of Aloe vera collected from different climatic zones of the India. METHODS: Crude methanolic extracts of A. vera from the different states of India were screened for presence of various phytochemicals, total phenolic content and in vitro antioxidant activity. Total phenolic content was tested by Folin-Ciocalteau reagent based assay whilst DPPH free radical scavenging assay, metal chelating assay, hydrogen peroxide scavenging assay, reducing power assay and β carotene-linoleic assay were used to assess the antioxidant potential of A...
January 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28115768/wheat-water-chestnut-flour-blends-effect-of-baking-on-antioxidant-properties-of-cookies
#11
Musarat Shafi, Waqas N Baba, Farooq Ahmad Masoodi, Rafiya Bazaz
Proximate composition, mineral content, functional, pasting and antioxidant properties of water chestnut flour (WCF) were compared with refined wheat flour. WCF showed higher phenolic (4.25 gGAE/1000 g), flavonoid (1.92 g QE/1000 g) and mineral content (K, Mg, Zn, Cu) than wheat flour. WCF showed greater retrogradation tendency but lower peak viscosity than wheat flour. Wheat flour - WCF blends and cookies were evaluated for water activity, physical & textural properties. Water activity of cookies decreased significantly (0...
December 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28115754/amino-acids-profile-and-antioxidant-activity-of-different-lupinus-angustifolius-seeds-after-solid-state-and-submerged-fermentations
#12
Vytaute Starkute, Elena Bartkiene, Vadims Bartkevics, Janis Rusko, Daiva Zadeike, Grazina Juodeikiene
The objective of this study was to investigate the amino acids profile, total phenolic compounds (TPC) content, antioxidant activity after submerged (SmF) and solid state (SSF) fermentations of different Lupinus angustifolius seeds by the Lactobacillus sakei KTU05-6. Additionally, the impact of different lupin seeds as fermentation media for LAB biomass and d/l-lactic acid production was analysed. The d/l ratio for SmF and SSF treated lupin samples varied from 0.15 to 0.45 and from 0.12 to 0.46, 16 respectively...
December 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28115751/phenolics-extraction-from-sweet-potato-peels-modelling-and-optimization-by-response-surface-modelling-and-artificial-neural-network
#13
Ana Anastácio, Rúben Silva, Isabel S Carvalho
Sweet potato peels (SPP) are a major waste generated during root processing and currently have little commercial value. Phenolics with free radical scavenging activity from SPP may represent a possible added-value product for the food industry. The aqueous extraction of phenolics from SPP was studied using a Central Composite Design with solvent to solid ratio (30-60 mL g(-1)), time (30-90 min) and temperature (25-75 °C) as independent variables. The comparison of response surface methodology (RSM) and artificial neural network (ANN) analysis on extraction modelling and optimising was performed...
December 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28114838/antioxidative-activities-and-phenolic-compounds-of-pumpkin-cucurbita-pepo-seeds-and-amaranth-amaranthus-caudatus-grain-extracts
#14
Pier Giorgio Peiretti, Giorgia Meineri, Francesco Gai, Erica Longato, Ryszard Amarowicz
Phenolic compounds were extracted from pumpkin (Cucurbita pepo) seed and amaranth (Amaranthus caudatus) grain into 80% (v/v) methanol. The extracts obtained were characterised by the contents of total phenolic compounds (TPC), trolox equivalent antioxidant capacity (TEAC), ferric-reducing antioxidant power (FRAP) and antiradical activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH(·)) radical. The content of individual phenolic compounds was determined by HPLC-DAD method. Pumpkin seeds showed the higher content of TPC than that from amaranth...
January 23, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28111769/suitability-of-combination-of-calcium-propionate-and-chitosan-for-preserving-minimally-processed-banana-quality
#15
Amin Mirshekari, Babak Madani, John B Golding
BACKGROUND: Marketability of fresh-cut banana slices is limited by the rapid rate of fruit softening and browning. However there is no scientific literature on the role of postharvest calcium propionate and chitosan treatment on quality attributes of fresh cut banana and therefore the aim of this research was to investigate these effects. RESULTS: This study showed that the application of calcium propionate plus chitosan (CaP+Chit) treatment retained higher firmness, ascorbic acid content (AA) content, total antioxidant activity (TAA) and total phenolic compounds (TPC) with lower browning, polyphenol oxidase (PPO), peroxidase (POD), polygalacturonase (PG) and pectin methyl esterase (PME) activities and microbial growth compared with the control banana slices after five days of cold storage...
January 23, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28111736/prevalence-of-fibromyalgia-in-turkish-geriatric-population-and-its-impact-on-quality-of-life
#16
Yeşim Garip, Dilek Öztaş, Tuba Güler
OBJECTIVES: The aim of the present study was to examine the presence of fibromyalgia (FM) in elderly adults and to evaluate the impact of the severity of FM on quality of life. METHODS: A total of 100 patients between 65 and 80 years of age were included. The main admission diagnosis of the patients was recorded. Presence of FM was evaluated based on 1990 American College of Rheumatology (ACR) diagnostic criteria. The FM group was comprised of 31 patients fulfilling these criteria, and the remaining 69 patients composed the non-FM group...
October 2016: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28108508/two-pore-channel-function-is-crucial-for-migration-of-invasive-cancer-cells
#17
Ong Nam Phuong Nguyen, Christian Grimm, Lina S Schneider, Yu-Kai Chao, Carina Atzberger, Karin Bartel, Anna Watermann, Melanie Ulrich, Doris Mayr, Christian Wahl-Schott, Martin Biel, Angelika M Vollmar
Metastatic invasion is the major cause of cancer-related deaths. In this study, we introduce two-pore channels (TPC), a recently described class of NAADP- and PI(3,5)P2-sensitive Ca2+-permeable cation channels in the endolysosomal system of cells, as candidate targets for the treatment of invasive cancers. Inhibition of the channel abrogated migration of metastatic cancer cells in vitro. Silencing or pharmacological inhibition of the two-pore channel TPC2 reduced lung metastasis of mammary mouse cancer cells...
January 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#18
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28098872/trim29-promotes-progression-of-thyroid-carcinoma-via-activating-p13k-akt-signaling-pathway
#19
Jinkai Xu, Zongyu Li, Qinghua Su, Jun Zhao, Jiancang Ma
Thyroid cancer (TC) is a common malignancy of the endocrine system. Abnormal expression of tripartite motif-containing 29 (TRIM29) has been reported to promote tumorigenesis and predict poor prognosis in several human malignancies. The aim of this study was to assess the involvement of TRIM29 in the significance and prognosis of TC. Fifty-six tumor samples and their clinicopathological para-meters were obtained from TC patients; the expression level of TRIM29 was detected by RT-qPCR and western blotting. TRIM29 expression was knocked down by small interfering RNA (siRNA) among TT, TPC-1, and K1 cells to investigate the biological role of TRIM29 in TC cells...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28096396/tuning-the-ion-selectivity-of-two-pore-channels
#20
Jiangtao Guo, Weizhong Zeng, Youxing Jiang
Organellar two-pore channels (TPCs) contain two copies of a Shaker-like six-transmembrane (6-TM) domain in each subunit and are ubiquitously expressed in plants and animals. Interestingly, plant and animal TPCs share high sequence similarity in the filter region, yet exhibit drastically different ion selectivity. Plant TPC1 functions as a nonselective cation channel on the vacuole membrane, whereas mammalian TPC channels have been shown to be endo/lysosomal Na(+)-selective or Ca(2+)-release channels. In this study, we performed systematic characterization of the ion selectivity of TPC1 from Arabidopsis thaliana (AtTPC1) and compared its selectivity with the selectivity of human TPC2 (HsTPC2)...
January 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
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