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https://www.readbyqxmd.com/read/29235838/hydrogel-with-ultra-fast-self-healing-property-both-in-air-and-underwater
#1
Weipeng Chen, Dezhao Hao, Wanjun Hao, Xinglin Guo, Lei Jiang
Self-healing hydrogels have a great potential utilization in 3D printing, soft robotics, and tissue engineering, due to the ability to expand the useful lifespan. There has been a large number of successful strategies in developing hydrogels which exhibit rapid and autonomous recovery. However, a gel with an excellent self-healing performance within several seconds is still an enormous challenge. Here, an ultra-fast self-healing hydrogel based on a PVA/agarose double network is presented. The gel utilizing dynamic borate bond exhibits 100% cure in strength and elongation after healing for 10 seconds in air, and this hydrogel shows an excellent self-healing property underwater as well...
December 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29235208/optical-coherence-tomography-for-assessment-of-epithelialization-in-a-human-ex-vivo-wound-model
#2
George D Glinos, Sebastian H Verne, Adam S Aldahan, Liang Liang, Keyvan Nouri, Sharon Elliot, Marilyn Glassberg, Delia Cabrera DeBuc, Tulay Koru-Sengul, Marjana Tomic-Canic, Irena Pastar
The ex vivo human skin wound model is a widely accepted model to study wound epithelialization. Due to a lack of animal models that fully replicate human conditions, the ex vivo model is a valuable tool to study mechanisms of wound re-epithelialization, as well as for pre-clinical testing of novel therapeutics. The current standard for assessment of wound healing in this model is histomorphometric analysis, which is labor intensive, time consuming, and requires multiple biological and technical replicates in addition to assessment of different time points...
December 13, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29235158/single-staged-implant-placement-using-bone-ring-technique-with-and-without-membrane-placement-an-experimental-study-in-the-beagle-dog
#3
Maiko Haga-Tsujimura, Ken Nakahara, Eizaburo Kobayashi, Kensuke Igarashi, Benoit Schaller, Nikola Saulacic
AIM: To evaluate the impact of a collagen membrane on bone remodeling and osseointegration of implants placed simultaneously with a bone ring technique. MATERIAL AND METHODS: Standardized, vertical alveolar bone defects in the mandibles of six dogs were created. Tapered dental implants designed for two-stage subcrestal placement were inserted simultaneously with a bone ring technique. On one side of the mandible, the augmented sites were covered with a collagenous membrane...
December 12, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29234747/flapless-vs-flapped-implant-insertion-in-patients-with-controlled-type-2-diabetes-subjected-to-delayed-loading-1-year-follow-up-results-from-a-randomised-controlled-trial
#4
Kaushal Kishor Agrawal, Jitendra Rao, Mohd Anwar, Kalpana Singh, D Himanshu
PURPOSE: To compare the outcome of dental implants placed following full-thickness flap surgery with flapless surgery in controlled type 2 diabetic patients. MATERIALS AND METHODS: A total of 92 controlled type 2 diabetic patients, who needed missing mandibular first molars to be replaced by implants, were selected for a single-centre, parallel group, double-blinded randomised controlled trial. Patients were randomly allocated into two groups: flap (46 patients) vs flapless (46 patients) implant placement...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234654/reconstruction-of-soft-tissue-lesions-of-the-foot-with-the-use-of-the-medial-plantar-flap
#5
Jefferson Lessa Soares de Macedo, Simone Corrêa Rosa, Altino Vieira de Rezende Filho Neto, Adilson Alves da Silva, Alex Corcino Silva de Amorim
Objective: To study use of the medial plantar flap for reconstruction of the heel and foot. Method: The authors share their clinical experience with the use of the medial plantar artery flap for coverage of tissue defects around the foot and heel after trauma. Twelve cases of medial plantar artery flap performed from January 2001 to December 2013 were included. Results: Of the 12 patients, ten were male and two were female. The indications were traumatic loss of the heel pad in ten cases and the dorsal foot in two cases...
November 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/29234410/scorpion-venom-active-polypeptide-may-be-a-new-external-drug-of-diabetic-ulcer
#6
Ting Wan, Luocheng Li, Zhanyong Zhu, Siyang Liu, Yueqiang Zhao, Mosheng Yu
Background: The epidermal growth factor (EGF) is recognized medicine of therapy in ulcer. However, its efficacy has been challenged. We compared scorpion venom active polypeptide and EGF of therapeutic effects in diabetic ulcer. Methods: The scorpion venom active polypeptide is made into gel. Fourteen diabetic SD rats were randomly divided into scorpion peptide gel group (SPG group) and EGF group. Before treatment, the rat model of diabetic ulcer was created. The levels of IL-1, IL-6, IL-8, and TNF-α in the wound tissue were measured at different time points during the treatment, secretions of wound were collected for bacterial culture, and the wound healing was recorded...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234120/oral-epithelial-cell-sheets-engraftment-for-esophageal-strictures-after-endoscopic-submucosal-dissection-of-squamous-cell-carcinoma-and-airplane-transportation
#7
Naoyuki Yamaguchi, Hajime Isomoto, Shinichiro Kobayashi, Nobuo Kanai, Kengo Kanetaka, Yusuke Sakai, Yoshiyuki Kasai, Ryo Takagi, Takeshi Ohki, Hiroko Fukuda, Tsutomu Kanda, Kazuhiro Nagai, Izumi Asahina, Kazuhiko Nakao, Masayuki Yamato, Teruo Okano, Susumu Eguchi
Endoscopic submucosal dissection (ESD) permits en bloc removal of superficial oesophageal squamous cell carcinoma (ESCC). However, post-procedure stricture is common after ESD for widespread tumours, and multiple endoscopic balloon dilation (EBD) procedures are required. We aimed to evaluate the safety and effectiveness of endoscopic transplantation of tissue-engineered autologous oral mucosal epithelial cell sheets that had been transported by air over a distance of 1200 km in controlling postprocedural oesophageal stricture...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233701/in%C3%A2-vivo-effects-of-geranylgeraniol-on-the-development-of-bisphosphonate-related-osteonecrosis-of-the-jaws
#8
Filip Koneski, Danica Popovic-Monevska, Icko Gjorgoski, Jovanka Krajoska, Mirjana Popovska, Ilijana Muratovska, Boris Velickovski, Gordana Petrushevska, Vladimir Popovski
BACKGROUND: Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a complication of the bisphosphonate (BP) treatment and its pathopysiology is still not fully understood. The existing preventive and treatment options require updates and more attention. Geranylgeraniol (GGOH) so far demonstrated an increased activity and viability of the cells previously treated with zoledronic acid (ZA). The aim of this study was to evaluate the in vivo effects of GGOH on the development of BRONJ...
November 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233656/the-atypical-protein-kinase-riok3-contributes-to-glioma-cell-proliferation-survival-migration-invasion-and-the-akt-mtor-signaling-pathway
#9
Tong Zhang, Daofei Ji, Peng Wang, Liang Dong, Lei Jin, Hengliang Shi, Xuejiao Liu, Qingming Meng, Rutong Yu, Shangfeng Gao
The RIO (right open reading frame) protein kinases include RIOK1, RIOK2 and RIOK3. Emerging evidence has suggested an important role of RIO kinases in cancer cell proliferation, apoptosis, migration and invasion. However, the expression profile and specific roles of RIOK3 are largely unknown during glioma progression. In the current study, quantitative real-time PCR, Western blot, and immunohistochemical analysis showed that RIOK3 was upregulated in glioma tissues. Available database analysis revealed that higher levels of RIOK3 were associated with poorer survival outcome in glioma patients...
December 9, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29232436/cellular-versus-acellular-grafts-for-diabetic-foot-ulcers-altering-the-protocol-to-improve-recruitment-to-a-comparative-efficacy-trial
#10
Catherine N Tchanque-Fossuo, Sara E Dahle, Hadar Lev-Tov, Chin-Shang Li, R Rivkah Isseroff
Diabetic foot ulcers (DFUs) have a substantial impact on public health. The standard of care (SOC) for DFUs consists of a multidisciplinary approach involving glycemic control, wound care with debridement of necrotic tissue, application of a moist dressing, infection control, use of off-loading devices, and patient education. New therapeutic devices aim to target the extracellular matrix (ECM) that is impaired in DFU; however, there is insufficient data on the effectiveness of such therapies along with lack of evidence on their long-term effectiveness...
November 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29232032/erosive-pustular-dermatosis-of-the-scalp-reappraisal-of-an-underrecognized-entity
#11
REVIEW
Michael Wilk, Bettina G Zelger, Undine Hauser, Reinhard Höpfl, Bernhard Zelger
Erosive pustular dermatosis of the scalp (EPDS) is an inflammatory dermatosis of unknown etiology. Herein, we present a review of the disease and report our own clinical and histopathological experience in eleven patients. EPDS tends to spontaneously affect bald areas of the scalp in elderly individuals. A history of previous surgery at the same site - as observed in four of our patients - is common. Coronary artery disease, cerebrovascular insult, arterial hypertension, diabetes mellitus, and severe cases of cancer were frequent comorbidities...
December 12, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/29231990/tendon-explant-cultures-to-study-the-communication-between-adipose-stem-cells-and-native-tendon-niche
#12
Raquel Costa-Almeida, Dominika Berdecka, Márcia T Rodrigues, Rui L Reis, Manuela E Gomes
Poor clinical outcomes of tendon repair, together with limited regenerative capacity of the tissue, have triggered the search for alternative regenerative medicine strategies. Human adipose-derived stem cells (hASCs) are being investigated as a promising cell source in contributing for tendon repopulation and reconstruction. However, the mechanisms involved in a potential beneficial effect in tendon regeneration are still to be uncovered. To gain further insights on the bi-directional crosstalk occurring between stem cells and the native tendon niche, it was used an indirect (trans-well) system for co-culturing human tendon explants and hASCs...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29231244/sirt7-depletion-inhibits-cell-proliferation-migration-and-increases-drug-sensitivity-by-activating-p38mapk-in-breast-cancer-cells
#13
Kun-Lin Chen, Lian Li, Fang-Xiao Yang, Cheng-Min Li, Yi-Ru Wang, Gen-Lin Wang
SIRT7 is a member of the sirtuin family of proteins that are known to be associated with tumor development. However, the functional roles and molecular mechanisms underlying the function of SIRT7 in breast cancer cell survival and tumor development remain unclear. Recent studies demonstrated that SIRT7 is upregulated in breast cancer cells and tissues. In the present study, we systematically explored the roles of SIRT7 in the growth of breast cancer cells and tumors both in vitro and in vivo. Our results showed that SIRT7 plays a major role in facilitating cell survival by promoting cell proliferation and inhibiting apoptosis...
December 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29230909/histatins-wound-healing-and-cell-migration
#14
Pedro Torres, Martín Castro, Montserrat Reyes, Vicente A Torres
Wounds in the oral mucosa heal faster and more efficiently than those in the skin, although the mechanisms underlying these differences are not completely clear. In the last 10 years, a group of salivary peptides, the histatins, have gained attention on behalf of their ability to improve several phases of the wound healing process. In addition to their roles as antimicrobial agents and in enamel maintenance, histatins elicit other biological effects, namely by promoting the migration of different cell types contained in the oral mucosa and in non-oral tissues...
December 12, 2017: Oral Diseases
https://www.readbyqxmd.com/read/29229147/effects-of-dermal-wounding-on-distal-primary-tumor-immunobiology-in-mice
#15
Leah M Pyter, Daniel B McKim, Yasmin Husain, Humberto Calero, Jonathan P Godbout, John F Sheridan, Phillip T Marucha, Christopher G Engeland
BACKGROUND: Before primary oral tumors are treated, various prophylactic procedures that require tissue repair are often necessary (e.g. biopsies, tooth extractions, radiation, and tracheotomies). Wound healing and tumor growth harness similar immune/inflammatory mechanisms. Our previous work indicates that tumors impair wound healing, although the extent to which tissue repair conversely influences tumor growth is poorly understood. Here, we test the hypothesis that dermal wound healing exacerbates primary tumor growth and influences tumor immunobiology...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228710/irisin-treatment-improves-healing-of-dystrophic-skeletal-muscle
#16
Musarrat Maisha Reza, Chu Ming Sim, Nathiya Subramaniyam, Xiaojia Ge, Mridula Sharma, Ravi Kambadur, Craig McFarlane
Background: Irisin is an exercise induced myokine that is shown to promote browning of adipose tissue and hence, increase energy expenditure. Furthermore, our unpublished results indicate that Irisin improves myogenic differentiation and induces skeletal muscle hypertrophy. Since exercise induced skeletal muscle hypertrophy improves muscle strength, we wanted to investigate if ectopic injection of Irisin peptide improves skeletal muscle function in a mouse model of muscular dystrophy...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228420/knockdown-of-long-noncoding-rna-linc-itgb1-suppresses-migration-invasion-of-hepatocellular-carcinoma-via-regulating-zeb1
#17
W-W Yu, K Wang, G-J Liao
OBJECTIVE: This research focuses on the influence of linc-ITGB1 on the metastasis of hepatocellular carcinoma and further explores its underlying mechanism. PATIENTS AND METHODS: A total of 70 hepatocellular carcinoma patients were chosen for our study. RT-qPCR was used for detecting the expression level of linc-ITGB1 in their cancer tissues. Moreover, the expression level of linc-ITGB1 was also detected in hepatocellular carcinoma cell lines. Furthermore, whether linc-ITGB1 could affect the migrated and invaded ability of hepatocellular carcinoma cells was determined by wound healing assay and transwell assay...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29228043/novel-systems-for-the-application-of-isolated-tensile-compressive-and-shearing-stimulation-of-distraction-callus-tissue
#18
Nicholaus Meyers, Julian Schülke, Anita Ignatius, Lutz Claes
BACKGROUND: Distraction osteogenesis is a procedure widely used for the correction of large bone defects. However, a high complication rate persists, likely due to insufficient stability during maturation. Numerical fracture healing models predict bone regeneration under different mechanical conditions allowing fixation stiffness optimization. However, most models apply a linear elastic material law inappropriate for the transient stresses/strains present during limb lengthening or segment transport...
2017: PloS One
https://www.readbyqxmd.com/read/29227581/aging-of-lymphoid-organs-can-photobiomodulation-reverse-age-associated-thymic-involution-via-stimulation-of-extrapineal-melatonin-synthesis-and-bone-marrow-stem-cells
#19
REVIEW
Denis Odinokov, Michael R Hamblin
Thymic atrophy and the subsequent reduction in T cell production are the most noticeable age-related changes affecting lymphoid organs in the immune system. In fact thymic involution has been described as "programmed aging". New therapeutic approaches such as photobiomodulation (PBM) may reduce or reverse these changes. PBM (also known as low-level laser therapy or LLLT) involves the delivery of non-thermal levels of red or near-infrared light that are absorbed by mitochondrial chromophores, in order to prevent tissue death and stimulate healing and regeneration...
December 11, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29227559/magnetic-resonance-measurements-of-tissue-quantity-and-quality-using-t2-relaxometry-predict-temporal-changes-in-the-biomechanical-properties-of-the-healing-acl
#20
Jillian E Beveridge, Jason T Machan, Edward G Walsh, Ata M Kiapour, N Padmini Karamchedu, Kaitlyn E Chin, Benedikt L Proffen, Jakob T Sieker, Martha M Murray, Braden C Fleming
The purpose of this study was to develop a magnetic resonance T2 * relaxometry-based multiple linear regression model to predict the structural properties of the healing anterior cruciate ligament (ACL) over a 24-week healing period following ACL repair in Yucatan minipigs. Two hypotheses were tested: (1) that a regression model based on ACL sub-volumes containing short and long T2 * relaxation times would outperform a competing model based on sub-volumes of short T2 * relaxation times only; and (2) that an optimized regression model would be capable of predicting ACL structural properties between 6 and 24 weeks post-repair...
December 11, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
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