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https://www.readbyqxmd.com/read/28918583/evidence-for-contrasting-accumulation-pattern-of-cadmium-in-relation-to-other-elements-in-senilia-senilis-and-tagelus-adansoni-from-the-bijag%C3%A3-s-archipelago-guinea-bissau
#1
Teresa Catry, Paula Figueira, Lina Carvalho, Rui Monteiro, Pedro Coelho, Pedro Miguel Lourenço, Paulo Catry, Quintino Tchantchalam, Inês Catry, Maria J Botelho, Eduarda Pereira, José Pedro Granadeiro, Carlos Vale
Shellfish harvesting in intertidal areas is a widespread and economically important activity in many countries across West Africa. However, in some areas, there is virtually no information concerning the levels of contaminants (and other elements related to nutritional aspects) in the harvested species. We collected sediments and several individuals of the West African bloody cockle Senilia senilis and of the razor clam Tagelus adansoni during the dry season of 2015 nearby three islands in the Bijagós archipelago, Guinea-Bissau...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918266/nanomedicine-for-safe-healing-of-bone-trauma-opportunities-and-challenges
#2
REVIEW
Shahed Behzadi, Gaurav A Luther, Mitchel B Harris, Omid C Farokhzad, Morteza Mahmoudi
Historically, high-energy extremity injuries resulting in significant soft-tissue trauma and bone loss were often deemed unsalvageable and treated with primary amputation. With improved soft-tissue coverage and nerve repair techniques, these injuries now present new challenges in limb-salvage surgery. High-energy extremity trauma is pre-disposed to delayed or unpredictable bony healing and high rates of infection, depending on the integrity of the soft-tissue envelope. Furthermore, orthopedic trauma surgeons are often faced with the challenge of stabilizing and repairing large bony defects while promoting an optimal environment to prevent infection and aid bony healing...
September 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/28918264/past-matrix-stiffness-primes-epithelial-cells-and-regulates-their-future-collective-migration-through-a-mechanical-memory
#3
Samila Nasrollahi, Christopher Walter, Andrew J Loza, Gregory V Schimizzi, Gregory D Longmore, Amit Pathak
During morphogenesis and cancer metastasis, grouped cells migrate through tissues of dissimilar stiffness. Although the influence of matrix stiffness on cellular mechanosensitivity and motility are well-recognized, it remains unknown whether these matrix-dependent cellular features persist after cells move to a new microenvironment. Here, we interrogate whether priming of epithelial cells by a given matrix stiffness influences their future collective migration on a different matrix - a property we refer to as the 'mechanical memory' of migratory cells...
September 8, 2017: Biomaterials
https://www.readbyqxmd.com/read/28918185/isolated-limb-perfusion-for-locally-advanced-angiosarcoma-in-extremities-a-multi-centre-study
#4
E A Huis In 't Veld, D J Grünhagen, C Verhoef, H G Smith, A C J van Akkooi, R Jones, F van Coevorden, A J Hayes, W J van Houdt
BACKGROUND: Angiosarcomas are rare and aggressive soft-tissue sarcomas. The only potential curative treatment is complete surgical excision. This study reports the outcome of isolated limb perfusion (ILP) with high-dose melphalan and tumour necrosis factor α for locally advanced angiosarcoma. MATERIAL AND METHODS: All patients who underwent an ILP for angiosarcomas between 1991 and 2016 in three tertiary referral centres were identified from prospectively maintained databases...
September 14, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28917983/temperature-dependence-of-speed-of-sound-and-attenuation-of-porcine-left-ventricular-myocardium
#5
Krisztián Füzesi, Natalia Ilyina, Erik Verboven, Koen Van Den Abeele, Miklós Gyöngy, Jan D'hooge
The temperature dependence of soft tissue acoustic properties is relevant for monitoring tissue hyperthermia. In the current work, the propagation speed and attenuation of healthy porcine left ventricular myocardium (N=5) was investigated in a frequency range relevant for clinical diagnostic imaging, i.e. 2.5-13.0MHz. Each tissue sample was held in a water bath at a temperature T=25°C, heated to 45°C, and allowed to cool back down to 25°C. Due to initial tissue swelling, the data for decreasing temperatures was considered more reliable...
September 6, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28917705/long-term-retention-of-ecm-hydrogel-after-implantation-into-a-sub-acute-stroke-cavity-reduces-lesion-volume
#6
Harmanvir Ghuman, Madeline Gerwig, Francesca J Nicholls, Jessie Liu, Julia Donnelly, Stephen F Badylak, Michel Modo
Salvaging or functional replacement of damaged tissue caused by stroke in the brain remains a major therapeutic challenge. In situ gelation and retention of a hydrogel bioscaffold composed of 8 mg/mL extracellular matrix (ECM) can induce a robust invasion of cells within 24 hours and potentially promote a structural remodeling to replace lost tissue. Herein, we demonstrate a long-term retention of ECM hydrogel within the lesion cavity. A decrease of approximately 32% of ECM volume is observed over 12 weeks...
September 13, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28917626/ultrasound-assisted-liposuction-provides-a-source-for-functional-adipose-derived-stromal-cells
#7
Dominik Duscher, Zeshaan N Maan, Anna Luan, Matthias M Aitzetmüller, Elizabeth A Brett, David Atashroo, Alexander J Whittam, Michael S Hu, Graham G Walmsley, Khosrow S Houschyar, Arndt F Schilling, Hans-Guenther Machens, Geoffrey C Gurtner, Michael T Longaker, Derrick C Wan
BACKGROUND AIMS: Regenerative medicine employs human mesenchymal stromal cells (MSCs) for their multi-lineage plasticity and their pro-regenerative cytokine secretome. Adipose-derived mesenchymal stromal cells (ASCs) are concentrated in fat tissue, and the ease of harvest via liposuction makes them a particularly interesting cell source. However, there are various liposuction methods, and few have been assessed regarding their impact on ASC functionality. Here we study the impact of the two most popular ultrasound-assisted liposuction (UAL) devices currently in clinical use, VASER (Solta Medical) and Lysonix 3000 (Mentor) on ASCs...
September 13, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28917520/short-term-complications-in-intra-and-extra-articular-anterior-cruciate-ligament-reconstruction-comparison-with-the-literature-on-isolated-intra-articular-reconstruction-a-multicenter-study-by-the-french-society-of-arthroscopy
#8
J C Panisset, R Pailhé, B Schlaterrer, L Sigwalt, B Sonnery-Cottet, C Lutz, S Lustig, C Batailler, S Bertiaux, F P Ehkirch, P Colombet, C Steltzlen, M L Louis, P D'ingrado, F Dalmay, P Imbert, D Saragaglia
INTRODUCTION: Lateral tenodesis (LT) is performed to limit the risk of iterative tear following anterior cruciate ligament (ACL) reconstruction in at-risk patients. By adding an extra procedure to isolated ACL graft, LT reconstruction increases operating time and may complicate postoperative course. The objective of the present study was to evaluate the rate of early complications. The study hypothesis was that associating ALL reconstruction to ACL reconstruction does not increase the complications rate found with isolated ACL reconstruction...
September 13, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28917436/comparison-of-the-loop-technique-with-incision-and-drainage-for-soft-tissue-abscesses-a-systematic-review-and-meta-analysis
#9
REVIEW
Michael Gottlieb, Gary D Peksa
INTRODUCTION: Skin and soft tissue infections are a common presentation to the emergency department. Traditional management of abscesses involves a linear incision through the center of the abscess with packing placed. The loop drainage technique (LDT) is an alternate approach that may reduce pain and scarring, as well as decrease the number of follow up visits needed. This systematic review and meta-analysis aimed to compare the efficacy of the LDT with conventional incision and drainage (CID) in the treatment of soft tissue abscesses...
September 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28917384/serious-infections-among-a-large-cohort-of-subjects-with-systemically-treated-psoriasis
#10
Allison S Dobry, Charles P Quesenberry, G Thomas Ray, Jamie L Geier, Maryam M Asgari
BACKGROUND: Biologic therapy is effective for treatment of moderate-to-severe psoriasis but may be associated with an increased risk for serious infection. OBJECTIVE: To estimate the serious infection rate among patients with psoriasis treated with biologic as compared with nonbiologic systemic agents within a community-based health care delivery setting. METHODS: We identified 5889 adult Kaiser Permanente Northern California health plan members with psoriasis who had ever been treated with systemic therapies and calculated the incidence rates and 95% confidence intervals (CIs) for serious infections over 29,717 person-years of follow-up...
September 13, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28917265/olaratumab-pdgfr-%C3%AE-inhibition-as-a-novel-tool-in-the-treatment-of-advanced-soft-tissue-sarcomas
#11
REVIEW
Bruno Vincenzi, Giuseppe Badalamenti, Andrea Napolitano, Mariella Spalato Ceruso, Francesco Pantano, Giovanni Grignani, Antonio Russo, Daniele Santini, Massimo Aglietta, Giuseppe Tonini
Advanced soft tissue sarcomas are aggressive cancers with limited therapeutic options. Recently, inhibition of platelet-derived growth factor receptor (PDGFR)-α by the monoclonal antibody olaratumab showed promising clinical activity. If confirmed, this would be one of the first examples of targeted therapy effective in advanced soft tissue sarcomas therapy independently of the histologic subtype. Here, we reviewed the biology of the PDGF/PDGFR axis, particularly focusing on its role in cancer, and then we discussed on the effects of PDGFR-α inhibition in the therapy of advanced soft tissue sarcomas...
October 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28916745/cadmium-effects-on-dna-and-protein-metabolism-in-oyster-crassostrea-gigas-revealed-by-proteomic-analyses
#12
Jie Meng, Wenxiong Wang, Li Li, Qi Yin, Guofan Zhang
Marine molluscs, including oysters, can concentrate high levels of cadmium (Cd) in their soft tissues, but the molecular mechanisms of Cd toxicity remain speculative. In this study, Pacific oysters (Crassostrea gigas) were exposed to Cd for 9 days and their gills were subjected to proteomic analysis, which were further confirmed with transcriptomic analysis. A total of 4,964 proteins was quantified and 515 differentially expressed proteins were identified in response to Cd exposure. Gene Ontology enrichment analysis revealed that excess Cd affected the DNA and protein metabolism...
September 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28916133/a-modified-deltoid-splitting-approach-with-axillary-nerve-bundle-mobilization-for-proximal-humeral-fracture-fixation
#13
Young Ho Shin, Young Ho Lee, Ho Sung Choi, Min Bom Kim, Sung Hee Pyo, Goo Hyun Baek
INTRODUCTION: The deltopectoral and the deltoid splitting approach are commonly used for the treatment of proximal humeral fractures. While the deltopectoral approach requires massive soft tissue devascularization, the deltoid splitting approach needs an additional skipped incision to avoid axillary nerve injury. The purpose of this study was to describe a modified anterolateral deltoid splitting approach with axillary nerve bundle mobilization in the treatment of proximal humeral fractures and to assess its radiologic and clinical outcomes...
September 8, 2017: Injury
https://www.readbyqxmd.com/read/28915955/implications-of-bisphosphonate-calcium-ion-depletion-interfering-with-desmosome-epithelial-seal-in-osseointegrated-implants-and-pressure-ulcers
#14
Louis Z G Touyz, Kelvin I Afrashtehfar
Osteoporosis (OP) is a global bone disease prevalent in aging in humans, especially in older women. Bisphosphonates (BPs) are commonly used as therapy for OP as it influences hard and soft tissues calcium metabolism. Mucosal and dermal ulceration with exposure of underlying bone arises from incomplete epithelial recovery due to reduced desmosome formation deriving from lack of available calcium. Pathological situations such as bisphosphonate-related osteonecrosis of the jaw have been described. This hypothesis states other situations which demand intact functional desmosomes such as healing skin over chronic pressure points leading to pressure ulcers (as well-known as bedsores, pressure sores, pressure injuries, decubitus ulcers), and hemidesmosomes such as epithelial seals in contact with titanium surfaces will have a higher prevalence of breakdown among patients being treated with BPs...
September 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28915933/mir-1290-contributes-to-colorectal-cancer-cell-proliferation-by-targeting-inpp4b
#15
Qingzhu Ma, Yan Wang, Hualing Zhang, Fengqiang Wang
Colorectal cancer (CRC) is one of the most common oncological conditions s worldwide, to date, MicroRNA 1290 (miRNA) has been demonstrated to regulate its progression. We studied the role of miR-1290 in CRC progression. The gene was upregulated in CRC tissues and cells, its overexpression promoted CRC cell proliferation analyzed by MTT assay, colony formation assay and soft agar growth assay. IN addition, miR-1290 knockdown inhibited CRC cell proliferation. We also found that miR-1290 overexpression reduced p27 level and increased Cyclin D1 level both in mRNA and protein levels, while miR-1290 knockdown increased p27 and reduced Cyclin D1 (confirming miR-1290 promoted CRC cell proliferation)...
September 15, 2017: Oncology Research
https://www.readbyqxmd.com/read/28915847/absence-of-ultrasound-inflammation-in-patients-presenting-with-arthralgia-rules-out-the-development-of-arthritis
#16
Myrthe van der Ven, M van der Veer-Meerkerk, D F Ten Cate, N Rasappu, M R Kok, D Csakvari, J M W Hazes, A H Gerards, J J Luime
BACKGROUND: To decrease the burden of disease of rheumatoid arthritis (RA), patients at risk for RA need to be identified as early as possible, preferably when no clinically apparent synovitis can be detected. Up to now, it has been fairly difficult to identify those patients with arthralgia who develop inflammatory arthritis (IA), but recent studies using ultrasound (US) suggest that earlier detection is possible. We aimed to identify patients with arthralgia developing IA within 1 year using US to detect subclinical synovitis at first consultation...
September 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28915302/prevalence-of-gingivitis-in-a-group-of-35-to-70-year-olds-residing-in-puerto-rico
#17
Augusto R Elías-Boneta, Angeliz Encarnación, Sona Rivas-Tumanyan, Beatriz C Berríos-Ouslán, Bayardo García-Godoy, Margarita Murillo, Jomar Diaz-Nicolas, Ferdinand Lugo, Milagros J Toro
OBJECTIVE: Gingivitis, an inflammation of the gingival tissues, typically progresses to periodontitis. The objective of this study is to estimate the prevalence of gingivitis in 35- to 70-year-olds residing in San Juan, Puerto Rico, and assess the differences in gingivitis distribution between age and gender groups. METHODS: A cross-sectional epidemiological study was conducted with a sample of patients from a private practice and patients/employees of the Puerto Rico Medical Center...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28915281/precision-in-dermal-filling-a-comparison-between-needle-and-cannula-when-using-soft-tissue-fillers
#18
Tatjana Pavicic, Konstantin Frank, Katharina Erlbacher, Romy Neuner, Stefan Targosinski, Thilo Schenck, Robert H Gotkin, Sebastian Cotofana
BACKGROUND: Precise implantation of soft tissue fillers to treat the signs of aging is crucial for patient safety and the best aesthetic outcome. Injections are performed commonly with either needles or cannulas, but quantitative comparative data on precise implantation are still elusive. METHODS: Ten fresh-frozen cephalic foreheads (9 male, 1 female) were injected with radiopaque material using both needles and cannulas. Needle injection relied on a perpendicular transcutaneous approach, whereas cannulas were moved in the supra-periosteal plane until reaching the same location as the needle...
September 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28915265/the-accessory-parotid-gland-and-facial-process-of-the-parotid-gland-on-computed-tomography
#19
Dongbin Ahn, Chang Ki Yeo, Soon Yong Han, Jeong Kyu Kim
The purpose of this study was to determine the incidence of an anterior extension of the parotid gland, such as an accessory parotid gland (APG) or facial process (FP) and to evaluate its characteristics on computed tomography (CT) scans. We reviewed CT scans of 1,600 parotid glands from 800 patients. An APG on CT was defined as a soft-tissue mass of the same density as the main parotid gland, located at the anterior part of the main parotid gland, and completely separate from the main parotid gland. An FP was defined as a lobe of the parotid gland protruding anteriorly over the anterior edge of the ramus of the mandible on CT and showing continuity with the main gland...
2017: PloS One
https://www.readbyqxmd.com/read/28914981/fna-cytology-of-solitary-fibrous-tumors-and-the-diagnostic-value-of-stat6-immunocytochemistry
#20
Edneia Tani, Johan Wejde, Kristina Åström, Inga-Lill Wingmo, Olle Larsson, Felix Haglund
BACKGROUND: Solitary fibrous tumors (SFTs) are rare mesenchymal tumors commonly located in the pleura, soft tissues, or meninges and are characterized by the NGFI-A-binding protein 2 (NAB2)-signal transducer and activator of transcription 6 (STAT6) fusion gene. Recent studies have indicated that nuclear STAT6 immunohistochemistry is a specific marker for SFTs. METHODS: The authors reviewed fine-needle aspiration (FNA) specimens from extracranial SFTs diagnosed at their institution between 1993 and 2017...
September 15, 2017: Cancer
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