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https://www.readbyqxmd.com/read/29913529/a-pilot-study-evaluating-cerebral-vasculitis-in-kawasaki-s-disease
#1
Jung Sook Yeom, Young Hye Cho, Chung Mo Koo, Jin Su Jun, Ji Sook Park, Eun Sil Park, Ji-Hyun Seo, Jae-Young Lim, Hyang-Ok Woo, Hee-Shang Youn
Cerebral vasculitis is thought to be a possible underlying mechanism of severe neurological complications of Kawasaki's disease (KD), such as cerebral infarct or aneurysm rupture. To evaluate the intracranial inflammatory response in patients with acute-stage KD, we measured the levels of cytokines (interleukin [IL]-6 and tumor necrosis factor [TNF]-α) and pentraxin-3 (PTX3) in the cerebrospinal fluid of patients with KD ( n  = 7) and compared the levels to those of the age- and sex-matched febrile control patients (bacterial meningitis [ n  = 5], enteroviral meningitis [ n  = 10], nonspecific viral illness without central nervous system involvement [ n  = 10])...
June 18, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29912875/accuracy-of-dengue-clinical-diagnosis-with-and-without-ns1-antigen-rapid-test-comparison-between-human-and-bayesian-network-model-decision
#2
Chaitawat Sa-Ngamuang, Peter Haddawy, Viravarn Luvira, Watcharapong Piyaphanee, Sopon Iamsirithaworn, Saranath Lawpoolsri
Differentiating dengue patients from other acute febrile illness patients is a great challenge among physicians. Several dengue diagnosis methods are recommended by WHO. The application of specific laboratory tests is still limited due to high cost, lack of equipment, and uncertain validity. Therefore, clinical diagnosis remains a common practice especially in resource limited settings. Bayesian networks have been shown to be a useful tool for diagnostic decision support. This study aimed to construct Bayesian network models using basic demographic, clinical, and laboratory profiles of acute febrile illness patients to diagnose dengue...
June 18, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29912713/molecular-epidemiology-of-human-adenovirus-associated-febrile-respiratory-illness-in-soldiers-south-korea-1
#3
Jung Yeon Heo, Ji Yun Noh, Hye Won Jeong, Kang-Won Choe, Joon Young Song, Woo Joo Kim, Hee Jin Cheong
During January 2013-April 2014, we subjected nasopharyngeal specimens collected from patients with acute febrile respiratory illness in a military hospital to PCR testing to detect 12 respiratory viruses and sequence a partial hexon gene for human adenovirus (HAdV) molecular typing. We analyzed the epidemiologic characteristics of HAdV infections and compared clinical characteristics of HAdV types. Among the 305 patients with acute febrile respiratory illness, we detected respiratory viruses in 139 (45.6%) patients; HAdV was the most prevalent virus (69 cases)...
July 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29912676/evaluation-of-team-dynamics-before-and-after-remote-simulation-training-utilizing-certain-platform
#4
Kelly M Pennington, Yue Dong, Hongchuan H Coville, Bo Wang, Ognjen Gajic, Diana J Kelm
OBJECTIVE: The current study examines the feasibility and potential effects of long distance, remote simulation training on team dynamics. DESIGN: The study design was a prospective study evaluating team dynamics before and after remote simulation. SUBJECTS: Study subjects consisted of interdisciplinary teams (attending physicians, physicians in training, advanced care practitioners, and/or nurses). SETTING: The study was conducted at nine training sites in eight countries...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29912095/combined-biomarkers-predict-acute-mortality-among-critically-ill-patients-with-suspected-sepsis
#5
Brendan J Kelly, Ebbing Lautenbach, Irving Nachamkin, Susan E Coffin, Jeffrey S Gerber, Barry D Fuchs, Charles Garrigan, Xiaoyan Han, Warren B Bilker, Jacqueleen Wise, Pam Tolomeo, Jennifer H Han
OBJECTIVES: Sepsis is associated with high early and total in-hospital mortality. Despite recent revisions in the diagnostic criteria for sepsis that sought to improve predictive validity for mortality, it remains difficult to identify patients at greatest risk of death. We compared the utility of nine biomarkers to predict mortality in subjects with clinically suspected bacterial sepsis. DESIGN: Cohort study. SETTING: The medical and surgical ICUs at an academic medical center...
July 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29911033/association-between-glycemic-gap-and-adverse-outcomes-in-critically-ill-patients-with-diabetes
#6
Sandeep Donagaon, Mala Dharmalingam
Objectives: Glycemic excursions are commonly seen in patients admitted to the Intensive Care Unit (ICU) and are related to adverse outcomes. Glycemic gap is a marker of this excursion in patients with diabetes. It can be used to predict adverse outcomes in patients with diabetes admitted to the ICU. It is calculated by subtracting A1C-derived average glucose (ADAG) = ([28.7 × HbA1c]-46.7) from plasma glucose at admission. Objective of this study was to correlate glycemic gap and adverse outcomes in patients with type 2 diabetes mellitus (DM) admitted to the ICU...
March 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29910040/sodium-bicarbonate-therapy-for-patients-with-severe-metabolic-acidaemia-in-the-intensive-care-unit-bicar-icu-a-multicentre-open-label-randomised-controlled-phase-3-trial
#7
Samir Jaber, Catherine Paugam, Emmanuel Futier, Jean-Yves Lefrant, Sigismond Lasocki, Thomas Lescot, Julien Pottecher, Alexandre Demoule, Martine Ferrandière, Karim Asehnoune, Jean Dellamonica, Lionel Velly, Paër-Sélim Abback, Audrey de Jong, Vincent Brunot, Fouad Belafia, Antoine Roquilly, Gérald Chanques, Laurent Muller, Jean-Michel Constantin, Helena Bertet, Kada Klouche, Nicolas Molinari, Boris Jung
BACKGROUND: Acute acidaemia is frequently observed during critical illness. Sodium bicarbonate infusion for the treatment of severe metabolic acidaemia is a possible treatment option but remains controversial, as no studies to date have examined its effect on clinical outcomes. Therefore, we aimed to evaluate whether sodium bicarbonate infusion would improve these outcomes in critically ill patients. METHODS: We did a multicentre, open-label, randomised controlled, phase 3 trial...
June 14, 2018: Lancet
https://www.readbyqxmd.com/read/29910027/nutritional-status-affects-cortical-folding-lessons-learned-from-anorexia-nervosa
#8
Fabio Bernardoni, Joseph A King, Daniel Geisler, Julian Birkenstock, Friederike I Tam, Kerstin Weidner, Veit Roessner, Tonya White, Stefan Ehrlich
BACKGROUND: Cortical folding is thought to remain relatively invariant after birth. Therefore, differences seen in psychiatric disorders have been proposed as early biomarkers or used as intermediate phenotypes in imaging genetics studies. Anorexia nervosa (AN) is associated with drastic and rapid structural brain alterations and thus may be an ideal model disorder to study environmental influences on cortical folding. METHODS: To date, the only two studies in AN applied different methods (local gyrification index and mean curvature) and found seemingly discordant results...
May 23, 2018: Biological Psychiatry
https://www.readbyqxmd.com/read/29909763/-pharmacotherapy-of-schizophrenia-spectrum-disorders-state-of-the-art
#9
Philipp E Eich, Beat Nick
Pharmacotherapy of schizophrenia spectrum disorders: State of the Art Abstract. Schizophrenia is a disorder, whose cause and course are still a puzzle. Nevertheless its treatment has made big progresses during the last decades. Early recognition and early treatment of the disorder are very important for a good outcome. Any of the four stages of the illness needs its own treatment concept. Today the gold standard during a acute / progressive psychotic phase is primarily the prescription of an 2nd generation antipsychotic (atypicals)...
June 2018: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/29908681/the-impact-of-early-enteral-nutrition-on-pediatric-acute-respiratory-failure
#10
Amanda Haney, Emily Burritt, Christopher J Babbitt
BACKGROUND AND AIMS: Children who are critically ill undergo metabolic stress and it is important that they receive adequate calories and protein in order to recover. Our objective was to investigate the impact of early enteral nutrition (EEN) on pediatric intensive care (PICU) patients with acute respiratory failure. METHODS: A retrospective cohort study was performed on all patients admitted to a 20 bed PICU at a tertiary children's hospital over a 30 month period...
August 2018: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/29907481/diversity-of-rotavirus-strains-circulating-in-children-under-five-years-of-age-who-presented-with-acute-gastroenteritis-before-and-after-rotavirus-vaccine-introduction-university-teaching-hospital-lusaka-zambia-2008-2015
#11
J C Simwaka, Evans M Mpabalwani, Mapaseka Seheri, Ina Peenze, Mwaka Monze, Belem Matapo, Umesh D Parashar, Jacob Mufunda, Jeffrey M Mphahlele, Jacqueline E Tate, Jason M Mwenda
BACKGROUND: Following the introduction of rotavirus vaccine into the routine immunization schedule, the burden of rotavirus disease has significantly reduced in Zambia. Although rotavirus vaccines appear to confer good cross-protection against both vaccine and non-vaccine strains, concerns about strain replacement following vaccine implementation remain. We describe the diversity of the circulating rotavirus strains before and after the Rotarix® vaccine was introduced in Lusaka from January 2012...
June 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29907141/serum-and-urine-fgf23-and-igfbp-7-for-the-prediction-of-acute-kidney-injury-in-critically-ill-children
#12
Zhenjiang Bai, Fang Fang, Zhong Xu, Chunjiu Lu, Xueqin Wang, Jiao Chen, Jian Pan, Jian Wang, Yanhong Li
BACKGROUND: Fibroblast growth factor 23 (FGF23) and insulin-like growth factor binding protein 7 (IGFBP-7) are suggested to be biomarkers for predicting acute kidney injury (AKI). We compared them with proposed AKI biomarker of cystatin C (CysC), and aimed (1) to examine whether concentrations of these biomarkers vary with age, body weight, illness severity assessed by pediatric risk of mortality III score, and kidney function assessed by estimated glomerular filtration rate (eGFR), (2) to determine the association between these biomarkers and AKI, and (3) to evaluate whether these biomarkers could serve as early independent predictors of AKI in critically ill children...
June 15, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29907105/implementing-cognitive-remediation-and-social-cognitive-interaction-training-into-standard-psychosis-care
#13
Frances Dark, Meredith Harris, Victoria Gore-Jones, Ellie Newman, Harvey Whiteford
BACKGROUND: To evaluate the planned implementation of group based Cognitive Remediation therapy (CR) and Social Cognitive Interaction Training (SCIT) into routine psychosis care in a mental health service in Australia. METHOD: The study was conducted over 3 years in a mental health service in a metropolitan city in Australia. Participants were 22 program facilitators and 128 patients attending the programs. Implementation outcomes were assessed using administrative data, staff surveys and program audits...
June 15, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29906596/are-we-missing-respiratory-viral-infections-in-infants-and-children-comparison-of-a-hospital-based-quality-management-system-with-standard-of-care
#14
Maren Alchikh, Tim Conrad, Christian Hoppe, Xiaolin Ma, Eeva Broberg, Pasi Penttinen, Janine Reiche, Barbara Biere, Brunhilde Schweiger, Barbara Rath
OBJECTIVES: Hospital-based surveillance of influenza and acute respiratory infections relies on ICD-codes and hospital laboratory reports (Standard-of-Care). It is unclear how many cases are missed with either method, i.e. remain undiagnosed/coded as influenza and other respiratory virus infections. Various influenza-like illness (ILI) definitions co-exist with little guidance on how to use them. We are comparing the diagnostic accuracy of standard surveillance methods with a prospective quality management (QM-Program) at a Berlin children's hospital with the Robert-Koch-Institute (RKI)...
June 12, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29906560/erythrocyte-sod1-activity-but-not-sod1-polymorphisms-is-associated-with-icu-mortality-in-patients-with-septic-shock
#15
Nara Aline Costa, Natália Baraldi Cunha, Ana Lucia Gut, Paula Schmidt Azevedo, Bertha Furlan Polegato, Leonardo Antonio Mamede Zornoff, Sergio Alberto Rupp de Paiva, Bruna Zavarize Reis, Ana Angelica Henrique Fernandes, Marcelo Macedo Rogero, Marina Maintinguer Norde, Marcos Ferreira Minicucci
The objective of our study was to evaluate the influence of the superoxide dismutase 1 (SOD1) polymorphisms on erythrocyte SOD1 activity and the mortality of patients with septic shock.We prospectively evaluated 175 patients aged over 18 years with septic shock upon ICU admission. However, 38 patients were excluded. Thus, 137 patients were enrolled in the study. Blood samples were taken within the first 24hours of the patient's admission to determine erythrocyte SOD1 activity and nine SOD1 gene polymorphisms...
June 12, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29904806/virtual-reality-as-a-clinical-tool-for-pain-management
#16
REVIEW
Ali Pourmand, Steven Davis, Alex Marchak, Tess Whiteside, Neal Sikka
PURPOSE OF REVIEW: To evaluate the use of virtual reality (VR) therapies as a clinical tool for the management of acute and chronic pain. RECENT FINDINGS: Recent articles support the hypothesis that VR therapies can effectively distract patients who suffer from chronic pain and from acute pain stimulated in trials. Clinical studies yield promising results in the application of VR therapies to a variety of acute and chronic pain conditions, including fibromyalgia, phantom limb pain, and regional specific pain from past injuries and illnesses...
June 15, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29904444/the-impact-of-nutritional-status-and-complete-blood-count-parameters-on-clinical-outcome-in-geriatric-critically-ill-patients
#17
Abdulkerim Yildiz, Ali Yigit, Ali Ramazan Benli
Background: The geriatric population in intensive care units (ICUs) has recently increased. The aim of this study was to analyse the impact of initial complete blood count (CBC)-related parameters and nutritional status on morbidity and mortality in geriatric ICU patients. Methods: A retrospective analysis was made of geriatric patients admitted to our tertiary adult ICU for 1 year. Patients with a length of stay (LOS) of < 48 h, with hematological malignancy or age < 65 years age were excluded from the study...
July 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29904343/acute-stress-induced-epigenetic-modulations-and-their-potential-protective-role-toward-depression
#18
Francesco Rusconi, Elena Battaglioli
Psychiatric disorders entail maladaptive processes impairing individuals' ability to appropriately interface with environment. Among them, depression is characterized by diverse debilitating symptoms including hopelessness and anhedonia, dramatically impacting the propensity to live a social and active life and seriously affecting working capability. Relevantly, besides genetic predisposition, foremost risk factors are stress-related, such as experiencing chronic psychosocial stress-including bullying, mobbing and abuse-, and undergoing economic crisis or chronic illnesses...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29904286/utility-of-venous-blood-gases-in-severe-sepsis-and-septic-shock
#19
Heath D White, Alfredo Vazquez-Sandoval, Pedro F Quiroga, Juhee Song, Shirley F Jones, Alejandro C Arroliga
Acid-base status is frequently assessed in severe sepsis and septic shock. Venous blood gas sampling is proposed as a less-invasive modality but lacks evidence within this population. The objective of this study was to evaluate the correlation and agreement between arterial blood gas (ABG), peripheral venous blood gas (pVBG), and central venous blood gas (cVBG) in severe sepsis and septic shock. We conducted a prospective, observational cohort study in subjects admitted to the medical intensive care unit. Simultaneous blood gas samples, including ABG, pVBG, and cVBG, were analyzed for correlation and agreement...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29903606/ok-432-pleurodesis-for-the-treatment-of-pneumothorax-in-patients-with-interstitial-pneumonia
#20
Kazumasa Ogawa, Yui Takahashi, Kyoko Murase, Shigeo Hanada, Hironori Uruga, Hisashi Takaya, Atsushi Miyamoto, Nasa Morokawa, Atsuko Kurosaki, Kazuma Kishi
BACKGROUND: Pneumothorax occasionally develops in patients with interstitial pneumonia (IP) and is often intractable. As there exists no well-established treatment for pneumothorax with IP, we evaluated the efficacy and safety of pleurodesis with OK-432, a lyophilized preparation of Streptococcus pyogenes Su strain that has been inactivated by benzylpenicillin. METHODS: We retrospectively evaluated the efficacy and safety of pleurodesis using OK-432 in 39 patients treated for IP-related pneumothorax between January 2006 and May 2017...
June 11, 2018: Respiratory Investigation
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