Gabriel Hundeshagen, Elisabeth Blears, Viktoria Mertin, Andrew G Day, Alen Palackic, Christian Tapking, Valentin Haug, Ulrich Kneser, Björn Bliesener, Adriana C Panayi, Ariel Aballay, Francois Depret, Christian Stoppe, Daren K Heyland
BACKGROUND: Prospective randomized trials in severely burned children have shown the positive effects of oxandrolone (OX), beta blockers (BB) and a combination of the two (BBOX) on hypermetabolism, catabolism and hyperinflammation short- and long-term post-burn. Although data on severely burned adults are lacking in comparison, BB, OX and BBOX appear to be commonly employed in this patient population. In this study, we perform a secondary analysis of an international prospective randomized trial dataset to provide descriptive evidence regarding the current utilization patterns and potential treatment effects of OX, BB and BBOX...
2024: Burns and Trauma