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High resolution manometry

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https://www.readbyqxmd.com/read/29050194/update-on-the-pathophysiology-and-management-of-anorectal-disorders
#1
REVIEW
Tanisa Patcharatrakul, Satish S C Rao
Anorectal disorders are common and present with overlapping symptoms. They include several disorders with both structural and functional dysfunction(s). Because symptoms alone are poor predictors of the underlying pathophysiology, a diagnosis should only be made after evaluating symptoms and physiologic and structural abnormalities. A detailed history, a thorough physical and digital rectal examination and a systematic evaluation with high resolution and/or high definition three-dimensional (3D) anorectal manometry, 3D anal ultrasonography, magnetic resonance defecography and neurophysiology tests are essential to correctly identify these conditions...
October 23, 2017: Gut and Liver
https://www.readbyqxmd.com/read/29043407/changes-in-swallowing-symptoms-and-esophageal-motility-after-thyroid-surgery-a-prospective-cohort-study
#2
Jesper Roed Sorensen, Simone Markoew, Helle Døssing, Laszlo Hegedüs, Steen Joop Bonnema, Christian Godballe
INTRODUCTION: Swallowing difficulties, the pathophysiology behind which is incompletely understood, have been reported in 47-83% of goiter patients referred for thyroidectomy. We aimed at examining the influence of thyroid surgery on swallowing symptoms and esophageal motility. METHODS: Thirty-three patients with benign nodular goiter undergoing thyroid surgery were included. All completed high-resolution esophageal manometry examinations and the goiter symptom scale score, assessed by the thyroid-specific patient-reported outcome measure...
October 11, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/29038193/recurrent-episodes-of-esophageal-candidiasis-without-dysphagia-post-guillain-barr%C3%A3-syndrome-an-unusual-presentation-of-achalasia
#3
Daniel Runggaldier, Michael Fried, Daniel Pohl
Here, we present a case of a 50-year-old male with a history of a Guillain-Barré-syndrome, who was referred to our clinic with recurrent esophageal candidiasis and long-standing intermittent retrosternal cramps for further evaluation. Other symptoms such as dysphagia, regurgitations and weight loss were denied, and prior repeated endoscopy was otherwise unremarkable. Using high resolution impedance manometry, we could demonstrate a panesophageal pressure increase on water swallows and complete aperistalsis of the tubular esophagus, indicating achalasia type II...
October 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29027725/severity-of-ineffective-esophageal-motility-is-associated-with-utilization-of-skeletal-muscle-relaxant-medications
#4
V Rangan, N S George, F Khan, Z Geng, S Gabbard, A Kichler, H Gittleman, R Fass
BACKGROUND: Ineffective esophageal motility (IEM) is the most common finding on high-resolution esophageal manometry (HREM). The underlying mechanisms for IEM remain to be fully elucidated. The aim of this study was to determine if utilization of skeletal muscle relaxants is associated with IEM, and with more severe subtypes of the disorder. METHODS: Patients with diagnosis of IEM were gender and age matched to patients with normal HREM. Demographic information, symptoms, endoscopic findings, medication usage and medical comorbidities were recorded...
October 13, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29024314/clinicomanometric-factors-associated-with-clinically-relevant-esophagogastric-junction-outflow-obstruction-from-the-sandhill-high-resolution-manometry-system
#5
B G Song, Y W Min, H Lee, B-H Min, J H Lee, P-L Rhee, J J Kim
BACKGROUND: Integrated relaxation pressure (IRP) is a key metric for diagnosing esophagogastric junction outflow obstruction (EGJOO). However, its normal value might be different according to the manufacturer of high-resolution manometry (HRM). This study aimed to investigate optimal value of IRP for diagnosing EGJOO in Sandhill HRM and to find clinicomanometric variables to segregate clinically relevant EGJOO. METHODS: We analyzed 262 consecutive subjects who underwent HRM between June 2011 and December 2016 showing elevated median IRP (> 15 mm Hg) but did not satisfy criteria for achalasia...
October 10, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29018480/comparison-of-esophageal-function-tests-in-chinese-patients-with-functional-heartburn-and-reflux-hypersensitivity
#6
Feng Gao, Yan Gao, Xue Chen, Jie Qian, Jie Zhang
OBJECTIVE: To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH). METHODS: Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwent high-resolution manometry and impedance (HRIM), and 24-hour multichannel intraluminal impedance and pH recording (MII/pH) between 2014 and 2016, were enrolled in this study...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28993985/gastroesophageal-reflux-after-sleeve-gastrectomy-a-prospective-mechanistic-study
#7
Muriel Coupaye, Caroline Gorbatchef, Daniela Calabrese, Ouidad Sami, Simon Msika, Benoit Coffin, Séverine Ledoux
BACKGROUND: Evolution of gastroesophageal reflux disease (GERD) after sleeve gastrectomy (SG) is controversial. Some authors report worsening or improvement of preoperative GERD, others the occurrence of de novo GERD between 5 and 69%. AIMS: The aims of this study are to evaluate the evolution of GERD after SG by ambulatory 24-h pH monitoring (APM) and to determine pre- and postoperative clinical and manometric factors associated with its evolution. METHODS: Between 2013 and 2015, 47 patients operated in our center performed APM before and 1 year (14...
October 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28992673/reflux-hypersensitivity-a-new-functional-esophageal-disorder
#8
REVIEW
Takahisa Yamasaki, Ronnie Fass
Reflux hypersensitivity, recently introduced by Rome IV as a new functional esophageal disorder, is currently considered as the presence of typical heartburn symptoms in patients with normal upper endoscopy and esophageal biopsies, normal esophageal pH test and with evidence of a close correlation between patients' heartburn and reflux events. Reflux hypersensitivity is very common and together with functional heartburn accounts for more than 90% of the heartburn patients who failed treatment with proton pump inhibitor twice daily...
October 30, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28988414/upper-esophageal-sphincter-augmentation-reduces-pharyngeal-reflux-in-nasogastric-tube-fed-patients
#9
Hongmei Jiao, Ling Mei, Chenyang Liang, Yun Dai, Zhifang Fu, Lihong Wu, Patrick Sanvanson, Reza Shaker
OBJECTIVES/HYPOTHESIS: Aspiration of gastric refluxate is one of the most commonly observed complications among long-term nasogastric tube (NGT) fed patients. The upper esophageal sphincter (UES) pressure barrier is the main defense mechanism against pharyngeal reflux of gastric contents. Our objective was to investigate the efficacy and safety of the UES assist device (UES-AD) in preventing gastric reflux through the UES in long-term NGT-fed patients. STUDY DESIGN: Self-Controlled Case series...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28987504/aga-institute-high-value-care-statement-is-high-resolution-manometry-always-needed-for-the-diagnosis-of-achalasia
#10
Dustin A Carlson, C Prakash Gyawali
No abstract text is available yet for this article.
October 5, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28976308/a-procedure-for-the-automatic-analysis-of-high-resolution-manometry-data-to-support-the-clinical-diagnosis-of-esophageal-motility-disorders
#11
Alessandro Frigo, Mario Costantini, Chiara Giulia Fontanella, Stefano Merigliano, Emanuele Luigi Carniel
OBJECTIVE: Degenerative phenomena may affect esophageal motility as a relevant social-health problem. The diagnosis of such disorders is usually performed by the analysis of data from high resolution manometry (HRM). Inter- and intra-observer variability frequently affects the diagnosis, with potential interpretative and thus therapeutic errors, with unnecessary or worse treatments. This may be avoided with automatic procedures that minimize human intervention in data processing. METHODS: In order to support the traditional diagnostic process, an automatic procedure was defined considering a specific physio-mechanical model that is able to objectively interpret data from HRM...
October 2, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28953511/therapeutic-outcome-of-achalasia-based-on-high-resolution-manometry-a-korean-multicenter-study
#12
Hyuk Lee, Hyunsoo Chung, Tae Hee Lee, Kyoung Sup Hong, Young Hoon Youn, Jung Ho Park, Hyung Seok Park, Hyojin Park
BACKGROUND: Because achalasia subtype is associated with therapeutic response, it is possible that regional differences in subtype distribution could lead to differences in therapeutic outcomes. STUDY QUESTION: We aimed to evaluate and compare high-resolution manometry (HRM) profiles among the different subtypes of achalasia and to elucidate predictive factors associated with treatment outcomes. STUDY DESIGN: Patients who were diagnosed with achalasia using HRM at 4 Korean university hospitals were retrospectively identified and analyzed...
September 11, 2017: American Journal of Therapeutics
https://www.readbyqxmd.com/read/28951579/expert-consensus-document-advances-in-the-management-of-oesophageal-motility-disorders-in-the-era-of-high-resolution-manometry-a-focus-on-achalasia-syndromes
#13
REVIEW
Peter J Kahrilas, Albert J Bredenoord, Mark Fox, C Prakash Gyawali, Sabine Roman, André J P M Smout, John E Pandolfino
High-resolution manometry (HRM) and new analysis algorithms, summarized in the Chicago Classification, have led to a restructured classification of oesophageal motility disorders. This advance has led to increased detection of clinically relevant disorders, in particular achalasia. It has become apparent that the cardinal feature of achalasia - impaired lower oesophageal sphincter (LES) relaxation - can occur in several disease phenotypes: without peristalsis (type I), with pan-oesophageal pressurization (type II), with premature (spastic) distal oesophageal contractions (type III), or with preserved peristalsis (outlet obstruction)...
September 27, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28948708/variation-in-high-resolution-esophageal-manometry-methodology-in-clinical-practice-results-from-an-international-survey
#14
R Sweis, H Heinrich, M Fox
BACKGROUND: Advances in clinical measurement of esophageal motility and function have improved the assessment of swallowing disorders and reflux symptoms. Variation in data acquisition, analysis, and reporting exists and impacts on diagnosis and management. AIMS AND METHODS: This study examined variation in esophageal manometry methodology between institutions to establish the status in current practice. A structured survey was distributed through international NGM societies using an Internet-based platform...
September 25, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28924729/dor-vs-toupet-fundoplication-after-laparoscopic-heller-myotomy-long-term-randomized-controlled-trial-evaluated-by-high-resolution-manometry
#15
Gonzalo Torres-Villalobos, Enrique Coss-Adame, Janette Furuzawa-Carballeda, Fernanda Romero-Hernández, Blanca Blancas-Breña, Samuel Torres-Landa, Axel Palacios-Ramírez, Edgar Alejandro-Medrano, Axel Hernández-Ávila, Athenea Flores-Najera, Lourdes Margarita Ávila Escobedo, Cecilia Ramírez Angulo, Angélica Rodríguez-Garcés, Miguel Ángel Valdovinos
BACKGROUND: Laparoscopic Heller myotomy (LHM) with partial fundoplication is an effective treatment for achalasia. However, the type of fundoplication is still a subject of debate. AIM: The aim of the study is to identify which partial fundoplication leads to better control of acid exposure, manometric parameters, and symptoms scores. METHODS: A randomized controlled trial was performed to compare Dor vs Toupet fundoplication after LHM. The preoperative diagnosis was made by high-resolution manometry (HRM), upper endoscopy, and barium esophagogram...
September 18, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28922706/functional-outcome-of-low-rectal-resection-evaluated-by-anorectal-manometry
#16
Peter Ihnát, Petr Vávra, Jiří Prokop, Anton Pelikán, Lucia Ihnát Rudinská, Igor Penka
BACKGROUND: Low anterior resection syndrome (LARS) covers disordered bowel function after rectal resection, leading to deterioration in patients' quality of life. The aim of this study was to evaluate anorectal function after laparoscopic low anterior resection (LAR) by means of standardized instruments. METHODS: This was a prospective clinical cohort study conducted in a single institution to assess functional outcome of patients 1 year after laparoscopic LAR by means of LARS score and high-resolution anorectal manometry...
September 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28919276/-focus-on-achalasia
#17
Marie-Anne Guillaumot, Maximilien Barret, Sarah Leblanc, Mahaut Leconte, Bertrand Dousset, Ammar Oudjit, Frédéric Prat, Stanislas Chaussade
The pathophysiology of achalasia is largely unknown, and involves the destruction of ganglion cell in the esophageal myenteric plexus. High-resolution esophageal manometry is the key investigation. Endoscopic pneumodilatation and laparoscopic Heller myotomy have comparable short-term success rates, around 90%. The main complication after pneumodilatation is esophageal perforation, occurring in about 1% of cases. Peroral endoscopic myotomy is a promising treatment modality, however with frequent post-procedural gastroesophageal reflux...
September 14, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28911949/postprandial-high-resolution-impedance-manometry-identifies-mechanisms-of-nonresponse-to-proton-pump-inhibitors
#18
Rena Yadlapati, Michael Tye, Sabine Roman, Peter J Kahrilas, Katherine Ritter, John E Pandolfino
BACKGROUND & AIMS: Recognition of rumination and supragastric belching is often delayed as symptoms may be mistakenly attributed to gastroesophageal reflux disease. However, distinct from gastroesophageal reflux disease, rumination and supragastric belching are more responsive to behavioral interventions than to acid-suppressive and antireflux therapies. Postprandial high-resolution impedance manometry (PP-HRIM) is an efficient method to identify rumination and belches. We investigated the distribution of postprandial profiles determined by PP-HRIM, and identified patient features associated with postprandial profiles among patients with nonresponse to proton pump inhibitors (PPIs)...
September 12, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28884884/a-randomized-double-blind-placebo-controlled-crossover-style-trial-of-buspirone-in-functional-dysphagia-and-ineffective-esophageal-motility
#19
Nitin Aggarwal, Prashanthi Nagavenkata Thota, Rocio Lopez, Scott Gabbard
BACKGROUND: Studies suggest that Ineffective Esophageal Motility (IEM) is the manometric correlate of Functional Dysphagia (FD). Currently, there is no accepted therapy for either condition. Buspirone is a serotonin modulating medication and has been shown to augment esophageal peristaltic amplitude in healthy volunteers. We aimed to determine if buspirone improves manometric parameters and symptoms in patients with overlapping IEM/FD. METHODS: We performed a prospective, double-blind, placebo-controlled, crossover-style trial of 10 patients with IEM/FD...
September 8, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28881900/changes-in-esophageal-motility-after-endoscopic-submucosal-dissection-for-superficial-esophageal-cancer-a-high-resolution-manometry-study
#20
K Takahashi, Y Sato, M Takeuchi, H Sato, N Nakajima, S Ikarashi, K Hayashi, K-I Mizuno, Y Honda, S Hashimoto, J Yokoyama, S Terai
The effect of endoscopic submucosal dissection (ESD) on esophageal motility remains unknown. Therefore, the aim of this study is to elucidate changes in esophageal motility after ESD along with the cause of dysphagia using high-resolution manometry (HRM). This is a before-and-after trial of the effect of ESD on the esophageal motility. Twenty patients who underwent ESD for superficial esophageal carcinoma were enrolled in this study. Patients filled out a questionnaire about dysphagia and underwent HRM before and after ESD...
November 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
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