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https://www.readbyqxmd.com/read/28070841/reproducibility-of-dynamic-contrast-enhanced-mri-and-dynamic-susceptibility-contrast-mri-in-the-study-of-brain-gliomas-a-comparison-of-data-obtained-using-different-commercial-software
#1
Gian Marco Conte, Antonella Castellano, Luisa Altabella, Antonella Iadanza, Marcello Cadioli, Andrea Falini, Nicoletta Anzalone
PURPOSE: Dynamic susceptibility contrast MRI (DSC) and dynamic contrast-enhanced MRI (DCE) are useful tools in the diagnosis and follow-up of brain gliomas; nevertheless, both techniques leave the open issue of data reproducibility. We evaluated the reproducibility of data obtained using two different commercial software for perfusion maps calculation and analysis, as one of the potential sources of variability can be the software itself. METHODS: DSC and DCE analyses from 20 patients with gliomas were tested for both the intrasoftware (as intraobserver and interobserver reproducibility) and the intersoftware reproducibility, as well as the impact of different postprocessing choices [vascular input function (VIF) selection and deconvolution algorithms] on the quantification of perfusion biomarkers plasma volume (Vp), volume transfer constant (K (trans)) and rCBV...
January 9, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28047361/su-f-t-157-physics-considerations-regarding-dosimetric-accuracy-of-analytical-dose-calculations-for-small-field-proton-therapy-a-monte-carlo-study
#2
C Geng, J Daartz, K Cheung, M Bussiere, H Shih, H Paganetti, J Schuemann
PURPOSE: To evaluate the accuracy of dose calculations by analytical dose calculation methods (ADC) for small field proton therapy in a gantry based passive scattering facility. METHODS: 50 patients with intra-cranial disease were evaluated in the study. Treatment plans followed standard prescription and optimization procedures of proton stereotactic radiosurgery. Dose distributions calculated with the Monte Carlo (MC) toolkit TOPAS were used to represent delivered treatments...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047171/we-ab-207b-03-a-computational-methodology-for-determination-of-ctv-to-ptv-margins-with-inter-fractional-shape-variations-based-on-a-statistical-point-distribution-model-for-prostate-cancer-radiation-therapy
#3
Y Shibayama, H Arimura, T Hirose, K Nakamura, T Sasaki, S Ohga, Y Umezu, Y Nakamura, H Honda
PURPOSE: Our assumption was that interfractional shape variations of target volumes could not be negligible for determination of clinical target volume (CTV)-to-planning target volume (PTV) margins. The aim of this study was to investigate this assumption as a simulation study by developing a computational framework of CTV-to-PTV margins with taking the interfractional shape variations into account based on point distribution model (PDM) METHODS: The systematic and random errors for interfractional shape variations and translations of target volumes were evaluated for four types of CTV regions (only a prostate, a prostate plus proximal 1-cm seminal vesicles, a prostate plus proximal 2-cm seminal vesicles, and a prostate plus whole seminal vesicles)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046451/th-cd-209-04-fuzzy-robust-optimization-in-intensity-modulated-proton-therapy-planning-to-account-for-range-and-patient-setup-uncertainties
#4
Y An, M Bues, S Schild, W Liu
PURPOSE: We propose to apply a robust optimization model based on fuzzy-logic constraints in the intensity-modulated proton therapy (IMPT) planning subject to range and patient setup uncertainties. The purpose is to ensure the plan robustness under uncertainty and obtain the best trade-off between tumor dose coverage and organ-at-risk(OAR) sparing. METHODS: Two IMPT plans were generated for 3 head-and-neck cancer patients: one used the planning target volume(PTV) method; the other used the fuzzy robust optimization method...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28044238/vaporize-anatomically-vaporize-or-enucleate-the-prostate-the-flexible-use-of-the-greenlight-laser
#5
Luca Cindolo, Lorenzo Ruggera, Paolo Destefanis, Claudio Dadone, Giovanni Ferrari
PURPOSES: GreenLight laser has gained increasing acceptance as a less invasive treatment for lower urinary tract symptoms due to benign prostatic hyperplasia (BPH/LUTS). Three surgical options were developed: standard photovaporization (PVP), anatomical PVP and GreenLight enucleation of prostate (GreenLEP); however, literature lacks a direct comparison among the procedures. Aim of the present study is to compare the three techniques in a multicentre series of patients. METHODS: Data were collected from consecutive patients with indication to surgical management of BPH/LUTS in five institutions...
January 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28034614/system-dynamics-applied-to-closed-loop-supply-chains-of-desktops-and-laptops-in-brazil-a-perspective-for-social-inclusion-of-waste-pickers
#6
Verônica Ghisolfi, Gisele de Lorena Diniz Chaves, Renato Ribeiro Siman, Lúcia Helena Xavier
The structure of reverse logistics for waste electrical and electronic equipment (WEEE) is essential to minimize the impacts of their improper disposal. In this context, the Brazilian Solid Waste Policy (BSWP) was a regulatory milestone in Brazil, submitting WEEE to the mandatory implementation of reverse logistics systems, involving the integration of waste pickers on the shared responsibility for the life cycle of products. This article aims to measure the impact of such legal incentives and the bargaining power obtained by the volume of collected waste on the effective formalization of waste pickers...
December 26, 2016: Waste Management
https://www.readbyqxmd.com/read/28029166/influence-of-cooling-face-masks-on-nasal-air-conditioning-and-nasal-geometry
#7
J Lindemann, T Hoffmann, A Koehl, E M Walz, F Sommer
INTRODUCTION: Nasal geometries and temperature of the nasal mucosa are the primary factors affecting nasal air conditioning. Data on intranasal air conditioning after provoking the trigeminal nerve with a cold stimulus simulating the effects of an arctic condition is still missing. The objective was to investigate the influence of skin cooling face masks on nasal air conditioning, mucosal temperature and nasal geometry. METHODS: Standardized in vivo measurements of intranasal air temperature, humidity and mucosal temperature were performed in 55 healthy subjects at defined detection sites before and after wearing a cooling face mask...
December 28, 2016: Rhinology
https://www.readbyqxmd.com/read/28027645/biocarriers-improve-bioaugmentation-efficiency-of-a-rapid-sand-filter-for-the-treatment-of-2-6-dichlorobenzamide-contaminated-drinking-water
#8
Benjamin Horemans, Bart Raes, Johanna Vandermaesen, Yanti Simanjuntak, Hannelore Brocatus, Jeroen T'Syen, Julie Degryse, Jos Boonen, Janneke Wittebol, Ales Lapanje, Sebastian R Sørensen, Dirk Springael
Aminobacter sp. MSH1 immobilized in an alginate matrix in porous stones was tested in a pilot system as an alternative inoculation strategy to the use of free suspended cells for biological removal of micropollutant concentrations of 2,6-dichlorobenzamide (BAM) in drinking water treatment plants (DWTPs). BAM removal rates and MSH1 cell numbers were recorded during operation and assessed with specific BAM degradation rates obtained in lab conditions using either freshly grown cells or starved cells to explain reactor performance...
January 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27995676/double-core-shell-si-c-sio2-for-anode-material-of-lithium-ion-batteries-with-excellent-cycling-stability
#9
Tao Yang, Xiaodong Tian, Xiao Li, Kai Wang, Zhanjun Liu, Quangui Guo, Yan Song
Lithium-ion batteries (LIBs) anodes based on silicon (Si) suffer from severe capacity decay because of the volume expansion caused by the formation of Li15Si4 alloy. In this paper, we prepared the double core-shell Si@C@SiO2 nanostructure by introducing robust silica (SiO2) shell onto the surface of Si@C core-shell nanoparticle through modified StÖber method. The carbon layer alleviates the big pressure during the initial lithiation in a slight degree. Then the silica shell restricts the lithiation degree of Si and thus guarantees the structural integrity avoiding the further decay of capacity because of the formation of instable solid-electrolyte interphase (SEI) films...
December 20, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27990136/non-selective-separation-of-bacterial-cells-with-magnetic-nanoparticles-facilitated-by-varying-surface-charge
#10
Xin-Lei Gao, Ming-Fei Shao, Yi-Sheng Xu, Yi Luo, Kai Zhang, Feng Ouyang, Ji Li
Recovering microorganisms from environmental samples is a crucial primary step for understanding microbial communities using molecular ecological approaches. It is often challenging to harvest microorganisms both efficiently and unselectively, guaranteeing a similar microbial composition between original and separated biomasses. A magnetic nanoparticles (MNPs) based method was developed to effectively separate microbial biomass from glass fiber pulp entrapped bacteria. Buffering pH and nanoparticle silica encapsulation significantly affected both biomass recovery and microbial selectivity...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27955892/sampling-only-ten-microliters-of-whole-blood-for-the-quantification-of-poorly-soluble-drugs-itraconazole-as-case-study
#11
Justine Thiry, Brigitte Evrard, Gwenaël Nys, Marianne Fillet, Miranda G M Kok
Nowadays in animal studies, it is important to comply with the so-called Three Rs rule by replacing or reducing the number of tested animals. Volumetric absorptive microsampling (VAMS) can be used to collect small quantities (10 or 20μL) of whole blood, thereby limiting the amount of animals needed. In this study, a quantitative method was developed and subsequently validated for the poorly soluble drug itraconazole (ITZ) using VAMS and ultra-high performance liquid chromatography (UHPLC) coupled to tandem mass spectrometry (MS)...
January 6, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27932867/clustering-algorithms-their-application-to-gene-expression-data
#12
REVIEW
Jelili Oyelade, Itunuoluwa Isewon, Funke Oladipupo, Olufemi Aromolaran, Efosa Uwoghiren, Faridah Ameh, Moses Achas, Ezekiel Adebiyi
Gene expression data hide vital information required to understand the biological process that takes place in a particular organism in relation to its environment. Deciphering the hidden patterns in gene expression data proffers a prodigious preference to strengthen the understanding of functional genomics. The complexity of biological networks and the volume of genes present increase the challenges of comprehending and interpretation of the resulting mass of data, which consists of millions of measurements; these data also inhibit vagueness, imprecision, and noise...
2016: Bioinformatics and Biology Insights
https://www.readbyqxmd.com/read/27904836/pulmonary-complications-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma
#13
Quan M Nhu, Harry Knowles, Paul J Pockros, Catherine T Frenette
Transarterial chemoembolization (TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma (HCC). Post-TACE pulmonary complications resulting in acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous (AV) shunts within the hyper-vascular HCC...
2016: World Journal of Respirology
https://www.readbyqxmd.com/read/27895733/improved-laparoscopic-nephron-sparing-surgery-for-renal-cell-carcinoma-based-on-the-precise-anatomy-of-the-nephron
#14
Gang Guo, Wei Cai, Xu Zhang
The aim of the present study was to investigate a method of laparoscopic nephron-sparing surgery (LNSS) for renal cell carcinoma (RCC) based on the precise anatomy of the nephron, and to decrease the incidence of hemorrhage and urinary leakage. Between January 2012 and December 2013, 31 patients who presented to the General Hospital of the People's Liberation Army (Beijing, China) were treated for RCC. The mean tumor size was 3.4±0.7 cm in diameter (range, 1.2-6.0 cm). During surgery, the renal artery was blocked, and subsequently, an incision in the renal capsule and renal cortex was performed, at 3-5 mm from the tumor edge...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27879966/andrological-complications-following-retroperitoneal-lymphnode-dissection-for-testicular-cancer-a-narrative-review
#15
Alessandro Crestani, Francesco Esperto, Marta Rossanese, Gianluca Giannarini, Nicola Nicolai, Vincenzo Ficarra
Retroperitoneal lymphnode dissection (RPLND) is a fundamental surgical step in the treatment of testicular cancer. Nowadays primary RPLND has partially lost its role in favour of active surveillance (for low risk stage I disease) and short cycle chemotherapy in non-seminomatous germ cell tumour (NSGCT). Conversely, postchemotherapy-RPLND (PC-RPLND) remains the standard treatment for residual masses after chemotherapy. In consideration of curability rate of testicular cancer and the life expectancy of testicular cancer survivors the identification and the prevention of andrological complications became fundamental...
November 23, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27847443/increasing-injection-frequency-enhances-the-survival-of-injected-bone-marrow-derived-mesenchymal-stem-cells-in-a-critical-limb-ischemia-animal-model
#16
Woong Chol Kang, Pyung Chun Oh, Kyounghoon Lee, Taehoon Ahn, Kyunghee Byun
Critical limb ischemia (CLI) is one of the most severe forms of peripheral artery diseases, but current treatment strategies do not guarantee complete recovery of vascular blood flow or reduce the risk of mortality. Recently, human bone marrow derived mesenchymal stem cells (MSCs) have been reported to have a paracrine influence on angiogenesis in several ischemic diseases. However, little evidence is available regarding optimal cell doses and injection frequencies. Thus, the authors undertook this study to investigate the effects of cell dose and injection frequency on cell survival and paracrine effects...
November 2016: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/27809481/achieving-fully-reversible-conversion-in-moo3-for-lithium-ion-batteries-by-rational-introduction-of-comoo4
#17
Wei Wang, Jinwen Qin, Zhigang Yin, Minhua Cao
Electrode materials based on conversion reactions with lithium ions generally show much higher energy density. One of the main challenges in the design of these electrode materials is to improve initial Coulombic efficiency and alleviate the volume changes during the lithiation-delithiation processes. Here, we achieve fully reversible conversion in MoO3 as an anode for lithium ion batteries by the hybridization of CoMoO4. The porous MoO3-CoMoO4 microspheres are constructed by homogeneously dispersed MoO3 and CoMoO4 subunits and their lithiation/delithiation processes were studied by ex situ TEM to reveal the mechanism of the reversible conversion reaction...
November 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27794079/volume-targeted-versus-pressure-limited-noninvasive-ventilation-in-subjects-with-acute-hypercapnic-respiratory-failure-a-multicenter-randomized-controlled-trial
#18
Zhixin Cao, Zujin Luo, Anna Hou, Qingrong Nie, Baoyuan Xie, Xiaojie An, Zifen Wan, Xianwei Ye, Yanju Xu, Xisheng Chen, Honghai Zhang, Zhenyang Xu, Jinxiang Wang, Fucheng An, Pengfei Li, Chunxiao Yu, Yandong Liang, Yongxiang Zhang, Yingmin Ma
BACKGROUND: Volume-targeted noninvasive ventilation (VT-NIV), a hybrid mode that delivers a preset target tidal volume (VT) through the automated adjustment of pressure support, could guarantee a relatively constant target VT over pressure-limited noninvasive ventilation (PL-NIV) with fixed-level pressure support. Whether VT-NIV is more effective in improving ventilatory status in subjects with acute hypercapnic respiratory failure (AHRF) remains unclear. Our aim was to verify whether, in comparison with PL-NIV, VT-NIV would be more effective in correcting hypercapnia, hence reducing the need for intubation and improving survival in subjects with AHRF...
November 2016: Respiratory Care
https://www.readbyqxmd.com/read/27727026/best-practice-for-perioperative-management-of-patients-with-cytoreductive-surgery-and-hipec
#19
C Raspé, L Flöther, R Schneider, M Bucher, P Piso
Due to the significantly improved outcome and quality of life of patients with different tumor entities after cytoreductive surgery (CRS) and HIPEC, there is an increasing number of centers performing CRS and HIPEC procedures. As this procedure is technically challenging with potential high morbidity and mortality, respectively, institutional experience also in the anesthetic and intensive care departments is essential for optimal treatment and prevention of adverse events. Clinical pathways have to be developed to achieve also good results in more comorbid patients with border line indications and extensive surgical procedures...
September 28, 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27687346/comparison-of-volume-controlled-ventilation-and-pressure-controlled-ventilation-volume-guaranteed-during-laparoscopic-surgery-in-trendelenburg-position
#20
Osama M Assad, Ayman A El Sayed, Mohamed A Khalil
STUDY OBJECTIVE: To analyze the effects of pressure-controlled ventilation-volume guaranteed (PCV-VG) and volume controlled ventilation (VCV) on airway pressures and respiratory and circulatory indicators during laparoscopic surgery in Trendelenburg position. DESIGN: Prospective randomized comparative clinical study. SETTING: Tertiary hospital. PATIENTS: Forty ASA physical status 1 and 2 patients who underwent elective laparoscopic surgery in Trendelenburg position...
November 2016: Journal of Clinical Anesthesia
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