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https://www.readbyqxmd.com/read/28919003/inter-observer-agreement-in-gtv-delineation-of-bone-metastases-on-ct-and-impact-of-mr-imaging-a-multicenter-study
#1
A S Gerlich, J M van der Velden, A N T J Kotte, C L Tseng, G Fanetti, W S C Eppinga, N Kasperts, M P W Intven, F A Pameijer, M E P Philippens, H M Verkooijen, E Seravalli
BACKGROUND AND PURPOSE: The use of Stereotactic Body Radiotherapy (SBRT) for bone metastases is increasing rapidly. Therefore, knowledge of the inter-observer differences in tumor volume delineation is essential to guarantee precise dose delivery. The aim of this study is to compare inter-observer agreement in bone metastases delineated on different imaging modalities. MATERIAL AND METHODS: Twenty consecutive patients with bone metastases treated with SBRT were selected...
September 14, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28912258/frank-starling-mechanism-and-short-term-adjustment-of-cardiac-flow
#2
José Guilherme Chaui-Berlinck, Luiz Henrique Alves Monteiro
The Frank-Starling Law of the heart is a filling-force mechanism (FFm), a positive relationship between the distension of a ventricular chamber and its force of ejection, and such a mechanism is found across all the studied vertebrate lineages. The functioning of the cardiovascular system is usually described by means of the cardiac and vascular functions, the former related to the contractility of the heart and the latter related to the after-load imposed to the ventricle. The crossing of these functions is the so-called operation point, and the FFm is supposed to play a stabilizing role for the short-term variations in the working of the system...
September 14, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28899649/small-field-characterization-of-a-nanochamber-prototype-under-flattening-filter-free-photon-beams
#3
G Reggiori, A Stravato, P Mancosu, F Lobefalo, L Paganini, F Zucconi, V Palumbo, A Gaudino, M Scorsetti, S Tomatis
INTRODUCTION: Nanochambers present some advantages in terms of energy independence and absolute dose measurement for small field dosimetry in the SBRT scenario. Characterization of a micro-chamber prototype was carried out both under flattened and flattening-filter-free (FFF) beams with particular focus on stem effect. METHODS: The study included characterization of leakage and stem effects, dose rate and dose per pulse dependence, measurement of profiles, and percentage depth doses (PDDs)...
September 9, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28836380/comparison-of-human-umbilical-cord-blood-processing-with-or-without-hydroxyethyl-starch
#4
Milad Souri, Mahin Nikougoftar Zarif, Mahboobeh Rasouli, Khadijeh Golzadeh, Mozhdeh Nakhlestani Hagh, Nasim Ezzati, Kamran Atarodi
BACKGROUND: Umbilical cord blood (UCB) processing with hydroxyethyl starch (HES) is the most common protocol in the cord blood banks. The quality of UCB volume reduction was guaranteed by minimum manipulation of cord blood samples in the closed system. This study aimed to analyze and compare cell recovery and viability of UCB processed using the Sepax automated system in the presence and absence of HES. STUDY DESIGN AND METHODS: Thirty UCB bags with a total nucleated cell (TNC) count of more than 2...
August 23, 2017: Transfusion
https://www.readbyqxmd.com/read/28834435/thermometry-of-plasmonic-heating-by-inelastic-electron-tunneling-spectroscopy-iets
#5
Nirit Nachman, Yoram Selzer
The electronic and lattice heating accompanying plasmonic structures under illumination is suggested to be utilized in a broad range of thermoplasmonic applications. Specifically, in molecular electronics precise determination of the temperature of illuminated junctions is crucial, because the temperature-dependent energy distribution of charge carriers in the leads affects the possibility to steer various light-controlled conductance processes. Existing optical methods to characterize the local temperature in all these applications lack the spatial resolution to probe the few nanometers in size hot spots and therefore typically report average values over a diffraction limited length scale...
September 13, 2017: Nano Letters
https://www.readbyqxmd.com/read/28833568/polymer-microstructures-through-two-photon-crosslinking
#6
David Schwärzle, Xiaoqang Hou, Oswald Prucker, Jürgen Rühe
Two-photon crosslinking of polymers (2PC) is proposed as a novel method for the fabrication of freestanding microstructures via two-photon lithography. During this process in the confocal volume, two-photon absorption leads to (formal) C,H-insertion reactions, and consequently to a strictly localized crosslinking of the polymer. To achieve this, the polymer is coated as a solvent-free (glassy) film onto an appropriate substrate, and the desired microstructure is written by 2PC into this glass. In all regions outside of the focal volume where no two-photon process occurs, the polymer remains uncrosslinked and can be washed away during a developing process...
August 18, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28795220/achieving-and-maintaining-lung-volume-in-the-preterm-infant-from-the-first-breath-to-the-nicu
#7
REVIEW
Gianluca Lista, Andrés Maturana, Fernando R Moya
The main goal for the neonatologist is to facilitate the adaptation to extra-uterine life during initial transition, while minimizing lung injury opening and protecting the premature lung from the first breath onwards. An appropriate management from birth should lead to the achievement of an early functional residual capacity (FRC), and the following steps should aim at maintaining an adequate lung volume. To date, different strategies are available to optimize fetal-neonatal transition and promote lung recruitment...
August 10, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28794965/efficacy-of-lung-volume-optimization-maneuver-monitored-by-optoelectronic-pletismography-in-the-management-of-congenital-diaphragmatic-hernia
#8
G Lista, I Bresesti, F Cavigioli, F Castoldi, E Lupo, A LoMauro, A Aliverti
Newborns affected by congenital diaphragmatic hernia (CDH) need cardio-respiratory stabilization before undergoing surgical repair. Open lung strategy is a well-established approach to optimize lung volume in preterm infants with Respiratory Distress Syndrome (RDS), using both High Frequency Oscillatory Ventilation (HFOV) and Conventional Mechanical Ventilation (CMV). We report a case of left CDH with severe lung hypoplasia, managed applying open lung strategy in HFOV (pre-surgery period) and in Assist-Control with Volume Guarantee (post-surgery period), guided by SpO2 changes, TcPO2 and TcPCO2 monitoring...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/28765493/variability-of-tidal-volume-in-patient-triggered-mechanical-ventilation-in-ards
#9
Sophie Perinel-Ragey, Loredana Baboi, Claude Guérin
BACKGROUND: Limiting tidal volume (VT) in patients with ARDS may not be achieved once patient-triggered breaths occur. Furthermore, ICU ventilators offer numerous patient-triggered modes that work differently across brands. We systematically investigated, using a bench model, the effect of patient-triggered modes on the size and variability of VT at different breathing frequencies (f), patient effort, and ARDS severity. METHODS: We used a V500 Infinity ICU ventilator connected to an ASL 5000 lung model whose compliance was mimicking mild, moderate, and severe ARDS...
August 1, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28758740/yolk-shell-or-concave-cubic-nio-co3o4-c-nanocomposites-derived-from-metal-organic-frameworks-for-advanced-lithium-ion-battery-anodes
#10
Gang Huang, Dongming Yin, Feifei Zhang, Qian Li, Limin Wang
Novel hybrid metal oxides with advanced architectures are extensively pursued to achieve synergetic properties with respect to improved lithium-ion storage properties. Here, rationally designed yolk@shell or concave NiO-Co3O4@C (YNCC or CNCC) nanocubes have been fabricated by the simple and versatile thermolysis-induced transformation of metal-organic frameworks (MOFs), aimed at simultaneously addressing the capacity fade and conductivity deficiency of metal oxides. The as-prepared nanocomposites with plentiful hierarchical pores integrate the distinct functionalities of the ternary components: NiO and Co3O4 as the major active materials can guarantee high capacity, while carbon can improve the conductivity and accommodate volume changes...
July 31, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28743149/-the-influence-of-anesthesia-on-perioperative-outcome-in-children-institutional-and-individual-factors
#11
Frank Fideler, Christian Grasshoff
The perioperative care of children is challenging for health care providers. Since anesthetists cannot affect the nature of the disease and have hardly an impact on the decision for surgery we summarized in this review individual and institutional factors for improving perioperative outcome by anesthetists. Individual factors include the level of education and the professional experience of the anesthetist as well as an anesthetic management that is focused on the maintenance of an adequate cerebral perfusion...
July 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28741600/coverage-based-constraints-for-imrt-optimization
#12
H Mescher, S Ulrich, M Bangert
Radiation therapy treatment planning requires an incorporation of uncertainties in order to guarantee an adequate irradiation of the tumor volumes. In current clinical practice, uncertainties are accounted for implicitly with an expansion of the target volume according to generic margin recipes. Alternatively, it is possible to account for uncertainties by explicit minimization of objectives that describe worst-case treatment scenarios, the expectation value of the treatment or the coverage probability of the target volumes during treatment planning...
September 5, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28698268/effects-of-volume-guaranteed-ventilation-combined-with-two-different-modes-in-preterm-infants
#13
Sezin Unal, Ebru Ergenekon, Selma Aktas, Nilgun Altuntas, Serdar Beken, Ebru Kazanci, Ferit Kulali, Ozlem Gulbahar, Ibrahim M Hirfanoglu, Esra Onal, Canan Turkyilmaz, Esin Koc, Yildiz Atalay
BACKGROUND: Volume-controlled ventilation modes have been shown to reduce duration of mechanical ventilation, incidence of chronic lung disease, failure of primary mode of ventilation, hypocarbia, severe intraventricular hemorrhage, pneumothorax, and periventricular leukomalacia in preterm infants when compared with pressure limited ventilation modes. Volume-guarantee (VG) ventilation is the most commonly used mode for volume-controlled ventilation. Assist control, pressure-support ventilation (PSV), and synchronized intermittent mandatory ventilation (SIMV) can be combined with VG; however, there is a lack of knowledge on the superiority of each regarding clinical outcomes...
July 11, 2017: Respiratory Care
https://www.readbyqxmd.com/read/28659362/volume-guaranteed-accuracy-of-a-volume-targeted-ventilation-mode-in-infants
#14
Olivia Farrell, Elizabeth J Perkins, Don Black, Martijn Miedema, Joel Don Paul, Prue M Pereira-Fantini, David Gerald Tingay
OBJECTIVES: Volume-targeted ventilation (VTV) is widely used and may reduce lung injury, but this assumes the clinically set tidal volume (VTset) is accurately delivered. This prospective observational study aimed to determine the relationship between VTset, expiratory VT (VTe) and endotracheal tube leak in a modern neonatal -volume-targeted ventilator (VTV) and the resultant partial arterial pressure of carbon dioxide (PaCO2) relationship with and without VTV. DESIGN: Continuous inflations were recorded for 24 hours in 100 infants, mean (SD) 34 (4) weeks gestation and 2483 (985) g birth weight, receiving synchronised mechanical ventilation (SLE5000, SLE, UK) with or without VTV and either the manufacturer's V4 (n=50) or newer V5 (n=50) VTV algorithm...
June 28, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28651638/comparing-regional-models-of-congenital-bleeding-disorders-preliminary-steps-in-the-italian-context
#15
Sabina Nuti, Chiara Seghieri, Francesco Niccolai, Federica Vasta, Giuliano Grazzini
BACKGROUND: Among these diseases, congenital bleeding disorders (CBD) represent a significant societal burden in terms of high morbidity costs and health outcomes. In Italy, the organization and provision of health care is a regional responsibility and regions must assure equity and quality to all their residents. This is also true for CBD care which is provided by 54 multidisciplinary Hemophilia Treatment Centers (HTCs) distributed among the regions. With the present study, we intend to stimulate a debate on the effect that the decentralization process have in the delivery of services to CBD patients across Italy...
June 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28645964/the-predictive-value-of-serial-changes-in-diaphragm-function-during-the-spontaneous-breathing-trial-for-weaning-outcome-a-study-protocol
#16
Pengmin Zhou, Zhongheng Zhang, Yucai Hong, Huabo Cai, Hui Zhao, Peifeng Xu, Yiming Zhao, Shengping Lin, Xuchang Qin, JiaWei Guo, Yun Pan, Junru Dai
INTRODUCTION: There is a variety of tools being used in clinical practice for the prediction of weaning success from mechanical ventilation. However, their diagnostic performances are less than satisfactory. The purpose of this study is to investigate the value of serial changes in diaphragm function measured by ultrasound during the spontaneous breathing trial (SBT) as a weaning predictor. METHODS AND ANALYSIS: This is a prospective observational study conducted in a 10-bed medical emergency intensive care unit (EICU) in a university-affiliated hospital...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28635185/antipulverization-electrode-based-on-low-carbon-triple-shelled-superstructures-for-lithium-ion-batteries
#17
Lianhai Zu, Qingmei Su, Feng Zhu, Bingjie Chen, Huanhuan Lu, Chengxin Peng, Ting He, Gaohui Du, Pengfei He, Kai Chen, Shihe Yang, Jinhu Yang, Huisheng Peng
The realization of antipulverization electrode structures, especially using low-carbon-content anode materials, is crucial for developing high-energy and long-life lithium-ion batteries (LIBs); however, this technology remains challenging. This study shows that SnO2 triple-shelled hollow superstructures (TSHSs) with a low carbon content (4.83%) constructed by layer-by-layer assembly of various nanostructure units can withstand a huge volume expansion of ≈231.8% and deliver a high reversible capacity of 1099 mAh g(-1) even after 1450 cycles...
September 2017: Advanced Materials
https://www.readbyqxmd.com/read/28633111/drought-avoiding-plants-with-low-water-use-can-achieve-high-rainfall-retention-without-jeopardising-survival-on-green-roofs
#18
Christopher Szota, Claire Farrell, Nicholas S G Williams, Stefan K Arndt, Tim D Fletcher
Green roofs are increasingly being used among the suite of tools designed to reduce the volume of surface water runoff generated by cities. Plants provide the primary mechanism for restoring the rainfall retention capacity of green roofs, but selecting plants with high water use is likely to increase drought stress. Using empirically-derived plant physiological parameters, we used a water balance model to assess the trade-off between rainfall retention and plant drought stress under a 30-year climate scenario...
June 17, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28613341/three-dimensional-interpenetrating-mesoporous-carbon-confining-sno2-particles-for-superior-sodiation-desodiation-properties
#19
Jagabandhu Patra, Purna Chandra Rath, Cheng-Hsein Yang, Diganta Saikia, Hsien-Ming Kao, Jeng-Kuei Chang
Nanosized SnO2 particles (∼2 nm in diameter) are embedded in ordered mesoporous CMK-8 carbon with unique three-dimensional interconnected pore channels and used as a sodium-ion battery (NIB) anode. Due to the CMK-8 confinement effects, the growth of SnO2 is suppressed during synthesis, leading to high material electroactivity. The CMK-8 not only serves as an electronic conducting pathway, but also creates interpenetrating tunnels, which guarantee electrolyte accessibility and thus Na(+) transport throughout the electrode...
June 29, 2017: Nanoscale
https://www.readbyqxmd.com/read/28582266/a-beam-monitoring-and-validation-system-for-continuous-line-scanning-in-proton-therapy
#20
Grischa Klimpki, Serena Psoroulas, Christian Bula, Urs Rechsteiner, Michael Eichin, Damien Weber, Antony Lomax, David Meer
Line scanning represents a faster and potentially more flexible form of pencil beam scanning than conventional <i>step-and-shoot</i> irradiations. It seeks to minimize dead times in beam delivery whilst preserving the possibility to modulate the dose at any point in the target volume. Our second generation proton gantry features irradiations in line scanning mode, but it still lacks a dedicated monitoring and validation system that guarantees patient safety throughout beam delivery. We report on its design and implementation in this paper...
June 5, 2017: Physics in Medicine and Biology
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