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https://www.readbyqxmd.com/read/28818763/the-qualitative-and-quantitative-image-analysis-of-mr-imaging-in-patients-with-acute-on-chronic-liver-failure
#1
Tae Wook Kang, Mimi Kim, Young Kon Kim, Seong Hyun Kim, Dong Hyun Sinn, Kyunga Kim
PURPOSE: To evaluate the distinctive features of ACLF and chronic liver disease (CLD) on MR images using quantitative and qualitative analyses. METHODS: Twelve patients with ACLF and 36 patients with CLD who had undergone MR images were included. MR imaging findings from both groups were assessed. RESULTS: Gallbladder edema, esophageal varix, and ascites were significantly more prevalent in the ACLF group (all P-values <0.05). The liver to muscle SI ratio on T2-WI was significantly higher in the ACLF group (P=0...
August 10, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/28802347/using-quality-improvement-tools-to-reduce-chronic-lung-disease
#2
REVIEW
Alan Peter Picarillo, Waldemar Carlo
Rates of chronic lung disease (CLD) in very low birthweight infants have not decreased at the same pace as other neonatal morbidities over the past 20 years. Multifactorial causes of CLD make this common morbidity difficult to reduce, although there have been several successful quality improvement (QI) projects in individual neonatal intensive care units. QI projects have become a mainstay of neonatal care over the past decade, with an increasing number of publications devoted to this topic. A specific QI project for CLD must be based on best available evidence in the medical literature, expert recommendations, or based on work by previous QI initiatives...
September 2017: Clinics in Perinatology
https://www.readbyqxmd.com/read/28758386/active-sites-of-o2-evolving-chlorite-dismutases-probed-by-halides-hydroxides-and-new-iron-ligand-vibrational-correlations
#3
Zachary Geeraerts, Kenton R Rodgers, Jennifer DuBois, Gudrun S Lukat-Rodgers
O2-evolving chlorite dismutases (Clds) fall into two subfamilies, which efficiently convert ClO2(-) to O2 and Cl(-). The Cld from Dechloromonas aromatica (DaCld) represents the chlorite-decomposing homopentameric enzymes found in perchlorate and chlorate respiring bacteria. The Cld from the Gram-negative, human pathogen Klebsiella pneumoniae (KpCld) is representative of the second subfamily, comprising homodimeric enzymes having truncated N-termini. Here steric and nonbonding properties of the DaCld and KpCld active sites have been probed via kinetic, thermodynamic and spectroscopic behaviors of their fluorides, chlorides and hydroxides...
July 31, 2017: Biochemistry
https://www.readbyqxmd.com/read/28752475/use-of-statins-in-patients-with-chronic-liver-disease-and-cirrhosis-current-views-and-prospects
#4
REVIEW
Jose Ignacio Vargas, Marco Arrese, Vijay H Shah, Juan Pablo Arab
PURPOSE OF REVIEW: The purpose of this study is to analyze the current evidence regarding the use of statins in patients with chronic liver disease and cirrhosis. RECENT FINDINGS: Chronic liver disease (CLD), cirrhosis, and its complications, including hepatocellular carcinoma (HCC), are significant public health problems. The use of statins in patients with CLD has been a matter of concern, and physicians are often reluctant to its prescription in these patients...
September 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/28723979/outcome-and-nutritional-assessment-of-chronic-liver-disease-patients-using-anthropometry-and-subjective-global-assessment
#5
Gonçalo Nunes, Carla Adriana Santos, Rita Barosa, Cristina Fonseca, Ana Teresa Barata, Jorge Fonseca
BACKGROUND: Protein-calorie malnutrition is common in chronic liver disease (CLD) but adequate clinical tools for nutritional assessment are not defined. OBJECTIVE: In CLD patients, it was aimed: 1. Characterize protein-calorie malnutrition; 2. Compare several clinical, anthropometric and functional tools; 3. Study the association malnutrition/CLD severity and malnutrition/outcome. METHODS: Observational, prospective study. Consecutive CLD ambulatory/hospitalised patients were recruited from 01-03-2012 to 31-08-2012, studied according with age, gender, etiology, alcohol consumption and CLD severity defined by Child-Turcotte-Pugh...
July 6, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28723966/activated-carbon-a-useful-medium-to-bind-chlordecone-in-soil-and-limit-its-transfer-to-growing-goat-kids
#6
Sarah Yehya, Matthieu Delannoy, Agnès Fournier, Moomen Baroudi, Guido Rychen, Cyril Feidt
Chlordecone (Kepone) (CLD) is a highly persistent pesticide which was extensively used in the French West Indies; high levels of CLD can still currently be found in large agricultural areas. As CLD transfers from soil to animals mainly via involuntary ingestion, the consumption of foodstuffs derived from animals raised in contaminated areas may significantly contribute to exposure of humans to CLD. The present study was designed to test the efficacy of two different activated carbons (ACs) sources in limiting CLD transfer from soil to animal...
2017: PloS One
https://www.readbyqxmd.com/read/28702132/measuring-levels-of-osteopontin-as-potential-biomarker-for-hepatocellular-carcinoma-in-syrian-patients
#7
Sara Al-Zoubi, Ahmad Wassouf, Almoutassem Billah Zetoune
AIM: This study aims to evaluate plasma osteopontin (OPN) levels as a potential biomarker for hepatocellular carcinoma (HCC). BACKGROUND: Osteopontin (OPN) is a secreted glycoprotein that is associated with tumorigenesis and metastasis. METHODS: We measured plasma levels of OPN in 26 HCC patients, 27 patients with chronic liver diseases (CLD), and 15 healthy control individuals using a standardized ELISA kit. RESULTS: The mean plasma OPN level was significantly higher in the HCC group than the CLD group or the normal control group (p-value =0...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28699005/study-of-chlordecone-desorption-from-activated-carbons-and-subsequent-dechlorination-by-reduced-cobalamin
#8
Ronald Ranguin, Axelle Durimel, Reeka Karioua, Sarra Gaspard
Since 1972, the French departments of Guadeloupe and Martinique have intensively used organochlorinated pesticides such as chlordecone (CLD) and hexachlorocyclohexane (HCH) isomers to prevent the proliferation of banana weevil (Cosmopolite sordidus). These molecules are stable in the environment, leading to a continuous contamination of soils, water, and food chain in the banana-producing areas. In these polluted areas, water treatment plants are equipped with activated carbon (AC) filters. In order to improve treatment of CLD-contaminated waters by AC, CLD adsorption and desorption kinetic studies are carried out using different ACs produced from sugar cane bagasse as adsorbents and subsequent CLD degradation is performed using reduced vitamin B12 (VB12)...
July 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28697629/culturally-and-linguistically-diverse-student-and-family-perspectives-of-aac
#9
Saili S Kulkarni, Jessica Parmar
Augmentative and alternative communication (AAC) devices are important for nonverbal students with disabilities to communicate with the verbal world. AAC devices provide access to academic and social opportunities for students with disabilities. With the changing demographics of schools and an emphasis on meaningful, culturally relevant instruction for all students, it is important to consider how AAC devices are utilized and perceived by individuals from culturally and linguistically diverse (CLD) backgrounds and their families...
July 12, 2017: Augmentative and Alternative Communication: AAC
https://www.readbyqxmd.com/read/28697444/an-efficient-electrochemiluminescence-amplification-strategy-via-bis-co-reaction-accelerator-for-sensitive-detection-of-laminin-to-monitor-overnutrition-associated-liver-damage
#10
Jing Zhao, Wen-Bin Liang, Yan-Mei Lei, Yang-Xue Ou, Ya-Qin Chai, Ruo Yuan, Ying Zhuo
With the world wildly improvement in dietary and nutrition status, it couldn't be ignored that the chronic liver disease (CLD) resulted from the overnutrition. In order to estimate nutrition status for healthy living, an efficient and sensitive electrochemiluminescence (ECL) sandwich immunosensor of laminin (LN), a marker of CLD, was proposed for early diagnosis of CLD. In this work, the anodic ECL behavior of perylene derivative using H2O2 as co-reactant was demonstrated and the possible ECL mechanism was proposed...
July 3, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28682508/bone-marrow-endothelial-progenitor-cells-activate-hepatic-stellate-cells-and-aggravate-carbon-tetrachloride-induced-liver-fibrosis-in-mice-via-paracrine-factors
#11
Manali Garg, Savneet Kaur, Arpita Banik, Vikash Kumar, Archana Rastogi, Shiv K Sarin, Asok Mukhopadhyay, Nirupma Trehanpati
OBJECTIVES: Bone marrow derived endothelial progenitor cells (BM-EPCs) are increased in chronic liver disease (CLD). Their role in hepatic fibrosis and regeneration remains an area of intense studies. We investigated the migration and secretory functions of BM-EPCs in fibrotic mice liver. MATERIALS AND METHODS: Bone marrow cells from C57BL6-GFP mice were transplanted into the femur of irradiated C57BL6 mice, followed by CCl4 doses for 8 weeks, to develop hepatic fibrosis (n = 36)...
July 6, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28681550/comparison-of-long-term-safety-of-fixed-dose-combinations-azilsartan-medoxomil-chlorthalidone-vs-olmesartan-medoxomil-hydrochlorothiazide
#12
Joel M Neutel, William C Cushman, Eric Lloyd, Bruce Barger, Alison Handley
This 52-week, randomized, open-label study evaluated long-term safety/tolerability of fixed-dose combination azilsartan medoxomil/chlorthalidone (AZL-M/CLD) vs fixed-dose combination olmesartan medoxomil/hydrochlorothiazide (OLM/HCTZ) in patients with essential hypertension (stage 2; clinic systolic blood pressure 160-190 mm Hg). Initial AZL-M/CLD 40/12.5 mg/d (n=418) or OLM/HCTZ 20/12.5 mg/d (n=419) could be uptitrated during weeks 4 to 52 (AZL-M/CLD to 80/25 mg; OLM/HCTZ to 40/25 mg [United States] or 20/25 mg [Europe]) to meet blood pressure targets...
July 6, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28674750/characteristics-of-hypertension-in-premature-infants-with-and-without-chronic-lung-disease-a-long-term-multi-center-study
#13
Randall D Jenkins, Julia K Aziz, Ladawna L Gievers, Harrison M Mooers, Nora Fino, David J Rozansky
BACKGROUND: Many causes for neonatal hypertension in premature infants have been described; however in some cases no etiology can be attributed. Our objectives are to describe such cases of unexplained hypertension and to compare hypertensive infants with and without chronic lung disease (CLD). METHODS: We reviewed all cases of hypertension in premature infants referred from 18 hospitals over 16 years. Inclusion criteria were hypertension occurring at <6 months of age and birth at <37 weeks gestation; the main exclusion criterion was known secondary hypertension...
July 3, 2017: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/28666480/trend-and-causes-of-adult-mortality-in-kersa-health-and-demographic-surveillance-system-kersa-hdss-eastern-ethiopia-verbal-autopsy-method
#14
Wondimye Ashenafi, Frehywot Eshetu, Nega Assefa, Lemessa Oljira, Melkamu Dedefo, Desalew Zelalem, Negga Baraki, Melake Demena
BACKGROUND: The health problems of adults have been neglected in many developing countries, yet many studies in these countries show high rates of premature mortality in adults. Measuring adult mortality and its cause through verbal autopsy (VA) methods is becoming an important process for mortality estimates and is a good indicator of the overall mortality rates in resource-limited settings. The objective of this analysis is to describe the levels, distribution, and trends of adult mortality over time (2008-2013) and causes of adult deaths using VA in Kersa Health and Demographic Surveillance System (Kersa HDSS)...
July 1, 2017: Population Health Metrics
https://www.readbyqxmd.com/read/28659136/risk-of-chronic-liver-disease-in-post-menopausal-women-due-to-body-mass-index-alcohol-and-their-interaction-a-prospective-nested-cohort-study-within-the-united-kingdom-collaborative-trial-of-ovarian-cancer-screening-ukctocs
#15
Paul M Trembling, Sophia Apostolidou, Aleksandra Gentry-Maharaj, Julie Parkes, Andy Ryan, Sudeep Tanwar, Matthew Burnell, Ian Jacobs, Usha Menon, William M Rosenberg
BACKGROUND: We investigated the risk of chronic liver disease (CLD) due to alcohol consumption and body mass index (BMI) and the effects of their interaction in a prospective cohort study of women recruited to the UKCTOCS trial. METHODS: 95,126 post-menopausal women without documented CLD were stratified into 12 groups defined by combinations of BMI (normal, overweight, obese) and alcohol consumption (none, <1-15, 16-20 and ≥21 units/week), and followed for an average of 5...
June 28, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28658720/enteral-lactoferrin-supplementation-for-prevention-of-sepsis-and-necrotizing-enterocolitis-in-preterm-infants
#16
REVIEW
Mohan Pammi, Gautham Suresh
BACKGROUND: Lactoferrin, a normal component of human colostrum and milk, can enhance host defenses and may be effective for prevention of sepsis and necrotizing enterocolitis (NEC) in preterm neonates. OBJECTIVES: Primary objective 1. To assess the safety and effectiveness of lactoferrin supplementation to enteral feeds for prevention of sepsis and NEC in preterm neonates Secondary objectives 1. To determine the effects of lactoferrin supplementation to enteral feeds to prevent neonatal sepsis and/or NEC on duration of positive-pressure ventilation, development of chronic lung disease (CLD) or periventricular leukomalacia (PVL), length of hospital stay to discharge among survivors, and adverse neurological outcomes at two years of age or later2...
June 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28652726/a-novel-scoring-index-by-doppler-echocardiography-for-predicting-severe-pulmonary-hypertension-due-to-chronic-lung-diseases-a-cross-sectional-diagnostic-accuracy-study
#17
Rong Jiang, Cheng Wu, Bigyan Pudasaini, Lan Wang, Qin-Hua Zhao, Rui Zhang, Wen-Hui Wu, Ping Yuan, Zhi-Cheng Jing, Jin-Ming Liu
BACKGROUND: Severe pulmonary hypertension (PH) resulting from a chronic lung disease (CLD) (severe CLD-PH) requires more aggressive treatment due to its increased mortality compared with mild PH. Therefore, we developed a Doppler echocardiography scoring index (ESI) to predict severe CLD-PH. METHODS: A derivation cohort of 107 patients with CLD who underwent echocardiography was classified into two groups, the normal/mild PH group and the severe PH group, based on the right heart catheterization...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28651937/postnatal-steroids-in-extreme-preterm-infants-intra-tracheal-instillation-using-surfactant-as-a-vehicle
#18
REVIEW
L Boel, S Banerjee, M Chakraborty
Chronic Lung Disease (CLD) is a common respiratory morbidity in survivors following extreme preterm birth, and is associated with adverse neurodevelopment in the long term. Besides demographics, multiple risk factors are implicated in the pathogenesis of CLD. However, early lung inflammation appears to be the common pathway that leads to the pathological and clinical changes observed in CLD. Postnatal use of systemic steroids has been successful in reducing the incidence of CLD but resulted in unacceptable adverse neurodevelopmental outcomes...
May 31, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/28651354/cambial-response-of-norway-spruce-to-modified-carbon-availability-by-phloem-girdling
#19
Andrea Winkler, Walter Oberhuber
We tested the hypothesis that increase in carbon (C) availability in Norway spruce saplings (Picea abies (L.) Karst.) intensifies cambial cell division and increases cell lumen diameter (CLD) and cell wall thickness (CWT) when water availability is adequate. To accomplish this, we experimentally subjected 6-year-old P. abies saplings (n = 80 trees) to two levels of soil humidity (watered versus drought conditions) and manipulated tree C status by physically blocking phloem transport at three girdling dates (GDs)...
June 23, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28648940/upregulation-of-inhibitory-signaling-receptor-programmed-death-marker-1-pd-1-in-disease-evolution-from-cutaneous-lymphoid-dyscrasias-to-mycosis-fungoides-and-sezary-s-syndrome
#20
Giang Huong Nguyen, Luke C Olson, Cynthia M Magro
BACKGROUND: Negative immunoregulatory checkpoints impede effective immune responses to tumor and reduce the action of anticancer agents. One such example is programmed death marker-1 (PD-1), an inhibitory signaling receptor expressed on activated and regulatory T-cells. PD-1 expression was reported in a few reports, but the expression profile of PD-1 and mycosis fungoides (MF) remains largely to be characterized. DESIGN: In this study, skin biopsies from 42 prelymphomatous T-cell dyscrasias (CLD), 9 Sezary's syndrome (SS), 103 MF, and 20 CD30+ lymphoproliferative diseases (LPD) were examined for PD-1 expression using immunohistochemistry...
June 2017: Annals of Diagnostic Pathology
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