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https://www.readbyqxmd.com/read/28105526/first-versus-second-year-respiratory-syncytial-virus-prophylaxis-in-chronic-lung-disease-2005-2015
#1
Daniel Y Wang, Abby Li, Bosco Paes, Ian Mitchell, Krista L Lanctôt
: Children aged <2 years with chronic lung disease (CLD) have a 10-fold higher risk for respiratory syncytial virus-positive hospitalization (RSVH) compared to healthy term infants. Based on the updated position statements, we compared respiratory-related illness hospitalization (RIH) and RSVH risks in CLD children who received palivizumab during the first year (FY) versus second year (SY) of life in the Canadian Registry of Palivizumab (CARESS). Demographic data were collected at enrolment and RIH events recorded monthly from 2005 to 2015...
January 20, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28088581/a-stepwise-algorithm-using-a-at-a-glance-first-line-test-for-the-non-invasive-diagnosis-of-advanced-liver-fibrosis-and-cirrhosis
#2
Jérôme Boursier, Victor de Ledinghen, Vincent Leroy, Rodolphe Anty, Sven Francque, Dominique Salmon, Adrien Lannes, Sandrine Bertrais, Frederic Oberti, Isabelle Fouchard-Hubert, Paul Calès
BACKGROUND & AIMS: Chronic liver diseases (CLD) are highly frequent and thus mainly managed by non-hepatologists. Because they lack access to the best non-invasive tests of liver fibrosis, these physicians cannot accurately determine the disease severity and the need for referral to a hepatologist. We aimed to implement an algorithm, comprising a new first-line test usable by all physicians, for the detection of advanced liver fibrosis in all CLD patients. METHODS: Diagnostic study: 3,754 CLD patients with liver biopsy were 2:1 randomized into derivation and validation sets...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28076459/evaluation-of-phenyl-propanedione-on-yellowing-and-chemical-mechanical-properties-of-experimental-dental-resin-based-materials
#3
Dayane Carvalho Ramos Salles de Oliveira, Eduardo José Souza-Junior, Adam Dobson, Ana Rosa Costa Correr, William Cunha Brandt, Mário Alexandre Coelho Sinhoreti
Objective: To evaluate the influence of phenyl-propanedione on yellowing and chemical-mechanical properties of experimental resin-based materials photoactivated using different light curing units (LCUs). Material and Methods: Experimental resin-based materials with the same organic matrix (60:40 wt% BisGMA:TEGDMA) were mechanically blended using a centrifugal mixing device. To this blend, different photoinitiator systems were added in equimolar concentrations with aliphatic amine doubled by wt%: 0...
November 2016: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28058664/elemental-zinc-is-inversely-associated-with-c-reactive-protein-and-oxidative-stress-in-chronic-liver-disease
#4
Md Giash Uddin, Mohammad Salim Hossain, Md Atiqur Rahman, A H M Mazbah Uddin, Md Shafiullah Bhuiyan
Chronic liver disease (CLD) is associated with the destruction of liver parenchyma cell. It is the main cause of morbidity and mortality in most of the developed countries. Oxidative stress and altered levels of different trace elements in serum have been documented for different diseases including inflammation and many liver diseases. This study aims to evaluate the serum level of malondialdehyde (MDA), nitric oxide (NO), antioxidant vitamin C, C-reactive protein (CRP), and zinc (Zn) in CLD patients and to establish a correlation among the study parameters with the severity of inflammatory conditions of CLD...
January 5, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28055049/clinical-outcomes-of-metformin-use-in-populations-with-chronic-kidney-disease-congestive-heart-failure-or-chronic-liver-disease-a-systematic-review
#5
Matthew J Crowley, Clarissa J Diamantidis, Jennifer R McDuffie, C Blake Cameron, John W Stanifer, Clare K Mock, Xianwei Wang, Shuang Tang, Avishek Nagi, Andrzej S Kosinski, John W Williams
Background: Recent changes to the U.S. Food and Drug Administration boxed warning for metformin will increase its use in persons with historical contraindications or precautions. Prescribers must understand the clinical outcomes of metformin use in these populations. Purpose: To synthesize data addressing outcomes of metformin use in populations with type 2 diabetes and moderate to severe chronic kidney disease (CKD), congestive heart failure (CHF), or chronic liver disease (CLD) with hepatic impairment...
January 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28052185/early-administration-of-inhaled-corticosteroids-for-preventing-chronic-lung-disease-in-very-low-birth-weight-preterm-neonates
#6
REVIEW
Vibhuti S Shah, Arne Ohlsson, Henry L Halliday, Michael Dunn
BACKGROUND: Chronic lung disease (CLD) remains a common complication among preterm infants. There is increasing evidence that inflammation plays an important role in the pathogenesis of CLD. Due to their strong anti-inflammatory properties, corticosteroids are an attractive intervention strategy. However, there are growing concerns regarding short- and long-term effects of systemic corticosteroids. Theoretically, administration of inhaled corticosteroids may allow for beneficial effects on the pulmonary system with a lower risk of undesirable systemic side effects...
January 4, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28051253/antioxidant-diet-and-genotyping-as-tools-for-the-prevention-of-liver-disease
#7
R Di Francia, L Rinaldi, M Cillo, E Varriale, G Facchini, C D'Aniello, G Marotta, M Berretta
It is well-known that 75% of risk factors of chronic liver disease (CLD) are related to nutrition. These circumstances potentially progress towards liver steatosis, fibrosis and hepatocellular carcinoma (HCC). It still represents an enormous problem for the economy of public health worldwide. Furthermore, validated prevention programs could be the solution. Recent knowledge in understanding molecular determinants of energy liver metabolism and new genetic markers offers new insights into the pathogenesis of CLD and HCC...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28048644/tu-h-campus-iep3-05-computer-aided-diagnosis-employing-automatically-segmented-color-specific-regions-in-ultrasound-shear-wave-elastography-for-the-assessment-of-chronic-liver-disease
#8
I Gatos, S Tsantis, G C Kagadis
PURPOSE: To assess the role of an automated Computer Aided Diagnosis (CAD) system in differentiation of Healthy Subjects to Chronic Liver Disease (CLD) Patients in terms of liver fibrosis (F0-F4), using Ultrasound Shear Wave Elastography (SWE). METHODS: Clinical Dataset consisted of 125 subjects, 55 Healthy (F0) whom condition was validated with Normal Biochemical Markers and clear Clinical History, and 70 with CLD (F1-F4) whom condition was validated with Liver Biopsy...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048510/su-f-t-499-anatomic-features-for-selection-of-electronic-tissue-compensation-radiotherapy-in-early-stage-breast-cancer-patients-after-breast-conserving-surgery
#9
Y Song, M Zhang, N Yue, L Gan, X Chen, T Zhang, G Ren
PURPOSE: To explore the correlations between anatomic features and dose-volumetric parameters in 3DCRT and eComp whole breast irradiation and identify the feasibility of anatomic parameters to predict the planning method selection. METHODS: We compared the effectiveness between conventional three-dimensional conformal radiotherapy (3DCRT) and electronic tissue compensation (eComp) for whole breast irradiation. 3DCRT and eComp planning techniques were used to generate treatment plans for 60 whole breast patients, respectively...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047154/su-f-t-405-development-of-a-rapid-cardiac-contouring-tool-using-landmark-driven-modeling
#10
C Pelletier, E Mosher, C Lee, C Lee, J Jung
PURPOSE: This study aims to develop a tool to rapidly delineate cardiac substructures for use in dosimetry for large-scale clinical trial or epidemiological investigations. The goal is to produce a system that can semi-automatically delineate nine cardiac structures to a reasonable accuracy within a couple of minutes. METHODS: The cardiac contouring tool employs a Most Similar Atlas method, where a selection criterion is used to pre-select the most similar model to the patient from a library of pre-defined atlases...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039835/toxicokinetics-of-chlordecone-in-goats-implications-for-risk-management-in-french-west-indies
#11
Agnès Fournier, Cyril Feidt, Marie-Laure Lastel, Harry Archimede, Jean-Pierre Thome, Maurice Mahieu, Guido Rychen
The former use of chlordecone (CLD) in the French West Indies has resulted in long-term pollution of soils. CLD is known to be potentially transferred towards animal products of animals reared outdoors, mainly through accidental soil ingestion. Several studies indicate that soil bound CLD is bioavailable when administered to farm animals. Currently there is a need to quantify the level of CLD absorption and its toxicokinetic characteristics in the ruminant and particularly in the goat. These are considered as important farm species in the French West Indies...
December 13, 2016: Chemosphere
https://www.readbyqxmd.com/read/28032285/individual-and-mixture-acute-toxicity-of-model-pesticides-chlordecone-and-pyriproxyfen-in-the-estuarine-copepod-eurytemora-affinis
#12
Elena Legrand, Céline Boulangé-Lecomte, Gwendal Restoux, Gauthier Trémolet, Aurélie Duflot, Joëlle Forget-Leray
Due to the increase in the use of phytosanitary products during the last few decades, the importance to study the effect of pesticide mixtures has been established. In this study, we investigated the acute toxicity of two model insecticides, chlordecone (CLD) and pyriproxyfen (PXF), alone and in mixtures, in the estuarine copepod Eurytemora affinis. After 48 h of exposure, the relative LC50 were 73.24 and 131.61 μg/L for PXF and CLD, respectively. The lower concentration tested (10 μg/L) did not affect the mortality of E...
December 28, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28027602/is-size-the-only-determinant-of-delayed-abdominal-closure-in-pediatric-liver-transplant
#13
Shirin Elizabeth Khorsandi, Arthur William Raven Day, Miriam Cortes, Akash Deep, Anil Dhawan, Hector Vilca-Melendez, Nigel Heaton
The aim was to determine the factors associated with the use of delayed abdominal closure in pediatric liver transplant and whether this affected outcome. From a prospectively maintained database, transplants performed in children (≤ 18 years) were identified (October 2010 - March 2015). Primary abdominal closure was defined as mass closure performed at time of transplant. Delayed abdominal closure was defined as mass closure not initially performed at the same time as transplant. 230 children underwent liver transplantation...
December 27, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/28027429/intrahepatic-angiopoietin-2-correlates-with-chronic-hepatitis-c-progression-and-is-induced-in-hcv-replicon-systems
#14
Ángel Hernández-Bartolomé, Rosario López-Rodríguez, Luisa García-Buey, Samuel Martín-Vílchez, Yolanda Rodríguez-Muñoz, María Jesús Borque, Leticia González-Moreno, Yolanda Real-Martínez, Jorge Mendoza-Ridruejo, Elena Martín-Pérez, Ricardo Moreno-Otero, Paloma Sanz-Cameno
INTRODUCTION & AIMS: Chronic hepatitis C (CHC) is a major cause of cirrhosis and hepatocellular carcinoma and angiogenesis is closely related to the pathogenesis and progression of different chronic liver diseases (CLD). Thus, the intrahepatic expression of angiopoietins 1 and 2 (Ang1 and Ang2), as relevant mediators of pathological angiogenesis in several CLD, was investigated. Additionally, the differential influence of structural and non-structural genomic regions of HCV on the expression of angiopoietins and the possible signaling involved were studied...
December 27, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28019060/development-of-a-simple-predictive-model-for-decreased-skeletal-muscle-mass-in-patients-with-compensated-chronic-liver-disease
#15
Hiroki Nishikawa, Hirayuki Enomoto, Akio Ishii, Yoshinori Iwata, Yuho Miyamoto, Noriko Ishii, Yukihisa Yuri, Ryo Takata, Kunihiro Hasegawa, Chikage Nakano, Takashi Nishimura, Yoh Kazunori, Nobuhiro Aizawa, Yoshiyuki Sakai, Naoto Ikeda, Tomoyuki Takashima, Hiroko Iijima, Shuhei Nishiguchi
AIMS: To develop and validate a simple predictive model using easily obtained clinical parameters to predict decreased skeletal muscle mass (DSMM) in chronic liver disease (CLD) patients (n = 652). METHODS: Study subjects were divided into a training set (n = 326) and a validation set (n = 326). DSMM was diagnosed based on skeletal muscle mass index measured by bioimpedance analysis. Variables significantly associated with DSMM were identified using univariate and multivariate analyses in the training set and used to construct a predictive formula...
December 26, 2016: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/28012669/co-transport-of-chlordecone-and-sulfadiazine-in-the-presence-of-functionalized-multi-walled-carbon-nanotubes-in-soils
#16
Miaoyue Zhang, Irina Engelhardt, Jirka Šimůnek, Scott A Bradford, Daniela Kasel, Anne E Berns, Harry Vereecken, Erwin Klumpp
Batch and saturated soil column experiments were conducted to investigate sorption and mobility of two (14)C-labeled contaminants, the hydrophobic chlordecone (CLD) and the sulfadiazine (SDZ), in the absence or presence of functionalized multi-walled carbon nanotubes (MWCNTs). The transport behaviors of CLD, SDZ, and MWCNTs were studied at environmentally relevant concentrations (0.1-10 mg L(-1)) and they were applied in the column studies at different times. The breakthrough curves and retention profiles were simulated using a numerical model that accounted for the advective-dispersive transport of all compounds, attachment/detachment of MWCNTs, equilibrium and kinetic sorption of contaminants, and co-transport of contaminants with MWCNTs...
February 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28011329/functional-role-of-ccl5-rantes-for-hcc-progression-during-chronic-liver-disease
#17
Antje Mohs, Nadine Kuttkat, Johanna Reißing, Henning Wolfgang Zimmermann, Roland Sonntag, Amanda Proudfoot, Sameh A Youssef, Alain de Bruin, Francisco Javier Cubero, Christian Trautwein
BACKGROUND & AIMS: During liver inflammation, triggering fibrogenesis and carcinogenesis immune cells play a pivotal role. In the present study we investigated the role of CCL5 in human and in murine models of chronic liver inflammation leading to HCC development. METHODS: CCL5 expression and its receptors were studied in well-defined patients with chronic liver disease (CLD) and in two murine inflammation based HCC models. The role of CCL5 in inflammation, fibrosis, tumor initiation and progression was analyzed in different cell populations of NEMO(Δhepa)/CCL5(-/-) animals and after bone marrow transplantation (BMT)...
December 20, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/28005418/wnt-signaling-in-lung-aging-and-disease
#18
Mareike Lehmann, Hoeke A Baarsma, Melanie Königshoff
Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), represent a significant and increasing health burden. Current therapies are largely symptomatic, and novel therapeutic approaches are needed. Aging has emerged as a contributing factor for the development of both IPF and COPD because their prevalence increases with age, and several pathological features of these diseases resemble classical hallmarks of aging. Aging is thought to be driven in part by aberrant activity of developmental signaling pathways that thus might drive pathological changes, a process termed antagonistic pleiotropy or developmental drift...
December 2016: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/27979231/comparative-study-on-the-freeze-stability-of-yeast-and-chemical-leavened-steamed-bread-dough
#19
Pei Wang, Runqiang Yang, Zhenxin Gu, Xueming Xu, Zhengyu Jin
The present study comparatively evaluated the evolution of yeast and chemical leavened steamed bread dough (YLD/CLD) quality during freeze/thaw (FT) cycles. The steamed bread quality of CLD was more freeze-stable than that of the YLD after 3 FT cycles. Decreased yeast viability contributed to the loss of gassing power in YLD while no significant differences were observed for CLD during FT cycles. However, faster gas release rate in frozen CLD indicated gas retention loss due to the distortion of gluten network...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27978499/coagulation-in-acutely-ill-patients-with-severe-chronic-liver-disease-insights-from-thromboelastography
#20
Patryck Lloyd-Donald, Abhinav Vasudevan, Peter Angus, Paul Gow, Johan Mårtensson, Neil Glassford, Glenn M Eastwood, Graeme K Hart, Rinaldo Bellomo
BACKGROUND AND AIMS: There is controversy about the true coagulation state of acutely ill patients with chronic liver disease (CLD) due to simultaneous pro- and anticoagulant factor deficits and limitations of conventional coagulation tests (CCTs). Thromboelastography (TEG) may provide more physiologically relevant insights. METHODS: In acutely ill patients with severe (Child-Pugh C) CLD, we conducted a prospective observational study of daily coagulation assessment with both CCTs and TEG...
November 4, 2016: Journal of Critical Care
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