Sung-Dong Park, So Yeong Cheon, Tae-Yoon Park, Bo-Young Shin, Hyunju Oh, Sankar Ghosh, Bon-Nyeo Koo, Sang-Kyou Lee
Suppression of nuclear factor-κB (NF-κB) activation, which is best known as a major regulator of innate and adaptive immune responses, is a potent strategy for the treatment of endotoxic sepsis. To inhibit NF-κB functions, we designed the intra-nuclear transducible form of transcription modulation domain (TMD) of RelA (p65), called nt-p65-TMD, which can be delivered effectively into the nucleus without influencing the cell viability, and work as interactomic inhibitors via disruption of the endogenous p65-mediated transcription complex...
August 28, 2015: Biochemical and Biophysical Research Communications