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https://www.readbyqxmd.com/read/28449232/safety-pharmacokinetics-and-pharmacologic-effects-of-the-selective-androgen-receptor-modulator-gsk2881078-in-healthy-men-and-postmenopausal-women
#1
Richard V Clark, Ann C Walker, Susan Andrews, Philip Turnbull, Jeffrey A Wald, Mindy H Magee
AIM: Selective androgen receptor modulators (SARMs) induce anabolic effects on muscle without the adverse effects of androgenic steroids. In this first-in-human study, we report safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of the SARM GSK2881078. METHODS: In Part A, healthy young men (n = 10) received a single dose of study drug (0 mg, 0.05 mg, 0.1 mg, 0.2 mg GSK2881078 or matching-placebo). In Part B, repeat-dose cohorts in men (n = 65) were 0...
April 27, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28448180/renal-denervation-decreases-blood-pressure-and-renal-tyrosine-hydroxylase-but-does-not-augment-the-effect-of-hypotensive-drugs
#2
Janusz Skrzypecki, Maciej Gawlak, Tomasz Huc, Paweł Szulczyk, Marcin Ufnal
The effect of renal denervation on the efficacy of antihypertensive drugs has not yet been elucidated. Twenty-week-old spontaneously hypertensive rats were treated with metoprolol, losartan, indapamide, or saline (controls) and assigned to renal denervation or a sham procedure. Acute hemodynamic measurements were performed ten days later. Series showing a significant interaction between renal denervation and the drugs were repeated with chronic telemetry measurements. In the saline series, denervated rats showed a significantly lower mean arterial blood pressure (blood pressure) than the sham-operated rats...
2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28446517/a-novel-%C3%AE-calcitonin-gene-related-peptide-analogue-protects-against-end-organ-damage-in-experimental-hypertension-cardiac-hypertrophy-and-heart-failure
#3
Aisah A Aubdool, Pratish Thakore, Fulye Argunhan, Sarah-Jane Smillie, Moritz Schnelle, Salil Srivastava, Khadija M Alawi, Elena Wilde, Jennifer Mitchell, Keith Farrell-Dillon, Daniel A Richards, Giuseppe Maltese, Richard C Siow, Manasi Nandi, James E Clark, Ajay M Shah, Anette Sams, Susan D Brain
Background -Research into the therapeutic potential of α-calcitonin gene-related peptide (α-CGRP) has been limited due to its peptide nature and short half-life. Here, we evaluate whether a novel potent and long lasting (t½ ≥ 7h) acylated α-CGRP analogue (αAnalogue) could alleviate and reverse cardiovascular disease in two distinct murine models of hypertension and heart failure in vivoMethods -The ability of the αAnalogue to act selectively via the CGRP pathway was shown in skin using a CGRP receptor antagonist...
April 26, 2017: Circulation
https://www.readbyqxmd.com/read/28441330/real-time-telemetry-system-for-monitoring-motion-of-ships-based-on-inertial-sensors
#4
José M Núñez, Marta G Araújo, I García-Tuñón
A telemetry system for real-time monitoring of the motions, position, speed and course of a ship at sea is presented in this work. The system, conceived as a subsystem of a radar cross-section measurement unit, could also be used in other applications as ships dynamics characterization, on-board cranes, antenna stabilizers, etc. This system was designed to be stand-alone, reliable, easy to deploy, low-cost and free of requirements related to stabilization procedures. In order to achieve such a unique combination of functionalities, we have developed a telemetry system based on redundant inertial and magnetic sensors and GPS (Global Positioning System) measurements...
April 25, 2017: Sensors
https://www.readbyqxmd.com/read/28434968/cardiac-contractility-correction-strategies-applied-to-telemetry-data-from-a-hesi-sponsored-consortium
#5
Emmanuel Boulay, Michael K Pugsley, Vincent Jacquemet, Alain Vinet, Michael V Accardi, Maxim Soloviev, Eric Troncy, Jennifer M Doyle, Jennifer Beck Pierson, Simon Authier
INTRODUCTION: QT has a long history of heart rate (HR) correction but limited investigations have been undertaken to assess the impact of cardiovascular parameters on left ventricular (LV) contractility in drug safety testing. Cardiac contractility is affected by preload (Cyon-Frank-Starling law), afterload (Anrep effect) and HR (Bowditch effect). We evaluated multi-parameter correction methods to help with dP/dtmax interpretation. METHODOLOGY: Modeling was undertaken using data from dogs in single or double 4×4 Latin square studies...
April 20, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28432961/diurnal-patterns-and-relationships-between-physiological-and-self-reported-stress-in-patients-with-epilepsy-and-psychogenic-non-epileptic-seizures
#6
Barbora Novakova, Peter R Harris, Markus Reuber
PURPOSE: Patients with epilepsy and those with psychogenic non-epileptic seizures (PNES) experience high levels of stress and stress is one of the most frequently self-identified seizure precipitants. Although stress is a multifaceted phenomenon, few studies have systematically examined its different components in patients with seizures. The aim of this study was therefore to describe diurnal patterns of psychological and physiological measures of stress in patients with epilepsy and patients with PNES, and explore their relationships to each other in order to improve our understanding of the mechanisms underlying stress and seizure occurrence in these patients...
April 19, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28432853/an-evidence-based-approach-to-reducing-cardiac-telemetry-alarm-fatigue
#7
Ekta Srinivasa, Jaspreet Mankoo, Charles Kerr
BACKGROUND: It is estimated that between 80% and 99% of alarms in the clinical areas are in actionable alarms (Gross, Dahl, & Nielson). Alarm management is one of the Joint Commission's National Patient Safety Goals (2014) because sentinel events have directly been linked to the devices generating these alarms. PURPOSE: At an acute care facility in Boston, a multidisciplinary team consisting of Nursing, Biomedical Engineers, Patient Safety and Providers was formed to conduct a pilot study on the state of telemetry alarms on a surgical floor...
April 22, 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28429311/improving-animal-welfare-using-continuous-nalbuphine-infusion-in-a-long-term-rat-model-of-sepsis
#8
Victor Jeger, Mattia Arrigo, Florian F Hildenbrand, Daniel Müller, Paulin Jirkof, Till Hauffe, Burkhardt Seifert, Margarete Arras, Donat R Spahn, Dominique Bettex, Alain Rudiger
BACKGROUND: Sepsis research relies on animal models to investigate the mechanisms of the dysregulated host response to infection. Animal welfare concerns request the use of potent analgesics for the Refinement of existing sepsis models, according to the 3Rs principle. Nevertheless, adequate analgesia is often missing, partly because the effects of analgesics in this particular condition are unknown. We evaluated the use of nalbuphine, an opioid with kappa agonistic and mu antagonistic effects, in rats with and without experimental sepsis...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28429262/movement-of-a-female-polar-bear-ursus-maritimus-in-the-kara-sea-during-the-summer-sea-ice-break-up
#9
V V Rozhnov, N G Platonov, S V Naidenko, I N Mordvintsev, E A Ivanov
The polar bear movement trajectory in relation to onset date of the sea-ice break-up was studied in the coastal zone of the Taimyr Peninsula, eastern part of the Kara Sea, using as an example a female polar bear tagged by a radio collar with an Argos satellite transmitter. Analysis of the long-term pattern of ice melting and tracking, by means of satellite telemetry, of the female polar bear who followed the ice-edge outgoing in the north-eastern direction (in summer 2012) suggests that direction of the polar bear movement depends precisely on the direction of the sea-ice cover break-up...
January 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28428757/circadian-rhythm-in-kidney-tissue-oxygenation-in-the-rat
#10
Tonja W Emans, Ben J Janssen, Jaap A Joles, C T Paul Krediet
Blood pressure, renal hemodynamics, electrolyte, and water excretion all display diurnal oscillation. Disturbance of these patterns is associated with hypertension and chronic kidney disease. Kidney oxygenation is dependent on oxygen delivery and consumption that in turn are determined by renal hemodynamics and metabolism. We hypothesized that kidney oxygenation also demonstrates 24-h periodicity. Telemetric oxygen-sensitive carbon paste electrodes were implanted in Sprague-Dawley rats (250-300 g), either in renal medulla (n = 9) or cortex (n = 7)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28425172/the-homeostatic-and-circadian-sleep-recovery-responses-after-total-sleep-deprivation-in-mice
#11
Garance Dispersyn, Fabien Sauvet, Danielle Gomez-Merino, Sylvain Ciret, Catherine Drogou, Damien Leger, Thierry Gallopin, Mounir Chennaoui
Many studies on sleep deprivation effects lack data regarding the recovery period. We investigated the 2-day homeostatic and circadian sleep recovery response to 24 h of total sleep deprivation (TSD) induced by brief rotation of an activity wheel. Eight mice were implanted with telemetry transmitters (DSI F40-EET) that recorded simultaneously their electroencephalography (EEG), locomotor activity and temperature during 24 h of baseline (BSL), TSD and 2 days of recovery (D1 and D2). In a second experiment, two groups of five non-implanted mice underwent TSD or ad libitum sleep, after which they were killed, adrenal glands were weighed and blood was collected for analysis of corticosterone concentration...
April 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28416413/evaluation-of-the-physiotel%C3%A2-digital-m11-cardiovascular-telemetry-implant-in-socially-housed-cynomolgus-monkeys-up-to-16weeks-after-surgery
#12
Ninette K Andersen, Olivier Meyer, Alys Bradley, Nils Dragsted, Anders B Lassen, Ingrid Sjögren, Julie M Larsen, Warren Harvey, Rastislav Bator, Aileen Milne
INTRODUCTION: The novel PhysioTel™ Digital M11 telemetry implant was evaluated in socially housed monkeys with respect to both safety pharmacological cardiovascular (arterial blood pressure (BP), heart rate (HR) and electrocardiogram (ECG)) and toxicological (clinical pathology and histopathology) endpoints. METHODS: Telemetry and clinical pathology data were obtained repeatedly up to 16weeks after surgery in four female cynomolgus monkeys, followed by necropsy...
April 14, 2017: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/28405358/integrating-multiple-technologies-to-understand-the-foraging-behaviour-of-hawaiian-monk-seals
#13
Kenady Wilson, Charles Littnan, Patrick Halpin, Andrew Read
The objective of this research was to investigate and describe the foraging behaviour of monk seals in the main Hawaiian Islands. Specifically, our goal was to identify a metric to classify foraging behaviour from telemetry instruments. We deployed accelerometers, seal-mounted cameras and GPS tags on six monk seals during 2012-2014 on the islands of Molokai, Kauai and Oahu. We used pitch, calculated from the accelerometer, to identify search events and thus classify foraging dives. A search event and consequent 'foraging dive' occurred when the pitch was greater than or equal to 70° at a depth less than or equal to -3 m...
March 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28405298/seasonal-and-temperature-related-movement-of-colorado-river-cutthroat-trout-in-a-low-elevation-rocky-mountain-stream
#14
Brian W Hodge, Kyle D Battige, Kevin B Rogers
Mobile species will migrate considerable distances to find habitats suitable for meeting life history requirements, and stream-dwelling salmonids are no exception. In April-October 2014, we used radio-telemetry to examine habitat use and movement of 36 Colorado River cutthroat trout Oncorhynchus clarkii pleuriticus (CRCT) in a 14.9-km fragment of Milk Creek, a relatively low-elevation stream in the Rocky Mountains (Colorado). We also used a network of data loggers to track stream temperature across time and space...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28405284/role-of-breeding-and-natal-movements-in-lifetime-dispersal-of-a-forest-dwelling-rodent
#15
Vesa Selonen, Ralf Wistbacka
The lifetime movements of an individual determine the gene flow and invasion potential of the species. However, sex dependence of dispersal and selective pressures driving dispersal have gained much more attention than dispersal at different life and age stages. Natal dispersal is more common than dispersal between breeding attempts, but breeding dispersal may be promoted by resource availability and competition. Here, we utilize mark-recapture data on the nest-box population of Siberian flying squirrels to analyze lifetime dispersal patterns...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28405277/a-hidden-markov-movement-model-for-rapidly-identifying-behavioral-states-from-animal-tracks
#16
Kim Whoriskey, Marie Auger-Méthé, Christoffer M Albertsen, Frederick G Whoriskey, Thomas R Binder, Charles C Krueger, Joanna Mills Flemming
Electronic telemetry is frequently used to document animal movement through time. Methods that can identify underlying behaviors driving specific movement patterns can help us understand how and why animals use available space, thereby aiding conservation and management efforts. For aquatic animal tracking data with significant measurement error, a Bayesian state-space model called the first-Difference Correlated Random Walk with Switching (DCRWS) has often been used for this purpose. However, for aquatic animals, highly accurate tracking data are now becoming more common...
April 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28404615/myeloperoxidase-mediates-postischemic-arrhythmogenic-ventricular-remodeling
#17
Martin Mollenhauer, Kai Friedrichs, Max Lange, Jan Gesenberg, Lisa Remane, Christina Kerkenpaß, Jenny Krause, Johanna Schneider, Thorben Ravekes, Martina Maass, Marcel Halbach, Gabriel Peinkofer, Tomo Saric, Dennis Mehrkens, Matti Adam, Florian G Deuschl, Denise Lau, Birgit Geertz, Kashish Manchanda, Thomas Eschenhagen, Lukas Kubala, Tanja K Rudolph, Yuping Wu, Wh W Tang, Stanley L Hazen, Stephan Baldus, Anna Klinke, Volker Rudolph
Rationale: Ventricular arrhythmias remain the leading cause of death in patients suffering myocardial ischemia. Myeloperoxidase (MPO), a heme-enzyme released by polymorphonuclear neutrophils, accumulates within ischemic myocardium and has been linked to adverse left ventricular remodeling. Objective: To reveal the role of MPO for the development of ventricular arrhythmias. Methods and Results: In different murine models of myocardial ischemia MPO deficiency profoundly decreased vulnerability for ventricular tachycardia (VT) upon programmed right ventricular and burst stimulation and spontaneously as assessed by ECG telemetry following isoproterenol injection...
April 12, 2017: Circulation Research
https://www.readbyqxmd.com/read/28402340/windscapes-and-olfactory-foraging-in-a-large-carnivore
#18
Ron R Togunov, Andrew E Derocher, Nicholas J Lunn
The theoretical optimal olfactory search strategy is to move cross-wind. Empirical evidence supporting wind-associated directionality among carnivores, however, is sparse. We examined satellite-linked telemetry movement data of adult female polar bears (Ursus maritimus) from Hudson Bay, Canada, in relation to modelled winds, in an effort to understand olfactory search for prey. In our results, the predicted cross-wind movement occurred most frequently at night during winter, the time when most hunting occurs, while downwind movement dominated during fast winds, which impede olfaction...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401682/guideline-based-intervention-to-reduce-telemetry-rates-in-a-large-tertiary-centre
#19
Satish Ramkumar, Edward H Tsoi, Ajay Raghunath, Floyd F Dias, Christopher Li Wai Suen, Andrew H Tsoi, Darren R Mansfield
BACKGROUND: Inappropriate cardiac telemetry use is associated with reduced patient flow and increased health care costs. AIM: To evaluate the outcomes of guideline-based application of cardiac telemetry. METHODS: Phase I involved a prospective audit(03-09/2011) of telemetry use at a tertiary hospital. Data was collected on indication for telemetry and clinical outcomes. Phase II prospectively included patients > 18yrs under general medicine requiring ward based telemetry...
April 12, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28394922/correction-evolution-of-impedance-field-telemetry-after-one-day-of-activation-in-cochlear-implant-recipients
#20
Hao-Chun Hu, Joshua Kuang-Chao Chen, Chia-Mi Tsai, Hsing-Yi Chen, Tao-Hsin Tung, Lieber Po-Hung Li
[This corrects the article DOI: 10.1371/journal.pone.0173367.].
2017: PloS One
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