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https://www.readbyqxmd.com/read/28718004/impact-of-gastrointestinal-events-on-patient-reported-outcomes-in-asia-pacific-women-with-osteoporosis-baseline-results-of-the-music-os-ap-study
#1
A Modi, P R Ebeling, M S Lee, Y K Min, A Mithal, X Yang, S Baidya, S Sen, S Sajjan
The purpose of this study was to describe the impact of gastrointestinal events on patient-reported outcomes and health care resource use among Asia-Pacific women with postmenopausal osteoporosis. The results of this study show that gastrointestinal events decreased adherence, treatment satisfaction, and quality of life in Asia-Pacific women with postmenopausal osteoporosis. PURPOSE: This study aimed to describe the impact of gastrointestinal (GI) events on patient-reported outcomes and health care resource use among Asia-Pacific women with postmenopausal osteoporosis...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28716226/cytokines-do-play-a-role-in-pathogenesis-of-tuberculous-meningitis-a-prospective-study-from-a-tertiary-care-center-in-india
#2
S Sharma, M K Goyal, K Sharma, M Modi, M Sharma, N Khandelwal, S Prabhakar, N Sharma, Shree R, J Gairolla, A Jain, V Lal
BACKGROUND: Though animal studies have suggested a role for proinflammatory cytokines in pathogenesis their exact role in pathogenesis of human meningeal tuberculosis continues to be controversial with different studies yielding contradictory results. AIM AND OBJECTIVES: To study the levels of proinflammatory cytokines in serum and cerebrospinal fluid (CSF) of patients with tubercular meningitis (TBM) and to determine whether these correlate with disease severity...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28712519/contemporary-outcomes-of-infants-with-gastroschisis-in-north-america-a-multicenter-cohort-study
#3
Brenna S Fullerton, Cristine S Velazco, Eric A Sparks, Kate A Morrow, Erika M Edwards, Roger F Soll, Biren P Modi, Jeffrey D Horbar, Tom Jaksic
OBJECTIVE: To quantify outcomes and analyze factors predictive of morbidity and mortality in infants with gastroschisis. STUDY DESIGN: Clinical data regarding neonates with gastroschisis born between 2009 and 2014 were prospectively collected at 175 North American centers. Multivariate regression was used to assess risk factors for mortality and length of stay (LOS). RESULTS: Gastroschisis was diagnosed in 4420 neonates with median birth weight 2410 g (IQR 2105-2747)...
July 13, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28707109/the-assessment-of-cough-in-a-sarcoidosis-clinic-using-a-validated-instrument-and-a-visual-analog-scale
#4
Marc A Judson, Amit Chopra, Edward Conuel, Efstratios Koutroumpakis, Christopher Schafer, Adam Austin, Robert Zhang, Kerry Cao, Rani Berry, Malik M H S Khan, Aakash Modi, Ritu Modi, Stephanie Jou, Furqan Ilyas, Recai M Yucel
PURPOSE: Cough is a common symptom of pulmonary sarcoidosis. We analyzed the severity of cough and factors associated with cough in a university sarcoidosis clinic cohort. METHODS: Consecutive patients completed the Leicester Cough Questionnaire (LCQ) and a cough visual analog scale (VAS). Clinical and demographic data were collected. Means of the LCQ were analyzed in patients who had multiple visits in terms of constant variables (e.g., race, sex). RESULTS: 355 patients completed the LCQ and VAS at 874 visits...
July 13, 2017: Lung
https://www.readbyqxmd.com/read/28704920/a-synergy-cropland-of-china-by-fusing-multiple-existing-maps-and-statistics
#5
Miao Lu, Wenbin Wu, Liangzhi You, Di Chen, Li Zhang, Peng Yang, Huajun Tang
Accurate information on cropland extent is critical for scientific research and resource management. Several cropland products from remotely sensed datasets are available. Nevertheless, significant inconsistency exists among these products and the cropland areas estimated from these products differ considerably from statistics. In this study, we propose a hierarchical optimization synergy approach (HOSA) to develop a hybrid cropland map of China, circa 2010, by fusing five existing cropland products, i.e., GlobeLand30, Climate Change Initiative Land Cover (CCI-LC), GlobCover 2009, MODIS Collection 5 (MODIS C5), and MODIS Cropland, and sub-national statistics of cropland area...
July 12, 2017: Sensors
https://www.readbyqxmd.com/read/28695843/magnetic-impurity-doping-induced-spin-glass-state-and-short-range-zigzag-order-in-the-honeycomb-iridate-na-sub-2-sub-iro-sub-3-sub
#6
Wanping Cai, Zhengren Yan, Rumei Liu, Minghui Qin, Min Zeng, Xubing Lu, Xingsen Gao, Junming Liu
Based on the modied Heisenberg-Kitaev model, the eects of magnetic substitution on the magnetic properties of the honeycomb-lattice iridate Na2IrO3 are studied using Monte Carlo simulations. It is observed that the long-range zigzag state of the original system is rather fragile and can be replaced by a spin-glass state even for small substitution, well consistent with the experimental observation in Ru-substituted samples [Mehlawat, Sharma, and Singh, Phys. Rev. B 92, 134412 (2015)]...
July 11, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28693658/patient-hand-colonization-with-mdros-is-associated-with-environmental-contamination-in-post-acute-care
#7
Payal K Patel, Julia Mantey, Lona Mody
We assessed multidrug-resistant organism (MDRO) patient hand colonization in relation to the environment in post-acute care to determine risk factors for MDRO hand colonization. Patient hand colonization was significantly associated with environmental contamination. Risk factors for hand colonization included disability, urinary catheter, recent antibiotic use, and prolonged hospital stay. Infect Control Hosp Epidemiol 2017:1-4.
July 11, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28692415/whole-genome-sequencing-of-mycobacterium-tuberculosis-isolates-from-extrapulmonary-sites
#8
Kusum Sharma, Renu Verma, Jayshree Advani, Oishi Chatterjee, Hitendra S Solanki, Aman Sharma, Subhash Varma, Manish Modi, Pallab Ray, Kanchan K Mukherjee, Megha Sharma, Mandeed Singh Dhillion, Mrutyunjay Suar, Aditi Chatterjee, Akhilesh Pandey, Thottethodi Subrahmanya Keshava Prasad, Harsha Gowda
Tuberculosis (TB) remains one of the leading causes of morbidity and mortality worldwide. Extrapulmonary tuberculosis (EPTB) constitutes around 15-20% of TB cases in immunocompetent individuals. Extrapulmonary sites that are affected by TB include bones, lymph nodes, meningitis, pleura, and genitourinary tract. Whole genome sequencing has emerged as a powerful tool to map genetic diversity among Mycobacterium tuberculosis (MTB) isolates and identify the genomic signatures associated with drug resistance, pathogenesis, and disease transmission...
July 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28691587/improvement-of-amoxicillin-removal-from-aqueous-environment-by-applying-functionalized-carbon-nanotube
#9
M Bazregari, N Farhadian
Multiwalled carbon nanotubes (MWCNTs) were applied for amoxicillin removal from aqueous environment. To enhance the adsorption capacity of adsorbent, MWCNT with modified surface was applied. A functional group as 8-hydroxyquinoline (8-HQ) and carboxyl group were selected to modify the surface of MWCNT. Fourier transform infrared spectroscopy and scanning electron microscopy confirmed the successful surface modification of MWCNTs. Some important parameters associated with the adsorption capacity such as pH, initial concentration of amoxicillin and equilibrium time of adsorption were investigated for pristine and functionalized MWCNTs...
July 10, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28688254/monitoring-ice-variations-in-qinghai-lake-from-1979-to-2016-using-passive-microwave-remote-sensing-data
#10
Yu Cai, Chang-Qing Ke, Zheng Duan
Lake ice is a sensitive indicator of climate change. Based on the disparities between the brightness temperatures of lake ice and water, passive microwave data can be used to monitor the ice variations of a lake. With focus on the analysis of long time series variability of lake ice, this study extracts four characteristic dates related to lake ice (the annual freeze start, freeze completion, ablation start and ablation completion dates) for Qinghai Lake from 1979 to 2016 using Scanning Multichannel Microwave Radiometer (SMMR) and Special Sensor Microwave Imager (SSM/I) passive microwave brightness temperature data...
July 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28683980/midterm-survivorship-and-complications-of-total-knee-arthroplasty-in-patients-with-dwarfism
#11
Timothy L Tan, Michael M Kheir, Ronuk Modi, Chi-Lung Chen, Hongyi Shao, Antonia F Chen
BACKGROUND: Dwarfism is associated with skeletal dysplasias and joint deformities that frequently result in osteoarthritis requiring treatment with total knee arthroplasty (TKA). These surgeries can be challenging because of alignment deformities, poor bone stock, and smaller components. This study aims to compare TKA implant survivorship and complications between dwarf and nondwarf patients. METHODS: A retrospective case-control study was performed from 1997-2014 evaluating 115 TKAs in patients under the height threshold of 147...
June 9, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28680642/long-lasting-response-to-oral-therapy-in-a-young-male-with-monogenic-diabetes-as-part-of-hnf1b-related-disease
#12
Elena Carrillo, Amparo Lomas, Pedro J Pinés, Cristina Lamas
Mutations in hepatocyte nuclear factor 1β gene (HNF1B) are responsible for a multisystemic syndrome where monogenic diabetes (classically known as MODY 5) and renal anomalies, mostly cysts, are the most characteristic findings. Urogenital malformations, altered liver function tests, hypomagnesemia or hyperuricemia and gout are also part of the syndrome. Diabetes in these patients usually requires early insulinization. We present the case of a young non-obese male patient with a personal history of renal multicystic dysplasia and a debut of diabetes during adolescence with simple hyperglycemia, negative pancreatic autoimmunity and detectable C-peptide levels...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28680076/size-dependent-validation-of-modis-mcd64a1-burned-area-over-six-vegetation-types-in-boreal-eurasia-large-underestimation-in-croplands
#13
Chunmao Zhu, Hideki Kobayashi, Yugo Kanaya, Masahiko Saito
Pollutants emitted from wildfires in boreal Eurasia can be transported to the Arctic, and their subsequent deposition could accelerate global warming. The Moderate Resolution Imaging Spectroradiometer (MODIS) MCD64A1 burned area product is the basis of fire emission products. However, uncertainties due to the "moderate resolution" (500 m) characteristic of the MODIS sensor could be introduced. Here, we present a size-dependent validation of MCD64A1 with reference to higher resolution (better than 30 m) satellite products (Landsat 7 ETM+, RapidEye, WorldView-2, and GeoEye-1) for six ecotypes over 12 regions of boreal Eurasia...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28675882/characterizing-spatiotemporal-dynamics-in-phenology-of-urban-ecosystems-based-on-landsat-data
#14
Xuecao Li, Yuyu Zhou, Ghassem R Asrar, Lin Meng
Seasonal phenology of vegetation plays an important role in global carbon cycle and ecosystem productivity. In urban environments, vegetation phenology is also important because of its influence on public health (e.g., allergies), and energy demand (e.g. cooling effects). In this study, we studied the potential use of remotely sensed observations (i.e. Landsat data) to derive some phenology indicators for vegetation embedded within the urban core domains in four distinctly different U.S. regions (Washington, D...
July 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28675691/pd-1-inhibition-in-congenital-pigment-synthesizing-metastatic-melanoma
#15
Angela C Weyand, Rajen J Mody, Raja M Rabah, Valerie P Opipari
A newborn female child was born with a congenital pigment synthesizing melanoma of the scalp. Further workup revealed metastatic disease within the liver, lungs, and left tibia. Whole exome sequencing was performed on multiple samples that revealed one somatic mutation, lysine methyltransferase 2C (KMT2C), at low allelic frequency but no v-Raf murine sarcoma viral oncogene homolog B (BRAF), NF-1 mutation. Programmed death ligand 1 was moderately expressed. Treatment was initiated with the programmed cell death protein 1 inhibitor nivolumab...
July 4, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28674917/fire-distribution-in-peninsular-malaysia-sumatra-and-borneo-in-2015-with-special-emphasis-on-peatland-fires
#16
Jukka Miettinen, Chenghua Shi, Soo Chin Liew
In this paper, we analyze the spatio-temporal distribution of vegetation fires in Peninsular Malaysia, Sumatra, and Borneo in the severe El Niño year of 2015, concentrating on the distribution of fires between mineral soils and peatland areas, and between land cover types in peatland areas. The results reveal that 53% of all Moderate Resolution Imaging Spectroradiometer (MODIS) fire detections were recorded in peatlands that cover only 12% of the study area. However, fire occurrence in the peatland areas was highly dependent on land cover type...
July 3, 2017: Environmental Management
https://www.readbyqxmd.com/read/28664882/structural-variation-in-a-synchrotron-induced-contamination-layer-a-c-h-deposited-on-a-toroidal-au-mirror-surface
#17
P K Yadav, R K Gupta, M K Swami, M H Modi
A carbon layer deposited on an optical component is the result of complex interactions between the optical surface, adsorbed hydrocarbons, photons and secondary electrons (photoelectrons generated on the surface of optical elements). In the present study a synchrotron-induced contamination layer on a 340 mm × 60 mm Au-coated toroidal mirror has been characterized. The contamination layer showed a strong variation in structural properties from the centre of the mirror to the edge region (along the long dimension of the mirror) due to the Gaussian distribution of the incident photon beam intensity/power on the mirror surface...
July 1, 2017: Journal of Synchrotron Radiation
https://www.readbyqxmd.com/read/28664602/neurod1-deficient-diabetes-mody6-identification-of-the-first-cases-in-japanese-and-the-clinical-features
#18
Yukio Horikawa, Mayumi Enya, Hiroyo Mabe, Megumi Fukushima, Noriyuki Takubo, Masaaki Ohashi, Fuki Ikeda, Ken-Ichi Hashimoto, Hirotaka Watada, Jun Takeda
AIMS: Only a few families with neuronal differentiation 1 (NEUROD1)-deficient diabetes, currently designated as maturity-onset diabetes of the young 6 (MODY6), have been reported, but mostly in Caucasian, and no mutation has been identified by family-based screening in Japanese. Accordingly, the phenotypic details of the disease remain to be elucidated. METHODS: We examined a total of 275 subjects having diabetes suspected to be MODY who were negative for mutations in MODY1-5 referred from 155 medical institutions throughout Japan...
June 30, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28663157/phenotype-heterogeneity-in-glucokinase-maturity-onset-diabetes-of-the-young-gck-mody-patients-single-pediatric-centre-observation
#19
Anna Wedrychyowicz, Ewa Tobor, Magdalena Wilk, Ewa Ziolkowska-Ledwith, Anna Rams, Katarzyna Wzorek, Barbara Sabal, Małgorzata Stelmach, Jerzy B Starzyk
OBJECTIVE: The aim of the study was to evaluate the clinical phenotypes of Glucokinase - Maturity Onset Diabetes of the Young (GCK-MODY) pediatric patients from South-West Poland and to search for phenotype-genotype correlations. METHODS: We performed retrospective analysis of data of all 37 CGK-MODY patients, 21 girls, age 1.9-20.1, mean 12.5±5.2 years, treated in our centre. A retrospective analysis of clinical data from years 2002-2013 was performed. RESULTS: GCK-MODY carriers were found among 1043 diabetes mellitus (DM) patients (3%), they were second the most numerous groups of DM patients, following type 1 DM, in our centre...
June 30, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28660171/the-feasibility-and-safety-of-surgery-in-patients-receiving-immune-checkpoint-inhibitors-a-retrospective-study
#20
Alexandra W Elias, Pashtoon M Kasi, John A Stauffer, David D Thiel, Dorin T Colibaseanu, Kabir Mody, Richard W Joseph, Sanjay P Bagaria
Immune checkpoint inhibitors (ICI) are revolutionizing care for cancer patients. The list of malignancies for which the Food and Drug Administration is granting approval is rapidly increasing. Furthermore, there is a concomitant increase in clinical trials incorporating ICI. However, the safety of ICI in patients undergoing surgery remains unclear. Herein, we assessed the safety of ICI in the perioperative setting at a single center. We conducted a retrospective review of patients who underwent planned surgery while receiving ICI in the perioperative setting from 2012 to 2016...
2017: Frontiers in Oncology
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