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https://www.readbyqxmd.com/read/28087722/a-systematic-review-of-administrative-and-clinical-databases-of-infants-admitted-to-neonatal-units
#1
Yevgeniy Statnikov, Buthaina Ibrahim, Neena Modi
OBJECTIVES: High quality information, increasingly captured in clinical databases, is a useful resource for evaluating and improving newborn care. We conducted a systematic review to identify neonatal databases, and define their characteristics. METHODS: We followed a preregistered protocol using MesH terms to search MEDLINE, EMBASE, CINAHL, Web of Science and OVID Maternity and Infant Care Databases for articles identifying patient level databases covering more than one neonatal unit...
January 13, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28087302/the-long-term-effect-of-bacille-calmette-gu%C3%A3-rin-vaccination-on-tuberculin-skin-testing-a-55-year-follow-up-study
#2
James D Mancuso, Rupal M Mody, Cara H Olsen, Lee H Harrison, Mathuram Santosham, Naomi E Aronson
BACKGROUND: Bacille Calmette-Guérin vaccination (BCG) is known to cause false positive tuberculin skin test (TST) results from cross-reactions to mycobacterial antigens. However, the duration of BCG influence on the TST is poorly characterized. The objective of the study was to assess the long-term effect of BCG vaccination on TST reactivity. METHODS: Data on TST reactivity were prospectively collected during 1935-47 as part of a clinical trial among American Indians / Alaskan Natives and retrospectively thereafter between 1948 and 1998...
January 10, 2017: Chest
https://www.readbyqxmd.com/read/28087269/mitochondrial-roles-of-the-psychiatric-disease-risk-factor-disc1
#3
REVIEW
R Norkett, S Modi, J T Kittler
Ion transport during neuronal signalling utilizes the majority of the brain's energy supply. Mitochondria are key sites for energy provision through ATP synthesis and play other important roles including calcium buffering. Thus, tightly regulated distribution and function of these organelles throughout the intricate architecture of the neuron is essential for normal synaptic communication. Therefore, delineating mechanisms coordinating mitochondrial transport and function is essential for understanding nervous system physiology and pathology...
January 10, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28079690/noncontact-evaluation-of-corneal-grafts-swept-source-fourier-domain-oct-versus-high-resolution-scheimpflug-imaging
#4
Eszter Szalai, Gábor Németh, Ziad Hassan, László Módis
PURPOSE: To study the reliability and repeatability of anterior segment measurements in patients who underwent penetrating keratoplasty with swept light source Fourier domain anterior segment optical coherence tomography (SS-OCT) in comparison with a high-resolution Scheimpflug camera. METHODS: Keratometry (K) and elevation data of the anterior and posterior corneal surfaces, central corneal thickness, and anterior chamber depth were determined in 56 postkeratoplasty eyes (mean age: 59...
January 11, 2017: Cornea
https://www.readbyqxmd.com/read/28075598/organocatalytic-regioselective-concomitant-thiocyanation-and-acylation-of-oxiranes-using-aroyl-isothiocyanates
#5
Anju Modi, Wajid Ali, Bhisma K Patel
A regioselective and concomitant transfer of thiocyanate (-SCN) and aroyl/acyl (-COR) groups from aroyl/acyl isothiocyanates onto oxiranes was achieved, giving thiocyanato benzoates in 100% atom economy. In this biomimetic organocatalytic process, one part (-SCN) of aroyl/acyl isothiocyanates acts as the nucleophile whereas the other half (-COR) serves as an electrophilic partner.
January 11, 2017: Organic Letters
https://www.readbyqxmd.com/read/28074871/long-term-modis-observations-of-cyanobacterial-dynamics-in-lake-taihu-responses-to-nutrient-enrichment-and-meteorological-factors
#6
Kun Shi, Yunlin Zhang, Yongqiang Zhou, Xiaohan Liu, Guangwei Zhu, Boqiang Qin, Guang Gao
We developed and validated an empirical model for estimating chlorophyll a concentrations (Chla) in Lake Taihu to generate a long-term Chla and algal bloom area time series from MODIS-Aqua observations for 2003 to 2013. Then, based on the long-term time series data, we quantified the responses of cyanobacterial dynamics to nutrient enrichment and climatic conditions. Chla showed substantial spatial and temporal variability. In addition, the annual mean cyanobacterial surface bloom area exhibited an increasing trend across the entire lake from 2003 to 2013, with the exception of 2006 and 2007...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28073919/trub1-is-the-predominant-pseudouridine-synthase-acting-on-mammalian-mrna-via-a-predictable-and-conserved-code
#7
Modi Safra, Ronit Nir, Daneyal Farouq, Schraga Schwartz
Following synthesis, RNA can be modified with over 100 chemically distinct modifications, which can potentially regulate RNA expression post-transcriptionally. Pseudouridine (Ψ) was recently established to be widespread and dynamically regulated on yeast mRNA, but less is known about Ψ presence, regulation and biogenesis in mammalian mRNA. Here, we sought to characterize the Ψ landscape on mammalian mRNA, to identify the main Ψ-synthases (PUSs) catalyzing Ψ formation, and to understand the factors governing their specificity towards selected targets...
January 10, 2017: Genome Research
https://www.readbyqxmd.com/read/28073539/physical-processes-leading-to-the-development-of-an-anomalously-large-cochlodinium-polykrikoides-bloom-in-the-east-sea-japan-sea
#8
Dae-Won Kim, Young-Heon Jo, Jong-Kuk Choi, Jang-Geun Choi, Hongsheng Bi
An anomalously large Harmful Algal Bloom (HAB) was observed in the southwest coast of the East/Japan Sea (hereafter the East Sea) during the summer of 2013. During this time period, the presence of Cochlodinium polykrikoides (C. polykrikoides) was detected by the Geostationary Ocean Color Imager (GOCI) and validated by in-situ observations. GOCI observations have been available since 2011, thus allowingto examine various stages of the physical condition of the developing C. polykrikoides bloom, thereby other multi-satellite and buoy measurements obtained between 2011 and 2013...
May 2016: Harmful Algae
https://www.readbyqxmd.com/read/28073456/long-term-trend-of-ulva-prolifera-blooms-in-the-western-yellow-sea
#9
Lin Qi, Chuanmin Hu, Qianguo Xing, Shaoling Shang
Blooms of the green macroalga Ulva prolifera in the western Yellow Sea occurred every year since 2008, and they have been reported and studied extensively using a variety of means including remote sensing. However, to date, long-term bloom patterns have not been reported except for a few case studies showing examples in different years. Here, using MODIS observations and an objective method to perform statistical analysis, mean Ulva coverage in the western Yellow Sea has been derived and analyzed between 2007 and 2015 at both monthly and annual scales...
September 2016: Harmful Algae
https://www.readbyqxmd.com/read/28072857/quantification-of-local-warming-trend-a-remote-sensing-based-approach
#10
Khan Rubayet Rahaman, Quazi K Hassan
Understanding the warming trends at local level is critical; and, the development of relevant adaptation and mitigation policies at those levels are quite challenging. Here, our overall goal was to generate local warming trend map at 1 km spatial resolution by using: (i) Moderate Resolution Imaging Spectroradiometer (MODIS)-based 8-day composite surface temperature data; (ii) weather station-based yearly average air temperature data; and (iii) air temperature normal (i.e., 30 year average) data over the Canadian province of Alberta during the period 1961-2010...
2017: PloS One
https://www.readbyqxmd.com/read/28068691/a-dual-modality-approach-of-endobiliary-radiofrequency-ablation-and-self-expandable-metal-stent-placement-to-control-malignant-hemobilia
#11
Christopher M Linz, Rohan M Modi, Somashekar G Krishna
No abstract text is available yet for this article.
February 2017: Endoscopy
https://www.readbyqxmd.com/read/28068083/simultaneous-electrochemical-detection-of-benzimidazole-fungicides-carbendazim-and-thiabendazole-using-a-novel-nano-hybrid-material-modi%C3%AF-ed-electrode
#12
Yuanyuan Dong, Lijun Yang, Lei Zhang
In this work, a novel ZnFe2O4/SWCNTs nano-hybrid was successfully synthesized as electrode materials and applied to the simultaneous quantitative determination of carbendazim (CBZ) and thiabendazole (TBZ). The electrochemical behaviors of CBZ and TBZ on the ZnFe2O4/SWCNTs/GCE were investigated using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). The electrochemical active area of modified electrode was calculated, which is nearly 5.5 times that of the bare electrode. The influence of various factors such as accumulation time, pH and scan rates, type of surfactant, and the electrochemical reaction mechanism were studied...
January 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28062260/effect-of-differential-surface-anisotropy-on-performance-of-two-plate-shaped-crystals-of-aspirin-form-i
#13
Tanshu Jain, Sneha Sheokand, Sameer R Modi, Bharat Ugale, Ram Naresh Yadav, Navin Kumar, C M Nagaraja, Arvind K Bansal
Differential surface anisotropy of different crystals of the same API can have a significant impact on their pharmaceutical performance. The present work investigated the impact of differential surface anisotropy of two plate-shaped crystals of aspirin (form I) on their hygroscopicity, stability and compaction behavior. These crystals differed in their predominant facets (100) and (001) and were coded as AE-100 & E-001. (100) facets exposed polar carbonyl groups which provided hydrophilicity to the facets. In contrast, (001) facets possessed hydrophobicity as they exposed non-polar aryl and methyl groups...
January 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28061948/levels-of-microrna-mir-16-and-mir-155-are-altered-in-serum-of-patients-with-tuberculosis-and-associate-with-responses-to-therapy
#14
Vishal Wagh, Anant Urhekar, Deepak Modi
Identification of blood biomarkers that can be useful for predicting Mycobacterium tuberculosis (M.TB) infection, effect of therapy and Multi Drug Resistant (MDR) TB infected individuals is clinically useful for combating tuberculosis epidemic. In this study, we have evaluated the levels of selected miRNAs in serum of TB and MDR TB patients. In addition, we have studied their levels in serum of patients post-therapy. The levels of 4-miRNAs (miR-16, miR-29a, miR-125b and miR-155) were measured in 30 newly diagnosed TB patients, 19 Multi Drug Resistant (MDR) TB patients, 10 patients who completed TB therapy and were TB negative...
January 2017: Tuberculosis
https://www.readbyqxmd.com/read/28058444/frequency-of-discontinuation-of-injectable-osteoporosis-therapies-in-us-patients-over-2%C3%A2-years
#15
A Modi, S Sajjan, R Insinga, J Weaver, E M Lewiecki, S T Harris
: Little is known about treatment patterns with injectable osteoporosis therapies. At 12 months, the probability of discontinuation was 69.1% among patients using ibandronate, followed by teriparatide (67.1%), zoledronic acid (59.2%), and denosumab (48.8%). By 24 months, discontinuation was higher for each treatment. The majority of US patients discontinue injectable osteoporosis treatment by the end of the first year following initiation. INTRODUCTION: This study was designed to assess the frequency of treatment discontinuation over time among patients who initiate injectable osteoporosis therapies...
January 5, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28057546/in-vitro-and-in-vivo-evaluation-of-a-hydrogel-based-microneedle-device-for-transdermal-electro-modulated-analgesia
#16
Sunaina Indermun, Yahya E Choonara, Pradeep Kumar, Lisa C du Toit, Girish Modi, Regina Luttge, Mershen Govender, Viness Pillay
With a significant portion of the world suffering from chronic pain, the management and treatment of this condition still requires extensive research to successfully mobilize and functionalize its sufferers. This paper details the in vitro and in vivo evaluation of a transdermal Electro-Modulated Hydrogel- Microneedle array (EMHM) device for the treatment of chronic pain. In vitro characterization of the Electro-Modulated Hydrogel was undertaken prior to the determination of the in vivo release, histopathological and pharmacokinetic profiles of the EMHM in a Sprague Dawley rat model...
January 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28057542/an-fc-silenced-igg1-format-with-extended-half-life-designed-for-improved-stability
#17
M Jack Borrok, Neil Mody, Xiaojun Lu, Megan Kuhn, Herren Wu, William F Dall'Acqua, Ping Tsui
Multiple mutation combinations in the IgG Fc have been characterized to tailor immune effector function or IgG serum persistence to fit desired biological outcomes for monoclonal antibody therapeutics. An unintended consequence of introducing mutations in the Fc (particularly the CH2 domain) can be a reduction in biophysical stability which can correlate with increased aggregation propensity, poor manufacturability, and lower solubility. Herein, we characterize the changes in IgG conformational and colloidal stability when two sets of CH2 mutations "TM" (L234F/L235E/P331S) and "YTE" (M252Y/S254T/T256E) are combined to generate an antibody format lacking immune receptor binding and exhibiting extended half-life...
January 2, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28052112/lower-frequency-of-hla-drb1-type-1-diabetes-risk-alleles-in-pediatric-patients-with-mody
#18
Inés Urrutia, Rosa Martínez, Tamara López-Euba, Teresa Velayos, Idoia Martínez de LaPiscina, José Ramón Bilbao, Itxaso Rica, Luis Castaño
OBJECTIVE: The aim of this study was to determine the frequency of susceptible HLA-DRB1 alleles for type 1 diabetes in a cohort of pediatric patients with a confirmed genetic diagnosis of MODY. MATERIALS AND METHODS: 160 families with a proband diagnosed with type 1 diabetes and 74 families with a molecular diagnosis of MODY (61 GCK-MODY and 13 HNF1A-MODY) were categorized at high definition for HLA-DRB1 locus. According to the presence or absence of the susceptible HLA-DRB1 alleles for type 1 diabetes, we considered three different HLA-DRB1 genotypes: 0 risk alleles (no DR3 no DR4); 1 risk allele (DR3 or DR4); 2 risk alleles (DR3 and/or DR4)...
2017: PloS One
https://www.readbyqxmd.com/read/28051309/chemical-modifications-to-rna-a-new-layer-of-gene-expression-regulation
#19
Jinghui Song, Chengqi Yi
The first chemical modification to RNA was discovered nearly 60 years ago; to date, more than 100 chemically distinct modifications have been identified in cellular RNA. With the recent development of novel chemical and/or biochemical methods, dynamic modifications to RNA have been identified in the transcriptome, including N(6)-methyladenosine (m(6)A), inosine (I), 5-methylcytosine (m(5)C), pseudouridine (Ψ), 5-hydroxymethylcytosine (hm(5)C), and N(1)-methyladenosine (m(1)A). Collectively, the multitude of RNA modifications are termed epitranscriptome, leading to the emerging field of epitranscriptomics...
January 12, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28046187/development-of-a-gestational-age-specific-case-definition-for-neonatal-necrotizing-enterocolitis
#20
Cheryl Battersby, Nick Longford, Kate Costeloe, Neena Modi
Importance: Necrotizing enterocolitis (NEC) is a major cause of neonatal morbidity and mortality. Preventive and therapeutic research, surveillance, and quality improvement initiatives are hindered by variations in case definitions. Objective: To develop a gestational age (GA)-specific case definition for NEC. Design, Setting, and Participants: We conducted a prospective 34-month population study using clinician-recorded findings from the UK National Neonatal Research Database between December 2011 and September 2014 across all 163 neonatal units in England...
January 3, 2017: JAMA Pediatrics
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