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Risk factor score for aki

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https://www.readbyqxmd.com/read/27904540/outcome-of-acute-kidney-injury-in-critical-care-unit-based-on-aki-network
#1
Seyed Mohammadreza Hashemian, Hamidreza Jamaati, Behrooz Farzanegan Bidgoli, Farin Rashid Farrokhi, Majid Malekmohammad, Sepehr Roozdar, Seyed Amir Mohajerani, Ahmad Bagheri, Golnar Radmnand, Behzad Hatami, Mandana Chitsazan
BACKGROUND: Acute Kidney Injury (AKI) is an unsolved clinical problem in critical care patients with a high mortality rate, increasing incidence, and no definitive therapy. We studied the incidence, risk factors, and mortality associated with AKI in ICU patients. MATERIALS AND METHODS: In a prospective study, patient demographics, reason for hospitalization, reason for ICU admission, Length of ICU stay, laboratory data, and Vital signs were recorded in prepared forms during the ICU stay...
2016: Tanaffos
https://www.readbyqxmd.com/read/27900737/three-year-mortality-in-30-day-survivors-of-critical-care-with-acute-kidney-injury-data-from-the-prospective-observational-finnaki-study
#2
Henriikka Mildh, Ville Pettilä, Anna-Maija Korhonen, Sari Karlsson, Tero Ala-Kokko, Matti Reinikainen, Suvi T Vaara
BACKGROUND: The role of an episode of acute kidney injury (AKI) in long-term mortality among initial survivors of critical illness is controversial. We aimed to determine whether AKI is independently associated with decreased survival at 3 years among 30-day survivors of intensive care. RESULTS: We included 2336 30-day survivors of intensive care enrolled in the FINNAKI study conducted in seventeen medical-surgical ICUs in Finland during a 5-month period in 2011-2012...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27895419/acute-kidney-injury-and-post-reperfusion-syndrome-in-liver-transplantation
#3
REVIEW
Ilaria Umbro, Francesca Tinti, Irene Scalera, Felicity Evison, Bridget Gunson, Adnan Sharif, James Ferguson, Paolo Muiesan, Anna Paola Mitterhofer
In the past decades liver transplantation (LT) has become the treatment of choice for patients with end stage liver disease (ESLD). The chronic shortage of cadaveric organs for transplantation led to the utilization of a greater number of marginal donors such as older donors or donors after circulatory death (DCD). The improved survival of transplanted patients has increased the frequency of long-term complications, in particular chronic kidney disease (CKD). Acute kidney injury (AKI) post-LT has been recently recognized as an important risk factor for the occurrence of de novo CKD in the long-term outcome...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27875774/risk-factors-for-acute-kidney-injury-in-critically-ill-patients-with-complicated-intra-abdominal-infection
#4
Alejandro Suarez-de-la-Rica, Víctor Anillo, Ana Montero, Carmen Hernandez-Gancedo, Araceli Lopez-Tofiño, Fernando Gilsanz, Emilio Maseda
PURPOSE: The aim was to determine the factors related to acute kidney injury (AKI) in surgical septic patients with complicated intra-abdominal infection (CIAI) and mortality associated to AKI. METHODS: An observational study was performed in patients with CIAI requiring surgery and ICU admission (June 2011-June 2013). Factors at admission associated with developing of AKI and renal replacement therapy (RRT) and association between mortality and AKI and RRT were studied...
November 9, 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27875571/short-and-long-term-mortality-rates-of-elderly-acute-kidney-injury-patients-who-underwent-continuous-renal-replacement-therapy
#5
Harin Rhee, Keum Sook Jang, Jong Man Park, Jin Suk Kang, Na Kyoung Hwang, Il Young Kim, Sang Heon Song, Eun Young Seong, Dong Won Lee, Soo Bong Lee, Ihm Soo Kwak
BACKGROUND: The world's population is aging faster and the incidence of acute kidney injury (AKI) needing continuous renal replacement therapy (CRRT) is increasing in elderly population. The outcome of AKI needing CRRT in elderly patients is known to be poor. However, the definitions of elderly used in the previous literatures were diverse and, there were few data that compared the long-term mortality rates of these patients with middle aged patients. This study was aimed to evaluate this issue...
2016: PloS One
https://www.readbyqxmd.com/read/27852590/development-and-validation-of-a-risk-score-for-prediction-of-acute-kidney-injury-in-patients-with-acute-decompensated-heart-failure-a%C3%A2-prospective-cohort-study-in-china
#6
Li Zhi Zhou, Xiao Bing Yang, Ying Guan, Xing Xu, Ming T Tan, Fan Fan Hou, Ping Yan Chen
BACKGROUND: Although several risk factors for acute kidney injury (AKI) have been identified, early detection of AKI in acute decompensated heart failure patients remains a challenge. The aim of this study was to develop and validate a risk score for early prediction of AKI in acute decompensated heart failure patients. METHODS AND RESULTS: A total of 676 consecutive acute decompensated heart failure participants were prospectively enrolled from 6 regional central hospitals...
November 16, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27802302/a-predictive-model-for-assessing-surgery-related-acute-kidney-injury-risk-in-hypertensive-patients-a-retrospective-cohort-study
#7
Xing Liu, Yongkai Ye, Qi Mi, Wei Huang, Ting He, Pin Huang, Nana Xu, Qiaoyu Wu, Anli Wang, Ying Li, Hong Yuan
BACKGROUND: Acute kidney injury (AKI) is a serious post-surgery complication; however, few preoperative risk models for AKI have been developed for hypertensive patients undergoing general surgery. Thus, in this study involving a large Chinese cohort, we developed and validated a risk model for surgery-related AKI using preoperative risk factors. METHODS AND FINDINGS: This retrospective cohort study included 24,451 hypertensive patients aged ≥18 years who underwent general surgery between 2007 and 2015...
2016: PloS One
https://www.readbyqxmd.com/read/27773638/diagnosis-and-risk-factors-of-acute-kidney-injury-in-very-low-birth-weight-infants
#8
Ankana Daga, Fredrick Dapaah-Siakwan, Sharina Rajbhandari, Cassandra Arevalo, Agnes Salvador
BACKGROUND: Acute kidney injury (AKI) is common in critically ill premature infants. There is a lack of consensus on the diagnostic definition of AKI in very low birth weight (VLBW) infants. The primary aim of this study was to determine the incidence and risk factors for AKI in VLBW infants using the AKI network (AKIN) and pRIFLE (pediatric Risk, Injury, Failure, Loss, End-Stage) criteria and to evaluate whether Clinical Risk Index for Babies (CRIB II) score is a predictor of AKI. The secondary objective was to determine the extent of agreement between the AKIN and pRIFLE criteria in the diagnosis of AKI in VLBW infants...
September 28, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27751901/30-day-readmissions-after-an-acute-kidney-injury-hospitalization
#9
Samuel A Silver, Ziv Harel, Eric McArthur, Danielle M Nash, Rey Acedillo, Abhijat Kitchlu, Amit X Garg, Glenn M Chertow, Chaim M Bell, Ron Wald
BACKGROUND: The risk of hospital readmission in acute kidney injury survivors is not well understood. We estimated the proportion of acute kidney injury patients who were rehospitalized within 30 days and identified characteristics associated with hospital readmission. METHODS: We conducted a population-based study of patients who survived a hospitalization complicated by acute kidney injury from 2003-2013 in Ontario, Canada. The primary outcome was 30-day hospital readmission...
October 14, 2016: American Journal of Medicine
https://www.readbyqxmd.com/read/27744140/asymmetric-dimethylarginine-predicts-the-risk-of-contrast-induced-acute-kidney-injury-in-patients-undergoing-cardiac-catheterization
#10
Tse-Min Lu, Chiao-Po Hsu, Chao-Fu Chang, Chih-Ching Lin, Tzong-Shyuan Lee, Shing-Jong Lin, Wan-Leong Chan
BACKGROUND AND AIMS: Decreased nitric oxide (NO) bioavailability and increased oxidative stress may be involved in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The relationship between asymmetric dimethylarginine (ADMA), an endogenous NO synthase inhibitor, and CI-AKI is unknown. METHODS: We measured plasma ADMA levels in 664 consecutive subjects undergoing cardiac catheterization. Mehran score for predicting the risk of CI-AKI was calculated...
November 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27717384/preoperative-plasma-growth-differentiation-factor-15-for-prediction-of-acute-kidney-injury-in-patients-undergoing-cardiac-surgery
#11
Matthias Heringlake, Efstratios I Charitos, Kira Erber, Astrid Ellen Berggreen, Hermann Heinze, Hauke Paarmann
BACKGROUND: Growth-differentiation factor-15 (GDF-15) is an emerging humoral marker for risk stratification in cardiovascular disease. Cardiac-surgery-associated acute kidney injury (CSA-AKI), an important complication in patients undergoing cardiac surgery, is associated with poor prognosis. The present secondary analysis of an observational cohort study aimed to determine the role of GDF-15 in predicting CSA-AKI compared with the Cleveland-Clinic Acute Renal Failure (CC-ARF) score and a logistic regression model including variables associated with renal dysfunction...
October 8, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27617407/risk-factors-for-acute-kidney-injury-in-patients-with-burn-injury-a-meta-analysis-and-systematic-review
#12
Guosheng Wu, Yongqiang Xiao, Chen Wang, Xudong Hong, Yu Sun, Bing Ma, Guangyi Wang, Zhaofan Xia
Acute kidney injury (AKI) is a fatal complication of burn injury. Few systematic reviews to date have focused on the risk factors predisposing to AKI in patients with burn injury. The aim of this article is to identify the risk factors for the occurrence of AKI in burn patients, thus providing theoretical evidence for prevention and treatment. We performed a systematic review and meta-analysis of studies determining the prevalence, risk factors, and outcomes of AKI in patients with burn injury. An electronic search (up to April 2016) was performed using Pubmed, Embase, Web of Knowledge, and the Cochrane Library databases...
September 9, 2016: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/27595780/comparison-of-acute-kidney-injury-between-abo-compatible-and-abo-incompatible-living-donor-liver-transplantation-a-propensity-matching-analysis
#13
In-Gu Jun, Byungdoo Lee, Seon-Ok Kim, Won-Jung Shin, Ji-Youn Bang, Jun-Gol Song, Gi-Won Song, Sung-Gyu Lee, Gyu-Sam Hwang
The anti-CD20 monoclonal antibody rituximab has significantly decreased the prevalence of antibody-mediated rejection of ABO-incompatible living donor liver transplantation (ABOi LDLT). However, little is known about acute kidney injury (AKI) following ABOi LDLT. The aim of this study was to identify the incidence of AKI in ABOi LDLT and compare it with that of ABO-compatible living donor liver transplantation (ABOc LDLT). We retrospectively collected and analyzed the data of 1617 patients who underwent liver transplant surgery from November 2008 to December 2014...
September 6, 2016: Liver Transplantation
https://www.readbyqxmd.com/read/27561896/genetic-support-for-the-causal-role-of-insulin-in-coronary-heart-disease
#14
Emmi Tikkanen, Matti Pirinen, Antti-Pekka Sarin, Aki S Havulinna, Satu Männistö, Juha Saltevo, Marja-Liisa Lokki, Juha Sinisalo, Annamari Lundqvist, Antti Jula, Veikko Salomaa, Samuli Ripatti
AIMS/HYPOTHESIS: Epidemiological studies have identified several traits associated with CHD, but few of these have been shown to be causal risk factors and thus suitable targets for treatment. Our aim was to evaluate the causal role of a large set of known CHD risk factors using single-nucleotide polymorphisms (SNPs) as instrumental variables. METHODS: Based on published genome-wide association studies (GWASs), we estimated the associations between the established risk factors (blood lipids, obesity, glycaemic traits and BP) and CHD with two complementary approaches: (1) using summary statistics from GWASs to analyse the accordance of SNP effects on risk factors and on CHD; and (2) individual-level analysis where we constructed genetic risk scores (GRSs) in a large Finnish dataset (N = 26,554, CHD events n = 4016)...
November 2016: Diabetologia
https://www.readbyqxmd.com/read/27498291/impaired-brain-metabolism-and-neurocognitive-function-in-childhood-leukemia-survivors-despite-complete-hormone-supplementation-in-adulthood
#15
Cecilia Follin, Eva Marie Erfurth, Aki Johansson, Jimmy Lätt, Pia C Sundgren, Kai Österberg, Gabriella Spulber, Peter Mannfolk, Isabella M Björkman-Burtscher
Cranial radiotherapy is a known risk factor for neurocognitive impairment in survivors of childhood acute lymphoblastic leukemia (ALL). Understanding the nature of cognitive dysfunction during adulthood in ALL survivors is important as it has an impact on major life situations. Thirty-eight (21 women) ALL survivors were investigated 34 years after diagnosis. Median-age was 38 (27-46) years. All were treated with a CRT dose of 24Gy and 11 years (3-13) of complete hormone supplementation. Comparisons were made to 29 matched controls...
November 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27495094/early-postoperative-albumin-level-following-total-knee-arthroplasty-is-associated-with-acute-kidney-injury-a-retrospective-analysis-of-1309-consecutive-patients-based-on-kidney-disease-improving-global-outcomes-criteria
#16
Ha-Jung Kim, Won-Uk Koh, Sae-Gyeol Kim, Hyeok-Seong Park, Jun-Gol Song, Young-Jin Ro, Hong-Seuk Yang
Hypoalbuminemia has been reported to be an independent risk factor for acute kidney injury (AKI). However, little is known about the relationship between the albumin level and the incidence of AKI in patients undergoing total knee arthroplasty (TKA). The aim of our study was to assess incidence and risk factors for AKI and to evaluate the relationship between albumin level and AKI following TKA.The study included a retrospective review of medical records of 1309 consecutive patients who underwent TKA between January 2008 and December 2014...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27491837/dynamic-predictive-scores-for-cardiac-surgery-associated-acute-kidney-injury
#17
Wuhua Jiang, Jie Teng, Jiarui Xu, Bo Shen, Yimei Wang, Yi Fang, Zhouping Zou, Jifu Jin, Yamin Zhuang, Lan Liu, Zhe Luo, Chunsheng Wang, Xiaoqiang Ding
BACKGROUND: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication with a poor prognosis. In order to identify modifiable perioperative risk factors for AKI, which existing risk scores are insufficient to predict, a dynamic clinical risk score to allow clinicians to estimate the risk of CSA-AKI from preoperative to early postoperative periods is needed. METHODS AND RESULTS: A total of 7233 cardiac surgery patients in our institution from January 2010 to April 2013 were enrolled prospectively and distributed into 2 cohorts...
2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27488839/the-predictive-value-of-early-acute-kidney-injury-for-long-term-survival-and-quality-of-life-of-critically-ill-patients
#18
Ivo W Soliman, Jos F Frencken, Linda M Peelen, Arjen J C Slooter, Olaf L Cremer, Johannes J van Delden, Diederik van Dijk, Dylan W de Lange
BACKGROUND: Prognostic factors for the combination of long-term survival and health-related quality of life (HRQoL) after intensive care unit (ICU) stay have not yet been studied. Our aim was to assess whether early acute kidney injury (eAKI), AKI occurring on the first day of ICU admission, is an independent predictor of this combined one-year outcome. METHODS: We included all patients admitted to the mixed ICU of the University Medical Centre Utrecht between July 2009 and April 2013, excluding patients with chronic dialysis, cardiac surgery, and length of stay shorter than 24 hours...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27487001/hemodiafiltration-decreases-serum-levels-of-inflammatory-mediators-in-severe-leptospirosis-a-prospective-study
#19
Sérgio Aparecido Cleto, Camila Eleutério Rodrigues, Ceila Maria Malaque, Jaques Sztajnbok, Antônio Carlos Seguro, Lúcia Andrade
BACKGROUND: Leptospirosis is a health problem worldwide. Its most severe form is a classic model of sepsis, provoking acute respiratory distress syndrome (ARDS) and acute kidney injury (AKI), with associated mortality that remains unacceptably high. We previously demonstrated that early initiation of sustained low-efficiency dialysis (SLED) followed by daily SLED significantly decreases mortality. However, the mode of clearance can also affect dialysis patient outcomes. Therefore, the objective of this study was to compare the effects of SLED with traditional (diffusive) clearance, via hemodialysis, and SLED with convective clearance, via hemodiafiltration (SLEDf), in patients with severe leptospirosis...
2016: PloS One
https://www.readbyqxmd.com/read/27485174/incidence-risk-factors-and-outcomes-of-acute-kidney-injury-aki-in-patients-with-acute-on-chronic-liver-failure-aclf-of-underlying-cirrhosis
#20
Hong Zang, Fangfang Liu, Hongling Liu, Shaoli You, Bing Zhu, Zhihong Wan, Shaojie Xin
BACKGROUND AND AIMS: Acute kidney injury (AKI) is a life-threatening complication in patients with acute-on-chronic liver failure (ACLF) of underlying cirrhosis. However, the characteristics of AKI in these patients have not been clarified. Our aim was to determine the incidence and risk factors of AKI and the association between AKI severity and 180-day transplant-free survival. METHODS: We performed a retrospective cohort analysis of patients with ACLF of underlying cirrhosis in a single center from January 2009 through December 2014...
September 2016: Hepatology International
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