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Lipid Classification

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https://www.readbyqxmd.com/read/29145552/association-between-perceived-barriers-to-diabetes-self-management-and-diabetic-retinopathy-in-asian-patients-with-type-2-diabetes
#1
Ryan Eyn Kidd Man, Eva K Fenwick, Alfred Tau Liang Gan, Charumathi Sabanayagam, Preeti Gupta, Amudha Aravindhan, Tien Yin Wong, Gavin Siew Wei Tan, Ecosse L Lamoureux
Importance: A patient's perceived barriers to diabetes self-management (DSM) may affect his or her risk of diabetic retinopathy (DR); however, few studies have examined this association. Objective: To examine the association between perceived barriers to DSM and the severity spectrum of DR in Asian patients with type 2 diabetes. Design, Setting, and Participants: A cross-sectional clinic-based study, the Singapore Diabetes Management Project, was conducted from December 28, 2010, to March 20, 2013, at the Singapore National Eye Centre, a tertiary eye care institute...
November 16, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/29144590/metabolic-profiling-of-normal-hepatocyte-and-hepatocellular-carcinoma-cells-via-1-h-nuclear-magnetic-resonance-spectroscopy
#2
Yang Chen, Zhong Chen, Jiang-Hua Feng, Yun-Bin Chen, Nai-Shun Liao, Ying Su, Chang-Yan Zou
Hepatocellular carcinoma (HCC) causes death mainly by disseminated metastasis progression from the organ being confined. Different metastatic stages are closely related to cellular metabolic profiles. Normal hepatocyte and HepG2 cell line from low metastatic HCC were studied by NMR-based metabolomic techniques. Multivariate and univariate statistical analyses were utilized to identify characteristic metabolites from cells and cultured media. Elevated levels of acetate, creatine, isoleucine, leucine, and phenylalanine were observed in HepG2 cells, suggesting more active in gathering nutrient components along with altered amino acid metabolisms and enhanced lipid metabolism...
November 16, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29129849/lipoquality-control-by-phospholipase-a2-enzymes
#3
Makoto Murakami
The phospholipase A2 (PLA2) family comprises a group of lipolytic enzymes that typically hydrolyze the sn-2 position of glycerophospholipids to give rise to fatty acids and lysophospholipids. The mammalian genome encodes more than 50 PLA2s or related enzymes, which are classified into several subfamilies on the basis of their structures and functions. From a general viewpoint, the PLA2 family has mainly been implicated in signal transduction, producing bioactive lipid mediators derived from fatty acids and lysophospholipids...
2017: Proceedings of the Japan Academy. Series B, Physical and Biological Sciences
https://www.readbyqxmd.com/read/29114718/ascertainment-of-self-reported-prescription-medication-use-compared-with-pharmaceutical-claims-data
#4
Danijela Gnjidic, Wei Du, Sallie-Anne Pearson, Sarah N Hilmer, Emily Banks
BACKGROUND: Evidence on the comparative validity of self-reported medication use in large-scale studies is limited. This study compared self-reported medication use of prescription-only medications to gold standard pharmaceutical claims (i.e. dispensing) data. METHODS: We selected a random sample of 500 participants from the 45 and Up Study, a large-scale Australian study, with complete ascertainment of Pharmaceutical Benefits Scheme dispensing records. Self-reported medication use was ascertained by questionnaire requesting data on medications used "for most of the last 4 weeks"...
October 11, 2017: Public Health Research & Practice
https://www.readbyqxmd.com/read/29110155/streptomyces-swartbergensis-sp-nov-a-novel-tyrosinase-and-antibiotic-producing-actinobacterium
#5
Marilize le Roes-Hill, Alaric Prins, Paul R Meyers
As part of an antibiotic screening program, an actinobacterium, strain HMC13(T), was isolated from soil collected from the banks of the Gamka River, Western Cape Province, South Africa. The isolate was found to produce branched mycelia that differentiated into spiral spore chains with spiny spores. 16S rRNA gene sequence analysis showed the strain to be closely related to Streptomyces caelestis NRRL 2418(T) (99.72%) and Streptomyces azureus NBRC 12744(T) (99.51%). Chemotaxonomic analyses confirmed the classification of the strain as a member of the genus Streptomyces: LL-DAP in the peptidoglycan, no diagnostic sugars in the whole cell sugar pattern, dominant menaquinones including MK9(H8), MK9(H6), and the polar lipids detected included phosphatidylethanolamine...
November 6, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29104503/the-emerging-roles-of-microparticles-in-diabetic-nephropathy
#6
REVIEW
Chen Chen Lu, Kun Ling Ma, Xiong Zhong Ruan, Bi Cheng Liu
Microparticles (MPs) are a type of extracellular vesicles (EVs) shed from the outward budding of plasma membranes during cell apoptosis and/or activation. These microsized particles then release specific contents (e.g., lipids, proteins, microRNAs) which are active participants in a wide range of both physiological and pathological processes at the molecular level, e.g., coagulation and angiogenesis, inflammation, immune responses. Research limitations, such as confusing nomenclature and overlapping classification, have impeded our comprehension of these tiny molecules...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29098834/-transcriptomics-of-therapeutic-effect-of-huangqi-liuyi-decoction-in-treating-type-2-diabetes
#7
Yue Chang, Jiao Xu, Song Yan, Zhen-Peng Liu, Wei-Chao Ren, Kai-Xue Zhang, Wei Ma, Xiu-Bo Liu
In this study, Illumina sequencing platform was applied in sequencing rat pancreas, counting expression of target points, analyzing expression differences among blank group, model group and Huangqi Liuyi decoction group and exploring the therapeutic effect and mechanism of Huangqi Liuyi decoction on type 2 diabetes mellitus. According to the result, 24.25% of these genes belonged to the unknown functional class, which was the largest classification unit according to the classification analysis of genes by eggNOG...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29095376/circulating-lipids-and-acute-pain-sensitization-an-exploratory-analysis
#8
Angela Starkweather, Thomas Julian, Divya Ramesh, Amy Heineman, Jamie Sturgill, Susan G Dorsey, Debra E Lyon, Dayanjan Shanaka Wijesinghe
BACKGROUND: In individuals with low back pain, higher lipid levels have been documented and were associated with increased risk for chronic low back pain. OBJECTIVES: The purpose of this research was to identify plasma lipids that discriminate participants with acute low back pain with or without pain sensitization as measured by quantitative sensory testing. METHODS: This exploratory study was conducted as part of a larger parent randomized controlled trial...
November 2017: Nursing Research
https://www.readbyqxmd.com/read/29081510/isolation-and-characterization-of-urinary-extracellular-vesicles-implications-for-biomarker-discovery
#9
REVIEW
Michael L Merchant, Ilse M Rood, Jeroen K J Deegens, Jon B Klein
Urine is a valuable diagnostic medium and, with the discovery of urinary extracellular vesicles, is viewed as a dynamic bioactive fluid. Extracellular vesicles are lipid-enclosed structures that can be classified into three categories: exosomes, microvesicles (or ectosomes) and apoptotic bodies. This classification is based on the mechanisms by which membrane vesicles are formed: fusion of multivesicular bodies with the plasma membranes (exosomes), budding of vesicles directly from the plasma membrane (microvesicles) or those shed from dying cells (apoptotic bodies)...
December 2017: Nature Reviews. Nephrology
https://www.readbyqxmd.com/read/29074556/apolipoprotein-e-polymorphisms-are-associated-with-ischemic-stroke-susceptibility-in-a-northwest-china-han-population
#10
Li-Li Zhao, Gang Su, Li-Xia Chen, Qi Yan, Xue-Ping Wang, Wei Yuan, Lei Wang, Zhen-Chang Zhang
Ischemic stroke (IS), the leading neurology cause of death and disability worldwide, is influenced by gene polymorphisms. To explore the association between IS and Apolipoprotein E ( APOE ) gene polymorphisms, a case-control study containing 513 IS patients and 514 controls without IS was conducted in a Northwest China Han population. MassARRAY iPLEX system was applied to determine the APOE polymorphisms according to the alleles of two single nucleotide polymorphisms (SNPs) of APOE, rs429358 and rs7412. The results showed that rs429358 and rs7412 were in Hardy-Weinberg equilibrium (HWE) in both cases and control groups...
October 26, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29071857/-overall-intestinal-permeability-of-multiple-components-in-lotus-leaf-by-in-situ-single-pass-intestinal-perfusion-models
#11
Xiu-Wen Yin, Cheng-Bo Hou, Jiang-Peng Chen, Meng Pan, Xue-Lian Li, Zi-Yu Wang, Ling Dong
To investigate the overall intestinal permeability of multiple components in lotus leaves and make clear the interaction in composition absorption process. Rat single-pass intestinal perfusion technique was used, and the results showed that the Peff values of nuciferine, demethylanuciferine, rutin, quercetin, kaempferol from lotus leaf were greater than 0.5×10⁻⁴ cm•s⁻¹. In the biopharmaceutics classification system (BCS) intestinal permeability property, these ingredients were high permeable components, while the hyperin was low permeable component...
April 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29059183/machine-learning-to-design-integral-membrane-channelrhodopsins-for-efficient-eukaryotic-expression-and-plasma-membrane-localization
#12
Claire N Bedbrook, Kevin K Yang, Austin J Rice, Viviana Gradinaru, Frances H Arnold
There is growing interest in studying and engineering integral membrane proteins (MPs) that play key roles in sensing and regulating cellular response to diverse external signals. A MP must be expressed, correctly inserted and folded in a lipid bilayer, and trafficked to the proper cellular location in order to function. The sequence and structural determinants of these processes are complex and highly constrained. Here we describe a predictive, machine-learning approach that captures this complexity to facilitate successful MP engineering and design...
October 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29058030/prevalence-of-coronary-artery-disease-risk-factors-and-metabolic-syndrome-in-children-with-heart-disease
#13
Adam L Ware, Paul C Young, Cindy Weng, Angela P Presson, L LuAnn Minich, Shaji C Menon
Children with acquired and congenital heart disease (CHD) are increasingly surviving to adulthood. Our aim was to determine the prevalence of coronary artery disease (CAD) risk factors in children at known risk for early CAD or with severe CHD. We recruited children (8-19 years) at risk for early CAD-Kawasaki disease (KD, N = 36) and coarctation (69) or severe CHD: > 1 cardiopulmonary bypass surgery (60), single ventricle (15), prosthetic valves (13). Anthropometric measurements, blood pressure, and fasting lipid data were compared with summaries from National Health and Nutrition Examination Survey (NHANES) publications (1999-2012)...
October 23, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/29048917/a-population-based-study-of-the-prevalence-of-abnormal-uterine-bleeding-and-its-related-factors-among-iranian-reproductive-age-women-an-updated-data
#14
Hadigheh Kazemijaliseh, Fahimeh Ramezani Tehrani, Samira Behboudi-Gandevani, Davood Khalili, Farhad Hosseinpanah, Fereidoun Azizi
BACKGROUND: Abnormal uterine bleeding (AUB) is one of the most common gynecologic complaints among reproductive-age women. The purpose of this study was to investigate the prevalence of AUB and its related factors among reproductive age Iranian women. METHODS: A population-based cross-sectional study was conducted on 1393 women aged 15 - 45 years who participated in the Tehran Lipid and Glucose Study in 2009 - 2012. FIGO terminology and previous definitions were used for classification of AUB...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29042060/australian-general-practitioners-initiate-statin-therapy-primarily-on-the-basis-of-lipid-levels-new-zealand-general-practitioners-use-absolute-risk
#15
REVIEW
Chris Schilling, Josh Knight, Duncan Mortimer, Dennis Petrie, Philip Clarke, John Chalmers, Andrew Kerr, Rod Jackson
OBJECTIVES: To compare the determinants of initial statin prescribing between New Zealand and Australia. New Zealand has a system-wide absolute risk-based approach to primary care cardiovascular disease (CVD) management, while Australia has multiple guidelines. METHOD: Classification and Regression Tree (CART) analysis of two observational studies of primary care CVD management from New Zealand (PREDICT-CVD) and Australia (AusHeart). Over 80% of eligible New Zealanders have been screened for CVD risk...
October 10, 2017: Health Policy
https://www.readbyqxmd.com/read/29041938/development-of-breath-test-for-pneumoconiosis-a-case-control-study
#16
Hsiao-Yu Yang, Ruei-Hao Shie, Che-Jui Chang, Pau-Chung Chen
BACKGROUND: Lipid peroxidation plays an important role in the pathogenesis of pneumoconiosis. Volatile organic compounds (VOCs) generated from lipid peroxidation might be used to detect pneumoconiosis. The objective of this study was to develop a breath test for pneumoconiosis. METHODS: A case-control study was designed. Breath and ambient air were analysed by gas chromatography/mass spectrometry. After blank correction to prevent contamination from ambient air, we used canonical discriminant analysis (CDA) to assess the discrimination accuracy and principal component analysis (PCA) to generate a prediction score...
October 17, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29035735/transcriptome-profiling-identifies-genes-pathways-associated-with-experimental-resistance-to-paromomycin-in-leishmania-donovani
#17
Aditya Verma, Vasundhra Bhandari, Deepak Kumar Deep, Shyam Sundar, Jean Claude Dujardin, Ruchi Singh, Poonam Salotra
Widespread resistance towards antimony and reports of relapses following miltefosine treatment has severely affected the management of visceral leishmaniasis (VL) in the Indian subcontinent. Paromomycin (PMM), an aminoglycoside antibiotic, has been licensed for VL treatment in India in 2007. Although its use is still restricted in the field, unraveling the molecular mechanism of resistance towards PMM is the key to preserve the drug. In this study, PMM resistant lines were selected up to 100 μM of PMM in three distinct field isolates of Leishmania donovani at promastigote stage...
October 10, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29031005/quantitative-high-content-high-throughput-microscopy-analysis-of-lipid-droplets-in-subject-specific-adipogenesis-models
#18
Maxime Bombrun, Hui Gao, Petter Ranefall, Niklas Mejhert, Peter Arner, Carolina Wählby
Neutral lipids packed in lipid droplets (LDs) are essential as a source of fuel for organisms, and specialized storing cells, the adipocytes, provide a buffer for energy variations. Many modern-society-disorders are connected with excess accumulation or deficiency of LDs in adipose tissue. Intracellular LD number and size distribution reflect the tissue conditions, while the associated mechanisms and genes rs are still poorly understood. Large-scale genetic screens using human in vitro differentiated primary adipocytes require cell samples donated from many patients...
October 14, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28989676/rapid-determination-of-medulloblastoma-subgroup-affiliation-with-mass-spectrometry-using-a-handheld-picosecond-infrared-laser-desorption-probe
#19
Michael Woolman, Isabelle Ferry, Claudia M Kuzan-Fischer, Megan Wu, Jing Zou, Taira Kiyota, Semra Isik, Delaram Dara, Ahmed Aman, Sunit Das, Michael D Taylor, James T Rutka, Howard J Ginsberg, Arash Zarrine-Afsar
Medulloblastoma (MB), the most prevalent malignant childhood brain tumour, consists of at least 4 distinct subgroups each of which possesses a unique survival rate and response to treatment. To rapidly determine MB subgroup affiliation in a manner that would be actionable during surgery, we subjected murine xenograft tumours of two MB subgroups (SHH and Group 3) to Mass Spectrometry (MS) profiling using a handheld Picosecond InfraRed Laser (PIRL) desorption probe and interface developed by our group. This platform provides real time MS profiles of tissue based on laser desorbed lipids and small molecules with only 5-10 seconds of sampling...
September 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28989334/masspix-an-r-package-for-annotation-and-interpretation-of-mass-spectrometry-imaging-data-for-lipidomics
#20
Nicholas J Bond, Albert Koulman, Julian L Griffin, Zoe Hall
INTRODUCTION: Mass spectrometry imaging (MSI) experiments result in complex multi-dimensional datasets, which require specialist data analysis tools. OBJECTIVES: We have developed massPix-an R package for analysing and interpreting data from MSI of lipids in tissue. METHODS: massPix produces single ion images, performs multivariate statistics and provides putative lipid annotations based on accurate mass matching against generated lipid libraries...
2017: Metabolomics: Official Journal of the Metabolomic Society
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