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Lipid Classification

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https://www.readbyqxmd.com/read/28102978/pretreatment-cardiometabolic-status-in-youth-with-early-onset-psychosis-baseline-results-from-the-tea-trial
#1
Karsten G Jensen, Christoph U Correll, Ditte Rudå, Dea G Klauber, Marie Stentebjerg-Olesen, Birgitte Fagerlund, Jens Richardt Møllegaard Jepsen, Anders Fink-Jensen, Anne Katrine Pagsberg
OBJECTIVE: To describe pretreatment cardiometabolic constitution in children and adolescents with first-episode psychosis (FEP). METHODS: Baseline cardiometabolic assessment was performed in youths aged 12-17 years with FEP entering the Tolerability and Efficacy of Antipsychotics (TEA) trial and matched healthy controls. Patients were included between June 10, 2010, and January 29, 2014. ICD-10 was used as the diagnostic classification system. Cardiometabolic risk markers were compared between patients versus controls and antipsychotic-naive versus antipsychotic-exposed patients...
January 17, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28086802/brain-metabolic-pattern-analysis-using-a-magnetic-resonance-spectra-classification-software-in-experimental-stroke
#2
Elena Jiménez-Xarrié, Myriam Davila, Ana Paula Candiota, Raquel Delgado-Mederos, Sandra Ortega-Martorell, Margarida Julià-Sapé, Carles Arús, Joan Martí-Fàbregas
BACKGROUND: Magnetic resonance spectroscopy (MRS) provides non-invasive information about the metabolic pattern of the brain parenchyma in vivo. The SpectraClassifier software performs MRS pattern-recognition by determining the spectral features (metabolites) which can be used objectively to classify spectra. Our aim was to develop an Infarct Evolution Classifier and a Brain Regions Classifier in a rat model of focal ischemic stroke using SpectraClassifier. RESULTS: A total of 164 single-voxel proton spectra obtained with a 7 Tesla magnet at an echo time of 12 ms from non-infarcted parenchyma, subventricular zones and infarcted parenchyma were analyzed with SpectraClassifier ( http://gabrmn...
January 13, 2017: BMC Neuroscience
https://www.readbyqxmd.com/read/28079735/incidence-of-local-anesthetic-systemic-toxicity-in-orthopedic-patients-receiving-peripheral-nerve-blocks
#3
Eva E Mörwald, Nicole Zubizarreta, Crispiana Cozowicz, Jashvant Poeran, Stavros G Memtsoudis
BACKGROUND AND OBJECTIVES: Peripheral nerve blocks are increasingly used. However, despite low complication rates, concerns regarding local anesthetic systemic toxicity remain. Although recent studies suggest that this severe complication has decreased considerably, there is a paucity of data about it on a national level. We sought to elucidate the incidence of local anesthetic systemic toxicity on a national level and therefore provide guidance toward the need for preparedness in daily anesthetic practice...
January 9, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28078265/classification-of-31-korean-wheat-triticum-aestivum-l-cultivars-based-on-the-chemical-compositions
#4
Induck Choi, Chon-Sik Kang, Choon-Kee Lee, Sun-Lim Kim
Whole grain wheat flour (WGWF) is the entire grain (bran, endosperm, and germ) milled to make flour. The WGWF of 31 Korean wheat (Triticum aestivum L.) cultivars were analyzed for the chemical compositions, and classified into groups by hierarchical cluster analysis (HCL). The average composition values showed a substantial variation among wheat varieties due to different wheat varieties. Wheat cv. Shinmichal1 (waxy wheat) had the highest ash, lipid, and total dietary fiber contents of 1.76, 3.14, and 15.49 g/100 g, respectively...
December 2016: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28074741/efficiency-of-rosemary-and-basil-essential-oils-on-the-shelf-life-extension-of-atlantic-mackerel-scomber-scombrus-fillets-stored-at-2%C3%A2-c
#5
Romdhane Karoui, Abdo Hassoun
The objective of the present study was to evaluate the impact of rosemary and basil essential oils (EOs) on the qualityof Atlantic mackerel fillets stored at 2°C up to 15 days. Atlantic mackerel (<em>Scomber scombrus</em>) fillets were periodically evaluated to assess their textural, color, physicochemical, and spectral characteristics. The results indicated that rosemary and basil treatments were effective for inhibiting the formation of total volatile basic nitrogen (TVB-N) and lipid oxidation products during storage...
January 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28067049/amniotic-fluid-and-maternal-serum-metabolic-signatures-in-the-2nd-trimester-associated-with-pre-term-delivery
#6
Christina Virgiliou, Helen G Gika, Michael Witting, Anna A Bletsou, Apostolos Athanasiadis, Menelaos Zafrakas, Nikolaos S Thomaidis, Nikolaos Raikos, Georgios Makrydimas, Georgios A Theodoridis
Pre-term delivery (PTD) represents a major health problem which occurs in one in ten births. The hypothesis of the present study was that the metabolic profile of different biological fluids, obtained from pregnant women during the 2nd trimester of gestation, could allow useful correlations with pregnancy outcome. Holistic and targeted metabolomics approaches were applied for the complementary assessment of the metabolic content of prospectively collected amniotic fluid (AF) and paired maternal blood serum samples from 35 women who delivered preterm (between 29weeks+0days and 36weeks +5 days gestation) and 35 women delivered at term...
January 9, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28064075/spectrally-resolved-infrared-microscopy-and-chemometric-tools-to-reveal-the-interaction-between-blue-light-470nm-and-methicillin-resistant-staphylococcus-aureus
#7
Violet V Bumah, Ebrahim Aboualizadeh, Daniela S Masson-Meyers, Janis T Eells, Chukuka S Enwemeka, Carol J Hirschmugl
Blue light inactivates methicillin-resistant Staphylococcus aureus (MRSA), a Gram-positive antibiotic resistant bacterium that leads to fatal infections; however, the mechanism of bacterial death remains unclear. In this paper, to uncover the mechanism underlying the bactericidal effect of blue light, a combination of Fourier transform infrared (FTIR) spectroscopy and chemometric tools is employed to detect the photoreactivity of MRSA and its distinctive pathway toward apoptosis after treatment. The mechanism of action of UV light and vancomycin against MRSA is also investigated to support the findings...
December 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28056297/-potential-mechanism-and-prognostic-value-of-promoter-methylation-of-prdm1-gene-in-diffuse-large-b-cell-lymphoma
#8
X Y Zhang, Z P Ma, W L Cui, R Chen, Abulajiang Glinaer, N Miao, X X Li
Objective: To investigate PRDM1 gene methylation status, immune classification and their prognostic significance in diffuse large B cell lymphoma (DLBCL). Methods: Immunohistochemical (IHC) staining for CD20, CD10, bcl-2, bcl-6, PRDM1/Blimp-1 and MUM1 was carried out in 100 cases of DLBCL specimens and 20 reactive lymphoid proliferation samples. All patients were classified into germinal center B cell-like (GCB) and activated B cell-like (ABC) subtype according to Hans' algorithmin. PRDM1 gene methylation was detected by methylation-specific PCR (MSP) and its relationship with clinicopathologic parameters was analyzed...
December 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/28027565/beyond-vegf-the-weisenfeld-lecture
#9
Joan W Miller
Purpose: To review advances made in the treatment of age-related macular degeneration (AMD) and share perspectives on the future of AMD treatment. Methods: Review of published clinical and experimental studies. Results: Inhibitors of vascular endothelial growth factor (VEGF) truly revolutionized the treatment of AMD. However, available results from longer-term studies suggest that a degenerative process is unveiled, and continues to occur, even when neovascularization is controlled...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28007425/different-golgi-ultrastructure-across-species-and-tissues-implications-under-functional-and-pathological-conditions-and-an-attempt-at-classification
#10
REVIEW
Alexander A Mironov, Irina S Sesorova, Elena V Seliverstova, Galina V Beznoussenko
The Golgi complex (GC) is the central station of the secretory pathway, through which several paths of intracellular transport are connected. The main function of the GC is glycosylation of proteins and lipids, and their subsequent sorting. The structure of the GC is extremely complicated, although in general it is unbelievably similar across different cells types and under different functional and pathological conditions. However, there are also a lot of differences between the GCs in different cells and under different normal and pathological conditions...
December 10, 2016: Tissue & Cell
https://www.readbyqxmd.com/read/27992229/comprehensive-metabolomic-and-lipidomic-profiling-of-human-kidney-tissue-a-platform-comparison
#11
Patrick Leuthold, Elke Schaeffeler, Stefan Winter, Florian Büttner, Ute Hofmann, Thomas E Mürdter, Steffen Rausch, Denise Sonntag, Judith Wahrheit, Falko Fend, Jörg Hennenlotter, Jens Bedke, Matthias Schwab, Mathias Haag
Metabolite profiling of tissue samples is a promising approach for the characterization of cancer pathways and tumor classification based on metabolic features. Here, we present an analytical method for non-targeted metabolomics of kidney tissue. Capitalizing on different chemical properties of metabolites allowed us to extract a broad range of molecules covering small polar molecules and less polar lipid classes that were analyzed by LC-QTOF-MS after HILIC and RP chromatographic separation, respectively. More than 1000 features could be reproducibly extracted and analyzed (CV < 30%) in porcine and human kidney tissue which were used as surrogate matrices for method development...
December 19, 2016: Journal of Proteome Research
https://www.readbyqxmd.com/read/27989744/characterization-of-extracellular-vesicles-by-ir-spectroscopy-fast-and-simple-classification-based-on-amide-and-ch-stretching-vibrations
#12
Judith Mihály, Róbert Deák, Imola Csilla Szigyártó, Attila Bóta, Tamás Beke-Somfai, Zoltán Varga
Extracellular vesicles isolated by differential centrifugation from Jurkat T-cell line were investigated by attenuated total reflection Fourier-transform infrared spectroscopy (ATR-FTIR). Amide and CH stretching band intensity ratios calculated from IR bands, characteristic of protein and lipid components, proved to be distinctive for the different extracellular vesicle subpopulations. This proposed 'spectroscopic protein-to-lipid ratio', combined with the outlined spectrum-analysis protocol is valid also for low sample concentrations (0...
December 16, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27989075/maldi-imaging-mass-spectrometry-as-a-lipidomic-approach-to-heart-valve-research
#13
Peggi M Angel, Ahmed S Bayoumi, Robert B Hinton, Yan Ru Su, David Bichell, John E Mayer, H Scott Baldwin, Richard M Caprioli
BACKGROUND: Valvular disease is characterized in part by lipid deposition, but systematic analysis of the patterns of global lipid expression in healthy and diseased valve tissues are unknown. This is due in part to tissue limitations for lipidomic preparations and technologies for evaluating lipid distribution in tissues. The study aim was to examine the application of matrixassisted laser desorption ionization imaging mass spectrometry (MALDI IMS) to the aortic valve during development and disease, as an approach to detect and map lipids and ultimately better understand valve structure and function...
March 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27976698/epithelial-ovarian-carcinoma-diagnosis-by-desorption-electrospray-ionization-mass-spectrometry-imaging
#14
Maria Luisa Dória, James S McKenzie, Anna Mroz, David L Phelps, Abigail Speller, Francesca Rosini, Nicole Strittmatter, Ottmar Golf, Kirill Veselkov, Robert Brown, Sadaf Ghaem-Maghami, Zoltan Takats
Ovarian cancer is highly prevalent among European women, and is the leading cause of gynaecological cancer death. Current histopathological diagnoses of tumour severity are based on interpretation of, for example, immunohistochemical staining. Desorption electrospray mass spectrometry imaging (DESI-MSI) generates spatially resolved metabolic profiles of tissues and supports an objective investigation of tumour biology. In this study, various ovarian tissue types were analysed by DESI-MSI and co-registered with their corresponding haematoxylin and eosin (H&E) stained images...
December 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27973561/cross-classification-of-human-urinary-lipidome-by-sex-age-and-body-mass-index
#15
Kazuo Okemoto, Keiko Maekawa, Yoko Tajima, Masahiro Tohkin, Yoshiro Saito
Technological advancements in past decades have led to the development of integrative analytical approaches to lipidomics, such as liquid chromatography-mass spectrometry (LC/MS), and information about biogenic lipids is rapidly accumulating. Although several cohort-based studies have been conducted on the composition of urinary lipidome, the data on urinary lipids cross-classified by sex, age, and body mass index (BMI) are insufficient to screen for various abnormalities. To promote the development of urinary lipid metabolome-based diagnostic assay, we analyzed 60 urine samples from healthy white adults (young (c...
2016: PloS One
https://www.readbyqxmd.com/read/27939446/classification-systems-of-secondary-active-transporters
#16
REVIEW
Emelie Perland, Robert Fredriksson
Membrane-bound solute carrier (SLC) transporter proteins are vital to the human body, as they sustain homeostasis by moving soluble molecule as nutrients, drugs, and waste across lipid membranes. Of the 430 identified secondary active transporters in humans, 30% are still orphans, and systematic research has been requested to elaborate on their possible involvement in diseases and their potential as drug targets. To enable this, the various classification systems in use must be understood and used correctly...
December 8, 2016: Trends in Pharmacological Sciences
https://www.readbyqxmd.com/read/27938852/electrocardiographic-measures-of-left-ventricular-hypertrophy-in-the-antihypertensive-and-lipid-lowering-treatment-to-prevent-heart-attack-trial
#17
Michael E Ernst, Barry R Davis, Elsayed Z Soliman, Ronald J Prineas, Peter M Okin, Alokananda Ghosh, William C Cushman, Paula T Einhorn, Suzanne Oparil, Richard H Grimm
Left ventricular hypertrophy (LVH) predicts cardiovascular risk in hypertensive patients. We analyzed baseline/follow-up electrocardiographies in 26,376 Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial participants randomized to amlodipine (A), lisinopril (L), or chlorthalidone (C). Prevalent/incident LVH was examined using continuous and categorical classifications of Cornell voltage. At 2 and 4 years, prevalence of LVH in the C group (5.57%; 6.14%) was not statistically different from A group (2 years: 5...
December 2016: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/27932012/the-burden-of-chronic-noncommunicable-diseases-in-undocumented-migrants-a-1-year-survey-of-drugs-dispensation-by-a-non-governmental-organization-in-italy
#18
G Fiorini, C Cerri, S Bini, A E Rigamonti, S Perlini, N Marazzi, A Sartorio, S G Cella
OBJECTIVES: This study was carried out with two objectives. The first one was to have an insight into the prevalence of chronic noncommunicable diseases (CNCD) in undocumented migrants, and the second one was to evaluate if differences existed among different ethnic groups. STUDY DESIGN: The study is based on the collection of data on drug dispensation by a non-governmental organization (NGO) providing free medical assistance to undocumented migrants in Milan, Italy...
December 2016: Public Health
https://www.readbyqxmd.com/read/27931301/corticosteroid-related-toxicity-in-patients-with-chronic-idiopathic-urticariachronic-spontaneous-urticaria
#19
Dennis Ledford, Michael S Broder, Evgeniya Antonova, Theodore A Omachi, Eunice Chang, Allan Luskin
BACKGROUND: Treatments for patients with chronic idiopathic urticaria (CIU)chronic spontaneous urticaria (CSU) who were unresponsive to antihistamines include oral corticosteroids (OCS). Risks of OCS-related side effects in these patients have not been described quantitatively. OBJECTIVE: To investigate the relationship between OCS use and the risk of developing side effects possibly attributable to OCS and associated health care costs in privately insured patients with CIU/CSU...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27922112/plasma-cathepsin-d-correlates-with-histological-classifications-of-fatty-liver-disease-in-adults-and-responds-to-intervention
#20
Sofie M A Walenbergh, Tom Houben, Sander S Rensen, Veerle Bieghs, Tim Hendrikx, Patrick J van Gorp, Yvonne Oligschlaeger, Mike L J Jeurissen, Marion J J Gijbels, Wim A Buurman, Anita C E Vreugdenhil, Jan Willem M Greve, Jogchum Plat, Marten H Hofker, Satish Kalhan, Jussi Pihlajamäki, Patrick Lindsey, Ger H Koek, Ronit Shiri-Sverdlov
Non-alcoholic steatohepatitis (NASH) is characterized by liver lipid accumulation and inflammation. The mechanisms that trigger hepatic inflammation are poorly understood and subsequently, no specific non-invasive markers exist. We previously demonstrated a reduction in the plasma lysosomal enzyme, cathepsin D (CatD), in children with NASH compared to children without NASH. Recent studies have raised the concept that non-alcoholic fatty liver disease (NAFLD) in adults is distinct from children due to a different histological pattern in the liver...
December 6, 2016: Scientific Reports
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