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https://www.readbyqxmd.com/read/29676358/frequency-distribution-and-immunomorphologic-characteristics-of-peripheral-t-cell-lymphoma-not-otherwise-specified-in-a-tertiary-care-center-in-southern-india
#1
Archana Lakshmanan, Deeksha Sikri, Sushama Patil, Ann Kurian, S Annapurneswari, Sheila Nair
Aims: In world literature, Peripheral T-cell lymphomas (PTCLs) constituted about 12% of non-Hodgkin's lymphomas (NHL) of which PTCL not otherwise specified (NOS) was the most common subtype. This study was undertaken to ascertain the frequency and to assess the morphologic and immunophenotypic characteristics of PTCL, NOS over a period of 5 years in a tertiary care referral center in Southern India. Materials and Methods: Slides and blocks of all PTCL, NOS were retrieved, and a detailed morphologic and immunophenotypic study using a wide panel of antibodies was done...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29661713/review-with-novel-markers-facilitates-precise-categorization-of-41-cases-of-diagnostically-challenging-undifferentiated-small-round-cell-tumors-a-clinicopathologic-immunophenotypic-and-molecular-analysis
#2
Isidro Machado, Akihiko Yoshida, María Gema Nieto Morales, Lucas Faria Abrahão-Machado, Samuel Navarro, Julia Cruz, Javier Lavernia, Antonina Parafioriti, Piero Picci, Antonio Llombart-Bosch
BACKGROUND: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable. DESIGN: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis...
November 29, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29651643/splenosis-a-great-mimicker-of-neoplastic-disease
#3
REVIEW
Yasmeen K Tandon, Christopher P Coppa, Andrei S Purysko
Splenosis is a benign condition that can occur after splenic trauma or after surgery involving the spleen. These splenic implants are most often seen within the abdominal and pelvic cavities. On imaging, splenosis can be confused with multiple additional entities including metastatic disease, peritoneal carcinomatosis, peritoneal mesothelioma, abdominal lymphoma, renal cancer, hepatic adenomas, or endometriosis depending on its distribution. In all patients with history of splenic surgery or trauma, splenosis should be on the differential diagnosis of soft tissue nodules in the abdomen and pelvis, especially in the absence of systemic symptoms, to avoid unnecessary biopsy, chemotherapy, or surgery...
April 12, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29651368/synchronous-pulmonary-neoplasms-a-chance-occurrence-or-is-there-more-than-meets-the-eye
#4
Uroosa Ibrahim, Amina Saqib, Manisha Pant, Gwenalyn Garcia, Marcel Odaimi
Primary bronchus-associated lymphoid tissue (BALT) lymphoma comprises 5% of non-Hodgkin's lymphoma (NHL) and usually has an indolent course. Synchronous primary lung cancers with BALT lymphoma are seldom seen in patients with adenocarcinoma of the lung. Synchronous squamous cell carcinoma (SCC) and BALT lymphoma is an extremely rare occurrence. We report an unusual case of stage 4 BALT lymphoma requiring treatment that revealed an underlying ipsilateral mass causing a diagnostic dilemma. An 84-year-old female with a history of systemic lupus erythematosus, deep vein thrombosis, and thrombotic microangiopathy presented to the hospital with cough and dyspnea on exertion...
February 6, 2018: Curēus
https://www.readbyqxmd.com/read/29607824/lymphoid-proliferation-in-eyelid-a-primary-follicular-lymphoma-case
#5
Deivy Cruzado-Sánchez, Walter Andree Tellez, Solon Serpa-Frias, Grisnery Maquera
Ocular adnexal lymphoma (OAL) constitutes 8% of all extranodal lymphomas, being rare in the eyelids (5-20%). The objective was to report a case of eyelid follicular lymphoma in a young adult woman. A 35-year-old female with swelling in left lower eyelid with development for 2 months. The visual acuity was 20/20 in both eyes, the tumor mass was 3 cm wide and 1.5 cm long. The contrast-enhanced computed tomography showed a soft-tissue injury in the left lower eyelid but had no signs of local spread according to description...
January 2018: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29602182/disease-site-as-a-determinant-of-survival-outcome-in-patients-with-systemic-anaplastic-lymphoma-kinase-positive-anaplastic-large-cell-lymphoma-with-extranodal-involvement-an-analysis-of-1306-cases-from-the-us-national-cancer-database
#6
Kevin A Nguyen, Chang Su, Harrison X Bai, Zishu Zhang, Rong Xiao, Giorgos Karakousis, Paul J Zhang, Guiying Zhang
Systemic anaplastic lymphoma kinase positive (ALK+) anaplastic large cell lymphoma with extranodal involvement (ALCL-E) is a rare form of non-Hodgkin lymphoma. No large study in the literature has compared the survival outcomes among different primary extranodal sites of involvement in ALK+ ALCL-E. We identified 1306 patients with ALK+ ALCL-E diagnosed between 2004 and 2014 in the US National Cancer Database, among whom 387 had primary extranodal site in the chest/abdomen/pelvis, 103 in the bone, 62 in the central nervous system, 134 in the head and neck and 620 in the cutaneous/soft tissue...
March 30, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29600200/primary-lymphoma-of-the-pelvis-a-case-report
#7
Karem M Zekry, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroyuki Tsuchiya
Introduction: Primary lymphoma of the bone (PLB) is uncommon clinical entity with the vast majority of the cases are non-Hodgkin's lymphoma. Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of PLB. Case Report: We report a case of 60-year-old female presented with pain in the right hip that persisted for 2 months. Plain X-ray, computed tomography, and magnetic resonance imaging of the right hip showed a lytic lesion involving the right acetabulum and adjoining iliac bone with extraosseous mass...
November 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29588915/recurrent-8-year-ongoing-unilateral-breast-seroma-formation-after-pip-implant-removal-a-case-report-and-review-of-the-literature
#8
Sonja Kästner, Felix Julian Paprottka, Phillipp Gonser, Manuel De Villegas López, Kai Oliver Kaye
Late seroma formation is a rare complication after implant-based breast enlargement surgery and even less frequent after implant removal. This case report presents a case of painful recurrent seroma formation after the removal of a ruptured Poly Implants Prothèse implant. A 52-year-old patient presented herself in our clinic with a clinical history of recurrent unilateral seroma of the right breast over a period of 8 years after the initial unilateral implant removal. Removal of the remaining implant and complete bilateral capsulectomy was performed...
January 2018: Surgery Journal
https://www.readbyqxmd.com/read/29564828/genes-proteins-and-biological-pathways-preventing-chromothripsis
#9
Martin Poot
The highly complex structural genome variations chromothripsis, chromoanasynthesis, and chromoplexy are subsumed under the term chromoanagenesis, which means chromosome rebirth. Precipitated by numerous DNA double-strand breaks, they differ in number of and distances between breakpoints, associated copy number variations, order and orientation of segments, and flanking sequences at joining points. Results from patients with the autosomal dominant cancer susceptibility disorder Li-Fraumeni syndrome implicated somatic TP53 mutations in chromothripsis...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29563728/aggressive-angioimmunoblastic-t-cell-lymphomas-aitl-with-soft-tissue-extranodal-mass-varied-histopathological-patterns-with-peripheral-blood-bone-marrow-and-splenic-involvement-and-review-of-literature
#10
Tanushri Mukherjee, Rajat Dutta, S Pramanik
Angioimmunoblastic T cell lymphoma (AITL) is a peripheral T cell non-Hodgkin lymphoma with an aggressive fatal course and it has varied clinical presentation with an uncommon presentation when they present as soft tissue masses or when there is spill in the peripheral blood or there are composite lymphomas that are rare presentations. Common presentations include lymphadenopathy, fever and systemic symptoms, hemolytic anemias, skin rashes, and rheumatoid arthritis. The classical histopathology is absence of follicles in lymph nodes with presence of high endothelial venules and the tumor cells of small to medium-sized lymphocytes with pale cytoplasm mixed with reactive T cells...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29559881/atypical-presentation-of-extramedullary-plasmacytoma
#11
Eric Wallace, Zachary Stewart, David Theriot, William Shaffer, Shane Guillory, Michael Hanemann, Raman Danrad, Bradley Spieler
Background: Plasmacytomas are monoclonal proliferations of plasma cells that typically affect the intramedullary axial skeleton. Imaging findings of an extramedullary plasmacytoma on radiograph and computed tomography can be nonspecific and can resemble other entities such as lymphoma, metastases, chondrosarcomas, or giant cell tumors. Case Report: A 60-year-old female with a medical history of partial complex seizures, hypertension, diabetes, glaucoma, and hyperlipidemia presented with complaints of superficial abdominal pain associated with erythema and swelling for 3 weeks...
2018: Ochsner Journal
https://www.readbyqxmd.com/read/29557349/oral-and-maxillofacial-tumours-in-children-and-adolescents-clinicopathologic-audit-of-75-cases-in-an-academic-medical-centre-sokoto-northwest-nigeria
#12
Abdurrazaq Olanrewaju Taiwo, Ramat Oyebunmi Braimah, Adebayo Aremu Ibikunle, Mutiat Feyisetan Obileye, Nma Muhammed Jiya, Saddiku Malami Sahabi, Idris Kabiru Jaja
Background: Maxillofacial tumours in children and adolescents have been documented worldwide; however, few studies were reported from Africa, especially sub-Saharan Africa. In Nigeria, most of the studies emanated from the Southwest region. Aim: To present an audit of clinicopathologic features and treatment of orofacial tumours in children and adolescents in Sokoto, Northwest Nigeria. Patients and Methods: Clinicopathologic records of the Departments of Dental and Maxillofacial Surgery, Paediatrics and Histopathology, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria, were reviewed for all the oral and maxillofacial tumours managed in children <19 years from January 2011 to December 2015...
July 2017: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/29552352/cutaneous-non-epitheliotropic-t-cell-lymphoma-associated-with-a-fracture-site-in-a-cat
#13
Selvi Jegatheeson, Julie Wayne, Laura K Brockley
Case summary: A 7-year-old male neutered domestic shorthair cat presented for investigation of a swelling over the right forelimb. Radiographs of the right forelimb revealed significant lysis and soft tissue swelling surrounding a previously implanted surgical plate, used to repair a fracture of the distal radius 5 years prior. The implant was removed, and a biopsy was collected. Histopathological analysis and immunohistochemistry diagnosed a non-epitheliotropic T-cell cutaneous lymphoma...
January 2018: JFMS Open Reports
https://www.readbyqxmd.com/read/29547041/a-case-of-extranodal-metastasis-of-primary-bone-lymphoma-in-the-lower-extremity
#14
Elizabeth Hernandez, Raymond Rowan, Martina Randall
Primary bone lymphoma is a rare disease, accounting for less than 5% of all extranodal lymphoma. Although the femur is cited as being the most common site, primary bone lymphoma is rare, accounting for less than 1% of all non-Hodgkin's lymphoma. Herein we present a case of diffuse B-cell-type malignant lymphoma manifested as a large soft-tissue mass of the leg, via metastasis of primary non-Hodgkin's lymphoma of the femur, which went untreated. We highlight the advantages of various imaging modalities used throughout the process of diagnosis and treatment because accurate and early diagnosis are essential...
January 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29545962/subcutaneous-granulomatous-inflammation-due-to-basidiobolomycosis-case-reports-of-3-patients-in-buruli-ulcer-endemic-areas-in-benin
#15
Luc V C Brun, Jean Jacques Roux, Ghislain E Sopoh, Julia Aguiar, Miriam Eddyani, Wayne M Meyers, Dirk Stubbe, Marie T Akele Akpo, Françoise Portaels, Bouke C de Jong
Background: Basidiobolomycosis is a rare subcutaneous mycosis, which can be mistaken for several other diseases, such as soft tissue tumors, lymphoma, or Buruli ulcer in the preulcerative stage. Microbiological confirmation by PCR for Basidiobolus ranarum and culture yield the most specific diagnosis, yet they are not widely available in endemic areas and with varying sensitivity. A combination of histopathological findings, namely, granulomatous inflammation with giant cells, septate hyphal fragments, and the Splendore-Hoeppli phenomenon, can confirm basidiobolomycosis in patients presenting with painless, hard induration of soft tissue...
2018: Case Reports in Pathology
https://www.readbyqxmd.com/read/29497455/primary-cutaneous-non-hodgkin-s-lymphoma-clinically-mimicking-a-soft-tissue-sarcoma
#16
Prajwala Gupta, Poojan Agarwal, Arvind Ahuja, C K Durga
Primary cutaneous B-cell lymphomas (PCBCL) are a heterogeneous group of neoplasms with distinct biology and clinical course when compared to their nodal counterparts. They usually present as violaceous, erythematous plaques, and nonulcerated nodules, which are confined to skin at the time of presentation. We present an unusual case of primary cutaneous diffuse large B-cell lymphoma, clinically mimicking a sarcoma. This case highlights the uncommon aggressive behavior and ulcerated type of nodular lesions seen in PCBCL and also revisits the cytomorphological findings of the same...
2018: CytoJournal
https://www.readbyqxmd.com/read/29497333/patients-with-osteosarcoma-and-soft-tissue-sarcoma-might-become-cancer-refugees-in-some-japanese-regional-cities
#17
Hiromichi Yamane, Toshiyuki Kunisada, Toshifumi Ozaki, Nobuaki Ochi, Yoshihiro Honda, Yasunari Nagasaki, Nozomu Nakagawa, Tomoko Yamagishi, Hidekazu Nakanishi, Nagio Takigawa
Purpose: "Rare cancer" is defined as malignancy with a disease prevalence (age-adjusted incidence rate) of less than six per 100,000 population. Proper treatments which these patients need cannot always be performed unless they find dedicated facilities. Patients tend to be desperate, searching for advice and care. Thus, they are called "cancer refugees". Osteosarcoma and soft tissue sarcoma (OS/STS) are representative rare cancers in Japan. We conducted a retrospective analysis of patients with OS/STS to improve the current treatment modalities in a Japanese regional city...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29495920/multifocal-vertebral-sclerosing-bone-changes-and-soft-tissue-masses-caused-by-hodgkin-s-lymphoma-in-a-patient-with-systemic-lupus-erythematosus-a-case-report
#18
S Krabbe, J Helweg-Larsen, A Loft, S Jacobsen
No abstract text is available yet for this article.
March 2, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29492099/diagnostic-validity-of-fine-needle-capillary-cytology-in-palpable-tumours-at-the-oncology-institute-of-peru
#19
Milagros Abad-Licham, Jose Galvez-Olortegui, Juan Astigueta, Juan Díaz-Plasencia
Objective: To evaluate the diagnostic validity of fine-needle capillary cytology (FNCC) in palpable tumours. Material and methods: A retrospective, single-tray, cross-sectional diagnostic test study was carried out. We reviewed the cytological reports of the case files of the Cytology Unit of the Northern Regional Institute of Neoplastic Diseases (IREN) from January 2012 to December 2016. Results: A total of 332 patients were selected, with an average age of 54...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29484620/air-pollution-from-industrial-waste-gas-emissions-is-associated-with-cancer-incidences-in-shanghai-china
#20
Xiaowei Cong
Outdoor air pollution may be associated with cancer risk at different sites. This study sought to investigate outdoor air pollution from waste gas emission effects on multiple cancer incidences in a retrospective population-based study in Shanghai, China. Trends in cancer incidence for males and females and trends in waste gas emissions for the total waste gas, industrial waste gas, other waste gas, SO2 , and soot were investigated between 1983 and 2010 in Shanghai, China. Regression models after adjusting for confounding variables were constructed to estimate associations between waste gas emissions and multiple cancer incidences in the whole group and stratified by sex, Engel coefficient, life expectancy, and number of doctors per 10,000 populations to further explore whether changes of waste gas emissions were associated with multiple cancer incidences...
February 27, 2018: Environmental Science and Pollution Research International
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