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Pancreatic neoplasm

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https://www.readbyqxmd.com/read/29912000/neoplasms-of-the-neuroendocrine-pancreas-an-update-in-the-classification-definition-and-molecular-genetic-advances
#1
Julie M Guilmette, Vania Nosé
This review focuses on discussing the main modifications of the recently published 2017 WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent updates separate pancreatic neuroendocrine tumors into 2 broad categories: well-differentiated pancreatic neuroendocrine tumors (panNET) and poorly differentiated pancreatic neuroendocrine carcinoma (panNEC), and incorporates a new subcategory of "well-differentiated high-grade NET (G3)" to the well-differentiated NET category. This new classification algorithm aims to improve the prediction of clinical outcomes and survival and help clinicians select better therapeutic strategies for patient care and management...
June 14, 2018: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/29908985/biodistribution-and-toxicity-assessment-of-intratumorally-injected-arginine-glycine-aspartic-acid-peptide-conjugated-to-cdse-zns-quantum-dots-in-mice-bearing-pancreatic-neoplasm
#2
Ming-Ming Li, Jia Cao, Jia-Chun Yang, Yu-Jie Shen, Xiao-Lei Cai, Yuan-Wen Chen, Chun-Ying Qu, Yi Zhang, Feng Shen, Min Zhou, Lei-Ming Xu
Quantum dots (QDs) conjugated with arginine-glycine-aspartic acid (RGD) peptides (which are integrin antagonists) are novel nanomaterials with the unique optical property of high molar extinction coefficient, and they have potential utility as photosensitizers in photodynamic therapy (PDT). Our group previously demonstrated significant benefits of using PDT with QD-RGD on pancreatic tumor cells. This study aimed to evaluate the biodistribution and toxicity of QD-RGD in mice prior to in vivo application. Mice with pancreatic neoplasms were intratumorally injected with varying doses of QD-RGD, and the biodistribution 0-24 h post injection was compared to that in control mice (intravenously injected with unconjugated QD)...
June 14, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29906691/intraductal-tubulopapillary-neoplasm-of-the-pancreas-presenting-as-recurrent-acute-pancreatitis-a-case-report
#3
Sodai Sakamoto, Yosuke Tsuruga, Yuki Fujii, Hiroki Shomura, Atsuo Hattori, Keizo Kazui
INTRODUCTION: The 2010 World Health Organization classification of intraductal neoplasms of the pancreas includes intraductal tubulopapillary neoplasms (ITPNs) and intraductal papillary mucinous neoplasms, the latter being a rare and new concept. ITPN sometimes cause acute pancreatitis; therefore, distinguishing ITPN from idiopathic acute pancreatitis is important but challenging. PRESENTATION OF CASE: We present the case of a 72-year-old male who had recurrent pancreatitis for the past 2 years, his diagnosis was idiopathic acute pancreatitis...
June 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29906625/computed-tomography-and-magnetic-resonance-imaging-findings-of-pancreatic-hamartoma-a-case-report-and-literature-review
#4
Yeo Eun Han, Beom Jin Park, Deuk Jae Sung, Min Ju Kim, Na Yeon Han, Ki Choon Sim, Sung Bum Cho, Joo Young Kim
Pancreatic hamartoma is a rare benign malformation that resembles a neoplasm and may be mistaken for a malignancy. The imaging findings of pancreatic hamartoma are not well established, as only one radiological case report has been described since 1983. Herein, we discussed a case of pancreatic hamartoma in a 35-year-old woman and conducted a literature review focused on imaging findings and differential diagnosis of pancreatic hamartoma. Increased late enhancement on post-contrast dynamic study and absence of diffusion restriction may be characteristic MR imaging findings of pancreatic hamartoma that may narrow the differential diagnosis of hypervascular pancreatic lesions...
June 6, 2018: Clinical Imaging
https://www.readbyqxmd.com/read/29904461/pancreatic-arteriovenous-malformation-mimicking-pancreatic-neoplasm-a-systematic-multimodality-diagnostic-approach-and-treatment
#5
Olga Nikolaidou, Ekaterini Xinou, Pavlos Papakotoulas, Andis Philippides, Dimitra Panagiotopoulou-Boukla
Pancreatic arteriovenous malformation (pAVM) is a very rare entity, as less than 100 cases are reported in the international literature. Patients with pAVM may be asymptomatic or may present a wide range of symptoms, such as vague pain, feeling of fullness, gastrointestinal bleeding, or even portal hypertension. We present the multimodality approach in the diagnosis of a patient with pAVM and treatment via transcatheter arterial embolization of the lesion using steel coils. The patient was free of symptoms 12 months later...
April 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29900747/a-study-of-a-pancreatic-mass-not-all-is-what-it-seems
#6
Irene Andaluz García, Cristina Suárez Ferrer, Pedro Mora Sanz
We report the case of a male with no medical history with acute cholangitis secondary to a pancreatic head´s mass suggestive of neoplasm. An EUS-FNA was performed where no atypical cells were identified but a granulomatous component did. The patient was finally diagnosed of disseminated tuberculosis with pancreatic involvement. Pancreatic tuberculosis is an infrequent entity that requires a high index of suspicion due to the variability of its forms of presentation and the high morbidity and mortality without targeted therapy...
June 14, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29899870/biomarkers-for-the-risk-of-thrombosis-in-pancreatic-adenocarcinoma-are-related-to-cancer-process
#7
Dorothée Faille, Marie-Charlotte Bourrienne, Emmanuelle de Raucourt, Luc de Chaisemartin, Vanessa Granger, Romaric Lacroix, Laurence Panicot-Dubois, Pascal Hammel, Philippe Lévy, Philippe Ruszniewski, Nadine Ajzenberg, Vinciane Rebours
Background: Venous thrombo-embolic events (VTE) frequently occur in patients with pancreatic ductal adenocarcinoma (PDAC) and contribute to high morbidity and mortality. Objectives: To determine whether VTE biomarkers are related to cancer, inflammation or precancerous states and to assess their relevance to predict VTE in PDAC. Patients and Methods: We compared VTE biomarkers in patients with PDAC ( n = 42), intraductal papillary mucinous neoplasm of the pancreas (IPMN, n = 48) or chronic pancreatitis ( n = 50)...
May 29, 2018: Oncotarget
https://www.readbyqxmd.com/read/29899320/pancreatic-cystic-lesions-pathogenesis-and-malignant-potential
#8
REVIEW
Antoinette J Pusateri, Somashekar G Krishna
Pancreatic cancer remains one of the most lethal cancers despite extensive research. Further understanding of precursor lesions may enhance the ability to treat and prevent pancreatic cancer. Pancreatic cystic lesions (PCLs) with malignant potential include: mucinous PCLs (intraductal papillary mucinous neoplasms and mucinous cystic neoplasm), solid pseudopapillary tumors and cystic neuroendocrine tumors. This review summarizes the latest literature describing what is known about the pathogenesis and malignant potential of these PCLs, including unique epidemiological, radiological, histological, genetic and molecular characteristics...
June 13, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29898902/neoplasms-reported-with-liraglutide-or-placebo-in-people-with-type-2-diabetes-results-from-the-leader-randomized-trial
#9
Michael A Nauck, Thomas Jon Jensen, Carina Rosenkilde, Salvatore Calanna, John B Buse
OBJECTIVE: This study explored neoplasm risk with liraglutide versus placebo in the LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results) cohort. RESEARCH DESIGN AND METHODS: LEADER (NCT01179048) was an international, phase 3b, randomized, double-blind, controlled trial. Participants aged ≥50 years with type 2 diabetes and high cardiovascular risk were assigned 1:1 to receive liraglutide (≤1.8 mg daily; n = 4,668) or placebo ( n = 4,672) in addition to standard care and monitored for 3...
June 13, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29896274/risk-factors-of-the-recurrences-of-pancreatic-solid-pseudopapillary-tumors-a-systematic-review-and-meta-analysis
#10
Hao Gao, Yong Gao, Lingdi Yin, Guangfu Wang, Jishu Wei, Kuirong Jiang, Yi Miao
Background: Pancreatic solid pseudopapillary tumors (SPTs) are rare neoplasms with low-grade malignancy. The main treatment for them is surgical resection. However, some SPTs relapse after resection. The risk factors associated with the recurrences of resected SPTs remain controversial to date. We performed a systematic review and meta-analysis to identify the risk factors of the recurrences of pancreatic SPTs. Materials and Methods: We searched PubMed, EMBASE, and the Cochrane Library from their inception to December 2017...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29895203/pregnancy-after-whipple-procedure-a-new-case-and-review-of-the-literature
#11
Giulia Magoga, Laura Felder, Francesco Palazzo, Vincenzo Berghella
BACKGROUND: Whipple procedure is a complex operation usually performed to treat periampullary neoplasms. There are only four case reports of five pregnancies after Whipple procedure, with limited evidence about how to manage pregnancy after this surgery. CASE: A 28-year-old gravida 5 Para 2022 presented to our hospital at 20 weeks with worsening depression. She had a history of Whipple for a solid pseudopapillary neoplasm of the pancreas followed by two pregnancies...
June 12, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29893579/eus-fna-cytological-material-from-pancreatic-lesions-the-expression-of-cathepsins-and-its-predictive-value-of-malignancy
#12
Manuela Roger, Juan Martínez, Gloria Peiró, Jose Ramón Aparicio, Francisco Ruiz, Luís Compañy, Juan Antonio Casellas
AIMS: To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC). METHODS: We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples. RESULTS: Seventeen FNA were performed...
June 12, 2018: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/29890488/pancreatobiliary-fistula-associated-with-intraductal-papillary-mucinous-carcinoma-accompanying-obstructive-jaundice-a-case-report
#13
Toshiaki Komo, Koichi Oishi, Toshihiko Kohashi, Jun Hihara, Mikihiro Kanou, Akira Nakashima, Mayumi Kaneko, Hidenori Mukaida, Naoki Hirabayashi
INTRODUCTION: Intraductal papillary mucinous neoplasms (IPMNs) occasionally involve formation of fistulas with other adjacent organs. Pancreatobiliary fistulas associated with IPMNs are rare, but affected patients often develop obstructive jaundice and cholangitis. PRESENTATION OF CASE: A 79-year-old man was referred to our hospital for evaluation of abnormal biliary enzymes. Contrast-enhanced computed tomography and endoscopic retrograde cholangiopancreatography demonstrated multiple cystic lesions with septa in the pancreatic head and fistulas between the cystic lesions and common bile duct...
June 4, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29888404/hepatobiliary-and-pancreatic-pancreatic-mixed-serous-neuroendocrine-neoplasm-in-von-hippel-lindau-disease
#14
M Yamashima, E Ozawa, K Ohnita, K Tabata, K Natsuda, S Ono, M Hidaka, S Eguchi, K Nakao
No abstract text is available yet for this article.
June 10, 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29888283/using-crispr-cas9-to-knock-out-amylase-in-acinar-cells-decreases-pancreatitis-induced-autophagy
#15
Kohei Yasunaga, Tetsuhide Ito, Masami Miki, Keijiro Ueda, Takashi Fujiyama, Yuichi Tachibana, Nao Fujimori, Ken Kawabe, Yoshihiro Ogawa
Pancreatic cancer is a malignant neoplasm that originates from acinar cells. Acinar cells get reprogrammed to become duct cells, resulting in pancreatic cancer. Pancreatitis is an acinar cell inflammation, leading to "impaired autophagy flux". Pancreatitis promotes acinar-to-ductal transdifferentiation. Expression of amylase gets eliminated during the progression of pancreatic cancer. Amylase is considered as an acinar cell marker; however, its function in cells is not known. Thus, we investigated whether amylase affects the acinar cell autophagy and whether it plays any role in development of pancreatitis...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29887705/outcome-of-pancreaticoduodenectomy-at-low-volume-centre-in-tier-ii-city-of-india
#16
Kumar Vinchurkar, Vishwanath M Pattanshetti, Manoj Togale, Santosh Hazare, Varadraj Gokak
Currently, pancreaticoduodenectomy (PD) is considered a common and feasibly performed surgery for periampullary tumours, but it is still a high-risk surgical procedure with potential morbidity and mortality rates. Previously, it was emphasised for the need of high-volume centres to perform specialised surgery such as PD. The authors have made an attempt to know the relation between low-volume centre and outcomes of PD. The study was conducted in a Tier-II city referral hospital located in Karnataka, India. A total of 37 patients with suspected periampullary neoplasms underwent surgical exploration with curative intent over a period of 4 years, i...
June 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29886564/managing-incidental-pancreatic-cysts
#17
REVIEW
Jennifer Phan, V Raman Muthusamy
PURPOSE OF REVIEW: The goal of this review is to critically analyze the current literature regarding the management of incidental pancreatic cysts. Given their increased rates of detection due to the frequent use of cross-sectional imaging, correctly identifying the subset of high risk lesions that are appropriate for surgical resection is critical. However, the existing consensus and societal guidelines discussed in this review lack high quality data to create evidence-based recommendations, making achieving this important aim challenging...
June 9, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29882386/steroidogenesis-in-ovarian-like-mesenchymal-stroma-of-hepatic-and-pancreatic-mucinous-cystic-neoplasms
#18
Hiroyuki Kumata, Keigo Murakami, Kazuyuki Ishida, Shigehito Miyagi, Atsushi Arakawa, Yoshiaki Inayama, Keiichi Kinowaki, Atsushi Ochiai, Motohiro Kojima, Michiyo Higashi, Suzuko Moritani, Kyoko Kuwahara, Yukio Nakatani, Dai Kajiura, Gen Tamura, Hiroshi Kijima, Mitsunori Yamakawa, Taizo Shiraishi, Yukinori Inadome, Kazuhiro Murakami, Hiroyoshi Suzuki, Takashi Sawai, Michiaki Unno, Takashi Kamei, Hironobu Sasano
Mucinous cystic neoplasms (MCNs) occur in the ovary, pancreas and retroperitoneum but very rarely in the liver. MCNs are known to harbor ovarian-like mesenchymal stroma (OLS) expressing progesterone- and estrogen receptors. In this study we evaluated steroidogenesis in OLS of 25 hepatic MCNs and 24 pancreatic MCNs. Both steroid receptors and steroidogenic factors were immunohistochemically evaluated using H-score and results were compared with those in 15 ovarian MCNs and 10 normal ovaries. Androgen receptor (AR) H-scores in OLS were significantly higher in hepatic, pancreatic and ovarian MCN than those in normal ovaries...
June 7, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29882285/diagnosis-of-paraganglioma-as-a-pancreatic-mass-a-case-report
#19
Elise Nguyen, Manando Nakasaki, Thomas K Lee, Di Lu
Paragangliomas are rare neoplasms that arise from the chromaffin cells of the autonomic nervous system. Although paragangliomas can occur anywhere paraganglia are present, they tend to occur in the head, neck, and retroperitoneum. Rarely, paragangliomas can occur in the peripancreatic area and present as a pancreatic mass, creating a diagnostic challenge for the clinician, radiologist, and pathologist. Here, we present a case of a 70-year-old woman with history of breast carcinoma who presented with chronic constipation, early satiety, and an abdominal mass...
June 7, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29876615/-oligometastases-of-neuroendocrine-tumors-extent-of-surgery
#20
REVIEW
F Bösch, J Werner, M K Angele, M O Guba
Neuroendocrine tumors (NETs) are rare neoplasms, which represent complex challenges in diagnosis and treatment. Even in the metastatic stage there are important differences in the type of tumor in comparison to gastrointestinal and pancreatic adenocarcinomas. Therefore, the disease courses are substantially different depending on the grade of differentiation. Even in the metastatic stage the 5‑year survival rates of G1 tumors is up to 83%. Approximately 20% of small intestine NETs additionally show hormone activity, which can compromise survival and the quality of life...
June 6, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
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