Ana Catarina Cristovão-Silva, Maria Carolina Accioly Brelaz-de-Castro, Elis Dionisio da Silva, Ana Cristina Lima Leite, Lizandra Beatriz Amorim Alves Santiago, Juliana Maria da Conceição, Robert da Silva Tiburcio, Davi Pereira de Santana, Danilo Cesar Galindo Bedor, Breno Ítalo Valença de Carvalho, Luiz Felipe Gomes Rebello Ferreira, Rafael de Freitas E Silva, Valéria Rêgo Alves Pereira, Marcelo Zaldini Hernandes
Trypanosoma cruzi (T. cruzi) causes Chagas, which is a neglected tropical disease (NTD). WHO estimates that 6 to 7 million people are infected worldwide. Current treatment is done with benznidazole (BZN), which is very toxic and effective only in the acute phase of the disease. In this work, we designed, synthesized, and characterized thirteen new phenoxyhydrazine-thiazole compounds and applied molecular docking and in vitro methods to investigate cell cytotoxicity, trypanocide activity, nitric oxide (NO) production, cell death, and immunomodulation...
April 7, 2024: Experimental Parasitology