keyword
https://read.qxmd.com/read/37133932/a-double-blind-sham-controlled-trial-of-home-administered-rhythmic-10-hz-median-nerve-stimulation-for-the-reduction-of-tics-and-suppression-of-the-urge-to-tic-in-individuals-with-tourette-syndrome-and-chronic-tic-disorder
#21
RANDOMIZED CONTROLLED TRIAL
Barbara Morera Maiquez, Caitlin Smith, Katherine Dyke, Chia-Ping Chou, Belinda Kasbia, Ciara McCready, Hannah Wright, Jessica K Jackson, Isabel Farr, Erika Badinger, Georgina M Jackson, Stephen R Jackson
Tourette syndrome (TS) and chronic tic disorder (CTD) are neurological disorders of childhood onset characterized by the occurrence of tics; repetitive, purposeless, movements or vocalizations of short duration which can occur many times throughout a day. Currently, effective treatment for tic disorders is an area of considerable unmet clinical need. We aimed to evaluate the efficacy of a home-administered neuromodulation treatment for tics involving the delivery of rhythmic pulse trains of median nerve stimulation (MNS) delivered via a wearable 'watch-like' device worn at the wrist...
September 2023: Journal of Neuropsychology
https://read.qxmd.com/read/37108353/dna-demethylation-of-myogenic-genes-may-contribute-to-embryonic-leg-muscle-development-differences-between-wuzong-and-shitou-geese
#22
JOURNAL ARTICLE
Xumeng Zhang, Yong Li, Chenyu Zhu, Fada Li, Zhiyuan Liu, Xiujin Li, Xu Shen, Zhongping Wu, Mengsi Fu, Danning Xu, Yunbo Tian, Yunmao Huang
Skeletal muscle development from embryonic stages to hatching is critical for poultry muscle growth, during which DNA methylation plays a vital role. However, it is not yet clear how DNA methylation affects early embryonic muscle development between goose breeds of different body size. In this study, whole genome bisulfite sequencing (WGBS) was conducted on leg muscle tissue from Wuzong (WZE) and Shitou (STE) geese on embryonic day 15 (E15), E23, and post-hatch day 1. It was found that at E23, the embryonic leg muscle development of STE was more intense than that of WZE...
April 13, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36967382/tumor-targeted-superantigens-produce-curative-tumor-immunity-with-induction-of-memory-and-demonstrated-antigen-spreading
#23
JOURNAL ARTICLE
Meir Azulay, Michal Shahar, Eitan Shany, Eti Elbaz, Sveta Lifshits, Marie Törngren, Adam Friedmann, Robert Kramer, Gunnar Hedlund
BACKGROUND: Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy against many types of solid tumors. One major barrier to effective treatment is the lack of a durable long-term response. Tumor-targeted superantigen (TTS) therapy may overcome this barrier to enhance therapeutic efficacy. TTS proteins, such as the clinical-stage molecule naptumomab estafenatox (NAP), increase tumor recognition and killing by both coating tumor cells with bacterial-derived superantigens (SAgs) and selectively expanding T-cell lineages that can recognize them...
March 26, 2023: Journal of Translational Medicine
https://read.qxmd.com/read/36889364/novel-through-the-scope-suture-closure-of-colonic-endoscopic-mucosal-resection-defects
#24
JOURNAL ARTICLE
Danse Bi, Linda Y Zhang, Mohammad Alqaisieh, Apurva Shrigiriwar, Jad Farha, Tala Mahmoud, Karl Akiki, Antonio Almario Jose, Sardar M Shah-Khan, Stuart R Gordon, Jeffrey M Adler, Mark Radetic, Peter V Draganov, Yakira N David, Brianna Shinn, Zahraa Mohammed, Alexander Schlachterman, Sofia Yuen, Ahmad Al-Taee, Namn Yunseok, Roberto Trasolini, Michael Bejjani, Bachir Ghandour, Hemchand Ramberan, Andrew Canakis, Saowanee Ngamruengphong, Andrew C Storm, Shailendra Singh, Heiko Pohl, Juan Carlos Bucobo, Jonathan M Buscaglia, Lionel S D'Souza, Bashar Qumseya, Nikhil A Kumta, Anand Kumar, Gregory B Haber, Aihara Hiroyuki, Mandeep Sawhney, Raymond Kim, Tyler M Berzin, Mouen A Khashab
BACKGROUND AND AIMS: Large colon polyps removed by endoscopic mucosal resection (EMR) can be complicated by delayed bleeding. Prophylactic defect clip closure can reduce post-EMR bleeding. Larger defects can be challenging to close using through-the-scope clips (TTSCs) and proximal defects are difficult to reach using over-the-scope techniques. A novel, through-the-scope suture (TTSS) device allows direct closure of mucosal defects without scope withdrawal. We aim to evaluate the rate of delayed bleeding following the closure of large colon polyp EMR sites with TTSS...
March 6, 2023: Gastrointestinal Endoscopy
https://read.qxmd.com/read/36693419/endoscopic-management-of-gastrointestinal-wall-defects-fistula-closure-and-stent-fixation-using-through-the-scope-tack-and-suture-system
#25
JOURNAL ARTICLE
Arunkumar Krishnan, Sardar M Shah-Khan, Yousaf Hadi, Neel Patel, Shyam Thakkar, Shailendra Singh
BACKGROUND : Multiple devices are available for tissue approximation. A new through-the-scope suturing (TTSS) device has recently been introduced; however, data on its scope of use and clinical effectiveness are limited. We aimed to assess the clinical course and effectiveness of this TTSS device. METHODS : A retrospective review was performed for consecutive patients who underwent TTSS application. Primary outcomes were technical and clinical success, and secondary outcomes included adverse events and long-term clinical success...
March 13, 2023: Endoscopy
https://read.qxmd.com/read/36653803/surgical-and-perioperative-management-of-flail-chest-with-titanium-plates-a-french-cohort-series-from-a-thoracic-referral-center
#26
JOURNAL ARTICLE
Sarah Féray, Clarisse Blayau, Hicham Masmoudi, Samuel Haddad, Christophe Quesnel, Jalal Assouad, Muriel Fartoukh
BACKGROUND: The development of titanium claw plates has made rib osteosynthesis easy to achieve and led to a renewed interest for this surgery. We report the management of patients referred to the intensive care unit (ICU) of a referral center for surgical rib fracture fixation (SRFF) after chest trauma. METHODS: We performed a retrospective observational cohort study describing the patients' characteristics and analyzing the determinants of postoperative complications...
January 18, 2023: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/36649686/long-term-clinical-and-cost-effectiveness-of-a-therapist-supported-online-remote-behavioural-intervention-for-tics-in-children-and-adolescents-extended-12-and-18-month-follow-up-of-a-single-blind-randomised-controlled-trial
#27
JOURNAL ARTICLE
Chris Hollis, Charlotte L Hall, Kareem Khan, Rebecca Jones, Louise Marston, Marie Le Novere, Rachael Hunter, Per Andrén, Sophie D Bennett, Beverley J Brown, Liam R Chamberlain, E Bethan Davies, Amber Evans, Natalia Kouzoupi, Caitlin McKenzie, Charlotte Sanderson, Isobel Heyman, Joseph Kilgariff, Cristine Glazebrook, David Mataix-Cols, Eva Serlachius, Elizabeth Murray, Tara Murphy
BACKGROUND: Little is known about the long-term effectiveness of behavioural therapy for tics. We aimed to assess the long-term clinical and cost-effectiveness of online therapist-supported exposure and response prevention (ERP) therapy for tics 12 and 18 months after treatment initiation. METHODS: ORBIT (online remote behavioural intervention for tics) was a two-arm (1:1 ratio), superiority, single-blind, multicentre randomised controlled trial comparing online ERP for tics with online psychoeducation...
January 17, 2023: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://read.qxmd.com/read/36587853/appraisal-of-kenya-s-excisable-goods-management-system-using-interrupted-time-series-analysis-a-case-of-cigarettes-and-cigars-excise-tax-revenue
#28
JOURNAL ARTICLE
Boaz Munga, Adan Guyo Shibia, Eldah Onsomu
The government of Kenya introduced the Excisable Goods Management System (EGMS) in November 2013, which is a form of Track and Trace Systems (TTSs) for excisable goods, including cigarettes and cigars. This study appraised the EGMS with a focus on its impact on cigarette and cigars excise tax revenue and possibly control of related illicit trade in Kenya. Illicit trade in cigarettes and cigars pose significant health risks owing to increased access to tobacco products, besides contributing to loss of government revenues...
December 29, 2022: Preventive Medicine
https://read.qxmd.com/read/36551784/coupling-crispr-cas9-and-lambda-red-recombineering-system-for-genome-editing-of-salmonella-gallinarum-and-the-effect-of-ssau-knock-out-mutant-on-the-virulence-of-bacteria
#29
JOURNAL ARTICLE
Hamza Tahir, Abdul Basit, Hafsa Tariq, Zulquernain Haider, Asim Ullah, Zafar Hayat, Shafiq Ur Rehman
The poultry industry in developing countries still faces a significant threat from fowl typhoid, a disease caused by Salmonella Gallinarum that has been well contained in more economically developed countries. In addition to the virulence exhibited by large virulence plasmid (85 kb), Salmonella Pathogenicity Island 2 in S . Gallinarum plays a key role in mediating disease through its type III secretion systems (TTSS). The TTSS secrete effector protein across the Salmonella containing vacuoles and mediate the internalization of bacteria by modulating vesicular passage...
November 24, 2022: Biomedicines
https://read.qxmd.com/read/36532321/should-dentists-mandatorily-wear-ear-protection-device-to-prevent-occupational-noise-induced-hearing-loss-a-randomized-case-control-study
#30
JOURNAL ARTICLE
Kishan M Mohan, Aditi Chopra, Vasudeva Guddattu, Shruti Singh, Kumari Upasana
OBJECTIVES: Dentists are constantly exposed to high-frequency noise at their workplace that increases the risk of occupational noise-induced hearing loss (ONIHL). Even though dentists acknowledge about the noisy dental workplace, hearing protection devices or ear protection devices (EPD) are not commonly used by dentists. No study has yet provided any evidence on how effective EPDs can be in reducing the temporary threshold shift and damage to the outer, middle and inner ears. The aim of this article is to evaluate and compare the changes in the hearing acuity and temporary threshold shift (TTS) in dentists who wear EPDs when compared with those who do not use EPDs...
2022: Journal of International Society of Preventive & Community Dentistry
https://read.qxmd.com/read/36450576/workflow-for-identification-of-burkholderia-pseudomallei-clinical-isolates-in-myanmar
#31
JOURNAL ARTICLE
Nay Myo Aung, Khine Khine Su, Narisara Chantratita, Chanwit Tribuddharat
Burkholderia pseudomallei, the highly infectious causative organism of melioidosis, was first discovered in Myanmar in 1911. The identification of B. pseudomallei was elucidated in Myanmar because of its genetic relatedness among Burkholderia species. In this study, we identified 2 isolates of Burkholderia cenocepacia, 2 Acinetobacter baumannii complex, and 18 clinical isolates of B. pseudomallei by Vitek 2. These isolates were first screened with a latex agglutination test, which showed positive results in 20 of 22 isolates...
November 30, 2022: Japanese Journal of Infectious Diseases
https://read.qxmd.com/read/36424734/finite-element-analysis-and-transiliac-transsacral-screw-fixation-for-posterior-pelvic-ring-with-sacrum-dysplasia
#32
JOURNAL ARTICLE
Chao Wu, Baifang Zeng, Jiayan Deng, Binwei Qin, Danwei Shen, Xiangyu Wang, Haigang Hu, Li Huang, Xin Liu, Guigang Qiu
OBJECTIVE: Posterior pelvic ring sacroiliac screws are preferred by clinicians for their good biomechanical performance. However, there are few studies on mechanical analysis and intraoperative screw insertion of the dysplastic sacrum and sacroiliac screw. This study investigated the biomechanical performance of oblique sacroiliac screws (OSS) in S1 combined with transiliac-transsacral screws (TTSs) in S2 for pelvic fracture or sacroiliac dislocation with dysplastic sacrum and evaluated the safety of screw placement assisted by the navigation template...
November 24, 2022: Orthopaedic Surgery
https://read.qxmd.com/read/36415531/molecular-detection-of-metallo-beta-lactamase-and-alginate-in-multidrug-resistance-pseudomonas-aeruginosa-isolated-from-the-clinical-specimen
#33
JOURNAL ARTICLE
Govend Musa Qader, Khanzad Khudhur Jarjees, Rozhhalat Khudhur Jarjees
Pseudomonas aeruginosa pathogen is opportunistic. Several virulence factors and biofilms can cause its pathogenicity. Furthermore, infections triggered via multidrug-resistant P. aeruginosa among hospitalized patients are a public health concern. The primary antimicrobial agents in treating Gram-negative infection include Meropenem and Imipenem. Moreover, the spread of Carbapenem-resistant P. aeruginosa is a focal concern worldwide. The present research aims to determine the spread of Carbapenem-resistant P...
September 2022: Journal of Medicine and Life
https://read.qxmd.com/read/36323330/a-novel-through-the-scope-helix-tack-and-suture-device-for-mucosal-defect-closure-following-colorectal-endoscopic-submucosal-dissection-esd-a-multicenter-study
#34
JOURNAL ARTICLE
Jad Farha, Hemchand Ramberan, Hiroyuki Aihara, Linda Y Zhang, Amit Mehta, Camille Hage, Alexander Schlachterman, Anand Kumar, Brianna Shinn, Andrew Canakis, Raymond Eunho Kim, Lionel S D'Souza, Jonathan Buscaglia, Andrew C Storm, Jason Samarasena, Kenneth Chang, Shai Friedland, Peter V Dragonov, Bashar Qumseya, Salmaan Jawaid, Mohamed O Othman, Muhammad Khalid Hasan, Dennis Yang, Mouen A Khashab, Saowanee Ngamruengphong
BACKGROUND: Complete closure of large mucosal defects following colorectal ESD with through-the-scope clips (TTSC) is oftentimes not possible. We aimed to report an early experience of using a novel through-the-scope suturing system (TTSS) for closing large mucosal defects after colorectal ESD. METHODS: We performed a retrospective, multi-center cohort study of consecutive patients who underwent attempted prophylactic defect closure using TTSS after colorectal ESD...
November 2, 2022: Endoscopy
https://read.qxmd.com/read/36297391/development-of-capsaicin-containing-analgesic-silicone-based-transdermal-patches
#35
JOURNAL ARTICLE
Szabolcs László, István Z Bátai, Szilvia Berkó, Erzsébet Csányi, Ágnes Dombi, Gábor Pozsgai, Kata Bölcskei, Lajos Botz, Ödön Wagner, Erika Pintér
Transdermal therapeutic systems (TTSs) enable convenient dosing in drug therapy. Modified silicone-polymer-based patches are well-controlled and cost-effective matrix diffusion systems. In the present study, we investigated the substance release properties, skin penetration, and analgesic effect of this type of TTS loaded with low-dose capsaicin. Release properties were measured in Franz diffusion cell and continuous flow-through cell approaches. Capsaicin was detected with HPLC-UV and UV spectrophotometry...
October 18, 2022: Pharmaceuticals
https://read.qxmd.com/read/36146345/a-long-short-term-memory-based-approach-for-detecting-turns-and-generating-road-intersections-from-vehicle-trajectories
#36
JOURNAL ARTICLE
Zijian Wan, Lianying Li, Huafei Yu, Min Yang
Owing to the widespread use of GPS-enabled devices, sensing road information from vehicle trajectories is becoming an attractive method for road map construction and update. Although the detection of intersections is critical for generating road networks, it is still a challenging task. Traditional approaches detect intersections by identifying turning points based on the heading changes. As the intersections vary greatly in pattern and size, the appropriate threshold for heading change varies from area to area, which leads to the difficulty of accurate detection...
September 15, 2022: Sensors
https://read.qxmd.com/read/36034071/endoscopic-full-thickness-resection-with-through-the-scope-suture-closure-for-gastrointestinal-stromal-tumor
#37
JOURNAL ARTICLE
Linda Y Zhang, Bachir Ghandour, Michael Bejjani, Mouen A Khashab
Video 1Endoscopic full-thickness resection with through-the-scope suture closure for gastrointestinal stromal tumor.
August 2022: VideoGIE
https://read.qxmd.com/read/36015053/localization-of-epigenetic-markers-in-leishmania-chromatin
#38
JOURNAL ARTICLE
Jacquelyn R McDonald, Bryan C Jensen, Aakash Sur, Iris L K Wong, Stephen M Beverley, Peter J Myler
Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding genes into large polycistronic transcription units (PTUs), trypanosomatid parasites also employ a "histone code" to control these processes, but the details of this epigenetic code are poorly understood. Here, we present the results of experiments designed to elucidate the distribution of histone variants and PTMs over the chromatin landscape of Leishmania tarentolae ...
August 18, 2022: Pathogens
https://read.qxmd.com/read/35969401/therapist-supported-internet-delivered-exposure-and-response-prevention-for-children-and-adolescents-with-tourette-syndrome-a-randomized-clinical-trial
#39
RANDOMIZED CONTROLLED TRIAL
Per Andrén, Moa Holmsved, Helene Ringberg, Vera Wachtmeister, Kayoko Isomura, Kristina Aspvall, Fabian Lenhard, Charlotte L Hall, E Bethan Davies, Tara Murphy, Chris Hollis, Filipa Sampaio, Inna Feldman, Matteo Bottai, Eva Serlachius, Erik Andersson, Lorena Fernández de la Cruz, David Mataix-Cols
Importance: The availability of behavior therapy for individuals with Tourette syndrome (TS) and chronic tic disorder (CTD) is limited. Objective: To determine the efficacy and cost-effectiveness of internet-delivered exposure and response prevention (ERP) for children and adolescents with TS or CTD. Design, Setting, and Participants: This single-masked, parallel group, superiority randomized clinical trial with nationwide recruitment was conducted at a research clinic in Stockholm, Sweden...
August 1, 2022: JAMA Network Open
https://read.qxmd.com/read/35807692/-pseudomonas-cannabina-pv-alisalensis-virulence-factors-are-involved-in-resistance-to-plant-derived-antimicrobials-during-infection
#40
JOURNAL ARTICLE
Nanami Sakata, Takumi Haraguchi, Shunsuke Masuo, Takako Ishiga, Yasuhiro Ishiga
Bacteria are exposed to and tolerate diverse and potentially toxic compounds in the natural environment. While efflux transporters are generally thought to involve bacterial antibiotic resistance in vitro, their contributions to plant bacterial virulence have so far been poorly understood. Pseudomonas cannabina pv. alisalensis ( Pcal ) is a causal agent of bacterial blight of Brassicaceae. We here demonstrated that NU19, which is mutated in the resistance-nodulation-cell division (RND) transporter encoded gene, showed reduced virulence on cabbage compared to WT, indicating that the RND transporter contributes to Pcal virulence on cabbage...
June 30, 2022: Plants (Basel, Switzerland)
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